Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation.
An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.
Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.
Process of administering an anesthetic through injection directly into the bloodstream.
A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Pain during the period after surgery.
A widely used local anesthetic agent.
The application of suitable drug dosage forms to the skin for either local or systemic effects.
Drugs administered before an anesthetic to decrease a patient's anxiety and control the effects of that anesthetic.
The use of two or more chemicals simultaneously or sequentially to induce anesthesia. The drugs need not be in the same dosage form.
The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS.
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).
The period of emergence from general anesthesia, where different elements of consciousness return at different rates.
A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
Acute pain that comes on rapidly despite the use of pain medication.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)
Procedure in which an anesthetic is injected into the epidural space.
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
A variety of anesthetic methods such as EPIDURAL ANESTHESIA used to control the pain of childbirth.
A group of compounds that contain the general formula R-OCH3.
A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
Methods of PAIN relief that may be used with or in place of ANALGESICS.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
A drug-induced depression of consciousness during which patients respond purposefully to verbal commands, either alone or accompanied by light tactile stimulation. No interventions are required to maintain a patent airway. (From: American Society of Anesthesiologists Practice Guidelines)
Introduction of therapeutic agents into the spinal region using a needle and syringe.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A medicated adhesive patch placed on the skin to deliver a specific dose of medication into the bloodstream.
Agents inhibiting the effect of narcotics on the central nervous system.
Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.
Injections made into a vein for therapeutic or experimental purposes.
Extraction of the FETUS by means of abdominal HYSTEROTOMY.
Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.
Emesis and queasiness occurring after anesthesia.
An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.
Procedure in which an anesthetic is injected directly into the spinal cord.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.
A semisynthetic derivative of CODEINE.
A disorder in which the adductor muscles of the VOCAL CORDS exhibit increased activity leading to laryngeal spasm. Laryngismus causes closure of the VOCAL FOLDS and airflow obstruction during inspiration.
A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.
Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.
A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound.
A family of hexahydropyridines.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors.
Surgical incision into the chest wall.
An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)
Drug-induced depression of consciousness during which patients cannot be easily aroused but respond purposely following repeated painful stimulation. The ability to independently maintain ventilatory function may be impaired. (From: American Society of Anesthesiologists Practice Guidelines)
Operative procedures performed on the SKIN.
One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
Intraoral OSTEOTOMY of the lower jaw usually performed in order to correct MALOCCLUSION.
An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
A transient absence of spontaneous respiration.
Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.
An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)
A form of analgesia accompanied by general quiescence and psychic indifference to environmental stimuli, without loss of consciousness, and produced by the combined administration of a major tranquilizer (neuroleptic) and a narcotic.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE.
Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.
The period during a surgical operation.
Androstanes and androstane derivatives which are substituted in any position with one or more hydroxyl groups.
A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.
An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
Accidental or deliberate use of a medication or street drug in excess of normal dosage.
Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.
A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This condition is associated with unstable depolarization of axonal membranes, primarily in the peripheral nervous system. Tetany usually results from HYPOCALCEMIA or reduced serum levels of MAGNESIUM that may be associated with HYPERVENTILATION; HYPOPARATHYROIDISM; RICKETS; UREMIA; or other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1490)
A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.
A range of methods used to reduce pain and anxiety during dental procedures.
A type of oropharyngeal airway that provides an alternative to endotracheal intubation and standard mask anesthesia in certain patients. It is introduced into the hypopharynx to form a seal around the larynx thus permitting spontaneous or positive pressure ventilation without penetration of the larynx or esophagus. It is used in place of a facemask in routine anesthesia. The advantages over standard mask anesthesia are better airway control, minimal anesthetic gas leakage, a secure airway during patient transport to the recovery area, and minimal postoperative problems.
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often described as an inability to resist the urge to move.
Any operation on the cranium or incision into the cranium. (Dorland, 28th ed)
A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release.
The injection of drugs, most often analgesics, into the spinal canal without puncturing the dura mater.
Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.
Space between the dura mater and the walls of the vertebral canal.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc.
Sense of awareness of self and of the environment.
A class of opioid receptors recognized by its pharmacological profile. Delta opioid receptors bind endorphins and enkephalins with approximately equal affinity and have less affinity for dynorphins.
A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. It acts on OPIOID RECEPTORS and is an analgesic. Its first four amino acids at the N-terminal are identical to the tetrapeptide sequence of METHIONINE ENKEPHALIN and LEUCINE ENKEPHALIN.
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
A narcotic analgesic proposed for severe pain. It may be habituating.
Epidural anesthesia administered via the sacral canal.
A state due to excess loss of carbon dioxide from the body. (Dorland, 27th ed)
The surgical removal of HEMORRHOIDS.
The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).
Persistent pain that is refractory to some or all forms of treatment.
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A macrolide antibiotic that is similar to ERYTHROMYCIN.
Elements of limited time intervals, contributing to particular results or situations.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Surgical creation of an opening (stoma) in the URINARY BLADDER for drainage.
An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)
A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
Injection of an anesthetic into the nerves to inhibit nerve transmission in a specific part of the body.
Removal of an endotracheal tube from the patient.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Surgery performed on the female genitalia.
The surgical removal of the inner contents of the eye, leaving the sclera intact. It should be differentiated from ORBIT EVISCERATION which removes the entire contents of the orbit, including eyeball, blood vessels, muscles, fat, nerve supply, and periosteum.
Compounds based on benzeneacetamide, that are similar in structure to ACETANILIDES.
Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.
The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
The constant checking on the state or condition of a patient during the course of a surgical operation (e.g., checking of vital signs).
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed)
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Surgical formation of an opening in the ureter for external drainage of the urine; cutaneous route utilizes a ureteral orifice emerging through the skin.
The aperture in the iris through which light passes.
Disorders related or resulting from abuse or mis-use of opioids.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The circulation in a portion of the body of one individual of blood supplied from another individual.
Change of heartbeat induced by pressure on the eyeball, manipulation of extraocular muscles, or pressure upon the tissue remaining in the orbital apex after enucleation.
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
A dental specialty concerned with the diagnosis and surgical treatment of disease, injuries, and defects of the human oral and maxillofacial region.
A developmental anomaly in which the lower sternum is posteriorly dislocated and concavely deformed, resulting in a funnel-shaped thorax.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Drugs that interrupt transmission at the skeletal neuromuscular junction by causing sustained depolarization of the motor end plate. These agents are primarily used as adjuvants in surgical anesthesia to cause skeletal muscle relaxation.
An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.
A method, developed by Dr. Virginia Apgar, to evaluate a newborn's adjustment to extrauterine life. Five items - heart rate, respiratory effort, muscle tone, reflex irritability, and color - are evaluated 60 seconds after birth and again five minutes later on a scale from 0-2, 0 being the lowest, 2 being normal. The five numbers are added for the Apgar score. A score of 0-3 represents severe distress, 4-7 indicates moderate distress, and a score of 7-10 predicts an absence of difficulty in adjusting to extrauterine life.
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
A narcotic analgesic morphinan used as a sedative in veterinary practice.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Amount of stimulation required before the sensation of pain is experienced.
A class of opioid receptors recognized by its pharmacological profile. Kappa opioid receptors bind dynorphins with a higher affinity than endorphins which are themselves preferred to enkephalins.
A class of nerve fibers as defined by their nerve sheath arrangement. The AXONS of the unmyelinated nerve fibers are small in diameter and usually several are surrounded by a single MYELIN SHEATH. They conduct low-velocity impulses, and represent the majority of peripheral sensory and autonomic fibers, but are also found in the BRAIN and SPINAL CORD.
Biological systems as affected by time. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.
Examination, therapy or surgery of the interior of the larynx performed with a specially designed endoscope.
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
The application of medical knowledge to questions of law.
Drugs that selectively bind to and activate alpha adrenergic receptors.
A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
The number of times an organism breathes with the lungs (RESPIRATION) per unit time, usually per minute.
Surgery which could be postponed or not done at all without danger to the patient. Elective surgery includes procedures to correct non-life-threatening medical problems as well as to alleviate conditions causing psychological stress or other potential risk to patients, e.g., cosmetic or contraceptive surgery.
The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
Ventilation of the middle ear in the treatment of secretory (serous) OTITIS MEDIA, usually by placement of tubes or grommets which pierce the TYMPANIC MEMBRANE.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed)
Administration of a soluble dosage form by placement under the tongue.
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Excision of the adenoids. (Dorland, 28th ed)
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
The process of converting analog data such as continually measured voltage to discrete, digital form.
The giving of drugs, chemicals, or other substances by mouth.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Muscles forming the ABDOMINAL WALL including RECTUS ABDOMINIS, external and internal oblique muscles, transversus abdominis, and quadratus abdominis. (from Stedman, 25th ed)
The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Uptake of substances through the SKIN.
The action of a drug in promoting or enhancing the effectiveness of another drug.
Procedures used to treat and correct deformities, diseases, and injuries to the MUSCULOSKELETAL SYSTEM, its articulations, and associated structures.
The period following a surgical operation.
Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.
A noble gas with the atomic symbol Xe, atomic number 54, and atomic weight 131.30. It is found in the earth's atmosphere and has been used as an anesthetic.
Agents that induce various degrees of analgesia; depression of consciousness, circulation, and respiration; relaxation of skeletal muscle; reduction of reflex activity; and amnesia. There are two types of general anesthetics, inhalation and intravenous. With either type, the arterial concentration of drug required to induce anesthesia varies with the condition of the patient, the desired depth of anesthesia, and the concomitant use of other drugs. (From AMA Drug Evaluations Annual, 1994, p.173)
Therapeutic introduction of ions of soluble salts into tissues by means of electric current. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. It has nothing to do with ION EXCHANGE; AIR IONIZATION nor PHONOPHORESIS, none of which requires current.
Adjunctive computer programs in providing drug treatment to patients.
Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It often becomes a REFERRED PAIN.

Molecular modeling of mu opioid receptor and receptor-ligand interaction. (1/1158)

AIM: To construct the 3D structural model of mu opioid receptor (mu OR) and study the interaction between mu OR and fentanyl derivatives. METHODS: The 3D structure of mu OR was modeled using the bacteriorhodopsin (bRh) as a template, in which the alignments of transmembrane (TM) of bRh and mu OR were achieved by scoring the alignment between the amino acid sequence of mu OR and the structure of bRh. The fentanyl derivatives were docked into the 7 helices of mu OR and the binding energies were calculated. RESULTS: (1) The receptor-ligand interaction models were obtained for fentanyl derivatives. (2) In these models, the fundamental binding sites were possibly Asp147 and His297. The negatively charged oxygen of Asp147 and the positively charged ammonium group of ligand formed the potent electrostatic and hydrogen-binding interactions. Whereas the interactions between the positively charged nitrogen of His297 and the carbonyl oxygen of ligand were weak. In addition, there were some pi-pi interactions between the receptor and the ligand. (3) The binding energies of the receptor-ligand complexes had a good correlation with the analgesic activities (-lg ED50) of the fentanyl derivatives. CONCLUSION: This model is helpful for understanding the receptor-ligand interaction and for designing novel mu OR selective ligands.  (+info)

Molecular modeling of interaction between delta opioid receptor and 3-methylfentanylisothiocyanate. (2/1158)

AIM: To construct a 3D structural model of delta opioid receptor (delta OR) and study its interaction with 3-methylfentanylisothiocyanate (SuperFIT). METHODS: Using the bacteriohodopsin as a template, the 3D structure of delta OR was modeled; SuperFIT was docked into its inside. RESULTS: The interaction model between delta OR and (3R, 4S)-SuperFIT was achieved, in which the important binding sites possibly were Asp128, Ser106, Phe104, Tyr308, and Pro315. Asp128 formed the electrostatic and hydrogen-binding interactions with the protonated nitrogen on piperidine of the ligand. Ser106 formed the electrostatic interaction with the N atom of isothiocyano group of the ligand; whereas Phe104, Tyr308, and Pro315 formed the hydrophobic interactions with the S atom of isothiocyano group. In addition, there were some other interactions between delta OR and the ligand. CONCLUSION: The residues Phe104, Tyr308, Pro315, and Ser106 of delta OR are crucial to the delta selectivity of the ligand, which is beneficial for designing novel delta-selective ligand.  (+info)

Interaction models of 3-methylfentanyl derivatives with mu opioid receptors. (3/1158)

AIM: To study the interaction model of 3-methylfentanyl derivatives with mu opioid receptor. METHODS: After a systematic conformational search, a three-dimensional quantitative structure-activity relationship study was carried out with comparative molecular field analysis (CoMFA). RESULTS: 1) The 6 CoMFA models had good predictive values and each model corresponded to the minimum-energy conformations of 13 compounds studied; 2) The important geometric parameters of mu pharmacophore d1 (A), d2 (A), d3 (A), d4 (A), d5 (A), and d6 (A) were 5.2, 5.4, 4.9, 10.6, 10.2, and 5.8 in Model A; 5.2, 6.5, 3.6, 10.6, 11.6, and 5.8 in Model B; 5.2, 4.6, 4.9, 11.6, 9.2, and 6.5 in Model C; 5.2, 5.4, 4.9, 10.5, 10.3, and 5.8 in Model D; 3.6, 5.4, 4.9, 5.7, 7.5, and 5.7 in Model E; 5.2, 4.7, 4.9, 11.2, 9.5, and 6.4 in Model F, respectively. CONCLUSIONS: The several bioactive conformations of fentanyl analogs possibly existed and did not need to be the absolute minimum-energy conformation, each of which was involved in the interaction with mu opioid receptor.  (+info)

Comparison of three solutions of ropivacaine/fentanyl for postoperative patient-controlled epidural analgesia. (4/1158)

BACKGROUND: Ropivacaine, 0.2%, is a new local anesthetic approved for epidural analgesia. The addition of 4 microg/ml fentanyl improves analgesia from epidural ropivacaine. Use of a lower concentration of ropivacaine-fentanyl may further improve analgesia or decrease side effects. METHODS: Thirty patients undergoing lower abdominal surgery were randomized in a double-blinded manner to receive one of three solutions: 0.2% ropivacaine-4 microg fentanyl 0.1% ropivacaine-2 microg fentanyl, or 0.05% ropivacaine-1 microg fentanyl for patient-controlled epidural analgesia after standardized combined epidural and general anesthesia. Patient-controlled epidural analgesia settings and adjustments for the three solutions were standardized to deliver equivalent drug doses. Pain scores (rest, cough, and ambulation), side effects (nausea, pruritus, sedation, motor block, hypotension, and orthostasis), and patient-controlled epidural analgesia consumption were measured for 48 h. RESULTS: All three solutions produced equivalent analgesia. Motor block was significantly more common (30 vs. 0%) and more intense with the 0.2% ropivacaine-4 microg fentanyl solution. Other side effects were equivalent between solutions and mild in severity. A significantly smaller volume of 0.2% ropivacaine-4 microg fentanyl solution was used, whereas the 0.1% ropivacaine-2 microg fentanyl group used a significantly greater amount of ropivacaine and fentanyl. CONCLUSIONS: Lesser concentrations of ropivacaine and fentanyl provide comparable analgesia with less motor block despite the use of similar amounts of ropivacaine and fentanyl. This finding suggests that concentration of local anesthetic solution at low doses is a primary determinant of motor block with patient-controlled epidural analgesia after lower abdominal surgery.  (+info)

Randomised controlled trial of low dose fentanyl infusion in preterm infants with hyaline membrane disease. (5/1158)

AIM: To evaluate the effects of low dose fentanyl infusion analgesia on behavioural and neuroendocrine stress response and short term outcome in premature infants ventilated for hyaline membrane disease. METHODS: Twenty seven ventilated preterm infants were randomly assigned to receive a mean fentanyl infusion of 1.1 (0.08 SE) micrograms/kg/h for 75 (5) hours, and 28 untreated infants were considered a control group. A behavioural sedation score was used to assess the infants' behaviour. Urinary metanephrine and the normetanephrine:creatinine molar ratio were determined at 0, 24, 48 and 72 hours. Outcome data and ventilatory indexes were recorded for each infant. RESULTS: The fentanyl group showed significantly lower behavioural stress scores and O2 desaturations than controls and lower urinary concentrations of metanephrine and normetanephrine at 24, 48, 72 hours. The two groups showed no significant difference in ventilatory variables or short term outcome. CONCLUSIONS: A short course of low dose fentanyl infusion reduces behavioural sedation scores, O2 desaturations and neuroendocrine stress response in preterm ventilated infants.  (+info)

Fentanyl and morphine, but not remifentanil, inhibit acetylcholine release in pontine regions modulating arousal. (6/1158)

BACKGROUND: Opioids inhibit the rapid eye movement (REM) phase of sleep and decrease acetylcholine (ACh) release in medial pontine reticular formation (mPRF) regions contributing to REM sleep generation. It is not known whether opioids decrease ACh release by acting on cholinergic cell bodies or on cholinergic axon terminals. This study used in vivo microdialysis to test the hypothesis that opioids decrease ACh levels at cholinergic neurons in the laterodorsal tegmental nuclei (LDT) and LDT axon terminals in the mPRF. METHODS: Nine male cats were anesthetized with halothane, and ACh levels within the mPRF or LDT were assayed using microdialysis and high-pressure liquid chromatography (HPLC). ACh levels were analyzed in response to dialysis of the mPRF and LDT with Ringer's solution (control), followed by dialysis with Ringer's solution containing morphine sulfate (MSO4) or naloxone. ACh in the mPRF also was measured during either dialysis delivery or intravenous infusion of remifentanil and during dialysis delivery of fentanyl. RESULTS: Compared with dialysis of Ringer's solution, microdialysis with MSO4 decreased ACh by 23% in the mPRF and by 30% in the LDT. This significant decrease in ACh was antagonized by naloxone. MSO4 and fentanyl each caused a dose-dependent decrease in mPRF ACh when delivered by dialysis. Remifentanil delivered by continuous intravenous infusion or by dialysis into the mPRF did not alter mPRF ACh. CONCLUSIONS: Morphine inhibits ACh at the cholinergic cell body region (LDT) and the terminal field in the mPRF. ACh in the mPRF was not altered by remifentanil and was significantly decreased by fentanyl. Thus, MSO4 and fentanyl disrupt cholinergic neurotransmission in the LDT-mPRF network known to modulate REM sleep and cortical electroencephalographic activation. These data are consistent with the possibility that inhibition of pontine cholinergic neurotransmission contributes to arousal state disruption by opioids.  (+info)

Active transport of fentanyl by the blood-brain barrier. (7/1158)

Previous studies have shown that uptake of the lipophilic opioid, fentanyl, by pulmonary endothelial cells occurs by both passive diffusion and carrier-mediated processes. To evaluate if the latter mechanism also exists in brain endothelium, transport of [3H]fentanyl was examined in primary cultured bovine brain microvessel endothelial cell (BBMEC) monolayers. Uptake of fentanyl appears to occur via a carrier-mediated process as uptake of [3H]fentanyl by BBMECs was significantly inhibited in a dose-dependent manner by unlabeled fentanyl. Fentanyl uptake was also significantly inhibited by either 4 degrees C or sodium azide/2-deoxyglucose, suggesting that carrier-mediated uptake of fentanyl was an active process. Fentanyl was also tested to determine whether it might be a substrate of the endogenous blood-brain barrier efflux transport system, P-glycoprotein (P-gp). Release of [3H]fentanyl or rhodamine 123, a known substrate of P-gp, previously loaded in the BBMECs was studied in the presence or absence of either fentanyl or verapamil, a known competitive inhibitor of P-gp. Both fentanyl (10 microM) and verapamil (100 microM) decreased release of rhodamine 123 from BBMECs, indicating that fentanyl is a substrate of P-gp in the BBMECs. This was further supported by the observation that uptake of [3H]fentanyl was significantly increased in Mg2+-free medium, a condition known to reduce P-gp activity. However, release of [3H]fentanyl was significantly increased when incubated with either unlabeled fentanyl or verapamil. These results suggest that the active P-gp-mediated extrusion of fentanyl in these cells is overshadowed by an active inward transport process, mediated by an as yet unidentified transporter. In addition, verapamil was shown to be a substrate of both P-gp and the fentanyl uptake transporter.  (+info)

Comparison of recovery of propofol and methohexital sedation using an infusion pump. (8/1158)

Two sedative anesthetic agents administered by an infusion pump were compared during third molar surgery. Forty American Society of Anesthesiologists (ASA) class I or II volunteers were randomly allocated to two groups. All subjects received supplemental oxygen via a nasal hood, fentanyl (0.0007 mg/kg intravenous [i.v.] bolus), and midazolam (1 mg/2 min) titrated to effect. Patients then received either 0.3 mg/kg of methohexital or 0.5 mg/kg of propofol via an infusion pump. Upon completion of the bolus, a continuous infusion of 0.05 mg/kg/min methohexital or 0.066 mg/kg/min propofol was administered throughout the procedure. Hemo-dynamic and respiratory parameters and psychomotor performance were compared for the two groups and no significant differences were found. The continuous infusion method maintained a steady level of sedation. Patients receiving propofol had a smoother sedation as judged by the surgeon and anesthetist.  (+info)

Postoperative pain is typically managed with pain medication, which may include opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), or other types of medications. The goal of managing postoperative pain is to provide effective pain relief while minimizing the risk of complications such as addiction, constipation, or nausea and vomiting.

In addition to medication, other techniques for managing postoperative pain may include breathing exercises, relaxation techniques, and alternative therapies such as acupuncture or massage. It is important for patients to communicate with their healthcare provider about the severity of their pain and any side effects they experience from medication, in order to provide effective pain management and minimize complications.

Postoperative pain can be categorized into several different types, including:

* Acute pain: This type of pain is intense but short-lived, typically lasting for a few days or weeks after surgery.
* Chronic pain: This type of pain persists for longer than 3 months after surgery and can be more challenging to manage.
* Neuropathic pain: This type of pain is caused by damage to nerves and can be characterized by burning, shooting, or stabbing sensations.
* Visceral pain: This type of pain originates in the internal organs and can be referred to other areas of the body, such as the back or abdomen.

The exact definition of breakthrough pain varies among healthcare providers, but it is generally characterized by the following features:

1. Sudden onset: Breakthrough pain typically begins suddenly, without any warning signs or gradual progression.
2. Severe intensity: The pain is usually intense and can be described as sharp, stabbing, or throbbing.
3. Limited duration: Breakthrough pain episodes are typically short-lived, lasting from a few minutes to a few hours.
4. Unpredictable nature: Breakthrough pain can occur at any time, even when the patient is taking their regular doses of background medication.
5. Impact on daily activities: Breakthrough pain can significantly disrupt daily activities, causing patients to stop what they are doing and seek relief.

Breakthrough pain can be caused by a variety of factors, including changes in the patient's pain condition, side effects of medication, or other medical conditions. It is important for healthcare providers to understand the underlying causes of breakthrough pain and develop an appropriate treatment plan to manage these episodes effectively.

There are several different types of pain, including:

1. Acute pain: This type of pain is sudden and severe, and it usually lasts for a short period of time. It can be caused by injuries, surgery, or other forms of tissue damage.
2. Chronic pain: This type of pain persists over a long period of time, often lasting more than 3 months. It can be caused by conditions such as arthritis, fibromyalgia, or nerve damage.
3. Neuropathic pain: This type of pain results from damage to the nervous system, and it can be characterized by burning, shooting, or stabbing sensations.
4. Visceral pain: This type of pain originates in the internal organs, and it can be difficult to localize.
5. Psychogenic pain: This type of pain is caused by psychological factors such as stress, anxiety, or depression.

The medical field uses a range of methods to assess and manage pain, including:

1. Pain rating scales: These are numerical scales that patients use to rate the intensity of their pain.
2. Pain diaries: These are records that patients keep to track their pain over time.
3. Clinical interviews: Healthcare providers use these to gather information about the patient's pain experience and other relevant symptoms.
4. Physical examination: This can help healthcare providers identify any underlying causes of pain, such as injuries or inflammation.
5. Imaging studies: These can be used to visualize the body and identify any structural abnormalities that may be contributing to the patient's pain.
6. Medications: There are a wide range of medications available to treat pain, including analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), and muscle relaxants.
7. Alternative therapies: These can include acupuncture, massage, and physical therapy.
8. Interventional procedures: These are minimally invasive procedures that can be used to treat pain, such as nerve blocks and spinal cord stimulation.

It is important for healthcare providers to approach pain management with a multi-modal approach, using a combination of these methods to address the physical, emotional, and social aspects of pain. By doing so, they can help improve the patient's quality of life and reduce their suffering.

PONV can be caused by various factors, including:

1. Anesthesia-related factors: The type and dose of anesthesia used, as well as the duration of anesthesia exposure, can contribute to PONV.
2. Surgical factors: The type and duration of surgery, as well as any complications during the procedure, can increase the risk of PONV.
3. Patient-related factors: Factors such as age, gender, body mass index (BMI), smoking status, and medical history can influence the likelihood of PONV.
4. Medication-related factors: Certain medications used during or after surgery, such as opioids and benzodiazepines, can increase the risk of PONV.

PONV can lead to a range of complications, including dehydration, electrolyte imbalances, and aspiration pneumonia. It can also cause significant discomfort, pain, and distress for patients, leading to delayed recovery and increased healthcare costs.

There are several strategies to prevent or manage PONV, including:

1. Anti-nausea medications: Prophylactic medications such as ondansetron, dolasetron, and granisetron can be given before or after surgery to reduce the risk of PONV.
2. Anesthesia techniques: Techniques such as avoiding general anesthesia, using regional anesthesia, and maintaining a stable body temperature can help reduce the risk of PONV.
3. Patient positioning: Positioning patients in a way that minimizes pressure on the stomach and diaphragm can help reduce the risk of PONV.
4. Fluid management: Encouraging patients to drink fluids before and after surgery can help prevent dehydration and electrolyte imbalances.
5. Deep breathing exercises: Encouraging patients to perform deep breathing exercises during the recovery period can help reduce nausea and vomiting.
6. Aromatherapy: Using aromatherapy with essential oils such as lavender and peppermint can help reduce nausea and vomiting.
7. Ginger: Ginger has anti-inflammatory properties and has been shown to reduce nausea and vomiting in some studies.
8. Vitamin B6: Some studies have suggested that taking vitamin B6 before surgery may reduce the risk of PONV.
9. Acupuncture: Acupuncture has been shown to reduce PONV in some studies.
10. Herbal remedies: Some herbal remedies such as peppermint, ginger, and chamomile have anti-nausea properties and may help reduce PONV.

It is important for patients to discuss their individual risk factors with their anesthesiologist before undergoing surgery and to follow any instructions provided by their healthcare provider regarding prevention and management of PONV.

Word origin: [O. Eng. larynx + Gr. , voice.]

Synonyms:

1. Stuttering.
2. Hysterical stammering.
3. Spasmodic dysartria.

Note under Dysarthria: Laryngismus is a form of spasmodic dysarthria, the spasms being more sudden and violent than in the ordinary type.

Source: Stedman's Medical Dictionary (28th ed.) via MedicineNet.com

Terms popularity compared to other word forms of 'laryngismus':

Laryngismus has been less popular than other word forms such as 'laryngitis'.

Reference link: medicine.net/ned/2013/laryngismus-stuttering.htm

There are several possible causes of muscle rigidity, including:

1. Injury: Muscle rigidity can be a result of direct trauma to the muscle, such as a strain or sprain.
2. Infection: Certain infections, such as Lyme disease or endocarditis, can cause muscle rigidity as a symptom.
3. Neurological disorders: Conditions such as multiple sclerosis, Parkinson's disease, and stroke can all cause muscle rigidity due to damage to the nervous system.
4. Medication side effects: Certain medications, such as steroids and certain antidepressants, can cause muscle rigidity as a side effect.
5. Metabolic disorders: Conditions such as hypocalcemia (low calcium levels) and hyperthyroidism can cause muscle rigidity.
6. Autoimmune disorders: Conditions such as polymyositis and dermatomyositis can cause muscle rigidity due to inflammation of the muscles.

Symptoms of muscle rigidity may include:

* Stiffness or inflexibility in the affected muscles
* Pain or tenderness in the affected area
* Limited range of motion in the affected joints
* Muscle spasms or cramps
* Fatigue or weakness

Treatment for muscle rigidity will depend on the underlying cause. In some cases, medication may be prescribed to relax the muscles and improve mobility. Physical therapy and exercise may also be helpful in improving range of motion and strength. In other cases, treatment may involve addressing the underlying condition or disorder that is causing the muscle rigidity.

There are several types of apnea that can occur during sleep, including:

1. Obstructive sleep apnea (OSA): This is the most common type of apnea and occurs when the airway is physically blocked by the tongue or other soft tissue in the throat, causing breathing to stop for short periods.
2. Central sleep apnea (CSA): This type of apnea occurs when the brain fails to send the proper signals to the muscles that control breathing, resulting in a pause in breathing.
3. Mixed sleep apnea (MSA): This type of apnea is a combination of OSA and CSA, where both central and obstructive factors contribute to the pauses in breathing.
4. Hypopneic apnea: This type of apnea is characterized by a decrease in breathing, but not a complete stop.
5. Hypercapnic apnea: This type of apnea is caused by an excessive buildup of carbon dioxide in the blood, which can lead to pauses in breathing.

The symptoms of apnea can vary depending on the type and severity of the condition, but may include:

* Pauses in breathing during sleep
* Waking up with a dry mouth or sore throat
* Morning headaches
* Difficulty concentrating or feeling tired during the day
* High blood pressure
* Heart disease

Treatment options for apnea depend on the underlying cause, but may include:

* Lifestyle changes, such as losing weight, avoiding alcohol and sedatives before bedtime, and sleeping on your side
* Oral appliances or devices that advance the position of the lower jaw and tongue
* Continuous positive airway pressure (CPAP) therapy, which involves wearing a mask during sleep to deliver a constant flow of air pressure into the airways
* Bi-level positive airway pressure (BiPAP) therapy, which involves two levels of air pressure: one for inhalation and another for exhalation
* Surgery to remove excess tissue in the throat or correct physical abnormalities that are contributing to the apnea.

There are several different types of unconsciousness, including:

1. Concussion: A mild form of traumatic brain injury that can cause temporary unconsciousness, confusion, and amnesia.
2. Coma: A more severe form of unconsciousness that can be caused by a head injury, stroke, or other medical condition. Comas can last for days, weeks, or even months.
3. Vegetative state: A condition in which a person is unaware and unresponsive, but still has some reflexes. This can be caused by a traumatic brain injury, stroke, or other medical condition.
4. Persistent vegetative state (PVS): A long-term version of the vegetative state that can last for months or years.
5. Brain death: A permanent form of unconsciousness that is caused by severe damage to the brain.

Unconsciousness can be diagnosed through a variety of medical tests, including:

1. Neurological exam: A doctor will check the patient's reflexes, muscle strength, and sensation to determine the extent of any brain damage.
2. Imaging tests: CT or MRI scans can help doctors identify any structural abnormalities in the brain that may be causing unconsciousness.
3. Electroencephalogram (EEG): A test that measures electrical activity in the brain to determine if there is any abnormal brain wave activity.
4. Blood tests: To rule out other medical conditions that may be causing unconsciousness, such as infections or poisoning.

Treatment for unconsciousness depends on the underlying cause and can range from simple observation to complex surgical procedures. Some common treatments include:

1. Medications: To control seizures, reduce inflammation, or regulate brain activity.
2. Surgery: To relieve pressure on the brain, repair damaged blood vessels, or remove tumors.
3. Rehabilitation: To help the patient regain lost cognitive and motor function.
4. Supportive care: To address any other medical conditions that may be contributing to the unconsciousness, such as infections or respiratory failure.

Supratentorial neoplasms can cause a variety of symptoms, including headaches, seizures, weakness or numbness in the arms or legs, and changes in personality or behavior. They can also cause hydrocephalus, a condition in which fluid accumulates in the brain, leading to increased intracranial pressure and potentially life-threatening complications.

The diagnosis of supratentorial neoplasms typically involves a combination of imaging studies such as CT or MRI scans, and tissue biopsy. Treatment options for supratentorial neoplasms depend on the type and location of the tumor, and may include surgery, radiation therapy, and chemotherapy.

Some common types of supratentorial neoplasms include:

* Gliomas: These are the most common type of primary brain tumor, arising from the supporting cells of the brain called glial cells. Examples of gliomas include astrocytomas, oligodendrogliomas, and glioblastoma multiforme.
* Meningiomas: These are tumors that arise from the meninges, the membranes covering the brain and spinal cord. Meningiomas are usually benign but can occasionally be malignant.
* Acoustic neurinomas: These are slow-growing tumors that develop on the nerve that connects the inner ear to the brain.
* Pineal region tumors: These are tumors that arise in the pineal gland, a small endocrine gland located in the brain. Examples of pineal region tumors include pineal parenchymal tumors and pineal gland-derived tumors.

Overall, supratentorial neoplasms can be challenging to diagnose and treat, and may require a multidisciplinary approach involving neurosurgeons, radiation oncologists, and medical oncologists. Prognosis and treatment options vary depending on the specific type of tumor and its location in the brain.

There are several types of drug overdoses, including:

1. Opioid overdose: This is the most common type of drug overdose and is caused by taking too much of an opioid medication or street drug like heroin.
2. Stimulant overdose: This occurs when someone takes too much of a stimulant drug like cocaine or amphetamines.
3. Depressant overdose: This is caused by taking too much of a depressant drug like alcohol, benzodiazepines, or barbiturates.
4. Hallucinogenic overdose: This happens when someone takes too much of a hallucinogenic drug like LSD or psilocybin mushrooms.

The symptoms of a drug overdose can vary depending on the type of drug taken, but common signs include:

1. Confusion and disorientation
2. Slurred speech and difficulty speaking
3. Dizziness and loss of balance
4. Nausea and vomiting
5. Slow or irregular breathing
6. Seizures or convulsions
7. Cold, clammy skin
8. Blue lips and fingernails
9. Coma or unresponsiveness
10. Death

If you suspect someone has overdosed on drugs, it is essential to seek medical attention immediately. Call emergency services or bring the person to the nearest hospital.

Treatment for drug overdoses usually involves supportive care, such as oxygen therapy, fluids, and medication to manage symptoms. In severe cases, a patient may need to be placed on life support or receive other intensive treatments.

Preventing drug overdoses is crucial, and this can be achieved by avoiding the use of drugs altogether, using drugs only as directed by a medical professional, and having access to naloxone, a medication that can reverse the effects of an opioid overdose.

In conclusion, drug overdoses are a significant public health issue that can have severe consequences, including death. It is important to be aware of the signs and symptoms of drug overdoses and seek medical attention immediately if you suspect someone has overdosed. Additionally, prevention measures such as avoiding drug use and having access to naloxone can help reduce the risk of overdose.

The exact mechanism by which drugs can cause akathisia is not fully understood, but it is believed to involve changes in the levels of certain neurotransmitters (such as dopamine and serotonin) in the brain. These changes can affect the normal functioning of the nervous system, leading to symptoms such as agitation, restlessness, and an excessive desire to move about.

Drug-induced akathisia can occur with a wide range of medications and drugs, including antipsychotic medications, antidepressants, stimulants, and certain illegal substances. It is important for healthcare professionals to be aware of the potential for drug-induced akathisia when prescribing these medications, as it can be a serious side effect that can negatively impact a person's quality of life.

Treatment for drug-induced akathisia typically involves stopping or reducing the medication that is causing the symptoms. In some cases, additional medications may be prescribed to help manage the symptoms and reduce discomfort. It is important for individuals experiencing drug-induced akathisia to work closely with their healthcare provider to find the best course of treatment.

Respiratory alkalosis can occur due to various causes such as hypoventilation (breathing too slowly), hypercapnia (excessive carbon dioxide in the blood), bicarbonate therapy, or drinking excessive amounts of antacids. Symptoms may include vomiting, abdominal pain, headache, and muscle weakness.

Treatment typically involves addressing the underlying cause, such as correcting hypoventilation or removing excess carbon dioxide from the bloodstream. In severe cases, medications or mechanical ventilation may be necessary.

Intractable pain can have a significant impact on an individual's quality of life, affecting their ability to perform daily activities, sleep, and overall well-being. Treatment for intractable pain often involves a combination of medications and alternative therapies such as physical therapy, acupuncture, or cognitive behavioral therapy.

Some common symptoms of intractable pain include:

* Chronic and persistent pain that does not respond to treatment
* Pain that is severe and debilitating
* Pain that affects daily activities and quality of life
* Pain that is burning, shooting, stabbing, or cramping in nature
* Pain that is localized to a specific area of the body or widespread
* Pain that is accompanied by other symptoms such as fatigue, anxiety, or depression.

Intractable pain can be caused by a variety of factors, including:

* Nerve damage or nerve damage from injury or disease
* Inflammation or swelling in the body
* Chronic conditions like arthritis, fibromyalgia, or migraines
* Infections such as shingles or Lyme disease
* Cancer or its treatment
* Neurological disorders such as multiple sclerosis or Parkinson's disease.

Managing intractable pain can be challenging and may involve a multidisciplinary approach, including:

* Medications such as pain relievers, anti-inflammatory drugs, or muscle relaxants
* Alternative therapies such as physical therapy, acupuncture, or cognitive behavioral therapy
* Lifestyle changes such as regular exercise, stress management techniques, and a healthy diet
* Interventional procedures such as nerve blocks or spinal cord stimulation.

It is important to work closely with a healthcare provider to find the most effective treatment plan for managing intractable pain. With the right combination of medications and alternative therapies, many people are able to manage their pain and improve their quality of life.

Some common examples of opioid-related disorders include:

1. Opioid dependence: This is a condition in which an individual becomes physically dependent on opioids and experiences withdrawal symptoms when they stop using the medication.
2. Opioid abuse: This is a condition in which an individual uses opioids for non-medical reasons, such as to get high or to cope with emotional issues.
3. Opioid addiction: This is a chronic condition characterized by compulsive drug-seeking behavior despite negative consequences.
4. Opioid overdose: This occurs when an individual takes too much of an opioid medication and experiences life-threatening symptoms, such as slowed breathing or heart rate.
5. Opioid withdrawal syndrome: This is a group of symptoms that can occur when an individual stops using opioids after a period of heavy use. Symptoms can include anxiety, depression, muscle aches, and insomnia.
6. Opioid-induced hyperalgesia: This is a condition in which the use of opioids leads to increased sensitivity to pain.
7. Opioid-induced constipation: This is a common side effect of opioid use that can lead to a range of other health problems, such as hemorrhoids and urinary tract infections.
8. Opioid-related cognitive impairment: This is a condition in which the use of opioids leads to difficulty with concentration, memory, and decision-making.
9. Opioid-related depression: This is a condition in which the use of opioids leads to feelings of sadness, hopelessness, and a lack of interest in activities that were once enjoyed.
10. Opioid-related anxiety: This is a condition in which the use of opioids leads to feelings of anxiety, nervousness, and fear.

It is important to note that not everyone who uses opioids will experience these side effects, and the severity of the side effects can vary depending on the individual and the specific opioid being used. Additionally, there are many strategies that healthcare providers can use to help manage these side effects, such as adjusting the dose of the medication or switching to a different medication.

It is also important to note that the risks associated with opioids do not outweigh the benefits for everyone. For some individuals, the benefits of using opioids to manage pain and improve quality of life can far outweigh the risks. However, it is important to carefully weigh the potential risks and benefits before starting opioid therapy, and to closely monitor the individual's health and well-being while they are taking these medications.

In summary, opioids can have a range of side effects, both short-term and long-term, that can impact an individual's physical and mental health. It is important to carefully consider the potential risks and benefits before starting opioid therapy, and to closely monitor the individual's health and well-being while they are taking these medications.

Visceral pain can be caused by a variety of factors, including inflammation, infection, injury, or obstruction of the affected organ or structure. Some common examples of visceral pain include:

1. Appendicitis: inflammation of the appendix that can cause severe, localized pain in the lower right abdomen.
2. Endometriosis: a condition in which tissue similar to the lining of the uterus grows outside of the uterus and can cause pain, bleeding, and other symptoms.
3. Kidney stones: small, hard mineral deposits that can form in the kidneys and cause severe pain in the flank or abdomen.
4. Irritable bowel syndrome (IBS): a condition characterized by recurring abdominal pain, bloating, and changes in bowel movements.
5. Ovarian cysts: fluid-filled sacs that can form on the ovaries and cause pelvic pain, bloating, and other symptoms.

Visceral pain can be difficult to diagnose and treat because it can be referred to other areas of the body, such as the back or the abdomen, and can be accompanied by other symptoms like nausea, vomiting, and diarrhea. Imaging tests like CT scans or ultrasound may be used to help identify the source of the pain, and medications like pain relievers, anti-inflammatory drugs, or antibiotics may be prescribed to treat the underlying cause of the pain.

Neoplasm refers to an abnormal growth of cells that can be benign (non-cancerous) or malignant (cancerous). Neoplasms can occur in any part of the body and can affect various organs and tissues. The term "neoplasm" is often used interchangeably with "tumor," but while all tumors are neoplasms, not all neoplasms are tumors.

Types of Neoplasms

There are many different types of neoplasms, including:

1. Carcinomas: These are malignant tumors that arise in the epithelial cells lining organs and glands. Examples include breast cancer, lung cancer, and colon cancer.
2. Sarcomas: These are malignant tumors that arise in connective tissue, such as bone, cartilage, and fat. Examples include osteosarcoma (bone cancer) and soft tissue sarcoma.
3. Lymphomas: These are cancers of the immune system, specifically affecting the lymph nodes and other lymphoid tissues. Examples include Hodgkin lymphoma and non-Hodgkin lymphoma.
4. Leukemias: These are cancers of the blood and bone marrow that affect the white blood cells. Examples include acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL).
5. Melanomas: These are malignant tumors that arise in the pigment-producing cells called melanocytes. Examples include skin melanoma and eye melanoma.

Causes and Risk Factors of Neoplasms

The exact causes of neoplasms are not fully understood, but there are several known risk factors that can increase the likelihood of developing a neoplasm. These include:

1. Genetic predisposition: Some people may be born with genetic mutations that increase their risk of developing certain types of neoplasms.
2. Environmental factors: Exposure to certain environmental toxins, such as radiation and certain chemicals, can increase the risk of developing a neoplasm.
3. Infection: Some neoplasms are caused by viruses or bacteria. For example, human papillomavirus (HPV) is a common cause of cervical cancer.
4. Lifestyle factors: Factors such as smoking, excessive alcohol consumption, and a poor diet can increase the risk of developing certain types of neoplasms.
5. Family history: A person's risk of developing a neoplasm may be higher if they have a family history of the condition.

Signs and Symptoms of Neoplasms

The signs and symptoms of neoplasms can vary depending on the type of cancer and where it is located in the body. Some common signs and symptoms include:

1. Unusual lumps or swelling
2. Pain
3. Fatigue
4. Weight loss
5. Change in bowel or bladder habits
6. Unexplained bleeding
7. Coughing up blood
8. Hoarseness or a persistent cough
9. Changes in appetite or digestion
10. Skin changes, such as a new mole or a change in the size or color of an existing mole.

Diagnosis and Treatment of Neoplasms

The diagnosis of a neoplasm usually involves a combination of physical examination, imaging tests (such as X-rays, CT scans, or MRI scans), and biopsy. A biopsy involves removing a small sample of tissue from the suspected tumor and examining it under a microscope for cancer cells.

The treatment of neoplasms depends on the type, size, location, and stage of the cancer, as well as the patient's overall health. Some common treatments include:

1. Surgery: Removing the tumor and surrounding tissue can be an effective way to treat many types of cancer.
2. Chemotherapy: Using drugs to kill cancer cells can be effective for some types of cancer, especially if the cancer has spread to other parts of the body.
3. Radiation therapy: Using high-energy radiation to kill cancer cells can be effective for some types of cancer, especially if the cancer is located in a specific area of the body.
4. Immunotherapy: Boosting the body's immune system to fight cancer can be an effective treatment for some types of cancer.
5. Targeted therapy: Using drugs or other substances to target specific molecules on cancer cells can be an effective treatment for some types of cancer.

Prevention of Neoplasms

While it is not always possible to prevent neoplasms, there are several steps that can reduce the risk of developing cancer. These include:

1. Avoiding exposure to known carcinogens (such as tobacco smoke and radiation)
2. Maintaining a healthy diet and lifestyle
3. Getting regular exercise
4. Not smoking or using tobacco products
5. Limiting alcohol consumption
6. Getting vaccinated against certain viruses that are associated with cancer (such as human papillomavirus, or HPV)
7. Participating in screening programs for early detection of cancer (such as mammograms for breast cancer and colonoscopies for colon cancer)
8. Avoiding excessive exposure to sunlight and using protective measures such as sunscreen and hats to prevent skin cancer.

It's important to note that not all cancers can be prevented, and some may be caused by factors that are not yet understood or cannot be controlled. However, by taking these steps, individuals can reduce their risk of developing cancer and improve their overall health and well-being.

Hyperalgesia is often seen in people with chronic pain conditions, such as fibromyalgia, and it can also be a side effect of certain medications or medical procedures. Treatment options for hyperalgesia depend on the underlying cause of the condition, but may include pain management techniques, physical therapy, and medication adjustments.

In clinical settings, hyperalgesia is often assessed using a pinprick test or other pain tolerance tests to determine the patient's sensitivity to different types of stimuli. The goal of treatment is to reduce the patient's pain and improve their quality of life.

There are several causes of hypotension, including:

1. Dehydration: Loss of fluids and electrolytes can cause a drop in blood pressure.
2. Blood loss: Losing too much blood can lead to hypotension.
3. Medications: Certain medications, such as diuretics and beta-blockers, can lower blood pressure.
4. Heart conditions: Heart failure, cardiac tamponade, and arrhythmias can all cause hypotension.
5. Endocrine disorders: Hypothyroidism (underactive thyroid) and adrenal insufficiency can cause low blood pressure.
6. Vasodilation: A condition where the blood vessels are dilated, leading to low blood pressure.
7. Sepsis: Severe infection can cause hypotension.

Symptoms of hypotension can include:

1. Dizziness and lightheadedness
2. Fainting or passing out
3. Weakness and fatigue
4. Confusion and disorientation
5. Pale, cool, or clammy skin
6. Fast or weak pulse
7. Shortness of breath
8. Nausea and vomiting

If you suspect that you or someone else is experiencing hypotension, it is important to seek medical attention immediately. Treatment will depend on the underlying cause of the condition, but may include fluids, electrolytes, and medication to raise blood pressure. In severe cases, hospitalization may be necessary.

Hypercapnia is a medical condition where there is an excessive amount of carbon dioxide (CO2) in the bloodstream. This can occur due to various reasons such as:

1. Respiratory failure: When the lungs are unable to remove enough CO2 from the body, leading to an accumulation of CO2 in the bloodstream.
2. Lung disease: Certain lung diseases such as chronic obstructive pulmonary disease (COPD) or pneumonia can cause hypercapnia by reducing the ability of the lungs to exchange gases.
3. Medication use: Certain medications, such as anesthetics and sedatives, can slow down breathing and lead to hypercapnia.

The symptoms of hypercapnia can vary depending on the severity of the condition, but may include:

1. Headaches
2. Dizziness
3. Confusion
4. Shortness of breath
5. Fatigue
6. Sleep disturbances

If left untreated, hypercapnia can lead to more severe complications such as:

1. Respiratory acidosis: When the body produces too much acid, leading to a drop in blood pH.
2. Cardiac arrhythmias: Abnormal heart rhythms can occur due to the increased CO2 levels in the bloodstream.
3. Seizures: In severe cases of hypercapnia, seizures can occur due to the changes in brain chemistry caused by the excessive CO2.

Treatment for hypercapnia typically involves addressing the underlying cause and managing symptoms through respiratory support and other therapies as needed. This may include:

1. Oxygen therapy: Administering oxygen through a mask or nasal tubes to help increase oxygen levels in the bloodstream and reduce CO2 levels.
2. Ventilation assistance: Using a machine to assist with breathing, such as a ventilator, to help remove excess CO2 from the lungs.
3. Carbon dioxide removal: Using a device to remove CO2 from the bloodstream, such as a dialysis machine.
4. Medication management: Adjusting medications that may be contributing to hypercapnia, such as anesthetics or sedatives.
5. Respiratory therapy: Providing breathing exercises and other techniques to help improve lung function and reduce symptoms.

It is important to seek medical attention if you suspect you or someone else may have hypercapnia, as early diagnosis and treatment can help prevent complications and improve outcomes.

The most common substances associated with NAS are opioids, such as heroin and prescription painkillers, as well as other drugs like cocaine and methamphetamine. NAS can also occur in babies born to mothers who drank alcohol during pregnancy.

Symptoms of NAS can include:

1. Tremors or shaking
2. Irritability or fussiness
3. Poor feeding or sucking
4. Sleep disturbances
5. Diarrhea or vomiting
6. Fever
7. Seizures (rare)

In some cases, NAS can be severe and require medical intervention. Treatment for NAS typically involves providing supportive care to the baby, such as hydration and nutrition, as well as medications to manage withdrawal symptoms. In severe cases, babies may need to be admitted to a specialized neonatal unit for intensive care.

Preventing NAS is essential, and it involves avoiding substance use during pregnancy. If a woman is struggling with addiction, she should seek professional help as early in her pregnancy as possible. With appropriate treatment and support, it is possible to reduce the risk of NAS and ensure a healthy pregnancy and birth.

In conclusion, Neonatal Abstinence Syndrome is a condition that affects newborn babies who were exposed to drugs or alcohol in the womb. Symptoms can range from mild to severe and require medical attention. Prevention involves avoiding substance use during pregnancy, and with appropriate treatment and support, it is possible to reduce the risk of NAS and ensure a healthy pregnancy and birth.

Some common examples of obstetric labor complications include:

1. Prolonged labor: When labor lasts for an extended period, it can increase the risk of infection, bleeding, or other complications.
2. Fetal distress: If the baby is not getting enough oxygen, it can lead to fetal distress, which can cause a range of symptoms, including abnormal heart rate and decreased muscle tone.
3. Placental abruption: This occurs when the placenta separates from the uterus, which can cause bleeding, deprive the baby of oxygen, and lead to premature delivery.
4. Cephalopelvic disproportion: When the baby's head or pelvis is larger than the mother's, it can make delivery difficult or impossible, leading to complications such as prolonged labor or a cesarean section.
5. Dystocia: This refers to abnormal or difficult labor, which can be caused by various factors, including fetal size or position, maternal weight, or abnormalities in the pelvis or cervix.
6. Postpartum hemorrhage: Excessive bleeding after delivery can be a life-threatening complication for both mothers and babies.
7. Infection: Bacterial infections, such as endometritis or sepsis, can occur during labor and delivery and can pose serious health risks to both the mother and the baby.
8. Preeclampsia: A pregnancy-related condition characterized by high blood pressure and damage to organs such as the kidneys and liver.
9. Gestational diabetes: A type of diabetes that develops during pregnancy, which can increase the risk of complications for both the mother and the baby.
10. Cholestasis of pregnancy: A condition in which the gallbladder becomes inflamed, leading to abdominal pain and liver dysfunction.

It is important to note that not all large babies will experience these complications, and many can be delivered safely with proper medical care and attention. However, the risk of these complications does increase as the baby's size increases.

In some cases, doctors may recommend delivery by cesarean section (C-section) if they suspect that the baby is too large to pass through the birth canal safely. This decision will be based on a variety of factors, including the mother's health, the baby's size and position, and any other medical conditions or complications that may be present.

Overall, while a big baby can pose some risks during delivery, modern medicine and obstetric care have made it possible to deliver most babies safely, even if they are larger than average. If you have any concerns about your baby's size or your own health during pregnancy, be sure to discuss them with your healthcare provider.

In medical terms, craniocerebral trauma is defined as any injury that affects the skull, brain, or both, as a result of an external force. This can include fractures of the skull, intracranial hemorrhages (bleeding inside the skull), and diffuse axonal injuries (DAI), which are tears in the fibers of the brain.

Craniocerebral trauma can be classified into two main categories: closed head injury and open head injury. Closed head injury occurs when the skull does not fracture, but the brain is still affected by the impact, such as from whiplash or shaking. Open head injury, on the other hand, involves a fracture of the skull, which can cause the brain to be exposed to the outside environment and increase the risk of infection.

Treatment for craniocerebral trauma depends on the severity of the injury and may include observation, medication, surgery, or a combination of these. In severe cases, craniocerebral trauma can lead to long-term cognitive, emotional, and physical impairments, and may require ongoing rehabilitation and support.

Some common examples of intraoperative complications include:

1. Bleeding: Excessive bleeding during surgery can lead to hypovolemia (low blood volume), anemia (low red blood cell count), and even death.
2. Infection: Surgical wounds can become infected, leading to sepsis or bacteremia (bacterial infection of the bloodstream).
3. Nerve damage: Surgery can sometimes result in nerve damage, leading to numbness, weakness, or paralysis.
4. Organ injury: Injury to organs such as the liver, lung, or bowel can occur during surgery, leading to complications such as bleeding, infection, or organ failure.
5. Anesthesia-related complications: Problems with anesthesia can include respiratory or cardiac depression, allergic reactions, or awareness during anesthesia (a rare but potentially devastating complication).
6. Hypotension: Low blood pressure during surgery can lead to inadequate perfusion of vital organs and tissues, resulting in organ damage or death.
7. Thromboembolism: Blood clots can form during surgery and travel to other parts of the body, causing complications such as stroke, pulmonary embolism, or deep vein thrombosis.
8. Postoperative respiratory failure: Respiratory complications can occur after surgery, leading to respiratory failure, pneumonia, or acute respiratory distress syndrome (ARDS).
9. Wound dehiscence: The incision site can separate or come open after surgery, leading to infection, fluid accumulation, or hernia.
10. Seroma: A collection of serous fluid that can develop at the surgical site, which can become infected and cause complications.
11. Nerve damage: Injury to nerves during surgery can result in numbness, weakness, or paralysis, sometimes permanently.
12. Urinary retention or incontinence: Surgery can damage the bladder or urinary sphincter, leading to urinary retention or incontinence.
13. Hematoma: A collection of blood that can develop at the surgical site, which can become infected and cause complications.
14. Pneumonia: Inflammation of the lungs after surgery can be caused by bacteria, viruses, or fungi and can lead to serious complications.
15. Sepsis: A systemic inflammatory response to infection that can occur after surgery, leading to organ dysfunction and death if not treated promptly.

It is important to note that these are potential complications, and not all patients will experience them. Additionally, many of these complications are rare, and the vast majority of surgeries are successful with minimal or no complications. However, it is important for patients to be aware of the potential risks before undergoing surgery so they can make an informed decision about their care.

Early Postmortem Changes:

1. Cessation of metabolic processes: After death, the body's metabolic processes come to a standstill, leading to a decrease in body temperature, cellular respiration, and other physiological functions.
2. Decline in blood pressure: The heart stops pumping blood, causing a rapid decline in blood pressure.
3. Cardiac arrest: The heart stops beating, leading to a lack of oxygen supply to the body's tissues.
4. Brain death: The brain ceases to function, causing a loss of consciousness and reflexes.
5. Rigor mortis: The muscles become stiff and rigid due to the buildup of lactic acid and other metabolic byproducts.
6. Livor mortis: Blood settles in the dependent parts of the body, causing discoloration and swelling.
7. Algor mortis: The body's temperature cools, causing the skin to feel cool to the touch.

Late Postmortem Changes:

1. Decomposition: Bacteria and other microorganisms begin to break down the body's tissues, leading to putrefaction and decay.
2. Autolysis: Enzymes within the body's cells break down cellular components, causing self-digestion and softening of the tissues.
3. Lipid decomposition: Fats and oils in the body undergo oxidation, leading to the formation of offensive odors.
4. Coagulative necrosis: Blood pools in the body's tissues, causing damage to the cells and tissues.
5. Putrefaction: Bacteria in the gut and other parts of the body cause the breakdown of tissues, leading to the formation of gases and fluids.

It is important to note that postmortem changes can significantly impact the interpretation of autopsy findings and the determination of cause of death. Therefore, it is essential to consider these changes when performing an autopsy and interpreting the results.

The term cough is used to describe a wide range of symptoms that can be caused by various conditions affecting the respiratory system. Coughs can be classified as either dry or productive, depending on whether they produce mucus or not. Dry coughs are often described as hacking, barking, or non-productive, while productive coughs are those that bring up mucus or other substances from the lungs or airways.

Causes of Cough:

There are many potential causes of cough, including:

* Upper respiratory tract infections such as the common cold and influenza
* Lower respiratory tract infections such as bronchitis and pneumonia
* Allergies, including hay fever and allergic rhinitis
* Asthma and other chronic lung conditions
* Gastroesophageal reflux disease (GERD), which can cause coughing due to stomach acid flowing back up into the throat
* Environmental factors such as smoke, dust, and pollution
* Medications such as ACE inhibitors and beta blockers.

Symptoms of Cough:

In addition to the characteristic forceful expulsion of air from the lungs, coughs can be accompanied by a range of other symptoms that may include:

* Chest tightness or discomfort
* Shortness of breath or wheezing
* Fatigue and exhaustion
* Headache
* Sore throat or hoarseness
* Coughing up mucus or other substances.

Diagnosis and Treatment of Cough:

The diagnosis and treatment of cough will depend on the underlying cause. In some cases, a cough may be a symptom of a more serious condition that requires medical attention, such as pneumonia or asthma. In other cases, a cough may be caused by a minor infection or allergy that can be treated with over-the-counter medications and self-care measures.

Some common treatments for cough include:

* Cough suppressants such as dextromethorphan or pholcodine to relieve the urge to cough
* Expectorants such as guaifenesin to help loosen and clear mucus from the airways
* Antihistamines to reduce the severity of allergic reactions and help relieve a cough.
* Antibiotics if the cough is caused by a bacterial infection
* Inhalers and nebulizers to deliver medication directly to the lungs.

It is important to note that while cough can be a symptom of a serious condition, it is not always necessary to see a doctor for a cough. However, if you experience any of the following, you should seek medical attention:

* A persistent and severe cough that lasts for more than a few days or weeks
* A cough that worsens at night or with exertion
* Coughing up blood or mucus that is thick and yellow or greenish in color
* Shortness of breath or chest pain
* Fever, chills, or body aches that are severe or persistent.

It is also important to note that while over-the-counter medications can provide relief from symptoms, they may not address the underlying cause of the cough. If you have a persistent or severe cough, it is important to see a doctor to determine the cause and receive proper treatment.

There are several types of poisoning, including:

1. Acute poisoning: This occurs when a person is exposed to a large amount of a poisonous substance over a short period of time. Symptoms can include nausea, vomiting, diarrhea, and difficulty breathing.
2. Chronic poisoning: This occurs when a person is exposed to a small amount of a poisonous substance over a longer period of time. Symptoms can include fatigue, weight loss, and damage to organs such as the liver or kidneys.
3. Occupational poisoning: This occurs when a worker is exposed to a poisonous substance in the course of their work. Examples include exposure to pesticides, lead, and mercury.
4. Environmental poisoning: This occurs when a person is exposed to a poisonous substance in their environment, such as through contaminated water or soil.
5. Food poisoning: This occurs when a person eats food that has been contaminated with a poisonous substance, such as bacteria or viruses. Symptoms can include nausea, vomiting, diarrhea, and stomach cramps.

Treatment for poisoning depends on the type of poison and the severity of the exposure. Some common treatments include activated charcoal to absorb the poison, medications to counteract the effects of the poison, and supportive care such as fluids and oxygen. In severe cases, hospitalization may be necessary.

Prevention is key in avoiding poisoning. This includes proper storage and disposal of household chemicals, using protective gear when working with hazardous substances, and avoiding exposure to known poisons such as certain plants and animals. Education and awareness are also important in preventing poisoning, such as understanding the symptoms of poisoning and seeking medical attention immediately if suspected.

1. Infection: Bacterial or viral infections can develop after surgery, potentially leading to sepsis or organ failure.
2. Adhesions: Scar tissue can form during the healing process, which can cause bowel obstruction, chronic pain, or other complications.
3. Wound complications: Incisional hernias, wound dehiscence (separation of the wound edges), and wound infections can occur.
4. Respiratory problems: Pneumonia, respiratory failure, and atelectasis (collapsed lung) can develop after surgery, particularly in older adults or those with pre-existing respiratory conditions.
5. Cardiovascular complications: Myocardial infarction (heart attack), cardiac arrhythmias, and cardiac failure can occur after surgery, especially in high-risk patients.
6. Renal (kidney) problems: Acute kidney injury or chronic kidney disease can develop postoperatively, particularly in patients with pre-existing renal impairment.
7. Neurological complications: Stroke, seizures, and neuropraxia (nerve damage) can occur after surgery, especially in patients with pre-existing neurological conditions.
8. Pulmonary embolism: Blood clots can form in the legs or lungs after surgery, potentially causing pulmonary embolism.
9. Anesthesia-related complications: Respiratory and cardiac complications can occur during anesthesia, including respiratory and cardiac arrest.
10. delayed healing: Wound healing may be delayed or impaired after surgery, particularly in patients with pre-existing medical conditions.

It is important for patients to be aware of these potential complications and to discuss any concerns with their surgeon and healthcare team before undergoing surgery.

Vomiting can be caused by a variety of factors, such as:

1. Infection: Viral or bacterial infections can inflame the stomach and intestines, leading to vomiting.
2. Food poisoning: Consuming contaminated or spoiled food can cause vomiting.
3. Motion sickness: Traveling by car, boat, plane, or other modes of transportation can cause motion sickness, which leads to vomiting.
4. Alcohol or drug overconsumption: Drinking too much alcohol or taking certain medications can irritate the stomach and cause vomiting.
5. Pregnancy: Hormonal changes during pregnancy can cause nausea and vomiting, especially during the first trimester.
6. Other conditions: Vomiting can also be a symptom of other medical conditions such as appendicitis, pancreatitis, and migraines.

When someone is vomiting, they may experience:

1. Nausea: A feeling of queasiness or sickness in the stomach.
2. Abdominal pain: Crampy or sharp pain in the abdomen.
3. Diarrhea: Loose, watery stools.
4. Dehydration: Loss of fluids and electrolytes.
5. Headache: A throbbing headache can occur due to dehydration.
6. Fatigue: Weakness and exhaustion.

Treatment for vomiting depends on the underlying cause, but may include:

1. Fluid replacement: Drinking fluids to replenish lost electrolytes and prevent dehydration.
2. Medications: Anti-inflammatory drugs or antibiotics may be prescribed to treat infections or other conditions causing vomiting.
3. Rest: Resting the body and avoiding strenuous activities.
4. Dietary changes: Avoiding certain foods or substances that trigger vomiting.
5. Hospitalization: In severe cases of vomiting, hospitalization may be necessary to monitor and treat underlying conditions.

It is important to seek medical attention if the following symptoms occur with vomiting:

1. Severe abdominal pain.
2. Fever above 101.5°F (38.6°C).
3. Blood in vomit or stools.
4. Signs of dehydration, such as excessive thirst, dark urine, or dizziness.
5. Vomiting that lasts for more than 2 days.
6. Frequent vomiting with no relief.

* Headaches or migraines
* Dental problems (e.g., toothache, abscess)
* Sinusitis
* Eye problems (e.g., conjunctivitis, styes)
* Infections (e.g., colds, flu)
* Allergies
* Injuries or trauma
* Neurological disorders (e.g., trigeminal neuralgia, Bell's palsy)
* Cancer

The types of facial pain include:

* Constant pain: Pain that is present all the time and does not change in intensity.
* Intermittent pain: Pain that comes and goes and may be triggered by specific activities or stimuli.
* Sharp pain: Pain that is sudden and stabbing.
* Dull pain: Pain that is ongoing and aching.
* Throbbing pain: Pain that is pulsing or beating, often with a rhythmic pattern.

The causes of facial pain can vary depending on the location and severity of the pain. Some common causes include:

* Muscle tension or spasm
* Nerve irritation or compression
* Inflammation or infection
* Injury or trauma to the face
* Neurological disorders (e.g., trigeminal neuralgia, Bell's palsy)
* Dental problems (e.g., toothache, abscess)

The diagnosis of facial pain is based on a combination of medical history, physical examination, and diagnostic tests such as X-rays, CT scans, or MRI scans. Treatment for facial pain depends on the underlying cause and may include medications (e.g., pain relievers, antibiotics), lifestyle changes (e.g., avoiding triggers), or surgical intervention (e.g., to remove a tumor).

There are different types of amnesia, including:

1. Retrograde amnesia: loss of memory of events that occurred before the onset of amnesia.
2. Anterograde amnesia: inability to form new memories after the onset of amnesia.
3. Transient global amnesia: temporary and reversible loss of memory due to a specific cause, such as a stroke or a head injury.
4. Korsakoff's syndrome: a condition caused by alcoholism and malnutrition that affects the hippocampus and the ability to form new memories.
5. Dissociative amnesia: loss of memory due to psychological trauma or stress, often accompanied by dissociation from reality.

The symptoms of amnesia can vary depending on the underlying cause and the severity of the condition. Some common symptoms include:

1. Difficulty learning new information
2. Forgetting recent events or conversations
3. Inability to recall past events or experiences
4. Confusion and disorientation
5. Difficulty with problem-solving and decision-making

The diagnosis of amnesia is based on a combination of medical history, physical examination, and neuropsychological tests. Imaging studies such as CT or MRI scans may also be used to rule out other causes of memory loss.

Treatment for amnesia depends on the underlying cause and may include:

1. Medications to manage symptoms such as anxiety, depression, or cognitive impairment.
2. Cognitive rehabilitation therapy to improve memory and problem-solving skills.
3. Behavioral interventions to help the individual adapt to their condition.
4. In some cases, surgery may be necessary to treat the underlying cause of amnesia, such as a tumor or a blood clot.

Overall, amnesia can have a significant impact on an individual's quality of life, but with proper diagnosis and treatment, many people are able to manage their symptoms and lead fulfilling lives.

There are several types of fistulas, including:

1. Anal fistula: a connection between the anus and the skin around it, usually caused by an abscess or infection.
2. Rectovaginal fistula: a connection between the rectum and the vagina, often seen in women who have had radiation therapy for cancer.
3. Vesicovaginal fistula: a connection between the bladder and the vagina, often caused by obstetric injuries or surgery.
4. Enterocutaneous fistula: a connection between the intestine and the skin, often seen in patients with inflammatory bowel disease or cancer.
5. Fistula-in-ano: a connection between the rectum and the skin around the anus, often caused by chronic constipation or previous surgery.

Symptoms of fistulas can include pain, bleeding, discharge, and difficulty controlling bowel movements. Treatment depends on the type and location of the fistula, but may include antibiotics, surgery, or other interventional procedures.

The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the World Health Organization (WHO). In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.

In this article, we will explore the definition and impact of chronic diseases, as well as strategies for managing and living with them. We will also discuss the importance of early detection and prevention, as well as the role of healthcare providers in addressing the needs of individuals with chronic diseases.

What is a Chronic Disease?

A chronic disease is a condition that lasts for an extended period of time, often affecting daily life and activities. Unlike acute diseases, which have a specific beginning and end, chronic diseases are long-term and persistent. Examples of chronic diseases include:

1. Diabetes
2. Heart disease
3. Arthritis
4. Asthma
5. Cancer
6. Chronic obstructive pulmonary disease (COPD)
7. Chronic kidney disease (CKD)
8. Hypertension
9. Osteoporosis
10. Stroke

Impact of Chronic Diseases

The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the WHO. In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.

Chronic diseases can also have a significant impact on an individual's quality of life, limiting their ability to participate in activities they enjoy and affecting their relationships with family and friends. Moreover, the financial burden of chronic diseases can lead to poverty and reduce economic productivity, thus having a broader societal impact.

Addressing Chronic Diseases

Given the significant burden of chronic diseases, it is essential that we address them effectively. This requires a multi-faceted approach that includes:

1. Lifestyle modifications: Encouraging healthy behaviors such as regular physical activity, a balanced diet, and smoking cessation can help prevent and manage chronic diseases.
2. Early detection and diagnosis: Identifying risk factors and detecting diseases early can help prevent or delay their progression.
3. Medication management: Effective medication management is crucial for controlling symptoms and slowing disease progression.
4. Multi-disciplinary care: Collaboration between healthcare providers, patients, and families is essential for managing chronic diseases.
5. Health promotion and disease prevention: Educating individuals about the risks of chronic diseases and promoting healthy behaviors can help prevent their onset.
6. Addressing social determinants of health: Social determinants such as poverty, education, and employment can have a significant impact on health outcomes. Addressing these factors is essential for reducing health disparities and improving overall health.
7. Investing in healthcare infrastructure: Investing in healthcare infrastructure, technology, and research is necessary to improve disease detection, diagnosis, and treatment.
8. Encouraging policy change: Policy changes can help create supportive environments for healthy behaviors and reduce the burden of chronic diseases.
9. Increasing public awareness: Raising public awareness about the risks and consequences of chronic diseases can help individuals make informed decisions about their health.
10. Providing support for caregivers: Chronic diseases can have a significant impact on family members and caregivers, so providing them with support is essential for improving overall health outcomes.

Conclusion

Chronic diseases are a major public health burden that affect millions of people worldwide. Addressing these diseases requires a multi-faceted approach that includes lifestyle changes, addressing social determinants of health, investing in healthcare infrastructure, encouraging policy change, increasing public awareness, and providing support for caregivers. By taking a comprehensive approach to chronic disease prevention and management, we can improve the health and well-being of individuals and communities worldwide.

The term "decerebrate" comes from the Latin word "cerebrum," which means brain. In this context, the term refers to a state where the brain is significantly damaged or absent, leading to a loss of consciousness and other cognitive functions.

Some common symptoms of the decerebrate state include:

* Loss of consciousness
* Flaccid paralysis (loss of muscle tone)
* Dilated pupils
* Lack of responsiveness to stimuli
* Poor or absent reflexes
* Inability to speak or communicate

The decerebrate state can be caused by a variety of factors, including:

* Severe head injury
* Stroke or cerebral vasculature disorders
* Brain tumors or cysts
* Infections such as meningitis or encephalitis
* Traumatic brain injury

Treatment for the decerebrate state is typically focused on addressing the underlying cause of the condition. This may involve medications to control seizures, antibiotics for infections, or surgery to relieve pressure on the brain. In some cases, the decerebrate state may be a permanent condition, and individuals may require long-term care and support.

* Anxiety
* Depression
* Fatigue
* Insomnia
* Muscle and bone pain
* Nausea and vomiting
* Seizures (in severe cases)
* Sweating
* Tremors

The specific symptoms of substance withdrawal syndrome can vary depending on the substance being withdrawn from, but some common symptoms include:

* Alcohol: tremors, anxiety, insomnia, nausea and vomiting, headaches, and seizures
* Opioids: withdrawal symptoms can include anxiety, muscle aches, sweating, nausea and vomiting, diarrhea, and depression
* Benzodiazepines: withdrawal symptoms can include anxiety, insomnia, tremors, and seizures

The diagnosis of substance withdrawal syndrome is typically made based on the patient's history of substance use and the presence of withdrawal symptoms. A healthcare provider may also order laboratory tests to rule out other conditions that may be causing the symptoms. Treatment for substance withdrawal syndrome usually involves supportive care, such as rest, hydration, and pain management, as well as medication to manage withdrawal symptoms. In some cases, medical professionals may also recommend a gradual tapering of the substance over a period of time to minimize withdrawal symptoms.

It is important for individuals who are experiencing withdrawal symptoms to seek medical attention as soon as possible, as untreated withdrawal can lead to serious complications, such as seizures and dehydration. With appropriate treatment, most individuals with substance withdrawal syndrome can recover fully and successfully overcome their addiction.

Types of Substance-Related Disorders:

1. Alcohol Use Disorder (AUD): A chronic disease characterized by the excessive consumption of alcohol, leading to impaired control over drinking, social or personal problems, and increased risk of health issues.
2. Opioid Use Disorder (OUD): A chronic disease characterized by the excessive use of opioids, such as prescription painkillers or heroin, leading to withdrawal symptoms when the substance is not available.
3. Stimulant Use Disorder: A chronic disease characterized by the excessive use of stimulants, such as cocaine or amphetamines, leading to impaired control over use and increased risk of adverse effects.
4. Cannabis Use Disorder: A chronic disease characterized by the excessive use of cannabis, leading to impaired control over use and increased risk of adverse effects.
5. Hallucinogen Use Disorder: A chronic disease characterized by the excessive use of hallucinogens, such as LSD or psilocybin mushrooms, leading to impaired control over use and increased risk of adverse effects.

Causes and Risk Factors:

1. Genetics: Individuals with a family history of substance-related disorders are more likely to develop these conditions.
2. Mental health: Individuals with mental health conditions, such as depression or anxiety, may be more likely to use substances as a form of self-medication.
3. Environmental factors: Exposure to substances at an early age, peer pressure, and social environment can increase the risk of developing a substance-related disorder.
4. Brain chemistry: Substance use can alter brain chemistry, leading to dependence and addiction.

Symptoms:

1. Increased tolerance: The need to use more of the substance to achieve the desired effect.
2. Withdrawal: Experiencing symptoms such as anxiety, irritability, or nausea when the substance is not present.
3. Loss of control: Using more substance than intended or for longer than intended.
4. Neglecting responsibilities: Neglecting responsibilities at home, work, or school due to substance use.
5. Continued use despite negative consequences: Continuing to use the substance despite physical, emotional, or financial consequences.

Diagnosis:

1. Physical examination: A doctor may perform a physical examination to look for signs of substance use, such as track marks or changes in heart rate and blood pressure.
2. Laboratory tests: Blood or urine tests can confirm the presence of substances in the body.
3. Psychological evaluation: A mental health professional may conduct a psychological evaluation to assess symptoms of substance-related disorders and determine the presence of co-occurring conditions.

Treatment:

1. Detoxification: A medically-supervised detox program can help manage withdrawal symptoms and reduce the risk of complications.
2. Medications: Medications such as methadone or buprenorphine may be prescribed to manage withdrawal symptoms and reduce cravings.
3. Behavioral therapy: Cognitive-behavioral therapy (CBT) and contingency management are effective behavioral therapies for treating substance use disorders.
4. Support groups: Joining a support group such as Narcotics Anonymous can provide a sense of community and support for individuals in recovery.
5. Lifestyle changes: Making healthy lifestyle changes such as regular exercise, healthy eating, and getting enough sleep can help manage withdrawal symptoms and reduce cravings.

It's important to note that diagnosis and treatment of substance-related disorders is a complex process and should be individualized based on the specific needs and circumstances of each patient.

Types of congenital heart defects include:

1. Ventricular septal defect (VSD): A hole in the wall between the two lower chambers of the heart, allowing abnormal blood flow.
2. Atrial septal defect (ASD): A hole in the wall between the two upper chambers of the heart, also allowing abnormal blood flow.
3. Tetralogy of Fallot: A combination of four heart defects, including VSD, pulmonary stenosis (narrowing of the pulmonary valve), and abnormal development of the infundibulum (a part of the heart that connects the ventricles to the pulmonary artery).
4. Transposition of the great vessels: A condition in which the aorta and/or pulmonary artery are placed in the wrong position, disrupting blood flow.
5. Hypoplastic left heart syndrome (HLHS): A severe defect in which the left side of the heart is underdeveloped, resulting in insufficient blood flow to the body.
6. Pulmonary atresia: A condition in which the pulmonary valve does not form properly, blocking blood flow to the lungs.
7. Truncus arteriosus: A rare defect in which a single artery instead of two (aorta and pulmonary artery) arises from the heart.
8. Double-outlet right ventricle: A condition in which both the aorta and the pulmonary artery arise from the right ventricle instead of the left ventricle.

Causes of congenital heart defects are not fully understood, but genetics, environmental factors, and viral infections during pregnancy may play a role. Diagnosis is typically made through fetal echocardiography or cardiac ultrasound during pregnancy or after birth. Treatment depends on the type and severity of the defect and may include medication, surgery, or heart transplantation. With advances in medical technology and treatment, many children with congenital heart disease can lead active, healthy lives into adulthood.


Some common examples of respiration disorders include:

1. Asthma: A chronic condition that causes inflammation and narrowing of the airways, leading to wheezing, coughing, and shortness of breath.
2. Chronic obstructive pulmonary disease (COPD): A progressive lung disease that makes it difficult to breathe, caused by exposure to pollutants such as cigarette smoke.
3. Pneumonia: An infection of the lungs that can cause fever, chills, and difficulty breathing.
4. Bronchitis: Inflammation of the airways that can cause coughing and difficulty breathing.
5. Emphysema: A condition where the air sacs in the lungs are damaged, making it difficult to breathe.
6. Sleep apnea: A sleep disorder that causes a person to stop breathing for short periods during sleep, leading to fatigue and other symptoms.
7. Cystic fibrosis: A genetic disorder that affects the respiratory system and digestive system, causing thick mucus buildup and difficulty breathing.
8. Pulmonary fibrosis: A condition where the lungs become scarred and stiff, making it difficult to breathe.
9. Tuberculosis (TB): A bacterial infection that primarily affects the lungs and can cause coughing, fever, and difficulty breathing.
10. Lung cancer: A type of cancer that originates in the lungs and can cause symptoms such as coughing, chest pain, and difficulty breathing.

These are just a few examples of respiration disorders, and there are many other conditions that can affect the respiratory system and cause breathing difficulties. If you are experiencing any symptoms of respiration disorders, it is important to seek medical attention to receive an accurate diagnosis and appropriate treatment.

There are many different types of seizures, each with its own unique set of symptoms. Some common types of seizures include:

1. Generalized seizures: These seizures affect both sides of the brain and can cause a range of symptoms, including convulsions, loss of consciousness, and muscle stiffness.
2. Focal seizures: These seizures affect only one part of the brain and can cause more specific symptoms, such as weakness or numbness in a limb, or changes in sensation or vision.
3. Tonic-clonic seizures: These seizures are also known as grand mal seizures and can cause convulsions, loss of consciousness, and muscle stiffness.
4. Absence seizures: These seizures are also known as petit mal seizures and can cause a brief loss of consciousness or staring spell.
5. Myoclonic seizures: These seizures can cause sudden, brief muscle jerks or twitches.
6. Atonic seizures: These seizures can cause a sudden loss of muscle tone, which can lead to falls or drops.
7. Lennox-Gastaut syndrome: This is a rare and severe form of epilepsy that can cause multiple types of seizures, including tonic, atonic, and myoclonic seizures.

Seizures can be diagnosed through a combination of medical history, physical examination, and diagnostic tests such as electroencephalography (EEG) or imaging studies. Treatment for seizures usually involves anticonvulsant medications, but in some cases, surgery or other interventions may be necessary.

Overall, seizures are a complex and multifaceted symptom that can have a significant impact on an individual's quality of life. It is important to seek medical attention if you or someone you know is experiencing seizures, as early diagnosis and treatment can help to improve outcomes and reduce the risk of complications.

There are different types of anoxia, including:

1. Cerebral anoxia: This occurs when the brain does not receive enough oxygen, leading to cognitive impairment, confusion, and loss of consciousness.
2. Pulmonary anoxia: This occurs when the lungs do not receive enough oxygen, leading to shortness of breath, coughing, and chest pain.
3. Cardiac anoxia: This occurs when the heart does not receive enough oxygen, leading to cardiac arrest and potentially death.
4. Global anoxia: This is a complete lack of oxygen to the entire body, leading to widespread tissue damage and death.

Treatment for anoxia depends on the underlying cause and the severity of the condition. In some cases, hospitalization may be necessary to provide oxygen therapy, pain management, and other supportive care. In severe cases, anoxia can lead to long-term disability or death.

Prevention of anoxia is important, and this includes managing underlying medical conditions such as heart disease, diabetes, and respiratory problems. It also involves avoiding activities that can lead to oxygen deprivation, such as scuba diving or high-altitude climbing, without proper training and equipment.

In summary, anoxia is a serious medical condition that occurs when there is a lack of oxygen in the body or specific tissues or organs. It can cause cell death and tissue damage, leading to serious health complications and even death if left untreated. Early diagnosis and treatment are crucial to prevent long-term disability or death.

1. Muscular dystrophy: A group of genetic disorders characterized by progressive muscle weakness and degeneration.
2. Myopathy: A condition where the muscles become damaged or diseased, leading to muscle weakness and wasting.
3. Fibromyalgia: A chronic condition characterized by widespread pain, fatigue, and muscle stiffness.
4. Rhabdomyolysis: A condition where the muscle tissue is damaged, leading to the release of myoglobin into the bloodstream and potentially causing kidney damage.
5. Polymyositis/dermatomyositis: Inflammatory conditions that affect the muscles and skin.
6. Muscle strain: A common injury caused by overstretching or tearing of muscle fibers.
7. Cervical dystonia: A movement disorder characterized by involuntary contractions of the neck muscles.
8. Myasthenia gravis: An autoimmune disorder that affects the nerve-muscle connection, leading to muscle weakness and fatigue.
9. Oculopharyngeal myopathy: A condition characterized by weakness of the muscles used for swallowing and eye movements.
10. Inclusion body myositis: An inflammatory condition that affects the muscles, leading to progressive muscle weakness and wasting.

These are just a few examples of the many different types of muscular diseases that can affect individuals. Each condition has its unique set of symptoms, causes, and treatment options. It's important for individuals experiencing muscle weakness or wasting to seek medical attention to receive an accurate diagnosis and appropriate care.

1. Respiratory distress syndrome (RDS): This is a breathing disorder that occurs when the baby's lungs are not fully developed, causing difficulty in breathing. RDS can be treated with oxygen therapy and other medical interventions.
2. Jaundice: Jaundice is a yellowish tint to the skin and eyes caused by high levels of bilirubin in the blood. It is a common condition in newborns, but if left untreated, it can lead to brain damage. Treatment may involve phototherapy or blood exchange transfusions.
3. Neonatal jaundice: This is a milder form of jaundice that occurs in the first few days of life. It usually resolves on its own within a week, but if it persists, treatment may be necessary.
4. Premature birth: Premature babies are at risk for various health issues, including respiratory distress syndrome, intraventricular hemorrhage (bleeding in the brain), and retinopathy (eye problems).
5. Congenital heart disease: This is a heart defect that occurs during fetal development. It can range from mild to severe and may require surgical intervention.
6. Infections: Newborns are susceptible to bacterial and viral infections, such as group B strep, pneumonia, and urinary tract infections. These can be treated with antibiotics if caught early.
7. Hypoglycemia (low blood sugar): This is a condition that occurs when the baby's blood sugar levels drop too low. It can cause seizures, lethargy, and other symptoms. Treatment involves feeding or providing glucose supplements.
8. Hyperbilirubinemia (high bilirubin levels): Bilirubin is a yellow pigment produced during the breakdown of red blood cells. High levels can cause jaundice, which can lead to kernicterus, a condition that can cause brain damage and hearing loss.
9. Intracranial hemorrhage (bleeding in the brain): This is a serious condition that occurs when there is bleeding in the baby's brain. It can be caused by various conditions, including premature birth, abruption, and vasculitis.
10. Meconium aspiration: This occurs when the baby inhales a mixture of meconium (a substance produced by the intestines) and amniotic fluid during delivery. It can cause respiratory problems and other complications.

It's important to note that while these conditions can be serious, many babies born at 37 weeks gestation do not experience any complications. Proper prenatal care and a healthy pregnancy can help reduce the risk of these conditions.

There are several types of respiratory insufficiency, including:

1. Hypoxemic respiratory failure: This occurs when the lungs do not take in enough oxygen, resulting in low levels of oxygen in the bloodstream.
2. Hypercapnic respiratory failure: This occurs when the lungs are unable to remove enough carbon dioxide from the bloodstream, leading to high levels of carbon dioxide in the bloodstream.
3. Mixed respiratory failure: This occurs when both hypoxemic and hypercapnic respiratory failure occur simultaneously.

Treatment for respiratory insufficiency depends on the underlying cause and may include medications, oxygen therapy, mechanical ventilation, and other supportive care measures. In severe cases, lung transplantation may be necessary. It is important to seek medical attention if symptoms of respiratory insufficiency are present, as early intervention can improve outcomes and prevent complications.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

There are two types of heart arrest:

1. Asystole - This is when the heart stops functioning completely and there is no electrical activity in the heart.
2. Pulseless ventricular tachycardia or fibrillation - This is when the heart is still functioning but there is no pulse and the rhythm is abnormal.

Heart arrest can be diagnosed through various tests such as electrocardiogram (ECG), blood tests, and echocardiography. Treatment options for heart arrest include cardiopulmonary resuscitation (CPR), defibrillation, and medications to restore a normal heart rhythm.

In severe cases of heart arrest, the patient may require advanced life support measures such as mechanical ventilation and cardiac support devices. The prognosis for heart arrest is generally poor, especially if it is not treated promptly and effectively. However, with proper treatment and support, some patients can recover and regain normal heart function.

Coronary disease is often caused by a combination of genetic and lifestyle factors, such as high blood pressure, high cholesterol levels, smoking, obesity, and a lack of physical activity. It can also be triggered by other medical conditions, such as diabetes and kidney disease.

The symptoms of coronary disease can vary depending on the severity of the condition, but may include:

* Chest pain or discomfort (angina)
* Shortness of breath
* Fatigue
* Swelling of the legs and feet
* Pain in the arms and back

Coronary disease is typically diagnosed through a combination of physical examination, medical history, and diagnostic tests such as electrocardiograms (ECGs), stress tests, and cardiac imaging. Treatment for coronary disease may include lifestyle changes, medications to control symptoms, and surgical procedures such as angioplasty or bypass surgery to improve blood flow to the heart.

Preventative measures for coronary disease include:

* Maintaining a healthy diet and exercise routine
* Quitting smoking and limiting alcohol consumption
* Managing high blood pressure, high cholesterol levels, and other underlying medical conditions
* Reducing stress through relaxation techniques or therapy.

Some increases in fentanyl deaths do not involve prescription fentanyl but are related to illicitly made fentanyl that is being ... The flow of fentanyl mainly originates in Chinese factories which produce fentanyl or fentanyl precursors; it is then ... The patches should be kept away from children, who are most at risk from fentanyl overdose. In the US, fentanyl and fentanyl ... "Fentanyl, Fentanyl Citrate, Fentanyl Hydrochloride". The American Society of Health-System Pharmacists. Archived from the ...
... such as cyclopropryl fentanyl or cyclopentyl fentanyl, or any other fentanyl analogue derived from a reaction of 4-ANPP with a ... Armenian P, Vo KT, Barr-Walker J, Lynch KL (May 2018). "Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive ... or possess fentanyl analogs. Several jurisdictions have implemented analogue law controls of fentanyl analogues in an attempt ... Fentanyl analogues". New Zealand Misuse of Drugs Act 1975. "Schedules of Controlled Substances: Temporary Placement of Fentanyl ...
Synthetic opioids like fentanyl and carfentanil are much more potent than prescription opioids and heroin. There is some debate ... Fentanyl. Image 4 of 17. US DEA (Drug Enforcement Administration). Boyer EW, McCance-Katz EF, Marcus S (January 2010). " ... October 2021.{{cite web}}: CS1 maint: url-status (link) Armenian P, Vo KT, Barr-Walker J, Lynch KL (May 2018). "Fentanyl, ... An opioid overdose is toxicity due to excessive consumption of opioids, such as morphine, codeine, heroin, fentanyl, tramadol, ...
... is an analogue of fentanyl and is also known as (4-methoxycarbonyl)fentanyl. Related analogues of fentanyl include ... Over three hundred cases of overdose related to fentanyl and fentanyl analogues were reported between August and November 2016 ... "Fentanyl drug profile". EMCDDA. Stanley TH, Egan TD, Van Aken H (February 2008). "A tribute to Dr. Paul A. J. Janssen: ... Myers, Steven Lee (1 December 2019). "China Cracks Down on Fentanyl. But Is It Enough to End the U.S. Epidemic?". The New York ...
Fentanyl. Image 4 of 17. US DEA (Drug Enforcement Administration). Kosten TR, Haile CN. Opioid-Related Disorders. In: Kasper D ... Non-methadone synthetics is a category dominated by illegally acquired fentanyl, and has been excluded. US yearly opioid ... Opioids include substances such as heroin, morphine, fentanyl, codeine, dihydrocodeine, oxycodone, and hydrocodone. A useful ...
"Fentanyl". www.drugbank.ca. Archived from the original on 2017-07-11. Retrieved 2017-09-29. LD50 for various snakes Archived ...
Jason Davis, 35, American actor (Recess, Beverly Hills Ninja, Mafia!), fentanyl overdose. Andrew Fairfield, 76, American bishop ... Fentanyl Effects,' Coroner Says Andrew Hedlter Fairfield Harry Gregg, former Manchester United goalkeeper and Munich air ...
"Fentanyl landscape , PiHKAL · info". isomerdesign.com. (All articles with dead external links, Articles with dead external ... Gray death is a slang term which refers to a potent mixture of synthetic opioids, for example benzimidazole opioids or fentanyl ... A mixture of drugs misleadingly called 2C-B had been laced with fentanyl in Argentina. In February 2022, 20 people in Argentina ... "Bethlehem police find first case of deadly drug known as 'gray death'".[permanent dead link] "Fentanyl and 2CB, Worrying New ...
Heroin, fentanyl and other opioids have also attributed to an overall increase in violent crime, property crime and ... ". "Kentucky shatters its fatal overdose record; fentanyl blamed". spectrumnews1.com. "courier-journal.com-Jefferson County ...
Utilization of a radioreceptor assay for the analysis of fentanyl analogs in urine". J Anal Toxicol. 16 (1): 36-41. doi:10.1093 ... Brine GA, Boldt KG, Huang PT, Sawyer DK, Carroll FI (2009). "Carbon-13 nuclear magnetic resonance spectra of fentanyl analogs ... Shoemaker, Alyssa K. (2020). Cholinesterase Based System for Fentanyl Detection (MS thesis). State University of New York at ... Higashikawa Y, Suzuki S (June 2008). "Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related ...
Fentanyl is an opioid with rapid onset of pain relief; it is often used to treat breakthrough pain. Fentanyl patches release ... Several deaths or life-threatening overdoses have been linked to misuse of fentanyl patches. Fentanyl patches are indicated ... Fentanyl is often used for opioid-tolerant patients. Most obscure of all are patched containing Nitroglycerin, also known as ... 15 January 2021). "Fentanyl Transdermal Patch". MedlinePlus. Retrieved 3 August 2021. US Department of Health and Human ...
Scott Higham; Sari Horwitz; Katie Zezima (March 13, 2019). "The Fentanyl Failure". The Washington Post. Retrieved March 14, ... Prosecutions dropped, drug enforcement agent morale dropped, and fentanyl and heroin overdoses soared, reported The Washington ... prosecutors would no longer take the lower-level cases and morale among his drug agents plummeted as heroin and fentanyl ...
Utilization of a radioreceptor assay for the analysis of fentanyl analogs in urine". J Anal Toxicol. 16 (1): 36-41. doi:10.1093 ... Brine GA, Boldt KG, Huang PT, Sawyer DK, Carroll FI (2009). "Carbon-13 nuclear magnetic resonance spectra of fentanyl analogs ... Higashikawa Y, Suzuki S (June 2008). "Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related ... It is an analog of fentanyl and remifentanil. 3-Methylbutyrfentanyl 4-Fluorobutyrfentanyl 4-Fluorofentanyl α-Methylfentanyl ...
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Utilization of a radioreceptor assay for the analysis of fentanyl analogs in urine". J Anal Toxicol. 16 (1): 36-41. doi:10.1093 ... Brine GA, Boldt KG, Huang PT, Sawyer DK, Carroll FI (2009). "Carbon-13 nuclear magnetic resonance spectra of fentanyl analogs ... Higashikawa Y, Suzuki S (June 2008). "Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related ... Alburges ME, Hanson GR, Gibb JW, Sakashita CO, Rollins DE (1992). "Fentanyl receptor assay. II. ...
"DrugsData.org: Results : Lab Test Results for Fentanyl". www.drugsdata.org. Retrieved 2021-02-19. Schulz W. "Fentanyl". List of ... is a direct precursor to fentanyl and some fentanyl analogues such as acetylfentanyl. It is commonly found as a contaminant in ... This product is reacted with propionyl chloride to form fentanyl. "Red list". www.incb.org. Retrieved 2021-02-20. "4-ANPP". www ... 4-ANPP is useful in the synthesis of pharmaceuticals, primarily fentanyl and its analogs. Paul Janssen (founder of Janssen ...
ISBN 978-0-471-89979-2. Stanley TH (December 2014). "The fentanyl story". The Journal of Pain. 15 (12): 1215-26. doi:10.1016/j. ... Janssen created fentanyl in 1960, which proved to be ten times more potent than phenoperidine. In 1959, the combination of ... the use of that mixture boomed in early 1960s but was overtaken by the combination of fentanyl and droperidol, which was widely ...
... primarily fentanyl and its analogs. Paul Janssen (founder of Janssen Pharmaceutica) first synthesized fentanyl in 1960 from NPP ... Schulz W. "Fentanyl". List of Top Pharmaceuticals. Chemical & Engineering News. Beckett AH, Casy AF, Kirk G (February 1959). " ... Because of its possible use in the illicit manufacture of fentanyl, NPP was placed onto the list of controlled chemicals in the ... It is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs such as fentanyl. ...
The potency of fentanyl has led to the mistaken belief that exposure to fentanyl by touch can cause an overdose, a myth that ... Fentanyl has surpassed heroin as a killer in several locales: in all of 2014 the CDC identified 998 fatal fentanyl overdoses in ... If you are using oxycodone and take fentanyl not knowing it is fentanyl, that is an overdose waiting to happen. Each of those ... "Why fentanyl is deadlier than heroin, in a single photo", Stat, September 29, 2016 "Fentanyl drug profile", The European ...
Fentanyl' was released with an animated music video on January 24, 2020, announcing their new album 'Miss Fortune' would be ... "Fentanyl (Official Music Video)". Youtube. "Laugh at My Lessons (Single)". Spotify. 13 March 2020. "Miss Fortune signs to We ... "Fentanyl by Miss Fortune". Spotify. 24 January 2020. Retrieved 27 July 2020. "Laugh at My Lessons by Miss Fortune". Spotify. 13 ... "Fentanyl" (2019) "Laugh at My Lessons" (2020) "Your Reminder" (2020) "The Day The Sun Died" (2021) Florence + The Sphinx: ...
... (N-Phenylpropylnorfentanyl, Fentanyl propyl analogue) is an opioid derivative which has been sold as a designer ... "Fentanyl-Related Substances with no Currently Known Legitimate Uses" (PDF). International Narcotics Control Board (INCB). 15 ... It is a homologue of fentanyl, with similar analgesic and sedative effects but lower potency, around 14x stronger than ... "Identification of fentanyl derivatives". Journal of Forensic Sciences. 31 (2): 511-28. doi:10.1520/JFS12283J. PMID 3711827. " ...
... fentanyl, and 500 times as potent as morphine. Structurally, sufentanil differs from fentanyl through the addition of a ... "Fentanyl Citrate - Drug Summary". pdr.net. Retrieved 23 October 2015. Davio, Kelly (November 5, 2018). "FDA Approves Painkiller ... "Fentanyl analogs: structure-activity-relationship study". Curr Med Chem. 16 (9): 2468-2474. doi:10.2174/092986709788682074. ... FDA approves a new opioid 10 times more powerful than fentanyl". Pharmalot. Retrieved November 2, 2018. Savoia G, Loreto M, ...
Harrison, Teva (2018-08-23). "The Other Side of Fentanyl". The Walrus. Retrieved 2019-11-07. "Above the Tree Line". Granta ...
Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious ... Armenian P, Vo KT, Barr-Walker J, Lynch KL (2017). "Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive ... Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent ... Isobutyrylfentanyl is an opioid analgesic that is an analog of fentanyl and has been sold online as a designer drug. It is ...
"Freep's fentanyl report is tops". (April 18, 2008). Detroit Free Press, p. 3A. Millikin, Eric. How apocalypse will affect ...
Fentanyl test strips were previously considered drug paraphernalia by Tennessee Code Annotated §39-17-402, which defines terms ... Per TCA §39-17-425, possession of fentanyl test strips was previously a Class A misdemeanor, punishable by up to 11 months, 29 ... "Tennessee Decriminalizes Fentanyl Test Strips". Tennessee Harm Reduction. Retrieved 5 April 2022. "2010 Tennessee Code Title 39 ... Rapid fentanyl test strips are decriminalized in Tennessee. Representative William Lamberth, R-Portland, introduced HB2177 in ...
morphine, fentanyl), muscle relaxerss (ex. diazepam, tizanidine, orphenadrine), and broad-spectrum antibiotics are administered ...
Current evidence for the effectiveness of fentanyl transdermal patches in controlling chronic cancer pain is weak but they may ... Hadley G, Derry S, Moore RA, Wiffen PJ (October 2013). "Transdermal fentanyl for cancer pain". The Cochrane Database of ...
... has similar effects to fentanyl. Side effects of fentanyl analogs are similar to those of fentanyl itself, ... Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent ... 3-Methylbutyrfentanyl 4-Fluorofentanyl α-Methylfentanyl Acetylfentanyl Butyrfentanyl List of fentanyl analogues Drug ... 3-Allylfentanyl is an opioid analgesic that is an analogue of fentanyl. ...
Most recent cases of fentanyl-related harm, overdose, and death in the U.S. are linked to illegally made fentanyl. ... What is fentanyl?. Pharmaceutical fentanyl is a synthetic opioid approved for treating severe pain, typically advanced cancer ... However, most recent cases of fentanyl-related harm, overdose, and death in the U.S. are linked to illegally made fentanyl.2 It ... Tracking Fentanyl and Fentanyl-Related Substances Reported in NFLIS-Drug by State, 2016-2017 ...
Fentanyl: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Use fentanyl exactly as directed. Do not use a larger dose of fentanyl, use the medication more often, or use it for a longer ... Store fentanyl at room temperature and away from excess heat and moisture (not in the bathroom). Do not freeze fentanyl. ... Before using fentanyl,. *tell your doctor and pharmacist if you are allergic to fentanyl patches, injection, nasal spray, ...
Fentanyl is a powerful synthetic opioid analgesic that is similar to morphine but is 50 to 100 times more potent. It is a ... Learn more about fentanyl from the Drug Enforcement Administration.. *Read patient health information on prescription fentanyl ... Find More Resources on Fentanyl and Other Synthetic Opioids *Learn more about fentanyl, overdose, and public health from the ... 8 Because fentanyl is about 50 to 100 times more potent than morphine9,10,11 and a lethal dose of fentanyl can be very small, ...
... the cross-reactivity of fentanyl analogs with these kits is largely unknown. To address this, we conducted a pilot study ... laboratorians and overdose prevention centers rely on commercial immunoassays to detect the presence of fentanyl; however, ... Detection of 58 fentanyl analogs using ARK fentanyl II and Immunalysis fentanyl immunoassays. Williams GR, Akala M, Wolf CE. ... Detection of 30 Fentanyl Analogs by Commercial Immunoassay Kits Rebekah E Wharton 1 , Jerry Casbohm 2 , Ryan Hoffmaster 2 , ...
... transdermal system contains fentanyl, an opioid agonist and a Schedule II controlled substance. As an opioid, fentanyl ... Following fentanyl transdermal system application, the skin under the system absorbs fentanyl, and a depot of fentanyl ... Because of the long half-life of fentanyl when administered as fentanyl transdermal system and hepatic metabolism of fentanyl, ... Because of the long half-life of fentanyl when administered as fentanyl transdermal system, avoid the use of fentanyl ...
Fentanyl can be abused and is subject to criminal diversion. The high content of fentanyl in the patches (fentanyl transdermal ... Fentanyl can be abused and is subject to criminal diversion. The high content of fentanyl in the patches (fentanyl transdermal ... Fentanyl transdermal system is a skin patch that contains fentanyl. Fentanyl is a very strong opioid narcotic pain medicine ... Following fentanyl transdermal system application, the skin under the system absorbs fentanyl, and a depot of fentanyl ...
The mean total fentanyl dose was 9.3 µg in the no-fentanyl arm vs 96.3 µg in the fentanyl arm (P,0.0001). ... High platelet reactivity at 2 hours was 0% without fentanyl compared with more than 20% with fentanyl when assessed by the ... "We did the study because we knew that morphine has an effect, so we thought if fentanyl does too, that may have big ... Dr Robert F Storey (University of Sheffield, UK), who was not involved in the study, said he was unaware of how common fentanyl ...
Fentanyl (Centers for Disease Control and Prevention) Most recent cases of fentanyl-related harm, overdose, and death in the U. ... Fentanyl (National Institute on Drug Abuse) Fentanyl is a powerful synthetic opioid analgesic that is similar to morphine but ... Fentanyl Transdermal Patch Fentanyl patches are used to relieve severe pain in people who are expected to need pain medication ... Fentanyl Fentanyl is used to treat breakthrough pain (sudden episodes of pain that occur despite round the clock ... effects of ...
Most recent cases of fentanyl-related harm, overdose, and death in the U.S. are linked to illegally made fentanyl. ... What is fentanyl?. Pharmaceutical fentanyl is a synthetic opioid approved for treating severe pain, typically advanced cancer ... However, most recent cases of fentanyl-related harm, overdose, and death in the U.S. are linked to illegally made fentanyl.2 It ... Tracking Fentanyl and Fentanyl-Related Substances Reported in NFLIS-Drug by State, 2016-2017 ...
... fentanyl - Featured Topics from the National Center for Health Statistics ... Fentanyl Overdose Death Rates More Than Tripled From 2016 to 2021. Drug overdose death rates involving fentanyl increased by ... "Rapid Release Estimates of Drug Overdose Deaths involving Fentanyl, Methamphetamine, Read More , ...
The results of studies on the effect of epidural fentanyl on breastfeed … ... amounts of fentanyl ingested by the neonate are usually small and are not expected to cause any adverse effects in breastfed ... Limited information indicates that transdermal fentanyl in a dosage of 100 mcg/hour results in undetectable fentanyl ... Fentanyl No authors listed In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child ...
... may actually be fentanyl, or has been adulterated or contaminated with fentanyl. Because fentanyl is about 50 times more potent ... Illicitly manufactured powder fentanyl has been a known adulterant in drugs since 2013, but the extent that fentanyl is found ... HIDTA data does not differentiate between fentanyl and its analogs, nor estimate the amount of fentanyl present in seized ... Illicit fentanyl is highly potent, cheaply made and easily transported, making it a profitable narcotic. While people may seek ...
The results of studies on the effect of epidural fentanyl on breastfeeding initiation and duration are mixed, because of the ... amounts of fentanyl ingested by the neonate are usually small and are not expected to cause any adverse effects in breastfed ... The average fentanyl dosages in the two groups were 97 and 151 mcg in the first stage of labor and 10 and 12 mcg of fentanyl ... The oral bioavailability of fentanyl is 33% in adults. The usual intravenous of fentanyl for an infant is 1 to 2 mcg/kg. ...
Fentanyl is a powerful opioid that can relieve pain or kill the user via overdose. STAT reporters investigate the nationwide ... fentanyl. Fentanyl is more deadly than heroin, and you can see why in a single photo. The opioid has caused havoc in families, ... Doctor accused of indiscriminately prescribing fentanyl agrees to license suspension After patient death, N.J. attorney ... US and China agree to work to block the potent drug fentanyl from coming into America ...
Administrative Supplements for research on fentanyl and derivatives NOT-DA-21-032. NIDA ... In 2013 fentanyl-related deaths were half those of heroin (1 death per 100,000 population), but by 2020 fentanyl-linked deaths ... To evaluate opioid detoxification strategies for patients addicted to fentanyl.. *To study the transition from fentanyl ... Fentanyl was initially used as a "cutting agent" with other opioids (e.g., heroin, counterfeit prescription medications) but ...
The House Judiciary border hearing is among the several planned probes on the GOP has on President Joe Biden, his family and his administration.
... isolate from contaminated fentanyl; lane 9, unrelated control isolate. Patients 2 through 6 received intravenous fentanyl ... Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl1 Lisa L. Maragakis. , ... Patient 1 did not receive intravenous fentanyl and had S. paucimobilis bacteremia with a distinct PFGE pattern. ... Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl. ...
Fentanyl is now the most commonly used drug involved in drug overdoses. The latest numbers from the CDC found that the rate of ... In 2016, 2 in 5 cocaine-related overdose deaths also involved fentanyl. Nearly one-third of fentanyl-related overdoses also ... Fentanyl is now the most commonly used drug involved in drug overdoses, according to a new government report. The latest ... In 2011, fentanyl was involved in just 4% of all drug fatalities. At the time, oxycodone was the most commonly involved drug, ...
May 9 marks National Fentanyl Awareness Day. DEA reminds families to teach kids about the dangers of taking prescription drugs ... May 9 marks National Fentanyl Awareness Day. DEA reminds families to teach kids about the dangers of taking prescription drugs ...
Frustration mounts over fentanyl response in Kelowna , CBC News Loaded. British Columbia. Frustration mounts over fentanyl ... Charlie Hodge said he recently lost a relative to a fentanyl overdose and he fears for another relative who is a drug user. ... A clearly frustrated Kelowna City Council received an official update on the growing fentanyl crisis in the city Monday, as the ...
Production of fentanyl, which relies on chemical ingredients sourced mainly from Wuhan, China, has been particularly hard hit. ... Mexican production of fentanyl and methamphetamine appears especially hard hit. Fentanyl pills disguised as prescription pain ... Death, made in Mexico: Traffickers embrace fentanyl The synthetic drug is the leading culprit in the U.S. opioid epidemic. Most ... Kameron Korte, a spokeswoman for the San Diego field division of the U.S. Drug Enforcement Agency, said fentanyl pills in her ...
Clearly, fentanyl continues to be a problem, Hedegaard said.. (MORE: Crisis: Surge in cocaine mixed with fentanyl has ... Meth, not fentanyl, driving overdose deaths in western US. The nations drug overdose death rate has more than tripled since ... Packets of fentanyl and methamphetamine, which U.S. Customs and Border Protection say they seized from a truck crossing into ... Although fentanyl use remain a pressing concern in the United States, a government report that details regional differences in ...
Peter speaks to a grieving mother who lost her son to fentanyl, an EMT and the director of a sober living organization. ... Peter speaks to a grieving mother who lost her son to fentanyl, an EMT and the director of a sober living organization. ... This week, hes covering the fentanyl crisis, traveling to West Virginia, the state with the most fatal overdoses in the nation ...
FENTANYL CITRATE (UNII: MUN5LYG46H) (FENTANYL - UNII:UF599785JZ) FENTANYL. 20 ug in 1 mL. ... FENTANYL CITRATE injection, solution. Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Out of ... FENTANYL CITRATE injection, solution. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader ... FENTANYL CITRATE injection, solution. If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they ...
Absolute and relative bioavailability of fentanyl buccal tablet and oral transmucosal fentanyl citrate. Darwish M, Kirby M, ... At 20 minutes after spinal sufentanil, epidural sufentanil, spinal fentanyl or epidural fentanyl, the maximum VAS was 19 (7-31 ... At 20 minutes after spinal sufentanil, epidural sufentanil, spinal fentanyl or epidural fentanyl, the maximum VAS was 19 (7-31 ... Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a multiple ascending dose study in ...
... fentanyl pressed into ersatz pain pills, drugs laced with unexpected adulterants, and the proliferation of the fentanyl analogs ... Panicked by Fentanyl Analogs, Biden Embraces the Mandatory Minimums He Claims To Oppose. A House-approved bill that the ... The HALT Fentanyl Act, which the Republican-controlled House of Representatives approved today by a bipartisan 289-133 vote, ... What this means is that, under the HALT Fentanyl Act, a person could be subject to harsh mandatory minimums for distributing ...
Learn about drug interactions between oxymorphone oral and fentanyl transdermal and use the RxList drug interaction checker to ... Drug interactions with oxymorphone oral and fentanyl transdermal. home drug interactions checker , oxymorphone oral and ... All generic drug interactions for fentanyl transdermal (lists will include brand and generic names): ...
Because I lost my son to fentanyl poisoning, and thats the reality of it. Its because of my great loss," Turner said. "Im ... As fentanyl continues to claim lives, Texans work to put an end to its lethal effects ... "House Bill 3908, also known as Tuckers Law, arose when mothers whose children have passed from fentanyl poisoning came to us ... Tuckers Law to require fentanyl awareness education in Texas schools passes House. Stefanie Turner lost her son, Tucker Roe, ...
... were called out the scene of a drug raid in Chula Vista after agents found fentanyl and THC extraction on the property. ... DEA agents arrested one man during their search, and he is suspected of mixing fentanyl with other illegal drugs, according to ... were called out to the scene of a drug raid in Chula Vista after agents found fentanyl and THC extraction on the property. ...
Complex is the leading source for the latest Fentanyl stories. Find the latest news, features, interviews, op-eds, videos, and ... Coolios Cause of Death Revealed to Be Fentanyl, Other Drugs Also Found in His System ...
  • Learn more about fentanyl, overdose, and public health from the Centers for Disease Control and Prevention . (nih.gov)
  • Centers for Disease Control and Prevention (CDC) data show that fentanyl-related mortalities have rapidly increased recently. (nih.gov)
  • Meanwhile, an analysis of U.S. Centers for Disease Control and Prevention data by nonprofit group Families Against Fentanyl showed that overdoses from the drug were the top killer in adults aged 18 to 45 in 2020 in the United States, overtaking suicide, vehicle accidents, and gun violence. (theepochtimes.com)
  • Rates of overdose deaths involving synthetic opioids other than methadone, which includes fentanyl and fentanyl analogs, increased over 22% from 2020 to 2021. (cdc.gov)
  • however, the cross-reactivity of fentanyl analogs with these kits is largely unknown. (nih.gov)
  • To address this, we conducted a pilot study evaluating the detection of 30 fentanyl analogs and metabolites by 19 commercially available kits (9 lateral flow assays, 7 heterogeneous immunoassays and 3 homogenous immunoassays). (nih.gov)
  • In general, the immunoassays tested were able to detect their intended fentanyl analog and some closely related analogs, but more structurally diverse analogs, including 4-methoxy-butyryl fentanyl and 3-methylfentanyl, were not well detected. (nih.gov)
  • For example, examine whether equivalent doses of morphinan-opioids and fentanyl analogs exert differential effects on respiration. (nih.gov)
  • But by endorsing a bill aimed at cracking down on fentanyl analogs, Biden is doing exactly the opposite. (reason.com)
  • China recently announced it would ban substances that mimic fentanyl , typically referred to as fentanyl "analogs. (rand.org)
  • RAND research raises concerns that China's ban on fentanyl analogs won't stem the flow of these substances that are claiming so many lives. (rand.org)
  • Though many fentanyl analogs are reported in drug seizures by crime labs in the United States, fentanyl remains the dominant synthetic opioid. (rand.org)
  • Drug overdose death rates involving fentanyl increased by 279% from 5.7 per 100,000 in 2016 to 21.6 in 2021, according to new data from the CDC's National Center for Health Statistics (NCHS). (cdc.gov)
  • Law enforcement seizures of pills containing illicit fentanyl increased dramatically between January 2018 and December 2021, according to a new study. (nih.gov)
  • The number of individual pills seized by law enforcement increased nearly 50-fold from the first quarter of 2018 to the last quarter of 2021 and the proportion of pills to total seizures more than doubled, with pills representing over a quarter of illicit fentanyl seizures by the end of 2021. (nih.gov)
  • Comparing data from the first quarter of 2018 with the last quarter of 2021, the team found that the number of seizures of pills containing fentanyl increased from 68 to 635, and the total number of individual pills seized by law enforcement increased from 42,202 to 2,089,186. (nih.gov)
  • In a "statement of administration policy" on Monday, the White House called the HALT Fentanyl Act's provisions "critical components of the Biden-Harris Administration's 2021 recommendations to Congress to combat the supply of illicit FRS and save lives. (reason.com)
  • Stefanie Turner lost her son, Tucker Roe, to fentanyl poisoning in 2021 and has pushed for legislation in his honor. (kvue.com)
  • The DEA's latest warning expands on its September 2021 Public Safety Alert on the increase in the availability of fake prescription pills that contain fentanyl. (theepochtimes.com)
  • The federal complaint detailing Martinez's arrest does not tie him directly to any deaths caused by fentanyl, but it does note illegal prescription pills and laced pills like the ones found in his apartment killed 17 people in Austin and surrounding cities between March 2020 and January 2021. (kxan.com)
  • While people may seek out illicit fentanyl intentionally, many people are not aware that the drug they are using - including heroin, cocaine, methamphetamine, or benzodiazepines - may actually be fentanyl, or has been adulterated or contaminated with fentanyl. (nih.gov)
  • Mexican production of fentanyl and methamphetamine appears especially hard hit. (latimes.com)
  • Packets of fentanyl and methamphetamine, which U.S. Customs and Border Protection say they seized from a truck crossing into Arizona from Mexico, is on display during a news conference at the Port of Nogales, Ariz., Jan. 31, 2019. (go.com)
  • Although fentanyl use remain a pressing concern in the United States, a government report that details regional differences in drug overdose deaths shows that in much of the country, methamphetamine is a bigger killer. (go.com)
  • In another, 21 people overdosed at a homeless shelter in Austin, Texas on March 4 after taking crack cocaine and methamphetamine that included fentanyl. (theepochtimes.com)
  • Two individuals are facing drug charges after a vehicle search early Wednesday morning in Westover resulted in the seizure of fentanyl and methamphetamine. (dominionpost.com)
  • Coolio's former longtime manager Jarez Posey told The Associated Press Thursday that Coolio's cause of death was fentanyl and that he also had traces of heroin and methamphetamine in his system. (ktar.com)
  • With fentanyl contaminating all these drugs, we're also seeing a steep rise in mortality from cocaine and methamphetamine use in African Americans, American Indians, and Alaska natives. (nih.gov)
  • People both knowingly consume fentanyl and other synthetic opioids and unknowingly consume them when they are mixed into or sold as other drugs, such as heroin, cocaine, or counterfeit pills. (nih.gov)
  • Because fentanyl is about 50 times more potent than heroin and a lethal dose may be as small as two milligrams, using a drug that has been laced with fentanyl can greatly increase overdose risk. (nih.gov)
  • Fentanyl is more deadly than heroin, and you can see why in a single photo . (statnews.com)
  • In 2013 fentanyl-related deaths were half those of heroin (1 death per 100,000 population), but by 2020 fentanyl-linked deaths have increased 10-fold and double those involving heroin. (nih.gov)
  • Nearly one-third of fentanyl-related overdoses also involved heroin. (cnn.com)
  • Although many experts have pointed to the overprescribing of prescription painkillers as the root of the US opioid crisis, they say it has evolved, first into a heroin crisis and now into a fentanyl epidemic. (cnn.com)
  • Kolodny, who was not involved in the study, pointed to states such as Oklahoma , where overdose deaths from prescription opioids still outnumber heroin and fentanyl deaths. (cnn.com)
  • The study found that illicit drugs like fentanyl and heroin were the leading causes of unintentional overdoses, and prescription drugs were more likely to be involved in suicidal overdoses. (cnn.com)
  • The biggest customers were Mexican drug cartels, which have embraced fentanyl in recent years because it is cheaper and easier to produce than heroin. (latimes.com)
  • Officers seized 24 firearms, 30 kilograms of heroin, 5 kilograms of cocaine and more than $700,000 in cash along with 30 kilograms of fentanyl, according to a press release from the US attorney's office. (cnn.com)
  • It is fentanyl , an opioid that's 50 times more potent than heroin. (nih.gov)
  • Adolescents don't typically use heroin, nor do they seek out fentanyl. (nih.gov)
  • The research also revealed that neural connections extending from the piriform cortex to the orbitofrontal cortex, a region associated with decision-making and heroin relapse, are critical for fentanyl relapse. (nih.gov)
  • Because of the risk of respiratory depression, fentanyl transdermal system is contraindicated for use as an as-needed analgesic, in non-opioid tolerant patients, in acute pain, and in postoperative pain [see Contraindications (4) and Warnings and Precautions (5.2) ]. (nih.gov)
  • 3,4 During this time, fentanyl and related substances have contributed to a dramatic rise in drug overdose deaths in the United States. (nih.gov)
  • See the impact of fentanyl and other synthetic opioids on drug overdose deaths. (nih.gov)
  • Gladden RM, Martinez P, Seth P. Fentanyl law enforcement submissions and increases in synthetic opioid-involved overdose deaths - 27 States, 2013-2014 . (nih.gov)
  • Deaths due to a fatal overdose of fentanyl have occurred when children and adults were accidentally exposed to fentanyl transdermal system. (nih.gov)
  • According to Wednesday's report , which analyzed death certificates for drug overdose deaths between 2011 and 2016, fentanyl was involved in nearly 29% of all overdose deaths in 2016. (cnn.com)
  • In 2016, 2 in 5 cocaine-related overdose deaths also involved fentanyl. (cnn.com)
  • Fentanyl is so deadly, in the geographic regions where it's been flooding in, deaths soared like we've never seen before," he said. (cnn.com)
  • In states east of the Mississippi River that trend was reversed, with fentanyl the most common drug implicated in overdose deaths in 2017. (go.com)
  • Hedegaard noted that since the report is a one-year snapshot of overdose deaths, it doesn't provide insight into whether fentanyl deaths are rising or falling in the western U.S. (go.com)
  • About two-thirds of those deaths involved synthetic opioids such as fentanyl. (theepochtimes.com)
  • Synthetic opioids such as fentanyl are driving drug overdose deaths in the United States, and it is unlikely this will end soon. (rand.org)
  • Fentanyl deaths have skyrocketed in the past three years in Central Texas and throughout the state and country. (kxan.com)
  • To observe this more than doubling of overdose deaths from fentanyl before the COVID pandemic was a major surprise. (nih.gov)
  • Fentanyl is now the most commonly used drug involved in drug overdoses, according to a new government report. (cnn.com)
  • This week, he's covering the fentanyl crisis, traveling to West Virginia, the state with the most fatal overdoses in the nation per capita. (ktre.com)
  • The overdoses occurred in states including Colorado, Texas, Nebraska, and Florida and Milgram noted that many of the victims had been unaware that they had been ingesting fentanyl. (theepochtimes.com)
  • DENVER - The Denver Sheriff Department said it's launching a Harm Reduction Release Bag program to give people released from custody tools to help prevent fentanyl overdoses. (9news.com)
  • Pharmaceutical fentanyl is a synthetic opioid approved for treating severe pain, typically advanced cancer pain. (cdc.gov)
  • Fentanyl is a powerful synthetic (lab-made) opioid that is FDA-approved to treat severe pain related to surgery or complex pain conditions. (nih.gov)
  • 1,2 Over the past decade, fentanyl that is made and distributed illegally (sometimes called "illicitly manufactured fentanyl") and other illegally made synthetic opioids have been increasingly found in the drug supply. (nih.gov)
  • As part of a wide-ranging federal response to the ongoing addiction and overdose public health crisis , NIDA conducts and supports research to better understand, prevent, and respond to individual and public health impacts related to fentanyl and other synthetic opioids. (nih.gov)
  • This rise is largely driven by illicit fentanyl and other synthetic opioids. (nih.gov)
  • The sprawling industrial city built along the Yangtze River in east-central China is known for its production of chemicals, including the ingredients needed to cook fentanyl and other powerful synthetic opioids. (latimes.com)
  • In a letter to federal, state, and local law enforcement agencies on April 6, DEA administrator Anne Milgram said there had been at least seven mass incidents since January in which a total of 58 people overdosed, and 29 had died due to fentanyl, a synthetic opioid first approved by the Food and Drug Administration (FDA) to treat acute pain but now widely used as a recreational drug. (theepochtimes.com)
  • Federal and local law enforcement arrested Martinez, 31, in February following a search of his home that netted roughly 1,120 pills laced with fentanyl, a powerful synthetic opioid 50 to 100 times more potent than morphine. (kxan.com)
  • Additionally, the opioid overdose crisis is driven in large part by the potent synthetic opioid fentanyl, but few preclinical studies have investigated the processes at work in the brain that lead to addiction relapse when fentanyl is involved. (nih.gov)
  • NIH-supported research highlights fentanyl-containing pills as a growing, dangerous trend, particularly for people new to drug use. (nih.gov)
  • An increase in illicit pills containing fentanyl points to a new and increasingly dangerous period in the United States," said NIDA Director Nora D. Volkow, M.D. "Pills are often taken or snorted by people who are more naïve to drug use, and who have lower tolerances. (nih.gov)
  • Illicitly manufactured powder fentanyl has been a known adulterant in drugs since 2013 , but the extent that fentanyl is found in counterfeit pills has been largely unknown. (nih.gov)
  • Further, people who use these types of pills are less likely to have a tolerance built to opioids, and when coupled with the sedative effects of non-fentanyl opioids or benzodiazepines, may further increase risk of overdose and death. (nih.gov)
  • Fentanyl pills disguised as prescription pain killers. (latimes.com)
  • Milgram said that traffickers are also putting fentanyl in fake prescription pills like OxyContin, Percocet, and Vicodin which are used to treat moderate to severe pain and are widely used among drug abusers. (theepochtimes.com)
  • Mexican cartels reportedly import fentanyl from China before pressing it into pills or mixing it into other narcotics to increase its potency. (theepochtimes.com)
  • Police monitored the purchases, tested the pills and found they contained fentanyl, according to a federal complaint. (kxan.com)
  • Because an estimated 30-40 percent of those tainted pills contain levels of fentanyl that can kill you, it becomes a game of Russian roulette. (nih.gov)
  • 4,7,8 Because fentanyl is about 50 to 100 times more potent than morphine 9,10,11 and a lethal dose of fentanyl can be very small, using a drug that has been contaminated with or replaced by fentanyl can greatly increase one's risk of overdose. (nih.gov)
  • Fentanyl transdermal system should be prescribed only by healthcare professionals who are knowledgeable in the use of potent opioids for the management of chronic pain. (nih.gov)
  • Fentanyl Transdermal System contains a high concentration of a potent Schedule II opioid agonist, fentanyl. (nih.gov)
  • Illicit fentanyl is highly potent, cheaply made and easily transported, making it a profitable narcotic. (nih.gov)
  • Articles on this page explain the fentanyl crisis from multiple angles. (statnews.com)
  • A clearly frustrated Kelowna City Council received an official update on the growing fentanyl crisis in the city Monday, as the Interior Health Authority asked the municipality to assist in possible solutions. (cbc.ca)
  • Despite the regional implications of the report, fentanyl is still driving the nation's opioid crisis. (go.com)
  • We know that harsher criminal penalties have done nothing to address the overdose crisis, which has only gotten exponentially worse since Congress [temporarily scheduled fentanyl-related substances]. (reason.com)
  • The implementation of this program is a reflection of the immediate need there is to save lives because of the fentanyl crisis our nation is experiencing," said Denver Sheriff Elias Diggins. (9news.com)
  • The opioid crisis, which worsened during the pandemic and now involves the scourge of fentanyl, claims more than 70,000 lives each year in the United States [1]. (nih.gov)
  • The results of studies on the effect of epidural fentanyl on breastfeeding initiation and duration are mixed, because of the many different combinations of drugs, dosages and patient populations studied as well as the variety of techniques used and deficient designs of many of the studies. (nih.gov)
  • In infants placed skin-to-skin after a normal vaginal delivery, epidural fentanyl given during labor may delay the infant's first suckling in a dose-dependent manner,[ 4 ] perhaps because it can persist in the infant's serum for over 24 hours after discontinuation. (nih.gov)
  • 5 ] However, it appears that with good breastfeeding support, epidural fentanyl plus bupivacaine has little overall effect on breastfeeding success. (nih.gov)
  • Read patient health information on prescription fentanyl from MedlinePlus. (nih.gov)
  • Serious, life-threatening, or fatal respiratory depression may occur with use of fentanyl transdermal system, even when used as recommended. (nih.gov)
  • Monitor for respiratory depression, especially during initiation of fentanyl transdermal system or following a dose increase. (nih.gov)
  • The concomitant use of fentanyl transdermal system with all cytochrome P450 3A4 inhibitors may result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. (nih.gov)
  • Due to the risk of respiratory depression, fentanyl transdermal system is only indicated for use in patients who are already opioid-tolerant. (nih.gov)
  • Schedule II opioid substances which include fentanyl, hydromorphone, methadone, morphine, oxycodone, and oxymorphone have the highest potential for abuse and associated risk of fatal overdose due to respiratory depression. (nih.gov)
  • Plasma fentanyl levels of 0.2 to 1.2 mcg/L are required for analgesia via the nonepidural route and plasma levels over 1 to 2 mcg/L may cause respiratory depression. (nih.gov)
  • To identify the challenges associated with reversing fentanyl-induced respiratory depression. (nih.gov)
  • Ten women were given 50 to 100 mcg of intravenous fentanyl every hour during labor. (nih.gov)
  • Patients 2 through 6 received intravenous fentanyl within 48 hours before S. paucimobilis bacteremia developed and had isolates with a PFGE pattern indistinguishable from that of fentanyl isolates. (cdc.gov)
  • Patient 1 did not receive intravenous fentanyl and had S. paucimobilis bacteremia with a distinct PFGE pattern. (cdc.gov)
  • Influence of St. John' s Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial. (nih.gov)
  • Fentanyl is structurally different from morphinan-opioids and preferentially partitions into fat-rich tissues such as brain. (nih.gov)
  • It defines an FRS as "any substance that is structurally related to fentanyl" and features one of five chemical alterations. (reason.com)
  • If you stop taking your other pain medication(s) you will need to stop using fentanyl. (medlineplus.gov)
  • Drug traffickers are driving addiction, and increasing their profits, by mixing fentanyl with other illicit drugs. (theepochtimes.com)
  • Do not use a larger dose of fentanyl, use the medication more often, or use it for a longer period of time than prescribed by your doctor. (medlineplus.gov)
  • Patients wearing fentanyl transdermal systems who develop fever or increased core body temperature due to strenuous exertion are also at risk for increased fentanyl exposure and may require an adjustment in the dose of fentanyl transdermal system to avoid overdose and death [see Warnings and Precautions (5.12) ]. (nih.gov)
  • Mock sizing of a potentially lethal dose of Fentanyl, on April 1, 2022. (theepochtimes.com)
  • HIDTA also distinguish between the presence of fentanyl in pill or powder form. (nih.gov)
  • The trafficking of over five kilograms of fentanyl into Wisconsin is troubling, especially when only two milligrams, equivalent to just a few grains of salt, is a potentially lethal dose," John G. McGarry, assistant special agent in charge for Drug Enforcement Administration-Milwaukee District Office, said. (cbsnews.com)
  • That both morphine and fentanyl have been shown to reduce the rate of absorption and delay the antiplatelet effects of dual antiplatelet therapy (DAPT), however, "is a real problem" since it may be responsible for an increased risk of acute stent thrombosis, she noted. (medscape.com)
  • We replicated what was found for morphine with fentanyl, which has wider potential implications, given the widespread use of the latter in our cath labs," McEvoy said, but he added, "It's hard to know what the clinical implications of a 2-hour difference would be, although it's likely there may be some patients exposed to excess risk. (medscape.com)
  • The HALT Fentanyl Act , which the Republican-controlled House of Representatives approved today by a bipartisan 289-133 vote, would permanently add "fentanyl-related substances" (FRS) to Schedule I of the Controlled Substances Act, the most restrictive category. (reason.com)
  • What this means is that, under the HALT Fentanyl Act , a person could be subject to harsh mandatory minimums for distributing harmless substances or even substances that reverse the effects of fentanyl overdose-just so long as those substances exhibit a particular molecular structure. (reason.com)
  • The proposed blanket ban on fentanyl-related substances will probably apply to new chemicals that do not have an established medical benefit, but the ban would not apply to fentanyl. (rand.org)
  • People who purchase counterfeit drugs, such as illicit oxycodone, hydrocodone, or benzodiazepines may be at risk for unintentional exposure to fentanyl, which is associated with increased risk of overdose death. (nih.gov)
  • To evaluate the effects of fetal exposure to fentanyl and the incidence and clinical manifestations of Neonatal Abstinence Syndrome. (nih.gov)
  • There remains a debate regarding whether there is a fentanyl dose -response relationship and whether the duration of exposure is relevant. (bvsalud.org)
  • Since the peak fentanyl concentrations generally occur between 20 and 72 hours of treatment, prescribers should be aware that serious or life threatening hypoventilation may occur, even in opioid-tolerant patients, during the initial application period. (nih.gov)
  • Limited information indicates that transdermal fentanyl in a dosage of 100 mcg/hour results in undetectable fentanyl concentrations in breastmilk. (nih.gov)
  • To study the transition from fentanyl addiction to medications to treat opioid use disorder, including opioid agonist, partial agonist, and antagonist treatments. (nih.gov)
  • The average peak fentanyl level was 0.40 mcg/L and occurred 45 minutes after the dose. (nih.gov)
  • Tragically, many overdose victims have no idea they are ingesting deadly fentanyl, until it's too late. (theepochtimes.com)
  • Indeed, the new study, presented at the recent European Society of Cardiology 2017 Congress , was met with skepticism by European cardiologists, because "they didn't think it was relevant for their care" and "were surprised that any fentanyl was being given for angiography at all," McEvoy said. (medscape.com)
  • NIDA is interested in supporting research to understand the public health impact, clinical characteristics, and treatment of fentanyl addiction and overdose and how they differ from liabilities associated with morphinan-opioids . (nih.gov)
  • NIDA is especially interested in research examining the risks and outcomes of fentanyl addiction and overdose. (nih.gov)
  • However, most recent cases of fentanyl-related harm, overdose, and death in the U.S. are linked to illegally made fentanyl. (cdc.gov)
  • But the two drugs have different pharmacokinetics, with fentanyl being much shorter-acting, so the drug-drug interaction was not a foregone conclusion, he observed. (medscape.com)
  • RESULTS: St. John' s wort did not alter fentanyl pharmacokinetics. (nih.gov)
  • Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects. (nih.gov)
  • When a pill is contaminated with fentanyl, as is now often the case, poisoning can easily occur. (nih.gov)
  • Other reports have suggested that fentanyl users may require higher buprenorphine doses to stabilize patients, and more severe and prolonged Neonatal Abstinence Syndrome (NAS) may occur when fentanyl is involved. (nih.gov)
  • Fentanyl transdermal system can be abused in a manner similar to other opioid agonists, legal or illicit. (nih.gov)
  • Contains fentanyl, a Schedule II controlled substance with abuse liability similar to other opioid analgesics. (nih.gov)
  • Fentanyl transdermal system exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. (nih.gov)
  • Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations, reserve fentanyl transdermal system for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain. (nih.gov)
  • Research is urgently needed to understand the nature, extent, clinical manifestations, and treatment of fentanyl addiction and overdose. (nih.gov)
  • To identify the prevalence and incidence of fentanyl addiction and overdose in the general and special populations. (nih.gov)
  • To examine the risk and protective factors for fentanyl addiction and overdose. (nih.gov)
  • To evaluate the clinical characteristics of fentanyl addiction and overdose and contrast them with those associated with the use of other opioids, particularly among pregnant and postpartum women. (nih.gov)
  • To study the clinical outcomes of fentanyl addiction and overdose treatments and contrast the outcomes of approved treatments in patients with other opioid use disorders. (nih.gov)
  • Fentanyl is highly addictive, found in all 50 states, and drug traffickers are increasingly mixing it with other types of drugs-in powder and pill form-in an effort to drive up addiction and attract repeat buyers," Milgram said. (theepochtimes.com)
  • Understanding the brain processes involved in fentanyl relapse may lead to the development of new treatment strategies for opioid addiction and overdose prevention. (nih.gov)
  • Schug SA, Ting S. Fentanyl formulations in the management of pain: an update . (nih.gov)
  • Fentanyl-associated fatalities among illicit drug users in Wayne County, Michigan (July 2005-May 2006). (cdc.gov)
  • For drug traffickers interested in getting in on the fentanyl business, all roads once led to Wuhan . (latimes.com)
  • But the novel coronavirus that emerged in Wuhan late last year before spreading across the planet has disrupted the fentanyl supply chain, causing a ripple effect that has cut into the profits of Mexican traffickers and driven up street drug prices across the United States. (latimes.com)
  • Overestimating the fentanyl transdermal system dose when converting patients from another opioid medication can result in fatal overdose with the first dose (see DOSAGE AND ADMINISTRATION - Initial Fentanyl Transdermal System Dose Selection ). (nih.gov)
  • The high content of fentanyl in the patches (fentanyl transdermal system) may be a particular target for abuse and diversion. (nih.gov)
  • In 2011, fentanyl was involved in just 4% of all drug fatalities. (cnn.com)
  • Assess each patient's risk prior to prescribing Fentanyl transdermal system, and monitor all patients regularly for the development of these behaviors or conditions [see Warnings and Precautions (5.1) ]. (nih.gov)
  • Monitor patients receiving fentanyl transdermal system and any CYP3A4 inhibitor or inducer [see Warnings and Precautions (5.10) , and Clinical Pharmacology (12.3) ]. (nih.gov)
  • Patients receiving fentanyl transdermal system and any CYP3A4 inhibitor should be carefully monitored for an extended period of time and dosage adjustments should be made if warranted (see CLINICAL PHARMACOLOGY - Drug Interactions , WARNINGS , PRECAUTIONS , and DOSAGE AND ADMINISTRATION for further information). (nih.gov)
  • Fentanyl transdermal system should be administered to children only if they are opioid-tolerant and 2 years of age or older (see PRECAUTIONS - Pediatric Use ). (nih.gov)
  • Before taking Fentanyl Patch , what precautions must I follow? (cgh.com.sg)
  • Fentanyl may cause serious harm or death if used accidentally by a child or by an adult who has not been prescribed the medication. (medlineplus.gov)
  • Such mass events are occurring because drug dealers sell their product to customers marketing it as cocaine when it is actually fentanyl, leading unaware buyers to accidentally overdose. (theepochtimes.com)
  • Learn more about fentanyl from the Drug Enforcement Administration . (nih.gov)
  • Charlie Hodge said he recently lost a relative to a fentanyl overdose and he fears for another relative who is a drug user. (cbc.ca)
  • The coronavirus is dealing a blow to the illegal drug trade, disrupting supply chains in China of chemicals used to make such drugs as fentanyl. (latimes.com)
  • Turner has also started the nonprofit organization Texas Against Fentanyl , which welcomes families who have also suffered the same fate and spreads awareness about the deadly drug. (kvue.com)
  • CHULA VISTA, Calif. (KGTV) - Federal and local authorities, in addition to hazmat crews, were called out to the scene of a drug raid in Chula Vista after agents found fentanyl and THC extraction on the property. (10news.com)
  • The Drug Enforcement Administration (DEA) has warned of a surge in mass overdose events involving fentanyl, a highly addictive and deadly drug, across the United States, stating that the drug is killing Americans at an "unprecedented" rate. (theepochtimes.com)
  • This is creating a frightening trend where many overdose victims are dying after unknowingly ingesting fentanyl," Milgram said, adding that the DEA is working to trace mass overdose events involving fentanyl back to the drug organizations responsible for an increase in domestic supply of the opioid. (theepochtimes.com)
  • Authorities arrested 35 people and seized enough fentanyl to kill roughly 14 million people in a three-state drug bust announced on Thursday by the US Justice Department. (cnn.com)
  • The alleged drug trafficking ring is an example of fentanyl coming to the US from China, said US Attorney G. Zachary Terwilliger of the Eastern District of Virginia. (cnn.com)
  • After two weeks of choosing food over fentanyl, the animals subsequently resumed using fentanyl when they no longer had access to their preferred food, a situation resembling drug relapse in humans. (nih.gov)
  • The study also found an increase in the number of fentanyl-containing powder seizures during this time. (nih.gov)
  • Seizures of powder containing fentanyl also increased from 424 to 1,539, and the total weight of powder seized increased from 298.2 kg to 2,416.0 kg. (nih.gov)
  • Fentanyl is metabolized to norfentanyl and inactive metabolites. (nih.gov)
  • Individuals released from the Downtown Detention Center and Denver County Jail will be given bags that include one dose of Narcan and five fentanyl test strips. (9news.com)
  • We want to ensure that everyone who would like Narcan, fentanyl test strips and MAT resources have them upon release to the community," said Dr. Nikki Johnson, chief of mental health services for the sheriff department. (9news.com)
  • When used epidurally or intravenously during labor or for a short time immediately postpartum, amounts of fentanyl ingested by the neonate are usually small and are not expected to cause any adverse effects in breastfed infants. (nih.gov)
  • Thirteen women were given a single fentanyl 2 mcg/kg intravenous dose during either cesarean section or postpartum tubal ligation. (nih.gov)
  • To evaluate the safety and efficacy of pharmacological treatments in pregnant and postpartum women addicted to fentanyl. (nih.gov)