AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
FerritinsApoferritinsIronHemosiderinTransferrinAnemia, Iron-DeficiencyIron Metabolism DisordersIron-Regulatory ProteinsIron OverloadReceptors, TransferrinIron RadioisotopesDeferoxamineHemochromatosisSiderosisHemoglobinsAnemia, HypochromicIron Chelating AgentsFerrous CompoundsFerric CompoundsIron Regulatory Protein 1CeruloplasminErythrocyte IndicesFerrozineIron-Binding ProteinsPhlebotomyHorsesIron Regulatory Protein 2BloodlettingIron-Dextran ComplexLiverbeta-ThalassemiaHepcidinsHemosiderosisEncyclopedias as Topic
Ferritins
Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.
Apoferritins
The protein components of ferritins. Apoferritins are shell-like structures containing nanocavities and ferroxidase activities. Apoferritin shells are composed of 24 subunits, heteropolymers in vertebrates and homopolymers in bacteria. In vertebrates, there are two types of subunits, light chain and heavy chain. The heavy chain contains the ferroxidase activity.
Iron
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Hemosiderin
Transferrin
An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.
Anemia, Iron-Deficiency
Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.
Iron Metabolism Disorders
Disorders in the processing of iron in the body: its absorption, transport, storage, and utilization. (From Mosby's Medical, Nursing, & Allied Health Dictionary, 4th ed)
Iron-Regulatory Proteins
Proteins that regulate cellular and organismal iron homeostasis. They play an important biological role by maintaining iron levels that are adequate for metabolic need, but below the toxicity threshold.
Iron Overload
An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
Receptors, Transferrin
Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released.
Iron Radioisotopes
Unstable isotopes of iron that decay or disintegrate emitting radiation. Fe atoms with atomic weights 52, 53, 55, and 59-61 are radioactive iron isotopes.
Deferoxamine
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Hemochromatosis
A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed)
Siderosis
A form of pneumoconiosis resulting from inhalation of iron in the mining dust or welding fumes.
Hemoglobins
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
Anemia, Hypochromic
Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)
Iron Chelating Agents
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.
Ferrous Compounds
Inorganic or organic compounds that contain divalent iron.
Ferric Compounds
Inorganic or organic compounds containing trivalent iron.
Iron Regulatory Protein 1
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
Ceruloplasmin
Erythrocyte Indices
ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC).
Ferrozine
A ferroin compound that forms a stable magenta-colored solution with the ferrous ion. The complex has an absorption peak at 562 nm and is used as a reagent and indicator for iron.
Iron-Binding Proteins
Proteins that specifically bind to IRON.
Phlebotomy
The techniques used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders such as erythrocytosis, hemochromatosis, polycythemia vera, and porphyria cutanea tarda.
Horses
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
Iron Regulatory Protein 2
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its rate of degradation is increased in the presence of IRON.
Bloodletting
Puncture of a vein to draw blood for therapeutic purposes. Bloodletting therapy has been used in Talmudic and Indian medicine since the medieval time, and was still practiced widely in the 18th and 19th centuries. Its modern counterpart is PHLEBOTOMY.
Iron-Dextran Complex
A complex of ferric oxyhydroxide with dextrans of 5000 to 7000 daltons in a viscous solution containing 50 mg/ml of iron. It is supplied as a parenteral preparation and is used as a hematinic. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1292)
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
beta-Thalassemia
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Hepcidins
Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.
Hemosiderosis
Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

Coronary heart disease and iron status: meta-analyses of prospective studies. (1/3222)

BACKGROUND: Studies of iron status and coronary heart disease (CHD) have yielded conflicting results. In a systematic review ("meta-analysis"), we quantitatively assessed epidemiological associations reported in prospective studies. METHODS AND RESULTS: Studies were identified by computer-assisted searches of the published literature, scanning of relevant reference lists, hand searching of relevant journals, and discussions with relevant authors. The following was abstracted: size and type of cohort, mean age, mean duration of follow-up, assay methods, degree of adjustment for confounders, and relationship of CHD risk to the baseline assay results. Twelve studies were identified, involving a total of 7800 CHD cases, with several reporting on >1 marker of iron status. For serum ferritin, with 570 CHD cases in 5 studies, comparison of individuals with baseline values >/=200 versus <200 microg/L yielded a combined risk ratio of 1.0 (95% CI, 0.8 to 1.3). For transferrin saturation, with 6194 CHD cases in 5 studies, comparison of individuals in the top third with those in the bottom third of the baseline measurements yielded a combined risk ratio of 0.9 (95% CI, 0.7 to 1.1). Comparisons of individuals in top and bottom thirds of baseline measurements also yielded nonsignificant risk ratios in combined analyses of studies involving total iron-binding capacity (combined risk ratio, 1.0; 95% CI, 0.7 to 1.5), serum iron (0.8; 95% CI, 0.7 to 1.0), and total dietary iron (0.8; 95% CI, 0.7 to 1.1). CONCLUSIONS: Published prospective studies do not provide good evidence to support the existence of strong epidemiological associations between iron status and CHD.  (+info)

The identification of ferritin in the nucleus of K562 cells, and investigation of a possible role in the transcriptional regulation of adult beta-globin gene expression. (2/3222)

We studied the subcellular distribution of ferritin in K562 cells by immunofluorescence techniques and have made a reappraisal of a direct binding interaction between ferritin and the proximal promoter region of the human beta-globin gene, as previously mentioned in the literature. Confocal microscopy indicates that ferritin, the iron-storage protein, is present in the nucleus of K562 cells, in addition to its expected cytoplasmic localisation. The stain distribution suggests that it is not directly associated with the nuclear matrix. Using a gel mobility shift assay, a protein that cross-reacts with monoclonal ferritin antibodies competitively binds to a double-stranded oligonucleotide spanning the region situated 150 base pairs upstream from the beta-globin transcription start site. Despite this antibody cross-reactivity, the protein is unlike cytosolic ferritin as it appears to be highly sensitive to both temperature and freeze-thaw cycles, and UV-crosslinking experiments indicate that the molecular mass of the protein factor lies between 90 and 100 kDa. In conclusion, while the intranuclear location of ferritin is described in the present study, ferritin is not in direct contact with the beta-globin promoter region.  (+info)

Ferritin mutants of Escherichia coli are iron deficient and growth impaired, and fur mutants are iron deficient. (3/3222)

Escherichia coli contains at least two iron storage proteins, a ferritin (FtnA) and a bacterioferritin (Bfr). To investigate their specific functions, the corresponding genes (ftnA and bfr) were inactivated by replacing the chromosomal ftnA and bfr genes with disrupted derivatives containing antibiotic resistance cassettes in place of internal segments of the corresponding coding regions. Single mutants (ftnA::spc and bfr::kan) and a double mutant (ftnA::spc bfr::kan) were generated and confirmed by Western and Southern blot analyses. The iron contents of the parental strain (W3110) and the bfr mutant increased by 1.5- to 2-fold during the transition from logarithmic to stationary phase in iron-rich media, whereas the iron contents of the ftnA and ftnA bfr mutants remained unchanged. The ftnA and ftnA bfr mutants were growth impaired in iron-deficient media, but this was apparent only after the mutant and parental strains had been precultured in iron-rich media. Surprisingly, ferric iron uptake regulation (fur) mutants also had very low iron contents (2.5-fold less iron than Fur+ strains) despite constitutive expression of the iron acquisition systems. The iron deficiencies of the ftnA and fur mutants were confirmed by Mossbauer spectroscopy, which further showed that the low iron contents of ftnA mutants are due to a lack of magnetically ordered ferric iron clusters likely to correspond to FtnA iron cores. In combination with the fur mutation, ftnA and bfr mutations produced an enhanced sensitivity to hydroperoxides, presumably due to an increase in production of "reactive ferrous iron." It is concluded that FtnA acts as an iron store accommodating up to 50% of the cellular iron during postexponential growth in iron-rich media and providing a source of iron that partially compensates for iron deficiency during iron-restricted growth. In addition to repressing the iron acquisition systems, Fur appears to regulate the demand for iron, probably by controlling the expression of iron-containing proteins. The role of Bfr remains unclear.  (+info)

Ferroxidase activity of ferritin: effects of pH, buffer and Fe(II) and Fe(III) concentrations on Fe(II) autoxidation and ferroxidation. (4/3222)

It is widely accepted that iron deposition in the iron storage protein ferritin in vitro involves Fe(II) oxidation, and that ferritin facilitates this oxidation at a ferroxidase site on the protein. However, these views have recently been questioned, with the protein ferroxidase activity instead being attributed to autoxidation from the buffer alone. Ligand exchange between another protein with ferroxidase activity and ferritin has been proposed as an alternative mechanism for iron incorporation into ferritin. In the present work, a pH stat apparatus is used to eliminate the influence of buffers on iron(II) oxidation. Here we show that the recent experiments questioning the ferroxidase activity of ferritin were flawed by inadequate pH control, that buffers actually retard rather than facilitate iron(II) oxidation, and that horse spleen ferritin has ferroxidase activity when measured under proper experimental conditions. Furthermore, high pH (7.0), a high Fe(II) concentration and the presence of Fe(III) all favour Fe(II) autoxidation in the presence or absence of ferritin.  (+info)

Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): a strategy for vascular immunotargeting of drugs. (5/3222)

Conjugation of drugs with antibodies to surface endothelial antigens is a potential strategy for drug delivery to endothelium. We studied antibodies to platelet-endothelial adhesion molecule 1 (PECAM-1, a stably expressed endothelial antigen) as carriers for vascular immunotargeting. Although 125I-labeled anti-PECAM bound to endothelial cells in culture, the antibody was poorly internalized by the cells and accumulated poorly after intravenous administration in mice and rats. However, conjugation of biotinylated anti-PECAM (b-anti-PECAM) with streptavidin (SA) markedly stimulated uptake and internalization of anti-PECAM by endothelial cells and by cells expressing PECAM. In addition, conjugation with streptavidin markedly stimulated uptake of 125I-labeled b-anti-PECAM in perfused rat lungs and in the lungs of intact animals after either intravenous or intraarterial injection. The antioxidant enzyme catalase conjugated with b-anti-PECAM/SA bound to endothelial cells in culture, entered the cells, escaped intracellular degradation, and protected the cells against H2O2-induced injury. Anti-PECAM/SA/125I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H2O2-induced injury. Thus, modification of a poor carrier antibody with biotin and SA provides an approach for facilitation of antibody-mediated drug targeting. Anti-PECAM/SA is a promising candidate for vascular immunotargeting of bioactive drugs.  (+info)

Transcriptional regulation of the mouse ferritin H gene. Involvement of p300/CBP adaptor proteins in FER-1 enhancer activity. (6/3222)

We previously identified a major enhancer of the mouse ferritin H gene (FER-1) that is central to repression of the ferritin H gene by the adenovirus E1A oncogene (Tsuji, Y., Akebi, N., Lam, T. K., Nakabeppu, Y., Torti, S. V., and Torti, F. M. (1995) Mol. Cell. Biol. 15, 5152-5164). To dissect the molecular mechanism of transcriptional regulation of ferritin H, E1A mutants were tested for their ability to repress FER-1 enhancer activity using cotransfection with ferritin H-chloramphenicol acetyltransferase (CAT) reporter constructs. Here we report that p300/CBP transcriptional adaptor proteins are involved in the regulation of ferritin H transcription through the FER-1 enhancer element. Thus, E1A mutants that failed to bind p300/CBP lost the ability to repress FER-1, whereas mutants of E1A that abrogated its interaction with Rb, p107, or p130 were fully functional in transcriptional repression. Transfection with E1A did not affect endogenous p300/CBP levels, suggesting that repression of FER-1 by E1A is not due to repression of p300/CBP synthesis, but to E1A and p300/CBP interaction. In addition, we have demonstrated that transfection of a p300 expression plasmid significantly activated ferritin H-CAT containing the FER-1 enhancer, but had a marginal effect on ferritin H-CAT with FER-1 deleted. Furthermore, both wild-type p300 and a p300 mutant that failed to bind E1A but retained an adaptor function restored FER-1 enhancer activity repressed by E1A. Sodium butyrate, an inhibitor of histone deacetylase, mimicked p300/CBP function in activation of ferritin H-CAT and elevation of endogenous ferritin H mRNA, suggesting that the histone acetyltransferase activity of p300/CBP or its associated proteins may contribute to the activation of ferritin H transcription. Recruitment of these broadly active transcriptional adaptor proteins for ferritin H synthesis may represent an important mechanism by which changes in iron metabolism are coordinated with other cellular responses mediated by p300/CBP.  (+info)

Iron-deficient diet reduces atherosclerotic lesions in apoE-deficient mice. (7/3222)

BACKGROUND: Iron deposition is evident in human atherosclerotic lesions, suggesting that iron may play a role in the development of atherosclerosis. To test this idea, the correlation between the extent of iron deposition and the severity of atherosclerosis in apolipoprotein E (apoE)-deficient mice was investigated. Furthermore, the effect of a low-iron diet on the progression of atherosclerotic lesions in these animals was evaluated. METHODS AND RESULTS: Iron deposition in tissues of apoE-deficient mice was examined by Perls' staining method. The results clearly demonstrated that iron deposits are present in atherosclerotic lesions and tissue sections of heart and liver in an age-dependent manner. When the young mice received a low-iron diet for 3 months, the hematocrit, serum iron, hemoglobin, and cholesterol concentrations were not significantly altered compared with those of littermates placed on a chow diet. However, the serum ferritin level of animals in the iron-restricted group was 27% to 30% lower than that of the control group in either sex. Furthermore, the lipoproteins isolated from the iron-restricted group exhibited greater resistance to copper-induced oxidation. Histological examination revealed that atherosclerotic lesions developed in mice fed a low-iron diet were significantly smaller than those found in control littermates. Likewise, the iron deposition as well as tissue iron content was much less in aortic tissues of the iron-restricted animals. Circulating autoantibodies to oxidized LDL and immunostains for epitopes of malondialdehyde-modified LDL detected on lesions were also significantly lower in mice fed a low-iron diet. CONCLUSIONS: Iron deposition is closely associated with the progression of atherosclerosis in apoE-deficient mice. Restriction in dietary iron intake leads to significant inhibition of lesion formation in these animals. These results suggest that the beneficial effect of a low-iron diet may be mediated, at least in part, by the reduction of iron deposition as well as LDL oxidation in vascular lesions.  (+info)

Effect of iron-, iodine-, and beta-carotene-fortified biscuits on the micronutrient status of primary school children: a randomized controlled trial. (8/3222)

BACKGROUND: Deficiencies of iron, iodine, and vitamin A are prevalent worldwide and can affect the mental development and learning ability of schoolchildren. OBJECTIVE: The aim of this study was to determine the effect of micronutrient-fortified biscuits on the micronutrient status of primary school children. DESIGN: Micronutrient status was assessed in 115 children aged 6-11 y before and after consumption of biscuits (fortified with iron, iodine, and beta-carotene) for 43 wk over a 12-mo period and was compared with that in a control group (n = 113) who consumed nonfortified biscuits. Cognitive function, growth, and morbidity were assessed as secondary outcomes. RESULTS: There was a significant between-group treatment effect on serum retinol, serum ferritin, serum iron, transferrin saturation, and urinary iodine (P <0.0001) and in hemoglobin and hematocrit (P <0.05). The prevalence of low serum retinol concentrations (<0.70 micromol/L) decreased from 39.1% to 12.2%, of low serum ferritin concentrations (<20 microg/L) from 27.8% to 13.9%, of anemia (hemoglobin <120 g/L) from 29.6% to 15.6%, and of low urinary iodine concentrations (<100 microg/L) from 97.5% to 5.4%. There was a significant between-group treatment effect (P <0.05) in cognitive function with the digit span forward task (short-term memory). Fewer school days were missed in the intervention than in the control group because of respiratory- (P = 0.097) and diarrhea-related (P = 0.013) illnesses. The intervention had no effect on anthropometric status [corrected]. CONCLUSIONS: Fortified biscuits resulted in a significant improvement in the micronutrient status of primary school children from a poor rural community and also appeared to have a favorable effect on morbidity and cognitive function [corrected].  (+info)

Characterization and localization of human placental ferritin | Biochemical JournalCharacterization and localization of human placental ferritin | Biochemical Journal
Ferritin has been purified from normal full-term human placentae and its antigenic and molecular characteristics compared with adult liver ferritin. Placental ferritin is composed predominantly of a single subunit type, co-migrating with a liver ferritin standard on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. Comparison of dose-response curves in an immunoradiometric assay indicated some tissue-specific antigenicity for placental ferritin. This was supported by immunofluorescence studies on cryostat sections of human placentae by using antibodies to placental and spleen ferritin. Specific staining for placental ferritin was demonstrated within placental syncytiotrophoblast, particularly localized towards the microvillus plasma membrane. Ferritin has also been shown by electrophoretic and antigenic analysis to be present in protein fractions solubilized from isolated human syncytiotrophoblast microvillus plasma-membrane preparations, suggesting that ferritin may play an active ...
http://www.biochemj.org/content/182/3/763
Expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron during cellular...
BACKGROUND: The expression of the two types of ferritin subunits, the H-subunit and L-subunit, has been shown to be differentially regulated by cytokines. The primary aim of the present study was to quantitatively measure the expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron in patients with chronic T-helper cell type-1 immune stimulation. METHODS: The expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron was quantitatively evaluated by post-embedding immunolocalisation with immunogold transmission electron microscopy. RESULTS: The present study showed up-regulation of the H-subunit of ferritin in the bone marrow macrophage in patients with pronounced cellular immune activation (94.7 ± 37.3 counts/μm2; n = 31 vs 72.4 ± 34.0 counts/μm2; n = 13, p-value = 0.037). CONCLUSION: This supports a possible role for H-subunit rich ferritins in the hypoferraemia of chronic disease ...
https://repository.up.ac.za/handle/2263/16806
Ferritin | Clinical Diagnostics | Bio-RadFerritin | Clinical Diagnostics | Bio-Rad
Ferritins (MW: ~ 450 kD) are polymeric proteins composed of 2 subunits a heavy chain and a light chain polypeptide, that reversibly bind and store iron in liver, spleen and bone marrow. The ferritin molecule consists of 24 self-assembling polypeptide subunits composed of the heavy and light chains. Ferritin light chain is the main intracellular iron storage protein. The proportion of heavy and light chain composing the ferritin molecule varies from tissue to tissue. This variation accounts for the differences in the rate of iron uptake and release in different tissues or organs. Recombinant Human Ferritin Light Chain is produced in E.coli as a single non-glycosylated polypeptide having a molecular weight of 19 kDa. Clinically, the monitoring of serum ferritin levels aides in the diagnosis and management of iron metabolic disorders. Serum levels increase in hepatic diseases, various malignancies, inflammation and late stage hemochromatosis. Ferritin levels are also indicative of the ero
http://www.bio-rad.com/en-ca/product/ferritin
Ferritin and ferritin isoforms I : structure-function relationships synthesis degradation and secretion
Ferritin is the intracellular protein responsible for the sequestration, storage and release of iron. Ferritin can accumulate up to 4500 iron atoms as a ferrihydrite mineral in a protein shell and releases these iron atoms when there is an increase in the cells need for bioavailable iron. The ferritin protein shell consists of 24 protein subunits of two types, the H-subunit and the L-subunit. These ferritin subunits perform different functions in the mineralization process of iron. The ferritin protein shell can exist as various combinations of these two subunit types, giving rise to heteropolymers or isoferritins. Isoferritins are functionally distinct and characteristic populations of isoferritins are found depending on the type of cell, the proliferation status of the cell and the presence of disease. The synthesis of ferritin is regulated both transcriptionally and translationally. Translation of ferritin subunit mRNA is increased or decreased, depending on the labile iron pool and is ...
https://repository.up.ac.za/handle/2263/3837
Spectroscopic evidence for and characterization of a trinuclear ferroxidase center in bacterial ferritin from Desulfovibrio...Spectroscopic evidence for and characterization of a trinuclear ferroxidase center in bacterial ferritin from Desulfovibrio...
Ferritins are ubiquitous and can be found in practically all organisms that utilize Fe. They are composed of 24 subunits forming a hollow sphere with an inner cavity of ~80 A in diameter. The main function of ferritin is to oxidize the cytotoxic Fe(2+) ions and store the oxidized Fe in the inner cavity. It has been established that the initial step of rapid oxidation of Fe(2+) (ferroxidation) by H-type ferritins, found in vertebrates, occurs at a diiron binding center, termed the ferroxidase center. In bacterial ferritins, however, X-ray crystallographic evidence and amino acid sequence analysis revealed a trinuclear Fe binding center comprising a binuclear Fe binding center (sites A and B), homologous to the ferroxidase center of H-type ferritin, and an adjacent mononuclear Fe binding site (site C). In an effort to obtain further evidence supporting the presence of a trinuclear Fe binding center in bacterial ferritins and to gain information on the states of the iron bound to the trinuclear ...
http://docentes.fct.unl.pt/ict/publications/spectroscopic-evidence-and-characterization-trinuclear-ferroxidase-center-bacterial
Incorporation and release of inorganic phosphate in horse spleen ferritin | Biochemical JournalIncorporation and release of inorganic phosphate in horse spleen ferritin | Biochemical Journal
When ferritin is reconstituted from Fe and apoferritin in vitro in the presence of Pi, the product obtained differs both from native ferritin and from ferritin reconstituted in the absence of Pi. When the latter is incubated with Pi the product resembles native ferritin with respect both to the pattern of Pi incorporated per molecule or per Fe atom and to the ease of release of this Pi relative to Fe release. It is concluded that much of the Pi of native ferritin is adsorbed on surfaces of ferritin iron-core crystallites. The results also suggest that Pi is not present at the intracellular site of Fe incorporation into ferritin, but is added after Fe. ...
http://www.biochemj.org/content/171/2/313
Cytoprotective effects of ferritin on doxorubicin-induced breast cancer cell death. - hepatonCytoprotective effects of ferritin on doxorubicin-induced breast cancer cell death. - hepaton
Ferritin is a major iron storage protein and essential for iron homeostasis. It has a wide range of functions in the body including iron delivery, immunosuppression, angiogenesis, and cell proliferation. Ferritin is overexpressed in many cancer cells, but its precise role in cancer is unclear. In the present study, we examined the functional roles of ferritin in protecting the MCF-7 breast cancer cell line against treatment with the chemotherapeutic agent doxorubicin. The effects of ferritin (human liver ferritin) and doxorubicin on the human MCF-7 breast cancer cell line were evaluated using the cell viability assay. The impact of decreasing ferritin light chain (FTL) and ferritin heavy chain (FTH) expression on doxorubicin sensitivity was assessed using siRNA. Reactive oxygen species (ROS) was also measured using the fluorescence probe CM-H2DCFDA. The mechanism of modulated chemosensitivity was evaluated by western blot analysis. Ferritin treatment activated MCF-7 cell proliferation in a ...
http://hepaton.com/186/cytoprotective-effects-of-ferritin-on-doxorubicin-induced-breast-cancer-cell-death/
Iron-storage disease - definition of iron-storage disease by The Free DictionaryIron-storage disease - definition of iron-storage disease by The Free Dictionary
Define iron-storage disease. iron-storage disease synonyms, iron-storage disease pronunciation, iron-storage disease translation, English dictionary definition of iron-storage disease. Noun 1. iron-storage disease - pathology in which iron accumulates in the tissues; characterized by bronzed skin and enlarged liver and diabetes mellitus...
http://www.thefreedictionary.com/iron-storage+disease
Effect of 40-cm segment umbilical cord milking on hemoglobin and serum ferritin at 6 months of age in full-term infants of...Effect of 40-cm segment umbilical cord milking on hemoglobin and serum ferritin at 6 months of age in full-term infants of...
TY - JOUR. T1 - Effect of 40-cm segment umbilical cord milking on hemoglobin and serum ferritin at 6 months of age in full-term infants of anemic and non-anemic mothers. AU - Bora, R.. AU - Akhtar, S. S.. AU - Venkatasubramaniam, A.. AU - Wolfson, Julian. AU - Rao, Raghu. PY - 2015/10/1. Y1 - 2015/10/1. N2 - Objective: To assess the effect of early clamping and milking of a 40-cm umbilical cord LUCM (long umbilical cord and milking) on hemoglobin (Hb) and serum ferritin concentrations at 6 months of age and to evaluate whether the effect is different in infants of anemic and non-anemic mothers. Study design: Eligible term-infants of anemic (maternal Hb,11.0 g dl-1) and non-anemic mothers (Hb ≥11.0 g dl-1) were randomized to LUCM or control groups (N=100 each). In the LUCM group, the umbilical cord was clamped at 40-cm length and milked. The control group had the cord clamped at 5 cm and not milked. Neonatal morbidities until discharge and Hb and serum ferritin at 6 months of age were compared. ...
https://experts.umn.edu/en/publications/effect-of-40-cm-segment-umbilical-cord-milking-on-hemoglobin-and-
Translation of ferritin light and heavy subunit mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma...Translation of ferritin light and heavy subunit mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma...
Acute administration of iron to rats has been previously shown to induce liver ferritin synthesis by increasing the translation of inactive cytoplasmic ferritin mRNAs for both heavy (H) and light (L) subunits by mobilizing them onto polyribosomes. In this report rat hepatoma cells in culture are used to explore the relationship of this response to intracellular iron levels. After adding iron as ferric ammonium citrate to the medium, latent ferritin H- and L-mRNAs were extensively transferred to polyribosomes, accompanied by increased uptake of [35S]methionine into ferritin protein. Because total cellular levels of L- and H-mRNA were not significantly changed by exposure to iron, the increased ferritin mRNAs on polyribosomes most probably come from an inactive cytoplasmic pool, consistent with the inability of actinomycin-D and of cordycepin to inhibit iron-induced ferritin synthesis. When deferoxamine mesylate, an intracellular iron chelator, was added after the addition of iron to the medium, ferritin
https://www.semanticscholar.org/paper/Translation-of-ferritin-light-and-heavy-subunit-mR-Rogers-Munro/2ae6d4a66c3f898d98fa61c600b35e4e21e9beba
Ferritin - WikipediaFerritin - Wikipedia
Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms, including algae, bacteria, higher plants, and animals. In humans, it acts as a buffer against iron deficiency and iron overload. Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. Plasma ferritin is also an indirect marker of the total amount of iron stored in the body, hence serum ferritin is used as a diagnostic test for iron-deficiency anemia. Ferritin is a globular protein complex consisting of 24 protein subunits forming a nanocage with multiple metal-protein interactions. It is the primary intracellular iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non-toxic form. Ferritin that is not combined with iron is called apoferritin. Ferritin genes are highly conserved between species. All vertebrate ferritin ...
https://en.wikipedia.org/wiki/Ferritin
Effects of Cardiorespiratory Fitness on Serum Ferritin Concentration a by Tuan D. Le, Sejong Bae et al.Effects of Cardiorespiratory Fitness on Serum Ferritin Concentration a by Tuan D. Le, Sejong Bae et al.
Published in Review of Diabetic Studies, Volume 5, Issue 4, Winter 2008, pages 245-252. Le, T.D., Bae, S., Hsu, C.E., Singh, K.P., Blair, S.N., Shang, N. (2009) Effects of Cardiorespiratory Fitness on Serum Ferritin Concentration and Incidence of Type 2 Diabetes: Evidence from the Aerobics Center Longitudinal Study (ACLS). Review of Diabetic Studies; 5:245-52.. © Review of Diabetic Studies 2009, The Society for Bio medical Diabetes Research ...
https://scholarcommons.sc.edu/sph_epidemiology_biostatistics_facpub/516/
H and L ferritins in myocardium in iron overload<...
TY - JOUR. T1 - H and L ferritins in myocardium in iron overload. AU - Arbustini, Eloisa. AU - Grasso, Maurizia. AU - Rindi, Guido. AU - Arosio, Paolo. AU - Gavazzi, Antonello. AU - Diegoli, Marta. AU - Bramerio, Manuela. AU - Levi, Sonia. AU - Barosi, Giovanni. PY - 1991/11/1. Y1 - 1991/11/1. N2 - Ferritin is an iron-containing protein composed of 2 subunits (H and L) with largely different primary structures and immunochemical properties. 1 The normal L-subunit-rich, basic isoferritin is prevalent in the liver and spleen, whereas the H-subunit-rich, acidic isoferritin predominates in the heart, pancreas and kidneys.2 A variation in heart isoferritin was reported in iron-overloaded patients,2 and the absence of the more acidic isoferritin was hypothesized to be specific for hereditary hemochromatosis.3 These observations prompted us to perform immunohistochemical investigations on H and L ferritins in endomyocardial biopsy samples of patients with primary or secondary iron overload, using ...
https://moh-it.pure.elsevier.com/en/publications/h-and-l-ferritins-in-myocardium-in-iron-overload
Biosynthesis of 57 Fe-enriched and 34 S-enriched Phaseolus vulgaris ferritin after heterologous expression in E.coli |...
Iron is an essential element for the living organisms but free iron can be toxic. Iron metabolism disorders affect a large portion of human population. There exists a need for development of a reference technique to measure body iron stores. The ideal technique for determination of body iron stores would to measure ferritin concentration along with ferritin iron saturation. This study uses the principle of Isotope Dilution Mass Spectrometry (IDMS) to measure serum ferritin bound iron. IDMS requires the biosynthesis of a ferritin spike with isotopically enriched iron and sulphur. The aim of this project was to synthesize a ferritin spike for serum ferritin and ferritin bound iron quantification for development of a reference technique to determine body iron stores. This study involved the biosynthesis of a ferritin spike labelled with isotopic iron and sulphur ...
https://scholarbank.nus.edu.sg/handle/10635/36359
Zinc protoporphyrin/haem ratio and plasma ferritin in preterm infants | ADC Fetal & Neonatal EditionZinc protoporphyrin/haem ratio and plasma ferritin in preterm infants | ADC Fetal & Neonatal Edition
In adults, ZPP/H is inversely correlated with plasma ferritin,12,14 and inversely related to the amount of stainable iron in the marrow.13 We observed a fall in plasma ferritin in the first year of life, which agrees with the known changes in body iron stores in neonates.11,19 However, rather than seeing the expected increase in ZPP/H during this period, a decrease was seen. Indeed ZPP/H and ferritin were directly, not inversely, related. When the entire dataset was examined using multiple regression, with age included in the model, there was no relation between log (ZPP/H) and log (ferritin). However, there was an inverse relation between average ZPP/H residuals for each subject, from a multiregression model, and corresponding log (ferritin) residuals. This suggests that subjects with a higher than average plasma ferritin tend to have lower ZPP/H (the between subject correlation). However, the relation was relatively weak (r = −0.22). When a similar model was used that incorporated subject, ...
http://fn.bmj.com/content/87/1/F49
Joint effects of serum ferritin and body mass index on the risk of coronary artery disease: a case-control study | BMJ OpenJoint effects of serum ferritin and body mass index on the risk of coronary artery disease: a case-control study | BMJ Open
CAD is a multifactorial chronic disease that develops from the interplay of genetic, lifestyle, physiological and other factors; a well understanding of the interaction between these risk factors is important to identify the target groups for CAD. In our previous study,20 serum ferritin was found to be an independent risk factor of CAD, and several studies21 have reported that obesity could elevate serum ferritin levels. However, whether there is an interaction of BMI with serum ferritin levels and CAD risk, and the extent to which the interaction influences the CAD risk are still unknown, and no study has reported the biological interaction of serum ferritin and BMI with CAD risk so far. Thus, in the present study, we explored the possible biological interaction of serum ferritin levels and BMI with CAD risk, and found evidence of additive interaction. This finding provided further evidence that iron overload to the risk of CAD appeared to be most significant among persons with higher ...
http://bmjopen.bmj.com/content/3/11/e003695
Cadmium in the structure of Cubic Crystal Structure of Native Horse Spleen Ferritin (pdb 1ier)
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Cadmium atom in PDB 1ier: Cubic Crystal Structure of Native Horse Spleen Ferritin
http://cadmium.atomistry.com/pdb1ier.html
Your Ferritin might be too high if… (February 2018) | heartmountainchiropractic.comYour Ferritin might be too high if… (February 2018) | heartmountainchiropractic.com
Ferritin is a protein in the body that stores iron and releases it. A simple blood test can determine this value for you. When Ferritin builds up, iron overload is the result. Over time, these excesses build up in major organs and if it is not removed, these organs can become diseased. This can be a genetic trait, in which it is called Hemochromatosis. However, this is the case only about 10% of patients with high Ferritin. Elevated Ferritin is a lot more common for other reasons than you think and is to not be overlooked. Untreated hemochromatosis can be fatal. More often though, the iron overload presents in patients with obesity, chronic inflammation, daily alcohol consumption, heart disease, liver disease, renal failure, joint paint, metabolic syndrome or diabetes, or even cancer.. Dr. Paul Adams of division of Gastroenterology University of Western Ontario, Canada says it is important to remember that elevated ferritin does not equal iron overload and there are many patients with elevated ...
http://heartmountainchiropractic.com/ferritin-might-high-february-2018/
Plus itPlus it
Serum ferritin is a sensitive indicator of available iron stores (1), but in certain instances it cannot be used in diagnosis, e.g., in anemias of chronic disease, infections, inflammation, liver disease, and malignancies (2)(3)(4)(5)(6)(7). Iron stores may be normal or increased, though accompanied by increased serum ferritin, in anemias of chronic disorders, aplastic anemia, sideroblastic anemia, and chronic hemolytic anemia. Because ferritin is also a positive acute-phase reactant protein that is increased in inflammation (2), serum ferritin concentration is not a reliable index of available iron stores in individuals with chronic diseases. There is no information, however, on whether ferritin can be used as a marker of available iron stores in the anemia of copper deficiency.. Unlike iron-deficiency anemia, in which body iron stores are usually depleted as evidenced by diminished serum ferritin concentrations, anemia of copper deficiency (8)(9)(10) results from increased hepatic iron stores ...
http://clinchem.aaccjnls.org/content/43/8/1457
Mössbauer spectroscopic studies of the cores of human, limpet and bacterial ferritins - Murdoch Research RepositoryMössbauer spectroscopic studies of the cores of human, limpet and bacterial ferritins - Murdoch Research Repository
Ferritin cores from human spleen, limpet (Patella vulgata) haemolymph and bacterial (Pseudomonasaeruginosa) cells have been investigated using 57Fe Mössbauer spectroscopy. The Mössbauer spectra were recorded over a range of temperatures from 1.3 to 78 K. At 78 K, all the spectra are quadrupole-split doublets with similar quadrupole splittings and isomer shifts, characteristic of iron(III), while at sufficiently low temperatures the spectra of all the samples show well-resolved magnetic splitting. At intermediate temperatures, the spectra from the human ferritin exhibit typical superparamagnetic behaviour, while those from the bacterial ferritin show behaviour corresponding to a transition from a magnetically ordered to a paramagnetic state. The spectra from the limpet ferritin show a complex combination of the two effects. The results are discussed in terms of the magnetic behaviour of small particles. The data are consistent with magnetic ordering temperatures of about 3 and 30 K for the ...
http://researchrepository.murdoch.edu.au/id/eprint/20680/
Association Between Serum Ferritin, Hemoglobin, Iron Intake, and Diabetes in Adults in Jiangsu, China | Diabetes CareAssociation Between Serum Ferritin, Hemoglobin, Iron Intake, and Diabetes in Adults in Jiangsu, China | Diabetes Care
The power to study diabetes in men was low. This could be one of the reasons why the association between iron status and diabetes was only significant in women. Serum ferritin is the most commonly used marker of stored body iron (15). However, serum ferritin is positively and hemoglobin is negatively associated by inflammation and infection (16). We do not have information on C-reactive protein, which is often used as an indicator of inflammation or infection. The association between hemoglobin and serum ferritin may thus be confounded by these conditions. In our results, we found a high prevalence of anemia (18.3 and 31.5%, for men and women, respectively), but the percentage having serum ferritin ,15 μg/l was only ∼9%. The prevalence of iron deficiency anemia was thus low: 6.3% among women and 0.7% among men. Thalassemia is not a problem in this area, with a prevalence of 0.09% (17).. It is reported that the prevalence of the hepatitis B virus marker is 42.6% and hepatitis B surface antigen ...
http://care.diabetesjournals.org/content/29/8/1878.long
What Do Elevated Ferritin Levels in Blood Tests Mean? | Reference.comWhat Do Elevated Ferritin Levels in Blood Tests Mean? | Reference.com
Elevated ferritin levels in a blood test can mean an individual has hemochromatosis, an infection, Hodgkins disease leukemia, inflammatory conditions or a diet too high in iron, according to WebMD....
https://www.reference.com/world-view/elevated-ferritin-levels-blood-tests-mean-2f925d3211c94d40
Plus itPlus it
Ferritin was measured in sera obtained at diagnosis from 241 patients with neuroblastoma to determine (a) the incidence of elevated ferritin and (b) the relationship between ferritin level and outcome. Ferritin was infrequently elevated in sera from patients with Stages I and II disease but was abnormally elevated in 37 and 54% of those with Stages III and IV neuroblastoma, respectively. The mean and median levels for each stage were compared and were highest for Stages III and IV disease. Analysis of progression-free survival for children with Stages III and IV disease indicated that elevated ferritin was associated with a significantly poorer prognosis than was normal ferritin and that this correlation was independent of stage and age at diagnosis. Progression-free survival at 24 months of follow-up for patients with Stage III disease with normal ferritin was 76% and with elevated ferritin was 23%. For those with Stage IV disease, progression-free survival was 27 and 3% with normal and ...
http://cancerres.aacrjournals.org/content/45/6/2843
Serum ferritin as a clinical marker for renal cell carcinoma: influence of tumor volume<...
TY - JOUR. T1 - Serum ferritin as a clinical marker for renal cell carcinoma. T2 - influence of tumor volume. AU - Partin, Alan Wayne. AU - Criley, Stuart R.. AU - Steiner, Mitchell S.. AU - Hsieh, Kisseng. AU - Simons, Jonathan W.. AU - Lumadue, Jeanne. AU - Carter, H Ballentine. AU - Marshall, Fray F.. PY - 1995. Y1 - 1995. N2 - Objectives. At present, 35% to 50% of patients with clinically localized renal cell carcinoma (RCC) unpredictably have a recurrence after surgical therapy. Presently, no clinical serum marker exists to detect occult metastases and to allow measurement of response to therapy in RCC. Serum ferritin was previously reported to correlate with pathologic stage. We postulated that this increase in serum ferritin with increasing stage might reflect tumor volume, since higher stage tumors are often larger. Methods. Serum ferritin levels were measured preoperatively in 30 patients with radiologic evidence of RCC. Tumor volume and the largest tumor dimension were calculated from ...
https://jhu.pure.elsevier.com/en/publications/serum-ferritin-as-a-clinical-marker-for-renal-cell-carcinoma-infl-4
Pre-altitude serum ferritin levels and daily oral iron supplement dose mediate iron parameter and hemoglobin mass responses to...Pre-altitude serum ferritin levels and daily oral iron supplement dose mediate iron parameter and hemoglobin mass responses to...
Altitude exposure (mean ± s: 21 ± 3 days) increased Hbmass by 1.1% [-0.4, 2.6], 3.3% [1.7, 4.8], and 4.0% [2.0, 6.1] from pre-altitude levels in athletes who ingested nil, 105 mg and 210 mg respectively, of oral iron supplement daily. Serum ferritin levels decreased by -33.2% [-46.9, -15.9] and 13.8% [-32.2, 9.7] from pre-altitude levels in athletes who supplemented with nil and 105 mg of oral iron supplement daily, but increased by 36.8% [1.3, 84.8] in athletes supplemented with 210 mg of oral iron daily. Finally, athletes who ingested either 105 mg or 210 mg of oral iron supplement daily had a greater TII compared with non-supplemented athletes (0 versus 105 mg: effect size (d) = -1.88 [-2.56, -1.17]; 0 versus 210 mg: effect size (d) = -2.87 [-3.88, -1.66 ...
https://acuresearchbank.acu.edu.au/item/85v10/pre-altitude-serum-ferritin-levels-and-daily-oral-iron-supplement-dose-mediate-iron-parameter-and-hemoglobin-mass-responses-to-altitude-exposure
Distribution of ferritin and redox-active transition metals in normal and cataractous human lensesDistribution of ferritin and redox-active transition metals in normal and cataractous human lenses
Previous studies have shown that lenticular levels of Fe and Cu are elevated in age-related cataract. However, it is not known if these metals are present in a state that is permissive for redox reactions that may lead to the formation of free radicals. In addition, there is little data available concerning the concentration and lenticular distribution of ferritin, the major intracellular Fe-sequestering protein, in the lens. The aim of the present work was therefore to determine the distribution of ferritin and the redox-availability of Fe and Cu in healthy and cataractous lenses. Lens ferritin distribution was assessed by ELISA and immunohistochemistry. A modified ELISA detected ferritin in an insoluble lens protein fraction. Ferritin levels were not significantly different in the cortex vs nucleus of healthy lenses. In contrast, ferritin levels in the cataractous lens nuclei appeared to be 70 % lower compared to the cortex. This was at least partially due to the presence of ferritin within ...
http://liu.diva-portal.org/smash/record.jsf?pid=diva2:248478
Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations | Clinical...Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations | Clinical...
The utility of plasma or serum ferritin in screening for iron deficiency in relatively healthy patients is well established (2)(3)(4) and is further supported by our results in the medical student population. However, directed evaluation of the cause of anemia in ill patients, particularly those with inflammatory diseases, can be difficult because of the acute-phase reactant properties of ferritin. In such patients, the diagnostic sensitivity of ferritin for iron deficiency can be compromised, and either bone marrow biopsy or determination of the response to iron therapy is required to completely assess iron status. sTfR concentration increases with iron deficiency and other causes of increased erythropoiesis but is not affected by acute or chronic inflammatory illnesses (8)(9)(10)(11). Accordingly, sTfR has been suggested as a highly sensitive laboratory test for iron deficiency (12)(13)(21). However, just as acute or chronic illnesses may yield falsely negative results for ferritin, other ...
http://clinchem.aaccjnls.org/content/44/1/45.full
Ferritin Structure from Mycobacterium tuberculosis: Comparative Study with Homologues Identifies Extended C-Terminus Involved...Ferritin Structure from Mycobacterium tuberculosis: Comparative Study with Homologues Identifies Extended C-Terminus Involved...
Ferritins are recognized as key players in the iron storage and detoxification processes. Iron acquisition in the case of pathogenic bacteria has long been established as an important virulence mechanism. Here, we report a 3.0 Å crystal structure of a ferritin, annotated as Bacterioferritin B (BfrB), from Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis that continues to be one of the worlds deadliest diseases. Similar to the other members of ferritin family, the Mtb BfrB subunit exhibits the characteristic fold of a four-helical bundle that possesses the ferroxidase catalytic centre. We compare the structure of Mtb BfrB with representatives of the ferritin family belonging to the archaea, eubacteria and eukarya. Unlike most other ferritins, Mtb BfrB has an extended C-terminus. To dissect the role of this extended C-terminus, truncated Mtb BfrB was purified and biochemical studies implicate this region in ferroxidase activity and iron release in addition to providing stability to
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018570
The hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. - Leibniz...The hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. - Leibniz...
Iron sequestration by host iron-binding proteins is an important mechanism of resistance to microbial infections. Inside oral epithelial cells, iron is stored within ferritin, and is therefore not usually accessible to pathogenic microbes. We observed that the ferritin concentration within oral epithelial cells was directly related to their susceptibility to damage by the human pathogenic fungus, Candida albicans. Thus, we hypothesized that host ferritin is used as an iron source by this organism. We found that C. albicans was able to grow on agar at physiological pH with ferritin as the sole source of iron, while the bakers yeast Saccharomyces cerevisiae could not. A screen of C. albicans mutants lacking components of each of the three known iron acquisition systems revealed that only the reductive pathway is involved in iron utilization from ferritin by this fungus. Additionally, C. albicans hyphae, but not yeast cells, bound ferritin, and this binding was crucial for iron acquisition from ...
https://www.leibniz-hki.de/de/institut-publikationsdetails.html?publication=527
Translocation and Function of Nuclear Ferritin - Penn State
Iron is an essential component of life. However, iron is also a potent biological toxin. Thus the bioavailability of iron must be stringently regulated. At the cellular level, if there is too little iron, a cell will lack the ability to meet its metabolic and biosynthetic requirements. If there is too much iron the cell become vulnerable to oxidative stress. Iron requiring metabolic reactions are found in both nuclei and cytoplasm and molecules in both compartments are vulnerable to oxidative stress. Indeed, iron-binding sites have been reported on DNA and iron induced DNA damage is well established. In the cytoplasm, ferritin regulates iron bioavailability. Recently, we and two other groups have provided evidence that ferritin is present in the nuclei of some cells. By virtue of its ability to take up and release iron, ferritin may be uniquely suited to both deliver iron to the nucleus as well as provide protection from iron induced oxidative stress. Our preliminary data show that nuclear ...
https://pennstate.pure.elsevier.com/en/projects/translocation-and-function-of-nuclear-ferritin-2
Association of Elevated Serum Ferritin Levels and the Risk of Gestational Diabetes Mellitus in Pregnant Women | Diabetes CareAssociation of Elevated Serum Ferritin Levels and the Risk of Gestational Diabetes Mellitus in Pregnant Women | Diabetes Care
The study was conducted in the Osborn Family Health Center, Our Lady of Lourdes Hospital, in Camden, New Jersey. Data were collected as part of the Camden Study, a prospective cohort study of maternal nutrition and pregnancy outcome in young, generally healthy women residing in one of the poorest cities in the continental U.S. (23). The institutional review board at the University of Medicine and Dentistry of New Jersey-SOM approved the study protocol. Informed written consent was obtained from each participant after explanation of the nature and purpose of the study.. Study participants were enrolled between October 1996 and June 2003 for prenatal care. Less than 5% of the women screened for eligibility were excluded from participation because of serious nonobstetric problem (e.g., lupus, type 1 or 2 diabetes, seizure disorders, malignancies, acute or chronic liver disease, drug or alcohol abuse, and psychiatric problems). Eighty percent of the patients who were eligible agreed to participate ...
https://care.diabetesjournals.org/content/29/5/1077?ijkey=6982f4048c21c7d5baacf2e018e51f82c05902b0&keytype2=tf_ipsecsha
Cellular uptake of soluble and aggregated ferritin: distinction between pinocytosis and phagocytosis | Journal of Cell ScienceCellular uptake of soluble and aggregated ferritin: distinction between pinocytosis and phagocytosis | Journal of Cell Science
Cellular uptake of ferritin amounting to 0-5 mug/mg cell protein or more can be measured colorimetrically on the basis of ferritin-iron content. 131I-serum albumin, soluble ferritin and aggregated ferritin used in equimolar concentrations are taken up differently by Sarcoma SI80 cells in culture. The net uptakes in 2 h at 37 degrees C are 0-065, 4-3 and 24-7 mug/mg cell protein or 0-93, 8-0 and 45-7 mumol, respectively. Albumin uptake is not inhibited by a 26-fold molar ferritin excess but is significantly inhibited by a 43-fold excess. The transport mechanism of the ferritins differs from that of albumin in that it is significantly inhibitable by 2 times 10(−4) M monoiodoacetate. Soluble ferritin contains small aggregates which are removed by filtration through Millipore membranes of 0-05, 0-1 and 0-22 mum. When the 0-1-mum filtrate is re-examined, uptake is no longer inhibited by iodoacetate. Since it can be inferred from other work that albumin is taken up by pinocytosis and ferritin ...
http://jcs.biologists.org/content/19/1/141
Very High FERRITIN Level of 3080.0 - Colon Cancer and Rectal Cancer Forum - Cancer ForumsVery High FERRITIN Level of 3080.0 - Colon Cancer and Rectal Cancer Forum - Cancer Forums
I was wondering if this has happened to anyone else...My husband has had over the past 18 months, more than 20 units of blood due to Chemo induced ANAEMIA...He is on his last cycle of gemzar/carbo platin treatment.... This week his blood reading came back with extremely high ferritin level of 3080.0 and our haemologist has recommended DEFERIPRONE (FERRITROX 270) in tablet form. The reason for the tablet form is because hubby has an ideal conduit and a colostomy ...so infusion in the belly
https://www.cancerforums.net/threads/26546-Very-High-FERRITIN-Level-of-3080.0
The response of ferritin to LPS and acute phase of Pseudomonas infection | [email protected]
Plasma ferritin is an important extracellular iron storage molecule, whose concentration increases drastically in cancer and infection. During infection, the pathogen usurps host iron for its survival and pathogenicity; hence, maintenance of the plasma ferritin level during infection is a crucial host defence mechanism. In this study, the horseshoe crab plasma ferritin complex was purified, characterized, and its involvement in innate immune defence was investigated. The plasma ferritin appears as a 21-kDa subunit on SDS-PAGE. Full-length ferritin-H cDNAs (CrFer-H1 and CrFer-H2) were cloned. Analysis of the 5′ UTR indicates the existence of a functional iron-response element, suggesting that both the CrFer-H genes may be post-transcriptionally regulated. Northern analysis shows that the CrFer-H is ubiquitously expressed. Within 3 h of lipopolysaccharide challenge, the gene is up-regulated by > 12-fold. In contrast, iron-loading did not result in any significant change. When challenged with ...
https://scholarbank.nus.edu.sg/handle/10635/101995
What are some causes of high ferritin levels? | Reference.comWhat are some causes of high ferritin levels? | Reference.com
Potential causes of high ferritin levels include liver disease, hyperthyroidism, rheumatoid arthritis and other inflammatory conditions, some forms of cancer, diabetes, multiple blood transfusions,...
https://www.reference.com/health/causes-high-ferritin-levels-f6e20028514ac1e3
High ferritin levels and post shoulder tendon operation pain/Exhausted? | Yahoo AnswersHigh ferritin levels and post shoulder tendon operation pain/Exhausted? | Yahoo Answers
I have high ferritin levels (over 800) but its not haemochromotosis. I recently had a bad fall (torn shoulder tendon) and had to get my shoulder operated on. I was prescribed strong pain killers (palexia). its called tapentadol. Ive stopped taking them as I worry theyre making me worse- but the pain persists. I am always so exhausted. I lie in bed all day. My joints hurt everywhere. My kids say ive become moody and irritable. im not sure what to do- my GP is struggling to assist. People tell me to go to emergency room but im not sure. Thank
https://answers.yahoo.com/question/index?qid=20210118113253AAY5ms9
Got fatigue? Increase your ferritin!Got fatigue? Increase your ferritin!
Ferritin levels are important for everyone-whether youre male or female, an avid exerciser or a couch potato. If your ferritin levels are too low, you may feel fatigued and run down, which can be a problem for anyone, no matter their level of physical activity. To find out exactly what your ferritin levels are, sign up for an InsideTracker plan. If your levels are out-of-range, InsideTracker will give you suggestions for diet, exercise, supplement and lifestyle changes to help you optimize them.
http://blog.insidetracker.com/got-fatigue-increase-your-ferritin
Homeostatic Mechanisms for Iron Storage Revealed by Genetic Manipulations and Live Imaging of Drosophila Ferritin | GeneticsHomeostatic Mechanisms for Iron Storage Revealed by Genetic Manipulations and Live Imaging of Drosophila Ferritin | Genetics
Several novel findings on Drosophila ferritin are described in this work. We show that the absence of either Fer1HCH or Fer2LCH results in embryonic lethality and that modified Fer1HCH subunits (mutant in the ferroxidase center or GFP tagged) cannot substitute for lack of Fer1HCH. However, if the same modified subunits are expressed in the presence of wild-type subunits, they can be integrated into ferritin holomers without inducing dominant-negative effects. Analysis of heterozygous loss-of-function ferritin fly mutants or flies overexpressing ferritin subunits revealed that a constant ratio of Fer1HCH and Fer2LCH is maintained, independent of their internal transcriptional expression levels. The structural cooperation of the two subunits that is secured via disulfide bonds (Hamburger et al. 2005) likely explains these observations. A post-transcriptional mechanism, possibly involving the degradation of subunits that are present in excess, ensures the presence of equal amounts of the two ...
http://www.genetics.org/content/177/1/89.full
SearchSearch
Previous studies have supported the theory that there is a positive association between ferritin and carotid atherosclerosis in Western people. Diet plays an important role in determining serum ferritin concentration. Asian dietary patterns are different from Western dietary patterns, implying that there may be a difference in the association of ferritin with carotid atherosclerosis between Asian and Western people. However, few studies focus on the association between ferritin and carotid atherosclerosis among Asians. The aim of this study was to investigate how serum ferritin levels are associated with carotid atherosclerosis in an Asian adult population. A cross-sectional assessment was performed in 8302 adults in Tianjin, China. Carotid intima-media thickness (IMT) and plaques were assessed using ultrasonography, and serum ferritin was measured using the protein chip-chemiluminescence method. Multiple logistic regression analysis was used to examine the association between quartiles of serum ...
https://www.cambridge.org/core/search?filters%5BauthorTerms%5D=FEI-FEI%20ZHANG&eventCode=SE-AU
Tissue ferritin concentration in carcinoma of the breastTissue ferritin concentration in carcinoma of the breast
Ferritin concentration was measured in cytosol extracts of 44 mammary carcinomas and 14 benign breast tissues. A six-fold difference was observed (mean, 364.6 +/- 223.3 ng/mcp in malignant tissue versus mean, 60.2 +/- 42.1 ng/mcp in benign tissue P less than 0.001). Thirty-five malignant tissue spec …
https://pubmed.ncbi.nlm.nih.gov/7139533/?dopt=Abstract
The response of intracellular and surface ferritin after T-cell stimulation in vitro | Clinical Science | Portland PressThe response of intracellular and surface ferritin after T-cell stimulation in vitro | Clinical Science | Portland Press
1. Measurements of T-lymphocyte surface ferritin using flow cytometry show that phytohaemagglutinin (PHA) stimulation causes a marked increase in the number of cells bearing spleen-type (S) and heart-type (H) ferritin on their membrane, whereas no such change occurs in non-stimulated cells. This coincides with increases in interleukin-2 receptors, transferrin receptors and HLA-DR antigen.. 2. There is an increase in the intracellular concentration of both S- and H-ferritin in lymphocytes after PHA stimulation: H-ferritin increases five- to seven-fold, but S-ferritin only two- to three-fold. The maximum H/S ratio is about 15/1. However, these increases also occur in cells cultured in the absence of PHA.. 3. Small amounts of both S- and H-ferritin are released into the medium, especially from stimulated cells, but the H/S ratios are lower than intracellular ratios.. 4. The present findings suggest that lymphocyte stimulation followed by ferritin synthesis is accompanied by an increase in the ...
https://portlandpress.com/clinsci/article-abstract/73/6/605/74277/The-response-of-intracellular-and-surface-ferritin?redirectedFrom=fulltext
Relationship of Body Iron Stores to Levels of Serum Ferritin, Serum Iron, Unsaturated Iron Binding Capacity and Transferrin...Relationship of Body Iron Stores to Levels of Serum Ferritin, Serum Iron, Unsaturated Iron Binding Capacity and Transferrin...
None of the methods for assessing total body iron burden in patients with hemochromatosis is satisfactory. Although it is commonly believed that a relationship exists between serum ferritin levels and
https://www.karger.com/Article/Abstract/57632
View of JADENU® SUBSTITUTING EXJADE® IN IRON OVERLOADED Β- THALASSEMIA MAJOR (BTM) PATIENTS: A PRELIMINARY REPORT OF THE...View of JADENU® SUBSTITUTING EXJADE® IN IRON OVERLOADED Β- THALASSEMIA MAJOR (BTM) PATIENTS: A PRELIMINARY REPORT OF THE...
Results: Apart from some minor gastrointestinal complaints reported in 3 BMT patients that did not require discontinuation of therapy, other side effects were not registered during the treatment. Subjectively, patients reported an improvement in the palatability of Jadenu® compared to Exjade® therapy in 8 out of 12 BMT patients. A non-significant decrease in LIC measured by Ferriscan® and serum ferritin levels was observed after one year of treatment with Jadenu®. A significant positive correlation was found between serum ferritin level and LIC measured by the FerriScan® method. LIC and serum ferritin level correlated significantly with ALT level (r = 0.31 and 0.45 respectively, p , 0.05). No significant correlation was detected between LIC and other biochemical or hormonal parameters.. Conclusion: Our study shows that short-term treatment with Jadenu® is safe but is associated with a non-significant decrease in LIC and serum ferritin levels. Therefore, there is an urgent need for ...
https://mjhid.org/index.php/mjhid/article/view/2018.064/3533
Serum Ferritin - Direct discounted blood work and lab testing - no doctor visit requiredSerum Ferritin - Direct discounted blood work and lab testing - no doctor visit required
Ferritin is a protein that transports iron in your bodys tissues. Research has shown that ferritin is a very reliable indicator of the status of your bodys iron stores. People who have very low or very high ferritin levels may have conditions that produce fatigue as a symptom.
https://yourlabwork.com/product/serum-ferritin-rtl/
Goat Anti Human Ferritin Antibody - Serum | Bio-RadGoat Anti Human Ferritin Antibody - Serum | Bio-Rad
Goat anti human ferritin antibody recognizes Human Ferritin, a large globular protein found in the liver, intestines and spleen that funct
https://www.bio-rad-antibodies.com/human-ferritin-antibody-obt1638.html
Ferritin for the clinicianFerritin for the clinician
Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a wide range of physiologic and pathologic processes. In clinical medicine, ferritin is predominantly utilized as a serum marker of total body iron stores. In cases of iron deficiency and overload, serum ferr …
https://pubmed.ncbi.nlm.nih.gov/18835072/?dopt=Abstract
High Serum Ferritin Concentrations in Polycystic Ovary Syndrome Is Not Related to Insulin Resistance - Iranian Journal of...High Serum Ferritin Concentrations in Polycystic Ovary Syndrome Is Not Related to Insulin Resistance - Iranian Journal of...
Iranian Journal of Diabetes and Obesity is scientific quarterly journal published by Shahid Sadoughi University of Medical Sciences
http://ijdo.ssu.ac.ir/browse.php?a_id=53&sid=1&slc_lang=en
FTH1 - WikipediaFTH1 - Wikipedia
Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene. This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. FTH1 has been shown to interact with Ferritin light chain. Ferritin GRCh38: Ensembl release 89: ENSG00000167996 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024661 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Hentze MW, Keim S, ...
https://en.wikipedia.org/wiki/FTH1
Sequence analysis of dolphin ferritin H and L subunits and possible iron-dependent translational control of dolphin ferritin...Sequence analysis of dolphin ferritin H and L subunits and possible iron-dependent translational control of dolphin ferritin...
Although a partial ferritin subunit sequence of the seal Phoca vitulina (AF246195, unpublished data) has been determined, the entire coding sequences of ferritin subunits in marine mammals were previously unknown. The present study shows the ferritin coding sequences coding for the H and L subunits of six different dolphin species (P. crassidens, L. obliquidens, G. griseus, G. macrorhyncus, T. truncatus, and D. leucas). The predicted secondary structures using the GENETYX-MAC computer program (Robson method) of dolphin ferritin H and L subunits show A, B, C, D, and short E-helices and the L loop connecting B and C helices (data not shown) as in other mammalian species [1-3, 18]. Sequence comparisons between dolphin ferritin and that of other mammalian species strongly suggest similar functions for the H subunit unique ferroxidase [2, 3, 18], the L subunit salt bridge [2, 8, 23] and iron nucleation site [2, 8], subunit dimer formation [8, 18], and the iron channel [8, 18]. A putative ...
https://actavetscand.biomedcentral.com/articles/10.1186/1751-0147-50-42
Serum ferritin, erythrocyte protoporphyrin and hemoglobin are valid indicators of iron status of school children in a malaria...
TY - JOUR. T1 - Serum ferritin, erythrocyte protoporphyrin and hemoglobin are valid indicators of iron status of school children in a malaria-holoendemic population. AU - Stoltzfus, Rebecca J.. AU - Chwaya, Hababu M.. AU - Albonico, Marco. AU - Schulze, Kerry J.. AU - Savioli, Lorenzo. AU - Tielsch, James M.. N1 - Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 1997/2. Y1 - 1997/2. N2 - In many African populations, the prevalences of both iron deficiency and malarial infection exceed 50%. The control of iron deficiency anemia is of urgent public health importance, but assessment of iron status in these contexts has been controversial because of the effects of malarial disease on common iron status indicators. We assessed iron status in 3605 school children in Zanzibar by measuring hemoglobin, erythrocyte protoporphyrin (EP) and serum ferritin concentrations. Malaria parasitemia was quantified by counting against leukocytes. Iron deficiency was highly prevalent: 62.4% of ...
https://jhu.pure.elsevier.com/en/publications/serum-ferritin-erythrocyte-protoporphyrin-and-hemoglobin-are-vali-3
Analysis of ferritins in lymphoblastoid cell lines and in the lens of subjects with hereditary hyperferritinemia-cataract...
Hereditary hyperferritinemia-cataract syndrome (HHCS) is an autosomal and dominant disease caused by heterogeneous mutations in the iron responsive element (IRE) of the 5 untranslated flanking region of ferritin L-chain mRNA, which reduce the binding to the trans iron regulatory proteins and make L-chain synthesis constitutively upregulated. In the several families identified so far, the serum and tissue L-ferritin levels are fivefold to 20- fold higher than in nonaffected control subjects, iron metabolism is apparently normal, and the only relevant clinical symptom is early onset, bilateral cataract. Some pathogenetic aspects of HHCS remain obscure, with particular reference to the isoferritins produced by HHCS cells, as well as the mechanism of cataract formation. We analyzed lymphoblastoid cell lines obtained from two nonaffected control subjects and from HHCS patients carrying the substitution A40G (Paris-1), G41C (Verona-1), and the deletion of the residues 10-38 (Verona-2) in the IRE ...
https://iris.univr.it/handle/11562/2357
Mouse Ferritin light chain 1, Ftl1 ELISA KITMouse Ferritin light chain 1, Ftl1 ELISA KIT
Mouse Ferritin light chain 1, Ftl1 ELISA KIT allows for the in vitro quantitative determination of Mouse Ftl1 concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.
https://www.lifescience-market.com/mouse-elisa-kit-c-65_71/mouse-ferritin-light-chain-1-ftl1-elisa-kit-p-39693.html
Identification of ferrous-ferric Fe3O4 nanoparticles in recombinant human ferritin cages. - Semantic ScholarIdentification of ferrous-ferric Fe3O4 nanoparticles in recombinant human ferritin cages. - Semantic Scholar
Recombinant ferritin is an excellent template for the synthesis of magnetic nanoparticles. This paper describes carefully performed experiments both to identify ironoxides within nanoparticles and to measure the number of iron atoms in the cores of recombinant human H-chain ferritin (HFn), based on spectroscopy techniques. Using electron energy-loss spectroscopy (EELS) analysis, magnetite (Fe3O4) has been unequivocally identified as the ironoxide formed within HFn cores under special preparation conditions. Atom counting analysis by EELS and high-angle annular dark-field imaging further allowed the correlation of the particle sizes to the real Fe atom numbers in a quantitative manner. These results help clarify some structural confusion between magnetite and maghemite (γ-Fe2O3), and also provide standard data for the number of Fe atoms within Fe3O4 particles of a given size, whose use is not limited to cases of magnetite synthesized in the cores of recombinant human ferritin.
https://www.semanticscholar.org/paper/Identification-of-ferrous-ferric-Fe3O4-nanoparticl-Walls-Cao/a43d86bbac2e9a24e42f20e5f6a7303f037e2350
Changed iron metabolism and iron toxicity in scrapie-infected neuroblastoma cellsChanged iron metabolism and iron toxicity in scrapie-infected neuroblastoma cells
Reactions and interactions of iron and oxygen can be both beneficial and detrimental to cells and tissues. Iron is mainly found in our blood where it functions as a mediator in the transport of oxygen to the cells and is further vital for the cellular respiration reducing the oxygen to water. The flexible redox state of iron makes it ideal to contribute in single electron transfers, but may also catalyze reactions with oxygen resulting in cell damaging reactive oxygen species (ROS). Normally the cells are protected against iron toxicity by controlling iron uptake and storage. When the intracellular demand for iron increases; the iron uptake is promoted by increasing the expression of transferrin receptor (TfR) and by decreasing the expression of the iron storage protein ferritin. Ferritin has a central role in the cellular iron detoxification by keeping it in a non reactive but still bioavailable form. However, in neurodegenerative diseases like in Alzheimers and Parkinsons disease the iron ...
http://su.diva-portal.org/smash/record.jsf?pid=diva2:196745
Serum iron and ferritin levels in alopecia areataSerum iron and ferritin levels in alopecia areata
Background: Alopecia Areate (AA) is a recurrent non-scarring patchy hair loss of autoimmune origin in a genetically susceptible individual although environmental factors may be contributory. The aim of this study is to evaluate serum iron and ferritin levels in patients with AA. Methods: Fifty patients of AA and 50 age and sex matched control subjects without any hair loss were studied. Results: No significant difference was found in mean hemoglobin, ferritin, and iron levels in two groups. Serum iron ferritin and hemoglobin levels did not show any significant variations with respect to the extent or duration of the disease, family history, history of atopy, and nail involvement. Conclusion: In our study, the levels of serum iron and ferritin showed no significant changes in AA patients and seems not to play a role in the etiology of AA.
http://iranjd.ir/article_98153.html
Genetic Determinants for Body Iron Store and Type 2 Diabetes Risk in US Men and WomenGenetic Determinants for Body Iron Store and Type 2 Diabetes Risk in US Men and Women
Background: High body iron store has been associated with an increased risk of type 2 diabetes (T2D); it remains unknown whether the genetic variants related to body iron status affect T2D risk. We aimed at comprehensively investigating the associations between the genetic variants related to body iron status and the T2D risk. Methodology/Principal Findings Six common SNPs related to body iron status from recent genome-wide association (GWA) studies were determined in the Nurses Health Study (NHS; 1,467 diabetic cases and 1,754 controls) and the Health Professionals Follow-up Study (HPFS; 1,124, diabetic cases and 1,298 controls). Plasma levels of ferritin, soluble transferrin receptor (sTfR), and transferrin were measured in NHS. Significant associations were observed for loci in TPMRSS6 with sTfR (P = 3.47×10−6), TF with transferrin (P = 0.0002 to 1.72×10−10); and HFE with ferritin (P = 0.017 to 1.6×10−8), sTfR (P = 0.007 to 7.9×10−6), and transferrin (P = 0.006 to 0.0007). The ...
https://dash.harvard.edu/handle/1/10054141
Change in Serum Iron as a Measure of Bioavailability of Dietary Iron by Mary Beth WrightChange in Serum Iron as a Measure of Bioavailability of Dietary Iron by Mary Beth Wright
Methods currently used to determine iron bioavailability have disadvantages for both the subjects and researchers involved. One safe and simple method that needs further evaluation, the serum iron absorption method, involves an initial blood drawing, dosage s of iron, and blood drawings taken at intervals thereafter. Generally, the rise in serum iron or area under the curve is used to determine iron uptake. Two experiments were conducted using the serum iron absorption method in an effort to improve the utility of this method for the measurement of iron bioavailability. With this effort in mind, an equation adjusting for dose of iron (0.5-8 mg) and blood volume was used to estimate serum iron absorption and allow for adequate comparisons of other iron absorption data obtained with this method and others. One very significant result was that low serum ferritin was found to be a predictor of high serum estimated iron absorption (SEIA). Similarly, low serum ferritin levels were also highly correlated to
https://digitalcommons.usu.edu/etd/5351/
A population-based study of the clinical expression of the hemochromatosis gene - UQ eSpace
Results: Sixteen of the subjects (0.5 percent) were homozygous for the C282Y mutation, and 424 (14.1 percent) were heterozygous. The serum transferrin saturation was 45 percent or higher in 15 of the 16 who were homozygous; in 1 subject it was 43 percent. Four of the homozygous subjects had previously been given a diagnosis of hemochromatosis, and 12 had not. Seven of these 12 patients had elevated serum ferritin levels in 1994; 6 of the 7 had further increases in 1998, and 1 had a decrease, although the value remained elevated. The serum ferritin levels in the four other homozygous patients remained in the normal range. Eleven of the 16 homozygous subjects underwent liver biopsy; 3 had hepatic fibrosis, and 1, who had a history of excessive alcohol consumption, had cirrhosis and mild microvesicular steatosis. Eight of the 16 homozygous subjects had clinical findings that were consistent with the presence of hereditary hemochromatosis, such as hepatomegaly, skin pigmentation, and arthritis ...
https://espace.library.uq.edu.au/view/UQ:142783
SOLUBLE TRANSFERRIN RECEPTOR (STFR), SERUM in Bangalore @₹1500 Only | 1 Tests | Dr Lal PathLabsSOLUBLE TRANSFERRIN RECEPTOR (STFR), SERUM in Bangalore @₹1500 Only | 1 Tests | Dr Lal PathLabs
Dr Lal PathLabs SOLUBLE TRANSFERRIN RECEPTOR (STFR), SERUM in Bangalore is health checkup package includes 1 Tests. ₹100 Cashback and Free Doctor Consultation, Home sample collection and Online reports available. SOLUBLE TRANSFERRIN RECEPTOR (STFR), SERUM in Bangalore covers 1 parameters- SOLUBLE TRANSFERRIN RECEPTOR (STFR), SERUM in Bangalore
https://www.hellodox.com/medical-tests/bangalore/soluble-transferrin-receptor-stfr-serum-3826
Do oligodendrocytes mediate iron regulation in the human brain?<...
TY - JOUR. T1 - Do oligodendrocytes mediate iron regulation in the human brain?. AU - Gerber, Megan R.. AU - Connor, James R.. PY - 1989/7. Y1 - 1989/7. N2 - We used immunohistochemical studies to demonstrate that transferrin (the iron mobilization protein) and ferritin (the iron storage protein) are specifically localized in oligodendrocytes in gray and white matter of the human central nervous system. In addition, iron is also localized predominantly in oligodendrocytes. Oligodendrocytes have been well established as the cells responsible for myelin production in the central nervous system. The results of this study suggest that oligodendrocytes (or a subpopulation of oligodendrocytes) might have the additional function of mediating iron mobilization and storage in the central nervous system.. AB - We used immunohistochemical studies to demonstrate that transferrin (the iron mobilization protein) and ferritin (the iron storage protein) are specifically localized in oligodendrocytes in gray and ...
https://pennstate.pure.elsevier.com/en/publications/do-oligodendrocytes-mediate-iron-regulation-in-the-human-brain
Correlation of serum ferritin levels with liver function tests and anthropometric measurements in transfusion dependent beta...Correlation of serum ferritin levels with liver function tests and anthropometric measurements in transfusion dependent beta...
Read on Correlation of Serum Ferritin Levels with Liver Function Tests and Anthropometric Measurements in Transfusion Dependent Beta-Thalassemia Major Children: A Cross Sectional Study.
https://www.pediatriconcall.com/pediatric-journal/view/fulltext-articles/1236/j/0/0/656/0
FDA Grants Diazyme 510(k) Clearance to Market Its Ferritin Assay for Clinical Chemistry Analyzers | news.sys-con.com
Diazymes Ferritin Assay provides an effective test method for laboratories of virtually all sizes, said Dr. Chong Yuan, Managing Director of Diazyme Laboratories. The sensitivity of the assay allows ferritin levels to be measured very efficiently and effectively. This high-throughput liquid stable assay provides precise test results, is user friendly, cost effective and has excellent correlation to the existing commercial methods. Diazyme Laboratories is a division of General Atomics headquartered in La Jolla, California. Diazyme uses its enzyme platform technologies to develop innovative assays for clinical and research uses with reduced costs and improved performance. Products include diagnostic blood tests for cardiac markers, diabetes, nutritional assessment, liver disease, renal disease and electrolytes. Information regarding Diazymes enzyme technology and related products can be found on its website at www.diazyme.com. ...
http://news.sys-con.com/node/3117439
Serum ferritin level - Restless Legs Syndrome | HealthUnlockedSerum ferritin level - Restless Legs Syndrome | HealthUnlocked
Hi everyone, I have had my blood test results. Please could anyone tell me if these results are ok for someone with rls - Serum ferritin level (XE24r) 56ug/L [30.0 - 400.0] Gobblededook! Receptionist...
https://healthunlocked.com/rlsuk/posts/135850538/serum-ferritin-level
Hydrogen Peroxide Formation during Iron Deposition in Horse Spleen Ferritin Using O 2 as an Oxidant †Hydrogen Peroxide Formation during Iron Deposition in Horse Spleen Ferritin Using O 2 as an Oxidant †
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_bi001981v
Tes Lab Ferritin di Bandung Archives - Laboratorium KlinikTes Lab Ferritin di Bandung Archives - Laboratorium Klinik
Parahita Diagnostic Centre, Berpangalaman belasan tahun dengan ratusan tenaga ahli berpengalaman, siap memberikan pelayanan terbaik untuk kamu yang membutuhkan pemeriksaan Ferritin di kota surabaya,sidoarjo,gresik,jember,banyuwangi,solo,yogyakarta,bandung,bekasi,jakarta,tangerang,makassar,malang , apa itu Ferritin?, Kita ikuti penjelasannya dibawah. FERRITIN ADALAH Ferritin adalah sebuah protein yang terbisa di dalam sel pada hampir seluruh makhluk hidup. Ferritin merupakan protein penyimpan zat…. ...
http://labparahita.com/en/tag/tes-lab-ferritin-di-bandung/
Tes Darah Ferritin di Makassar Archives - Laboratorium KlinikTes Darah Ferritin di Makassar Archives - Laboratorium Klinik
Parahita Diagnostic Centre, Berpangalaman belasan tahun dengan ratusan tenaga ahli berpengalaman, siap menghasilkan pelayanan terbaik untuk kamu yang membutuhkan pemeriksaan Ferritin di kota surabaya,sidoarjo,gresik,jember,banyuwangi,solo,yogyakarta,bandung,bekasi,jakarta,tangerang,makassar,malang , apa itu Ferritin?, Kita ikuti penjelasannya dibawah. FERRITIN ADALAH Ferritin adalah sebuah protein yang terdapat di dalam sel pada hampir seluruh makhluk hidup. Ferritin merupakan protein penyimpan zat…. ...
http://labparahita.com/en/tag/tes-darah-ferritin-di-makassar/
Lysosomal membrane permeabilization causes oxidative stress and ferritin induction in macrophagesLysosomal membrane permeabilization causes oxidative stress and ferritin induction in macrophages
Moderate lysosomal membrane permeabilization (LMP) is an important inducer of apoptosis. Macrophages are professional scavengers and are rich in hydrolytic enzymes and iron. In the present study, we found that LMP by lysosomotropic detergent MSDH resulted in early up-regulation of lysosomal cathepsins, oxidative stress and ferritin up-regulation, and cell death. Lysosomotropic base NH(4)Cl reduced the ferritin induction and oxidative stress in apoptotic cells induced by MSDH. Cysteine cathepsin inhibitors significantly protected cell death and oxidative stress, but had less effect on ferritin induction. We conclude that oxidative stress induced by lysosomal rupture causes ferritin induction with concomitant mitochondrial damage, which are the potential target for prevention of cellular oxidative stress and cell death induced by typical lysosomotropic substances in different disorders.. ...
http://liu.diva-portal.org/smash/record.jsf?pid=diva2:399237
Hemoglobin and iron status in mothers and their babies at delivery - Virtual Health Sciences Library
Of the mothers, we classified 10 [5%] as having iron deficiency anaemia. The haemoglobin concentration and MCV were higher in the neonates than in their mothers but the MCHC was no different. Serum iron was much higher and total iron binding capacity much lower in the babies whose transferrin saturation was 72% compared with 14% for their mothers. There was a weak relationship between maternal and neonatal haemoglobin concentration and a direct relationship between fetal and maternal serum iron, but no relationship between maternal and fetal serum ferritin concentrations. It is suggested that it is the fetus which largely controls the movement of iron across the placenta with only a little control exerted by maternal serum iron level, and that cord ferritin is not a good indicator of fetal iron stores ...
https://vlibrary.emro.who.int/imemr/hemoglobin-and-iron-status-in-mothers-and-their-babies-at-delivery-2/
ferritin and hemosiderin MRI - Questions and Answers ​in MRI
Ferritin is the principal iron storage molecule found in animal cells. It is a globular protein complex about 10 nm in diameter composed of 24 subunits arranged as a hollow shell (apoferritin) in which iron atoms can be packed. A typical ferritin molecule contains about 2000 iron atoms at its core, but potentially may hold up to 4500. Pores are present on the surface of the complex allowing iron atoms to enter and be released from the core. In this manner ferritin is able to regulate levels of intracellular iron ...
http://mri-q.com/ferritinhemosiderin.html
Validity of plasma collection cards for ferritin assessment-A proof-of-concept study<...
TY - JOUR. T1 - Validity of plasma collection cards for ferritin assessment-A proof-of-concept study. AU - Koehler, Karsten. AU - Marks-Nelson, Eileen. AU - Braga, Camila P.. AU - Beckford, Safiya. AU - Adamec, Jiri. PY - 2020/6/1. Y1 - 2020/6/1. N2 - Objectives: Iron depletion is common around the world and among certain risk groups in developed countries. The overall purpose was to test the suitability of a novel plasma collection card for minimally invasive iron status assessment. Methods: Twenty participants (10 f/10 m) participated in this cross-sectional study. Ferritin and hemoglobin were measured from blood collected from a forearm vein, serving as reference method. Blood was also collected from the fingertip using the NoviplexTM Plasma Prep Card as well as capillary collection tubes. Results: There was substantial concordance between ferritin measured from samples collected via NoviplexTM and venous ferritin (concordance correlation coefficient (CCC) = 0.96) with a mean bias of −0.8 ...
https://experts.nebraska.edu/en/publications/validity-of-plasma-collection-cards-for-ferritin-assessmenta-proo
Significance of low serum ferritin levels in elderly in-patients. | Postgraduate Medical JournalSignificance of low serum ferritin levels in elderly in-patients. | Postgraduate Medical Journal
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
http://pmj.bmj.com/content/69/817/892.1
About - Mayo ClinicAbout - Mayo Clinic
To diagnose a medical condition. Your doctor may suggest a ferritin test if other blood tests have shown that the level of oxygen-carrying protein in your red blood cells (hemoglobin) is low, or if the proportion of red blood cells to the fluid component in your blood (hematocrit) is low. These may indicate that you have iron deficiency anemia. A ferritin test can help confirm that diagnosis. Ferritin may also be measured in someone with restless legs syndrome.. A ferritin test may also be used to help diagnose conditions such as hemochromatosis, liver disease and adult Stills disease, among others.. When used to diagnose a medical condition, a ferritin test may be done in conjunction with an iron test and a total iron-binding capacity (TIBC) and transferrin test. These tests provide additional information about how much iron is in your body.. ...
https://www.mayoclinic.org/tests-procedures/ferritin-test/about/pac-20384928?reDate=28072016&p=1
HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: a genotype-stratified cohort study of...
Background and Aim: Women who are homozygous for the p.C282Y mutation in the HFE gene are at much lower risk of iron overload-related disease than p.C282Y homozygous men, presumably because of the iron-depleting effects of menstruation and pregnancy. We used data from a population cohort study to model the impact of menstruation cessation at menopause on serum ferritin (SF) levels in female p.C282Y homozygotes, with p.C282Y/p.H63D simple or compound heterozygotes and those with neither p.C282Y nor p.H63D mutations (HFE wild types) as comparison groups. Methods: A sample of the Melbourne Collaborative Cohort Study was selected for the HealthIron study (n = 1438) including all HFE p.C282Y homozygotes plus a random sample stratified by HFE-genotype (p.C282Y and p.H63D). The relationship between the natural logarithm of SF and time since menopause was examined using linear mixed models incorporating spline smoothing. Results: For p.C282Y homozygotes, SF increased by a factor of 3.6 (95% CI (1.8, ...
https://espace.library.uq.edu.au/view/UQ:547558
Large-Scale Iron Testing Feasible for Blood Centers - Transfusion NewsLarge-Scale Iron Testing Feasible for Blood Centers - Transfusion News
Iron deficiency is a common problem among frequent blood donors. The Canadian Blood Services recently sought to identify donors at highest risk of iron deficiency and the feasibility of large-scale ferritin testing. Over 1.5 years, ferritin testing was performed on 12,595 blood donors (2.6% of all donors) who had passed the hemoglobin screen. Donors with low ferritin levels (,25 µg/L) were informed of their low iron stores and advised to see their health care providers to ensure iron levels returned to normal. They were also advised not to donate blood for at least 6 months. Iron deficiency (,25 µg/L ferritin) was identified in 54% of female donors and 33% of male donors. Furthermore, over 41% of repeat male donors and 65% of repeat female donors had low iron levels. Almost 60% of donors deferred for low iron returned to donate within a year, but they donated less often and had a lower return rate compared to donors with normal iron levels. Since female donors are more prone to have low iron ...
http://transfusionnews.com/2017/03/29/large-scale-iron-testing-feasible-for-blood-centers/
How to interpret your iron panel blood test for optimal energy and health » MENELITEHow to interpret your iron panel blood test for optimal energy and health » MENELITE
Iron, together with thyroid, is probably one of the things most improperly tested for. With thyroid, doctors only measure TSH, which gives you almost no clue of actual thyroid function. Similarly with iron, doctors mainly test ferritin and then prescribe iron supplementation or phlebotomy based on just one marker. Pretty dangerous if you ask me.. A quick story. There was a man with significantly elevated ferritin, yet he was anemic. The doctor prescribed phlebotomy for years and the patient just got worse and his ferritin barely dropped. After a couple of years he had to quit his job and was administrated to a psychiatric hospital. After more than a decade they did some more tests and concluded that he was very low in copper and ceruloplasmin, which is needed to mobilize iron (ferritin) from the tissue for utilization in the body. For many years the doctors mainly tested ferritin and prescribed phlebotomy, whereas his problem was not mobilizing the iron and thus he got severe iron buildup ...
https://men-elite.com/2020/01/22/how-to-interpret-your-iron-panel-blood-test-for-optimal-energy-and-health/
Correction: Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis | proLékaře.czCorrection: Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis | proLékaře.cz
1. Mumbauer S, Pascual J, Kolotuev I, Hamaratoglu F (2019) Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis. PLoS Genet 15(9): e1008396. https://doi.org/10.1371/journal.pgen.1008396 31568497. ...
https://www.prolekare.cz/casopisy/plos-genetics/2020-10-1/correction-ferritin-heavy-chain-protects-the-developing-wing-from-reactive-oxygen-species-and-ferroptosis-124317
Characterization of radical formation and iron oxidation/hydrolysis du by Yu Chen BarrettCharacterization of radical formation and iron oxidation/hydrolysis du by Yu Chen Barrett
The functional roles of ferritin H and L subunits in ferrous iron oxidation and ferric iron hydrolytic polymerization were studied by combination of electrode oximetry and pH stat utilizing horse spleen and recombinant human H and L ferritins. Previous work has investigated ferrous ion oxidation kinetics, but no information on ferric core formation and its relationship to ferrous ion oxidation had been obtained. The kinetic pattern of iron oxidation/hydrolysis in H-chain homopolymer ferritin showed that the rate of iron hydrolysis is regulated by the rate of iron oxidation, and that both follow the iron ferroxidation pathway. In the early stage of the reaction with less than 10 Fe(II)/protein, it was observed that the stoichiometric ratio of proton release to ferrous iron consumption approaches zero, the ferrous iron to dioxygen ratio equals two and the kinetic ratio of proton release to dioxygen consumption approaches one. These results enable one to write a detailed mechanism for iron ferroxidation
https://scholars.unh.edu/dissertation/1811/
Iron Levels - Rogue Health and FitnessIron Levels - Rogue Health and Fitness
Ferritin is a protein that cells make in order to sequester and store iron.. Free iron, that is, iron that is unattached to any other chemical moiety, can catalyze dangerous chemical reactions that damage cell structures. The body therefore strives to keep free iron under control by attaching it to ferritin. While the correlation between excess body stores of iron and ferritin levels is not perfect, in most cases the result is close.. The major storage site of iron in the human body is not ferritin, however, it is hemoglobin, which is the oxygen-transporting molecule of red blood cells. Around 80% or so of total body iron is found in hemoglobin.. The difference between hemoglobin and ferritin when it comes to iron storage is that hemoglobin levels are, in most cases, kept within a narrow range. Exceptions: in anemia, not enough hemoglobin is made, iron deficiency anemia being the most common form. In polycythemia, too many red cells are made and thus theres too much hemoglobin. Therefore, for ...
http://roguehealthandfitness.com/iron-levels/?print=print
Need for iron supplementation in infants on prolonged breast feeding | Meta
Iron status, as measured by blood counts and indices, serum iron, transferrin saturation, and serum ferritin values, was studied longitudinally in 56 infants on prolonged breast feeding, and compared to that of 29 infants receiving cow milk formula prepared at home and of 47 infants receiving a proprietary infant formula. The first two groups received no iron supplementation, whereas the proprietary formula was supplemented with iron. Although breast feeding was found to be sufficient to meet iron needs during the first 6 months of life, supplemental iron would be necessary during the second half of infancy in order to guarantee the optimal iron status. ...
https://www.meta.org/papers/need-for-iron-supplementation-in-infants-on/671150
Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral...Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral...
There is evidence from the clinical literature of iron accumulation in the CNS of patients with ALS (Oba et al., 1993; Imon et al., 1995; Kasarskis et al., 1995). Although this has been known for some time, direct evidence of a role for iron in ALS has not been demonstrated thus far. Our data provide clear evidence that iron accumulation occurs in both neurons and glia but that different molecular mechanisms may contribute to iron accumulation in these two cell types. In glia, the increase in TfR1 that is likely to be mediated by the increase in IRP1 binding activity may underlie the influx of iron into these cells. Normally, IRP1 would be expected to concomitantly reduce the expression of ferritin (Pantopoulos, 2004). However, cytosolic ferritin expression goes up mainly in microglia, which could acquire iron from phagocytosis of dead and dying cells. Cytosolic ferritin mRNA expression is also known to be increased by proinflammatory cytokines or nitric oxide (Torti et al., 1988; Wei et al., ...
http://www.jneurosci.org/content/29/3/610.long
Most recent papers with the keyword CT colonoscopy | Read by QxMDMost recent papers with the keyword CT colonoscopy | Read by QxMD
Anemia in older adults is a risk factor for numerous negative outcomes. There is no standard definition, but in most studies, anemia is defined as a hemoglobin value ,12 g/dL for women and ,13 g/dL for men. Absolute iron deficiency anemia is defined as the combination of anemia and the absence of total body iron. Serum ferritin is the most frequently used diagnostic parameter, but its concentration increases with age and in the presence of inflammatory diseases. Other laboratory tests, such as transferrin saturation, soluble transferrin receptor and the soluble transferrin receptor/ferritin index might provide useful information, but there is a wide variety in the cut-off values and interpretation of the results ...
https://www.readbyqxmd.com/keyword/105779
Serum Ferritin as a Predictor of Glaucoma in the South Korean Population | IOVS | ARVO JournalsSerum Ferritin as a Predictor of Glaucoma in the South Korean Population | IOVS | ARVO Journals
Participants whose serum ferritin level was greater than 62 ng/ml had significantly higher odds of a glaucoma diagnosis when compared to those with a level less than 30 ng/ml, after adjustment for potential confounders (odds ratio [OR] 1.19, 95% confidence interval [CI] 0.806-1.758 for levels 31-61 ng/ml; OR 1.608, 95% CI 1.115-2.319 for levels 62-112 ng/ml; OR 1.892, 95% CI 1.279-2.800 for levels 113-3018 ng/ml).. ...
https://iovs.arvojournals.org/article.aspx?articleid=2269778&resultClick=1
The absence of H-2 antigens from mouse pancreatic beta-cells demonstrated by immunoferritin labeling. | JEMThe absence of H-2 antigens from mouse pancreatic beta-cells demonstrated by immunoferritin labeling. | JEM
Islets of Langerhans were isolated from mouse pancreases and fixed in periodatelysine-paraformaldehyde. The fixed islets were then dissociated with trypsin and EDTA to yield cell suspensions that contained mainly four cell types; beta-cells, capillary endothelial cells, acinar cells, and pancreatic duct epithelial cells. The nonislet cells were probably associated wtih the surface of the isolated islets. The H-2 antigens of the dissociated pancreatic cells were labeled with an immunoferritin technique. Pancreatic duct epithelial cells showed specific ferritin labeling on their lateral cell membranes but not on apical microvillus membranes. Acinar cells were also labeled on lateral membranes, and the capillary endothelial cells were labeled on both the luminal and albuminal aspects of their surface membranes. In contrast, pancreatic beta-cells were unlabeled. The number of ferritin molecules per unit length of beta-cell membrane was essentially the same on cells from the antigenic strain and the ...
http://jem.rupress.org/content/150/1/1
MJB Journal : Salivary Iron And Ferritin Levels, Orofacial Complications of Patients With Thalassemia Major In Babylon Teaching...MJB Journal : Salivary Iron And Ferritin Levels, Orofacial Complications of Patients With Thalassemia Major In Babylon Teaching...
Medicine Journal in MJB authors are : Mahdi Yakoob Kzar,Ali Mihsen Hussein Salivary Iron And Ferritin Levels, Orofacial Complications of Patients With Thalassemia Major In Babylon Teaching Hospital For Maternity and Children university of babylon journals in the repository for farther content please log to http://repository.uobabylon.edu.iq
http://www.medicaljb.com/article.aspx?jrid=1286
LIVER IRON CONTENT (LIC) IN ADULTS WITH NON-TRANSFUSION DEPENDENT SICKLE CELL DISEASE (NT-SCD). CORRELATION WITH SERUM FERRITIN...LIVER IRON CONTENT (LIC) IN ADULTS WITH NON-TRANSFUSION DEPENDENT SICKLE CELL DISEASE (NT-SCD). CORRELATION WITH SERUM FERRITIN...
LIVER IRON CONTENT (LIC) IN ADULTS WITH NON-TRANSFUSION DEPENDENT SICKLE CELL DISEASE (NT-SCD). CORRELATION WITH SERUM FERRITIN AND LIVER ENZYMES CONCENTRATIONS
http://www.mjhid.org/index.php/mjhid/article/view/2017.037
The Langerhans cell granule is an adsorptive endocytic organelle<...
TY - JOUR. T1 - The Langerhans cell granule is an adsorptive endocytic organelle. AU - Takigawa, M.. AU - Iwatsuki, K.. AU - Yamada, M.. AU - Okamoto, H.. AU - Imamura, S.. PY - 1985. Y1 - 1985. N2 - The role of Langerhans cell granules (LCG) in adsorptive endocytosis was studied by using concanavalin A (Con A) and heterologous anti-epidermal cell serum (AES) as ligands. Isolated epidermal cells were obtained by trypsinization of guinea pig skin fragments and exposed to ferritin-conjugated Con A or AES followed by ferritin-conjugated second antibody at 37°C for various times up to 30 min. Langerhans cells among the treated epidermal cells were observed by electron microscopy. Shortly after the incubation, a few LCG in the cell periphery were filled with ferritin particles in the bulb portion. After prolonged incubation, ferritin-containing LCG increased in number and seemed to move to the juxtanuclear area. The granules were derived from plasma membrane invaginations that collected ferritin ...
https://okayama.pure.elsevier.com/en/publications/the-langerhans-cell-granule-is-an-adsorptive-endocytic-organelle
Beaumont Laboratory - Lab Test Details
The concentration of Soluble Transferrin Receptor (sTfR) is an indicator of iron status. Iron deficiency causes overexpression of transferrin receptor and sTfR levels, while iron repletion results in decreased sTfR levels. sTfR levels should be used to evaluate suspected iron deficiency in patients who may have inflammation, infection or chronic disease and other conditions in which ferritin concentration does not correlate with iron status. ...
http://beaumontlaboratory.com/test-lab-directory/lab-test-details/?testid=1803
Haemochromatosis treatment | The London ClinicHaemochromatosis treatment | The London Clinic
Haemochromatosis treatment is straightforward. It involves taking blood a pint at a time to deplete the bodys iron stores in a procedure called venesection. A typical schedule could involve taking a pint of blood each week until serum ferritin levels are at the lower end of the normal range.
https://www.thelondonclinic.co.uk/treatments/haemochromatosis-diagnosis-and-treatment
Soluble Transferrin Receptor Blood Test | Walk-In LabSoluble Transferrin Receptor Blood Test | Walk-In Lab
Order a Soluble Transferrin Receptor Blood Test to measure sTfR to diagnose iron deficiency in individuals with chronic disease, many of whom are Anemic.
https://www.walkinlab.com/products/view/soluble-transferrin-receptor-blood-test
New Metamaterials Produced By Combining Synthetic And Biological Nanoparticles - RedorbitNew Metamaterials Produced By Combining Synthetic And Biological Nanoparticles - Redorbit
Aalto University. Scientists from Aalto University, Finland, have succeeded in organizing virus particles, protein cages and nanoparticles into crystalline materials. These nanomaterials studied by the Finnish research group are important for applications in sensing, optics, electronics and drug delivery.. Layer structures, or superlattices, of crystalline nanoparticles have been extensively studied in recent years. The research develops hierarchically structured nanomaterials with tuneable optical, magnetic, electronic and catalytic properties.. Such biohybrid superlattices of nanoparticles and proteins would allow the best features of both particle types to be combined. They would comprise the versatility of synthetic nanoparticles and the highly controlled assembly properties of biomolecules.. The research group also discovered magnetic self-assemblies of ferritin protein cages and gold nanoparticles. These magnetic assemblies can modulate efficiently spin-spin relaxation times of surrounding ...
http://www.redorbit.com/news/science/1112751509/metamaterials-produced-combining-synthetic-biological-nanoparticles-121912/
Body iron status and gastric cancer risk in the EURGAST study<...
TY - JOUR. T1 - Body iron status and gastric cancer risk in the EURGAST study. AU - Fonseca-Nunes, A.. AU - Agudo, A.. AU - Aranda, N.. AU - Arija, V.. AU - Cross, A. J.. AU - Molina, E.. AU - Sanchez, M. J.. AU - Bueno-de-Mesquita, H. B.. AU - Siersema, P.. AU - Weiderpass, E.. AU - Krogh, V.. AU - Mattiello, A.. AU - Tumino, R.. AU - Saieva, C.. AU - Naccarati, A.. AU - Ohlsson, B.. AU - Sjoberg, K.. AU - Boutron-Ruault, M. C.. AU - Cadeau, C.. AU - Fagherazzi, G.. AU - Boeing, H.. AU - Steffen, A.. AU - Kuhn, T.. AU - Katzke, V.. AU - Tjonneland, A.. AU - Olsen, A.. AU - Khaw, K. T.. AU - Wareham, N.. AU - Key, T.. AU - Riboli, E.. AU - Peeters, P. H.. AU - Gavrila, D.. AU - Dorronsoro, M.. AU - Quiros, J. R.. AU - Barricarte, A.. AU - Jenab, M.. AU - Zamora-Ros, R.. AU - Freisling, H.. AU - Trichopoulou, A.. AU - Lagiou, P.. AU - Bamia, C.. AU - Jakszyn, P.. PY - 2015/10/9. Y1 - 2015/10/9. N2 - Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, ...
https://pure.qub.ac.uk/en/publications/body-iron-status-and-gastric-cancer-risk-in-the-eurgast-study
Membrane-bound and fluid-phase macromolecules enter separate prelysosomal compartments in absorptive cells of suckling rat...Membrane-bound and fluid-phase macromolecules enter separate prelysosomal compartments in absorptive cells of suckling rat...
The absorptive cell of the suckling rat ileum is specialized for the uptake and digestion of milk macromolecules from the intestinal lumen. The apical cytoplasm contains an extensive tubulocisternal system, a variety of vesicles and multivesicular bodies (MVB), and a giant phagolysosomal vacuole where digestion is completed. To determine if sorting of membrane-bound and fluid-phase macromolecules occurs in this elaborate endocytic system, we infused adsorptive and soluble tracers into ligated intestinal loops in vivo and examined their fates. Lysosomal compartments were identified by acid phosphatase histochemistry. Native ferritin and two ferritin-lectin conjugates that do not bind to ileal membranes (Con A, UEAI) served as soluble tracers. Horseradish peroxidase binds to ileal membranes and thus was not useful as a fluid-phase tracer in this system. Cationized ferritin and a lectin that binds to terminal B-D-galactosyl sites on ileal membranes (Ricinus communis agglutinin [RCAI]-ferritin) were ...
https://rupress.org/jcb/article/99/3/909/21042/Membrane-bound-and-fluid-phase-macromolecules
DSpace at KOASAS: Development of functionalized nanoparticles for immunoassay and gene delivery = 면역분석과 유전자 전달을 위한 기능성 나노입자의 개발...DSpace at KOASAS: Development of functionalized nanoparticles for immunoassay and gene delivery = 면역분석과 유전자 전달을 위한 기능성 나노입자의 개발...
Nanoparticles have been widely used in biological and biomedical fields. To achieve certain purpose, nanoparticles should be functionalized with diverse molecules through genetic or chemical modification. Therefore, we developed genetically functionalized nanoparticles for improved systems by simple construction. In chapter 1, we developed genetically functionalized ferritin nanoparticles for immunoassay and imaging. Ferritins are known as self-assembled protein nanoparticles, and we fused human IgG-specific repebody to N-terminal heavy-chain ferritin subunit to construct repebody-ferritin nanoparticles. The repebody-ferritin nanoparticles were shown to have a three-order of magnitude higher binding affinity toward human IgG than free repebody due to multivalency. Also, the dye-labeled repebody-ferritin nanoparticles were applied for immunoassay such as western blot, cell imaging and flow cytometry. As a result, the repebody-ferritin nanoparticles generated much stronger fluorescent signals than ...
https://koasas.kaist.ac.kr/handle/10203/241743?mode=full
African iron overloadAfrican iron overload
Ferritin level above 200 ng/mL (449 pmol/L) in women or 300 ng/mL (674 pmol/L) in men who have no signs of inflammatory disease ... Serum ferritin concentration is likely to be high in persons with Q248H (mostly heterozygotes) than in wild-type SLC40A1. In ... Measurement of serum ferritin indicates for total body iron overload. Liver biopsy measures the iron concentration of liver. It ... "Ferritin". MedlinePlus. Retrieved 9 April 2014. "Iron (Fe)". Web MD. Retrieved 9 April 2014. McLaren, CE; Barton, JC; Adams, PC ...
https://en.wikipedia.org/wiki/African_iron_overload
AnemiaAnemia
serum ferritin; This protein helps store iron in the body, a low levels of ferritin usually indicates a low levels of stored ...
https://en.wikipedia.org/wiki/Anemia
OsseointegrationOsseointegration
Bernard, George W.; Carranza, Ferritin A.; Jovanovic, Sascha A. (1996). "Biologic Aspects of Dental Implants". In Carranza, ...
https://en.wikipedia.org/wiki/Osseointegration
Hemochromatosis type 4Hemochromatosis type 4
More ferritin is produced to suppress oxidative cell damage, although the amount of ferritin that cells can accumulate is ... Blood tests may show high levels of ferritin and low, normal, or high levels of transferrin saturation, depending on the form ... Iron accumulates preferentially in Kupffer cells, which are located in the liver, and serum ferritin increases; less iron is ... Iron is stored in cells and blood serum in a protein called ferritin. Reticuloendothelial macrophages, which can phagocytose ...
https://en.wikipedia.org/wiki/Hemochromatosis_type_4
Quantum mindQuantum mind
... tissue and the presence of disordered arrays of ferritin in SNc tissue. The hypothesis also predicted that disordered ferritin ... The hypothesis is based in part on the observation by many independent researchers that electron tunneling occurs in ferritin, ... Rourk, Christopher John (September 2018). "Ferritin and neuromelanin "quantum dot" array structures in dopamine neurons of the ... "Electrical Conductivity of Ferritin Proteins by Conductive AFM". Nano Letters. 5 (4): 571-577. Bibcode:2005NanoL...5..571X. doi ...
https://en.wikipedia.org/wiki/Quantum_mind
Assisted reproductive technologyAssisted reproductive technology
In IVF and ICSI, a risk factor is the decreased expression of proteins in energy metabolism; Ferritin light chain and ATP5A1. ...
https://en.wikipedia.org/wiki/Assisted_reproductive_technology
BiomineralizationBiomineralization
H2O in the protein ferritin). In terms of taxonomic distribution, the most common biominerals are the phosphate and carbonate ...
https://en.wikipedia.org/wiki/Biomineralization
Bioinorganic chemistryBioinorganic chemistry
The metal micronutrients are taken up into organisms by specific transporters and bound to storage proteins such as ferritin or ... the protein ferritin plays an important role in controlling the distribution of iron. The abundant inorganic elements act as ... ferritin), and small molecules (e.g. siderophores) are employed to control metal ions concentration and bio-availability in ... H2O in the protein ferritin). Because extracellular iron is strongly involved in inducing calcification, its control is ...
https://en.wikipedia.org/wiki/Bioinorganic_chemistry
Neural bindingNeural binding
... tissue and the presence of disordered arrays of ferritin in SNc tissue. The hypothesis also predicted that disordered ferritin ... Ho, Ru-Hung; Chen, Yu-Hung; Wang, Chong Mou (June 2012). "Surface differentiation of ferritin and apoferritin with atomic force ... Rourk, Christopher John (September 2018). "Ferritin and neuromelanin "quantum dot" array structures in dopamine neurons of the ... "Electrical Conductivity of Ferritin Proteins by Conductive AFM". Nano Letters. 5 (4): 571-577. doi:10.1021/nl048218x. ISSN 1530 ...
https://en.wikipedia.org/wiki/Neural_binding
Binding problemBinding problem
Further experiments have shown that ferritin structures similar to ones found in SNc tissue are able to conduct electrons over ... Experiments have shown that ferritin and neuromelanin in fixed human substantia nigra pars compacta (SNc) tissue are able to ... Both of these observations are consistent with earlier predictions that are part of a hypothesis that ferritin and neuromelanin ... Rourk, Christopher John (September 2018). "Ferritin and neuromelanin "quantum dot" array structures in dopamine neurons of the ...
https://en.wikipedia.org/wiki/Binding_problem
Iron overloadIron overload
If the serum ferritin is greater than 1000 ug/L at diagnosis there is a risk of liver damage and cirrhosis which may eventually ... Once the serum ferritin and transferrin saturation are within the normal range, treatments may be scheduled every two to three ... Serum ferritin testing is a low-cost, readily available, and minimally invasive method for assessing body iron stores. However ... Ferritin by: Mark Levin, MD, Hematologist and Oncologist, Newark, NJ. Review provided by VeriMed Healthcare Network Andrea ...
https://en.wikipedia.org/wiki/Iron_overload
Iron-binding proteinsIron-binding proteins
Ferritin is an iron reservoir for an individual cell. It is found in all cells types and localized in the cytosol. Ferritin is ... Ferritin is used to diagnose low iron levels in humans. It can be used to indicate the level of bioavailable iron, which is ... Ferritin is a highly conserved protein through all domains of life. It is so conserved that subunits from horses and humans can ... "What Is a Ferritin Blood Test? What Do the Results Mean?". WebMD. Retrieved 2018-11-11. (Iron metabolism). ...
https://en.wikipedia.org/wiki/Iron-binding_proteins
DNA-binding protein from starved cellsDNA-binding protein from starved cells
Bacterioferritin Transferrin Ferritin Ilari A, Stefanini S, Chiancone E, Tsernoglou D (January 2000). "The dodecameric ferritin ... A ferritin-like DNA-binding protein of Escherichia coli". The Journal of Biological Chemistry. 277 (31): 27689-96. doi:10.1074/ ... Grant RA, Filman DJ, Finkel SE, Kolter R, Hogle JM (April 1998). "The crystal structure of Dps, a ferritin homolog that binds ... Dps proteins belong to the ferritin superfamily and the DNA protection is afforded by means of a double mechanism: The first ...
https://en.wikipedia.org/wiki/DNA-binding_protein_from_starved_cells
Iron in biologyIron in biology
Dysfunctional ferritin may accumulate as hemosiderin, which can be problematic in cases of iron overload. The ferritin storage ... Iron can be stored in ferritin as ferric iron due to the ferroxidase activity of the ferritin heavy chain. ... Both ferritin and ferroportin contain an IRE in their 5' UTRs, so that under iron deficiency their translation is repressed by ... At the bone marrow, transferrin is reduced from Fe3+ and Fe2+ and stored as ferritin to be incorporated into hemoglobin. The ...
https://en.wikipedia.org/wiki/Iron_in_biology
Human iron metabolismHuman iron metabolism
Dysfunctional ferritin may accumulate as hemosiderin, which can be problematic in cases of iron overload. The ferritin storage ... Iron can be stored in ferritin as ferric iron due to the ferroxidase activity of the ferritin heavy chain. ... Both ferritin and ferroportin contain an IRE in their 5' UTRs, so that under iron deficiency their translation is repressed by ... The liver stores of ferritin are the primary physiologic source of reserve iron in the body. The reserves of iron in ...
https://en.wikipedia.org/wiki/Human_iron_metabolism
Latent iron deficiencyLatent iron deficiency
The ideal would be to increase the deposits of body iron, measured as levels of ferritin in serum, trying to achieve a ferritin ... Serum ferritin levels reflect the iron stores available in the body. The normal range is 20 to 200 ng/mL for men and 15 to 150 ... With ferritin levels higher than 100 ng/mL an increase in infections, etc. has been reported. Another way to treat LID is with ... Serum ferritin falls to less than 20 ng/mL. Increased iron absorption, a compensatory change, results in an increased amount ...
https://en.wikipedia.org/wiki/Latent_iron_deficiency
Quantum spin tunnelingQuantum spin tunneling
Quantum tunneling of the magnetization was reported in ferritin present in horse spleen proteins A direct measurement of the ... "Macroscopic Resonant Tunneling of Magnetization in Ferritin". Physical Review Letters. 79 (9): 1754-1757. Bibcode:1997PhRvL.. ...
https://en.wikipedia.org/wiki/Quantum_spin_tunneling
Anemia of chronic diseaseAnemia of chronic disease
... ferritin is normal or high, reflecting the fact that iron is sequestered within cells, and ferritin is being produced as an ... In iron deficiency anemia ferritin is low. Total iron-binding capacity (TIBC) is high in iron deficiency, reflecting production ...
https://en.wikipedia.org/wiki/Anemia_of_chronic_disease
Beta thalassemiaBeta thalassemia
Serum ferritin (the storage form of iron) is routinely measured in those with beta thalassemia to determine the degree of iron ... These tests include complete blood count; hemoglobin electrophoresis; serum transferrin, ferritin, total iron-binding capacity ... in adults with transfusion dependent beta thalassemia as compared to placebo and was also associated with decreased ferritin ... overload; with increased ferritin levels directing the use of iron chelation therapy. The three iron chelators; subcutaneous ...
https://en.wikipedia.org/wiki/Beta_thalassemia
Congenital dyserythropoietic anemiaCongenital dyserythropoietic anemia
This is true for ferritin levels and iron levels in the organs as well, it is important for patients to go regularly for ... "Ferritin: Reference Range, Interpretation, Collection and Panels". 2018-07-05. {{cite journal}}: Cite journal requires ,journal ... than to simply get regular blood tests to check ferritin levels, which only show a trend, and do not reflect actual organ iron ... hematologists generally do not begin chelation therapy until ferritin levels reach at least 1000 ng/ml. It is more important to ...
https://en.wikipedia.org/wiki/Congenital_dyserythropoietic_anemia
MagnetogeneticsMagnetogenetics
The ferritin is composed of 24 subunits of protein complex and a small iron oxide core. The core of the ferritin is in the form ... There has been attempts to overcome these intrinsic physical limits of the ferritin. One approach is the use of magnetic ... Jutz G, van Rijn P, Santos Miranda B, Böker A (February 2015). "Ferritin: a versatile building block for bionanotechnology". ... One approach involves synthesizing the fusion protein of ion channels with iron containing proteins such as ferritins to ...
https://en.wikipedia.org/wiki/Magnetogenetics
Intracellular deliveryIntracellular delivery
Feldherr, C M (1962). "The Intracellular Distribution of Ferritin Following Microinjection". J Cell Biol. 12 (1): 159-167. doi: ... Examples include amoeba microinjected with ferritin and mouse eggs microinjected with bovine albumin. Because proteins have ...
https://en.wikipedia.org/wiki/Intracellular_delivery
Endothelial NOSEndothelial NOS
Balla G, Jacob HS, Balla J, Rosenberg M, Nath K, Apple F, Eaton JW, Vercellotti GM (Sep 1992). "Ferritin: a cytoprotective ... Furthermore, part of antioxidants properties of NO is attributable to up-regulation of heme-oxygenase-I and ferritin expression ...
https://en.wikipedia.org/wiki/Endothelial_NOS
Ferric maltolFerric maltol
It is also bound to ferritin for storage. Maltol reaches its highest plasma concentrations after 1 to 1.5 hours. It is quickly ...
https://en.wikipedia.org/wiki/Ferric_maltol
Iron deficiencyIron deficiency
Serum ferritin can be elevated in inflammatory conditions; so a normal serum ferritin may not always exclude iron deficiency, ... Low serum ferritin (see below) Low serum iron High TIBC (total iron binding capacity), although this can be elevated in cases ... and the utility is improved by taking a concurrent C-reactive protein (CRP). The level of serum ferritin that is viewed as " ...
https://en.wikipedia.org/wiki/Iron_deficiency
Iron-deficiency anemiaIron-deficiency anemia
A low serum ferritin is most commonly found. However, serum ferritin can be elevated by any type of chronic inflammation and ... These stores are called ferritin complexes and are part of the human (and other animals) iron metabolism systems. Men store ... Mazza J, Barr RM, McDonald JW, Valberg LS (October 1978). "Usefulness of the serum ferritin concentration in the detection of ... ferritin) for a period of time, and red blood cell formation continues normally. However, as these stores continue to be used, ...
https://en.wikipedia.org/wiki/Iron-deficiency_anemia
Universal coronavirus vaccineUniversal coronavirus vaccine
It uses a ferritin nanoparticle with prefusion-stabilized spike antigens from the Wuhan strain. Another candidates is RBD-scNP ... It uses a spike ferritin-based nanoparticle (SpFN). This vaccine began a Phase I clinical trial in April 2022. Another is to ... which is a sortase A-conjugated ferritin nanoparticle with RBD antigens. ,GRT-R910 is a self-amplifying mRNA delivering spike ...
https://en.wikipedia.org/wiki/Universal_coronavirus_vaccine
NeuroferritinopathyNeuroferritinopathy
The protein ferritin functions to sequester and release iron, acting as an iron buffering system in cells. Iron is essential to ... Wild type ferritin functions as a buffer for iron, sequestering it and controlling its release. Thus, mutations in the light ... The insertion of bases into the L-chain ferritin gene causes the chain to lengthen and alter the sequence of the amino acids ... Ferritin aggregates found in the skin, liver, kidney, and muscle tissues may help in diagnosing neuroferritinopathy. More ...
https://en.wikipedia.org/wiki/Neuroferritinopathy
COVID-19 vaccineCOVID-19 vaccine
It uses a spike ferritin-based nanoparticle (SpFN). This vaccine began a Phase I clinical trial in April 2022. Another strategy ...
https://en.wikipedia.org/wiki/COVID-19_vaccine
Sideroblastic anemiaSideroblastic anemia
Serum iron, percentage saturation and ferritin are increased. The total iron-binding capacity of the cells is normal to ... Serum Iron: high increased ferritin levels decreased total iron-binding capacity high transferrin saturation Hematocrit of ...
https://en.wikipedia.org/wiki/Sideroblastic_anemia
Ferritin blood test: MedlinePlus Medical EncyclopediaFerritin blood test: MedlinePlus Medical Encyclopedia
The ferritin blood test measures the level of ferritin in the blood. ... Ferritin is a protein inside your cells that stores iron. It allows your body to use the iron when it needs it. A ferritin test ... The amount of ferritin in the blood (serum ferritin level) is directly related to the amount of iron stored in your body. Iron ... The ferritin blood test measures the level of ferritin in the blood. ...
https://medlineplus.gov/ency/article/003490.htm
NHANES 2009-2010: Ferritin Data Documentation, Codebook, and Frequencies
LBXFER - Ferritin (ng/mL). Variable Name: LBXFER SAS Label: Ferritin (ng/mL). English Text: Ferritin (ng/mL). Target: Both ... LBDFERSI - Ferritin (ug/L). Variable Name: LBDFERSI. SAS Label: Ferritin (ug/L). English Text: Ferritin (ug/L). Target: Both ... The 1st incubation uses 10 uL of sample, a ferritin-specific antibody and a labeled ferritin-specific antibody to form a ... A crossover study was performed to compare the 2009-2010 Ferritin data to the 2007-2008 Ferritin data. The Roche Hitachi 912 ...
https://wwwn.cdc.gov/Nchs/Nhanes/2009-2010/FERTIN_F.htm
Hemochromatosis Workup: Approach Considerations, Transferrin Saturation, Serum Ferritin StudiesHemochromatosis Workup: Approach Considerations, Transferrin Saturation, Serum Ferritin Studies
Serum Ferritin Studies. Ferritin levels are less sensitive than transferrin saturation in screening tests for hemochromatosis. ... Ferritin concentration can also be high in other conditions, such as infections, inflammations, and liver disease. Ferritin ... A ferritin level of greater than 1000 mcg/L is a strong and independent predictor of fibrosis, but when alcohol intake exceeds ... Serum ferritin levels elevated higher than 200 mcg/L in premenopausal women and 300 mcg/L in men and postmenopausal women ...
https://www.medscape.com/answers/177216-44043/what-is-the-significance-of-high-ferritin-levels-in-the-evaluation-of-hemochromatosis
Ferritin: Reference Range, Interpretation, Collection and PanelsFerritin: Reference Range, Interpretation, Collection and Panels
It is present in small concentrations in blood, and the serum ferritin concentration normally correlates well with total-body ... Ferritin is the cellular storage protein for iron. ... encoded search term (Ferritin) and Ferritin What to Read Next ... Iron is stored either as hemosiderin or ferritin. Ferritin is water-soluble, while hemosiderin is water-insoluble. Ferritin is ... Ferritin is the cellular storage protein for iron. It is present in small concentrations in blood, and the serum ferritin ...
https://emedicine.medscape.com/article/2085454
Suchen nach Schlagwort FerritinsSuchen nach Schlagwort "Ferritins"
Serum ferritin concentrations for the assessment of iron status in individuals and populations: technical brief  ... Serum ferritin concentrations for the assessment of iron status and iron deficiency in populations  ... WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations  ...
https://extranet.who.int/iris/restricted/browse?locale-attribute=de&type=mesh&authority=Ferritins
Medical Definition of FerritinMedical Definition of Ferritin
Ferritin: The major protein concerned with iron storage. The blood ferritin level serves as an indicator of the amount of iron ...
https://www.medicinenet.com/ferritin/definition.htm
RhymeZone: ferritin definitionsRhymeZone: ferritin definitions
Search for ferritin at other dictionaries: OneLook, Oxford, American Heritage, Merriam-Webster, Wikipedia. See ferritin used in ... Definitions of ferritin: *noun: a protein containing 20% iron that is found in the intestines and liver and spleen; it is one ...
https://www.rhymezone.com/r/d=ferritin
Ferritin - WikipediaFerritin - Wikipedia
All vertebrate ferritin genes have three introns and four exons.[7] In human ferritin, introns are present between amino acid ... Ferritin at Lab Tests Online. *Overview of all the structural information available in the PDB for UniProt: P02792 (Ferritin ... Plasma ferritin is also an indirect marker of the total amount of iron stored in the body; hence, serum ferritin is used as a ... If ferritin is high, there is iron in excess or else there is an acute inflammatory reaction in which ferritin is mobilized ...
https://en.m.wikipedia.org/wiki/Ferritin
Ferritin - a multifaceted protein scaffold for biotherapeutics | Experimental & Molecular MedicineFerritin - a multifaceted protein scaffold for biotherapeutics | Experimental & Molecular Medicine
We (i) introduce the application of ferritin in drug delivery; (ii) present an overview of the use of ferritin in imaging and ... review ferritin-based agents currently in clinical trials. Although there are no currently approved drugs based on ferritin, ... Ferritin can rapidly disperse, and release its contents steadily over a long time. It can deliver diagnostic imaging compounds ... Ferritin molecules, hollow protein spheres that store and release iron as needed, also hold promise for disease diagnosis, drug ...
https://www.nature.com/articles/s12276-022-00859-0?error=cookies_not_supported&code=2deaf8e7-5473-4cef-b8be-6ab983c74ca7
Ferritin high, RBC little low, iron in normal rangeFerritin high, RBC little low, iron in normal range
My ferritin is high its 506 in a range 11.0-264 and my iron is 46 range is 37-170 But TICB is ... ... My ferritin is high its 506 in a range 11.0-264 and my iron is 46 range is 37-170. But TICB is low 215 and range is 265-497. ... Your ferritin and iron saturation can go very high even though your iron is normal (or low) due to inflammation. So your high ...
https://www.healingwell.com/community/default.aspx?f=38&m=4269505
Human H Ferritin (HuHF) Assembly - LRSMHuman H Ferritin (HuHF) Assembly - LRSM
Human H Ferritin (HuHF) Assembly. J. Saven & I. J. Dmochowski. X-ray crystal structure of a designed human H ferritin and a ... Human H ferritin (HuHF) forms an assembly comprising 24 copies of a four-helix bundle protein. The resulting ~500 kDa protein ...
https://www.lrsm.upenn.edu/highlight/human-h-ferritin-huhf-assembly/
SCOPe 2.08: Fold a.25: Ferritin-likeSCOPe 2.08: Fold a.25: Ferritin-like
More info for Fold a.25: Ferritin-like. Timeline for Fold a.25: Ferritin-like: *Fold a.25: Ferritin-like first appeared (with ... hetero)dimer of alpha-hairpin subunits similar to that of the half-ferritin family; no bound metals inside the bundle. ... a.25.1: Ferritin-like [47240] (10 families) contains bimetal-ion centre in the middle of the bundle. ... hetero)dimer of alpha-hairpin subunits similar to that of the half-ferritin family; no bound metals. ...
https://scop.berkeley.edu/sunid=47239
Female Runners Should Be Aware of Ferritin Levels - Trail Runner MagazineFemale Runners Should Be Aware of Ferritin Levels - Trail Runner Magazine
What Is Ferritin?. Ferritin is a protein in which your body stores extra iron, says Meghann Featherstun, R.D., ... If a ferritin test reveals that your blood ferritin level is lower than that 40 ng/ml threshold, it indicates your bodys iron ... How to Fix Low Ferritin Levels. The best way to up your ferritin levels is to eat iron-rich foods like red meat and dark meat ... And "ferritin" is one of the most common ones to pop up for female runners. Even Keira DAmato has posted about addressing low ...
https://www.trailrunnermag.com/nutrition/female-runners-ferritin/?itm_source=parsely-api
Ferritin blood testFerritin blood test
Ferritin is a protein inside your cells that stores iron. Learn more about this test here. ... The ferritin blood test measures the level of ferritin in the blood. ... Ferritin is a protein inside your cells that stores iron. It allows your body to use the iron when it needs it. A ferritin test ... The amount of ferritin in the blood (serum ferritin level) is directly related to the amount of iron stored in your body. Iron ...
https://www.ucsfbenioffchildrens.org/medical-tests/ferritin-blood-test
NHANES 2000-2000: Cadmium, Lead, Ferritin, Serum Folate, RBC Folate, Vitamin B12, Homocysteine, Methylmalonic acid,...
LB2FER - Ferritin (ng/mL). Variable Name: LB2FER. SAS Label: Ferritin (ng/mL). English Text: Ferritin (ng/mL). Target: Both ... LB2FERSI - Ferritin (ug/L). Variable Name: LB2FERSI. SAS Label: Ferritin (ug/L). English Text: Ferritin (ug/L). Target: Both ... Ferritin Ferritin is measured by using the Bio-Rad Laboratories "QuantImune Ferritin IRMA" kit,6 which is a single-incubation ... and the ferritin antibodies are immobilized on polyacrylamide beads as the solid phase. Serum or ferritin standards (made from ...
https://wwwn.cdc.gov/Nchs/Nhanes/limited_access/L06_2_00.htm
WHO EMRO | Effects of iron supplementation and nutrition education on haemoglobin, ferritin and oxidative stress in iron...
Ferritin and MDA levels in group B were slightly higher than in the other 2 groups but no statistically significant differences ... The mean ferritin concentration also differed significantly between the timelines (P < 0.001). A post-hoc test using the ... There was a significant increase in the mean ferritin level in Groups A and B. This finding is consistent with the findings of ... 18,22). In our study, mean ferritin levels after 3 months of iron supplementation in group A changed from 9.9 (SD 3.16) µg/L to ...
https://www.emro.who.int/emhj-volume-24-2018/volume-24-issue-6/effects-of-iron-supplementation-and-nutrition-education-on-haemoglobin-ferritin-and-oxidative-stress-in-iron-deficient-female-adolescents-in-palestine-randomized.html
Can low ferritin levels explain breathlessness? - Page 9 - Fetcheveryone.comCan low ferritin levels explain breathlessness? - Page 9 - Fetcheveryone.com
Can low ferritin levels explain breathlessness? - Page 9 ... Can low ferritin levels explain breathlessness?. 17 watchers. ...
https://www.fetcheveryone.com/forum/can-low-ferritin-levels-explain-breathlessness-45618/
Ferritin Fe 5 mg- My Village GreenFerritin Fe 5 mg- My Village Green
Ecological Formulas Ferritin Bioavailable Iron Capsules contain a powerful formula that delivers 5 milligrams of ferritin ... Ferritin is the major iron storage protein in the body and provides the most bioavailable form of iron. ... Ecological Formulas Ferritin Bioavailable Iron Capsules contain a powerful formula that delivers 5 milligrams of ferritin ... Ferritin is the major iron storage protein in the body and provides the most bioavailable form of iron. ...
https://myvillagegreen.com/products/ferritin
PRIME PubMed | Iron requirement in normal pregnancy as assessed by serum ferritin, serum transferrin saturation and erythrocyte...PRIME PubMed | Iron requirement in normal pregnancy as assessed by serum ferritin, serum transferrin saturation and erythrocyte...
Iron requirement in normal pregnancy as assessed by serum ferritin, serum transferrin saturation and erythrocyte protoporphyrin ... Serum ferritin and iron status in mothers and newborn infants.. *[Concentration of ferritin, transferrin and iron as a markers ... Serum ferritin was the most sensitive and specific test of iron deficiency. A practical procedure to detect iron deficiency and ... Serum ferritin was the most sensitive and specific test of iron deficiency. A practical procedure to detect iron deficiency and ...
https://www.unboundmedicine.com/medline/citation/6824608/Iron_requirement_in_normal_pregnancy_as_assessed_by_serum_ferritin_serum_transferrin_saturation_and_erythrocyte_protoporphyrin_determinations_
Canine Ferritin Light Polypeptide ELISA kit, AMS.E08F0137 | AMSBIOCanine Ferritin Light Polypeptide ELISA kit, AMS.E08F0137 | AMSBIO
This ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
https://www.amsbio.com/canine-ferritin-light-polypeptide-elisa-kit-amse08f0137
Protective immunity induced by the ferritin DNA vaccine of Schistosoma japonicum in miceProtective immunity induced by the ferritin DNA vaccine of Schistosoma japonicum in mice
Studies on protective immunity effects of vaccine of co-immunization with recombinant ferritin protein vaccine and epitope ... Schistosoma japonicum recombinant ferritin: expression, purification and its protective immunity against Schistosoma japonicum ... Protective immunity against Schistosoma japonicum infection induced by Sj ferritin in mice. Chinese Journal of Schistosomiasis ... Protective immunity induced by the ferritin DNA vaccine of Schistosoma japonicum in mice. Protective immunity induced by the ...
https://eurekamag.com/research/033/005/033005712.php
CLONORCHIS SINENSIS: MOLECULAR CLONING, ENZYMATIC ACTIVITY, AND LOCALIZATION OF YOLK FERRITIN | Journal of ParasitologyCLONORCHIS SINENSIS: MOLECULAR CLONING, ENZYMATIC ACTIVITY, AND LOCALIZATION OF YOLK FERRITIN | Journal of Parasitology
CLONORCHIS SINENSIS: MOLECULAR CLONING, ENZYMATIC ACTIVITY, AND LOCALIZATION OF YOLK FERRITIN Yi Tang; Yi Tang ... Ferritin is an intracellular protein that is involved in iron metabolism. A cDNA clone of Clonorchis sinensis (CsFtn), 565 bp ... Phylogenetic tree analysis showed that CsFtn clustered with the ferritins of other flukes. Recombinant CsFtn protein was ... Based on these results, CsFtn cDNA is considered to encode a C. sinensis yolk ferritin. ...
https://meridian.allenpress.com/journal-of-parasitology/article-abstract/92/6/1275/3982/CLONORCHIS-SINENSIS-MOLECULAR-CLONING-ENZYMATIC?searchresult=1
Medical Science Monitor | Increased Serum Levels of Hepcidin and Ferritin Are Associated with Severity of COVID-19 - Article...Medical Science Monitor | Increased Serum Levels of Hepcidin and Ferritin Are Associated with Severity of COVID-19 - Article...
Hepcidin and serum ferritin tandem testing predicted COVID-19 severity with 94.6% specificity, while hepcidin and serum ... RESULTS:Patients diagnosed with severe COVID-19 had higher hepcidin and serum ferritin levels than in other groups (p,0.001). A ... Logistic regression analysis showed hepcidin and serum ferritin independently contributed to the severity of COVID-19. ... ferritin parallel testing had a sensitivity of 95.7%. CONCLUSIONS:Iron homeostasis had a robust association with the occurrence ...
https://medscimonit.com/abstract/full/idArt/926178
Lipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance | eLifeLipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance | eLife
... ferritin is responsible for the cytoplasmic iron storage and the maintenance of the redox homeostasis. Ferritin is a protein ... Ferritin heavy chain (FTH1) affects LD accumulation and cell radio-response. One of the main cellular ROS sources is the Fenton ... 2011) H ferritin gene silencing in a human metastatic melanoma cell line: A proteomic analysis Journal of Proteome Research 10: ... 2019) Prognostic Value of Ferritin-to-Hemoglobin Ratio in Patients with Advanced Non-Small-Cell Lung Cancer Journal of Cancer ...
https://elifesciences.org/articles/72943
Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons - Aalborg...Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons - Aalborg...
Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons. / Thomsen, ... Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons. In: ... Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons. Neurobiology ... title = "Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons", ...
https://vbn.aau.dk/en/publications/neurodegeneration-with-inflammation-is-accompanied-by-accumulatio
Ferritin levels and risk of metabolic syndrome: meta-analysis of observational studies | BMC Public Health | Full TextFerritin levels and risk of metabolic syndrome: meta-analysis of observational studies | BMC Public Health | Full Text
The pooled odds ratio (OR) for the metabolic syndrome comparing the highest and lowest category of ferritin levels was 1.73 (95 ... The meta-analysis suggests that increased ferritin levels are independently and positively associated with the presence of the ... Elevated ferritin levels have been associated with single cardiovascular risk factors but the relationship to the presence of ... systematic review and meta-analysis of published observational studies was to estimate the association between serum ferritin ...
https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-14-483/metrics
Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype<...
Chiou, B., Neely, E. B., Mcdevitt, D. S., Simpson, I. A., & Connor, J. R. (2020). Transferrin and H-ferritin involvement in ... Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype. ... Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development : impact of sex and genotype. In ... Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development : impact of sex and genotype. / ...
https://pennstate.pure.elsevier.com/en/publications/transferrin-and-h-ferritin-involvement-in-brain-iron-acquisition-
Initial study of anaemia profile for primary care centres with automated laboratory algorithms reduces the demand for ferritin,...Initial study of anaemia profile for primary care centres with automated laboratory algorithms reduces the demand for ferritin,...
Initial study of anaemia profile for primary care centres with automated laboratory algorithms reduces the demand for ferritin ... Initial study of anaemia profile for primary care centres with automated laboratory algorithms reduces the demand for ferritin ...
https://jcp.bmj.com/content/75/2/94.responses
Abstract B57: Premenopausal plasma ferritin levels, HFE polymorphisms, and risk of breast cancer in the Nurses Health Study II...Abstract B57: Premenopausal plasma ferritin levels, HFE polymorphisms, and risk of breast cancer in the Nurses' Health Study II...
Conclusions: Ferritin levels and HFE SNPs were not associated with breast cancer risk in this population. Components of red ... Among controls, ferritin levels were nominally associated with SNPs rs9366637 (P-value for trend: 0.04), rs6918586 (P-value for ... Premenopausal plasma ferritin levels, HFE polymorphisms, and risk of breast cancer in the Nurses Health Study II. [abstract]. ... Abstract B57: Premenopausal plasma ferritin levels, HFE polymorphisms, and risk of breast cancer in the Nurses Health Study II ...
https://aacrjournals.org/cancerpreventionresearch/article/6/11_Supplement/B57/30883/Abstract-B57-Premenopausal-plasma-ferritin-levels
Anti-h Ferritin 8803 SPRN-5Anti-h Ferritin 8803 SPRN-5
Human ferritin (liver) 167 %, Human ferritin (placenta) 201 %, Human ferritin (heart) < 1.4 %. ... Youre reviewing:Anti-h Ferritin 8803 SPRN-5. Your Rating. 1 star 2 stars 3 stars 4 stars 5 stars ...
https://www.medixbiochemica.com/anti-h-ferritin-100111.html
Serum ferritin levelProteinTransferrin saturation and serum ferritinConcentrationsHigh serum ferritinPlasma ferritin levelsLevelsAntibodyHemoglobinInvolved in iron metabolismIonsLiverSubunitApoferritinProteinsConcentrationHemochromatosisInflammationMicrogliaHomologousGenesLevelInflammatoryLipidAssay1984SubunitsProtoporphyrinFTH1HemosiderinFerrihydriteHemodialysisBloodVaccineHollowIron-deficiParticlesSynthesisDiagnosisStorageTestSpleenUnlikeHuman
Serum ferritin level3
  • The amount of ferritin in the blood (serum ferritin level) is directly related to the amount of iron stored in your body. (medlineplus.gov)
  • A high serum ferritin level is also an indication for liver biopsy. (medscape.com)
  • There was significant positive correlation between fasting and residual volumes and age, weight and height, and between fasting volume and body mass index and serum ferritin level. (who.int)
Protein25
  • Ferritin is a protein inside your cells that stores iron. (medlineplus.gov)
  • Ferritin is the cellular storage protein for iron. (medscape.com)
  • Ferritin in lysosomes is converted into hemosiderin upon partial degradation of its protein shell by lysosomal enzymes. (medscape.com)
  • Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion. (wikipedia.org)
  • Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. (wikipedia.org)
  • Ferritin is a globular protein complex consisting of 24 protein subunits forming a hollow nanocage with multiple metal-protein interactions. (wikipedia.org)
  • Ferritin is a hollow globular protein of mass 474 kDa and comprising 24 subunits. (wikipedia.org)
  • A human mitochondrial ferritin , MtF, was found to express as a pro-protein . (wikipedia.org)
  • [13] When a mitochondrion takes it up, it processes it into a mature protein similar to the ferritins found in the cytoplasm , which it assembles to form functional ferritin shells. (wikipedia.org)
  • [15] The function and structure of the expressed ferritin protein varies in different cell types. (wikipedia.org)
  • The ferritin nanocage is an endogenous protein that exists in almost all mammals. (nature.com)
  • Although there are no currently approved drugs based on ferritin, this multifunctional protein scaffold shows immense potential in drug development in diverse categories, and ferritin-based drugs have recently entered phase I clinical trials. (nature.com)
  • This golden shortlist of recent developments will be of immediate benefit and interest to researchers studying ferritin and other protein-based biotherapeutics. (nature.com)
  • Human H ferritin (HuHF) forms an assembly comprising 24 copies of a four-helix bundle protein. (upenn.edu)
  • Ferritin is the major iron storage protein in the body and provides the most bioavailable form of iron. (myvillagegreen.com)
  • Ferritin is an intracellular protein that is involved in iron metabolism. (allenpress.com)
  • Moreover, we introduce H-ferritin as a key protein in brain iron transport during development and identify a sex and genotype effect demonstrating female mutant mice take up more iron by transferrin, whereas male mutant mice take up more iron from H-ferritin at PND22. (elsevier.com)
  • HHCS arises from various point mutations or deletions within a protein binding sequence in the 5′-UTR of the L-ferritin mRNA that results in increased efficiency of L-ferritin translation. (elsevier.com)
  • Each ferritin molecule consists of ferric iron in a hollow protein shell ( APOFERRITINS ) made of 24 subunits of various sequences depending on the species and tissue types. (bvsalud.org)
  • Saipen et al dehydrogenase (LDH), erythrocyte sedimentation rate CoV-2) pneumonia and minimal pleural effusion on the (ESR), ferritin, C-reactive protein (CRP), aspartate ami- right. (who.int)
  • Increased free iron in the cytosol causes neurons to produce additional ferritin heavy chain, a protein involved in iron storage that can also reduce neuronal connectivity by inhibiting a homeostatic process. (sfn.org)
  • In response, cortical neurons produce additional ferritin heavy chain, which is a protein involved in iron storage that also contributes to dendritic spine deficits by inhibiting the homeostatic chemokine receptor CXCR4. (sfn.org)
  • Previously, we showed that µ-opioid compounds like morphine increased the levels of an iron storage protein called ferritin heavy chain in cortical neurons, which was required for morphine to reduce neuronal connectivity. (sfn.org)
  • From previous research, we knew that 24-hour exposure to morphine increased ferritin heavy chain levels by activating the µ-opioid receptor, which is a protein that transmits opioid signals into cells. (sfn.org)
  • Interestingly, this µ-opioid receptor G-protein signal only increased ferritin heavy chain protein levels in the cytoplasm and did not change the amount of its messenger RNA. (sfn.org)
Transferrin saturation and serum ferritin1
  • The American College of Physicians found insufficient evidence to recommend for or against the use of transferrin saturation and serum ferritin levels to help identify the early stages of hereditary hemochromatosis. (medscape.com)
Concentrations5
  • It is present in small concentrations in blood, and the serum ferritin concentration normally correlates well with total-body iron stores, making its measurement important in the diagnosis of disorders of iron metabolism. (medscape.com)
  • Ferritin is present in small concentrations in blood. (medscape.com)
  • Cellular uptake of human H-ferritin loaded with 50 or 350 iron ions results in significant cytotoxicity on HeLa cells at submicromolar concentrations. (elsevier.com)
  • This guideline provides global, evidence-informed recommendations on the use of indicators for assessing a population's iron status and application of the use of ferritin concentrations for monitoring and evaluating iron interventions. (bvsalud.org)
  • Elevated concentrations of Ferritin and Homocysteine (HcY) are also associated with chronic inflammation much elevated risks of heart attack and stroke. (healthfully.net)
High serum ferritin1
  • Until recently, the only genetic disorder with elevated serum ferritin levels known in Western countries was hereditary HLA-related HFE-related genetic haemochromatosis in Caucasians (HFE, OMIM 235200), and a high serum ferritin in apparently healthy persons was considered suggestive of this disease. (elsevier.com)
Plasma ferritin levels1
  • however, plasma ferritin levels are markedly increased in persons with excess iron. (medscape.com)
Levels18
  • A lower-than-normal level of ferritin occurs if you have anemia caused by low iron levels in the body. (medlineplus.gov)
  • Serum ferritin levels can be measured with a sensitive and specific immunoassay, serving as an index of body iron stores. (medscape.com)
  • This study evaluated the effectiveness of iron supplementation and nutrition education on improving the levels of haemoglobin and ferritin, and decreasing oxidative stress among iron-deficient female adolescents in Gaza, Palestine. (who.int)
  • The levels of haemoglobin, ferritin and malonyl dialdehyde were measured at baseline, after 3 months (at which point the intervention was stopped), and then 3 months later. (who.int)
  • In Group A, haemoglobin, ferritin and malonyl dialdehyde levels decreased after 3 months of stopping the intervention. (who.int)
  • Can low ferritin levels explain breathlessness? (fetcheveryone.com)
  • Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for ferritin levels by conditional logistic regression and for HFE SNPs by unconditional logistic regression. (aacrjournals.org)
  • Results: We did not observe a significant association between ferritin levels and breast cancer (top vs. bottom quartile multivariate OR: 1.05, 95% CI: 0.77-1.45, P-value for trend: 0.77). (aacrjournals.org)
  • Among controls, ferritin levels were nominally associated with SNPs rs9366637 (P-value for trend: 0.04), rs6918586 (P-value for trend: 0.06) and rs13161 (P-value for trend: 0.07), but results did not remain significant after adjusting for multiple testing. (aacrjournals.org)
  • Conclusions: Ferritin levels and HFE SNPs were not associated with breast cancer risk in this population. (aacrjournals.org)
  • The phosphorus levels were close to the limit of detection, giving approximate mean values of P:Fe of 1:44 for the P. laticostata ferritin and 1:36 for the A. hirtosa ferritin. (edu.au)
  • These levels of phosphate are significantly less than those for the crystalline cores of mammalian ferritins and considerably less than those for the noncrystalline core of bacterioferritins. (edu.au)
  • Elevated serum ferritin levels, in the absence of inflammation and liver disease, are currently taken to indicate increased iron stores and require further investigation to determine the site of iron overload. (elsevier.com)
  • It is or hypofibrinogenemia, and elevated associated with severe cytopenias due to ferritin levels are present1. (bvsalud.org)
  • This new study showed that morphine released iron stored in intracellular compartments called endolysosomes, and that this pool of iron was required for morphine to increase ferritin heavy chain levels and reduce the connectivity of cortical neurons. (sfn.org)
  • When morphine increased ferritin heavy chain levels, we also observed a reduction of specific types of dendritic spines that are thought to underlie short-term (learning) and long-term (memory) processes. (sfn.org)
  • Furthermore, morphine-treated rats showed increased neuronal ferritin heavy chain levels and a reduction of the same dendritic spine types in the medial prefrontal cortex, a critically important brain area for learning and memory processing. (sfn.org)
  • The biomarker checked for your iron levels is usually serum ferritin, which is widely established in clinical practice, with low ferritin levels being indicative of iron deficiency, and elevated ferritin levels may be pointing to an iron overload. (bloomdiagnostics.com)
Antibody1
  • The 1st incubation uses 10 uL of sample, a ferritin-specific antibody and a labeled ferritin-specific antibody to form a sandwich complex. (cdc.gov)
Hemoglobin6
  • Research Design and Methods: We performed a retrospective analysis of glycemia outcomes after Roux-en Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) in individuals with elevated hemoglobin A1c (HbA1c) as a function of serum ferritin before and after surgery, using two large and independent electronic health databases from the Carolinas Collaborative and University of Michigan. (diabetesjournals.org)
  • Changes in hemoglobin were also related to preoperative ferritin. (diabetesjournals.org)
  • This is one of the most accurate indicators for determining iron deficiency, ferritin is tested in the presence of a decrease in hemoglobin. (rezus.lt)
  • 2014 ASH President Linda J. Burns, MD, of the University of Minnesota, offers her thoughts on abstract 53, "ACE-536 Increases Hemoglobin and Decreases Transfusion Burden and Serum Ferritin in Adults W. (ascopost.com)
  • Implementing Reticulocyte Hemoglobin Into Hematology Algorithms Might reticulocyte hemoglobin, a potentially more clinically stable analyte than ferritin, be useful in screening for iron deficiency and iron-deficiency anemia? (medscape.com)
  • hemoglobin and ferritin . (wikipedia.org)
Involved in iron metabolism1
  • Among all molecules involved in iron metabolism, ferritin is responsible for the cytoplasmic iron storage and the maintenance of the redox homeostasis. (elifesciences.org)
Ions3
  • Inside the ferritin shell, iron ions form crystallites together with phosphate and hydroxide ions. (wikipedia.org)
  • Each ferritin complex can store about 4500 iron (Fe 3+ ) ions. (wikipedia.org)
  • We propose here that the different cytotoxicity of the two ferritin cages originates from the presence in H-ferritin of a pool of non-biomineralized iron ions bound at the ferroxidase catalytic sites of H-ferritin subunits. (elsevier.com)
Liver4
  • Rat liver siderosome ferritin. (medscape.com)
  • Ferritin concentration can rise due to inflammatory processes, liver metabolism disorder or oncological diseases. (rezus.lt)
  • I: Purification and partial characterization of liver and spleen ferritins. (bvsalud.org)
  • II: A comparison of heart and pancreas ferritins with those of liver and spleen. (bvsalud.org)
Subunit2
  • In the pearl oyster Pinctada fucata , an additional subunit resembling Lymnaea soma ferritin is associated with shell formation. (wikipedia.org)
  • X-ray crystal structure of a designed human H ferritin and a single 4-helix bundle subunit indicating computationally designed mutations to the exterior (red) and interior (yellow) surfaces. (upenn.edu)
Apoferritin1
  • [6] Ferritin that is not combined with iron is called apoferritin . (wikipedia.org)
Proteins2
  • Iron uptake was assessed using 59 Fe bound to either transferrin or H-ferritin as the iron carrier proteins. (elsevier.com)
  • Here, we found that a specific type of µ-opioid receptor signal through G-proteins led to ferritin heavy chain production. (sfn.org)
Concentration2
  • The concentration of ferritin in the blood shows the iron reserves in the body in the most complete way. (rezus.lt)
  • A large body of evidence indicates that the level of serum ferritin parallels the concentration of storage iron within the body, regardless of the cell type in which it is stored. (elsevier.com)
Hemochromatosis1
  • Methods: We conducted a case-control study nested within the NHSII examining prediagnostic plasma ferritin (n=795 cases, 795 controls), 15 hemochromatosis gene ( HFE ) SNPs (n=772 cases, 1,368 controls), and breast cancer risk. (aacrjournals.org)
Inflammation3
  • Ferritin is an acute-phase reactant that coordinates cellular defense against oxidative stress and inflammation along with transferrin and its receptor. (medscape.com)
  • The blood ferritin level serves as an indicator of the amount of iron stored in the body, and it can become elevated due to the presence of conditions featuring significant inflammation. (medicinenet.com)
  • Your ferritin and iron saturation can go very high even though your iron is normal (or low) due to inflammation. (healingwell.com)
Microglia1
  • However, there was a temporal increase in the number of ferritin positive microglia. (nus.edu.sg)
Homologous1
  • CsFtn polypeptide appeared homologous to the ferritin of trematodes with high sequential identity. (allenpress.com)
Genes4
  • Ferritin genes are highly conserved between species. (wikipedia.org)
  • All vertebrate ferritin genes have three introns and four exons . (wikipedia.org)
  • Examples of drugs and agents loaded onto ferritin include chemotherapeutic agents, genes, fluorescent molecules, and various peptides that have been displayed on their surface. (nature.com)
  • Cazzola, M 2005, ' Role of ferritin and ferroportin genes in unexplained hyperferritinaemia ', Best Practice and Research: Clinical Haematology , vol. 18, no. 2 SPEC. (elsevier.com)
Level6
  • The ferritin blood test measures the level of ferritin in the blood. (medlineplus.gov)
  • The lower the ferritin level, even within the "normal" range, the more likely it is that the person does not have enough iron. (medlineplus.gov)
  • [ 71 ] These abnormalities comprise an increased ferritin level, which is sometimes accompanied with elevated transferrin saturation. (medscape.com)
  • Ferritin level increases with age, and the level is higher in men than women. (medscape.com)
  • To gain more under standing in these areas, the present study investigated the time course of dopaminergic cell death and of changes in the level of iron, ferritin and transferrin. (nus.edu.sg)
  • The Bloom Ferritin Test can be used to reflect your body's iron stores and check if your ferritin is at a low or high level, or within normal range. (bloomdiagnostics.com)
Inflammatory1
  • So your high ferritin might be a false reading due to an inflammatory response. (healingwell.com)
Lipid2
  • RESULTS: Low molecular weight (LMW) chelators bound iron, a fraction of BAI in the cells released from coals, ferritin, and lipid peroxidation were significantly higher in cells treated with various coals than in control cells, with an increasing order of UT (cdc.gov)
  • Our results indicate that BAI in the coals of WV and UT is the main metal species in inducing ferritin and lipid peroxidation. (cdc.gov)
Assay1
  • Ferritin Assay Laboratories manufactures the ferritin lab results reagents distributed by Genprice. (ifn-a.com)
19841
  • Proceeding of Ferritin Society of Okayama , 1984, p. 88-90. (elsevier.com)
Subunits1
  • Moreover, the large surface-to-volume ratio and the disassembly/reassembly behavior of the 24 monomer subunits into a sphere allow diverse modifications by chemical and genetic methods on the surface and inner cage of ferritin. (nature.com)
Protoporphyrin1
  • When iron was not given, 15 out of 23 women had exhausted iron stores and iron deficiency at term, as judged from low serum ferritin, low serum transferrin saturation and high erythrocyte protoporphyrin values. (unboundmedicine.com)
FTH11
  • Moreover, we observed that LD content was tightly connected with the iron metabolism and in particular with the presence of the ferritin heavy chain (FTH1). (elifesciences.org)
Hemosiderin3
  • Iron is stored either as hemosiderin or ferritin. (medscape.com)
  • Ferritin is water-soluble, while hemosiderin is water-insoluble. (medscape.com)
  • [4] Aggregated ferritin transforms into a toxic form of iron called hemosiderin . (wikipedia.org)
Ferrihydrite1
  • Diffuse lines in the electron diffraction patterns of the ferritin cores indicated the presence of ferrihydrite (5Fe2-O3·9H2O) of limited crystallinity. (edu.au)
Hemodialysis1
  • IDA with hemodialysis-dependent CKD: serum ferritin less than or equal to 200 ng/mL and TSAT less than or equal to 20 percent or. (clubmentalhealthtalk.com)
Blood2
  • A ferritin test indirectly measures the amount of iron in your blood. (medlineplus.gov)
  • In addition to uric acid monitoring, there are other blood tests such as ferritin which might give extra clues. (goutpal.net)
Vaccine1
  • A study was conducted to evaluate the protective immunity induced by a DNA vaccine co-expressing granulocyte macrophage colony stimulating factor (GMCSF) and Schistosoma japonicum ferritin (SjFer) in mice. (eurekamag.com)
Hollow1
  • The hollow spherical core of ferritin allows the loading of various cargo. (nature.com)
Iron-defici1
  • hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia . (wikipedia.org)
Particles2
  • Ferritin has excellent biosafety profiles, and the nanosized particles exhibit rapid dispersion and controlled/sustained release pharmacokinetics. (nature.com)
  • Phagocytic activity of iron colloid particles and ferritin synthesis in macrophages. (elsevier.com)
Synthesis1
  • Koorts AM, Viljoen M. Ferritin and ferritin isoforms I: Structure-function relationships, synthesis, degradation and secretion. (medscape.com)
Diagnosis1
  • serum ferritin is used to confirm the diagnosis of iron excess. (medscape.com)
Storage1
  • Approximately 25% of the iron in a normal adult is present in a storage form (2), with the most common form being ferritin (accounting for about 2/3 of storage iron). (genetrackus.com)
Test6
  • Serum ferritin was the most sensitive and specific test of iron deficiency. (unboundmedicine.com)
  • A ferritin test may be ordered to evaluate the body's current store of iron and, in conjunction with other tests, to evaluate the severity of anemia or iron overload. (clevelandheartlab.com)
  • The ferritin test may also be used to monitor individuals diagnosed with iron overload. (clevelandheartlab.com)
  • The Ferritin Lab Results reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (ifn-a.com)
  • H. pylori infection was determined by urea breath test and iron deficiency using serum ferritin. (cdc.gov)
  • If you would like to know more about the Bloom Ferritin Test, you can read more about it here . (bloomdiagnostics.com)
Spleen1
  • Ecological Formulas' Ferritin Bioavailable Iron Capsules contain a powerful formula that delivers 5 milligrams of ferritin naturally derived from bovine spleen (molecular weight 445,000). (myvillagegreen.com)
Unlike2
  • Unlike other human ferritins, it appears to have no introns in its genetic code. (wikipedia.org)
  • Unlike many other iron supplements‚ Ferritin Bioavailable Iron doesn't cause negative side effects‚ such as nausea and GI tract upset that are common to ferrous sulphate and other iron salts. (myvillagegreen.com)
Human1
  • [11] In E. coli , a 20% similarity to human H-ferritin is observed. (wikipedia.org)