Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.Muscle Fatigue: A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.Fatigue Syndrome, Chronic: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)Mental Fatigue: A condition of low alertness or cognitive impairment, usually associated with prolonged mental activities or stress.Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Isometric Contraction: Muscular contractions characterized by increase in tension without change in length.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Physical Endurance: The time span between the beginning of physical activity by an individual and the termination because of exhaustion.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Sleep Disorders: Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)Fibromyalgia: A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)Electromyography: Recording of the changes in electric potential of muscle by means of surface or needle electrodes.Asthenopia: Term generally used to describe complaints related to refractive error, ocular muscle imbalance, including pain or aching around the eyes, burning and itchiness of the eyelids, ocular fatigue, and headaches.Depression: Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Torque: The rotational force about an axis that is equal to the product of a force times the distance from the axis where the force is applied.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Exercise: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Diaphragm: The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.Muscle Strength: The amount of force generated by MUSCLE CONTRACTION. Muscle strength can be measured during isometric, isotonic, or isokinetic contraction, either manually or using a device such as a MUSCLE STRENGTH DYNAMOMETER.Physical Exertion: Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.Postpoliomyelitis Syndrome: A syndrome characterized by new neuromuscular symptoms that occur at least 15 years after clinical stability has been attained in patients with a prior history of symptomatic poliomyelitis. Clinical features include new muscular weakness and atrophy of the limbs, bulbar innervated musculature, and muscles of respiration, combined with excessive fatigue, joint pain, and reduced stamina. The process is marked by slow progression and periods of stabilization. (From Ann NY Acad Sci 1995 May 25;753:68-80)Electric Stimulation: Use of electric potential or currents to elicit biological responses.Neurasthenia: A mental disorder characterized by chronic fatigue and concomitant physiologic symptoms.Work Schedule Tolerance: Physiological or psychological effects of periods of work which may be fixed or flexible such as flexitime, work shifts, and rotating shifts.Survivors: Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.Quadriceps Muscle: The quadriceps femoris. A collective name of the four-headed skeletal muscle of the thigh, comprised of the rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis.Sleep: A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)Materials Testing: The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.Fractures, Stress: Fractures due to the strain caused by repetitive exercise. They are thought to arise from a combination of MUSCLE FATIGUE and bone failure, and occur in situations where BONE REMODELING predominates over repair. The most common sites of stress fractures are the METATARSUS; FIBULA; TIBIA; and FEMORAL NECK.Anxiety: Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.Knee: A region of the lower extremity immediately surrounding and including the KNEE JOINT.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Exercise Therapy: A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Disorders of Excessive Somnolence: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Activities of Daily Living: The performance of the basic activities of self care, such as dressing, ambulation, or eating.Exercise Tolerance: The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Reflex, Acoustic: Intra-aural contraction of tensor tympani and stapedius in response to sound.Sound: A type of non-ionizing radiation in which energy is transmitted through solid, liquid, or gas as compression waves. Sound (acoustic or sonic) radiation with frequencies above the audible range is classified as ultrasonic. Sound radiation below the audible range is classified as infrasonic.Ear Canal: The narrow passage way that conducts the sound collected by the EAR AURICLE to the TYMPANIC MEMBRANE.Reflex: An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.Oscillometry: The measurement of frequency or oscillation changes.

Perioperative growth hormone treatment and functional outcome after major abdominal surgery: a randomized, double-blind, controlled study. (1/2703)

OBJECTIVE: To evaluate short- and long-term effects of perioperative human growth hormone (hGH) treatment on physical performance and fatigue in younger patients undergoing a major abdominal operation in a normal postoperative regimen with oral nutrition. SUMMARY BACKGROUND DATA: Muscle wasting and functional impairment follow major abdominal surgery. METHODS: Twenty-four patients with ulcerative colitis undergoing ileoanal J-pouch surgery were randomized to hGH (12 IU/day) or placebo treatment from 2 days before to 7 days after surgery. Measurements were performed 2 days before and 10, 30, and 90 days after surgery. RESULTS: The total muscle strength of four limb muscle groups was reduced by 7.6% in the hGH group and by 17.1% in the placebo group at postoperative day 10 compared with baseline values. There was also a significant difference between treatment groups in total muscle strength at day 30, and at the 90-day follow-up total muscle strength was equal to baseline values in the hGH group, but still significantly 5.9% below in the placebo group. The work capacity decreased by approximately 20% at day 10 after surgery, with no significant difference between treatment groups. Both groups were equally fatigued at day 10 after surgery, but at day 30 and 90 the hGH patients were less fatigued than the placebo patients. During the treatment period, patients receiving hGH had reduced loss of limb lean tissue mass, and 3 months after surgery the hGH patients had regained more lean tissue mass than placebo patients. CONCLUSIONS: Perioperative hGH treatment of younger patients undergoing major abdominal surgery preserved limb lean tissue mass, increased postoperative muscular strength, and reduced long-term postoperative fatigue.  (+info)

Carbon disulphide absorption during xanthate reagent mixing in a gold mine concentrator. (2/2703)

A xanthate reagent mixer at a gold mine concentrator was exposed to carbon disulphide by extensive skin contamination with xanthate powder and solution during the reagent mixing process. Absorption of carbon disulphide was confirmed by the detection of urinary 2-thiothiazolidine-4-carboxylic acid (TTCA). Drager colorimetric tube testing during subsequent mixing recorded a maximum concentration of at least 60 ppm carbon disulphide. An illness consisting of predominantly gastrointestinal symptoms began 20 h after the exposure. Although this may have been due to carbon disulphide toxicity this is by no means certain. The need for engineering controls, impervious protective clothing and full-face respirators with particulate and organic vapour cartridges is discussed. This episode occurred at another mine site, unrelated to Mount Isa Mines Limited.  (+info)

The role of capsaicin-sensitive muscle afferents in fatigue-induced modulation of the monosynaptic reflex in the rat. (3/2703)

1. The role of group III and IV afferent fibres of the lateral gastrocnemious muscle (LG) in modulating the homonymous monosynaptic reflex was investigated during muscle fatigue in spinalized rats. 2. Muscle fatigue was induced by a series of increasing tetanic electrical stimuli (85 Hz, 600 ms) delivered to the LG muscle nerve. Series consisted of increasing train numbers from 1 to 60. 3. Potentials from the spinal cord LG motor pool and from the ventral root were recorded in response to proprioceptive afferent stimulation and analysed before and during tetanic muscle activations. Both the pre- and postsynaptic waves showed an initial enhancement and, after a '12-train' series, an increasing inhibition. 4. The enhancement of the responses to muscle fatiguing stimulation disappeared after L3-L6 dorsal root section, while a partial reflex inhibition was still present. Conversely, after section of the corresponding ventral root, there was only a reduction in the inhibitory effect. 5. The monosynaptic reflex was also studied in animals in which a large number of group III and IV muscle afferents were eliminated by injecting capsaicin (10 mM) into the LG muscle. As a result of capsaicin treatment, the fatigue-induced inhibition of the pre- and postsynaptic waves disappeared, while the response enhancement remained. 6. We concluded that the monosynaptic reflex inhibition, but not the enhancement, was mediated by those group III and IV muscle afferents that are sensitive to the toxic action of capsaicin. The afferents that are responsible for the response enhancement enter the spinal cord through the dorsal root, while those responsible for the inhibition enter the spinal cord through both the ventral and dorsal roots.  (+info)

Effect of working hours on cardiovascular-autonomic nervous functions in engineers in an electronics manufacturing company. (4/2703)

A field survey of 147 engineers (23-49 years) in an electronics manufacturing company was conducted to investigate the effect of working hours on cardiovascular-autonomic nervous functions (urinary catecholamines, heart rate variability and blood pressure). The subjects were divided into 3 groups by age: 23-29 (n = 49), 30-39 (n = 74) and 40-49 (n = 24) year groups. Subjects in each age group were further divided into shorter (SWH) and longer (LWH) working hour subgroups according to the median of weekly working hours. In the 30-39 year group, urinary noradrenaline in the afternoon for LWH was significantly lower than that for SWH and a similar tendency was found in the LF/HF ratio of heart rate variability at rest. Because these two autonomic nervous indices are related to sympathetic nervous activity, the findings suggested that sympathetic nervous activity for LWH was lower than that for SWH in the 30-39 year group. Furthermore, there were significant relationships both between long working hours and short sleeping hours, and between short sleeping hours and high complaint rates of "drowsiness and dullness" in the morning in this age group. Summarizing these results, it appeared that long working hours might lower sympathetic nervous activity due to chronic sleep deprivation.  (+info)

Investigating fatigue of less than 6 months' duration. Guidelines for family physicians. (5/2703)

OBJECTIVE: To develop an evidence-based systematic approach to assessment of adult patients who present to family physicians complaining of fatigue of less than 6 months' duration. The guidelines present investigative options, making explicit what should be considered in all cases and what should be considered only in specific situations. They aim to provide physicians with an approach that, to the extent possible, is based on evidence so that time and cost are minimized and detection and management of the cause of the fatigue are optimized. QUALITY OF EVIDENCE: MEDLINE was searched from 1966 to 1997 using the key words "family practice" and "fatigue." Articles about chronic fatigue syndrome were excluded. Articles with level 3 evidence were found, but no randomized trials, cohort studies, or case-control studies were found. Articles looking specifically at the epidemiology, demographics, investigations, and diagnoses of patients with fatigue were chosen. Articles based on studies at referral and specialty centres were given less weight than those based on studies in family physicians' offices. MAIN MESSAGE: Adherence to these guidelines will decrease the cost of investigating the symptom of fatigue and optimize diagnosis and management. This needs to be proved in practice, however, and with research that produces level 1 and 2 evidence. CONCLUSIONS: Adults presenting with fatigue of less than 6 months' duration should be assessed for psychosocial causes and should have a focused history and physical examination to determine whether further investigations should be done. The guidelines outline investigations to be considered. The elderly require special consideration. These guidelines have group validation, but they need to be tested by more physicians in various locations and types of practices.  (+info)

Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer. (6/2703)

PURPOSE: To evaluate the feasibility of administering topotecan in combination with paclitaxel and cisplatin without and with granulocyte colony-stimulating factor (G-CSF) support as first-line chemotherapy in women with incompletely resected stage III and stage IV ovarian carcinoma. PATIENTS AND METHODS: Starting doses were paclitaxel 110 mg/m2 administered over 24 hours (day 1), followed by cisplatin 50 mg/m2 over 3 hours (day 2) and topotecan 0.3 mg/m2/d over 30 minutes for 5 consecutive days (days 2 to 6). Treatment was repeated every 3 weeks. After encountering dose-limiting toxicities (DLTs) without G-CSF support, the maximum-tolerated dose was defined as 5 microg/kg of G-CSF subcutaneously starting on day 6. RESULTS: Twenty-one patients received a total of 116 courses at four different dose levels. The DLT was neutropenia. At the first dose level, all six patients experienced grade 4 myelosuppression. G-CSF support permitted further dose escalation of cisplatin and topotecan. Nonhematologic toxicities, primarily fatigue, nausea/vomiting, and neurosensory neuropathy, were observed but were generally mild. Of 15 patients assessable for response, nine had a complete response, four achieved a partial response, and two had stable disease. CONCLUSION: Neutropenia was the DLT of this combination of paclitaxel, cisplatin, and topotecan. The recommended phase II dose is paclitaxel 110 mg/m2 (day 1), followed by cisplatin 75 mg/m2 (day 2) and topotecan 0.3 mg/m2/d (days 2 to 6) with G-CSF support repeated every 3 weeks.  (+info)

Manganese sulfate-dependent glycosylation of endogenous glycoproteins in human skeletal muscle is catalyzed by a nonglucose 6-P-dependent glycogen synthase and not glycogenin. (7/2703)

Glycogenin, a Mn2+-dependent, self-glucosylating protein, is considered to catalyze the initial glucosyl transfer steps in glycogen biogenesis. To study the physiologic significance of this enzyme, measurements of glycogenin mediated glucose transfer to endogenous trichloroacetic acid precipitable material (protein-bound glycogen, i.e., glycoproteins) in human skeletal muscle were attempted. Although glycogenin protein was detected in muscle extracts, activity was not, even after exercise that resulted in marked glycogen depletion. Instead, a MnSO4-dependent glucose transfer to glycoproteins, inhibited by glycogen and UDP-pyridoxal (which do not affect glycogenin), and unaffected by CDP (a potent inhibitor of glycogenin), was consistently detected. MnSO4-dependent activity increased in concert with glycogen synthase fractional activity after prolonged exercise, and the MnSO4-dependent enzyme stimulated glucosylation of glycoproteins with molecular masses lower than those glucosylated by glucose 6-P-dependent glycogen synthase. Addition of purified glucose 6-P-dependent glycogen synthase to the muscle extract did not affect MnSO4-dependent glucose transfer, whereas glycogen synthase antibody completely abolished MnSO4-dependent activity. It is concluded that: (1) MnSO4-dependent glucose transfer to glycoproteins is catalyzed by a nonglucose 6-P-dependent form of glycogen synthase; (2) MnSO4-dependent glycogen synthase has a greater affinity for low molecular mass glycoproteins and may thus play a more important role than glucose 6-P-dependent glycogen synthase in the initial stages of glycogen biogenesis; and (3) glycogenin is generally inactive in human muscle in vivo.  (+info)

Fatigue in advanced cancer: a prospective controlled cross-sectional study. (8/2703)

Uncontrolled studies have reported that fatigue is a common symptom among patients with advanced cancer. It is also a frequent complaint among the general population. Simply asking cancer patients whether or not they feel fatigued does not distinguish between the 'background' level of this symptom in the community and any 'excess' arising as a result of illness. The aim of this study was to determine the prevalence of fatigue among palliative care inpatients in comparison with a control group of age and sex-matched volunteers without cancer. In addition, the correlates of fatigue were investigated. The prevalence of 'severe subjective fatigue' (defined as fatigue greater than that experienced by 95% of the control group) was found to be 75%. Patients were malnourished, had diminished muscle function and were suffering from a number of physical and mental symptoms. The severity of fatigue was unrelated to age, sex, diagnosis, presence or site of metastases, anaemia, dose of opioid or steroid, any of the haematological or biochemical indices (except urea), nutritional status, voluntary muscle function, or mood. A multivariate analysis found that fatigue severity was significantly associated with pain and dypnoea scores in the patients, and with the symptoms of anxiety and depression in the controls. The authors conclude that subjective fatigue is both prevalent and severe among patients with advanced cancer. The causes of this symptom remain obscure. Further work is required in order to determine if the associations reported between fatigue and pain and between fatigue and dyspnoea are causal or coincidental.  (+info)

Cancer-related fatigue (CRF) is one of the most common symptoms experienced by cancer patients (CPs). The Brief Fatigue Inventory (BFI) is a reliable instrument to assess CRF in CPs. The aim of this s
Protracted treatment on intensive care unit (ICU) sets the patients at increased risk for the development of chronic critical illness (CCI). Muscular and cardio-respiratory deconditioning are common long-term sequelae, going along with a state of chronic fatigue. At present, findings regarding the frequency, long-term course, and associated factors of self-reported fatigue following ICU treatment of CCI patients are lacking. CCI patients with the diagnosis of critical illness polyneuropathy/myopathy (CIP/CIM) were assessed at three time points. Four weeks following the discharge from ICU at acute care hospital (t1), eligibility for study participation was asserted. Self-reported fatigue was measured using the Multidimensional Fatigue Inventory (MFI-20) via telephone contact at 3 (t2, n = 113) and 6 months (t3, n = 91) following discharge from ICU at acute care hospital. At both 3 and 6 months, nearly every second CCI patient showed clinically relevant fatigue symptoms (t2/t3: n = 53/n = 51, point
Cancer-related fatigue is a subjective symptom of fatigue that is experienced by nearly all cancer patients. Among patients receiving cancer treatment other than surgery, it is essentially universal. Fatigue is a normal and expected side effect of most forms of chemotherapy, radiation therapy, and biotherapy. On average, cancer-related fatigue is "more severe, more distressing, and less likely to be relieved by rest" than fatigue experienced by healthy people. It can range from mild to severe, and may be either temporary or a long-term effect. Fatigue may be a symptom of the cancer, or it may be the result of treatments for the cancer. The National Comprehensive Cancer Network defines cancer-related fatigue as "a distressing persistent, subjective sense of physical, emotional and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning". Cancer-related fatigue is a chronic fatigue (persistent ...
Background and objectives: To explore if intravenous iron isomaltoside (Monofer ®) leads to a better relief of fatigue than current treatment practice with oral iron in women suffering from severe fatigue after postpartum hemorrhage. Materials and methods: This is a subanalysis of a single-center, open-label, randomized controlled trial conducted in women suffering from postpartum hemorrhage. Participants were randomized 1:1 to 1200 mg iron isomaltoside or current treatment practice with oral iron. We measured fatigue by the Multidimensional Fatigue Inventory (MFI) and Edinburgh Postnatal Depression Scale, and determined hematological parameters. The subanalysis includes all participants with a high fatigue score (MFI physical fatigue score ,15) at inclusion. The primary endpoint was aggregated change in physical fatigue score from inclusion to 12 weeks postpartum with a predefined minimum clinically relevant difference of 1.8. The trial is registered at ClinicalTrials.gov (identifier: ...
Fatigue is a common problem among individuals with Parkinsons disease (PD). It may occur before the overt symptoms of bradykinesia, rigidity and tremor. Little is understood about how to measure fatigue in PD. Here we determined the dimensionality of the constructs of fatigue. Four recommended scales, the Fatigue Severity Scale, Functional Assessment of Chronic Illness Therapy-Fatigue, Parkinson Fatigue Scale and Visual Analog Fatigue Scale (VAFS) were tested against quality of life measures including cognition, depression, sleep, life orientation, physical activity and PD symptoms in 22 PD subjects and 15 caregivers. Fatigue was associated with many quality of life variables, with the PDQ-39 summary index showing the strongest association. PD subjects agreed more strongly than caregivers that they experienced higher levels of fatigue. 27% of PD subjects rated fatigue as one of their top three most bothersome symptoms. The constructs of fatigue was captured within one dimension which explained 67% of
ASCO Abstract Number: 9004. CHICAGO - Cancer-related fatigue is often a major problem for cancer patients, beginning at diagnosis, during treatment and after completing therapy. Researchers at Mayo Clinic and the North Central Cancer Treatment Group (NCCTG) recently completed a study testing methylphenidate in the treatment of cancer-related fatigue and found that, while it did not improve fatigue for a broad group of patients, the data did not rule out a benefit for those with stage III/IV cancer. Results of this NCCTG study, N05C7, will be presented on Sunday, June 6, 2010, at the American Society of Clinical Oncology annual meeting in Chicago.. VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Dr. Deb Barton is available on the Mayo Clinic News Blog.. "Cancer-related fatigue can impact a patients ability to tolerate therapy and their overall quality of life," says Debra Barton, R.N., Ph.D., associate professor of oncology at Mayo Clinic in ...
SIG members first examined the subjective fatigue experience dimension of the Checklist Individual Strength (CIS20-R) [20], a well validated and widely used multidimensional self-report measure that aims to assess subjective experience of fatigue, concentration, motivation, and physical activity. Some SIG members expressed the view that the 8 items of the fatigue subscale seemed to evaluate peripheral or muscle fatigue consecutive to physical activity rather than central fatigue per se. Others were of the opinion that the subjective fatigue items appeared to have been devised for healthy people rather than for individuals with chronic neuromuscular conditions. In addition, SIG members expressed some concerns regarding the content validity of the fatigue subscale, most items seemingly focusing on physical fatigue and not sufficiently documenting aspects of mental fatigue or weariness that many patients typically feel upon morning awakening. Moreover, many items are not plausible for DM1. For ...
When sarcoidosis is in clinical remission, complaints of chronic fatigue often persist. The exact features of this post-inflammatory fatigue are unknown. This study assesses the severity of fatigue and the presence of fatigue-related symptoms in sarcoidosis-in-clinical-remission. Furthermore, we evaluate psychological distress, pain and patient-reported sleep quality, and record physical activity levels and muscle strength as objective assessments of fatigue. Lastly, we assess the severity of fatigue at a follow-up.. Methods: Seventy-five patients with sarcoidosis-in-clinical-remission were evaluated with the Checklist Individual Strength (fatigue), the SymptomChecklist-90 (psychological distress), the McGill Pain Questionnaire (pain), standardized interview (fatigue-related symptoms), sleep diary, accelerometer and muscle strength tests.. Results: Fatigue severity mean score in sarcoidosis patients in-clinical-remission was high (fatigue-severity score: 30.5±15.5), and fatigue-related symptoms ...
Cancer-related fatigue is a symptom with great implications for the quality of life of those that experience it. It is regarded as one of the most distressing symptoms that people with cancer develop. Its aetiology is complex, and although the mechanisms underlying fatigue have not been fully clarified it is evident that it is exacerbated by treatments intended to cure or palliate the disease. Patients at risk of cancer-related fatigue need access to information that will enable them to manage it effectively. There are a growing number of materials available to patients in different European countries on this topic, but it is unclear how useful patients find these. This study was undertaken to explore this through conducting focus groups with patients in the United Kingdom and Switzerland. One focus group was conducted in each country. Findings from these determined that individuals voiced common concerns: fatigue had not been addressed in the clinical setting - individuals surmised why this ...
Brief Fatigue Inventory (BFI) consist of 3 items that assess the severity of fatigue and 6 items that assess the impact of fatigue on daily functioning in a 10-points scale with 0 as no fatigue or does not interfere with daily functioning and 10 as bad fatigue or completely interferes. The scores for the six items were summed up to form a total interference score. The linear analogue scale of fatigue was a 10-points scale with 0 as no fatigue and 10 as bad fatigue. All scores were then transformed into 0 to 100 scale, with 100 as less fatigue/less interference. Change from baseline to week 4 was calculated by subtracting the baseline scores from the scores at week 4 ...
Change between Day 7 to Baseline in FACIT-F (Functional Assessment of Chronic illness Therapy-Fatigue) & FACT-G (Functional Assessment of Cancer Therapy-General) scores. Participants rate quality of life using FACT-G consisting of 33 questions with 5 domains assessing physical and social, emotional & functional well being & relationship with physician, remaining 5 assess extent to which each domain affects overall quality of life on 5-point scale from 0 (not at all) to 4 (very much); total score obtained by summing individual subscale scores (0-132). FACIT-F consists of 13 items where participants rate intensity of fatigue & its related symptoms on a scale of 0-4 from 0 not at all to 4 very much. The responses to FACIT fatigue questionnaire are each measured on 4‐point Likert scale with total score ranges from 0 to 52. High scores represent less fatigue. Reported is the mean change of the summed value of all reported scores for the FACT-G or the FACIT-F from baseline to Day 7 ...
Chronic fatigue related to cancer is a common syndrome during and following cancer treatment that manifests as a constant lack of energy that is not brought on by exertion, nor relieved by sleep. While cancer-related fatigue is not a well understood problem that can be associated with any single cause, consensus by health authorities is that it is a multifactorial problem involving the bodys reaction to both chemotherapy and radiation therapy; anemia resulting from decreased red blood cells that leaves tissues oxygen starved; and/or a decrease of vital nutrients.. One proposed source of a centuries-old treatment for people suffering from fatigue similar to that experienced by cancer patients is the use of adaptogens. Adaptogens are a class of herbal remedies noted for their potency as stress fighters capable of either bringing an overly stressed body back to its normal healthy state or in coping with stressors such as physical exertion, toxins, lack of sleep and psychological distress.. One of ...
The overall purpose was to explore the experience of living with chronic heart failure among patients in primary healthcare. Comparisons were made between patients with confirmed heart failure (HF, n=49), patients with symptoms indicating HF but with no HF (NHF, n=59), and a reference group (n=40). The mean age was 77 years. Patients in the HF and NHF groups had more general and physical fatigue, more reduced activity, worse physical quality of life and higher degree of depression compared with the reference group. The HF group had also higher degree of physical fatigue and worse physical quality of life than the NHF group. When comparing degrees of depression between the three groups and adjusting for fatigue, the physical dimension of fatigue was of greater importance in explaining group differences. In the HF group general fatigue was more closely related to limitations in role functioning for physical reasons than to reduced physical function per se. Women experienced more fatigue than men. ...
There is no way to know whether you will have fatigue or how bad it will be. But there are things you can do to help fight fatigue. Here are 7 tips to help manage cancer-related fatigue.
The etiology of severe fatigue in T1DM is not well understood. It seems obvious that physiological diabetes-related factors such as haemoglobin A1c (HbA1c) levels or variations in blood glucose levels are associated with fatigue. While fatigue is a classical presenting symptom of hyperglycaemia, in our cross-sectional study no relationship between glucose control (HbA1c levels) and fatigue severity was found [3]. Also, parameters gathered during continuous glucose monitoring such as the blood glucose variability were unrelated to persistent fatigue. Other diabetes-related factors were correlated to fatigue: the number of complications due to diabetes, diabetes-related distress and diabetes specific self-efficacy. Also, there was a univariate relationship between fatigue and somatic comorbidity. In a multiple regression, several cognitive behavioural factors were found to be potential determinants of fatigue: disrupted sleep-wake patterns, low physical activity, catastrophising thoughts about ...
OBJECTIVE: Cancer-related fatigue (CRF) is one of the most common unrelieved symptoms experienced by patients. CRF is underrecognized and undertreated due to a lack of clinically sensitive instruments that integrate easily into clinics. Modern computerized adaptive testing (CAT) can overcome these obstacles by enabling precise assessment of fatigue without requiring the administration of a large number of questions. A working item bank is essential for development of a CAT platform. The present report describes the building of an operational item bank for use in clinical settings with the ultimate goal of improving CRF identification and treatment. STUDY DESIGN AND SETTING: The sample included 301 cancer patients. Psychometric properties of items were examined by using Rasch analysis, an Item Response Theory (IRT) model. RESULTS AND CONCLUSION: The final bank includes 72 items. These 72 unidimensional items explained 57.5% of the variance, based on factor analysis results. Excellent internal ...
Results Sjögrens patients had higher scores on all five fatigue dimensions (p,0.001) and lower scores on moderate and vigorous intensity activity (p≤0.001) compared with control participants. In the Sjögrens group, lower physical activity and higher activity avoidance and somatic focus were associated with more severe fatigue on most fatigue dimensions. For general fatigue and physical fatigue, especially the combination of low physical activity and high activity avoidance was associated with more severe fatigue (p,0.05).. ...
Fatigue in patients with cancers of the breast or prostate undergoing radical radiotherapy. To determine the prevalence, severity, and correlates of fatigue among patients with cancers of the Prostate or breast receiving high dose radiotherapy with curative intent, a prospective, questionnaire based study, evaluated a convenience sample of 62 patients who were about to start a course of radiotherapy. Patients were assessed immediately prior to treatment, and again within a week of finishing. Fatigue was assessed using the Fatigue Severity Scale (FSS) and the Bidimensional Fatigue Scale (BFS). Quality of life was assessed using the European Organisation for Research and Treatment of Cancer 30-item Quality of Life Questionnaire (EORTC QLQc30). Psychological distress was assessed using the Hospital Anxiety and Depression Scale (HADS). Personality Traits were assessed using the Eysenck Personality Inventory (EPI). Fatigue severity increased significantly on 3 out of the 5 assessment instruments ...
The objective of this study was to examine whether multiple sclerosis (MS)-related fatigue affects patients cognitive performance. Thirty patients who had substantial fatigue in conjunction with MS and who reported marked diurnal variability in the severity of their fatigue were tested on two occasions: during a period of high fatigue and during a period of relatively low fatigue. The order of these sessions was counterbalanced across patients. During both sessions, patients completed a questionnaire concerning their present state of fatigue and a battery of neuropsychological tests of planning, selective attention, and paired associate learning. Although patients confirmed greater fatigue during the period of high fatigue and felt they had performed more poorly during this period, there were no differences in cognitive performance that could be attributed to fatigue. Instead, all subjects showed improvement from the first to the second session regardless of whether the latter entailed a period ...
Fatigue occurs frequently in patients with cancer, neurological diseases and chronic inflammatory diseases, but the biological mechanisms that lead to and regulate fatigue are largely unknown. When the innate immune system is activated, heat shock proteins (HSPs) are produced to protect cells. Some extracellular HSPs appear to recognize cellular targets in the brain, and we hypothesize that fatigue may be generated by specific HSPs signalling through neuronal or glial cells in the central nervous system. From a cohort of patients with primary Sjögrens syndrome, 20 patients with high and 20 patients with low fatigue were selected. Fatigue was evaluated with a fatigue visual analogue scale. Plasma concentrations of HSP32, HSP60, HSP72 and HSP90α were measured and analysed to determine if there were associations with the level of fatigue. Plasma concentrations of HSP90α were significantly higher in patients with high fatigue compared with those with low fatigue, and there was a tendency to ...
Exercise and/or psychological interventions are more effective strategies than pharmaceutical interventions to reduce cancer-related fatigue.
Stone, P, Ream, E, Richardson, A, Thomas, H, Andrews, P, Campbell, P, Dawson, T, Edwards, J, Goldie, T, Hammick, M et al, Kearney, N, Lean, M, Rapley, D, Smith, AG, Teague, C and Young, A. (2003) Cancer-related fatigue - a difference of opinion? Results of a multicentre survey of healthcare professionals, patients and caregivers ...
The objective of this study is to develop a structured and evidence-based self-management program to cope with cancer-related fatigue and to assess the
Horneber, M; Fischer, I; Dimeo, F; Rüffer, J U; Weis, J Cancer-Related Fatigue: Epidemiology, Pathogenesis, Diagnosis, and Treatment Dtsch Arztebl Int 2012; 109(9): ; DOI: /arztebl
OBJECTIVE: To examine patient-reported outcomes (PROs) in patients with different rheumatoid arthritis (RA) disease activity levels and identify residual symptoms. METHODS: Post hoc analyses of overall and Japanese data from two randomized controlled trials including RA patients with previous inadequate responses to methotrexate (NCT01710358) or no/minimal previous disease-modifying antirheumatic drug treatment (NCT01711359) (sponsor: Eli Lilly and Company). Week 24 assessments were disease activity (Simplified Disease Activity Index, Disease Activity Score/Disease Activity Score 28 joints-erythrocyte sedimentation rate) and PROs (pain visual analog scale [VAS], morning joint stiffness [MJS], Health Assessment Questionnaire-Disability Index, Functional Assessment of Chronic Illness Therapy-Fatigue, and Medical Outcomes Study Short Form 36 Health Survey Physical and Mental Component Scores ...
Objective. Sleep disturbance and chronic fatigue are common in rheumatoid arthritis (RA) and contribute to disability, symptomatology, and healthcare use. It has long been recognized in other populations that exercise can improve sleep and diminish fatigue. The effect of exercise on sleep quality and fatigue in RA has not been evaluated. Methods. Ours is a randomized controlled study in RA to determine the effect of an exercise program on sleep quality and fatigue. These were measured using the Pittsburgh Sleep Quality Index and the Fatigue Severity Scale. Patients were randomized to either a 12-week, home-based exercise intervention or usual care. The exercise program consisted of specific exercises to target individual deficiencies identified using the Health Assessment Questionnaire (HAQ) with cardiovascular work as per the guidelines. The intervention group was evaluated on a 3-week basis. Full evaluation was carried out at baseline and at 12 weeks. Results. Forty patients were randomized to ...
Context: High quality fatigue rating scales are needed to advance understanding of fatigue nd determine the efficacy of interventions. Several fatigue scales are used in Parkinsons isease, but few have been tested using modern psychometric methodology (Rasch analysis).. Objectives: To examine the measuring properties of the generic Functional Assessment of hronic Illness Therapy - Fatigue (FACIT-F) scale and the condition-specific 16-item arkinson Fatigue Scale (PFS-16) using Rasch analysis.. Methods: Postal survey data (n=150; 47% women; mean age, 70) were Rasch analyzed. FS-16 scores were tested according both to the original polytomous and the suggested lternative dichotomized scoring methods.. Results: The PFS-16 showed overall Rasch model fit whereas the FACIT-F showed signs of isfit, which probably was due to a sleepiness-related item and mixing of ositively/negatively worded items. There was no differential tem functioning by disease uration but by fatigue status (greater likelihood of ...
Fatigue detection software is intended to reduce fatigue related fatalities and incidents. Several companies are working on a technology for use in industries such as mining, road- and rail haulage and aviation. The technology may soon find wider applications in industries such as health care and education. In an operational environment scenario where operating systems are dependent on human performance, fatigue can be defined as an inclination to degrade performance. Thus, fatigue is an indicator of baseline risk for the occurrence of errors and accidents. Globally mining operations are at risk of fatigued workers. Sleepiness and fatigue increase human error and contribute to accidents which can be fatal. Factors compounding fatigue levels in mine workers include; disruptions in circadian rhythms due to shift work, exposure to noise, vibration and chemicals, monotonous and repetitive nature of tasks and night shift driving. Studies recognise a connotation between lifestyle and fatigue. Mine ...
Background. Fatigue is a frequently reported symptom in women following early breast cancer treatment and may be increased with adjuvant breast radiotherapy (RT). Within the START Quality of Life (QoL) sub study the effect of a range of clinical and psychological factors and symptoms on fatigue is investigated in women following RT for early stage breast cancer.. Method. A subgroup of women were recruited to the QoL study and completed the EORTC QLQ C-30, BR23 and HADS at baseline (after surgery +/- chemotherapy (CT) but before RT) and at 6, 12, 24 and 60 months. Fatigue was measured as a symptom subscale comprised of 3 individual items. The effect of age, time from surgery, type of surgery, CT, endocrine therapy, RT schedule and change over time were tested using a GEE model. Correlations between fatigue and anxiety, depression, insomnia and physical functioning were examined.. Results. 2180 (99%) women completed baseline QoL. Fatigue levels were highest pre RT (median 33.33) and decreased ...
PURPOSE: Fatigue is a symptom in patients with chronic gastrointestinal (GI) and liver diseases. Different instruments have been developed to assess the severity of fatigue and the 40-item Fatigue Impact Scale (FIS) is among the most widely used. Shorter versions of FIS include the 21-item Modified Fatigue Impact Scale (MFIS), and an eight-item version for everyday use. The study aimed to assess construct validity, reliability, and sufficiency of the raw score of the original FIS with 40 items, and examine the sufficiency of the 21 items from the Modified scale and the eight items of the Daily Fatigue Impact Scale (D-FIS), all of which are embedded in the 40-item scale ...
Introduction: Fatigue is the most troublesome untreated symptom during radical breast radiotherapy. This situation persists due to an uncertain aetiology and an inability to identify patients at high risk of experiencing significant fatigue during subsequent radiotherapy. Aetiological investigations of the current study concentrated on discriminating the radiotherapy-specific effects on fatigue, in a context encompassing multiple psychological and physiological covariates. Prognostic aspects sought to characterise a high-risk patient. Methods: The study cohort comprised 100 women, diagnosed with Stage 0 to IIA breast cancer, and prescribed standard whole breast irradiation to 40Gy in 15 fractions over three weeks. The use of systemic therapies was an exclusion criterion. A cytokine-induced sickness behaviour model framed the study investigations, and provided a theoretical link between localised radiotherapy and systemic fatigue. The outcome fatigue was assessed before, during and four weeks ...
The Fatigue Severity Score (FSS), the Fatigue Impact Scale (FIS), and the ModifiedFatigue Impact Scale (MFIS) are the most commonly used scales for fatigue assess-ment in MS patients.The FSS is composed of 9 items that assess perceivedSubjects are asked to assign a number from 1 (strongly disagree) to 7(strongly agree) stating their agreement with each statement.Responses aresummed and averaged, with a score of 4 or more indicating significant The FIS has been identified by the Multiple Sclerosis Council for Clinical Practice Guidelines as the most appropriate for assessing the impact of MS-related fatigueon quality of life.The FIS is a retrospective tool designed to evaluate fatigue duringthe past month. The FIS has separate subscales for physical, psychosocial, andcognitive functions, which span more than 40 statements.Subjects are asked toscore the effect of fatigue on those 4 dimensions using a 5-point scale from 0 (noproblem) to 4 (extreme problem). Since the FIS takes approximately 10 to ...
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Overcoming Barriers. Fatigue. Fatigue is common in MS, exercise and fatigue management education strategies will actually help your fatigue level in the long term(8).. Heat Sensitivity and MS. Physical and sensory symptoms may temporarily increase with small increases in environmental or body temperature. People with MS should be encouraged to keep cool and well hydrated during exercise sessions, for example using cool clothing and try to exercise inside or in the shade.. Research is continuing to address what exercise and strategies are best for fatigue and heat sensitivity; for now it is recommended to follow the Physical activity guidelines, remember to build up to these guidelines slowly. Stretching exercises are important too, and continuing these when fatigue levels, or temperatures, are high is still important.. Finding support. Support to help you exercise is not to be underestimated. Research indicates that learning about exercise, working with other to overcome your barriers and ...
METHODS: This randomized controlled clinical trial was carried out in a multiple sclerosis clinic in Iran, where 37 outpatient women with MS were randomized into an exercise group (N.=18) and a control group (N.=19). In the exercise group, aquatic exercise was performed for 45 minutes, 3 times per week for 8 weeks. The control group did not receive any interventions (aquatic exercise) and were asked to maintain their normal treatments. The severity and perception of fatigue and quality of life (QoL) were measured using the Fatigue Severity Scale (FSS), Modified Fatigue Impact Scale (MFIS), and Multicultural Quality of Life Index (MQLIM) questionnaires ...
TY - JOUR. T1 - Is fatigue a disease-specific or generic symptom in chronic medical conditions?. AU - Menting, Juliane. AU - Tack, Cees J. AU - Bleijenberg, Gijs. AU - Donders, Rogier. AU - Droogleever Fortuyn, Hal A. AU - Fransen, Jaap. AU - Goedendorp, Martine M. AU - Kalkman, Joke S. AU - Strik-Albers, Riet. AU - van Alfen, Nens. AU - van der Werf, Sieberen P. AU - Voermans, Nicol C. AU - van Engelen, Baziel G. AU - Knoop, Hans. N1 - (c) 2018 APA, all rights reserved).. PY - 2018/6. Y1 - 2018/6. N2 - OBJECTIVE: Severe fatigue is highly prevalent in various chronic diseases. Disease-specific fatigue models have been developed, but it is possible that fatigue-related factors in these models are similar across diseases. The purpose of the current study was to determine the amount of variance in fatigue severity explained by: (a) the specific disease, (b) factors associated with fatigue across different chronic diseases (transdiagnostic factors), and (c) the interactions between these factors and ...
BSAP: Bone-Specific Alkaline Phosphatase; FACIT-Fatigue: Functional Assessment of Chronic Illness Therapy-Fatigue; HRQOL: health-Related Quality of Life; IGFBP: Insulin-like Growth Factor Binding Protein; IL: Interleukin; IGF: Insulin-like Growth Factor; MASQ: Multiple Abilities Self-Report Questionnaire; NTx: N-Telopeptides of Type I Collagen; IES-R: Impact of Event Scale-Revised; POMS-SF: Profile of Mood States-Short Form; RSE: Rosenberg Self-Esteem Scale; bold text with*: statistically significant ...
The cyclic material behavior is investigated, by strain-controlled testing, of 8 mm thick sheet metal specimens and butt joints, manufactured by manual gas metal arc welding (GMAW). The materials used in this investigation are the high-strength structural steels S960QL, S960M and S1100QL. Trilinear strain-life curves and cyclic stress-strain curves have been derived for the base material and the as-welded state of each steel grade. Due to the cyclic softening in combination with a high load level at the initial load cycle, the cyclic stress-strain curve cannot be applied directly for a fatigue assessment of welded structures. Therefore, the transient effects have been analyzed in order to describe the time-variant material behavior in a more detailed manner. This should be the basis for the enhancement of the fatigue life estimation ...
Methods In a two center subgroup analysis from the ADAPTHERA cohort, we studied quality of life indexes such as Hannover Functional Ability Questionnaire (HFAQ), Health Assessment Questionnaire (HAQ), EuroQol-5D-3L (EQ-5D-3L), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) and World Health Organisation-5 Well Being Index (WHO-5) in patients with VERA. Moreover, we examined the statistical relationship of these indexes with various clinical and laboratory RA associated parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF)-/ cyclic citrullinated peptide antibodies (anti-CCP)-status and Disease Activity Score 28 (DAS28) as well as its components [counts of tender and swollen joints, Visual Analogue Scale (VAS)]. ...
This study, the first of its kind in chronic stroke, has demonstrated that self-reported post-stroke fatigue is significantly reduced after 6 weeks of modafinil therapy compared with placebo. In addition to the reduction in fatigue, it was observed that there was a significant improvement in participants quality of life. The secondary fatigue measure, the FSS, also showed a significant reduction in participants self-reported fatigue, confirming the primary end point. However, no significant change was reported for mood or cognition with modafinil therapy. These positive findings are encouraging, but preliminary, owing to the small size of the study.. The reported significant improvement in patient quality of life was due mainly to improvement in the subdomains of energy, mobility, social roles, vision, and thinking, which are critically important aspects of post-stroke life. Although there was no statistically significant improvement in the subdomains of family, language, mood, personality, ...
Abstract: Purpose/Objectives: To test whether sleep disturbance mediates the effect of pain on fatigue. Design: Cross-sectional Setting: Radiation therapy clinic, oncology ambulatory clinic, and inpatient oncology unit in an urban teaching hospital. Sample: 84 patients with cancer with multiple primary diagnoses who were experiencing pain. Fifty-three percent were female and 92% were Caucasian, with a mean age of 54 years. Methods: All participants completed a symptom questionnaire that included the brief pain inventory - short form, the Pittsburgh Sleep Quality Index, and the fatigue subscale of the Profile of Mood States questionnaire. Multistage linear regression was used to test a mediation model. Main Research Variables: Fatigue, pain, and sleep disturbance. Findings: Mediation analyses indicate that pain influences fatigue directly as well as indirectly by its effect on sleep. About 20% (adjusted R2 = 0.20) of the variation in fatigue is explained by pain. Thirty-five percent of the ...
Aim: The aim of this study was to investigate balance problems and affecting factors in stable chronic obstructive pulmonary disease (COPD) patients.. Methods: Patients who were hospitalized in the department of chest disease with a diagnosis of COPD with stable clinical condition participated in this study. Functional balance of patients was assessed by Berg Balance Scale (BBS). Tampa Scale for Kinesiophobia (TSK) was used to inquire fear of effort adapted symptom of dyspnea. Fatique was examined by Checklist Individual Strength (CIS) Scale. Severity of dyspnea was evaluated using Medical Research Council Scale (MRCS).. Results: A total of 30 patients, 4 women and 26 men were enrolled (mean age= 62.0 ± 10.4 years, mean body mass index= 24.09 ± 4.2 kg/m2). Mean FEV1% predicted was 29.46 ± 14.75. Cases was found with a moderate risk of falling (mean BBS score= 34.16 ± 15:58). The fear of effort due to dyspnea was found to be high (mean TSK score= 42.0 ± 14.6). There was no relationship ...
TY - JOUR. T1 - Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. AU - Schwartz, A. L.. AU - Mori, M.. AU - Gao, R.. AU - Nail, L. M.. AU - King, M. E.. PY - 2001. Y1 - 2001. N2 - SCHWARTZ, A. L., M. MORI, R. GAO, L. M. NAIL, and M. E. KING. Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med. Sci. Sports Exerc., Vol. 33, No. 5, 2001, pp. 000-000. Purpose: Cancer treatment-related fatigue is the most prevalent and distressing symptom of cancer therapy. Interventions to minimize fatigue are needed. The purpose of this study was to examine the relationship between exercise and fatigue over the first three cycles of chemotherapy in women receiving either cyclophosphamide, methotrexate, and fluorouracil (CMF) or doxorubicin and cyclophosphamide (AC) for breast cancer. Methods: Seventy-two newly diagnosed women with breast cancer were instructed in a home-based moderate-intensity exercise intervention. Measures of functional ability, ...
This study demonstrated that fatigue levels are high in patients with SSc compared with the general population, which is consistent with the results of a recent systematic review that found that fatigue related to SSc was significantly higher than in general population samples and similar to patients with other rheumatic diseases or patients with cancer in active treatment (10). In multivariate analysis, statistically significant correlates of fatigue included number of medical comorbidities, patient-reported breathing problems, patient-reported number of GI symptoms, and smoking. Tender joint count also approached statistical significance. Physician-rated global disease severity was a robust predictor of fatigue on a bivariate basis and after controlling for sociodemographic factors, but was no longer statistically significant when medical comorbidities and specific disease factors were included in the model. Depressive symptoms and pain were robust predictors of fatigue, but sociodemographic ...
In this study, re-activation of salivary HHV-6 was observed in 9 of 17 subjects before the supplement intake, and the salivary HHV-6 was decreased to less than the detection limit after intake of the oyster meat extract powder other than 1 subject. The results and discussion described above indicate that the intake of oyster meat extract powder probably reduced the objective fatigue levels and subjective fatigue feeling in the healthy adults who accumulate usual fatigue through the inhibition of re-activation of viruses by controlling the generation of cytokines. Chronic fatigue syndrome (CFS) is a disease by which strong fatigue is felt for a half year or longer without any obvious reasons, and the cause of CFS has been unknown even now. The decrease of the homeostasis of immune system induced by various kinds of environmental factors (physical and psychological stress) and genetic factors is proposed for the mechanism of onset of CFS as a hypothesis [22]. Chalders fatigue scale and the ...
BACKGROUND: Fatigue is associated with cancer and its treatment but we know little about how many and which patients suffer fatigue of clinical severity. We aimed to determine the prevalence of clinically relevant fatigue (CRF) and its associations in outpatients with various cancer diagnoses. PATIENTS AND METHODS: A survey of outpatients with colorectal, breast, gynaecological, genitourinary, sarcoma, melanoma and miscellaneous tumours at a regional cancer centre. Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) fatigue subscale and the Hospital Anxiety and Depression Scale (HADS). These self-report data were linked to demographic and clinical variables. Data were available on 2867 outpatients. RESULTS: The prevalence of CRF (EORTC fatigue subscale | or =40) was 32% (95% confidence interval 31-34%). The variables independently associated with CRF were primary cancer site, having disease present, type of cancer treatment and emotional distress (total HADS score |
Lowry Drug Anti Fatigue Caps 90 Capsules [H160252] - Reduce ammonia & reduce fatigue Scavenge excess ammonia to reduce fatigue. Prolong endurance, even in ultra workouts or races. Increase glycogen availability for energy production. Help prevent cramps. Gluten-Free and Vegan Friendly. Extra Benefits:Although Anti-Fatigue Caps is designed primarily for ammonia reduction in long distance events, the nutrients in the formula are excellent for helping counteract everyday fatigue, even chronic fatigue symptoms. Thoroughly tested over several years in the most extreme athletic endurance events, Anti-Fatigue Caps helps remove fatigue-causing, performance-robbing ammonia. During extended endurance exercise the body accumulates excess ammonia from protein metabolism, which interferes with glycogen production, disrupting energy output. Anti-Fatigue Caps is a one-of-a-kind supplement combining two well-known ammonia-scavenging nutrients. Clean up the waste products of combustion, or youll pay the price. To stay
The effects of surface active additives on rolling-element fatigue life were investigated with the five-ball fatigue tester at conditions where classical subsurface initiated rolling-element fatigue is the sole mode of failure. Test balls of AISI 52100, AISI M-50, and AISI 1018 were run with an acid-treated white oil containing either 2.5 percent sulfurized terpene, 1 percent didodecyl phosphite, or 5 percent chlorinated wax. In general, it was found that the influence of surface active additives was detrimental to rolling-element fatigue life. The chlorinated-wax additive significantly reduced fatigue life by a factor of 7. The base oil with the 2.5 percent sulfurized-terpene additive can reduce fatigue life by as much as 50 percent. No statistical change in fatigue life occurred with the base oil having the 1 percent didodecyl-phosphite additive. The additives used with the base oil did not change the ranking of the bearing steels where rolling-element fatigue life was of subsurface origin.
Staying active is beneficial on many levels including maintaining physical fitness, reaching weight loss goals, reducing fatigue and optimizing cardiovascular health but participating in physical activities should be preceded by practicing senior balance exercises. Please see more information at http://www.exerciseforbalance.com/buy-now Facing fatigue is a common problem among many older individuals. Fatigue can be a result of difficulties with sleeping through the night. Fatigue can be a secondary result of an increased sedentary lifestyle, adopted by many senior citizens. Additionally, fatigue can be caused by cancer and cancer treatments. Whether from the disease itself or the treatment, cancer can be exhausting, but a new review says there are ways to beat back cancer-related fatigue. Recently, Karen Mustian published a study that revealed that exercise can help reduce the fatigue that accompanies cancer and cancer treatments. "Exercise and psychological treatment, and the combination of ...
parallel group phase III trial with an adaptive sample size re-estimation in stroke survivors enrolled 3 or more months after their event. The primary objective is to test the hypothesis that in stroke survivors, 200mg of modafinil taken once daily for at least 56 days significantly improves participant quality of life compared to placebo, due to the improvement of severe and persisting fatigue after stroke. The trial will screen potential participants with the Multidimensional Fatigue Inventory (MFI) score of above 60. Upon consent and if patient meets other specified inclusion and exclusion criteria they will be randomised to either modafinil (200mg) or placebo once daily for 56 days. The main study visits include screening, Day 0, Day 28 and Day 56 for trial assessments with the SF-36, TMTs, FSS, MoCA, DASS 42 and the EQ5D and mRS. Caregivers will also be compete CSI and OCBS at each study visit The study sample size has been calculated to be 300 recruited participants (150 in each arm). ...
Chronic fatigue syndrome[edit]. A potential use for rituximab was identified by two Norwegian doctors who were treating people ... who had cancer with rituximab; two people also had chronic fatigue syndrome and the CFS improved.[51] As of 2017 this use had ... "Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome". British Journal of ...
May 2006). "A Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome". Journal of Chronic Fatigue ... Chronic Fatigue Syndrome: From Diagnosis to Management CME/CE (pdf). Medscape, LLC. 2008. Retrieved 2009-04-19.. ... Work on chronic fatigue syndrome[edit]. Bell's interest in CFS began in 1985 when an apparent cluster outbreak of 216 persons ... Bell, David (1995). The doctor's guide to chronic fatigue syndrome: understanding, treating, and living with CFIDS. Reading, ...
Exercise and fatigue[edit]. A low-carbohydrate diet has been found to reduce endurance capacity for intense exercise efforts, ...
Alcohol consumption and fatigue[edit]. Sleepiness influences the severity of alcohol consumption. Conditions of sleep ... Levine, M.E., Duffy, L.K., Bowyer, R.T. Fatigue, sleep, and seasonal hormone levels: implications for drinking behavior in ... Increased alcohol consumption during the winter months for Northern climate residents is attributed to escalations in fatigue.[ ...
Fatigue[edit]. Fatigue may be a consequence of the cancer or its treatment, and can last for months to years after treatment. ... "Exercise for the management of cancer-related fatigue in adults". The Cochrane Database of Systematic Reviews. 11: CD006145. ... Franklin DJ, Packel L (Mar 2006). "Cancer-related fatigue". Archives of Physical Medicine and Rehabilitation. 87 (3 Suppl 1): ... Some patients report fatigue or non-specific neurocognitive problems, such as an inability to concentrate; this is sometimes ...
Role in muscular fatigue[edit]. The onset of acidosis during periods of intense exercise is commonly attributed to accumulation ... While LDH activity is correlated to muscle fatigue,[21] the production of lactate by means of the LDH complex works as a system ... From this reasoning, the idea of lactate production being a primary cause of muscle fatigue during exercise has been widely ... Tesch P, Sjödin B, Thorstensson A, Karlsson J (1978). "Muscle fatigue and its relation to lactate accumulation and LDH activity ...
Chronic fatigue[edit]. Chronic fatigue associated with GSE is a systemic disorder, however there are neurological components ... 2005). "Fatigue in adult coeliac disease". Aliment. Pharmacol. Ther. 22 (5): 489-494. doi:10.1111/j.1365-2036.2005.02619.x. ... B12 and malabsorption of essential fatty acids can cause depression and chronic fatigue.[90] Anti-gliadin antibodies correlate ... with higher risk for chronic-fatique when no clinical finding of CD is present.[91] While fatigue is reduced on gluten-free ...
Condom fatigue[edit]. Although HIV transmission rates fell throughout the 1990s, they hit a plateau at the end of the decade. ... 2005): AIDS optimism, condom fatigue, or self-esteem? Explaining unsafe sex among gay and bisexual men, Journal of Sex Research ... and the United Kingdom led to reports in the gay and mainstream media of condom fatigue and "AIDS optimism" as causes of the ...
Exercise fatigue[edit]. L-Ornithine supplementation attenuated fatigue in subjects in a placebo-controlled study using a cycle ... Sugino T, Shirai T, Kajimoto Y, Kajimoto O (November 2008). "L-ornithine supplementation attenuates physical fatigue in healthy ...
Fatigue. *Muscle weakness. *Metastatic calcification of the soft tissues. Symptoms of vitamin D toxicity appear several months ...
Muscle weakness, also known as muscle fatigue, (or "lack of strength") refers to the inability to exert force with one's ... It consists of five domains of the frailty phenotype: •Fatigue •Loss of appetite •Grip strength •Functional difficulties • ...
Fatigue. *Physical illness. It is very uncommon that a neurological examination and blood tests can determine the cause of a ...
... is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into desvenlafaxine, so the effects of the two drugs are expected to be very similar.[5] It works by blocking the "reuptake" transporters for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are serotonin (5-hydroxytryptamine) and norepinephrine (noradrenaline). It is approximately 10 times more potent at inhibiting serotonin uptake than norepinephrine uptake.[6]. ...
Fatigue. *Partial hair loss (by strands, not typically in clumps). Rare[edit]. *interstitial pneumonitis, which is ...
... fatigue; intellectual retardation (possible); skeletal deformities; chest and back (scoliosis); muscle deformities ( ...
Side effects include fatigue and influenza-like symtoms. *Cladribine (CdA). Chemotherapy which is given as subcutaneous ...
Fatigue. *Enlarged and reddened tonsils with yellow or white exudates present (this is typically an exudative pharyngitis)[11] ... The rash begins 1-2 days following the onset of symptoms caused by the strep pharyngitis (sore throat, fever, fatigue).[13] ... This may include fever, fatigue, and sore throat. The characteristic scarlatiniform rash then comes 12-48 hours later. During ...
Fatigue. FSH analogues[edit]. Corifollitropin alfa. Merck received approval on February 15, 2010 from the European Commission ...
It is possible that in untreated patients with CD, neurologic symptoms such as chronic fatigue, inattention, pain, and headache ...
At ASCO 2007, results from the SHARP trial[13] were presented, which showed efficacy of sorafenib in hepatocellular carcinoma. The primary endpoint was median overall survival, which showed a 44% improvement in patients who received sorafenib compared to placebo (hazard ratio 0.69; 95% CI, 0.55 to 0.87; p=0.0001). Both median survival and time to progression showed 3-month improvements; however, there was no significant difference in median time to symptomatic progression (p=0.77). There was no difference in quality of life measures, possibly attributable to toxicity of sorafenib or symptoms related to underlying progression of liver disease. Of note, this trial only included patients with Child-Pugh Class A (i.e. mildest) cirrhosis.[13] Because of this trial Sorafenib obtained FDA approval for the treatment of advanced hepatocellular carcinoma in November 2007.[4] In a randomized, double-blind, phase II trial combining sorafenib with doxorubicin, the median time to progression was not ...
Fatigue. *Nausea, vomiting, or diarrhea. *Neutropenia (low number of a type of white blood cells) ...
See also: central fatigue. Stimulants can have a wide variety of mechanisms. Many stimulants exert their effects through ... Increased muscle strength and delayed muscle fatigue. • Increased acceleration. • Increased alertness and attention to task. ... In low doses, methamphetamine can cause an elevated mood and increase alertness, concentration, and energy in fatigued ... Amphetamines and caffeine are stimulants that increase alertness, improve focus, decrease reaction time, and delay fatigue, ...
Extraintestinal presentations include anemia, osteoporosis, dermatitis herpetiformis, short stature, delayed puberty, fatigue, ... and symptoms include fatigue and weakness. Orthostatic hypotension, a marked decrease in blood pressure when standing from a ...
Avoiding activities which induce fatigue is also important, since those with SLE fatigue easily and it can debilitating. These ... Fatigue in SLE is probably multifactorial and has been related to not only disease activity or complications such as anemia or ... Common initial and chronic complaints include fever, malaise, joint pains, muscle pains, and fatigue. Because these symptoms ... "Fatigue in systemic lupus erythematosus: contributions of disease activity, pain, depression, and perceived social support". J ...
Fatigue (5.2%). *Anemia (5.6%). Rare side effects include:[16]. *Pulmonary embolism. *Deep vein thrombosis ...
Chronic fatigue is part of an even broader category called prolonged fatigue, which is fatigue that lasts for 1 month or more. ... chronic fatigue syndrome falls under the broader category of chronic fatigue, which is defined as unexplained fatigue that ... Chronic fatigue syndrome (CFS). Patients must have a number of specific symptoms -- not just fatigue -- to be diagnosed with ... Chronic fatigue syndrome. Description. An in-depth report on the causes, diagnosis, and treatment of chronic fatigue syndrome. ...
Evidence-based recommendations on diagnosing and managing chronic fatigue syndrome (CFS)/myaligc encephalomyelitis (ME) in ... Chronic fatigue syndrome Chronic fatigue syndrome/myalgic encephalomyelitis (or encephalopathy): diagnosis and management. ... 9] NHS Plus has produced guidance on the occupational aspects of the management of CFS/ME (search for chronic fatigue syndrome ... Identifying the common changes in sleep patterns seen in CFS/ME that may exacerbate fatigue symptoms (such as insomnia, ...
Demonstrated diagnosis chronic fatigue syndrome / myalgic encephalomyelitis may be suitable in patients with suspected side ... You are here: Home / NEWS . . . . . . . . / World News / Europe / Denmark / Chronic Fatigue Syndrome / Myalgic ... As fatigue and fatigability is a prominent symptom in many of the patients with suspected side effects to the vaccine, chronic ... Filed Under: Denmark, Gardasil/Silgard Reactions, HPV vaccine research, ME/CFS Tagged With: chronic fatigue syndrome, Gardasil ...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease with no known cause or mechanism. There is an ... Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations. ... Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations. ... Patients suffer from severe fatigue and postexertional malaise. There is little known about the metabolism of specific immune ...
Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients Sharni Lee Hardcastle✉ ... Keywords: Cytokine, Immunoglobulin, Chronic Fatigue Syndrome, Serum Protein, Inflammation This is an open access article ... Immunological dysregulation is present in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), with recent studies also ... Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients. Int J Med Sci 2015; ...
Characteristics of fatigued persons associated with features of chronic fatigue syndrome. J Chronic Fatigue Syndr 1998;4:71-97. ... Prevalence of fatigue and chronic fatigue syndrome in a primary care practice. Arch Intern Med 1993;153:2759-65. ... Prevalence of chronic fatigue and chronic fatigue syndrome in Korea: community-based primary care study. J Korean Med Sci 2005; ... Fatigue and chronic fatigue syndrome-like complaints in the general population. Eur J Public Health 2010;20:251-7. ...
IOM calls for new chronic fatigue syndrome criteria: Part 3. Take Quiz. ... IOM calls for new chronic fatigue syndrome criteria: Part 2. Take Quiz. ... or severe intensity at least half of the time-is important for distinguishing ME/CFS from other fatiguing disorders that ... Committee on the Diagnostic Criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), the 6-month duration ...
According to researchers, the duration of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in children is similar to ... IOM calls for new chronic fatigue syndrome criteria: Part 3. Take Quiz. ... IOM calls for new chronic fatigue syndrome criteria: Part 2. Take Quiz. ...
Patients report a profound lack of energy, not an ordinary type of fatigue. Characteristics of the disease will be reviewed ... She has a special interest in the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. ...
Myalgic encephalomyelitis, also known as chronic fatigue syndrome or ME/CFS, is a multifactorial and debilitating disease that ... Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue ... Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue ... Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue ...
The respondents were classified as two categories, "high mental fatigue" and "low mental fatigue," based on their responses to ... Overall, the proportion of participants with high mental fatigue was 13.2%. There was no association between the year of survey ... The survey contained a question assessing mental fatigue: "How often do you usually feel mentally tired or depressed?" In total ... Unreliable Information as a Risk Factor for Worse Mental Fatigue among Residents in Fukushima after the Nuclear Power Station ...
Metabolic Analysis of B-Cell Maturation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome December 6, 2016. / volkmedia / ... Metabolic Analysis of B-Cell Maturation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ... News Biomarker discovery biomarkers CFSAC CFS definition CFS education CFS research CFS self-care techniques Chronic Fatigue ... agents have been reported to cause or trigger the symptoms described by patients with Myalgic encephalomyelitis/Chronic Fatigue ...
However, while fatigue is a feature of many common illnesses, it is the main problem in Chronic Fatigue Syndrome/Myalgic ... However, unexplained fatigue and CFS/ME may be confidently diagnosed on the basis of specific clinical criteria combined with ... Unexplained fatigue is not infrequent in the community. It presents a number of challenges to the primary care physician and ... criteria that best confirms CFS/ME to the exclusion of other medical and psychiatric/psychological causes of chronic fatigue. ...
Cornell University have finally shed light on the biological markers associated with Myalgic Encephalomyelitis/Chronic Fatigue ... What is Chronic Fatigue Syndrome?. Chronic Fatigue Syndrome is a complex and often debilitating disorder characterized by ... The Article Researchers Connect Chronic Fatigue Syndrome to Gut Bacteria Imbalance was originally published on the Isotrope ... Researchers Connect Chronic Fatigue Syndrome to Gut Bacteria Imbalance. isotropeusa Uncategorized July 17, 2017. July 17, 2017 ...
An Etiological Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.. Jason LA, Sorenson M, Porter N, Belkairous N. ... Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome ...
HealthDay)-Neuroinflammation markers are elevated in the brains of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) ...
If endometriosis is causing you to experience symptoms like fatigue, know that you arent alone. Heres what you can do to help ... Accepting that fatigue may impact your day is key. For Jessica, that fatigue usually sets in around 6 pm. For you, it may be a ... Can I Be Tested for Adrenal Fatigue?. Some healthcare providers subscribe to the theory of a condition known as adrenal fatigue ... Endometriosis Fatigue: Why It Happens and What You Can Do. Medically reviewed by Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC ...
Find out about some of the common and uncommon causes of fatigue and how to help yourself. ... One disorder that causes extreme fatigue is chronic fatigue syndrome (CFS). This fatigue is not the kind of tired feeling that ... Fatigue (PDQ) (National Cancer Institute) Also in Spanish * Fatigue and Multiple Sclerosis (National Multiple Sclerosis Society ... Fatigue Fighters in Sjogrens Syndrome (Sjogrens Syndrome Foundation) - PDF * Is Fatigue a Common Crohns Disease Symptom? ...
Chronic Fatigue Syndrome is a chronic illness characterized by extreme fatigue that lasts for more than six months. Heres the ... Causes of Chronic Fatigue Syndrome. We still know very little about chronic fatigue, and sadly, the cause is still unknown. ... Chronic Fatigue Syndrome is a chronic illness characterized by extreme fatigue that lasts for more than six months. This ... Chronic Fatigue Syndrome Symptoms. While the term "chronic fatigue" is fairly descriptive of this crippling illness, it doesnt ...
This can include establishing a Fatigue Risk Management Plan or strategies for fatigue mitigation on the job. Share and ensure ... can lead to poor sleep and extreme fatigue. Fatigue increases the risk for injury and deteriorating health (infections, ... Do not work if your fatigue threatens the safety of yourself or others. Report to a manager when you feel too tired to work ... The Epworth Sleepiness Scale is a short survey that can be posted in a common area for workers to quickly rate their fatigue. ...
Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a debilitating disorder linked to diverse intracellular ... Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a debilitating disorder linked to diverse intracellular ... Myalgic encephalomyelitis/chronic fatigue syndrome. J Chronic Fatigue Syndr (2003) 11(1):7-115. doi:10.1300/J092v11n01_02 ... Psychobehavioral and immunological characteristics of adult people with chronic fatigue and patients with chronic fatigue ...
Listener fatigue (also known as listening fatigue or ear fatigue) is a phenomenon that occurs after prolonged exposure to an ... Long-term fatigue[edit]. Long-term fatigue is defined as full recovery from temporary threshold shifts taking at least several ... Listener fatigue is not a clinically recognized state, but is a term used by many professionals. The cause for listener fatigue ... Temporary threshold shifts can result in different types of fatigue. Short-term fatigue[edit]. Recovery from temporary ...
Static fatigue is also found in this embrittlement form, such as the moisture-enhanced static fatigue of glass,[3] hydrogen ... It is often manifested by static fatigue. For example, as shown in Figure 1,[2] in a test of the static fatigue of a 2024 ... Furthermore, the static fatigue limit is observed. Kinetics[edit]. The strength vs. temperature plot of glass exposed in air is ... Static fatigue describes the fracture happening at a stress level less than the value required to cause ordinary tensile ...
Muscle fatigue, for example, results when the contractile properties of muscle are reduced, and continued exertion is ... fatigue. fatigue, in physiology, inability to perform reasonable and necessary physical or mental activity. Muscle fatigue, for ... If excessive fatigue occurs over a prolonged period, exhaustion (marked loss of vital and nervous power) may result. In most ... A new explanation of muscle fatigue suggests that it is related to the control of the flow of the calcium ions in muscle. The ...
In order to help pilots avoid flying fatigued, NIOSH recently completed a fatigue prevention training for commercial pilots in ... Fatigue is a general lack of alertness and degradation in mental and physical performance, and can affect pilot alertness, ... Pilot fatigue has been documented as early as 1927 when Charles Lindbergh crossed the Atlantic Ocean. The National ... The training can be downloaded here: Fatigue Prevention for Pilots: A Training Program for Commercial Pilots in Alaska ...
  • It affects up to one-fifth of all Americans at some point in their lives, and most depressed people feel fatigued. (umm.edu)
  • From the 1930s through the 1950s, outbreaks of disease marked by prolonged fatigue were reported in the United States and many other countries. (umm.edu)
  • However, unexplained fatigue and CFS/ME may be confidently diagnosed on the basis of specific clinical criteria combined with the normality of routine blood tests. (biomedcentral.com)
  • A simple clinical scoring system and a short list of routine investigations should help discriminate CFS/ME from other causes of continued fatigue. (biomedcentral.com)
  • Unreliable Information as a Risk Factor for Worse Mental Fatigue among Residents in Fukushima after the Nuclear Power Station Accident. (bvsalud.org)
  • We explored the association between information sources regarding reconstruction progress after the disaster and mental fatigue in Fukushima. (bvsalud.org)
  • The respondents were classified as two categories, "high mental fatigue " and "low mental fatigue ," based on their responses to this question. (bvsalud.org)
  • There was no association between the year of survey or occupation and high mental fatigue . (bvsalud.org)
  • Then, we conducted a cross-sectional analysis of the associations between clusters of information sources and high mental fatigue . (bvsalud.org)
  • We found that unreliable information sources, such as " Internet " and "a combination of TV, radio , and word of mouth ," were significantly associated with high mental fatigue , compared with reliable information sources, such as "municipal public relations in addition to major media (newspaper, TV, and radio ). (bvsalud.org)
  • These findings provide important insights into how information sources affect mental fatigue following a disaster. (bvsalud.org)
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