Ageusia: Complete or severe loss of the subjective sense of taste, frequently accompanied by OLFACTION DISORDERS.Tissue Transplantation: Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.Brain Tissue Transplantation: Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.Acellular Dermis: Remaining tissue from normal DERMIS tissue after the cells are removed.Complicity: Association with or participation in an act that is, or is perceived to be, criminal or immoral. One is complicitous when one promotes or unduly benefits from practices or institutions that are morally or legally suspect.Fetal Tissue Transplantation: Transference of fetal tissue between individuals of the same species or between individuals of different species.Personhood: The state or condition of being a human individual accorded moral and/or legal rights. Criteria to be used to determine this status are subject to debate, and range from the requirement of simply being a human organism to such requirements as that the individual be self-aware and capable of rational thought and moral agency.Directed Tissue Donation: Tissue, organ, or gamete donation intended for a designated recipient.Life: The state that distinguishes organisms from inorganic matter, manifested by growth, metabolism, reproduction, and adaptation. It includes the course of existence, the sum of experiences, the mode of existing, or the fact of being. Over the centuries inquiries into the nature of life have crossed the boundaries from philosophy to biology, forensic medicine, anthropology, etc., in creative as well as scientific literature. (Random House Unabridged Dictionary, 2d ed; Dr. James H. Cassedy, NLM History of Medicine Division)Beginning of Human Life: The point at which religious ensoulment or PERSONHOOD is considered to begin.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Aborted Fetus: A mammalian fetus expelled by INDUCED ABORTION or SPONTANEOUS ABORTION.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Kidney Transplantation: The transference of a kidney from one human or animal to another.Hospitals, State: Hospitals controlled by agencies and departments of the state government.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Hand Transplantation: The transference of a complete HAND, as a composite of many tissue types, from one individual to another.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Transplantation: Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Transplantation, Heterotopic: Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Transplantation Immunology: A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Heart Transplantation: The transference of a heart from one human or animal to another.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Pregnant Women: Human females who are pregnant, as cultural, psychological, or sociological entities.Primary Ovarian Insufficiency: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.Ethics, Medical: The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Cryopreservation: Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Transplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Transplants: Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.Islets of Langerhans Transplantation: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.Ovary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Living Donors: Non-cadaveric providers of organs for transplant to related or non-related recipients.Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Cell Transplantation: Transference of cells within an individual, between individuals of the same species, or between individuals of different species.Transplantation Chimera: An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Heart-Lung Transplantation: The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.Immunosuppression: Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.Transplantation, Isogeneic: Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.Waiting Lists: Prospective patient listings for appointments or treatments.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Histocompatibility Testing: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.Cord Blood Stem Cell Transplantation: Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).Transplantation Tolerance: An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.Cadaver: A dead body, usually a human body.Peripheral Blood Stem Cell Transplantation: Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.Recurrence: The return of a sign, symptom, or disease after a remission.Histocompatibility: The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Organizations: : O: Organ and Tissue Transplant - healthfinder.gov
Its mission is to facilitate the provision of transplantable tissues of uniform high qualities sufficient to meet national ... Organ Procurement and Transplantation Network The Organ Procurement and Transplantation Network (OPTN) is the unified ... United Network for Organ Sharing The United Network for Organ Sharing (UNOS) coordinates the nations organ transplant system, ... addresses the need for human organs and tissues for transplantation. A non-profit, federally designated Organ Procurement ...
Tissue Transplant History <...
... the history of tissue transplants have come a long way and can be credited for saving and improving many lives. Learn more, ... 1976: The American Association of Tissue Banks (AATB) was founded to facilitate the provision of transplantable tissue and ... developed methods of joining blood vessels utilizing vessels from a deceased donor that made the transplantation of organs ... Overview Organ Transplant Waiting List Transplant Centers Organ Transplant History How Tissue & Cornea Transplants Work Tissue ...
NY State Senate Bill S6952A
... coverage through the health benefit exchange to include registration space to register in the donate life registry for organ, ... This has resulted in a critical shortage of transplantable organs and tissue for New Yorkers in need of a lifesaving transplant ... SUMMARY OF PROVISIONS : Section 1 of the bill amends section 206 of the public health law to require that every application for ... Open Legislation comments facilitate discussion of New York State legislation. All comments are subject to moderation. Comments ...
Join the 67 percent of Coloradans and 59 percent of Wyoming citizens who have registered to be organ and tissue donors ... peer group organization founded in 1976 to facilitate the provision of transplantable cells and tissues of uniform high quality ... The Organ Procurement and Transplantation Network (OPTN) is the unified transplant network established by the United States ... United Network for Organ Sharing. Mission Statement: To advance organ availability and transplantation by uniting and ...
Ethical Controversies in Organ Donation After Circulatory Death | American Academy of Pediatrics
... perform solid organ transplants to develop protocols which address the required elements to facilitate the recovery of organs ... Policy statement-pediatric organ donation and transplantation. Pediatrics. 2010;125(4):822-828pmid:20351011. ... Registering wishes about organ and tissue donation: personal discussion during licence renewal may be superior to online ... Recent estimates suggest that DCD could increase the supply of transplantable organs by 20%.6 A number of subsequent reports ...
Solid Organ Transplantation in Singapore : Transplantation
NOTU also collects data on donor referrals, outcomes of organ/tissues procured, adverse events pertaining to organ transplant ... NOTU also facilitates meetings of the National Transplant Ethics Committee, the Advisory Committee on Transplantation in ... The transplantable organ shortage in Singapore: has implementation of presumed consent to organ donation made a difference. Ann ... Based on provisions by Medisave and Medishield, Singaporeans have a significant proportion of their healthcare expenditure ...
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Organ recovery techniques also have been adapted to facilitate use of older donors with significant aortic atherosclerosis [48 ... and the perception of inequitable access to medical care and organ transplant therapy have led to disappointingly low organ ... with the inherent risk of turning potential donors and transplantable organs into a commodity [59,60]. In the United States, ... but more distant tissue plane. This is known as a reverberation artifact and occurs when there is an air-tissue interface deep ...
Transplantation of the heart after circulatory death of the donor: time for a change in law? | The Medical Journal of Australia
In Victoria, the stated aim of the Human Tissue Act is to make provision for removal of human tissue for transplantation and, ... The withdrawal of treatment from the donor is staged to facilitate organ transplantation to recipients. The procurement of ... not the post-mortem function of any transplanted organ. We agree with the authors that the statutory definition of death in ... Australia has an increasing shortfall in transplantable hearts. Over the past decade, the number of all donors per million ...
Resource allocations and disparities in the Brazilian health care system: insights from organ transplantation services | BMC...
... organ transplantation services. We assess how equity challenges within the transplantation system can be explained by wider ... We suggest that Brazil needs to improve its health outcome measurement system for organ transplantations and epidemiological ... Finally, we recommend policy strategies to reduce barriers to access to transplantation services by increasing transplantation ... abilities to access organ transplantation services and receive quality treatment. In this article we evaluated the existing ...
IJMS | Free Full-Text | Wharton's Jelly-Derived Mesenchymal Stem Cells: Phenotypic Characterization and Optimizing Their ...
... is a gelatinous tissue within the umbilical cord that contains myofibroblast-like stromal cells. A unique cell population of WJ ... Among many tissue-originated multipotent stem cells, UCMSC may be suitable for allogenic transplantation as a therapeutic tool ... birth-associated tissues and adult organs. Based on biochemical and genomic markers, they can be broadly classified into ... and the strategy of sandwiching cells between two layers may facilitate scaffold and tissue integration . In short, WJ- ...
A nonimmune function of T cells in promoting lung tumor progression | Journal of Experimental Medicine | Rockefeller University...
T cells in facilitating tumor growth through provision of tissue maintenance factors, such as amphiregulin. We propose that the ... transplanted with LLC and EO771. At days 21-24 after transplantation, LLC tumors in lungs of AregFL/FL CD4-cre mice were ... ligand with important roles in organ development and tissue repair, was up-regulated in tumoral T cell populations. Using Lewis ... Using transplantable models of lung tumors in mice, we found that amphiregulin, a member of the epidermal growth factor family ...
Transcription factor‐mediated reprogramming toward hematopoietic stem cells | The EMBO Journal
From embryogenesis initiated by a single totipotent zygote to the lifelong homeostasis of organ parenchyma by tissue‐specific ... Although iPS cells have the developmental potential to be differentiated toward potentially transplantable autologous tissues, ... Siena S, Schiavo R, Pedrazzoli P, Carlo‐Stella C (2000) Therapeutic relevance of CD34 cell dose in blood cell transplantation ... Another major factor contributing to transplant success is the number of stem cells transplanted, with an increased number of ...
Utilisation of an embedded specialist nurse and collaborative care pathway increases potential organ donor referrals in the...
Transplantation 2003;75:1330-5.. OpenUrlCrossRefPubMedWeb of Science. *↵. National Health Service Blood and Transplant. ... that potential organ donors should be identified in the ED and embedded specialist nurses employed to facilitate organ donation ... with an average of three transplantable organs per donor being retrieved, transform the lives of over 600 patients currently ... Twenty-four hour provision of this service is provided via an on-call specialist nurse covering the region, contacted through a ...
... is a new tissue engineering and regenerative development aimed at providing organs for potential use in transplantation. Lung ... To avoid immune recipients rejection of the transplanted bioengineered lung, autologous bone marrow/adipose tissue-derived ... poses a challenge for improving our basic science knowledge and is also an opportunity for facilitating lung transplantation in ... The acellular lung scaffold is obtained by decellularizing a non-transplantable donor lung by means of conventional procedures ...
Islet Encapsulation: Physiological Possibilities and Limitations | Diabetes
Fetal porcine islet-like cell clusters transplanted to cynomolgus monkeys: an immunohistochemical study. Transplantation 1999; ... become revascularized and integrated with the surrounding tissues (49). Experience from clinical islet transplantation shows ... Generation of transplantable insulin-producing cells from human embryonic stem cells or induced pluripotent stem cells is at ... At present, there is no major shortage of primary human islets, i.e., those obtained from organ donors, to fulfill the current ...
Patent US6579256 - Instrument for subretinal implantation - Google Patents
... and choroidal transplantation while minimizing trauma to the transplanted tissues, the host eye and retina. It is believed that ... the provision of a graft for use in the reconstruction of a dystrophic retina; the provision of such a graft which facilitates ... Transplantable sheets of living keratinous tissue. US4393872. May 27, 1980. Jul 19, 1983. Eder Instrument Co., Inc.. Aspirating ... Del Priore, "Transplantation of Retinal Pigment Epithelium (RPE) Onto Bruchs Memebrane in Organ Culture", Suppl., Invest. ...
APPENDIX F Non-Heart-Beating Donation Protocols | Non-Heart-Beating Organ Transplantation: Practice and Protocols | The...
... to determine suitability for organ, tissue and eye donation, consistent with UPMCP Policy 5060, Organ and Tissue Donation. ... 9 transplanted).. However, as a significant shortage of cadaver organs for transplantation has persisted, many have proposed ... If narcotics and sedatives are administered, these drugs must be titrated to the patients need for provision of comfort. The ... successfully recover transplantable organs and recover costs. ... to facilitate infusion of peritoneal lavage. An second modified ...
Frontiers | Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic...
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Placental and Umbilical Cord Blood as a Source of Stem Cells - PDF
Biol Blood Marrow Transplant Gluckman E, Rocha V, Boyer-Chammard A et al. Outcome of cord-blood transplantation from related ... and storage of organ / tissue / cells; diagnostic services; drugs which require a prescription by federal law; medical and ... Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S ... Collection of the cells is painless, which facilitates recruitment and provides for a more ethnically diverse pool. Current ...
Mouse Embryonic Stem Cell Derivation, and Mouse and Human Embryonic Stem Cell Culture and Differentiation as Embryoid Bodies -...
... and tissue transplantation therapies for the repair and replacement of diseased, injured, and senescent tissue. Furthermore, ... of mouse ES cell counterparts from human blastocysts would enable the provision of an unlimited supply of tissue for cell ... Cell Transplant. 12:1‐11. Reubinoff, B.E., Pera, M.F., Fong, C.Y., Trounson, A., and Bongso, A. 2000. Embryonic stem cell lines ... Organ culture dishes treated with 0.1% (w/v) gelatin and coated with mitotically inactivated MEFs (see protocol 4. or protocol ...
Allen Cooper, MD | Stanford Medicine Profiles
The animals were then sacrificed and the tissues removed, dried, and the radioactivity measured to determine tissue uptake. An ... Tumors from the transplanted cells produced hepatic lipase localized to the surface of tumors from transfected cells but not ... Accelerated lipoprotein uptake by transplantable hepatomas that express hepatic lipase JOURNAL OF LIPID RESEARCH Donner, C., ... For LDL this may involve the provision of a second foot for particle binding, thus enhancing affinity for the LDL receptor. For ...
PubMed Kidney Transplant | Transplant Professional Portal
BACKGROUND: The immunosuppressant drugs (ISDs), tacrolimus and cyclosporine, are vital for solid organ transplant patients to ... This survey examined centre approaches to chronic kidney disease service provision, transplant recipient assessment, education ... and long-term graft outcomes were collected for women who were pregnant after renal transplantation and had transplant and ... a defect in tissue antioxidant capacity, and glutathione (GSH) depletion were also detected in the kidney of sulfasalazine- ...
Persufflation (gaseous oxygen perfusion) as a method of heart preservation | Journal of Cardiothoracic Surgery | Full Text
Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ... including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of ... need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation ... is an organ preservation technique with a potential for use in donor heart preservation. ...
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This tissues take been successfully transplanted art bases the blood victual to the nipple and between identical twins?It is ... It is limpid that autologous bone marrow or stem-cell transplantation has sometimes change the central basis of manipulation an ... It is the result of increased capillary swelling as the company attempts to provisioning more oxygen to distal essence ... nently affected organs in inborn errors of metabolism C5Recurrences in sibs, expensive fre- diarrhea when the phony substrate ...
ERC FUNDED PROJECTS | ERC: European Research Council
Liver and adipose tissue are central for regulation of glucose and lipids levels. However, during T2D the hepatic glucose ... Transplantation of human islets, isolated from cadaveric donor pancreas, potentially represents a genuine cure for TIDM but is ... Besides facilitating exciting new insights, this research can strengthen the assumption that the knowledge we have gathered ... However, the specific roles of different classes of signaling molecules in these organs remain poorly characterized. We ...
SEC Filing | Cryolife Inc.
... banks and organ procurement agencies to ensure consistent and continued availability of donated human tissue for transplant and ... As part of an effort to reduce its working capital needs, while simultaneously facilitating the use of cryopreserved tissue, ... CryoLife processes and distributes for transplantation cryopreserved human heart valves and conduits, human vascular tissue and ... Anti-Takeover Provisions The Companys Articles of Incorporation and Bylaws contain provisions that may discourage or make more ...
Pesquisa | Portal Regional da BVS
The hematopoietic transplantation program at our institution has benefited from the use of UCB as a source of transplantable ... and organ transplant rejection. The role that blood banks play in the manufacture and distribution of T-cell therapeutics is ... The provision of FMT in routine clinical practice requires an extensive infrastructure that is reliant on voluntary donors. ... The information on all aspects of cord blood banking gathered in this policy statement will facilitate parental choice for ...
Ethical aspects of genetic engineering and biotechnology | Verso un Mondo Nuovo
... "organs and tissues proper, including blood, should not be bought or sold or give rise to financial gain for the person from who ... and would be trained to perform low-grade domestic and industrial work or else provide a supply of transplantable organs ( ... cloning refers to the creation of identical embryos and tissues in order to harvest stem cells for research and transplantation ... What is more, the consequences of physical impairments can be mitigated by the provision of personal and technical support. It ...
Chronicling the Adversary's Global Takeover of the Healthcare Industry | Christ or Chaos
While organ and tissue donation agencies which operate on the CCDT guidelines, such as Ontarios Trillium Gift of Life Network ... Why not? No reason was apparent to indicate that Michaels organs would not be suitable for transplantation. Was it related to ... This enables the CCDT to hit donor increase targets by "making many more organs available sooner, and in a more transplantable ... justification for the vivisection of living human beings for their vital bodily organs so that they could be transplanted into ...
DonorsAvailable for transplantationProcurementAllogeneic transplantationRecipientsAccess to transplantationHeart transplantationKidney transplantationEngineering and regenerativeClinicalDonation after circulatory deathCellsLungShortageBoneLiver transplantUniformDistributesRecipient'sPractice1998GraftVascularCell and tissueOrganizationProcessesCentreCentersAssessGeneticallyImmunePatientsNeurologicalOversightPediatricEthicalAntigenIndicationsSuccessful organHumanPotentiallyTherapeuticCardiacTreatmentMiceConsiderationsAcceptableEfforts to increase the supplyIndividuals
- In December, the Food and Drug Administration (FDA) published the interim final rule requiring the screening and testing of tissue donors for certain transmissible diseases such as HIV and hepatitis, as well as the screening of donors for behavioral risk factors. (liveonny.org)
- In September, the FDA proposed that manufacturers of tissue-based products screen and test donors for relevant communicable diseases as safeguards to prevent the transmission of communicable diseases from infected donors. (liveonny.org)
- The American Transplant Foundation's programs provide emotional, educational, and financial support to living donors, transplant recipients, and their families across the country. (donoralliance.org)
- The Rocky Mountain Lions Eye Bank is dedicated to fulfilling the altruistic wish of their eye donors and their families and helping others in need through transplantation of donated eye tissues. (donoralliance.org)
- Both meetings agreed minimum criteria for suitability of live donors and defined the obligations of transplant professionals to treat donors as patients, including that of providing appropriate follow-up and treatment for problems caused by the donation. (who.int)
- Likewise, commercial trade in cells, tissues and organs - and even trafficking involving human beings who are kidnapped or lured into other countries where they are forced to be "donors" - continues to be a serious problem, particularly in countries with substantial transplant tourism. (who.int)
- Although DCD was the initial form of deceased organ donation, it was eclipsed by recovery of organs from individuals declared dead according to neurologic criteria after these criteria were established and evidence showed improved graft function from such donors. (aappublications.org)
- 12 The United Network for Organ Sharing has articulated Model Elements for Controlled DCD Recovery Protocols 13 and requires its member hospitals that perform solid organ transplants to develop protocols which address the required elements to facilitate the recovery of organs from donors in cases of DCD. (aappublications.org)
- all 18 hospitals provide deceased donors for solid organ transplantation. (lww.com)
- Although the procurement of organs such as livers, kidneys and lungs is permitted after either brain death or circulatory death according to Acts in all jurisdictions, the procurement of hearts has traditionally only been from brain dead donors with functioning hearts. (mja.com.au)
- Indeed, circulatory death as the source of solid organs has increased from 10% of 204 donors in 2005 to 28% of 378 donors in 2014. (mja.com.au)
- 1 , 2 More total organs have been procured (from 726 to 1193) but the number of hearts has increased only slightly from 72 of 204 donors (35%) to 79 of 378 donors (21%) over the same period. (mja.com.au)
- Conclusions The presence of an embedded SN:OD in the ED and the adoption of a collaborative care pathway to establish clinical triggers for referral to the ODT have significantly increased the rate of referral of adult potential organ donors to organ donation services. (bmj.com)
- When Policy Topic is covered Transplantation of cord blood stem cells from related or unrelated donors may be considered medically necessary in patients with an appropriate indication for allogeneic stem-cell transplant. (docplayer.net)
- Transplantation of cord blood stem cells from related or unrelated donors is considered investigational in all other situations. (docplayer.net)
Available for transplantation1
- For example, informed consent should be sought for premortem interventions to improve organ viability, and organ procurement organization personnel and members of the transplant team should not be involved in the discontinuation of life-sustaining treatment or the declaration of death. (aappublications.org)
- An amendment in law is required to permit heart procurement for transplantation after circulatory death. (mja.com.au)
- 6 , 7 Alternatively, organ procurement from patients after circulatory death may be perceived as more realisable than after brain death. (mja.com.au)
- The procurement of organs is specified in the Australian national DCD protocol published by the Organ and Tissue Authority 9 and enacted through the DonateLife network. (mja.com.au)
- Expeditious organ procurement may be commenced after death has occurred - defined in Australia as 2-5 minutes after cessation of the donor's circulation, 9 and after 2 minutes in United States. (mja.com.au)
- In the case of kidney transplantation, the extended time window may further simplify the logistics of organ transportation from the procurement site to the transplant center, and facilitate distribution of kidneys across United Network of Organ Sharing (UNOS) regions. (biomedcentral.com)
- Delays often occur at the procurement site following thoracotomy in lieu of communication with the transplant center to allow for preparation of the recipient for transplant, particularly in the case of a difficult reoperative chest. (biomedcentral.com)
- The Company seeks to expand the availability of human tissue through its established relationships with over 250 tissue banks and organ procurement agencies nationwide. (cryolife.com)
Access to transplantation6
- Findings suggest stark disparities in access to transplantation services both within and across Brazil's regions. (springer.com)
- Finally, we recommend policy strategies to reduce barriers to access to transplantation services by increasing transplantation service coverage in some areas and investing in emerging technologies. (springer.com)
- 1 We also desire to highlight that geographical factors matter: that is, patients in poorer rural areas confront transportation difficulties in obtaining access to transplantation services, which is less the case in urban areas. (springer.com)
- INTRODUCTION: Despite the availability of guidelines for the evaluation of candidates for renal transplantation, variation in access to transplantation exists. (uah.edu)
- CONCLUSIONS: There is wide variation in UK practice patterns for listing patients for renal transplantation, though its impact on access to transplantation is unclear. (uah.edu)
- The extent to which centre-specific and patient-specific factors affect access to transplantation requires further analysis in a prospective cohort of patients. (uah.edu)
- This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. (biomedcentral.com)
- Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed. (biomedcentral.com)
- Kidney transplantation in the public sector used to be a national program but has evolved into 2 separate programs operated by 2 individual AMCs. (lww.com)
- Preeclampsia and Long-term Renal Function in Women Who Underwent Kidney Transplantation. (uah.edu)
- OBJECTIVE: Preeclampsia often complicates pregnancies after maternal kidney transplantation. (uah.edu)
Engineering and regenerative2
- The advent of stem cells as a tool to decipher the cell's biology and as a source of transplant therapy to correct aging and diseases has become a core research arena for tissue engineering and regenerative medicine. (mdpi.com)
- Lung biofabrication is a new tissue engineering and regenerative development aimed at providing organs for potential use in transplantation. (ibecbarcelona.eu)
- During the 12-month period between the appointment of our SN:OD and the endpoint of our study in February 2010, a significant proportion of time has been spent in service development at trust management level as well as tutoring newly appointed SN:OD and in the continuous education of clinical staff and trust management in the importance of a successful organ donation programme within the trust. (bmj.com)
- Lung bioengineering is a disrupting concept that poses a challenge for improving our basic science knowledge and is also an opportunity for facilitating lung transplantation in future clinical translation. (ibecbarcelona.eu)
- Generation of transplantable insulin-producing cells from human embryonic stem cells or induced pluripotent stem cells is at present close to reality, and we are currently awaiting the first clinical studies. (diabetesjournals.org)
- The current indications for clinical islet transplantation are 1 ) severe unawareness of hypoglycemia and 2 ) transplantation to subjects already on systemic immunosuppression, most often because of a previous or simultaneous kidney transplant. (diabetesjournals.org)
- Currently my major focus is on clinical care of patients with liver disease and I am engaged in studies of the role of NAFLD (non-alcoholic liver disease) in patients with hepatits C and in post liver transplant patients. (stanford.edu)
Donation after circulatory death3
- The persistent mismatch between the supply of and need for transplantable organs has led to efforts to increase the supply, including controlled donation after circulatory death (DCD). (aappublications.org)
- 1 One effort to increase the supply of transplantable organs has been renewed interest in donation after circulatory death (DCD), which is the retrieval of organs from individuals declared dead after the irreversible cessation of circulatory and respiratory functions. (aappublications.org)
- In the practice of organ donation after circulatory death (DCD), life-sustaining treatment such as mechanical ventilation is commonly withdrawn because of a devastating neurological injury that has not progressed to brain death. (mja.com.au)
- The American Association of Tissue Banks (AATB) was founded to facilitate the provision of transplantable tissue and cells of uniform quality in quantities sufficient to meet national needs. (liveonny.org)
- The American Association of Tissue Banks (AATB) is a scientific, not-for-profit, peer group organization founded in 1976 to facilitate the provision of transplantable cells and tissues of uniform high quality in quantities sufficient to meet national needs. (donoralliance.org)
- Although the number of transplantations each year has grown rapidly over the past two decades, the demand for transplantation using human cells, tissues and organs has also increased significantly, resulting in a continuing shortage of human material, particularly organs. (who.int)
- As few countries are near to being self- sufficient in the provision of cells, tissues and organs for transplantation, new ways have been sought to increase the donation of human material. (who.int)
- Wharton's jelly (WJ) is a gelatinous tissue within the umbilical cord that contains myofibroblast-like stromal cells. (mdpi.com)
- Because MSCs' stemness and immune properties appear to be more robustly expressed and functional which are more comparable with fetal than adult-derived MSCs, MSCs harvested from the "young" WJ are considered much more proliferative, immunosuppressive, and even therapeutically active stem cells than those isolated from older, adult tissue sources such as the bone marrow or adipose. (mdpi.com)
- Accumulating evidence demonstrates that WJ-derived stem cells possess many potential advantages as transplantable cells for treatment of various diseases (e.g., cancer, chronic liver disease, cardiovascular diseases, nerve, cartilage and tendon injury). (mdpi.com)
- From embryogenesis initiated by a single totipotent zygote to the lifelong homeostasis of organ parenchyma by tissue‐specific stem cells, physiological differentiation of progenitor cells largely proceeds both unidirectionally and irreversibly, with differentiated cell types and even intermediate progenitors being remarkably fixed with respect to their cellular identity and functional potential. (embopress.org)
- Lung biofabrication is based on seeding cells into an acellular organ scaffold and on culturing them in an especial purpose bioreactor. (ibecbarcelona.eu)
- To avoid immune recipient's rejection of the transplanted bioengineered lung, autologous bone marrow/adipose tissue-derived mesenchymal stem cells, lung progenitor cells or induced pluripotent stem cells are used for biofabricating the bioengineered lung. (ibecbarcelona.eu)
- These physical stimuli to the organ are translated into the stem cell local microenvironment - e.g. shear stress and cyclic stretch - so that cells sense the physiological conditions in normally functioning mature lungs. (ibecbarcelona.eu)
- 1 ) provision of an unlimited source of functional human insulin-producing cells and 2 ) prevention of rejection without the side effects of systemic immunosuppression. (diabetesjournals.org)
- Encapsulation introduces a physical barrier that prevents access of immune cells to the transplanted cells but also hinders blood vessel ingrowth. (diabetesjournals.org)
- During the past decade, huge efforts have been directed toward the generation of transplantable insulin-producing cells from various stem cell sources, and recently a few reports have been published demonstrating reversal of hyperglycemia in streptozotocin-induced diabetic mice after transplantation ( 1 , 2 ). (diabetesjournals.org)
- a shortage of insulin-producing cells will only occur if we can control immune-mediated rejection of the transplanted cells without the need for systemic immunosuppression. (diabetesjournals.org)
- The focus is now on physically protecting the transplanted cells from the immune system by encapsulation ( 4 ), and large funding agencies such as JDRF have defined encapsulation as a prioritized area of research ( http://www.jdrf.org/research/ ). (diabetesjournals.org)
- More particularly, the present invention is directed to a surgical tool for transplanting retinal cells, epithelium and choroidea within their normal planar configuration, a graft for transplantation to the subretinal region of the eye, a method for preparing such grafts for transplantation, and a method for reconstructing dystrophic retinas, retinal pigment epithelial layers and choroids. (google.com)
- SynerGraft involves the depopulation of living cells from the structure of non-viable animal heart tissue and the repopulation of such tissue with human cells. (cryolife.com)
- The hematopoietic transplantation program at our institution has benefited from the use of UCB as a source of transplantable cells. (bvsalud.org)
- The survival, distribution, and phenotype of transplanted cells were assessed 6-8 months after injection. (salk.edu)
- Immunofluorescence staining and mRNA sequencing analysis demonstrated a near-complete occupation of the spinal cord by injected cells, in which transplanted human NSCs (hNSCs) preferentially acquired glial phenotypes, expressing oligodendrocyte (Olig2, APC) or astrocyte (GFAP) markers. (salk.edu)
- The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject. (patentsencyclopedia.com)
- Heart and lung transplantations are only performed at the National Heart Centre of the SDNUS while pancreas transplantation is performed at NUHS. (lww.com)
- Benign disease processes also may occlude the central airway by extrinsic compression and this may be seen in large goiters, post-pneumonectomy and post- lung transplantation stenosis and vascular malformations. (iowabeefcenter.org)
- Bioengineering of functional lung tissue by using whole lung scaffolds has been proposed as a potential alternative for patients awaiting lung transplant. (ibecbarcelona.eu)
- HRSA trains health professionals to improve systems of care in rural communities, and oversees organ, bone marrow and cord blood donation. (healthfinder.gov)
- HSB oversees the nation's organ, bone marrow and cord blood donation and transplantation systems, poison control and vaccine injury compensation programs, and a drug discount program for certain safety-net health care providers. (healthfinder.gov)
- The first bone transplantation was recorded. (liveonny.org)
- Honoring the gift of donation, AlloSource responsibly develops processes and distributes life-enhancing bone and tissue allografts for our communities. (donoralliance.org)
- Founded in 1994, AlloSource is one of the nation's largest non-profit providers of bone and soft tissue allografts for use in a host of medical treatments. (donoralliance.org)
- Its mission is to facilitate the provision of transplantable tissues of uniform high qualities sufficient to meet national needs. (healthfinder.gov)
- The LifeCenter coordinator will obtain informed, written consent for organ and/or tissue donation, from the next of kin, as per the Uniform Anatomical Gift Act. (nap.edu)
- Good Tissue Practice Final Rule - Effective May 25, the FDA finalized its proposed requirements for current good tissue practice for establishments that manufacture human cell, tissue, and cellular and tissue-based products. (liveonny.org)
- Variation in Practice Patterns for Listing Patients for Renal Transplantation in the United Kingdom: a National Survey. (uah.edu)
- In addition to the specific organ criteria, transplant candidates must also meet the following general criteria, including, but not limited to: Since compliance is a major factor in transplant graft survival, the patient (or legal guardian) must have the ability to accept and understand the transplant procedure and to maintain compliance with long-term medical management and immunosuppression. (docplayer.net)
- Renal function at conception, pregnancy outcomes, and short- and long-term graft outcomes were collected for women who were pregnant after renal transplantation and had transplant and obstetric care at the participating centers. (uah.edu)
- CONCLUSION: Preeclampsia commonly complicates pregnancies after renal transplantation but is not associated with long-term renal dysfunction or graft loss. (uah.edu)
Cell and tissue2
- The present invention relates in general to surgical instruments, surgical techniques, and cell and tissue isolation techniques. (google.com)
- It is envisaged that the development of methods enabling controlled differentiation of mouse ES cell counterparts from human blastocysts would enable the provision of an unlimited supply of tissue for cell and tissue transplantation therapies for the repair and replacement of diseased, injured, and senescent tissue. (currentprotocols.com)
- The American Association of Tissue Banks (AATB) is an educational and scientific, tax exempt organization founded in 1976. (healthfinder.gov)
- The Rocky Mountain Lions Eye Bank (RMLEB) is a community based, charitable, non-profit organization that crusades against blindness through sight restoring transplants and research into ways to overcome blindness. (donoralliance.org)
- We aim to fill in this lacuna in the literature by illustrating how regional differences in SUS human resources, medical infrastructure, waiting periods for medical attention and neurological exams lead to disparities in transplantation processes and provisions between the states. (springer.com)
- The transfer of methods such as EB formation to human systems should, by association, facilitate a more advanced understanding of similar processes associated with early human development. (currentprotocols.com)
- 1 SingHealth Transplant Centre, Singapore Health Services, Singapore. (lww.com)
- 2 National University Centre for Organ Transplantation, National University Health System, Singapore. (lww.com)
- Both AMCs have also set up multiorgan transplant centers (SingHealth Transplant at SDNUS and National University Centre for Organ Transplantation at NUHS) to integrate services across different programs while advancing academic transplantation. (lww.com)
- This national survey investigates whether centre variation exists in the assessment of patients for renal transplantation in the UK. (uah.edu)
- We assess how equity challenges within the transplantation system can be explained by wider problems within SUS. (springer.com)
- Colon tissues were collected 72 hours after TNBS administration to assess the effects of MSC treatments on the level of inflammation and damage to the ENS by immunohistochemical and histological analyses. (biomedcentral.com)
- MSCs derived from WJ display promising transplantable features, including ease of sourcing, in vitro expandability, differentiation abilities, immune-evasion and immune-regulation capacities. (mdpi.com)
- The host immune system recognizes a transplanted cell either via direct or indirect antigen presentation. (diabetesjournals.org)
- We hypothesized that a combinatorial drug formulation delivered by a poly-lactic-co-glycolic acid (PLGA) dual-sized microparticle (dMP) system would facilitate tunable drug delivery to elicit immune tolerance. (frontiersin.org)
- For over a century, immunology researchers have speculated that the immune mechanisms that are able to provide protection from pathogens, destroy transplanted allogeneic organs, or cause tissue destruction in the form of auto-immune disorders, might be directed selectively against cancer in the form of cancer immunotherapy. (biomedcentral.com)
- 25.Pierpaoli, W. and Sorkin, E. Effect of growth hormone and anti-growth hormone serum on the lymphatic tissue and the immune response. (bioclock.it)
- Their national Mentorship program offers free, one-on-one emotional support and guidance for patients and their families during their transplant journey. (donoralliance.org)
- The number of patients proceeding to organ donation increased from none to two (Fisher's exact test p=1.0). (bmj.com)
- Within this report, the introduction of embedded specialist nurses in organ donation (SN:OD) was recommended in every acute trust, and the potential role of the emergency department (ED) in the identification and referral of patients suitable for organ donation was highlighted. (bmj.com)
- Favorable outcomes after liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) are well described for patients who fall within defined tumor criteria. (stanford.edu)
- The aim of this study was to examine the response to transcatheter arterial chemoinfusion (TACI) in HCC patients awaiting LT and its efficacy for downstaging or bridging to transplantation. (stanford.edu)
- In 26% of centres transplantation was not discussed as a treatment option with all patients. (uah.edu)
- Ninety-four transplants were performed in pediatric patients and 24 in adults. (bvsalud.org)
- Engraftment was observed in 67 patients (57% of transplanted patients) and 64% of them were still alive when writing this article. (bvsalud.org)
- CONCLUSION: The IMSS UCB banking and transplantation program has had a significant impact for many IMSS patients. (bvsalud.org)
- To fulfill this mission, the AATB publishes Standards to ensure that the conduct of tissue banking meets acceptable norms of technical and ethical performance. (healthfinder.gov)
- bodies that are responding to the technical and ethical considerations raised by the various means of increasing transplantation. (who.int)
- Two central ethical issues in DCD are when organ recovery can begin and how to manage conflicts of interests. (aappublications.org)
- Victims of accidents or sudden medical traumas are declared to be "brain dead" even though this profit-making myth that was invented by a team of supposed physicians at the Harvard Medical School in 1968 in order to provide an "ethical" justification for the vivisection of living human beings for their vital bodily organs so that they could be transplanted into other human beings. (christorchaos.com)
- Specifically, we utilized 30 µm MPs to provide local sustained release of granulocyte-macrophage colony-stimulating factor (GM-CSF) and transforming growth factor β1 (TGF-β1) along with 1 µm MPs to facilitate phagocytic uptake of encapsulated antigen and 1α,25(OH) 2 Vitamin D 3 (VD3) followed by tolerogenic antigen presentation. (frontiersin.org)
- The Division of Transplantation (DoT) is within the Department of Health and Human Services, Health Resources and Services Administration's Healthcare Systems Bureau (HSB). (healthfinder.gov)
- The first completely documented human tissue grafting was performed by a Swiss surgeon, Dr. Jacques Reverdin. (liveonny.org)
- In February, the FDA proposed a new, comprehensive approach to the regulation of human cellular and tissue-based products. (liveonny.org)
- In May, the FDA proposed regulations creating a new, unified system for registering establishments that manufacture human cellular and tissue-based products and for listing their products. (liveonny.org)
- Guiding Principles on Human Organ Transplantation. (who.int)
- These Principles were the outcome of a process that began in 1987 when the Health Assembly first expressed concern, in resolution WHA40.13, about the commercial trade in human organs. (who.int)
- States to take appropriate measures to prevent the purchase and sale of human organs for transplantation (resolution WHA42.5). (who.int)
- The law defines death in all Australian jurisdictions (eg, in s 41 of the Human Tissue Act 1982 [Vic]) as either "irreversible cessation of all functions of the brain" (brain death) or as "irreversible cessation of circulation of blood in the body" (circulatory death), but it does not define irreversible or how to determine irreversibility ( Box ). (mja.com.au)
- Relatively little is known regarding the corresponding development of the early human embryo due to limitations associated with the acquisition of relevant tissue material for study. (currentprotocols.com)
- It has been shown that conventional static cold storage (SCS) techniques are incapable of providing sufficient oxygen to the core of a large (human-sized) organ, and can only oxygenate to a maximum approximate depth of a millimeter from the surface [ 9 ]. (biomedcentral.com)
- This process was initially referred to as "nonheartbeating organ donation" and then as "donation after cardiac death. (aappublications.org)
- There are many instances in which families want the opportunity to donate their loved ones organs, but do not wish to prolong the process by awaiting the onset of brain death, or cannot because criteria for formal brain death declaration might never be met prior to cardiac death. (nap.edu)
- The Rocky Mountain Division works to support the American Liver Foundation national mission to facilitate, advocate and promote education, support and resources for the prevention, treatment and cure of liver disease. (donoralliance.org)
- Controlled DCD involves organ recovery after the planned withdrawal of life-sustaining treatment and the declaration of death according to the cardiorespiratory criteria. (aappublications.org)
- 2 ) There are several forms of DCD, and the current statement focuses on "controlled" DCD: the recovery of organs after the planned withdrawal of life-sustaining medical treatment. (aappublications.org)
- To date, few studies have assessed how Brazil's universal healthcare system's (SUS, Sistema Único de Saúde) systemic, infrastructural, and geographical challenges affect individuals' abilities to access organ transplantation services and receive quality treatment. (springer.com)
- Yet, studies have paid insufficient attention to how SUS' systemic, infrastructural, and geographical challenges affect individuals' abilities to access transplantation services and receive quality treatment. (springer.com)