3-Oxoacyl-(Acyl-Carrier-Protein) Synthase: An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. EC 2.3.1.41.Acyl Carrier Protein: Consists of a polypeptide chain and 4'-phosphopantetheine linked to a serine residue by a phosphodiester bond. Acyl groups are bound as thiol esters to the pantothenyl group. Acyl carrier protein is involved in every step of fatty acid synthesis by the cytoplasmic system.Transferases (Other Substituted Phosphate Groups): A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.Cerulenin: An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.Pantetheine: An intermediate in the pathway of coenzyme A formation in mammalian liver and some microorganisms.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Fatty Acid Synthases: Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives.Acyltransferases: Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Fatty Acid Synthase, Type II: The form of fatty acid synthase complex found in BACTERIA; FUNGI; and PLANTS. Catalytic steps are like the animal form but the protein structure is different with dissociated enzymes encoded by separate genes. It is a target of some ANTI-INFECTIVE AGENTS which result in disruption of the CELL MEMBRANE and CELL WALL.ThiophenesPolyketide Synthases: Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Acyl-Carrier Protein S-Malonyltransferase: This enzyme catalyzes the transacylation of malonate from MALONYL CoA to activated holo-ACP, to generate malonyl-(acyl-carrier protein), which is an elongation substrate in FATTY ACIDS biosynthesis. It is an essential enzyme in the biosynthesis of FATTY ACIDS in all BACTERIA.3-Oxoacyl-(Acyl-Carrier-Protein) Reductase: A 3-oxoacyl reductase that has specificity for ACYL CARRIER PROTEIN-derived FATTY ACIDS.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Coenzyme ABacterial Proteins: Proteins found in any species of bacterium.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Pantothenic Acid: A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Enoyl-(Acyl-Carrier-Protein) Reductase (NADH): An NAD-dependent enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein]. It has a preference for acyl groups with a carbon chain length between 4 to 16.Genetic Complementation Test: A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.Carbon-Sulfur Ligases: Enzymes that catalyze the joining of two molecules by the formation of a carbon-sulfur bond. EC 6.2.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Acylation: The addition of an organic acid radical into a molecule.Malonyl Coenzyme A: A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.Thiolester HydrolasesIsoenzymes: Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.Triclosan: A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.Acyl Coenzyme A: S-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation.Streptomyces: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.Saccharopolyspora: A genus of gram-positive bacteria whose spores are round to oval and covered by a sheath.Apoproteins: The protein components of a number of complexes, such as enzymes (APOENZYMES), ferritin (APOFERRITINS), or lipoproteins (APOLIPOPROTEINS).Multienzyme Complexes: Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.Anthraquinones: Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.Coriandrum: A plant genus of the family APIACEAE. The leaves are the source of cilantro and the seeds are the source of coriander, both of which are used in SPICES.Acyl-Carrier Protein S-Acetyltransferase: A enzyme that catalyzes the transfer of acetyl groups from ACETYL CoA to acyl-carrier protein to form COENZYME A and acetyl-acyl-carrier protein.Kinetics: The rate dynamics in chemical or physical systems.MalonatesThioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.Lipid A: Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.Peptide Synthases: Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups.Naphthacenes: Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Plants: Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
... activity. • myristoyl-[acyl-carrier-protein hydrolase activity]. • enoyl-[acyl-carrier-protein reductase ( ... acyl-carrier-protein synthase activity]. • acyl-[acyl-carrier-protein hydrolase activity]. • hydrolase activity. • palmitoyl-[ ... acyl-carrier-protein dehydratase activity]. • protein homodimerization activity. • catalytic activity. • [acyl-carrier-protein ... "Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase". J. Am. Chem. Soc. 132 (35): ...
"Beta-ketoacyl-acyl carrier protein synthase II of Escherichia coli Evidence for function in the thermal regulation of fatty ... acyl-carrier-protein] Thus, the two substrates of this enzyme are (Z)-hexadec-11-enoyl-[acyl-carrier-protein] and malonyl-[acyl ... The systematic name of this enzyme class is (Z)-hexadec-11-enoyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-pr otein] C- ... acyl-carrier-protein], CO2, and acyl-carrier-protein. This enzyme belongs to the family of transferases, specifically those ...
... acyl-carrier-protein) synthase MeSH D08.811.913.050.625 --- phosphatidylcholine-sterol O-acyltransferase MeSH D08.811.913.050. ... fatty acid desaturases MeSH D08.811.682.690.708.392.312 --- beta-carotene 15,15'-monooxygenase MeSH D08.811.682.690.708.392.468 ... acyl-carrier-protein) reductase (nadh) MeSH D08.811.682.660.390 --- enoyl-(acyl-carrier protein) reductase (nadph, b-specific) ... acyl-carrier protein s-acetyltransferase MeSH D08.811.913.050.134.060 --- acetyl-CoA C-acetyltransferase MeSH D08.811.913.050. ...
... acyl-carrier-protein) synthase II EC 2.3.1.180: beta-ketoacyl-(acyl-carrier-protein) synthase III EC 2.3.1.181: lipoyl(octanoyl ... fatty-acid synthase EC 2.3.1.86: fatty-acyl-CoA synthase EC 2.3.1.87: aralkylamine N-acetyltransferase EC 2.3.1.88: peptide a-N ... acyl-carrier-protein) S-acetyltransferase EC 2.3.1.39: (acyl-carrier-protein) S-malonyltransferase EC 2.3.1.40: acyl-(acyl- ... acyl-carrier protein) synthase EC 2.7.7.67: CDP-archaeol synthase EC 2.7.7.68: 2-phospho-L-lactate guanylyltransferase EC 2.7. ...
"Enhanced production of branched-chain fatty acids by replacing β-ketoacyl-(acyl-carrier-protein) synthase III (FabH)". ... "Regulating effect of β-ketoacyl synthase domain of fatty acid synthase on fatty acyl chain length in de novo fatty acid ... "Enhanced production of branched-chain fatty acids by replacing β-ketoacyl-(acyl-carrier-protein) synthase III (FabH)". ... and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli". Journal of Biological ...
fatty acid synthase activity. • myristoyl-[acyl-carrier-protein hydrolase activity]. • enoyl-[acyl-carrier-protein reductase ( ... acyl-carrier-protein synthase activity]. • acyl-[acyl-carrier-protein hydrolase activity]. • hydrolase activity. • palmitoyl-[ ... acyl-carrier-protein dehydratase activity]. • protein homodimerization activity. • catalytic activity. • [acyl-carrier-protein ... identical protein binding. • oleoyl-[acyl-carrier-protein hydrolase activity]. • oxidoreductase activity. • 3-oxoacyl-[ ...
... fatty acid condensing enzyme, acyl-malonyl(acyl-carrier-protein)-condensing enzyme, acyl-malonyl acyl carrier protein- ... acyl-carrier-protein Thus, the two substrates of this enzyme are acyl-acyl-carrier-protein and malonyl-acyl-carrier-protein, ... The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase ( ... beta-ketoacyl-acyl carrier protein synthetase, beta-ketoacyl-[acyl carrier protein] synthase, beta-ketoacylsynthase, condensing ...
... acyl-carrier protein] In Escherichia coli, for example, this enzyme is used to construct fatty acyl chains through a three step ... The reaction proceeds as such: acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] → a 3-oxoacyl-[acyl-carrier ... acyl-carrier protein] + CO2 + [acyl-carrier protein In Streptococcus pneumonia, for example, synthase II is used as an ... The reaction proceeds as such: (Z)-hexadec-11-enoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] → (Z)-3-oxooctadec- ...
... acyl-(acyl-carrier-protein) desaturase EC 1.14.19.3: linoleoyl-CoA desaturase EC 1.14.19.4: Delta8-fatty-acid desaturase EC ... pyruvate synthase EC 1.2.7.2: 2-oxobutyrate synthase EC 1.2.7.3: 2-oxoglutarate synthase EC 1.2.7.4: carbon-monoxide ... acyl-carrier-protein) reductase (NADH) EC 1.3.1.10: enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) EC 1.3.1.11: 2- ... long-chain acyl-(acyl-carrier-protein) reductase EC 1.2.1.81: sulfoacetaldehyde dehydrogenase (acylating) EC 1.2.1.82: beta-apo ...
enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) Ja 1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Ja ... long-chain-fatty-acyl-CoA reductase Ja 1.2.3.1 aldehyde oxidase Ja ... pyridoxal 5'-phosphate synthase Ja 1.4.3.13 protein-lysine 6-oxidase Ja ... Glycerol-3-fosfaatdehydrogenase (NAD+) Ja 1.1.1.9 Xylitol + NAD+ ⇌. {\displaystyle \rightleftharpoons }. D-xylulose + NADH + H+ ...
Price AC, Choi KH, Heath RJ, Li Z, White SW, Rock CO (March 2001). "Inhibition of beta-ketoacyl-acyl carrier protein synthases ... The formation of a carbon-carbon bond is a key step in the biosynthetic pathways by which fatty acids and polyketide are made. ... Middleton B (April 1973). "The oxoacyl-coenzyme A thiolases of animal tissues". Biochem. J. 132 (4): 717-30. PMC 1177647 . PMID ... Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to ...
Fatty acid synthesis/. Fatty acid synthase. *Beta-ketoacyl-ACP synthase. *Β-Ketoacyl ACP reductase ... acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase ... Other names in common use include beta-ketoacyl-[acyl-carrier protein](ACP) reductase, beta-ketoacyl acyl carrier protein (ACP ... Prescott DJ, Vagelos PR (1972). "Acyl carrier protein". Adv. Enzymol. Relat. Areas Mol. Biol. 36: 269-311. doi:10.1002/ ...
Fatty acid synthesis/. Fatty acid synthase. *Beta-ketoacyl-ACP synthase. *Β-Ketoacyl ACP reductase ... acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase ... Other names in common use include beta-ketoacyl-[acyl-carrier protein](ACP) reductase, beta-ketoacyl acyl carrier protein (ACP ... Prescott DJ, Vagelos PR (1972). "Acyl carrier protein". Adv. Enzymol. Relat. Areas Mol. Biol. 36: 269-311. doi:10.1002/ ...
Several fatty acid metabolic pathways such as linoleic acid metabolism and glycerolipid metabolism were involved. All these ... Several fatty acid metabolic pathways such as linoleic acid metabolism and glycerolipid metabolism were involved. All these ... acyl-carrier-protein] synthase II (FabF; [EC:2.3.1.179]) and 3-oxoacyl-[acyl-carrier protein] reductase (FabG; [EC:1.1.1.100 ... such as sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase, and acetyl-CoA carboxylase in the liver (Kim ...
Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the ... total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate ... Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP ... specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids. ...
... acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl ... acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl ... acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl ... Edges represent protein-protein associations. associations are meant to be specific and meaningful, i.e. proteins jointly ...
... acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl ... acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl ... acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl ... acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl ...
... acyl carrier protein) synthase III gene located in the glycosylation island of Pseudomonas syringae pv. tabaci regulates ... virulence factors via N-acyl homoserine lactone and fatty acid synthesis Author. Taguchi, Fumiko, Ogawa, Yujiro, Takeuchi, ... J_ClinMicrobiol_51_3_1040.pdf Author. Naha, A., Chowdhury, G., Ghosh-Banerjee, J., Senoh, M., Takahashi, T., Ley, B., Thriemer ... J_ClinMicrobiol_52_3_1020.pdf Author. Ghosh, Priyanka, Naha, Arindam, Basak, Surajit, Ghosh, Santanu, Ramamurthy, T., Koley, ...
MetabolismFatty acid and phospholipid metabolismBiosynthesisbeta-ketoacyl-acyl-carrier-protein synthase II (TIGR03150; EC 2.3. ... acyl-carrier-protein] synthase III (TIGR00747; EC 2.3.1.180; HMM-score: 16.8) ... acyl-carrier-protein (ACP)] synthase III C terminal (PF08541; HMM-score: 12.5) ... Fatty Acids, Lipids, and IsoprenoidsFatty Acids, Lipids, and Isoprenoids - no subcategoryPolyhydroxybutyrate metabolism 3- ...
MetabolismFatty acid and phospholipid metabolismBiosynthesisbeta-ketoacyl-acyl-carrier-protein synthase II (TIGR03150; EC 2.3. ... acyl-carrier-protein] synthase III (TIGR00747; EC 2.3.1.180; HMM-score: 16.8) ... Fatty Acids, Lipids, and IsoprenoidsFatty Acids, Lipids, and Isoprenoids - no subcategoryPolyhydroxybutyrate metabolism 3- ... FAE1_CUT1_RppA; FAE1/Type III polyketide synthase-like protein (PF08392; HMM-score: 12) ...
beta-ketoacyl-acyl-carrier-protein synthase II. KO. K09458 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]. ... Fatty acid biosynthesis. 00780 Biotin metabolism. 01100 Metabolic pathways. 01212 Fatty acid metabolism. ...
... acyl-carrier-protein] synthase, KASIII (EC 2.3.1.180). and 1 more. Fatty Acids, Lipids, and IsoprenoidsFatty acidsFatty Acid ... Beta-ketoacyl-[acyl-carrier-protein] synthase IAcyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl- ... acyl-carrier-protein] synthase IIIAcetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2 ... acyl-carrier-protein (ACP)] synthase III (PF08545; HMM-score: 98) Thiolase_N; Thiolase, N-terminal domain (PF00108; HMM-score: ...
... acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p. ... Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not ... Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian ... Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating ...
... acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl ... Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis ... Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis ... Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis ...
... acyl-carrier-protein] synthase activity,fatty acid synthase activity,3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) ... acyl-carrier-protein] dehydratase activity,[acyl-carrier-protein] S-acetyltransferase activity,[acyl-carrier-protein] S- ... beta-ketoacyl synthase and self-pantetheinylation activities fatty acid biosynthetic process holo-[acyl-carrier-protein] ... acyl-carrier-protein] reductase (NADPH, B-specific) activity,fatty acid synthase activity,3-hydroxyacyl-[ ...
Acyl-carrier-protein] acetyl transferase of FASI (EC 2.3.1.38) / Enoyl-[acyl-carrier-protein] reductase of FASI (EC 1.3.1.9) / ... acyl-carrier-protein] dehydratase of FASI (EC 4.2.1.61) / [Acyl-carrier-protein] malonyl transferase of FASI (EC 2.3.1.39) / [ ... Acyl-carrier-protein] palmitoyl transferase of FASI (EC 2.3.1.-) / Acyl carrier protein of FASI / 3-oxoacyl-[acyl-carrier- ... acyl-carrier-protein] synthase of FASI (EC 2.3.1.41). Rv2382c. ... protein] reductase of FASI (EC 1.1.1.100) / 3-oxoacyl-[ ...
Beta-ketoacyl-acyl-carrier-protein synthase I - In enzymology, a beta ketoacyl acyl carrier protein synthase I (EC number,2.3. ... as steps in fatty acid synthesis; Cys protein is also a part of the fatty acid synthase complex. SYN:… … Medical dictionary ... Beta-ketoacyl-acyl-carrier-protein synthase II - In enzymology, a beta ketoacyl acyl carrier protein synthase II (EC number,2.3 ... Beta-ketoacyl-(acyl-carrier-protein) synthase III - In enzymology, a beta ketoacyl [acyl carrier protein] synthase III (EC ...
... acyl-carrier-protein) synthase; Belongs to the beta-ketoacyl-ACP synthases family ... Membrane protein; Predicted exporter. AMP-ligase; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases ... acyl-carrier-protein) synthase; Belongs to the beta-ketoacyl-ACP synthases family ... acyl-carrier-protein) synthase; Belongs to the beta-ketoacyl-ACP synthases family ...
... acyl-carrier-protein] synthase activity [ISA]. Gene Ontology Cellular Component. *mitochondrion [IDA] ... fatty acid synthase CEM1, L000000292, YER061C. Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; ... fatty acid biosynthetic process [ISA]. Gene Ontology Molecular Function. *3-oxoacyl-[ ... MYND domain-containing protein; required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly ...
Acyl-Carrier-Protein) Reductase .. D08.811.682.047.820.196.500 Fatty Acid Synthases .. D08.811.682.047.820.196.500.099 Fatty ... Fatty Acid Synthase, Type I .. Fatty Acid Synthase, Animal Form .. Fatty Acid Synthase, Mammalian .. Fatty Acid Synthetase ... D08.811.913.050.134.029 Acyl-Carrier Protein S-Acetyltransferase .. D08.811.913.050.134.029.500 Fatty Acid Synthases .. D08.811 ... D08.811.913.050.170 Acyl-Carrier Protein S-Malonyltransferase .. D08.811.913.050.170.500 Fatty Acid Synthases .. D08.811. ...
01004 Lipid biosynthesis proteins [BR:hsa01004] 2194 FASN; fatty acid synthase 27349 MCAT; malonyl-CoA-acyl carrier protein ... K00665 FASN; fatty acid synthase, animal type [EC:2.3.1.85] K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3. ... 8540 AGPS; alkylglycerone phosphate synthase 55711 FAR2; fatty acyl-CoA reductase 2 84188 FAR1; fatty acyl-CoA reductase 1 4598 ... medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21] K01074 PPT; palmitoyl-protein thioesterase [EC:3.1.2.22] ...
... acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl ... Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein ( ... Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein ( ... Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein ( ...
Cyclopropropane fatty acyl-phospholipid synthase. 0481. 0465c. DNA-binding protein, putative. 0583. 0557. Glycosyl transferase ... Acyl carrier protein. 2303. 2243. Malonyl CoA-acyl carrier protein. 0311. 0297. PE-PGRS 5. ... foIP1, dihydropteroate synthase 1. *. ↵ a CHP, conserved hypothetical protein, with additional annotation derived from the ... a Abbreviations: HP, hypothetical proteins; CHP, conserved hypothetical proteins; OD, optical density. ...
Beta-ketoacyl acyl carrier protein reductase (FabG) activity of the fatty acid biosynthetic pathway is a determining factor of ... Inhibition of beta-ketoacyl-acyl carrier protein synthase III (FabH) by acyl-acyl carrier protein in Escherichia coli. J. Biol ... The intrinsic specificity of the AHL synthase for subsets of acyl-acyl carrier protein (acyl-ACP) substrates is an important ... AHLs are produced from acylated acyl-carrier protein (acyl-ACP) and S-adenosyl-l-methionine by the AHL synthase enzyme. The ...
... acyl-carrier-protein] synthase activity,fatty acid synthase activity,3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) ... acyl-carrier-protein] dehydratase activity,[acyl-carrier-protein] S-acetyltransferase activity,[acyl-carrier-protein] S- ... beta-ketoacyl synthase and self-pantetheinylation activities fatty acid biosynthetic process holo-[acyl-carrier-protein] ... acyl-carrier-protein] reductase (NADPH, B-specific) activity,fatty acid synthase activity,3-hydroxyacyl-[ ...
... acyl-carrier-protein] synthase activity,fatty acid synthase activity,3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) ... acyl-carrier-protein] dehydratase activity,[acyl-carrier-protein] S-acetyltransferase activity,[acyl-carrier-protein] S- ... beta-ketoacyl synthase and self-pantetheinylation activities fatty acid biosynthetic process holo-[acyl-carrier-protein] ... acyl-carrier-protein] reductase (NADPH, B-specific) activity,fatty acid synthase activity,3-hydroxyacyl-[ ...
... acyl-carrier-protein] synthase activity,fatty acid synthase activity,3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) ... acyl-carrier-protein] dehydratase activity,[acyl-carrier-protein] S-acetyltransferase activity,[acyl-carrier-protein] S- ... beta-ketoacyl synthase and self-pantetheinylation activities fatty acid biosynthetic process holo-[acyl-carrier-protein] ... acyl-carrier-protein] reductase (NADPH, B-specific) activity,fatty acid synthase activity,3-hydroxyacyl-[ ...
... acyl-carrier-protein] synthase activity,fatty acid synthase activity,3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) ... acyl-carrier-protein] dehydratase activity,[acyl-carrier-protein] S-acetyltransferase activity,[acyl-carrier-protein] S- ... beta-ketoacyl synthase and self-pantetheinylation activities fatty acid biosynthetic process holo-[acyl-carrier-protein] ... acyl-carrier-protein] reductase (NADPH, B-specific) activity,fatty acid synthase activity,3-hydroxyacyl-[ ...
  • The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. (scbt.com)
  • Insulin, glucose and AICAR (an activator of AMP-activated protein kinase) affected changes in hypothalamic FAS mRNA, which may be regulated via the SREBP1c dependent or independent pathway. (pku.edu.cn)
  • Pathway analysis revealed 24 co-expressed transcripts involved in lipid biosynthesis and fatty acid biosynthesis pathways. (biomedcentral.com)
  • Geiger's group discovered the phosphatidylcholine synthase pathway, which constitutes a major route for phosphatidylcholine (lecithin) formation in bacteria as well as the biosynthesis pathway for ornithine-containing lipids, which are widespread bioactive lipids encountered in bacterial membranes. (unam.mx)
  • propionyl-CoA carboxylase with a carboxylase derived from Streptomyces coelicolor resulted in angelyl-CoA levels up to 6.4 mg/L. In vivo analysis allowed identification of important intermediates in the pathway, including methyl-malonyl-CoA and 3-hydroxyl-2-methyl-butyryl-CoA. (biomedcentral.com)
  • Ct 's major active pathways are glycolysis, gluconeogenesis, glycerol-phospholipid (GPL) biosynthesis (support from host acetyl-CoA) and pentose phosphate pathway (PPP), while its incomplete TCA and fatty acid biosynthesis are less active. (frontiersin.org)
  • Consistent with the findings that peroxisomes are formed in the Endoplasmic Reticulum, we find that the most universally conserved Peroxisome biogenesis and maintenance proteins are homologous to proteins from the Endoplasmic Reticulum Assisted Decay pathway. (beds.ac.uk)
  • Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids. (go.jp)
  • NADP serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (hmdb.ca)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • This analysis of the sequence supports the view that the erythromycin-producing polyketide synthase contains three multienzyme polypeptides, each of which accomplishes two successive cycles of polyketide chain extension. (nih.gov)
  • We describe several protein sequence statistics designed to evaluate distinctive attributes of residue content and arrangement in primary structure. (oaji.net)
  • The computer program SEQUANA (statistical analysis of protein sequences) calculates all the statistics for any individual protein sequence input and is available for the WINDOWS environment through electronic mail on request to [email protected] (oaji.net)
  • 119, Last updated, Version 3) XX DE Rhodococcus jostii RHA1 plasmid pRHL3, complete sequence. (univ-lyon1.fr)
  • We report that FabR bound the intact promoter regions of both fabA and fabB in the absence of unsaturated acyl thioesters, but bound the two promoters differently. (nih.gov)
  • However, in contrast to E. coli, gel mobility shift assays indicated that neither E. coli nor V. cholerae FabRs bound the V. cholerae fabB promoter, although both proteins efficiently bound the V. cholerae fabA promoter. (nih.gov)
  • Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common . (jcvi.org)
  • However, this bacterium uses one of the FabZ homologues (now called FabN) and one of the FabF homologues (now called FabO) to perform the unsaturated fatty acid synthetic functions performed by E. coli FabA and FabB [ 9 , 10 ]. (beds.ac.uk)
  • The growing fatty acid chain is carried between these active sites while attached covalently to the phosphopantetheine prosthetic group of an acyl carrier protein (ACP), and is released by the action of a thioesterase (TE) upon reaching a carbon chain length of 16 (palmitic acid). (wikipedia.org)
  • The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. (smpdb.ca)
  • Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases. (genome.jp)
  • Entrance of an acyl-CoA substrate through the solvent portal would require energetically unfavorable reptational threading of the substrate to its reactive position. (rcsb.org)
  • Hence, it would be important to study mtFabD function in a situation where these formal protein-protein interactions are altered or nonexistent, such as in yeast mitochondrial FASII. (hindawi.com)
  • Global analysis of protein localization in budding yeast. (ymdb.ca)
  • Bagnat M, Simons K: Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae. (smpdb.ca)
  • Gaigg B, Toulmay A, Schneiter R: Very long-chain fatty acid-containing lipids rather than sphingolipids per se are required for raft association and stable surface transport of newly synthesized plasma membrane ATPase in yeast. (smpdb.ca)
  • Jones JM, Nau K, Geraghty MT, Erdmann R, Gould SJ: Identification of peroxisomal acyl-CoA thioesterases in yeast and humans. (smpdb.ca)
  • Despite the identification of several key adherence factors, including pneumococcal surface adhesin A (PsaA), pneumococcal serine repeat protein (PsrP), choline binding proteins (CbpA, CbpE), pilus protein (RrgA), plasminogen- and fibronectin-binding proteins (PfbA and PfbB), pneumococcal adherence and virulence factor A and B (PavA and PavB) [ 8 - 15 ], our understanding of the molecular mechanisms of pneumococcal adherence and invasion remains incomplete. (cdc.gov)