Factor x. Medical search

Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.

Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.

Activated form of factor IX. This activation can take place via the intrinsic pathway by the action of factor XIa and calcium, or via the extrinsic pathway by the action of factor VIIa, thromboplastin, and calcium. Factor IXa serves to activate factor X to Xa by cleaving the arginyl-leucine peptide bond in factor X.

Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).

Activated form of factor VII. Factor VIIa activates factor X in the extrinsic pathway of blood coagulation.

Absence or reduced levels of PROTHROMBIN in the blood.

Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.

A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.

Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.

Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. The activated form then catalyzes the activation of factor X to factor Xa.

The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.

Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.

Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.

Endogenous substances, usually proteins, that are involved in the blood coagulation process.

A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.

Laboratory tests for evaluating the individual's clotting mechanism.

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.

Solutions or mixtures of toxic and nontoxic substances elaborated by snake (Ophidia) salivary glands for the purpose of killing prey or disabling predators and delivered by grooved or hollow fangs. They usually contain enzymes, toxins, and other factors.

Dysprosium. An element of the rare earth family that has the atomic symbol Dy, atomic number 66, and atomic weight 162.50. Dysprosium is a silvery metal used primarily in the form of various salts.

Agents that cause clotting.

Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.

The rate dynamics in chemical or physical systems.

Activated form of factor V. It is an essential cofactor for the activation of prothrombin catalyzed by factor Xa.

A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.

The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.

Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.

Ytterbium. An element of the rare earth family of metals. It has the atomic symbol Yb, atomic number 70, and atomic weight 173. Ytterbium has been used in lasers and as a portable x-ray source.

Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.

An autosomal recessive characteristic or a coagulation disorder acquired in association with VITAMIN K DEFICIENCY. FACTOR VII is a Vitamin K dependent glycoprotein essential to the extrinsic pathway of coagulation.

The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in human and other male-heterogametic species.

An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

Samarium. An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.

The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.

A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.

Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa in the presence of cofactor HMWK; (HIGH MOLECULAR WEIGHT KININOGEN). Factor XIa then activates factor IX to factor IXa in the presence of calcium.

Amidines substituted with a benzene group. Benzamidine and its derivatives are known as peptidase inhibitors.

A family of snakes comprising three subfamilies: Azemiopinae (the mountain viper, the sole member of this subfamily), Viperinae (true vipers), and Crotalinae (pit vipers). They are widespread throughout the world, being found in the United States, Central and South America, Europe, Asia and Africa. Their venoms act on the blood (hemotoxic) as compared to the venom of elapids which act on the nervous system (neurotoxic). (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, pp333-36)

Limbless REPTILES of the suborder Serpentes.

Proteins prepared by recombinant DNA technology.

Agents that prevent clotting.

Evidence suggesting the regulation of a coagulation factor levels in rabbits by a transferable plasma agent. (1/674)

New Zealand white rabbits were given 30 ml of goat serum intravenously. This procedure resulted in an immediate decrease in platelet count, fibrinogen, and levels of coagulation factors II, V, VII, and X, due to consumption coagulopathy. These factors returned toward baseline levels approximately 12 hr after the injection. Plasma from rabbits who had received goat serum 48 hr previously (donor rabbits) was injected into recipient rabbits. This procedure resulted in a slight rise in the level of coagulation factor II (range, 20%-30%) and a significant rise in factors V (35%-75%), VII (35%-235%), and X (35%-75%) in the recipients. When plasma from control donor rabbits who had not received goat serum was injected into recipients, there was no change in these coagulation factors. It is postulated that the reduction in coagulation factor levels in donor rabbits induces a "coagulopoietin" for each factor or one "coagulopoietin" for all factors which stimulates increased synthesis and/or release of these factors in recipient rabbits. (+info)

Plasmin converts factor X from coagulation zymogen to fibrinolysis cofactor. (2/674)

Known anticoagulant pathways have been shown to exclusively inhibit blood coagulation cofactors and enzymes. In the current work, we first investigated the possibility of a novel anticoagulant mechanism that functions at the level of zymogen inactivation. Utilizing both clotting and chromogenic assays, the fibrinolysis protease plasmin was found to irreversibly inhibit the pivotal function of factor X (FX) in coagulation. This was due to cleavage at several sites, the location of which were altered by association of FX with procoagulant phospholipid (proPL). The final products were approximately 28 and approximately 47 kDa for proPL-bound and unbound FX, respectively, which did not have analogues when activated FX (FXa) was cleaved instead. We next investigated whether the FX derivatives could interact with the plasmin precursor plasminogen, and we found that plasmin exposed a binding site only on proPL-bound FX. The highest apparent affinity was for the 28-kDa fragment, which was identified as the light subunit disulfide linked to a small fragment of the heavy subunit (Met-296 to approximately Lys-330). After cleavage by plasmin, proPL-bound FX furthermore was observed to accelerate plasmin generation by tissue plasminogen activator. Thus, a feedback mechanism localized by proPL is suggested in which plasmin simultaneously inhibits FX clotting function and converts proPL-bound FX into a fibrinolysis cofactor. These data also provide the first evidence for an anticoagulant mechanism aimed directly at the zymogen FX. (+info)

Coagulation factors II, V, VII, and X, prothrombin gene 20210G-->A transition, and factor V Leiden in coronary artery disease: high factor V clotting activity is an independent risk factor for myocardial infarction. (3/674)

Increased levels of hemostatic factors and genetic mutations of proteins involved in coagulation may play a role in the pathogenesis of coronary artery disease. We investigated clotting activity of factors II (FII:C), V (FV:C), VII (FVII:C), and X (FX:C), the prothrombin gene 20210G-->A transition, and the factor V Leiden mutation in 200 survivors of myocardial infarction and in 100 healthy controls. FV:C (P<0.0001) and FVII:C (P<0.0001) were found to be independent risk factors for myocardial infarction. High FV:C or high FVII:C combined with smoking or arterial hypertension increased the relative risk for myocardial infarction up to 50-fold. One of 177 patients (0.6%) and 4 of 89 controls (4.5%) had the prothrombin 20210 AG genotype. Eleven of 177 patients (6.2%) and 6 of 89 controls (6.7%) were heterozygous for the factor V Leiden mutation. No homozygous carrier for these mutations was found. Neither the prothrombin gene 20210G-->A transition (odds ratio [OR], 0.1; 95% confidence interval [CI], 0.01 to 1.1) nor the factor V Leiden mutation (OR, 1.0; 95% CI, 0.4 to 2.8) were associated with an increased relative risk for myocardial infarction. In conclusion, our data indicate that neither the prothrombin gene 20210G-->A transition nor the factor V Leiden mutation are risk factors for myocardial infarction. High FVII:C was confirmed to be an independent risk factor for myocardial infarction. Moreover, we describe for the first time that high FV:C is an independent risk factor for myocardial infarction. (+info)

Domain identification of hormone-sensitive lipase by circular dichroism and fluorescence spectroscopy, limited proteolysis, and mass spectrometry. (4/674)

Structure-function relationship analyses of hormone-sensitive lipase (HSL) have suggested that this metabolically important enzyme consists of several functional and at least two structural domains (Osterlund, T., Danielsson, B., Degerman, E., Contreras, J. A., Edgren, G., Davis, R. C., Schotz, M. C., and Holm, C. (1996) Biochem. J. 319, 411-420; Contreras, J. A., Karlsson, M., Osterlund, T., Laurell, H., Svensson, A., and Holm, C. (1996) J. Biol. Chem. 271, 31426-31430). To analyze the structural domain composition of HSL in more detail, we applied biophysical methods. Denaturation of HSL was followed by circular dichroism measurements and fluorescence spectroscopy, revealing that the unfolding of HSL is a two-step event. Using limited proteolysis in combination with mass spectrometry, several proteolytic fragments of HSL were identified, including one corresponding exactly to the proposed N-terminal domain. Major cleavage sites were found in the predicted hinge region between the two domains and in the regulatory module of the C-terminal, catalytic domain. Analyses of a hinge region cleavage mutant and calculations of the hydropathic pattern of HSL further suggest that the hinge region and regulatory module are exposed parts of HSL. Together, these data support our previous hypothesis that HSL consists of two major structural domains, encoded by exons 1-4 and 5-9, respectively, of which the latter contains an exposed regulatory module outside the catalytic alpha/beta-hydrolase fold core. (+info)

The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity. (5/674)

Factor VIIIa, the protein cofactor for factor IXa, is comprised of A1, A2, and A3-C1-C2 subunits. Recently, we showed that isolated A2 subunit enhanced the kcat for factor IXa-catalyzed activation of factor X by approximately 100-fold ( approximately 1 min-1), whereas isolated A1 or A3-C1-C2 subunits showed no effect on this rate (Fay, P. J., and Koshibu, K. J. (1998) J. Biol. Chem. 273, 19049-19054). However, A1 subunit increased the A2-dependent stimulation by approximately 10-fold. The Km for factor X in the presence of A2 subunit was unaffected by A1 subunit, whereas the kcat observed in the presence of saturating A1 and A2 subunits ( approximately 15 min-1) represented 5-10% of the value observed for native factor VIIIa (approximately 200 min-1). An anti-A1 subunit antibody that blocks the association of A2 eliminated the A1-dependent contribution to factor IXa activity. Inclusion of both A1 and A2 subunits resulted in greater increases in the fluorescence anisotropy of fluorescein-Phe-Phe-Arg factor IXa than that observed for A2 subunit alone and approached values obtained with factor VIIIa. These results indicate that A1 subunit alters the A2 subunit-dependent modulation of the active site of factor IXa to synergistically increase cofactor activity, yielding an overall increase in kcat of over 1000-fold compared with factor IXa alone. (+info)

Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage. (6/674)

Agents that restore vascular patency in stroke also increase the risk of intracerebral hemorrhage (ICH). As Factor IXa is a key intermediary in the intrinsic pathway of coagulation, targeted inhibition of Factor IXa-dependent coagulation might inhibit microvascular thrombosis in stroke without impairing extrinsic hemostatic mechanisms that limit ICH. A competitive inhibitor of native Factor IXa for assembly into the intrinsic Factor X activation complex, Factor IXai, was prepared by covalent modification of the Factor IXa active site. In a modified cephalin clotting time assay, in vivo administration of Factor IXai caused a dose-dependent increase in time to clot formation (3.6-fold increase at the 300 micrograms/kg dose compared with vehicle-treated control animals, P < 0.05). Mice given Factor IXai and subjected to middle cerebral artery occlusion and reperfusion demonstrated reduced microvascular fibrin accumulation by immunoblotting and immunostaining, reduced 111In-labeled platelet deposition (42% decrease, P < 0.05), increased cerebral perfusion (2.6-fold increase in ipsilateral blood flow by laser doppler, P < 0.05), and smaller cerebral infarcts than vehicle-treated controls (70% reduction, P < 0.05) based on triphenyl tetrazolium chloride staining of serial cerebral sections. At therapeutically effective doses, Factor IXai was not associated with increased ICH, as opposed to tissue plasminogen activator (tPA) or heparin, both of which significantly increased ICH. Factor IXai was cerebroprotective even when given after the onset of stroke, indicating that microvascular thrombosis continues to evolve (and may be inhibited) even after primary occlusion of a major cerebrovascular tributary. (+info)

Dietary lipid lowering reduces tissue factor expression in rabbit atheroma. (7/674)

BACKGROUND: The mechanisms by which lipid lowering reduces the incidence of acute thrombotic complications of coronary atheroma in clinical trials remains unknown. Tissue factor (TF) overexpressed in atheroma may accelerate thrombus formation at the sites of plaque disruption. A cell surface cytokine CD40 ligand (CD40L) enhances TF expression in vitro. METHODS AND RESULTS: To test the hypothesis that lipid lowering reduces TF expression and activity, we produced atheroma in rabbit aortas by balloon injury and cholesterol feeding for 4 months (Baseline group, n=15), followed by either a chow diet (Low group, n=10) or a continued high-cholesterol diet for 16 months (High group, n=5). Immunolocalization of TF, CD40L, and its receptor CD40 was quantified by computer-assisted color image analysis. Macrophages in atheroma of the Baseline and High groups strongly expressed TF. Intimal smooth muscle cells and endothelial cells also contained immunoreactive TF. Regions of expression of CD40L and CD40 colocalized with TF. Protein expression of TF diminished substantially in the Low group in association with reduced expression of CD40L and CD40. In situ binding of TF to factors VIIa and X, detected by digoxigenin-labeled factors VIIa and X, colocalized with TF protein in atheroma and decreased after lipid lowering. We also determined reduced TF biological activity in the Low group by use of a chromogenic assay. The level of TF mRNA detected by reverse transcription-polymerase chain reaction also decreased after lipid lowering. CONCLUSIONS: These results suggest decreased expression and activity of TF as a novel mechanism of reduced incidence of thrombotic complications of atherosclerosis by lipid lowering. (+info)

"Normal" thrombin generation. (8/674)

We have investigated the influence of alterations in plasma coagulation factor levels between 50% and 150% of their mean values for prothrombin, factor X, factor XI, factor IX, factor VII, factor VIII, factor V, protein C, protein S, antithrombin III (AT-III), and tissue factor pathway inhibitor (TFPI) as well as combinations of extremes, eg, 50% anticoagulants and 150% procoagulants or 50% procoagulants and 150% anticoagulants in a synthetic "plasma" system. The reaction systems were constructed in vitro using purified, natural, and recombinant proteins and synthetic phospholipid vesicles or platelets with the reactions initiated by recombinant tissue factor (TF)-factor VIIa complex (5 pmol/L). To investigate the influence of the protein C system, soluble thrombomodulin (Tm) was also added to the reaction mixture. For the most extreme situations in which the essential plasma procoagulants (prothrombin, and factors X, IX, V, and VIII) and the stoichiometric anticoagulants (AT-III and TFPI) were collectively and inversely altered by 50%, a 28-fold difference in the total available thrombin generated was observed. Variations of most of these proteins 50% above and below the "normal" range, with the remainder at 100%, had only modest influences on the peak and total levels of thrombin generated. The dominant factors influencing thrombin generation were prothrombin and AT-III. When these 2 components were held at 100% and all other plasma procoagulants were reduced to 50%, there was a 60% reduction in the available thrombin generated. No increase in the thrombin generated was observed when the 150% level of all plasma procoagulants other than prothrombin was evaluated. When only prothrombin was raised to 150%, and all other factors were maintained at 100%, the thrombin generated increased by 71% to 121%. When AT-III was at 50% and all other constituents were at 100%, thrombin production was increased by 104% to 196%. The additions of protein C and protein S over the 50% to 150% ranges with Tm at 0.1 nmol/L concentration had limited influence on thrombin generation. Individual variations in factors VII, XI, and X concentrations had little effect on the duration of the initiation phase, the peak thrombin level achieved, or the available thrombin generated. Paradoxically, increases in factor IX concentration to 150% led to lowered thrombin generation, while decreases to 50% led to enhanced thrombin generation, most likely a consequence of factor IX as a competitive substrate with factor X for factor VIIa-TF. Reductions in factor V or factor VIII concentration led to prolongations of the initiation phase, while the reduction of TFPI to 50% led to shortening of this phase. However, none of these alterations led to significant changes in the available thrombin generated. Based on these data, one might surmise that increases in prothrombin and reductions in AT-III, within the normal range, would be potential risk factors for thrombosis and that algorithms that combine normal factor levels may be required to develop predictive tests for thrombosis. (+info)

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Ben Blish, Damping Factor Audioholics. AV University. Amplifier Technology. Dick Pierce, Damping factor: Effects on System ... damping factor is about 0.37 dB. However, the amplifier with the low damping factor is acting more like a graphic equaliser ... will tend to have damping factors closer to unity, or even less than 1 (very low damping factor/high output impedance ... Damping factor with an 8 Ω load becomes more than 50 when this control is set to NORMAL. Likewise, it is 5 at MEDIUM position, ...

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... or fibrin stabilizing factor is a zymogen found in blood of humans and some other animals. It is activated by ... Factor XIII is a transglutaminase that circulates in human blood as a heterotetramer of two A and two B subunits. Factor XIII ... Factor XIII Deficiency is also known as Laki-Lorand factor, after Kalman Laki and Laszlo Lorand, the scientists who first ... "Factor XIII: a coagulation factor with multiple plasmatic and cellular functions". Physiological Reviews. 91 (3): 931-72. doi: ...

https://en.wikipedia.org/wiki/Factor_XIII

... the phase factor is the complex exponential factor (eiθ). As such, the term "phase factor" is related to the more general term ... Multiplying the equation of a plane wave Aei(k·r − ωt) by a phase factor shifts the phase of the wave by θ: e i θ A e i ( k ⋅ r ... In optics, the phase factor is an important quantity in the treatment of interference. Berry phase Bra-ket notation Euler's ... However, differences in phase factors between two interacting quantum states can sometimes be measurable (such as in the Berry ...

https://en.wikipedia.org/wiki/Phase_factor

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Mainly taken from risk factors for breast cancer, risk factors can be described in terms of, for example: Relative risk, such ... The term "risk factor" was coined by former Framingham Heart Study Director, Dr. William B. Kannel in a 1961 article in Annals ... Risk Factors. ISBN 1-55009-113-1. Retrieved 27 January 2011. Giordano SH, Cohen DS, Buzdar AU, Perkins G, Hortobagyi GN (July ... This example of a risk factor is described in terms of the relative risk it confers, which is evaluated by comparing the risk ...

https://en.wikipedia.org/wiki/Risk_factor

The branching factor can be cut down by a pruning algorithm. The average branching factor can be quickly calculated as the ... Chess's branching factor is 35. Go's is 250. Games with high branching factors make classic search algorithms like minimax ... By comparison, the average branching factor for the game Go is 250. Higher branching factors make algorithms that follow every ... For example, in chess, if a "node" is considered to be a legal position, the average branching factor has been said to be about ...

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... is a moth in the family Gelechiidae.[failed verification] It is found in North America, where it has been ...

https://en.wikipedia.org/wiki/Chionodes_factor

... factor XII, factor XI, and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds ... Factor IXa, in turn, forms a complex with Factor VIIIa (FIXa-FVIIIa) and activates factor X. Physiological inhibitors of factor ... "Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ... The zymogen factor is activated into factor XIa by factor XIIa (FXIIa), thrombin, and FXIa itself; due to its activation by ...

https://en.wikipedia.org/wiki/Factor_XI

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On Unix, Plan 9, and Unix-like computer systems, factor is a utility for factoring an integer into its prime factors. factor ... In 2008, GNU factor started to use the GNU MP library for arbitrary-precision arithmetic, allowing it to factor integers of any ... GNU's factor manual page FreeBSD's factor man page (Unix software, Plan 9 commands). ... factor [number] The command can be used by supplying an integer value. Various projects, including simple ones such as printing ...

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Look up form factor in Wiktionary, the free dictionary. Form factor or form-factor may refer to: Form factor (design), an ... or atomic scattering factor, a measure of the amplitude of a wave scattered from an isolated atom Electric form factor, the ... or view factor, the proportion of energy transmitted by that object which can be transferred to another object Form factor in ... Computer form factor, the specifications of computer motherboards Hard disk drive form factor FormFactor (company), a ...

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https://en.wikipedia.org/wiki/John_Factor

ISBN 0-9647938-4-9. BayesFactor -an R package for computing Bayes factors in common research designs Bayes factor calculator - ... the Bayes factor is equal to the ratio of the posterior probabilities of M1 and M2. If instead of the Bayes factor integral, ... Online calculator for informed Bayes factors Bayes Factor Calculators -web-based version of much of the BayesFactor package ( ... The Bayes factor can be thought of as a Bayesian analog to the likelihood-ratio test, but since it uses the (integrated) ...

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... is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as ... The result is a Factor VIIa/TF complex, which catalyzes the activation of Factor X and Factor IX. Factor Xa formed on the ... Factor XIa activates free Factor IX on the surface of activated platelets. The activated Factor IXa with Factor VIIIa forms the ... And they may be more effective against Factor Xa in that they inhibit both free Factor Xa and Factor Xa in the prothrombinase ...

https://en.wikipedia.org/wiki/Factor_X

If repeated attempts to factor fail we can try again using a different factor base. Factor bases are used in, for example, ... has all of its prime factors in the pre-chosen factor base. We represent each x 2 ( mod n ) {\displaystyle x^{2}{\pmod {n}}} ... can be completely factorized over the chosen factor base-that is, all their prime factors are in P. In practice, several ... expression as a vector of a matrix with integer entries being the exponents of factors in the factor base. Linear combinations ...

https://en.wikipedia.org/wiki/Factor_base

... is greatest at high angles of attack and high power, for example during take-off or in slow flight. If using a ... P-factor is insignificant during the initial ground roll, but will give a pronounced nose-left tendency during the later stages ... P-factor, also known as asymmetric blade effect and asymmetric disc effect, is an aerodynamic phenomenon experienced by a ... However, if both engines rotate in the same direction, or if one engine fails, P-factor will cause a yaw. As with single-engine ...

https://en.wikipedia.org/wiki/P-factor

... while velocity factor is used for the ratio. Velocity factor is an important characteristic of communication media such as ... The velocity factor for a lossless transmission line is given by: V F = 1 c 0 L ′ C ′ {\displaystyle \mathrm {VF} ={\frac {1}{c ... The velocity factor (VF), also called wave propagation speed or velocity of propagation (VoP or v P {\displaystyle v_{\mathrm { ... The speed of radio signals in vacuum, for example, is the speed of light, and so the velocity factor of a radio wave in vacuum ...

https://en.wikipedia.org/wiki/Velocity_factor

The other factors that can reduce the winding factor are pitch factor k p {\displaystyle k_{p}} and skew factor k s {\ ... is the distribution factor. k p {\displaystyle k_{p}} is the pole factor. k s {\displaystyle k_{s}} is the skew factor ... Most of 3-phase motors have winding factor values between 0.85 and 0.95. The winding factor (along with some other factors like ... Winding factor also applies to other electric machines, but this article focuses on winding factor as it applies to alternators ...

https://en.wikipedia.org/wiki/Winding_factor

... dividing by the integrating factor on both sides to achieve the final result. A third order usage of integrating factors gives ... Integrating factors are useful for solving ordinary differential equations that can be expressed in the form y ′ + P ( x ) y = ... An integrating factor is any expression that a differential equation is multiplied by to facilitate integration. For example, ... To derive this, let M ( x ) {\displaystyle M(x)} be the integrating factor of a first order linear differential equation such ...

https://en.wikipedia.org/wiki/Integrating_factor

These factors consist of certain cell surface proteins and transcription factors that induce the uptake of DNA. Natural ... All cellular components that are involved in sensing extracellular factors affect the srfA operon. The expression of srfA will ... When this reading frame is expressed, it will activate the transcription factor ComK. After ComK is activated, transcription of ... Golz, Julia C (21 September 2021). ""Take It or Leave It"-Factors Regulating Competence Development and DNA Uptake in ...

https://en.wikipedia.org/wiki/Competence_factor

In algebra, the factor theorem is a theorem linking factors and zeros of a polynomial. It is a special case of the polynomial ... The factor theorem states that a polynomial f ( x ) {\displaystyle f(x)} has a factor ( x − α ) {\displaystyle (x-\alpha )} if ... Use the factor theorem to conclude that ( x − a ) {\displaystyle (x-a)} is a factor of f ( x ) {\displaystyle f(x)} . Compute ... is factored completely, which its all factors is irreducible on R [ x ] {\displaystyle \mathbb {R} [x]} or C [ x ] {\ ...

https://en.wikipedia.org/wiki/Factor_theorem

... (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII ... It is a cofactor to factor IXa in the activation of factor X, which, in turn, with its cofactor factor Va, activates more ... The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. ... the incidence of these inhibitors is dependent of various factors, including the factor VIII product itself. Factor VIII ...

https://en.wikipedia.org/wiki/Factor_VIII

The crop factor is sometimes referred to as "magnification factor", "focal length factor" or "focal length multiplier". This ... Since crop factor is inversely proportional to the square root of sensor area (to within a small aspect ratio-dependent factor ... In digital photography, the crop factor, format factor, or focal length multiplier of an image sensor format is the ratio of ... crop factors. The larger sensor has the smaller crop factor and the higher signal-to-noise ratio. Most SLR camera and lens ...

https://en.wikipedia.org/wiki/Crop_factor

Learn more about stroke risk factors from the CDC. ... Stroke risk factors include age and behaviors such as smoking. ... Genetic factors likely play some role in high blood pressure, stroke, and other related conditions. Several genetic disorders ... Trends in stroke hospitalizations and associated risk factors among children and young adults, 1995-2008. Annals of Neurology. ... People with a family history of stroke are also likely to share common environments and other potential factors that increase ...

https://www.cdc.gov/stroke/risk_factors.htm

Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase ... The factor V Leiden mutation does not itself cause any symptoms. Since factor V Leiden is a risk for developing blood clots in ... Risk factors. A family history of factor V Leiden increases your risk of inheriting the disorder. The disorder is most common ... Both men and women can have factor V Leiden. Women who carry the factor V Leiden mutation may have an increased tendency to ...

https://www.mayoclinic.org/diseases-conditions/factor-v-leiden/symptoms-causes/syc-20372423

Factor X deficiency is a rare bleeding disorder that varies in severity among affected individuals. Explore symptoms, ... The inherited form of factor X deficiency, known as congenital factor X deficiency, is caused by mutations in the F10 gene, ... Factor X deficiency: clinical manifestation of 102 subjects from Europe and Latin America with mutations in the factor 10 gene ... Some F10 gene mutations that cause factor X deficiency reduce the amount of coagulation factor X in the bloodstream, resulting ...

https://medlineplus.gov/genetics/condition/factor-x-deficiency/

Inherited or acquired deficiencies in factor V are rare causes of bleeding disorders. ... Factor V is an essential component in the blood coagulation cascade. ... Familial coagulation factor V deficiency caused by a novel 4 base pair insertion in the factor V gene: factor V Stanford. ... encoded search term (Factor V Deficiency) and Factor V Deficiency What to Read Next on Medscape ...

https://www.medscape.com/answers/209492-185407/what-are-the-differential-diagnoses-for-factor-v-deficiency

Risk Factor Assessment Tools. Falls are due to many factors, and a holistic approach to the individual and environment is ... Well supported tool that identifies risk factors and creates a risk profile score. Used to identify clinical fall risk factors ... The MFS requires systematic, reliable assessment of a clients fall risk factors upon admission, after a fall, with a change in ... A number of assessment tools are readily available to identify adults fall risk factors. Several tools can be used with ...

http://www.mnfallsprevention.org/professional/assessmenttools.html

https://www.medscape.com/answers/209492-184852/what-is-the-role-of-medications-in-the-treatment-of-factor-v-deficiency

An international collaborative study to establish the 2nd international standard for activated factor IX (‎FIXa)‎ ...

https://apps.who.int/iris/browse?authority=Factor+IXa&type=mesh

Factor X deficiency is a bleeding disorder that can be inherited or acquired. ... or Stuart-Prower factor, is a vitamin K-dependent serine protease that serves as the first enzyme in the common pathway of ... Factor X Debrecen: Gly204Arg mutation in factor X causes the synthesis of a non-secretable protein and severe factor X ... One missense mutation in the factor X gene causing factor X deficiency--factor X Kanazawa. Int J Hematol. 2001 Apr. 73(3):390-2 ...

https://emedicine.medscape.com/article/209867-differential

Gothamist is a non-profit local newsroom, powered by WNYC.

https://gothamist.com/news/the-bill-clinton-factor

Risk Factors for Type 2 Violence Unit 4: Risk Factors for Type 3 Violence Unit 5: Prevention Strategies for Organizations Unit ... Unit 4: Risk Factors for Type 3 Violence Workplace Violence Prevention for Nurses About This Course Unit 1: Definitions, Types ... Contributing Factors. The Joint Commission has acknowledged that "intimidating and disruptive behaviors" among co-workers in ... "Systemic factors stem from the unique health care cultural environment, which is marked by pressures that include increased ...

https://wwwn.cdc.gov/WPVHC/Nurses/Course/Slide/Unit4_5

What is an important factor to consider before deciding whether or not to give them one? Why is this factor so important?" ... 10 Key Factors in Determining Whether an Employee Should Get a Raise. Published: May 28, 2020 Last Updated: Aug 23, 2022 by The ... Look at these factors to determine if they should get a raise." ~ John Rampton, Calendar ... but there are other factors to consider as well. Thats why we asked 10 entrepreneurs from Young Entrepreneur Council (YEC) the ...

https://smallbiztrends.com/2020/05/10-reasons-to-give-employees-a-raise.html

Get the latest power factor correction info from our tech-obsessed editors with breaking news, in-depth reviews, hands-on ...

https://www.engadget.com/tag/power%20factor%20correction/

Charlie Demerjian is the founder of Stone Arch Networking Services and S,A. SemiAccurate.com is a technology news site; addressing hardware design, software selection, customization, security and maintenance, with over one million views per month. He is a technologist and analyst specializing in semiconductors, system and network architecture.. As head writer of SemiAccurate.com, he regularly advises writers, analysts, and industry executives on technical matters and long lead industry trends. Charlie is also available through Guidepoint and Mosaic.. Thomas Ryan is a GIS Programmer and freelance technology writer from Seattle, WA. You can find his work on SemiAccurate and PCWorld.. ...

https://semiaccurate.com/tag/form-factor/

Account for these factors when estimating site-specific doses. In addition, some people, such as asthmatics or the elderly, ... Before excluding a contaminant from further evaluation, be sure to consider these other factors:. *Community concerns. As ... The In-Depth Toxicological Effects Analysis section expands on how you should weigh these factors in your evaluation of site ... This section explains the other factors health assessors need to consider during the EPC and exposure calculation process ...

https://www.atsdr.cdc.gov/pha-guidance/conducting_scientific_evaluations/epcs_and_exposure_calculations/other_factors.html

View Dell OptiPlex 3000 Desktop Small Form Factor desktop computer with new Hybrid Core technology or shop all Dell Optiplex ... Model: 3000 Small Form Factor EXPLORE OTHER MODELS 3000 Micro 3000 Small Form Factor 3000 Thin Client 3000 Tower 3090 Ultra ... Small Form Factor:. Front: 2 USB 2.0 ports. 2 USB 3.2 Gen 1 ports. 1 universal audio jack. Rear:. 2 USB 3.2 Gen 1 ports. 2 USB ... Small Form Factor:. 1 half-height Gen 4 PCIe x16 slot. 1 half-height Gen 3 PCIe x1 slot. 1 M.2 2230 slot for WiFi and Bluetooth ...

https://www.dell.com/en-us/shop/desktops-all-in-one-pcs/new-optiplex-3000-small-form-factor/spd/optiplex-3000-sff/s011do3000sffus

Ariat International

https://www.ariat.com/gb/en/P15583_NA_ACC.html?dwvar_P15583__NA__ACC_color=DEEP_NAVY

Factor became a United States citizen in 1916. In 1920, Max Factor gave in to Frank Factors suggestion, and officially began ... Davis Factor (February 2, 1902 - August 31, 1991). *Francis "Frank" Factor (later known as Max Factor Jr.; August 18, 1904 - ... "Max Factor House , Los Angeles Conservancy". www.laconservancy.org. Retrieved 2018-11-19. Factor, born to a Jewish family in ... Additionally, Max Factor is honored with a star on the Hollywood Walk of Fame (at 6922 Hollywood Boulevard). Max Factor is ...

https://en.wikipedia.org/wiki/Max_Factor,_Sr.

JavaScript is disabled for your browser. Some features of this site may not work without it ...

https://apps.who.int/iris/handle/10665/89612/browse?authority=Socioeconomic+Factors&type=mesh

Learn for free about math, art, computer programming, economics, physics, chemistry, biology, medicine, finance, history, and more. Khan Academy is a nonprofit with the mission of providing a free, world-class education for anyone, anywhere.

https://www.khanacademy.org/math/college-algebra/xa5dd2923c88e7aa8:polynomial-arithmetic/xa5dd2923c88e7aa8:factoring-using-structure/e/factoring_difference_of_squares_3

... The Behavioral Risk Factor Surveillance System (BRFSS) data for health assessment ...

https://wonder.cdc.gov/brfss.html

The lagoon water level being at its seasonal highest this time of year, as the Gulf Stream slows, pushing more ocean into inlets, and as the world warms.

https://www.floridatoday.com/story/news/local/environment/lagoon/2019/11/15/climate-change-one-factor-rising-indian-river-lagoon-level/4191406002/

They can be caused by several factors, including the weather, licking your lips too much, and even taking certain medications. ... Keloids and hypertrophic scars are similar in many ways but differ in their risk factors, treatment, and outlook. ...

https://www.healthline.com/health/chapped-lips

Smoothcreations Small Form Factor Lan Shark PC ...

https://www.tweaktown.com/pressrelease/352/smoothcreations_small_form_factor_lan_shark_pc/index.html

... fear factor and could be heading towards a West Indies-style decline, batting great Brian Lara has warned. ... "The fear factor is no longer there and a similar thing happened to the West Indies 25 years ago," Lara told News Corp ... Australias cricketers have lost their "fear factor" and could be heading towards a West Indies-style decline, batting great ...

https://www.thedailystar.net/sports/cricket/aus-have-lost-fear-factor-says-lara-1315564

Yubico.com is your source for top-rated secure two-factor authentication security keys and HSMs. Purchase the YubiKey security ...

https://www.yubico.com/bf/store/compare/security-key-nfc-by-yubico,security-key-c-nfc-by-yubico/

Here are some factors that may affect Middle East stock markets on Wednesday. ... DUBAI - Here are some factors that may affect Middle East stock markets on Wednesday. Reuters has not verified the press ... Here are some factors that may affect Middle East stock markets on Wednesday. ...

https://www.zawya.com/en/markets/mideast-stocks-factors-to-watch-on-july-18-wxl6s572

What are some of the success factors these programs identify?. Consistency. "Consistency is so important! If youre not ...

https://www.bai.org/banking-strategies/success-factors-for-fixing-the-bank/

I call this establishing the T.R.U.S.T. factor.. The following five strategies will help you form strong relationships and long ... The Trust Factor Win your customers faith by learning the 5 key components of trust. ... Ask any top sales performer what factors contribute to their success, and youll hear that building trust is vital in their ...

https://www.entrepreneur.com/growing-a-business/sales-techniques-the-trust-factor/174726

X-Factor: Wahre Lügen[Bearbeiten , Quelltext bearbeiten]. X-Factor: Wahre Lügen war eine deutsche Sendung, die sich an X-Factor ... X-Factor: Das Unfassbare bei Fernsehserien.de. Einzelnachweise[Bearbeiten , Quelltext bearbeiten]. *↑ X-Factor bei ... X-Factor: Die fünfte Dimension[Bearbeiten , Quelltext bearbeiten]. In X-Factor: Die fünfte Dimension (auch nach dem Logo X- ... X-Factor: Die wahre Dimension der Angst[Bearbeiten , Quelltext bearbeiten]. X-Factor: Die wahre Dimension der Angst ( ...

https://de.wikipedia.org/wiki/X-Factor:_Das_Unfassbare

Diagnosis and treatment of inherited factor X deficiency. (medlineplus.gov)
Inherited factor X deficiency is autosomal recessive, with heterozygotes most often remaining asymptomatic or having only a mild bleeding tendency. (medscape.com)

A novel homozygous mutation (Gly1715Ser) causing hereditary factor V deficiency in a Chinese patient. (medscape.com)

The inherited form of factor X deficiency, known as congenital factor X deficiency, is caused by mutations in the F10 gene, which provides instructions for making a protein called coagulation factor X. This protein plays a critical role in the coagulation system, which is a series of chemical reactions that forms blood clots in response to injury. (medlineplus.gov)
A non-inherited form of the disorder, called acquired factor X deficiency, is more common than the congenital form. (medlineplus.gov)
Girolami A, Scarparo P, Scandellari R, Allemand E. Congenital factor X deficiencies with a defect only or predominantly in the extrinsic or in the intrinsic system: a critical evaluation. (medlineplus.gov)
Girolami A, Vettore S, Scarparo P, Lombardi AM. Persistent validity of a classification of congenital factor X defects based on clotting, chromogenic and immunological assays even in the molecular biology era. (medlineplus.gov)
Karimi M, Menegatti M, Afrasiabi A, Sarikhani S, Peyvandi F. Phenotype and genotype report on homozygous and heterozygous patients with congenital factor X deficiency. (medlineplus.gov)
Mitterstieler G, Muller W, Geir W. Congenital factor V deficiency. (medscape.com)
Shirzadi M, Radfar AH, Dehghani M. Recurrent miscarriage in a woman with congenital factor V deficiency: a case report. (medscape.com)
Gastrointestinal bleeding in a newborn infant with congenital factor X deficiency and COVID-19 may represent a clinical feature that the two diseases have in common. (medscape.com)
G factor X gene mutations are responsible for congenital factor X deficiency in patients of Nepali and Indian origin. (medscape.com)
[ 2 ] Pedigree analysis of patients with congenital factor X deficiency often reveals consanguinity. (medscape.com)

Multi-Factor Authentication (MFA) is a critical cybersecurity tool used to confirm your identity and helps prevent hackers from gaining access to your personal information and NYU's network. (nyu.edu)
The TeamViewer Management Console manages the two-factor authentication. (teamviewer.com)
Two-factor authentication , then click Activate . (teamviewer.com)
See also Recovery Code for Two-Factor Authentication . (teamviewer.com)
This video shows you step by step how to activate the two-factor authentication for your TeamViewer Account. (teamviewer.com)
There are two possible ways to deactivate two-factor authentication. (teamviewer.com)
You need your TeamViewer Account credentials and your recovery code to deactivate the two-factor authentication. (teamviewer.com)
How Has Mobile Changed Multi-factor Authentication? (cio.com)
Multi-factor Authentication (MFA) has always been a challenge for end users. (cio.com)
BoilerKey, Purdue's version of two-factor authentication, improves the security of protected computer systems and personal data. (purdue.edu)
What is Two-Factor Authentication? (purdue.edu)
Two-factor authentication (also known as multi-factor authentication or two-step verification) is an extra layer of protection - more protection than a traditional password. (purdue.edu)
Two-factor authentication should be used on accounts that contain sensitive information, such as bank accounts, Social Security numbers, health information, and more. (purdue.edu)
Provide Kerberos enabled, LDAP replicated, two-factor authentication for FreeIPA. (fedoraproject.org)
Until recently, no two-factor authentication was possible with Kerberos. (fedoraproject.org)
However, the standardization of RFC 6560 combined with recent work in the MIT krb5 code makes it possible to now offer support for two-factor authentication in Kerberos. (fedoraproject.org)
Users of FreeIPA will be able to deploy two-factor authentication across the replicated user directory. (fedoraproject.org)
When an admin configures a user for two-factor authentication, the authenticating user will need to use a TOTP client. (fedoraproject.org)
Two Factor Authentication is now available for FreeIPA. (fedoraproject.org)
Google announced it will force users to use two-factor authentication to sign in earlier this year, and the tech giant is honoring its word by auto-enrolling people to use its 2-Step Verification (2SV) process. (laptopmag.com)
Google's goal is to automatically enroll 150 million user accounts to start using its two-factor authentication security process by the end of 2021, which requires people to sign in using a password and confirm their identity on another device via a "Google Prompt" - commonly done on a smartphone. (laptopmag.com)
Multi-factor authentication (MFA) is a digital authentication method used to confirm the identity of a user to allow them access to a website or app through at least two pieces of evidence. (laptopmag.com)
Two-factor authentication (2FA), which Google calls 2VS, is the most commonly used method. (laptopmag.com)
As you'll find in our PSA about two-factor authentication , malicious hackers can easily use 2FA against users that use their phone numbers. (laptopmag.com)
For the best way to use two-factor authentication, check out our guide on how to do 2FA right . (laptopmag.com)
Whether it's connecting Scar from The Lion King to two-factor authentication or turning his love for gadgets into a fabricated rap battle from 8 Mile, he believes there's always a quirky spin to be made. (laptopmag.com)

Im Herbst 2021 wurde bekannt, dass es neue Geschichten von X-Factor: Das Unfassbare geben wird. (wikipedia.org)

Australia's cricketers have lost their "fear factor" and could be heading towards a West Indies-style decline, batting great Brian Lara has warned. (thedailystar.net)
The fear factor is no longer there and a similar thing happened to the West Indies 25 years ago," Lara told News Corp newspapers. (thedailystar.net)

2019. Rheumatoid Factor Test . (news-medical.net)

The X Factor Final 2018: Who won? (wikipedia.org)

Zheng C, Zhang B. Combined deficiency of coagulation factors V and VIII: an update. (medscape.com)
Alsheikh S, Alghamdi R, Alqatari A, Alfareed A, AlSaleh M. Combined Factor V and VIII Deficiency with LMAN1 Mutation: A Report of 3 Saudi Siblings. (medscape.com)
It also functions in a positive feedback loop by activating factor V , factor VII , and factor VIII . (medscape.com)
Factor Xa can suppress the coagulation cascade by inactivating both factor VIII and tissue factor. (medscape.com)

Reduced quantity or function of coagulation factor X prevents blood from clotting normally, causing episodes of abnormal bleeding that can be severe. (medlineplus.gov)
The anticoagulant function of coagulation factor V. Thromb Haemost . (medscape.com)

If you have factor V Leiden and have developed blood clots, anticoagulant medications can lessen your risk of developing additional blood clots and help you avoid potentially serious complications. (mayoclinic.org)
Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot. (mayoclinic.org)
A family history of factor V Leiden increases your risk of inheriting the disorder. (mayoclinic.org)
Women with factor X deficiency can have heavy or prolonged menstrual bleeding (menorrhagia) or excessive bleeding in childbirth, and may be at increased risk of pregnancy loss (miscarriage). (medlineplus.gov)
Factor V Leiden and Ischemic Stroke Risk: The Genetics of Early Onset Stroke (GEOS) Study. (medscape.com)
A number of assessment tools are readily available to identify adults' fall risk factors. (mnfallsprevention.org)
The MFS requires systematic, reliable assessment of a client's fall risk factors upon admission, after a fall, with a change in status, and at discharge or transfer to a new setting. (mnfallsprevention.org)
Environmental factors that cause vascular injury (e.g., surgery), stasis (e.g., prolonged immobility), or increased coagulability (e.g., hormone use) interact with genetic susceptibility to increase the risk for thrombosis. (cdc.gov)
Increased risk of venous thrombosis in OC users who are carriers of factor V Leiden mutation. (cdc.gov)
Lifestyle related risk factors such as tobacco use, harmful use of alcohol, unhealthy diet, and insufficient physical activity are known modifiable contributors to non-communicable diseases (NCDs) and mental health issues2. (who.int)
Preventing these risk factors will have a dual beneficial effect of reducing the number of people at risk of severe disease as well as improving the recovery of those affected by COVID-19. (who.int)
It is a major risk factor for non-communicable diseases (NCDs) including cardiovascular disease, chronic respiratory disease, diabetes and cancer4. (who.int)
For example, cigarette smoking is a risk factor for lung cancer , and obesity is a risk factor for heart disease . (rxlist.com)
Family health history is a non-modifiable risk factor-or is it? (cdc.gov)
ABSTRACT Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant (FVIIc) levels that have been associated with cardiovascular risk. (who.int)
Here you'll find in-depth information on specific cancer types - including risk factors, early detection, diagnosis, and treatment options. (cancer.org)
A risk factor is anything that affects your chance of getting a disease such as cancer. (cancer.org)
Different cancers have different risk factors. (cancer.org)
Some risk factors, like smoking, can be changed. (cancer.org)
But having a risk factor, or even many risk factors, doesn't mean that a person will get the disease. (cancer.org)
And many people who get the disease may have few or no known risk factors. (cancer.org)
Scientists have found some risk factors that make a person more likely to develop gallbladder cancer. (cancer.org)
Gallstones are the most common risk factor for gallbladder cancer. (cancer.org)
Gallstones and gallbladder inflammation are important risk factors for gallbladder cancer and are also much more common in women than men. (cancer.org)
Obesity is also a risk factor for gallstones, which might help explain this link. (cancer.org)
This handout helps outline the most common risk factors associated with HIV/AIDS, as well as best practices for risk reduction. (nnedv.org)
When examining chronic diseases and their potential connection to the environment, it is important to consider lifestyle risk factors that could play a role in their development. (cdc.gov)
Lifestyle risk factor data on the Tracking Network can be used by public health professionals to determine if certain health outcomes are related to the environment or if they could also be due to lifestyle risk factors such as smoking and lack of physical activity. (cdc.gov)
The data can also be used by public health officials to determine the best public health actions to reduce modifiable lifestyle risk factors in their communities. (cdc.gov)
The Tracking Network hosts the following lifestyle risk factor data. (cdc.gov)
Data sources include CDC's Behavioral Risk Factor Surveillance System , CDC's Population Level Analysis and Community Estimates (PLACES) Project, and the U.S. Census Bureau external icon . (cdc.gov)
Read these success stories to learn about lifestyle risk factors related work happening in our funded Tracking Programs. (cdc.gov)
The Expanded Risk Factor Surveillance System (Expanded BRFSS) augments the CDC Behavioral Risk Factor Surveillance System (BRFSS) , which is conducted annually in New York State. (ny.gov)
Select one of those statistics in the Screening and Risk Factors drop-down, and then you can choose County-Level Modeled Estimates in the Data Type drop-down when you choose Counties for a specific state (e.g. (cancer.gov)
Data on health risk factors and conditions were collected in National Health Interview Surveys from household interviews with samples of the civilian, noninstitutionalized population. (cdc.gov)
A growing body of research shows that ESG factors are a material credit risk for fixed income investors. (worldbank.org)
Wu, Y.W. and Colford, J.M. Jr (2000) Chorioamnionitis as a risk factor for cerebral palsy, a meta-analysis. (scirp.org)
Maternal and foetal risk factors of cerebral palsy among Iraqi children. (scirp.org)
In Iraq, risk factors of cerebral palsy have not been explored before. (scirp.org)
Postnatal risk factors of cerebral palsy were excluded in our study. (scirp.org)
Cases and controls were fully investtigated (retrospectively) for the risk factors of cerebral palsy using a self-administered questionnaire. (scirp.org)
Our study came to a conclusion that neonatal asphyxia, hypoglycemia and hypocalcaemia were still the major risk factors for cerebral palsy In Iraq. (scirp.org)
In general, the term "factor" is used to describe any characteristic that can help explain the risk and return performance of an asset. (msci.com)
This measure enabled independent investigation of potential risk factors for infection, such as frequency of classroom ventilation and classroom space, for each of the case-patients and controls. (cdc.gov)
was collected on potential risk factors related to personal hygiene habits, vaccination history, and means of transportation. (cdc.gov)
Questions cover behavioral risk factors (e.g., alcohol and tobacco use), preventive health measures, health status, limitation of activity, and health care access and utilization. (cdc.gov)
The repository of legislation on risk factors offers Member States organized, systematized, and updated legal information on the main risk factors for noncommunicable diseases (NCDs). (bvsalud.org)
International recommendations based on solid scientific evidence point to regulatory measures as one of the most effective ways to address NCD risk factors. (bvsalud.org)
Knowing risk factors and resilience factors can help reduce risk, according to the National Institute of Mental Health. (medlineplus.gov)

Factor X deficiency is a rare bleeding disorder that varies in severity among affected individuals. (medlineplus.gov)

Delev D, Pavlova A, Heinz S, Seifried E, Oldenburg J. Factor 5 mutation profile in German patients with homozygous and heterozygous factor V deficiency. (medscape.com)

Under normal conditions, procoagulant and anticoagulant factors in the blood are in balance. (cdc.gov)
Acquired factor X deficiency can be caused by severe liver disease, vitamin K deficiency , or anticoagulant drugs such as warfarin. (medscape.com)

Retrieved on December 10, 2022 from https://www.news-medical.net/health/Rheumatoid-Factor-Test.aspx. (news-medical.net)

Some F10 gene mutations that cause factor X deficiency reduce the amount of coagulation factor X in the bloodstream, resulting in a form of the disorder called type I. Other F10 gene mutations result in the production of a coagulation factor X protein with impaired function, leading to type II factor X deficiency. (medlineplus.gov)
Familial coagulation factor V deficiency caused by a novel 4 base pair insertion in the factor V gene: factor V Stanford. (medscape.com)
Profiling the mutational landscape of coagulation factor V deficiency. (medscape.com)
Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice. (medscape.com)
Inhibitors of coagulation factor Xa (fXa) have emerged as a new class of antithrombotics but lack effective antidotes for patients experiencing serious bleeding. (nih.gov)
Hemophilia B, or Christmas disease, is an inherited, recessive disorder that involves deficiency of functional coagulation factor IX (FIX) in plasma. (medscape.com)
Coagulation factor tests are blood tests that check one or more of your clotting factors to see if. (medlineplus.gov)

Autoimmune acquired factor XIII (FXIII) deficiency is a rare disorder characterized by severe spontaneous hematomas and autoantibodies against FXIII. (bvsalud.org)

Topics assessed by the Expanded BRFSS include tobacco use, physical inactivity, diet, use of cancer screening services, and other factors linked to the leading causes of morbidity and mortality. (ny.gov)

Our study objective was to measure the association between, maternal factors, foetal and early neonatal factors, and occurrence of cerebral palsy among Iraqi children. (scirp.org)

With struggling ratings in the standard X Factor series, Simon Cowell announced that he was going to shake things up this year by doing a celebrity spin-off of the ITV contest and we're not going to lie, this line-up will definitely have us tuning in. (yahoo.com)
Simon Cowell has announced his return to the U.K. X Factor show - a move precluding him from coming back to The X Factor U.S. - and seeing the writing on the wall, Fox has canceled the entire show. (sheknows.com)
Unfortunately, there is no X Factor USA without Simon Cowell, but we understand and support his decision to focus on the international formats and on the next phase of his personal life. (sheknows.com)

This disorder is one of the world's most rare factor deficiencies. (medscape.com)

Note that any integer content (see first example below) is not factored. (maplesoft.com)
In diabetics,high urine glucose content and defective host immune factors predispose to infection. (medscape.com)

Autoimmune Acquired Factor XIII Deficiency: A Case Report. (bvsalud.org)

Genetic analysis of hereditary factor X deficiency in a French patient of Sri Lankan ancestry: in vitro expression study identified Gly366Ser substitution as the molecular basis of the dysfunctional factor X. Blood Coagul Fibrinolysis . (medscape.com)

Genetic factors levels vary significantly in the general pop- contribute significantly to the development ulation and are influenced by environmental of these diseases. (who.int)

Acquired factor X deficiency can be caused by other disorders such as severe liver disease or systemic amyloidosis, a condition involving the accumulation of abnormal proteins called amyloids. (medlineplus.gov)
Utility of factor X concentrate for the treatment of acquired factor X deficiency in systemic light-chain amyloidosis. (medscape.com)
Systemic factors stem from the unique health care cultural environment, which is marked by pressures that include increased productivity demands, cost containment requirements, embedded hierarchies, and fear of or stress from litigation. (cdc.gov)

In vitro" correction of the severe factor V deficiency-related coagulopathy by a novel plasma-derived factor V concentrate. (medscape.com)
Kulkarni R, James AH, Norton M, Shapiro A. Efficacy, safety and pharmacokinetics of a new high-purity factor X concentrate in women and girls with hereditary factor X deficiency. (medscape.com)
Treatment options include factor X concentrate, fresh frozen plasma, and prothrombin complex concentrates (PCCs). (medscape.com)

Girolami A, Scandellari R, Lombardi AM, Girolami B, Bortoletto E, Zanon E. Pregnancy and oral contraceptives in factor V deficiency: a study of 22 patients (five homozygotes and 17 heterozygotes) and review of the literature. (medscape.com)
Most patients with rheumatoid arthritis, and almost all patients with Sjogren syndrome, have positive rheumatoid factor test results. (news-medical.net)
We've invested more than $5 billion in cancer research since 1946, all to find more - and better - treatments, uncover factors that may cause cancer, and improve cancer patients' quality of life. (cancer.org)
Additionally, in patients with acquired factor X deficiency, treatment of the underlying cause may resolve the disorder. (medscape.com)
11 A factor in patients' perceptions of clinicians' responsiveness may be their ability to make patients feel respected and understood regardless of cultural differences between them. (uspharmacist.com)
We investigated the relationship of VEGF as an angiogenic growth factor and endostatin as an angiogenic inhibitor in patients with pre-eclampsia. (who.int)
Alloantibodies may arise in patients with deficiency who receive factor replacement or in patients who have received transfusions with blood products. (medscape.com)
Older patients who received unpurified plasma‐derived clotting factor concentrates may have signs and symptoms of infectious disease (eg, hepatitis, HIV infection). (medscape.com)

Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. (mayoclinic.org)
Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen. (mayoclinic.org)
The factor V Leiden mutation does not itself cause any symptoms. (mayoclinic.org)
Asp68His mutation in the A1 domain of human factor V causes impaired secretion and ineffective translocation. (medscape.com)
One missense mutation in the factor X gene causing factor X deficiency--factor X Kanazawa. (medscape.com)
A case of factor X (FX) deficiency due to novel mutation V196M, FX Hofu. (medscape.com)
In most cases, it results from a point mutation in the factor V gene, G1691A, which slows the inactivation of factor V and thus favors conversion of prothrombin to thrombin. (cdc.gov)

The In-Depth Toxicological Effects Analysis section expands on how you should weigh these factors in your evaluation of site exposures and determining public health implications. (cdc.gov)
Factor exposures are calculated 12 months prior to the total-return period. (msci.com)

Once formed, factor Xa is then responsible for the conversion of prothrombin to its active form, thrombin, which is responsible for activating fibrinogen and allowing clot formation. (medscape.com)

Acquired factor X deficiency is not inherited, and generally occurs in individuals with no history of the disorder in their family. (medlineplus.gov)
Factor X deficiency is a bleeding disorder that can be inherited or acquired. (medscape.com)

Girolami A, Cosi E, Santarossa C, Ferrari S, Girolami B, Lombardi AM. Prevalence of bleeding manifestations in 128 heterozygotes for Factor X deficiency, mainly for FX Friuli, matched vs 128 unaffected family members, during a long sequential observation period (23.5 years). (medscape.com)

Activation by the extrinsic pathway occurs via the complex of tissue factor and factor VIIa. (medscape.com)
Activated prothrombin complex (aPCC) 50-100 μg kg −1 or recombinant factor VIIa (rFVIIa) 270 μg kg −1 as a single dose (or 90 μg kg −1 2-3 hourly) are equally acceptable treatments for joint or soft tissue bleeds, with repeated doses as necessary. (medscape.com)

Acquired factor X deficiency can also be caused by certain drugs such as medicines that prevent clotting, or by a deficiency of vitamin K. (medlineplus.gov)
Owren P. Parahaemophilia: haemorrhagic diathesis due to absence of a previously unknown clotting factor. (medscape.com)
Clotting factors VII and X as useful markers of terminal deletion of chromosome 13. (medscape.com)
Clotting factor X, or Stuart-Prower factor, is a vitamin K-dependent serine protease that serves as the first enzyme in the common pathway of thrombus formation. (medscape.com)
Based on these common clotting test results, the factor was designated Stuart-Prower factor. (medscape.com)
As the first step in the common pathway to thrombus formation, factor X can be activated by products of both the intrinsic and extrinsic clotting cascades. (medscape.com)
These proteins are also called clotting factors. (medlineplus.gov)
You have several different types of clotting factors that are all important for making blood clots. (medlineplus.gov)

Therefore, pharmacists and other clinicians must continue to strive for effective communication with sensitivity toward cultural, socioeconomic, and sociodemographic factors. (uspharmacist.com)
Sociodemographic factors, socioeconomic status, and type of insurance coverage have a substantial impact on the elderly population's access to health care. (uspharmacist.com)
This entry was posted in Equity , Social determinants , Universal health coverage and tagged Argentina , Demographic , Medicine National Politics , Socioeconomic factors by Editor Equity/Equidad - DB . (bvsalud.org)

AMD's DTX small form factor specification has progressed since the announcement in January 2007. (madshrimps.be)

Most people with factor V Leiden never develop abnormal clots. (mayoclinic.org)
Both men and women can have factor V Leiden. (mayoclinic.org)
If you have factor V Leiden, you inherited either one copy or, rarely, two copies of the defective gene. (mayoclinic.org)
People who have inherited factor V Leiden from only one parent have a 5 percent chance of developing an abnormal blood clot by age 65. (mayoclinic.org)
Factor V Leiden can cause blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). (mayoclinic.org)
https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. (mayoclinic.org)
Factor V Leiden and activated protein C resistance. (mayoclinic.org)
discuss possible implications of the findings for researchers, people with Venous Thrombosis, and people with one or more of the newly described Factor V Leiden variants. (cdc.gov)

Limiting factors are environmental influences that constrain the productivity of organisms, populations, or communities and thereby prevent them from achieving their full biological potential, which could be realized under optimal conditions. (encyclopedia.com)
The functioning of an organism is controlled or limited by that essential environmental factor or combination of factors present in the least favorable amount. (encyclopedia.com)
Environmental factors must satisfy minimum and maximum criteria for life. (encyclopedia.com)
The minimal criteria for metabolically essential environmental factors represent the least availability that will sustain organisms or ecological processes, while the maxima represent toxicity or other biological damages. (encyclopedia.com)
The minimum and maximum levels of environmental factors bound a relatively broad range within which there are optimal levels at which factors exert no constraints on biological productivity. (encyclopedia.com)
The potential limitations by particular environmental factors are best studied by doing experiments, preferably in the field. (encyclopedia.com)
Limitations by toxic environmental factors can sometimes be studied by transplanting organisms into cleaner environments, for example, away from a place that is polluted by sulfur dioxide . (encyclopedia.com)
If these sorts of experiments are properly designed and the organisms do not respond to manipulation of a particular environmental characteristic, then it was not the limiting environmental factor. (encyclopedia.com)
Scientists from the International Agency for Research on Cancer (IARC) participated in a study of environmental factors and declining human fertility led by researchers from the Department of Growth and Reproduction at Copenhagen University Hospital in Denmark. (who.int)

Upon contact with tissue ferences in FVII activity levels and in geno- factor exposed by vascular injury, FVII is type frequencies depend on the ethnic cleaved to its two-chain active form, which groups [ 15 ]. (who.int)

If the rheumatoid factor is present in the patient's blood it attaches to the IgG coating the latex particles causing clumps. (news-medical.net)

Gene mutations and three-dimensional structural analysis in 13 families with severe factor X deficiency. (medscape.com)

Kidney disorders, endocarditis, cancers of blood such as leukaemia and multiple myelomas, lung and liver diseases also cause raise Rheumatoid Factor levels. (news-medical.net)

Acquired factor V deficiency in a patient with a urinary tract infection presenting with haematuria followed by multiple haemorrhages with an extremely low level of factor V inhibitor: a case report and review of the literature. (medscape.com)

In this article, therefore, we will present the principal models that discuss psychosocial factors and occupational stress: job-demand-control, job demand control support model, effort-reward imbalance model, ecological model and the National Institute for Occupational and Health (NIOSH) proposal. (bvsalud.org)

OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity. (nih.gov)

FEDERAL RESERVE statistical release H.4.1 Factors Affecting Reserve Balances of Depository Institutions and Condition Statement of Federal Reserve Banks November 2, 2017 1. (federalreserve.gov)
The GPIF are leading on sustainable investment in Japan, having introduced ESG factors into their equity portfolio in 2017. (worldbank.org)

Van den Berg SA, Verwer PE, Idema RN, Van Guldener C. Transient cefuroxime/metronidazole treatment induced factor V antibodies. (medscape.com)

10976 in exon 8 in the catalytic region of ing factors that may increase cardiovascu- the FVII gene and an insertion of a decanu- lar disease. (who.int)
We studied FVII gene poly- then activates factors IX and X leading to morphisms in healthy Tunisians with the the generation of thrombin [ 2 ]. (who.int)

CHARLOTTE, NC-Sources at Cobalt Media confirmed Tuesday that the wow factor-an intangible set of viscerally pleasing features that instill onlookers with a feeling of exhilaration and intense interest-was successfully added to this Thursday's upcoming PowerPoint presentation, entitled 'New Ideas For Integrating Social Media Into Product Marketing. (theonion.com)
Now that they've added the final touches of wow factor to Thursday's presentation, employees seem confident their pitch is a can't-miss. (theonion.com)
The X-Factor" last Wednesday had 4.5 million viewers, with Thursday's audience 3.7 million. (billboard.com)

As a founder of the cosmetics giant Max Factor & Company , he largely developed the modern cosmetics industry in the United States and popularized the term " make-up " in noun form based on the verb. (wikipedia.org)
This provides a fully-factored form which can be used to simplify an expression in the same way the normal function is used. (maplesoft.com)
AMD's DTX Form Factor: Smaller PCs for Everyone? (madshrimps.be)
In the blood coagulation cascade, factor X is cleaved to form factor Xa, an active serine protease. (medscape.com)

This is a graphical representation af the present factors at the Workplace possible to result in hazard to health. (bvsalud.org)

Anatomy1

Organisms3

Diseases3

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes8

Information Science2

Evidence suggesting the regulation of a coagulation factor levels in rabbits by a transferable plasma agent. (1/674)

Plasmin converts factor X from coagulation zymogen to fibrinolysis cofactor. (2/674)

Coagulation factors II, V, VII, and X, prothrombin gene 20210G-->A transition, and factor V Leiden in coronary artery disease: high factor V clotting activity is an independent risk factor for myocardial infarction. (3/674)

Domain identification of hormone-sensitive lipase by circular dichroism and fluorescence spectroscopy, limited proteolysis, and mass spectrometry. (4/674)

The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity. (5/674)

Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage. (6/674)

Dietary lipid lowering reduces tissue factor expression in rabbit atheroma. (7/674)

"Normal" thrombin generation. (8/674)

Factor X

Factor Xa

Factor IXa

Factor IX

Factor VIIa

Hypoprothrombinemias

Thromboplastin

Prothrombin

Factor VIIIa

Factor VII

Blood Coagulation

1-Carboxyglutamic Acid

Factor VIII

Blood Coagulation Factors

Vitamin K

Blood Coagulation Tests

Thrombin

Snake Venoms

Dysprosium

Coagulants

Viper Venoms

Kinetics

Factor Va

Antithrombin III

Cattle

Phospholipids

Partial Thromboplastin Time

Factor V

Ytterbium

Prothrombin Time

Amino Acid Sequence

Phosphatidylserines

Factor VII Deficiency

X Chromosome

Warfarin

Carbon-Carbon Ligases

Peptide Fragments

Molecular Sequence Data

Antithrombins

Binding Sites

Blood Coagulation Disorders

Protein Binding

Electrophoresis, Polyacrylamide Gel

Samarium

Protein S

Protein C

Factor XIa

Benzamidines

Viperidae

Snakes

Recombinant Proteins

Anticoagulants

Evidence suggesting the regulation of a coagulation factor levels in rabbits by a transferable plasma agent. (1/674)

Plasmin converts factor X from coagulation zymogen to fibrinolysis cofactor. (2/674)

Coagulation factors II, V, VII, and X, prothrombin gene 20210G-->A transition, and factor V Leiden in coronary artery disease: high factor V clotting activity is an independent risk factor for myocardial infarction. (3/674)

Domain identification of hormone-sensitive lipase by circular dichroism and fluorescence spectroscopy, limited proteolysis, and mass spectrometry. (4/674)

The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity. (5/674)

Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage. (6/674)

Dietary lipid lowering reduces tissue factor expression in rabbit atheroma. (7/674)

"Normal" thrombin generation. (8/674)

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