Factor x. Medical search

Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.

Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.

Activated form of factor IX. This activation can take place via the intrinsic pathway by the action of factor XIa and calcium, or via the extrinsic pathway by the action of factor VIIa, thromboplastin, and calcium. Factor IXa serves to activate factor X to Xa by cleaving the arginyl-leucine peptide bond in factor X.

Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).

Activated form of factor VII. Factor VIIa activates factor X in the extrinsic pathway of blood coagulation.

Absence or reduced levels of PROTHROMBIN in the blood.

Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.

A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.

Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.

Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. The activated form then catalyzes the activation of factor X to factor Xa.

The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.

Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.

Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.

Endogenous substances, usually proteins, that are involved in the blood coagulation process.

A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.

Laboratory tests for evaluating the individual's clotting mechanism.

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.

Solutions or mixtures of toxic and nontoxic substances elaborated by snake (Ophidia) salivary glands for the purpose of killing prey or disabling predators and delivered by grooved or hollow fangs. They usually contain enzymes, toxins, and other factors.

Dysprosium. An element of the rare earth family that has the atomic symbol Dy, atomic number 66, and atomic weight 162.50. Dysprosium is a silvery metal used primarily in the form of various salts.

Agents that cause clotting.

Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.

The rate dynamics in chemical or physical systems.

Activated form of factor V. It is an essential cofactor for the activation of prothrombin catalyzed by factor Xa.

A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.

The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.

Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.

Ytterbium. An element of the rare earth family of metals. It has the atomic symbol Yb, atomic number 70, and atomic weight 173. Ytterbium has been used in lasers and as a portable x-ray source.

Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.

An autosomal recessive characteristic or a coagulation disorder acquired in association with VITAMIN K DEFICIENCY. FACTOR VII is a Vitamin K dependent glycoprotein essential to the extrinsic pathway of coagulation.

The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in human and other male-heterogametic species.

An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

Samarium. An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.

The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.

A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.

Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa in the presence of cofactor HMWK; (HIGH MOLECULAR WEIGHT KININOGEN). Factor XIa then activates factor IX to factor IXa in the presence of calcium.

Amidines substituted with a benzene group. Benzamidine and its derivatives are known as peptidase inhibitors.

A family of snakes comprising three subfamilies: Azemiopinae (the mountain viper, the sole member of this subfamily), Viperinae (true vipers), and Crotalinae (pit vipers). They are widespread throughout the world, being found in the United States, Central and South America, Europe, Asia and Africa. Their venoms act on the blood (hemotoxic) as compared to the venom of elapids which act on the nervous system (neurotoxic). (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, pp333-36)

Limbless REPTILES of the suborder Serpentes.

Proteins prepared by recombinant DNA technology.

Agents that prevent clotting.

Evidence suggesting the regulation of a coagulation factor levels in rabbits by a transferable plasma agent. (1/674)

New Zealand white rabbits were given 30 ml of goat serum intravenously. This procedure resulted in an immediate decrease in platelet count, fibrinogen, and levels of coagulation factors II, V, VII, and X, due to consumption coagulopathy. These factors returned toward baseline levels approximately 12 hr after the injection. Plasma from rabbits who had received goat serum 48 hr previously (donor rabbits) was injected into recipient rabbits. This procedure resulted in a slight rise in the level of coagulation factor II (range, 20%-30%) and a significant rise in factors V (35%-75%), VII (35%-235%), and X (35%-75%) in the recipients. When plasma from control donor rabbits who had not received goat serum was injected into recipients, there was no change in these coagulation factors. It is postulated that the reduction in coagulation factor levels in donor rabbits induces a "coagulopoietin" for each factor or one "coagulopoietin" for all factors which stimulates increased synthesis and/or release of these factors in recipient rabbits. (+info)

Plasmin converts factor X from coagulation zymogen to fibrinolysis cofactor. (2/674)

Known anticoagulant pathways have been shown to exclusively inhibit blood coagulation cofactors and enzymes. In the current work, we first investigated the possibility of a novel anticoagulant mechanism that functions at the level of zymogen inactivation. Utilizing both clotting and chromogenic assays, the fibrinolysis protease plasmin was found to irreversibly inhibit the pivotal function of factor X (FX) in coagulation. This was due to cleavage at several sites, the location of which were altered by association of FX with procoagulant phospholipid (proPL). The final products were approximately 28 and approximately 47 kDa for proPL-bound and unbound FX, respectively, which did not have analogues when activated FX (FXa) was cleaved instead. We next investigated whether the FX derivatives could interact with the plasmin precursor plasminogen, and we found that plasmin exposed a binding site only on proPL-bound FX. The highest apparent affinity was for the 28-kDa fragment, which was identified as the light subunit disulfide linked to a small fragment of the heavy subunit (Met-296 to approximately Lys-330). After cleavage by plasmin, proPL-bound FX furthermore was observed to accelerate plasmin generation by tissue plasminogen activator. Thus, a feedback mechanism localized by proPL is suggested in which plasmin simultaneously inhibits FX clotting function and converts proPL-bound FX into a fibrinolysis cofactor. These data also provide the first evidence for an anticoagulant mechanism aimed directly at the zymogen FX. (+info)

Coagulation factors II, V, VII, and X, prothrombin gene 20210G-->A transition, and factor V Leiden in coronary artery disease: high factor V clotting activity is an independent risk factor for myocardial infarction. (3/674)

Increased levels of hemostatic factors and genetic mutations of proteins involved in coagulation may play a role in the pathogenesis of coronary artery disease. We investigated clotting activity of factors II (FII:C), V (FV:C), VII (FVII:C), and X (FX:C), the prothrombin gene 20210G-->A transition, and the factor V Leiden mutation in 200 survivors of myocardial infarction and in 100 healthy controls. FV:C (P<0.0001) and FVII:C (P<0.0001) were found to be independent risk factors for myocardial infarction. High FV:C or high FVII:C combined with smoking or arterial hypertension increased the relative risk for myocardial infarction up to 50-fold. One of 177 patients (0.6%) and 4 of 89 controls (4.5%) had the prothrombin 20210 AG genotype. Eleven of 177 patients (6.2%) and 6 of 89 controls (6.7%) were heterozygous for the factor V Leiden mutation. No homozygous carrier for these mutations was found. Neither the prothrombin gene 20210G-->A transition (odds ratio [OR], 0.1; 95% confidence interval [CI], 0.01 to 1.1) nor the factor V Leiden mutation (OR, 1.0; 95% CI, 0.4 to 2.8) were associated with an increased relative risk for myocardial infarction. In conclusion, our data indicate that neither the prothrombin gene 20210G-->A transition nor the factor V Leiden mutation are risk factors for myocardial infarction. High FVII:C was confirmed to be an independent risk factor for myocardial infarction. Moreover, we describe for the first time that high FV:C is an independent risk factor for myocardial infarction. (+info)

Domain identification of hormone-sensitive lipase by circular dichroism and fluorescence spectroscopy, limited proteolysis, and mass spectrometry. (4/674)

Structure-function relationship analyses of hormone-sensitive lipase (HSL) have suggested that this metabolically important enzyme consists of several functional and at least two structural domains (Osterlund, T., Danielsson, B., Degerman, E., Contreras, J. A., Edgren, G., Davis, R. C., Schotz, M. C., and Holm, C. (1996) Biochem. J. 319, 411-420; Contreras, J. A., Karlsson, M., Osterlund, T., Laurell, H., Svensson, A., and Holm, C. (1996) J. Biol. Chem. 271, 31426-31430). To analyze the structural domain composition of HSL in more detail, we applied biophysical methods. Denaturation of HSL was followed by circular dichroism measurements and fluorescence spectroscopy, revealing that the unfolding of HSL is a two-step event. Using limited proteolysis in combination with mass spectrometry, several proteolytic fragments of HSL were identified, including one corresponding exactly to the proposed N-terminal domain. Major cleavage sites were found in the predicted hinge region between the two domains and in the regulatory module of the C-terminal, catalytic domain. Analyses of a hinge region cleavage mutant and calculations of the hydropathic pattern of HSL further suggest that the hinge region and regulatory module are exposed parts of HSL. Together, these data support our previous hypothesis that HSL consists of two major structural domains, encoded by exons 1-4 and 5-9, respectively, of which the latter contains an exposed regulatory module outside the catalytic alpha/beta-hydrolase fold core. (+info)

The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity. (5/674)

Factor VIIIa, the protein cofactor for factor IXa, is comprised of A1, A2, and A3-C1-C2 subunits. Recently, we showed that isolated A2 subunit enhanced the kcat for factor IXa-catalyzed activation of factor X by approximately 100-fold ( approximately 1 min-1), whereas isolated A1 or A3-C1-C2 subunits showed no effect on this rate (Fay, P. J., and Koshibu, K. J. (1998) J. Biol. Chem. 273, 19049-19054). However, A1 subunit increased the A2-dependent stimulation by approximately 10-fold. The Km for factor X in the presence of A2 subunit was unaffected by A1 subunit, whereas the kcat observed in the presence of saturating A1 and A2 subunits ( approximately 15 min-1) represented 5-10% of the value observed for native factor VIIIa (approximately 200 min-1). An anti-A1 subunit antibody that blocks the association of A2 eliminated the A1-dependent contribution to factor IXa activity. Inclusion of both A1 and A2 subunits resulted in greater increases in the fluorescence anisotropy of fluorescein-Phe-Phe-Arg factor IXa than that observed for A2 subunit alone and approached values obtained with factor VIIIa. These results indicate that A1 subunit alters the A2 subunit-dependent modulation of the active site of factor IXa to synergistically increase cofactor activity, yielding an overall increase in kcat of over 1000-fold compared with factor IXa alone. (+info)

Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage. (6/674)

Agents that restore vascular patency in stroke also increase the risk of intracerebral hemorrhage (ICH). As Factor IXa is a key intermediary in the intrinsic pathway of coagulation, targeted inhibition of Factor IXa-dependent coagulation might inhibit microvascular thrombosis in stroke without impairing extrinsic hemostatic mechanisms that limit ICH. A competitive inhibitor of native Factor IXa for assembly into the intrinsic Factor X activation complex, Factor IXai, was prepared by covalent modification of the Factor IXa active site. In a modified cephalin clotting time assay, in vivo administration of Factor IXai caused a dose-dependent increase in time to clot formation (3.6-fold increase at the 300 micrograms/kg dose compared with vehicle-treated control animals, P < 0.05). Mice given Factor IXai and subjected to middle cerebral artery occlusion and reperfusion demonstrated reduced microvascular fibrin accumulation by immunoblotting and immunostaining, reduced 111In-labeled platelet deposition (42% decrease, P < 0.05), increased cerebral perfusion (2.6-fold increase in ipsilateral blood flow by laser doppler, P < 0.05), and smaller cerebral infarcts than vehicle-treated controls (70% reduction, P < 0.05) based on triphenyl tetrazolium chloride staining of serial cerebral sections. At therapeutically effective doses, Factor IXai was not associated with increased ICH, as opposed to tissue plasminogen activator (tPA) or heparin, both of which significantly increased ICH. Factor IXai was cerebroprotective even when given after the onset of stroke, indicating that microvascular thrombosis continues to evolve (and may be inhibited) even after primary occlusion of a major cerebrovascular tributary. (+info)

Dietary lipid lowering reduces tissue factor expression in rabbit atheroma. (7/674)

BACKGROUND: The mechanisms by which lipid lowering reduces the incidence of acute thrombotic complications of coronary atheroma in clinical trials remains unknown. Tissue factor (TF) overexpressed in atheroma may accelerate thrombus formation at the sites of plaque disruption. A cell surface cytokine CD40 ligand (CD40L) enhances TF expression in vitro. METHODS AND RESULTS: To test the hypothesis that lipid lowering reduces TF expression and activity, we produced atheroma in rabbit aortas by balloon injury and cholesterol feeding for 4 months (Baseline group, n=15), followed by either a chow diet (Low group, n=10) or a continued high-cholesterol diet for 16 months (High group, n=5). Immunolocalization of TF, CD40L, and its receptor CD40 was quantified by computer-assisted color image analysis. Macrophages in atheroma of the Baseline and High groups strongly expressed TF. Intimal smooth muscle cells and endothelial cells also contained immunoreactive TF. Regions of expression of CD40L and CD40 colocalized with TF. Protein expression of TF diminished substantially in the Low group in association with reduced expression of CD40L and CD40. In situ binding of TF to factors VIIa and X, detected by digoxigenin-labeled factors VIIa and X, colocalized with TF protein in atheroma and decreased after lipid lowering. We also determined reduced TF biological activity in the Low group by use of a chromogenic assay. The level of TF mRNA detected by reverse transcription-polymerase chain reaction also decreased after lipid lowering. CONCLUSIONS: These results suggest decreased expression and activity of TF as a novel mechanism of reduced incidence of thrombotic complications of atherosclerosis by lipid lowering. (+info)

"Normal" thrombin generation. (8/674)

We have investigated the influence of alterations in plasma coagulation factor levels between 50% and 150% of their mean values for prothrombin, factor X, factor XI, factor IX, factor VII, factor VIII, factor V, protein C, protein S, antithrombin III (AT-III), and tissue factor pathway inhibitor (TFPI) as well as combinations of extremes, eg, 50% anticoagulants and 150% procoagulants or 50% procoagulants and 150% anticoagulants in a synthetic "plasma" system. The reaction systems were constructed in vitro using purified, natural, and recombinant proteins and synthetic phospholipid vesicles or platelets with the reactions initiated by recombinant tissue factor (TF)-factor VIIa complex (5 pmol/L). To investigate the influence of the protein C system, soluble thrombomodulin (Tm) was also added to the reaction mixture. For the most extreme situations in which the essential plasma procoagulants (prothrombin, and factors X, IX, V, and VIII) and the stoichiometric anticoagulants (AT-III and TFPI) were collectively and inversely altered by 50%, a 28-fold difference in the total available thrombin generated was observed. Variations of most of these proteins 50% above and below the "normal" range, with the remainder at 100%, had only modest influences on the peak and total levels of thrombin generated. The dominant factors influencing thrombin generation were prothrombin and AT-III. When these 2 components were held at 100% and all other plasma procoagulants were reduced to 50%, there was a 60% reduction in the available thrombin generated. No increase in the thrombin generated was observed when the 150% level of all plasma procoagulants other than prothrombin was evaluated. When only prothrombin was raised to 150%, and all other factors were maintained at 100%, the thrombin generated increased by 71% to 121%. When AT-III was at 50% and all other constituents were at 100%, thrombin production was increased by 104% to 196%. The additions of protein C and protein S over the 50% to 150% ranges with Tm at 0.1 nmol/L concentration had limited influence on thrombin generation. Individual variations in factors VII, XI, and X concentrations had little effect on the duration of the initiation phase, the peak thrombin level achieved, or the available thrombin generated. Paradoxically, increases in factor IX concentration to 150% led to lowered thrombin generation, while decreases to 50% led to enhanced thrombin generation, most likely a consequence of factor IX as a competitive substrate with factor X for factor VIIa-TF. Reductions in factor V or factor VIII concentration led to prolongations of the initiation phase, while the reduction of TFPI to 50% led to shortening of this phase. However, none of these alterations led to significant changes in the available thrombin generated. Based on these data, one might surmise that increases in prothrombin and reductions in AT-III, within the normal range, would be potential risk factors for thrombosis and that algorithms that combine normal factor levels may be required to develop predictive tests for thrombosis. (+info)

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Vaccination with irradiated granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting gene-transduced cancer vaccines ... macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and ... CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental ... Antitumor effect induced by granulocyte/macrophage-colony-stimulating factor gene-modified tumor vaccination: comparison of ...

http://cancerres.aacrjournals.org/content/59/20/5160

Migration-stimulating factor (MSF). *Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein ... Growth factors are important for regulating a variety of cellular processes. Growth factors typically act as signaling ... For example, epidermal growth factor (EGF) enhances osteogenic differentiation, [2] while fibroblast growth factors and ... "growth factor" at Dorlands Medical Dictionary *^ Del Angel-Mosqueda C, Gutiérrez-Puente Y, López-Lozano AP, Romero-Zavaleta RE ...

https://en.wikipedia.org/wiki/Growth_factor

These are called risk factors. Many risk factors can be changed or modified to help prevent falls. They include:. *Lower body ... Most falls are caused by a combination of risk factors. The more risk factors a person has, the greater their chances of ... Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly. American journal of ... Healthcare providers can help cut down a persons risk by reducing the fall risk factors listed above. ...

https://www.cdc.gov/HomeandRecreationalSafety/Falls/adultfalls.html

Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as ... Factor Xa is the activated form of the coagulation factor thrombokinase, known eponymously as Stuart-Prower factor. Factor X is ... The result is a Factor VIIa/TF complex which catalyzes the activation of Factor X and Factor IX. Factor Xa formed on the ... Factor XIa activates free Factor IX on the surface of activated platelets. The activated Factor IXa with Factor VIIIa forms the ...

https://en.wikipedia.org/wiki/Factor_X

Factor Bikes - Life After The World Tour - Duration: 2 minutes, 51 seconds.. Factor Bikes ... The Factor O2 is our beautiful chameleon - our most versatile bikes that combines minimalist beauty with exceptional ...

https://www.youtube.com/channel/UCEqdqcTAh58c9X5bYhbIaqw/feed

The money factor is an alternative method for determining the interest portion of monthly lease payments, factoring in taxes ... Calculating the Money Factor The money factor can be calculated in two ways. Firstly, money factors can be converted to ... A money factor may also be presented as a factor of 1,000, such as 2.0 rather than .002. While the decimal version is more ... What is the Money Factor The money factor is an alternative method of presenting the amount of interest charged on a lease with ...

https://www.investopedia.com/terms/m/money-factor.asp

For example, unprotected exposure to strong sunlight is a risk factor for skin cancer; smoking is a risk factor for lung, mouth ... Some risk factors have a direct role in causing cancer, but in other cases the risk may be due to something else that goes ... Some risk factors, such as smoking, can be controlled. Others, like a persons age, cant be changed. See also ,b>gene,/b>, ,b> ... along with the risk factor. For example, older age is linked to higher risk of many types of cancers, but the actual cause ...

https://www.cancer.org/cancer/glossary/glossary/r/risk_factor.html

... is strategy in which securities are chosen by attributes associated with higher returns including momentum, ... There are two main types of factors that have driven returns of stocks, bonds, and other factors; macroeconomic factors and ... What is Factor Investing Factor investing is a strategy that chooses securities on attributes that are associated with higher ... BREAKING DOWN Factor Investing Factor investing, from a theoretical standpoint, is designed to enhance diversification, ...

https://www.investopedia.com/terms/f/factor-investing.asp

Assuming Republican Norm Colemans legal challenges fail and Democrat Al Franken is seated as Minnesotas senator, can the onetime comedian, political satirist and radio talk show host make the jump to being a serious policy maker and debater? Itd be nice to think that watching Franken adjust from bawdy late night comedy and sophomoric pot shots to early morning debate on reauthorizing the Commodity Futures Trading Commission will provide some comedy relief to the anticipated whirlwind of legislation this year. But odds are, hell be pretty boring.

https://www.kiplinger.com/article/business/T043-C012-S001-the-franken-factor.html

Source for information on extrinsic factor: A Dictionary of Food and Nutrition dictionary. ... Factor Viii , Factor VIII (antihaemophilic factor) One of the blood clotting factors. Factor VIII is a soluble protein that ... Limiting Factor , Limiting factor Limiting factors are environmental influences that constrain the productivity of organisms, ... stimulates the activation of Factor X b… Factors , FACTORS People who are employed by others to sell or purchase goods, who are ...

https://www.encyclopedia.com/education/dictionaries-thesauruses-pictures-and-press-releases/extrinsic-factor

growth factor* Any of various chemicals, particularly polypeptides, that have a variety of important roles in the stimulation ... Specific growth factors can cause new cell proliferation (epidermal growth factor, insulin-like growth factor, haemopoietic ... fibroblast growth factor) and play a role in wound healing (platelet-derived growth factor; PDGF). Some growth factors act in ... growth factor (grohth) n. a polypeptide that is produced by cells and stimulates them to proliferate. Some are involved in the ...

https://www.encyclopedia.com/medicine/anatomy-and-physiology/anatomy-and-physiology/growth-factor

The X Factor was based on a British program created by American Idol judge Simon Cowell, but, unlike the similar Australian ... Brisbane rhythm and blues group Random won the X-Factor reality TV competition just last night and already theyve got a ...

https://www.theage.com.au/entertainment/music/touring-with-x-factor-20050517-ge06bs.html

These factors include polysaccharide capsules and M proteins that impede phagocytosis, enzymes that degrade host tissues, and ... produce a variety of so-called virulence factors that permit them to evade the defense mechanisms of the host and thus cause ... Other articles where Virulence factor is discussed: necrotizing fasciitis: … ... Virulence factor. microbiology. Learn about this topic in these articles:. necrotizing fasciitis. * In necrotizing fasciitis. … ...

https://www.britannica.com/science/virulence-factor

Three months ago Max Factor announced a collaboration with the latest Star Wars film, Star Wars Episode VII: The Force Awakens. ... Behind the scenes shots of the looks being created Credit: Max Factor ... Its time we all explored our own light and dark sides, say Max Factor. ...

https://www.telegraph.co.uk/beauty/make-up/Max-Factor-Star-Wars-Pat-McGrath/

Contamination Factors. Factors that introduce or otherwise permit contamination; contamination factors relate to how the ... Survival Factors (Primarily bacterial outbreaks):. Factors that allow survival or fail to destroy or inactivate the contaminant ... This factor would typically be cited along with another contamination factor, such as C6 or C7. ... Proliferation/Amplification Factors (Bacterial outbreaks only):. Factors that allow proliferation or amplification of the ...

https://www.cdc.gov/nceh/ehs/nears/cf-definitions.htm

... is a short-term solution; most companies factor for two years or less. Plant says the factors role is to help ... Still, plenty of misperceptions about factoring remain.. Factoring is not a loan; it does not create a liability on the balance ... One of the oldest forms of business financing, factoring is the cash-management tool of choice for many companies. Factoring is ... Yes, when you compare the discount rate factors charge against the interest rate banks charge, factoring costs more. But if you ...

https://www.entrepreneur.com/encyclopedia/factoring

BOYD, W., LATTER, J. & ROBSON, W. Growth Factors. Nature 127, 308 (1931). https://doi.org/10.1038/127308e0 ...

https://www.nature.com/articles/127308e0?error=cookies_not_supported&code=c56f3af7-1f37-492d-928b-64634fe662b4

Been using Two factor authentication (2FA) (Via extension) on my forum for a year or more now. I agree, it should be built in ... Been using Two factor authentication (2FA) (Via extension) on my forum for a year or more now. I agree, it should be built in ... Been using Two factor authentication (2FA) (Via extension) on my forum for a year or more now. I agree, it should be built in ... Been using Two factor authentication (2FA) (Via extension) on my forum for a year or more now. I agree, it should be built in ...

https://www.phpbb.com/community/viewtopic.php?f=436&t=2438306

... Donald R. Davis, David E. Weinstein. NBER Working Paper No. 8637. Issued in December 2001. NBER ... w8516 Do Factor Endowments Matter for North-North Trade?. Davis and Weinstein. w8543 What Role for Empirics in International ... Study of the factor content of trade has become a laboratory to test our ideas about how the key elements of endowments, ... This work should provide a more substantial foundation for future policy work developed within a factor content framework. ...

http://www.nber.org/papers/w8637

... with a number of changes celebrating the best of The X Factor including brand new double auditions and the welcome return of a ...

https://www.itv.com/presscentre/ep6week38/x-factor

The family factor. BMJ 2013; 346 doi: https://doi.org/10.1136/bmj.f3740 (Published 14 June 2013) Cite this as: BMJ 2013;346: ...

http://www.bmj.com/content/346/bmj.f3740

Other articles where Rh factor is discussed: therapeutics: Blood and blood cells: Most individuals are Rh-positive, which means ... Rh antigen, often called the Rh factor, on the cell membranes of the red blood cells (erythrocytes). The designation Rh is ... The determination of the Rh (from rhesus) factor in human blood involves reaction with the blood of this monkey, and a rhesus ... have circulating antibodies against the Rh factor. These antibodies can cross the placenta and destroy the red blood cells of ...

https://www.britannica.com/science/Rh-factor

Factor X deficiency is a rare bleeding disorder that varies in severity among affected individuals. Explore symptoms, ... The inherited form of factor X deficiency, known as congenital factor X deficiency, is caused by mutations in the F10 gene, ... Factor X deficiency: clinical manifestation of 102 subjects from Europe and Latin America with mutations in the factor 10 gene ... Some F10 gene mutations that cause factor X deficiency reduce the amount of coagulation factor X in the bloodstream, resulting ...

https://medlineplus.gov/genetics/condition/factor-x-deficiency/

Ray Lewis and the X-factor. Make that the Rex factor. ...

https://www.baltimoresun.com/news/bs-xpm-2009-01-10-0901110077-story.html

Hillary reminds me of a couple of girls I knew in high school. They were the ones who figured out their grade-point averages on a nightly basis. They also were the ones who ran for everything - class president, president of the Hi-Y, captain of ...

https://www.nationalreview.com/2007/03/likeability-factor-myrna-blyth/

... of the factor XI protein, which is involved in blood clotting. Explore symptoms, inheritance, genetics of this condition. ... Factor XI deficiency is a disorder that can cause abnormal bleeding due to a shortage (deficiency) ... Most cases of factor XI deficiency are caused by mutations in the F11 gene, which provides instructions for making the factor ... Because factor XI is made primarily by cells in the liver. , acquired factor XI deficiency can also occur as the result of ...

https://medlineplus.gov/genetics/condition/factor-xi-deficiency/

See an archive of all x factor stories published on the New York Media network, which includes NYMag, The Cut, Vulture, and ... Demi Lovatos X Factor Beauty Transformation. From My Little Pony hair to a Jackie O. beehive, with a rainbow of eye shadow to ... On The X Factor UK, Lady Gaga performed "Marry the Night" from inside what appeared to be a very tall womans dead body, post- ... Accident During The X Factor Finale Injures 3 Stagehands. A stair riser unhinged, knocking two crew members in the head and one ...

http://nymag.com/tags/x-factor/

Sinister has disappeared and Cyclops is given his old job. Havoks jealousy grows. How will this affect the brothers relationship and what does it hold for the future of Apocalypses army?

https://www.marvel.com/comics/issue/20045/factor_x_1995_2

MULTI-FACTOR AUTHENTICATION MEMORIAL FACTOR Memorial factor * 27. MULTI-FACTOR AUTHENTICATION PHYSICAL FACTOR Memorial factor ... MULTI-FACTOR AUTHENTICATION PHYSICAL FACTOR Memorial factor Physical Factor * 29. MULTI-FACTOR AUTHENTICATION PHYSICAL FACTOR ... MULTI-FACTOR AUTHENTICATION PHYSICAL FACTOR Memorial factor Physical Factor * 31. MULTI-FACTOR AUTHENTICATION PHYSICAL FACTOR ... MULTI-FACTOR AUTHENTICATION PHYSICAL FACTOR Memorial factor Physical Factor * 33. MULTI-FACTOR AUTHENTICATION PHYSICAL FACTOR ...

https://www.slideshare.net/PhilippeGamache/multi-factor-authetification-zendcon-2017

Scatter factor/hepatocyte growth factor is essential for liver development. Nature. 1995;373(6516):699-702.PubMedCrossRefGoogle ... Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. 1991b;10(10):2867-78. ... Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol. 1992 ... Powell EM, Mars WM, Levitt P. Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral ...

https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_101684

Appearing as a guest on Friday's The O'Reilly Factor , FNC correspondent Geraldo Rivera declared that 'you've got to be a nut to get the Republican nomination,' and that Republicans 'have a suicide complex' as he responded to host Bill O'Reilly recalling that Hillary Clinton's campaign has already started characterizing GOP presidential candidate Donald Trump as a 'nut. (newsbusters.org)
On this evening's O'Reilly Factor , Geraldo Rivera scolded guest host Eric Bolling for pronouncing the state of Nevada as Ne-VA-da. (newsbusters.org)
The Media Research Center's Director of Media Analysis Tim Graham made his latest appearance on the Fox News Channel (FNC) program The O'Reilly Factor Tuesday night for what was quite the lively segment with fill-in host Eric Bolling and ETWN correspondent Lauren Ashburn as Graham and Bolling spared with Ashburn over the media's obsession with Donald Trump and double standard when it comes to exposing lies by Hillary Clinton. (newsbusters.org)
Fox was led by The O'Reilly Factor, which notched its 60th consecutive quarter as the No. 1 show in both categories. (aim.org)
Stossel Mentioned Us on the O'Reilly Factor! (aim.org)
Tuesday evening on The O'Reilly Factor, John Stossel mentioned media coverage and dropped our name! (aim.org)
The O'Reilly Factor is growing steadily with more and more viewers tuning in. (everything2.com)
Bill has since written two books, the aptly titled The O'Reilly Factor and The No Spin Zone , to date and he is also a columnist for WorldNet Daily News. (everything2.com)

There are two commercially available Factor X concentrates: "Factor X P Behring" manufactured by CSL Behring , [7] and high purity Factor X "Coagadex" produced by Bio Products Laboratory and approved for use in the United States by the FDA in October 2015 and in the EU on 16th March 2016 after earlier acceptance by CHMP and COMP. (wikipedia.org)

Factor Xa is inactivated by protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). (wikipedia.org)
The affinity of this protein for factor Xa is increased 1000-fold by the presence of protein Z , while it does not require protein Z for inactivation of factor XI . (wikipedia.org)
Defects in protein Z lead to increased factor Xa activity and a propensity for thrombosis. (wikipedia.org)
To date, 191 crystal structures of factor Xa with various inhibitors have been deposited in the protein data bank. (wikipedia.org)
The factor Xa protease can be used in biochemistry to cleave off protein tags that improve expression or purification of a protein of interest. (wikipedia.org)
The inherited form of factor X deficiency, known as congenital factor X deficiency, is caused by mutations in the F10 gene, which provides instructions for making a protein called coagulation factor X. This protein plays a critical role in the coagulation system, which is a series of chemical reactions that forms blood clots in response to injury. (medlineplus.gov)
Some F10 gene mutations that cause factor X deficiency reduce the amount of coagulation factor X in the bloodstream, resulting in a form of the disorder called type I. Other F10 gene mutations result in the production of a coagulation factor X protein with impaired function, leading to type II factor X deficiency. (medlineplus.gov)
Factor XI deficiency is a disorder that can cause abnormal bleeding due to a shortage (deficiency) of the factor XI protein, which is involved in blood clotting. (medlineplus.gov)
This condition is classified as either partial or severe based on the degree of deficiency of the factor XI protein. (medlineplus.gov)
Most cases of factor XI deficiency are caused by mutations in the F11 gene, which provides instructions for making the factor XI protein. (medlineplus.gov)
It can be caused by other disorders such as conditions in which the immune system malfunctions and attacks the factor XI protein. (medlineplus.gov)
Rh factor, protein substance present in the red blood cells of most people, capable of inducing intense antigenic reactions. (factmonster.com)
Factor V Leiden is a variant of the protein Factor V (5), which is needed for blood clotting. (netdoctor.co.uk)
Rhesus factor, more commonly referred to as Rh factor, is a protein, more commonly an antigen, that exists on a red blood cell's surface. (brighthub.com)

A non-inherited form of the disorder, called acquired factor X deficiency, is more common than the congenital form. (medlineplus.gov)

For other uses, see Factor X (disambiguation) . (wikipedia.org)

Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as intrinsic Xase ) and factor VII with its cofactor, tissue factor (a complex known as extrinsic Xase ). (wikipedia.org)
Factor VIII, also known as anti-hemophilic factor , is an essential blood-clotting factor that is deficient or absent in people with hemophilia . (daviddarling.info)
The factor VIII assay is a blood test that measures the activity of factor VIII. (daviddarling.info)
High potency factor VIII concentrates. (bmj.com)

Merriam-Webster.com Thesaurus , Merriam-Webster, https://www.merriam-webster.com/thesaurus/factor. (merriam-webster.com)

For example, epidermal growth factor (EGF) enhances osteogenic differentiation, [2] while fibroblast growth factors and vascular endothelial growth factors stimulate blood vessel differentiation ( angiogenesis ). (wikipedia.org)
Epidermal growth factor (EGF-)-like family members bind to and activate EGF receptor tyrosine kinases ErbB-1, −2, −3, and −4, also named HER1-4. (springer.com)
Epidermal Growth Factor- (EGF-) like family consists of at least twelve members: Epidermal growth factor (EGF), transforming growth factor alpha (TGFα), heparin binding-EGF like growth factor (HB-EGF), amphiregulin(AR), betacellulin (BTC), epiregulin (EPR), epigen, cripto, and neuregulins 1-4 (NRG1-4). (springer.com)
These EGF-like members are defined by three characteristics: (a) they display high affinity binding to membrane-bound epidermal growth factor tyrosine. (springer.com)
Dong J, Wiley HS (2000) Trafficking and proteolytic release of epidermal growth factor receptor ligands are modulated by their membrane-anchoring domains. (springer.com)

Hepatocyte growth factor as an enhancer of nmda currents and synaptic plasticity in the hippocampus. (springer.com)
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. (springer.com)
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. (springer.com)
Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration. (springer.com)
Ieraci A, Forni PE, Ponzetto C. Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development. (springer.com)
Hepatocyte growth factor overexpression in the nervous system enhances learning and memory performance in mice. (springer.com)
Maina F, Klein R. Hepatocyte growth factor, a versatile signal for developing neurons. (springer.com)
The 'official' TCF1 (transcription factor 1) is hepatocyte nuclear factor 1 (HNF1, a homeobox transcription factor involved in regulating liver-specific genes and mutated in maturity onset diabetes of the young. (oxfordreference.com)

Square-free factorization The following steps do not work whether there are repeated things, so the very first step is to factor the polynomial in such a manner there are no repeated elements. (google.com)
A mapping from a given factoring problem to a positive degree four polynomial F is described. (microsoft.com)

Acquired factor X deficiency is not inherited, and generally occurs in individuals with no history of the disorder in their family. (medlineplus.gov)
The acquired form of factor XI deficiency is not inherited and does not run in families. (medlineplus.gov)

Diagnosis and treatment of inherited factor X deficiency. (medlineplus.gov)

Only you can answer why you need two-factor authentication and what you want that other factor to be. (techtarget.com)

for example, nerve growth factor stimulates the growth of axons and dendrites from developing sensory and sympathetic neurons. (encyclopedia.com)
growth factor (grohth) n. a polypeptide that is produced by cells and stimulates them to proliferate. (encyclopedia.com)

The alpha granules in blood platelets contain growth factors PDGF, IGF-1, EGF, and TGF-β which begin healing of wounds by attracting and activating macrophages , fibroblasts , and endothelial cells . (wikipedia.org)

Factor X , also known by the eponym Stuart-Prower factor , is an enzyme ( EC 3.4.21.6 ) of the coagulation cascade . (wikipedia.org)

Read on the learn more about the genetics of Rhesus factor. (brighthub.com)
This led to the understanding of the genetics of Rhesus factor. (brighthub.com)
The genetics of Rhesus factor play a major role in whether a child is born with Rhesus factor. (brighthub.com)

Study of the factor content of trade has become a laboratory to test our ideas about how the key elements of endowments, production, absorption and trade fit together within a general equilibrium framework. (nber.org)
This work should provide a more substantial foundation for future policy work developed within a factor content framework. (nber.org)
Glen Campbell, Executive Vice President and head of Elsevier's health sciences journals said of the results, "These significant Impact Factor increases, as well as those in more than 61% of our medical journals, reflect the dedication of our editors, reviewers, and authors, the high quality of our editorial content and our sharpened focus on author services. (elsevier.com)

The Rh, or rhesus, factor was discovered in 1940 by K. Landsteiner and A. S. Wiener, when they observed that an injection of blood from a rhesus monkey into rabbits caused an antigenic reaction in the serum component of rabbit blood (see immunity ). (factmonster.com)

IBM Z MFA supports a wide range of authentication systems including: RADIUS-based factors, timed one-time password (TOTP) such as IBM Verify and TouchToken, certificate authentication (PIV/CAC users), and proprietary protocols such as RSA. (ibm.com)
I set-up the plugin with just TOTP authentication but I can't find the TOTP Factor Setup to add my device. (moodle.org)

Rh antigen, often called the Rh factor , on the cell membranes of the red blood cells (erythrocytes). (britannica.com)
It is only when the two blood types are mingled in an Rh-negative individual that the difficulty arises, since the Rh factor acts as an antigen in Rh-negative persons, causing the production of antibodies. (factmonster.com)
People who have the antigen in their blood, or Rh factor, are deemed Rh-positive. (brighthub.com)
People who do not have the antigen, or are without the Rhesus factor, are Rh-negative. (brighthub.com)

Apoptosis by death factor. (nih.gov)
Secreted growth factors bind to transmembrane growth factor receptors to stimulate cell signalling cascades that promote proliferation, apoptosis and differentiation. (nature.com)

Individual growth factor proteins tend to occur as members of larger families of structurally and evolutionarily related proteins. (wikipedia.org)
Apart from congenital deficiency, low factor X levels may occur occasionally in a number of disease states. (wikipedia.org)
In contrast to some other bleeding disorders, spontaneous bleeding into the urine (hematuria), gastrointestinal tract, or skull cavity are not common in factor XI deficiency, although they can occur in severely affected individuals. (medlineplus.gov)
acquired factor XI deficiency can also occur as the result of severe liver disease or receiving a transplanted liver from an affected individual. (medlineplus.gov)
Customers can also filter their meal choices by allergens, but Factor 75 say that they cannot guarantee that cross-contamination will not occur in their kitchens. (medicalnewstoday.com)
Bug 105056 noted a problem that can occur during a rolling upgrade if two factor authentication is enabled before all mailbox servers have been upgraded to 8.7. (zimbra.com)

Next month marks a bit of a watershed in this regard, with the U.S. premiere of two U.K. imports that ratchet up the fear factor. (variety.com)
Hey all, Anyone here remember Fear Factor? (collegenet.com)
Fear Factor - I was amazed at the things people did on that show. (collegenet.com)
Greetings murasaki, Fear Factor used to be my favorite show! (collegenet.com)

If one factor is a covariate, the interaction is illustrated by different regression slopes at each level of the categorical factor. (soton.ac.uk)

Factor Xa inhibitors generally bind in an L-shaped conformation, where one group of the ligand occupies the anionic S1 pocket lined by residues Asp189, Ser195, and Tyr228, and another group of the ligand occupies the aromatic S4 pocket lined by residues Tyr99, Phe174, and Trp215. (wikipedia.org)

Growth factors typically act as signaling molecules between cells. (wikipedia.org)
The factor (the funding source) buys the right to collect on that invoice by agreeing to pay you the invoice's face value less a discount--typically 2 to 6 percent. (entrepreneur.com)
Factors also provide services banks do not: They typically take over a significant portion of the accounting work for their clients, help with credit checks, and generate financial reports to let you know where you stand. (entrepreneur.com)
But as investors have also experienced, as certain styles or themes go out of favor, factors typically go through periods (and potentially extended periods) of underperformance. (foxbusiness.com)

Factor V Leiden only slightly increases the risk of getting a blood clot and many people with this condition will never experience thrombosis. (netdoctor.co.uk)
A recent study uncovers a new risk factor that might help explain these increases. (medicalnewstoday.com)

Growth factor signalling is a cell signalling pathway that regulates the growth and development of an organism. (nature.com)

Girolami A, Scarparo P, Scandellari R, Allemand E. Congenital factor X deficiencies with a defect only or predominantly in the extrinsic or in the intrinsic system: a critical evaluation. (medlineplus.gov)
Girolami A, Vettore S, Scarparo P, Lombardi AM. Persistent validity of a classification of congenital factor X defects based on clotting, chromogenic and immunological assays even in the molecular biology era. (medlineplus.gov)
Karimi M, Menegatti M, Afrasiabi A, Sarikhani S, Peyvandi F. Phenotype and genotype report on homozygous and heterozygous patients with congenital factor X deficiency. (medlineplus.gov)

In Britain, 5 per cent of the population carry one or more genes for Factor V Leiden, which is far more than the number of people who will actually suffer from thrombosis. (netdoctor.co.uk)
The genes for the Factor V are passed on from our parents. (netdoctor.co.uk)
or two Factor V Leiden genes. (netdoctor.co.uk)
Having one Factor V Leiden gene will result in a slightly higher risk of developing a thrombosis, but having two genes makes the risk much greater. (netdoctor.co.uk)
Women carrying two genes for Factor V Leiden will need to receive treatment with a heparin anticoagulant medicine during pregnancy . (netdoctor.co.uk)

Growth factors" redirects here. (wikipedia.org)
For the journal, see Growth Factors (journal) . (wikipedia.org)
Growth factors are important for regulating a variety of cellular processes. (wikipedia.org)
They often promote cell differentiation and maturation, which varies between growth factors. (wikipedia.org)
While some cytokines can be growth factors, such as G-CSF and GM-CSF , others have an inhibitory effect on cell growth or proliferation. (wikipedia.org)
It is thought that some growth factors are involved in the abnormal regulation of growth seen in cancer when produced in excessive amounts. (encyclopedia.com)

Therefore in our view we need to talk about our wood management before any other factor in the maturation of The Macallan. (dictionary.com)

These factors include polysaccharide capsules and M proteins that impede phagocytosis, enzymes that degrade host tissues, and toxins that overstimulate the immune system, causing fever and shock. (britannica.com)
Acquired factor X deficiency can be caused by other disorders such as severe liver disease or systemic amyloidosis, a condition involving the accumulation of abnormal proteins called amyloids. (medlineplus.gov)

Cell , the flagship journal of Cell Press, remains the number one research journal in the Cell Biology and Biochemistry & Molecular Biology subject categories, with an Impact Factor of 31.152. (elsevier.com)

A family of transcription factors (lymphoid enhancer-binding factor (LEF), LEF/TCFs) that are important in the wnt/β-*catenin signalling cascade. (oxfordreference.com)

IBM Z MFA works with the RACF Security Server infrastructure to create a layered defense by requiring selected z/OS users to logon with multiple authentication factors. (ibm.com)

Researchers suggest that the actual prevalence of factor XI deficiency may be higher than reported, because mild cases of the disorder often do not come to medical attention. (medlineplus.gov)
Carotid web may be an underappreciated risk factor for stroke," the researchers say. (medscape.com)
In the JAMA study, researchers looked at the survival and mortality rates of 542,008 heart attack patients and discovered that half of patients presented with less than two of the five major risk factors: high-blood pressure, smoking, high cholesterol, a family history, and diabetes. (menshealth.com)
In an alarming reveal, researchers found patients who with few or no risk factors had higher rates of death after the first heart attack. (menshealth.com)

Patients who didn't have any of the five major risk factors might have had a different risk factor (like elevated calcium score or insulin resistance and metabolic syndrome) or a risk that was below detection, Dr. Canto explains. (menshealth.com)

Founded in 1982, FACTOR has been administering public money since 1986. (wikipedia.org)

Inui S, Higashiyama S, Hashimoto K, Higashiyama M, Yoshikawa K, Taniguchi N (1997) Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth. (springer.com)

The first crystal structure of human factor Xa was deposited in May 1993. (wikipedia.org)

Deficiency of vitamin K or antagonism by warfarin (or similar medication) leads to the production of an inactive factor X. In warfarin therapy, this is desirable to prevent thrombosis . (wikipedia.org)
People carrying the Factor V Leiden gene have a five times greater risk of developing a blood clot (thrombosis) than the rest of the population. (netdoctor.co.uk)
Since these clots are formed in the veins that take blood to the heart and not in the arteries (which take blood from the heart), Factor V Leiden does not increase the risk of coronary thrombosis . (netdoctor.co.uk)
Women carrying the Factor V Leiden gene should not take the contraceptive pill because this will significantly increase the chance of getting thrombosis. (netdoctor.co.uk)
Women carrying the Factor V Leiden gene should also consult their doctor before becoming pregnant as this can also increase the risk of thrombosis. (netdoctor.co.uk)

The other major difference is that we support multiple authentication factor types as sub plugins, eg IP Range, Email, TOPT and in future others such as SMS or hardware tokens or anything else as new sub-plugins. (moodle.org)

have circulating antibodies against the Rh factor . (britannica.com)

The money factor can be translated into the more common annual percentage rate (APR) by multiplying the money factor by 2,400. (investopedia.com)
While the decimal version is more common, a money factor that is a whole number can still be converted to an APR by multiplying it by 2.4. (investopedia.com)
Some common macroeconomic factors include credit, inflation, and liquidity whereas style factors embrace style, value, and momentum, just to name a few. (investopedia.com)
Factoring is very common in certain industries, such as the clothing industry, where long receivables are part of the business cycle. (entrepreneur.com)
The sole general rule is to attempt to group and attempt to discover common factors so to more group and simplify. (google.com)
The best common factor of a set of numbers is the greatest factor that is normal to every one of the numbers. (google.com)
Diabetes was more common in cases (10 of 53 [19.2%]) than controls (7 of 102 [6.9%]), but there was no difference in prevalence of 3 other atherosclerotic risk factors (hypertension, dyslipidemia, and coronary artery disease). (medscape.com)
See our FAQ for answers to common questions about Multi-Factor Authentication at UVM. (uvm.edu)

Research suggests that other factors such as smoking, being exposed to chemicals that can cause cancer, and changes in other hormones due to night shift working also may increase breast cancer risk. (cdc.gov)

The factoring of biprimes is proposed as a framework for exploring unconstrained optimization algorithms. (microsoft.com)

Reduced quantity or function of coagulation factor X prevents blood from clotting normally, causing episodes of abnormal bleeding that can be severe. (medlineplus.gov)

See the new Intel® SSD form factor that's in perfect harmony with the data center and brings a new standard of drive capacity, scalability, and operational efficiency while being free from legacy drive constraints. (intel.com)
A payment device, method, and apparatus configured to determine the form factor of the payment device used in a financial transaction, without requiring a different primary account number for each payment device form factor. (freepatentsonline.com)
and a device indicator configured to indicate a form factor of the payment device. (freepatentsonline.com)
and either transmitting the form factor indicator to a payment processor or storing the form factor indicator in a form factor log database. (freepatentsonline.com)
a data processor configured to either transmit the form factor indicator to a payment processor via a network interface or to store the form factor indicator in a form factor log database. (freepatentsonline.com)

Who is IBM Z Multi-Factor Authentication for? (ibm.com)
How does IBM Z Multi-Factor Authentication work with RACF? (ibm.com)
What additional factors does IBM Z Multi-Factor Authentication work with? (ibm.com)
What are the system requirements for IBM Z Multi-Factor Authentication? (ibm.com)
What is multi-factor authentication (MFA) or 2FA? (ibm.com)
Duo Security is a multi-factor authentication tool used by the University of Vermont to protect sensitive information. (uvm.edu)
At this point you should be able to use Duo to access multi-factor protected services. (uvm.edu)

The human factor X gene is located on chromosome 13 (13q34). (wikipedia.org)
Here are some tips to help you successfully navigate the unforeseen human factor that all too-often comes into play when trying to make and close a deal. (thenextweb.com)

Factor X is synthesized in the liver and requires vitamin K for its synthesis. (wikipedia.org)

Inborn deficiency of factor X is very rare (1:1,000,000), and may present with epistaxis (nosebleeds), hemarthrosis (bleeding into joints) and gastrointestinal blood loss. (wikipedia.org)
The determination of the Rh (from rhesus) factor in human blood involves reaction with the blood of this monkey, and a rhesus was the first monkey to be rocketed into the stratosphere. (britannica.com)
Factor X deficiency commonly causes nosebleeds, easy bruising, bleeding under the skin, bleeding of the gums, blood in the urine (hematuria), and prolonged or excessive bleeding following surgery or trauma. (medlineplus.gov)
The blood of the remaining 15% lacked the factor and was typed Rh negative. (factmonster.com)
People who have a Factor V deficiency are more likely to bleed badly while people with Factor V Leiden have blood that has an increased tendency to clot. (netdoctor.co.uk)
The gene for Factor V Leiden can be found in a blood sample . (netdoctor.co.uk)
People with Factor V Leiden do not need treatment unless their blood starts to clot, in which case the doctor will prescribe blood-thinning (anticoagulant) medicines, such as warfarin (eg Marevan) or heparin, to prevent further clots. (netdoctor.co.uk)
The same applies to women carrying just one gene for Factor V Leiden who have previously had a blood clot themselves or who have a family history of blood clots. (netdoctor.co.uk)
The Rhesus factor is what determines whether our blood is classified as positive or negative. (brighthub.com)
Each of these blood types is further classified as negative or positive, which is a reference to the blood's Rhesus factor. (brighthub.com)
TCF4 (T-cell transcription factor 4, TCF7-like 2) is implicated in blood glucose homeostasis. (oxfordreference.com)

Being a woman and getting older are the main risk factors for breast cancer. (cdc.gov)
The main factors that influence your risk include being a woman and getting older. (cdc.gov)
A treatment main effect can be interpreted independently of its interactions with other factors only if the others are random factors. (soton.ac.uk)
A fully replicated design with two cross factors can have eight alternative outcomes in terms of the significance of its main effects and interactions. (soton.ac.uk)

Factor 75 enter their meals into apps such as MyFitnessPal and Carb Manager, which may make it easy for customers to track their nutrient intake. (medicalnewstoday.com)
In this course, join Frank Moley as he walks through the twelve factors that go into building agile, highly-scalable, and resilient web apps. (lynda.com)
The Two Factor authentication wizard will show a Wiki link with the OTP Apps Zimbra recommends to use. (zimbra.com)

What Are the Risk Factors for Breast Cancer? (cdc.gov)
Studies have shown that your risk for breast cancer is due to a combination of factors. (cdc.gov)
Some women will get breast cancer even without any other risk factors that they know of. (cdc.gov)
Having a risk factor does not mean you will get the disease, and not all risk factors have the same effect. (cdc.gov)
Most women have some risk factors, but most women do not get breast cancer. (cdc.gov)
If you have breast cancer risk factors, talk with your doctor about ways you can lower your risk and about screening for breast cancer. (cdc.gov)
These are called risk factors. (cdc.gov)
Many risk factors can be changed or modified to help prevent falls. (cdc.gov)
Most falls are caused by a combination of risk factors. (cdc.gov)
The more risk factors a person has, the greater their chances of falling. (cdc.gov)
Healthcare providers can help cut down a person's risk by reducing the fall risk factors listed above. (cdc.gov)
Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly. (cdc.gov)
From basic information about cancer and its causes to in-depth information on specific cancer types - including risk factors, early detection, diagnosis, and treatment options - you'll find it here. (cancer.org)
Some risk factors have a direct role in causing cancer, but in other cases the risk may be due to something else that goes along with the risk factor. (cancer.org)
Different cancers have different risk factors. (cancer.org)
Some risk factors, such as smoking, can be controlled. (cancer.org)
Factor investing, from a theoretical standpoint, is designed to enhance diversification, generate above-market returns and manage risk. (investopedia.com)
Rather than look at complex attributes, such as momentum, beginners to factor investing can focus on simpler elements, such as style (growth vs. value), size (large cap vs. small cap), and risk (beta). (investopedia.com)
Women with factor X deficiency can have heavy or prolonged menstrual bleeding (menorrhagia) or excessive bleeding in childbirth, and may be at increased risk of pregnancy loss (miscarriage). (medlineplus.gov)
Only women who are Rh-negative are at risk for giving birth to a child with Rhesus factor disease. (brighthub.com)
A recent study investigates a new risk factor for mouth cancer. (medicalnewstoday.com)
Although scientists have confirmed some risk factors, there is still much to learn about how and why mouth cancer affects certain individuals and not others. (medicalnewstoday.com)
Recently, scientists set out to investigate another potential risk factor: air pollution. (medicalnewstoday.com)
After taking a range of influencing factors into account, the scientists demonstrated that exposure to PM2.5 also increased mouth cancer risk. (medicalnewstoday.com)
You're probably wondering why obesity wasn't considered a risk factor. (menshealth.com)
If you have any risk factors for heart disease, make sure to get them under control. (menshealth.com)

The impact factor is a measure of the frequency with which the average article in a journal has been cited in a particular year. (elsevier.com)

The addition of new identification factor allows to solve this problem. (slideshare.net)
In this session we'll see the concepts of strong authentication, the introduction of alternative free or low cost second-factor identification. (slideshare.net)
Two-factor authentication is a technology that provides identification of users with the combination of two different components. (zimbra.com)

Anatomy1

Organisms3

Diseases3

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes8

Information Science2

Evidence suggesting the regulation of a coagulation factor levels in rabbits by a transferable plasma agent. (1/674)

Plasmin converts factor X from coagulation zymogen to fibrinolysis cofactor. (2/674)

Coagulation factors II, V, VII, and X, prothrombin gene 20210G-->A transition, and factor V Leiden in coronary artery disease: high factor V clotting activity is an independent risk factor for myocardial infarction. (3/674)

Domain identification of hormone-sensitive lipase by circular dichroism and fluorescence spectroscopy, limited proteolysis, and mass spectrometry. (4/674)

The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity. (5/674)

Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage. (6/674)

Dietary lipid lowering reduces tissue factor expression in rabbit atheroma. (7/674)

"Normal" thrombin generation. (8/674)

Factor X

Factor Xa

Factor IXa

Factor IX

Factor VIIa

Hypoprothrombinemias

Thromboplastin

Prothrombin

Factor VIIIa

Factor VII

Blood Coagulation

1-Carboxyglutamic Acid

Factor VIII

Blood Coagulation Factors

Vitamin K

Blood Coagulation Tests

Thrombin

Snake Venoms

Dysprosium

Coagulants

Viper Venoms

Kinetics

Factor Va

Antithrombin III

Cattle

Phospholipids

Partial Thromboplastin Time

Factor V

Ytterbium

Prothrombin Time

Amino Acid Sequence

Phosphatidylserines

Factor VII Deficiency

X Chromosome

Warfarin

Carbon-Carbon Ligases

Peptide Fragments

Molecular Sequence Data

Antithrombins

Binding Sites

Blood Coagulation Disorders

Protein Binding

Electrophoresis, Polyacrylamide Gel

Samarium

Protein S

Protein C

Factor XIa

Benzamidines

Viperidae

Snakes

Recombinant Proteins

Anticoagulants

Evidence suggesting the regulation of a coagulation factor levels in rabbits by a transferable plasma agent. (1/674)

Plasmin converts factor X from coagulation zymogen to fibrinolysis cofactor. (2/674)

Coagulation factors II, V, VII, and X, prothrombin gene 20210G-->A transition, and factor V Leiden in coronary artery disease: high factor V clotting activity is an independent risk factor for myocardial infarction. (3/674)

Domain identification of hormone-sensitive lipase by circular dichroism and fluorescence spectroscopy, limited proteolysis, and mass spectrometry. (4/674)

The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity. (5/674)

Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage. (6/674)

Dietary lipid lowering reduces tissue factor expression in rabbit atheroma. (7/674)

"Normal" thrombin generation. (8/674)

Coagulation Factor X (Human) - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

Coagulation Factor X Kits: Novus Biologicals

LC2 - Snaclec coagulation factor X-activating enzyme light chain 2 precursor - Daboia siamensis (Eastern Russels viper) - LC2...

Human F10 (Coagulation Factor X) ELISA Kit | Quadratech Diagnostics

Natural Human Factor X protein (ab62549) | Abcam

Human Factor X - Creative Enzymes

growth factors x and v: post #1

MAX (Myc-Associated Factor X) [RP-122] - $260.00 : Excellgen, Recombinant Enzymes

Test Factor X Review - Free Testosterone Releasing Formula! - Perfect Muscle Supplement

Factor X Assay | Medical Tests | UCSF Health

Applications filed at Feb 23 2017 | HISTONE DEACETYLASE INHIBITORS | Patents.com

WikiGenes - F10 - coagulation factor X

Factor X | Profiles RNS

Browse - AMA Manual of Style

Cross-references - AMA Manual of Style

Factor X (Stuart factor) Causes, Purpose and more | Lab Tests Guide

Mutagenetix > Incidental...

TSNAX recombinant protein | Translin-Associated Factor X Recombinant Protein-NP 005990.1

Gentaur Molecular :Molecular Innovations \ Affinity Purified Sheep Anti Mouse Factor X \ SASMFX-GF-HT

Muscle Factor X Review - Do You Need More Energy for Your Workouts? - Supplements Watch

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