The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.
The region of the upper limb in animals, extending from the deltoid region to the HAND, and including the ARM; AXILLA; and SHOULDER.
The farthest or outermost projections of the body, such as the HAND and FOOT.
The inferior part of the lower extremity between the KNEE and the ANKLE.
The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)
The bones of the upper and lower ARM. They include the CLAVICLE and SCAPULA.
The superior part of the upper extremity between the SHOULDER and the ELBOW.
General or unspecified injuries involving the leg.
General or unspecified injuries involving the arm.
The bones of the upper and lower LEG. They include the PELVIC BONES.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the FEMUR; PATELLA; TIBIA; and FIBULA.
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
An alternative to amputation in patients with neoplasms, ischemia, fractures, and other limb-threatening conditions. Generally, sophisticated surgical procedures such as vascular surgery and reconstruction are used to salvage diseased limbs.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
DEEP VEIN THROMBOSIS of an upper extremity vein (e.g., AXILLARY VEIN; SUBCLAVIAN VEIN; and JUGULAR VEINS). It is associated with mechanical factors (Upper Extremity Deep Vein Thrombosis, Primary) secondary to other anatomic factors (Upper Extremity Deep Vein Thrombosis, Secondary). Symptoms may include sudden onset of pain, warmth, redness, blueness, and swelling in the arm.
Operative procedures for the treatment of vascular disorders.
The vessels carrying blood away from the capillary beds.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe or complete loss of motor function). In the older literature, paresis often referred specifically to paretic neurosyphilis (see NEUROSYPHILIS). "General paresis" and "general paralysis" may still carry that connotation. Bilateral lower extremity paresis is referred to as PARAPARESIS.
Death and putrefaction of tissue usually due to a loss of blood supply.
Neoplasm drug therapy involving an extracorporeal circuit with temporary exclusion of the tumor-bearing area from the general circulation during which high concentrations of the drug are perfused to the isolated part.
Severe or complete loss of motor function on one side of the body. This condition is usually caused by BRAIN DISEASES that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, BRAIN STEM lesions; cervical SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; and other conditions may manifest as hemiplegia. The term hemiparesis (see PARESIS) refers to mild to moderate weakness involving one side of the body.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The vein accompanying the femoral artery in the same sheath; it is a continuation of the popliteal vein and becomes the external iliac vein.
Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.
Any one of five terminal digits of the vertebrate FOOT.
The degree to which BLOOD VESSELS are not blocked or obstructed.
Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.
General or unspecified injuries to the hand.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
General or unspecified injuries involving the foot.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
The portion of the leg in humans and other animals found between the HIP and KNEE.
The vein formed by the union of the anterior and posterior tibial veins; it courses through the popliteal space and becomes the femoral vein.
A region of the lower extremity immediately surrounding and including the KNEE JOINT.
Edema due to obstruction of lymph vessels or disorders of the lymph nodes.
The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and foot. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot.
Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.
The formation or presence of a blood clot (THROMBUS) within a vein.
The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.
A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Elements of limited time intervals, contributing to particular results or situations.
Manner or style of walking.
Injuries incurred during participation in competitive or non-competitive sports.
Harmful and painful condition caused by overuse or overexertion of some part of the musculoskeletal system, often resulting from work-related physical activities. It is characterized by inflammation, pain, or dysfunction of the involved joints, bones, ligaments, and nerves.
An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.
The main artery of the thigh, a continuation of the external iliac artery.
Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.
The amount of force generated by MUSCLE CONTRACTION. Muscle strength can be measured during isometric, isotonic, or isokinetic contraction, either manually or using a device such as a MUSCLE STRENGTH DYNAMOMETER.
Radiographic visualization or recording of a vein after the injection of contrast medium.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.
Part of the body in humans and primates where the arms connect to the trunk. The shoulder has five joints; ACROMIOCLAVICULAR joint, CORACOCLAVICULAR joint, GLENOHUMERAL joint, scapulathoracic joint, and STERNOCLAVICULAR joint.
Congenital structural abnormalities of the UPPER EXTREMITY.
Radiography of blood vessels after injection of a contrast medium.
The TARSAL BONES; METATARSAL BONES; and PHALANGES OF TOES. The tarsal bones consists of seven bones: CALCANEUS; TALUS; cuboid; navicular; internal; middle; and external cuneiform bones. The five metatarsal bones are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Injuries of tissue other than bone. The concept is usually general and does not customarily refer to internal organs or viscera. It is meaningful with reference to regions or organs where soft tissue (muscle, fat, skin) should be differentiated from bones or bone tissue, as "soft tissue injuries of the hand".
Disruption of structural continuity of the body as a result of the discharge of firearms.
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Tumors or cancer located in bone tissue or specific BONES.
The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.
The region of the lower limb between the FOOT and the LEG.
Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.
Surgical shunt allowing direct passage of blood from an artery to a vein. (From Dorland, 28th ed)
A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)
Recording of the changes in electric potential of muscle by means of surface or needle electrodes.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
The vein which drains the foot and leg.
The position or attitude of the body.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.
Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with EDEMA and sometimes with VENOUS STASIS ULCERS at the ankle.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Surgical removal of an obstructing clot or foreign material which has been transported from a distant vessel by the bloodstream. Removal of a clot at its original site is called THROMBECTOMY.
Endovascular procedure in which atheromatous plaque is excised by a cutting or rotating catheter. It differs from balloon and laser angioplasty procedures which enlarge vessels by dilation but frequently do not remove much plaque. If the plaque is removed by surgical excision under general anesthesia rather than by an endovascular procedure through a catheter, it is called ENDARTERECTOMY.
The venous trunk of the upper limb; a continuation of the basilar and brachial veins running from the lower border of the teres major muscle to the outer border of the first rib where it becomes the subclavian vein.
A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)
Breaks in bones.
The continuation of the axillary vein which follows the subclavian artery and then joins the internal jugular vein to form the brachiocephalic vein.
The joint that is formed by the inferior articular and malleolar articular surfaces of the TIBIA; the malleolar articular surface of the FIBULA; and the medial malleolar, lateral malleolar, and superior surfaces of the TALUS.
Inflammation of a vein associated with a blood clot (THROMBUS).
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A vein on either side of the body which is formed by the union of the external and internal iliac veins and passes upward to join with its fellow of the opposite side to form the inferior vena cava.
Wounds caused by objects penetrating the skin.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.
The continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.
Therapeutic modalities frequently used in PHYSICAL THERAPY SPECIALTY by PHYSICAL THERAPISTS or physiotherapists to promote, maintain, or restore the physical and physiological well-being of an individual.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Congenital structural abnormalities of the LOWER EXTREMITY.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed)
The region of the upper limb between the metacarpus and the FOREARM.
A competitive nine-member team sport including softball.
A hinge joint connecting the FOREARM to the ARM.
Layers of connective tissue of variable thickness. The superficial fascia is found immediately below the skin; the deep fascia invests MUSCLES, nerves, and other organs.
Difficulty in walking from place to place.
Anatomical and functional disorders affecting the foot.
Insertion of a catheter into a peripheral artery, vein, or airway for diagnostic or therapeutic purposes.
Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.
The science of designing, building or equipping mechanical devices or artificial environments to the anthropometric, physiological, or psychological requirements of the people who will use them.
A system in which the functions of the man and the machine are interrelated and necessary for the operation of the system.
Discomfort or more intense forms of pain that are localized to the cervical region. This term generally refers to pain in the posterior or lateral regions of the neck.
Classification system for assessing impact injury severity developed and published by the American Association for Automotive Medicine. It is the system of choice for coding single injuries and is the foundation for methods assessing multiple injuries or for assessing cumulative effects of more than one injury. These include Maximum AIS (MAIS), Injury Severity Score (ISS), and Probability of Death Score (PODS).
The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.
Procedures used to reconstruct, restore, or improve defective, damaged, or missing structures.
The bones of the free part of the upper extremity including the HUMERUS; RADIUS; and ULNA.
Tongues of skin and subcutaneous tissue, sometimes including muscle, cut away from the underlying parts but often still attached at one end. They retain their own microvasculature which is also transferred to the new site. They are often used in plastic surgery for filling a defect in a neighboring region.
The joint that is formed by the distal end of the RADIUS, the articular disc of the distal radioulnar joint, and the proximal row of CARPAL BONES; (SCAPHOID BONE; LUNATE BONE; triquetral bone).
The central part of the body to which the neck and limbs are attached.
A congenital disorder that is characterized by a triad of capillary malformations (HEMANGIOMA), venous malformations (ARTERIOVENOUS FISTULA), and soft tissue or bony hypertrophy of the limb. This syndrome is caused by mutations in the VG5Q gene which encodes a strong angiogenesis stimulator.
Application of electric current in treatment without the generation of perceptible heat. It includes electric stimulation of nerves or muscles, passage of current into the body, or use of interrupted current of low intensity to raise the threshold of the skin to pain.
Prosthetic replacements for arms, legs, and parts thereof.
A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
A syndrome characterized by retropatellar or peripatellar PAIN resulting from physical and biochemical changes in the patellofemoral joint. The pain is most prominent when ascending or descending stairs, squatting, or sitting with flexed knees. There is a lack of consensus on the etiology and treatment. The syndrome is often confused with (or accompanied by) CHONDROMALACIA PATELLAE, the latter describing a pathological condition of the CARTILAGE and not a syndrome.
Force exerted when gripping or grasping.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Obstruction of flow in biological or prosthetic vascular grafts.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A neurovascular syndrome associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the superior thoracic outlet. This may result from a variety of anomalies such as a CERVICAL RIB, anomalous fascial bands, and abnormalities of the origin or insertion of the anterior or medial scalene muscles. Clinical features may include pain in the shoulder and neck region which radiates into the arm, PARESIS or PARALYSIS of brachial plexus innervated muscles, PARESTHESIA, loss of sensation, reduction of arterial pulses in the affected extremity, ISCHEMIA, and EDEMA. (Adams et al., Principles of Neurology, 6th ed, pp214-5).
The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.
The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.
Strips of elastic material used to apply pressure to body parts to control EDEMA and aid circulation.
Loss of a limb or other bodily appendage by accidental injury.
A liposarcoma containing myxomatous tissue. (Dorland, 27th ed)
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
Wooden or metal staffs designed to aid a person in walking. (UMDNS,1999)
Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.
General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.
Performance of complex motor acts.
The vessels carrying blood away from the heart.
The performance of the basic activities of self care, such as dressing, ambulation, or eating.
Mild to moderate loss of bilateral lower extremity motor function, which may be a manifestation of SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; MUSCULAR DISEASES; INTRACRANIAL HYPERTENSION; parasagittal brain lesions; and other conditions.
Diseases caused by factors involved in one's employment.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Radiographic study of the lymphatic system following injection of dye or contrast medium.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a "free interval") followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Harm or hurt to the ankle or ankle joint usually inflicted by an external source.
Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.
The projecting part on each side of the body, formed by the side of the pelvis and the top portion of the femur.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.
Penetrating wounds caused by a pointed object.
A game in which a round inflated ball is advanced by kicking or propelling with any part of the body except the hands or arms. The object of the game is to place the ball in opposite goals.
Devices for the compression of a blood vessel by application around an extremity to control the circulation and prevent the flow of blood to or from the distal area. (From Dorland, 28th ed)
A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)
An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.
Gross hypo- or aplasia of one or more long bones of one or more limbs. The concept includes amelia, hemimelia, phocomelia, and sirenomelia.
Prolonged shortening of the muscle or other soft tissue around a joint, preventing movement of the joint.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.
A POSTURE in which an ideal body mass distribution is achieved. Postural balance provides the body carriage stability and conditions for normal functions in stationary position or in movement, such as sitting, standing, or walking.
Enlarged and tortuous VEINS.
Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.
The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones.
Walking aids generally having two handgrips and four legs.
A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
Chairs mounted on wheels and designed to be propelled by the occupant.
An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
Four or five slender jointed digits in humans and primates, attached to each HAND.
A weapon designed to explode when deployed. It frequently refers to a hollow case filled with EXPLOSIVE AGENTS.
A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
Applies to movements of the forearm in turning the palm backward or downward. When referring to the foot, a combination of eversion and abduction movements in the tarsal and metatarsal joints (turning the foot up and in toward the midline of the body).
Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.
Conditions in which increased pressure within a limited space compromises the BLOOD CIRCULATION and function of tissue within that space. Some of the causes of increased pressure are TRAUMA, tight dressings, HEMORRHAGE, and exercise. Sequelae include nerve compression (NERVE COMPRESSION SYNDROMES); PARALYSIS; and ISCHEMIC CONTRACTURE.
Orthopedic appliances used to support, align, or hold parts of the body in correct position. (Dorland, 28th ed)
Injuries caused by impact with a blunt object where there is no penetration of the skin.
Equipment required for engaging in a sport (such as balls, bats, rackets, skis, skates, ropes, weights) and devices for the protection of athletes during their performance (such as masks, gloves, mouth pieces).
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)
A peripheral arterial disease that is characterized by the triad of ERYTHEMA, burning PAIN, and increased SKIN TEMPERATURE of the extremities (or red, painful extremities). Erythromelalgia may be classified as primary or idiopathic, familial or non-familial. Secondary erythromelalgia is associated with other diseases, the most common being MYELOPROLIFERATIVE DISORDERS.
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.
A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.
The application of electronic, computerized control systems to mechanical devices designed to perform human functions. Formerly restricted to industry, but nowadays applied to artificial organs controlled by bionic (bioelectronic) devices, like automated insulin pumps and other prostheses.
Surgical removal of an obstructing clot or foreign material from a blood vessel at the point of its formation. Removal of a clot arising from a distant site is called EMBOLECTOMY.
The part of a human or animal body connecting the HEAD to the rest of the body.
Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
Any method of measuring the amount of work done by an organism, usually during PHYSICAL EXERTION. Ergometry also includes measures of power. Some instruments used in these determinations include the hand crank and the bicycle ergometer.
The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.
General or unspecified injuries involving the fingers.

Novel regulation of the homeotic gene Scr associated with a crustacean leg-to-maxilliped appendage transformation. (1/3268)

Homeotic genes are known to be involved in patterning morphological structures along the antero-posterior axis of insects and vertebrates. Because of their important roles in development, changes in the function and expression patterns of homeotic genes may have played a major role in the evolution of different body plans. For example, it has been proposed that during the evolution of several crustacean lineages, changes in the expression patterns of the homeotic genes Ultrabithorax and abdominal-A have played a role in transformation of the anterior thoracic appendages into mouthparts termed maxillipeds. This homeotic-like transformation is recapitulated at the late stages of the direct embryonic development of the crustacean Porcellio scaber (Oniscidea, Isopoda). Interestingly, this morphological change is associated with apparent novelties both in the transcriptional and post-transcriptional regulation of the Porcellio scaber ortholog of the Drosophila homeotic gene, Sex combs reduced (Scr). Specifically, we find that Scr mRNA is present in the second maxillary segment and the first pair of thoracic legs (T1) in early embryos, whereas protein accumulates only in the second maxillae. In later stages, however, high levels of SCR appear in the T1 legs, which correlates temporally with the transformation of these appendages into maxillipeds. Our observations provide further insight into the process of the homeotic leg-to-maxilliped transformation in the evolution of crustaceans and suggest a novel regulatory mechanism for this process in this group of arthropods.  (+info)

Mechanisms of GDF-5 action during skeletal development. (2/3268)

Mutations in GDF-5, a member of the TGF-beta superfamily, result in the autosomal recessive syndromes brachypod (bp) in mice and Hunter-Thompson and Grebe-type chondrodysplasias in humans. These syndromes are all characterised by the shortening of the appendicular skeleton and loss or abnormal development of some joints. To investigate how GDF-5 controls skeletogenesis, we overexpressed GDF-5 during chick limb development using the retrovirus, RCASBP. This resulted in up to a 37.5% increase in length of the skeletal elements, which was predominantly due to an increase in the number of chondrocytes. By injecting virus at different stages of development, we show that GDF-5 can increase both the size of the early cartilage condensation and the later developing skeletal element. Using in vitro micromass cultures as a model system to study the early steps of chondrogenesis, we show that GDF-5 increases chondrogenesis in a dose-dependent manner. We did not detect changes in proliferation. However, cell suspension cultures showed that GDF-5 might act at these stages by increasing cell adhesion, a critical determinant of early chondrogenesis. In contrast, pulse labelling experiments of GDF-5-infected limbs showed that at later stages of skeletal development GDF-5 can increase proliferation of chondrocytes. Thus, here we show two mechanisms of how GDF-5 may control different stages of skeletogenesis. Finally, our data show that levels of GDF-5 expression/activity are important in controlling the size of skeletal elements and provides a possible explanation for the variation in the severity of skeletal defects resulting from mutations in GDF-5.  (+info)

Regulation of neurotrophin-3 expression by epithelial-mesenchymal interactions: the role of Wnt factors. (3/3268)

Neurotrophins regulate survival, axonal growth, and target innervation of sensory and other neurons. Neurotrophin-3 (NT-3) is expressed specifically in cells adjacent to extending axons of dorsal root ganglia neurons, and its absence results in loss of most of these neurons before their axons reach their targets. However, axons are not required for NT-3 expression in limbs; instead, local signals from ectoderm induce NT-3 expression in adjacent mesenchyme. Wnt factors expressed in limb ectoderm induce NT-3 in the underlying mesenchyme. Thus, epithelial-mesenchymal interactions mediated by Wnt factors control NT-3 expression and may regulate axonal growth and guidance.  (+info)

Fibrocartilage in tendons and ligaments--an adaptation to compressive load. (4/3268)

Where tendons and ligaments are subject to compression, they are frequently fibrocartilaginous. This occurs at 2 principal sites: where tendons (and sometimes ligaments) wrap around bony or fibrous pulleys, and in the region where they attach to bone, i.e. at their entheses. Wrap-around tendons are most characteristic of the limbs and are commonly wider at their point of bony contact so that the pressure is reduced. The most fibrocartilaginous tendons are heavily loaded and permanently bent around their pulleys. There is often pronounced interweaving of collagen fibres that prevents the tendons from splaying apart under compression. The fibrocartilage can be located within fascicles, or in endo- or epitenon (where it may protect blood vessels from compression or allow fascicles to slide). Fibrocartilage cells are commonly packed with intermediate filaments which could be involved in transducing mechanical load. The ECM often contains aggrecan which allows the tendon to imbibe water and withstand compression. Type II collagen may also be present, particularly in tendons that are heavily loaded. Fibrocartilage is a dynamic tissue that disappears when the tendons are rerouted surgically and can be maintained in vitro when discs of tendon are compressed. Finite element analyses provide a good correlation between its distribution and levels of compressive stress, but at some locations fibrocartilage is a sign of pathology. Enthesis fibrocartilage is most typical of tendons or ligaments that attach to the epiphyses of long bones where it may also be accompanied by sesamoid and periosteal fibrocartilages. It is characteristic of sites where the angle of attachment changes throughout the range of joint movement and it reduces wear and tear by dissipating stress concentration at the bony interface. There is a good correlation between the distribution of fibrocartilage within an enthesis and the levels of compressive stress. The complex interlocking between calcified fibrocartilage and bone contributes to the mechanical strength of the enthesis and cartilage-like molecules (e.g. aggrecan and type II collagen) in the ECM contribute to its ability to withstand compression. Pathological changes are common and are known as enthesopathies.  (+info)

gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limb. (5/3268)

The growth-arrest-specific 2 (gas2) gene was initially identified on account of its high level of expression in murine fibroblasts under growth arrest conditions, followed by downregulation upon reentry into the cell cycle (Schneider et al., Cell 54, 787-793, 1988). In this study, the expression patterns of the gas2 gene and the Gas2 peptide were established in the developing limbs of 11.5- to 14. 5-day mouse embryos. It was found that gas2 was expressed in the interdigital tissues, the chondrogenic regions, and the myogenic regions. Low-density limb culture and Brdu incorporation assays revealed that gas2 might play an important role in regulating chondrocyte proliferation and differentiation. Moreover, it might play a similar role during limb myogenesis. In addition to chondrogenesis and myogeneis, gas2 is involved in the execution of the apoptotic program in hindlimb interdigital tissues-by acting as a death substrate for caspase enzymes. TUNEL analysis demonstrated that the interdigital tissues underwent apoptosis between 13.5 and 15.5 days. Exactly at these time points, the C-terminal domain of the Gas2 peptide was cleaved as revealed by Western blot analysis. Moreover, pro-caspase-3 (an enzyme that can process Gas2) was cleaved into its active form in the interdigital tissues. The addition of zVAD-fmk, a caspase enzyme inhibitor, to 12.5-day-old hindlimbs maintained in organ culture revealed that the treatment inhibited interdigital cell death. This inhibition correlated with the absence of the Gas2 peptide and pro-caspase-3 cleavage. The data suggest that Gas2 might be involved in the execution of the apoptotic process.  (+info)

Conservation of the expression and function of apterous orthologs in Drosophila and mammals. (6/3268)

The Drosophila apterous (ap) gene encodes a protein of the LIM-homeodomain family. Many transcription factors of this class have been conserved during evolution; however, the functional significance of their structural conservation is generally not known. ap is best known for its fundamental role as a dorsal selector gene required for patterning and growth of the wing, but it also has other important functions required for neuronal fasciculation, fertility, and normal viability. We isolated mouse (mLhx2) and human (hLhx2) ap orthologs, and we used transgenic animals and rescue assays to investigate the conservation of the Ap protein during evolution. We found that the human protein LHX2 is able to regulate correctly ap target genes in the fly, causes the same phenotypes as Ap when ectopically produced, and most importantly rescues ap mutant phenotypes as efficiently as the fly protein. In addition, we found striking similarities in the expression patterns of the Drosophila and murine genes. Both mLhx2 and ap are expressed in the respective nerve cords, eyes, olfactory organs, brain, and limbs. These results demonstrate the conservation of Ap protein function across phyla and argue that aspects of its expression pattern have also been conserved from a common ancestor of insects and vertebrates.  (+info)

Respecified larval proleg and body wall muscles circulate hemolymph in developing wings of Manduca sexta pupae. (7/3268)

Most larval external muscles in Manduca sexta degenerate at pupation, with the exception of the accessory planta retractor muscles (APRMs) in proleg-bearing abdominal segment 3 and their homologs in non-proleg-bearing abdominal segment 2. In pupae, these APRMs exhibit a rhythmic 'pupal motor pattern' in which all four muscles contract synchronously at approximately 4 s intervals for long bouts, without externally visible movements. On the basis of indirect evidence, it was proposed previously that APRM contractions during the pupal motor pattern circulate hemolymph in the developing wings and legs. This hypothesis was tested in the present study by making simultaneous electromyographic recordings of APRM activity and contact thermographic recordings of hemolymph flow in pupal wings. APRM contractions and hemolymph flow were strictly correlated during the pupal motor pattern. The proposed circulatory mechanism was further supported by the findings that unilateral ablation of APRMs or mechanical uncoupling of the wings from the abdomen essentially abolished wing hemolymph flow on the manipulated side of the body. Rhythmic contractions of intersegmental muscles, which sometimes accompany the pupal motor pattern, had a negligible effect on hemolymph flow. The conversion of larval proleg and body wall muscles to a circulatory function in pupae represents a particularly dramatic example of functional respecification during metamorphosis.  (+info)

Chick Barx2b, a marker for myogenic cells also expressed in branchial arches and neural structures. (8/3268)

We have isolated a new chicken gene, cBarx2b, which is related to mBarx2 in sequence, although the expression patterns of the two genes are quite different from one another. The cBarx2b gene is expressed in craniofacial structures, regions of the neural tube, and muscle groups in the limb, neck and cloaca. Perturbation of anterior muscle pattern by application of Sonic Hedgehog protein results in a posteriorization of cBarx2b expression.  (+info)

DURING vertebrate limb development, positional information must be specified along three distinct axes. Although much progress has been made in our understanding of the molecular interactions involved in anterior-posterior and proximal-distal limb patterning, less is known about dorsal-ventral patterning1-3. The genes Wnt-7a and Lmx-1, which are expressed in dorsal limb ectoderm and mesqderm, respectively, are thought to be important regulators of dorsal limb differentiation4-6. Whether a complementary set of molecules controls ventral limb development has not been clear. Here we report that Engrailed-1, a homeodomain-containing transcription factor expressed in embryonic ventral limb ectoderm7-8, is essential for ventral limb patterning. Loss of Engrailed-1 function in mice results in dorsal transformations of ventral paw structures, and in subtle alterations along the proximal-distal limb axis. Engrailed-1 seems to act in part by repressing dorsal differentiation induced by Wnt-7a, and is essential
TY - JOUR. T1 - Trophic effect of transferrin on amphibian limb regeneration blastemas. AU - Mescher, Anthony. AU - Munaim, S. I.. PY - 1984. Y1 - 1984. UR - UR - M3 - Article. VL - 230. SP - 485. EP - 490. JO - Journal of Experimental Zoology Part A: Comparative Experimental Biology. JF - Journal of Experimental Zoology Part A: Comparative Experimental Biology. SN - 0022-104X. IS - 3. ER - ...
A method and apparatus for anchoring suture to bone includes an anchor formed by twisting a wire to provide a loop with two legs extending distally from the twist. Each leg bends outwardly through 180 to define respective knee segments between inner and outer leg segments, the outer leg segments terminating in sharp points for penetrating a bone tunnel wall. The outer leg segments are initially parallel and define an anchor width smaller than the bone tunnel diameter, thereby permitting the anchor to be inserted into and removed from the tunnel. The anchor is deployed with an insertion tool arranged to deformably pivot the outer leg segments about the knee segments, thereby causing the pointed ends to penetrate the tunnel wall in response to applied withdrawal forces. The anchor wire may be assembled on an anchor sleeve through which the loop projects proximally while the outer leg segments reside in wire relief recesses defined in the sleeve periphery. The insertion tool selectively forces the sleeve
TY - JOUR. T1 - Differential expression of the frizzled family involved in Wnt signaling during chick limb development.. AU - Nohno, T.. AU - Kawakami, Y.. AU - Wada, N.. AU - Komaguchi, C.. AU - Nishimatsu, S.. PY - 1999/7. Y1 - 1999/7. N2 - Members of the frizzled (Fz) family are involved in Wnt signaling during embryogenesis in the vertebrate. We identified chicken cognates of Fz-2, Fz-3, Fz-4, Fz-6 and Fz-8, and examined spatial and temporal expression patterns in the chick embryos by whole-mount in situ hybridization. Fz-4 is intensely expressed in the apical ectodermal ridge and distal mesenchyme of the limb bud at stages 20 to 27. The transcripts are confined to the posterior-distal end of the digit-forming region at stages 25 to 27. Fz-2 is weakly expressed in the proximal limb mesenchyme at stages 25 to 27, while Fz-3 and Fz-6 expressions are uniform in the limb bud at these stages. Fz-2 is also expressed in the dermatomyotome. No expression signal for Fz-8 is detectable in the embryo ...
To investigate whether the uniqueness of proximal and distal limb regenerates could be attributed simply to differing blastemal growth characteristics, their increase in volume, cell number and cell-cycle times were determined. With respect to these parameters proximal and distal blastemas were identical and, furthermore, no evidence could be found for the existence of separate growth zones such as an apical proliferation centre or a progress zone within the blastema. It was therefore concluded that level-specific properties of the blastemal cells play the major role in determining the structure of the regenerate, not their growth characteristics. The only discernible difference was in the cell number within the two types of blastema at the onset of cartilage redifferentiation- proximal regenerates had 60 % more cells. Thus it seems that the larger the pattern to be regenerated (the more proximal the amputation plane), the larger the primordium within which that pattern first appears. These two ...
Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control?
An extraction device comprising a sheath, distal legs that project from the sheath, and actuating means for retracting the legs into the sheath and deploying the distal legs from the sheath. The distal legs are formed to have a parabolic curved shape, such that the distal legs automatically deploy radially outward and away from each other when deployed outside the sheath with the actuating means. As such, a plunger is not required to operate the legs. When retracted into the sheath with the actuating means, the distal legs elastically deform, collapsing radially toward each other to acquire a mid-deployed position in which the legs define a basket. The legs can be further retracted into the sheath, providing a stowed position in which the legs are substantially parallel to each other. Each of the distal legs has a concave cross-section that contributes greater strength to the legs, such that they maintain their form and alignment and provide greater grasping strength and expansion force than extraction
Major advances in the genetics of vertebrate limb development have been obtained in recent years. However, the nature of the signals which trigger differentiation of the mesoderm to form the limb skeleton remains elusive. Previously, we have obtained evidence for a role of TGFbeta2 in digit formation. Here, we show that activins A and B and/or AB are also signals involved in digit skeletogenesis. activin betaA gene expression correlates with the initiation of digit chondrogenesis while activin betaB is expressed coincidently with the formation of the last phalanx of each digit. Exogenous administration of activins A, B or AB into the interdigital regions induces the formation of extra digits. follistatin, a natural antagonist of activins, is expressed, under the control of activin, peripherally to the digit chondrogenic aggregates marking the prospective tendinous blastemas. Exogenous application of follistatin blocks physiological and activin-induced digit formation. Evidence for a close ...
Homeobox-containing genes are thought to be involved in the regulation of pattern formation and specification of positional information during vertebrate limb development. Because of its accessibility to microsurgical manipulation, the developing chick limb bud provides a powerful system for investi …
A device compressing a flexible elongate member having proximal and distal extremities and having a plurality of circumferentially spaced-apart elements having a characteristic disposed in the distal
Manson, J.M. and Smith, C.C. (1977) Influence of Cyclophosphamide and 4-Ketocyclophosphamide on Mouse Limb Development. Teratology, 15, 291-299.
The development of a vertebrate embryo is a complex process marked by several morphogenetic events, which create a highly reproducible pattern. The vertebrate limb has emerged as a model for studying pattern formation in the embryo mainly because limb manipulations do not affect embryo survival. Within the developing limb, experimental manipulation of the embryo resulted in the identification of the classical signaling centers known as the Zone of Polarizing Activity (ZPA) and the Apical Ectodermal Ridge (AER). The molecular signals required for function of the ZPA and AER have been identified. They are Sonic hedgehog (Shh) from the ZPA and Fibroblast Growth Factors (Fgfs) from the AER. The functions of each of these molecules are now beginning to be understood. Analysis of Shh and hedgehog (Hh) signaling target genes has shown that Hh activation in the limb bud mesoderm is required for normal limb development. It has been stated that Hh signaling in the limb bud ectoderm cannot occur because ...
Although, the requirement for multiple inputs into gene regulation is typical in transcriptional regulation, for most cases where multiple positive inputs are required, the underlying mechanism is not well understood (reviewed by Arnosti, 2003; Barolo and Posakony, 2002; Guss et al., 2001; Mann and Carroll, 2002; Merika and Thanos, 2001). By contrast, there are many examples of genes that integrate both positive and negative inputs to be activated in a spatially or temporally restricted manner(Arnosti, 2003). The enhancers mediating this control can be thought of as `logic integrators that are active only in the presence of the correct activators and in the absence of repressors (Istrail and Davidson,2005). We suggest that such a mechanism can account for why Dpp and Wg are both required for the activation of Dll and dacduring leg development. Although both pathways are required for activating these genes, our finding that Dpp functions by repressing a repressor creates a situation in which ...
Goggin JM, Hoskinson JJ, Carpenter JW, et al. Vet Radiol Ultrasound 1997;38:211-220. To assess the role of scintigraphic evaluation of distal limb perfusion,
Our data confirm that the timing mechanism does not rely on the integration of FGF signaling over time (Fig. 4), something that was previously suggested by the inability of excess FGF to activate Hoxa13 prematurely (Fig. 3) (Vargesson et al., 2001). Importantly, this does not mean that FGF signaling is not necessary for Hoxa13 expression during normal limb development. Indeed, we show that FGF signaling is needed to keep RA signaling away from the distal region, but that its role is merely permissive and not instructive: if RA signaling is artificially blocked from the distal region, the timing mechanism can proceed in the absence of FGF signaling (Fig. 4).. The alternative mechanism that we explored concerns chromatin state. It has been proposed that regulation of HoxD expression differs considerably between the limb [two transcriptional waves dependent on the interaction of Hox loci with distinct topological domains (Andrey et al., 2013; Montavon et al., 2011)] and the tail bud [strict ...
The upper and lower limbs (including the shoulder and pelvic girdles) begin development in the 4th week of gestation. Their embryological development is of great clinical and anatomical importance.
Our group focuses on the study of the cellular and molecular mechanisms controlling limb development and fin regeneration. We are trying to understand how the main signalling centre in limb development, the Apical Ectodermal Ridge (AER), is established and maintained through development and how different molecules, namely those related to stemness, are involved in these processes. Also, we have developed a line of research directed to depict how ion dynamics can control limb development, digit differentiation and fin regeneration. In these studies we use the chicken and zebrafish embryos as well as adult zebrafish as animal models.. ...
The present invention relates to a steerable catheter (21) comprising a flexible elongate tubular member (22) having proximal (23) and distal (24) extremities, a handle (27) secured to the proximal extremity (23), said tubular member (22) having a lumen (31-37) extending therethrough, a mandrel (41,42,43) slidably mounted in the lumen (31-37) and extending into the distal extremity (24) and means (56) extending through the tubular member (22) for causing a bending of the distal extremity (24) with respect to the mandrel (41,42,43) disposed therein.
A large-diameter expandable sheath for use in introducing a catheter or other medical instrument into a vessel in the body of a patient. The expandable sheath comprises an elongate sheath tube formed of a flexible material which has proximal and distal extremities and a passage extending therethrough of a maximum predetermined diameter. The distal extremity of the elongate sheath tube is folded longitudinally to a smaller folded diameter. The sheath tube may be self-expanding or may be reinforced with a self-expanding wire or expandable stents. A backflow adapter is secured to the proximal extremity of the elongate sheath tube. The backflow adapter has a central opening therein in registration with the passage in the sheath tube. A normally closed primary valve is disposed in the central opening of the backflow adapter and is movable to an open position. A normally open secondary valve, movable to a closed position, may be configured in the backflow adapter proximal the sheath tube and distal the
The mapping and/or ablation catheter for use in ablating the tissue in the wall forming a chamber in the heart comprising a flexible elongate tubular member having proximal and distal extremities, end cap formed of a conductive material mounted on the distal extremity of the flexible elongate tubular member, a fixation means carried by the end cap for engaging the wall of the heart and for retaining the end cap in a predetermined position on the wall of the heart during beating of the heart, said fixation means being movable between tissue engaging and disengaging positions. The means carried by the proximal extremity of the flexible elongate tubular member for moving the fixation means between the engaging and disengaging positions.
2017, Northcentral University, Murats review: Lasix 100 mg, 40 mg. Trusted online Lasix... On examination, her temperature is F (C), her respiratory rate is breaths/min, and rhonchi are noted in both lung fields. When VZV vasculopathydevelops months after zoster, antiviral treatment is often effective. Findings on plain film (such as the colon cutoff sign; enhance-ment of perirenal fat caused by retroperitoneal inflammation that creates a halo aroundthe left kidney; or an abnormal duodenal loop) can suggest the diagnosis of pancreatitisbut do not reveal its cause. A ratio of pleural lactate dehydrogenase (LDH) to serum LDHgreater than C. Definitive diagnosis depends on radiographic detection of a mass lesion; treat-ment with drainage may be indicated. As the patient sits in the clinic chair, her distal extremities are seen to be a deep red, andthe skin of the distal extremities is smooth and thin, without hair. Structurally, however, plexiform bone resembles highly oriented cancellous bone. ...
Apparatus for cleaning a vessel having a stenosis therein comprising first and second balloon catheters. Balloons are disposed on opposite sides of the stenosis in the vessel and form a closed chamber in the vessel. A therapeutic catheter having a distal extremity is disposed in the chamber. Irrigation liquid is supplied to the chamber and liquid is aspirated from the chamber to form an aspirate. The distal extremity of the therapeutic catheter is moved to cause the material forming the stenosis to be removed from the wall of the vessel and to be broken into particles which are removed with the aspirate.
Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JT, Wong MD, Li D, Deimling S, Ciruna B, Scott I, Simmons C, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. Nat Cell Biol. 2015 May; 17(5):569-79 ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
There is no obvious morphological counterpart of the autopod (wrist/ankle and digits) in living fishes. Comparative molecular data may provide insight into understanding both the homology of elements and the evolutionary developmental mechanisms behind the fin to limb transition. In mouse limbs the autopod is built by a late phase of Hoxd and Hoxa gene expression, orchestrated by a set of enhancers located at the 5 end of each cluster. Despite a detailed mechanistic understanding of mouse limb development, interpretation of Hox expression patterns and their regulation in fish has spawned multiple hypotheses as to the origin and function of autopod enhancers throughout evolution. Using phylogenetic footprinting, epigenetic profiling, and transgenic reporters, we have identified and functionally characterized hoxD and hoxA enhancers in the genomes of zebrafish and the spotted gar, Lepisosteus oculatus, a fish lacking the whole genome duplication of teleosts. Gar and zebrafish autopod ...
Since I still dont understand your point, let me just say this: When scientists interpret the pentadactyl limb as homologous across tetrapods, they assume that changing the basic structure of the limb bones is more difficult than simply altering their relative proportions. Some scientists may also surmise that a creator is free to modify his (its) designs to maximise their usefulness, so wed expect substantially different limb structures across creatures in different environments. This evidence is indeed entangled in background assumptions. Yet look where this leads: given the above, the pentadactyl limb suggests a common ancestor for tetrapods under evolutionary theory. The theory then predicts that other measures of relatedness will group tetrapods together relative to other creatures. So look at the pentadactyl limb as a prediction, with subsequent analyses verifying that prediction. Now its true that you cant use the same evidence to generate and test a hypothesis, so under this ...
tuning would apply to more complex future models. In terms of the physiological simplifications, the interactions among F-V and F-L effects are potentially confounding given that large length changes reduce the optimal V/Vmax for producing power [43]. However, recent work demonstrates that muscle contractions beginning at longer starting lengths (stretched slightly beyond optimal length) enable the muscle to reach the plateau of the F-L curve at the time of maximum muscle activation [22]. Thus, at the time point of peak activation and muscle power, F-L effects would not influence maximum muscle power for the current model. Indeed, our in silico-robotic experiments, which do include F-L effects, match well with our simple model predictions (figure 6).. Secondly, experiments were performed in still water without translational motion of the foot. In a simple rower (figure 2d), oar blades would have an aft-directed rotational and translational component as they rotate about their base. Therefore, in ...
Distal Tibia, Proximal and Distal Radius, Carpus and Tarsus partial arthrodesis, Pelvis, Femur, Tibia, Pelvis Distal Extremity, Humerus, Radius/ ...
Published in Nature Communications, the study paves the way to research into the function of this pathway in vertebrate development and its possible involvement in human congenital diseases.
Fearful frustrated parents deliver their ill appearing 17-year-old daughter to your office for evaluation of persistent painful papules and plaques associated with high fever, sore throat, and arthralgias (fig1, 2, 3). The eruption first appeared on the distal extremities 3 days ago and has now disseminated to the proximal extremities and trunk. She was sent home from the local emergency room yesterday with instructions to take plenty of fluids and ibuprofen ...
Introduction:Acute discoloration and paresthesia of a distal extremity is concerning for an ischemic event or a manifestation of underlying systemic disease. Achenbach syndrome is an infrequent, but benign etiology of an acute blue finger that needs to be recognized clinically. We present a case to increase awareness. Case:A 57-year-old Caucasian female presented to rheumatology clinic for bruising digits.
An endocardial catheter for mapping and/or ablation for use in a chamber of a heart defined by a wall comprising a flexible elongate tubular member having proximal and distal extremities. A basket ass
(2001) BMP controls proximodistal outgrowth, prescritpion induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. Titrate with 0.
Where two or more injections are required at once, these should ideally be given in different limbs. Where this is not possible, injections in the same limb should be given 2.5cm apart. ...
Kid-sized for shredding singletrack, the Boys Hotrock 24 XC comes equipped with everything your little ripper needs to start riding with the big kids. It features a lightweight, yet durable, A1 Premium aluminium frame thats designed to take a hit while they find their legs on the pump track, while chatter and bumps are handled by the coil-sprung SR Suntour forks 50mm of travel. Then there are a whole host of other components that are plenty tough enough to stand up to your little one, so you can rest assured that youll be spending more time riding with your kid then waiting in line at the repair counter.
The purpose of this study was to examine how the limb segment inertial parameters vary across the decades from the 1920s to the 1970s. Sixty-six males participated in this study, ranging in age from 20 to 79 years ...
Even if you feed your dog properly, treat it well, make sure it is active, and demonstrate great prudence, it can still get sick or wounded. You will mostly find out about that only after you realize that your dog is behaving abnormally. Injuries could be anywhere in the body, but most often the limbs are involved ...
New Components of Drosophila Leg Development Identified through Genome Wide Association Studies. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Montgomery EA, Devaney KO, Giordano TJ, Weiss SW. Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkins disease, and various sarcomas. Mod Pathol 1998 Apr;11(4):384-91 ...
TY - JOUR. T1 - Rdh10 mutants deficient in limb field retinoic acid signaling exhibit normal limb patterning but display interdigital webbing. AU - Cunningham, Thomas J.. AU - Chatzi, Christina. AU - Sandell, Lisa L.. AU - Trainor, Paul A.. AU - Duester, Gregg. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2011/5. Y1 - 2011/5. N2 - Retinoic acid (RA) is purported to be required for expression of genes controlling proximodistal (Meis2) or anteroposterior (Shh) limb patterning. Embryos lacking RDH10, the primary enzyme synthesizing retinaldehyde during mouse development, survive until E14.5 with stunted forelimbs but apparently normal hindlimbs. Using embryos carrying the RARE-lacZ RA-reporter transgene, we show that endogenous RA activity in Rdh10trex/trex mutants is detected in neuroectoderm but not limbs during initiation and patterning. Treatment of Rdh10 mutants with 25 nM RA restores RARE-lacZ activity to limb mesoderm, validating RARE-lacZ and verifying that RA is ...
TY - JOUR. T1 - The expression of Fat-1 cadherin during chick limb development. AU - Terence , Smith. AU - Hateren, Nick Van AU - Tickle, Cheryll. AU - Wilson, Stuart PY - 2007. Y1 - 2007. N2 - Cellular adhesion is fundamental to the behaviour of cell populations during embryonic development and serves to establish correct tissue pattern and architecture. The cadherin superfamily of cell adhesion proteins regulates cellular organization and additionally influences intracellular signalling cascades. Here we present for the first time a detailed account of chick Fat-1 gene expression during embryogenesis visualised by whole-mount in situ hybridisation. In part, we focus on the expression pattern in limb buds that has not been accurately documented. While Fat-1 is generally expressed in epithelial tissues and its Drosophila counterpart Fat-like regulates formation of ectodermally-derived organs, in limb buds we have found that chick Fat-1 is uniquely restricted to mesenchyme. This Fat-1 expression ...
An abundance of data across several vertebrate taxon groups (3, 11, 12) suggests that nerves may have a conserved evolutionary role that is essential to, or permissive for, limb regeneration. Despite the absence of innervation to the hind limb throughout the time of regeneration, the mouse model replaces the amputated digit tip with surprising fidelity in most tissue types. Our comprehensive examination at single-cell levels of primary hind limb tissues during normal maintenance, regeneration, and wound healing reveals that many presumed tissue stem/progenitor cells maintain clonal and differentiation capabilities in the absence of nerve supply.. In salamander embryos, removal of a large section of the neural tube leads to limb development without innervation. These limbs can be transplanted to the flank of a normal larva, where they can regenerate in the absence of nerve supply (33). This lack of nerve dependence is made possible by the substitution of nerve-derived factors from ectodermal ...
A new study has provided more insight into the effortless manner in which insects like mosquitoes and water striders are able to walk on water. The secret seems
Considerable evidence exists to support the hypothesis that mechanical forces have an essential role in healthy embryonic skeletal development. Clinical observations and experimental data indicate the importance of muscle contractions for limb development. However, the influence of these forces is seldom referred to in biological descriptions of bone development, and perhaps this is due to the fact that the hypothesis that mechanical forces are essential for normal embryonic skeletal development is difficult to test and elaborate experimentally in vivo, particularly in humans. Computational modeling has the potential to address this issue by simulating embryonic growth under a range of loading conditions but the potential of such models has yet to be fully exploited. In this article, we review the literature on mechanobiology of limb development in three main sections: (a) experimental alteration of the mechanical environment, (b) mechanical properties of embryonic tissues, and (c) the use of ...
Steerable balloon dilatation catheter assembly having dye injection and pressure measurement capabilities and comprising an elongate flexible tubular member having first and second lumens extending therethrough and a balloon carried by the distal portion of the tubular member and having its interior in communication with the second lumen. A guide wire extends through the first lumen and has a coil carried by the distal portion thereof and extending beyond the distal extremity of the tubular member. A device is coupled to the guide wire facilitating at least limited rotation of the distal extremity of the guide wire. A first fitting is coupled to the second lumen and is adapted to receive a liquid for inflating and deflating the balloon. A second fitting is in communication with the first lumen. The first lumen and the guide wire being sized so that dye injections and/or pressure measurements can be made through the second fitting.
Fig. (9) Reported sensations across all trials on all nerves. The low frequency pulse train resulted in the most non-paresthesia sensations with minimal discomfort. Some totals are over 100% since some subjects reported more than one descriptor per trial. Sensations that were reported fewer than three times are not included in this figure. ...
Objective: To evaluate the outcome of treatment of antebrachial and crural septic non-union fractures in dogs using circular external skeletal fixation (CESF), and to document the type and frequency of complications associated with this technique. Methods: The medical records of all dogs with infected antebrachial and crural non-union fractures treated using the methods of Ilizarov at the Department of Animal Pathology of the University of Turin between 2006 and 2011 were retrospectively reviewed. ...
Arthrex Inc. seeks creative, resourceful and technically knowledgeable professionals to join our team The Medical Education team is looking for an M.D., Physician Assistant or Nurse Practitioner for their open Clinical Specialist position. Experience in orthopaedics, arthroscopy and trauma preferred. This is not a sales role, but a corporate medical education position teaching our surgeons and Technology Consultants on our products in our surgical skills lab. This is a unique opportunity to utilize your surgical experience in the industry. Never take a call or wear a pager again! We pay 100% of medical and dental premiums for employees and 50% for dependent coverage; free lunch; gym membership; matching 401k; etc. We will assist you with relocation. As one of the 2015 and 2016 FORTUNE
For any non-gliding animal, the distance of a leap depends on the direction and magnitude of its velocity vector at take-off. For a standing-start leap, the velocity achieved by the animal is limited by the amount of energy imparted to the body before take-off. This, in turn, is limited by the ability of the muscles to perform mechanical work on the body.. Specialized leapers demonstrate a number of adaptations that increase both the force applied to the substrate (e.g. the power-amplifying mechanisms of galagos [1], froghoppers [2], fleas [3] and locusts [4]), and the distance over which force is applied (e.g. the elongated distal leg segments of galagos [5] and frogs [6], the manipulation of the force-length characteristics of anuran leg muscle [7]). Adaptations such as these are synonymous with maximizing mechanical work and improving leap performance.. Behavioural strategies during the push-off and landing phases can significantly increase the mechanical work performed and lengthen the leap ...
The HoxD cluster is critical for vertebrate limb development. Enhancers located in both the telomeric and centromeric gene deserts flanking the cluster regulate the transcription of HoxD genes. In rare patients, duplications, balanced translocations or inversions misregulating HOXD genes are responsible for mesomelic dysplasia of the upper and lower limbs. By aCGH, whole-genome mate-pair sequencing, long-range PCR and fiber fluorescent in situ hybridization, we studied patients from two families displaying mesomelic dysplasia limited to the upper limbs. We identified microduplications including the HOXD cluster and showed that microduplications were in an inverted orientation and inserted between the HOXD cluster and the telomeric enhancers. Our results highlight the existence of an autosomal dominant condition consisting of isolated ulnar dysplasia caused by microduplications inserted between the HOXD cluster and the telomeric enhancers. The duplications likely disconnect the HOXD9 to HOXD11 genes from
The lab of Craig Crews, Ph.D., Department of Molecular, Cellular and Developmental Biology at Yale is inviting applications for multiple postdoctoral positions. With an emphasis on regenerative medicine, the lab investigates the inductive role of the wound epidermis on cellular dedifferentiation during amphibian limb regeneration.. Our research has recently revealed key genes that are specifically expressed in the regenerating epidermis of the Mexican salamander (aka, the Axolotl). Several of these genes encode secreted or membrane-bound proteins that may play a role in inducing/maintaining the dedifferentiated state of the underlying mesenchyme during regeneration and thus may serve as a natural analogy for the induction of iPS cells. We are exploring the roles of these proteins using both cell culture-based assays and in vivo/transgenic expression analyses. These projects are partly supported by the NIH and the Ellison Medical Foundation.. A successful candidate should be self-motivated with a ...
We have recently identified Dlkl/FA1 as a novel surface marker for chondroprogenitor cells during embryonic chondrogenesis and demonstrated the Akt pathway-dependent inhibition of insulin induced in vitro chondrogenesis by Dlk1/FA1 [21, 22]. However, the mechanisms by which Dlk1 is regulated and its interaction with other signaling pathways during chondrogenic differentiation are not well known. In this study, we have identified Dlk1 as a novel downstream target of the TGF-β signaling pathway that mediates its function by promoting early chondrogenesis. Additionally, we observed altered Smad2 phosphorylation with Dlk1/FA1 overexpression suggesting that Dlk1/FA1 inhibits activation of TGF-β signaling pathway.. We used mouse embryonic limb bud culture as an in vitro system that spontaneously differentiates in culture without any exogenous chondrogenic inducers and recapitulates the sequential stages of chondrogenesis from condensing mesenchyme to matrix mineralization [24, 39, 40]. The ...
UBERON ,alt_id= ,comment=Editor notes - note the distinction between this and skeleton of limb ,created_by= ,def=Skeletal subdivision that is a segment of the limb skeleton. [VSAO:0005018, VSAO:NI] ,derives_from= ,develops_from= ,disjoint_from= ,has_quality= ,id=UBERON:0010712 ,is_a=UBERON:0010912 ,is_obsolete= ,located_in= ,name=limb skeleton subdivision ,namespace=FANTOM ,obo_creation_date= ,part_of=UBERON:0002101;;UBERON:0002091;;UBERON:0002101 ,preceded_by= ,property_value=IAO:0000412 ,subset= ,synonym= ,union_of= ,xref=VSAO:0005018 ...
Front legs do the split and go rigid - posted in Health and Genetics: 13 year old dog.. No previous health issures. In fact every morning hes out moving sheep around helping train the young dogs. The first time this happened was about 2 months ago. He stood up to look out the back door window and some how or other ended up on the floor. He was on his chest with his front legs straight out to the sides. Imagine doing a split. The odd thing was his lower legs was up off the floor. Alm...
Rostrum distinctly projecting anteroventrally in lateral view, but rounded in dorsal view; prodorsal ridges absent; interlamellar and exobothridial setae vestigial; sensilli with densely barbed clavate head and moderately long, narrow stalk; notogastral setae thin, smooth; setae much shorter than other notogastral setae. Surface of body and leg segments with thick cerotegument being very finely punctate on dorsal and ventral plates and having rather large granules on venter of pedotectum, on lateral part of prodorsum, and around leg acetabula. Rostrum rounded in dorsal view, but conspicuously projecting anteroventrally in lateral view ...
Question - I had a fracture at leg joint. I have severe pain. Kindly suggest. Ask a Doctor about diagnosis, treatment and medication for Bone fracture, Ask an Orthopaedic Surgeon
The stomach is distended and filled with granular food material. On the lateral projections, the pylorus is dorsally displaced and the fundus is positioned ventrally. On the v/d projection, the fundus is on the right of midline. The distal extremity of the spleen is dorsally displaced, and the proximal extremity is ventrally displaced on the lateral projections. It is not visible in its normal position on the v/d projection.The small intestine is caudally displaced and gas filled. The portion of the thorax included is normal ...
Nvisions Trigon Osteotomy Wedge system, along with the entire foot and ankle line, is incorporating multiple technologies that I believe will be major factors in the future of reconstructive distal extremity surgery, said Dr. Kyle Vaughn, founder of Paradise Valley Foot and Ankle in Phoenix Ariz. The Trigon system, made from PEEK-OPTIMA HA Enhanced, enables a standard surgical technique that allows direct and exact placement of implant and screws without additional plating. Nvision collaborated with Invibio for the FDA 510(k) submission to obtain clearance for the new implant. PEEK-OPTIMA HA Enhanced provides a potential for earlier fusion/union for foot and ankle implants, a surgeons primary goal for fusion surgery. It does so because Hydroxyapatite (HA) is fully integrated within the matrix of Invibios PEEK-OPTIMA Natural. As it is integrated, not coated, the HA is available on all surfaces of a finished device. In combination with a modulus of elasticity closely matching that of actual ...
Hypoglossia and aglossia are rare congenital malformations, especially when found as isolated abnormalities. In view of their usual association with other anomalies of the face, oral cavity, and distal extremities, an accurate investigation is requir
Zone of polarizing activity cells form a subset of cells in the posterior mesenchyme of the limb bud. They are the main source of SHH signaling in the developing limb ...
Our incredible Giant Spyder is now actor powered. Measuring 9 across, standing actor fits perfectly within the rear abdomen of the Spyder allowing them to drive the character and chase patrons without the need of a track. All movements are actor controlled/powered, so no need for air or electricity. This actor operated prop is the economy version with front leg articulation only. ...
My 9 month puppy went down a step, and I think he has a sprain in his left front leg, it happened this morning. He - Answered by a verified Dog Specialist
S1P1, a high affinity G-protein coupled receptor for bioactive lipid sphingosine 1-phosphate (S1P), regulates various cellular functions. However, little is known about the physiological roles of S1P1. To improve our understanding of the function of S1P1 in vivo, we investigated the role of S1P1 during limb development, S1P1 expression in the adult tissues, and S1P1 function in adult vasculature and angiogenesis. ^ During limb development, S1P1 is expressed in the vasculature and in mesenchymal tissues in the remodeling areas. S1P1 −/− limbs are hypervascularized and cartilage condensation was absent in the digit areas. The expression of VEGF and HIF-1α are highly elevated in S1P 1 −/− limbs. Endothelium specific S1P1 −/− limbs also exhibit same phenotype. These results indicate that impaired vascular function in S1P1 −/− limbs generates tissue hypoxia, resulting in abnormal limb development. ^ In normal adult tissues, S1P1 is ubiquitously expressed in various cell types, including
When a dog loses a limb, each of his other limbs has to carry more of his weight. The burden increases the most for the remaining leg on the same end of the dog as the amputated limb. Dogs carry about 60% of their weight on their front end. If you could compel a dog to stand with each foot on a separate scale, youd find each front limb holding up about 30% of their body weight apiece, and each hind leg holding up about 20% of their body weight. So, do the math: If one front limb is removed, the remaining front leg has to hold up a whopping 60% of the dogs body weight by itself! If a hind leg is removed, the remaining hind limb will need to carry about 40% of the dogs weight. This underscores the need to keep the dogs weight under strict control; you dont want any of the limbs to carry any more weight than they must. These dogs should always be kept thin.. Carrying an increased percentage of the dogs weight as he ambulates is not the only increased burden for his remaining limbs. A single ...
Correct Answer: When I try to text to a 5 digit number I get a message saying"Message+ would like to sand a message to xxxxx. This may cause
Kelley B. Vlahos: Oh, yeah. I mean, as a mother, this is a particular difficult story for me to do because every time that I went to do research, Googling birth defects Falluja I would indiscriminately get photographs of these babies that were born and were talking everything from congenital heart defects to what you would call skeletal malformations which could be pieces of the skull missing, missing eyes, missing limbs, additional limbs where there shouldnt be limbs, babies who are just lying there lifeless and limp because their heads are three, four times the size they should be. Things that you dont even want to see or ever hope to see, that will give you nightmares at night. And there are pictures and pictures and examples upon examples on the internet that, you know, I think most of us would probably -- not ignore, but never see unless we were investigating it ourselves. And this is sad because the evidence is there and we have basically, like you said earlier, have decided that the ...
J:89327 Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, Yamana K, Zanma A, Takada K, Ito Y, Komori T, Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004 Apr 15;18(8):952-63 ...
The answer is probably yes. There is a recent article in a medical journal* summarizing several studies addressing this question (a meta-analysis). This has been a source of arguments as to whether progesterone helps prevent miscarriage early on in pregnancy and many studies have said that it does. Unless you are on an unusually high dose it would be fine to continue. The only adverse effect of progesterone that I know of is extremely rare and that is an effect on limb growth. The best thing would be to ask your obstetrician what he or she recommends.. *Fertility and Sterility Volume107, Issue 2, Pages 430-438. ...
Investigators at Burnham Institute for Medical Research and the University of Connecticut Health Center have gained new understanding of the role hyaluronic acid plays in skeletal growth, chondrocyte maturation and joint formation in developing limbs.
Recently, together with my colleague Dr Jennifer Clack, (Coates and Clack,1990) I reported the discovery of polydactylous, Devonian tetrapod limbs: the forelimb of Acanthostega(Jarvik, 1952), and...
A 2-Digit number is squared. When this 2-digit number is reversed and squared, the difference between the squares is also a square. What is the 2-digit number?
From the MS, We replaced a limb-specific transcriptional enhancer of the mouse Prx1 locus with the orthologous sequence from a bat. Prx1 expression directed by the bat enhancer results in elevated transcript levels in developing forelimb bones and forelimbs that are significantly longer than controls ...
Hello my mother is now experiencing leg pain (broken bones). Shaped like a boil in it there is pus and blood but hard, then if the boil appears very
Hospital bills are too high, and insurance doesnt cover enough. Turns out, thats a crisis for hospitals too: more and more of us arent paying those bills, because we cant. So, theyre getting creative about collecting - and offering discounts. Which raises questions about why the bills are so high to begin with. Photo courtesy James Crannell We start with Chicago woodworker James Crannell, who - and theres no non-scary way to say this - stuck his finger in a table saw. Even more scary: He didnt have insurance.
in bed. The neurological examination highlighted: plegia of the left lower limb . The bending of the leg on the thigh on the ... difficulties to stand up, severe pain (legs), plegia (left lower limb), dorsiflexion (foot), Hypotonia (left lower limb), distal .... ...
Hello and thanks for reading, Well, I found a soft lump near the arm pit of my 5 (almost 6) year old female GSD this weekend. She seems very healthy
Daily News How Gaining and Losing Weight Affects the Body Millions of measurements from 23 people who consumed extra calories every day for a month reveal changes in proteins, metabolites, and gut microbiota that accompany shifts in body mass.. ...
Look up extremities or extremity in Wiktionary, the free dictionary. Extremities may refer to: The distal limb (forearm or ... tusk/mouthpart or raptorial Extremities (play), a 1982 play by William Mastrosimone Extremities (film), a 1986 film based on ... the play Extreme (disambiguation) This disambiguation page lists articles associated with the title Extremities. If an internal ...
Extremities at IMDb Extremities at AllMovie Extremities at the TCM Movie Database Review at TV Guide (Articles with short ... Extremities was released to Blu-ray and DVD on May 19, 2015 as a Region 1 widescreen disc. "Extremities". Box Office Mojo. ... Extremities is a 1986 American drama film directed by Robert M. Young and written by William Mastrosimone, based on his 1982 ... "Extremities (1986)". Rotten Tomatoes. Archived from the original on 3 March 2021. Retrieved 2 January 2021. "Worst of 1986". ...
Extremities (film) Rich, Frank (23 December 1982). "Stage: Miss Sarandon in 'Extremities'". The New York Times. Retrieved 11 ... ISBN 0-671-01899-X. "Production of Extremities , Theatricalia". "The Helen Mirren Archives - Career - Theatre - Extremities ( ... Extremities is an off-Broadway play by William Mastrosimone and directed by Robert Allan Ackerman. It opened at the Westside ... ISBN 0-451-16633-7. James Russo - Awards Archived 2012-10-20 at the Wayback Machine at Internet Broadway Database Extremities ...
... (1998) B.L.U.E. Nights (Live) (2000) (Use dmy dates from June 2016, Use British English from ... Bruford Levin Upper Extremities (B.L.U.E.) was a musical group consisting of drummer Bill Bruford, bassist Tony Levin, ...
Bruford Levin Upper Extremities is a self-titled album by the band Bruford Levin Upper Extremities. It is their only studio ... Bruford Levin Upper Extremities at AllMusic. Retrieved 20 June 2012. Joyce, Mike (10 April 1998). "Bill Bruford and Ton Levin: ... Aaron, S. Victor (28 September 2007). "One Track Mind: Bruford Levin Upper Extremities, "Cracking The Midnight Glass" (1999)". ... Melton, Jeff (1 July 1998). "Reviews: Bruford Levin - Upper Extremities". Exposé Online. Retrieved 30 November 2022. (Use dmy ...
Extremity at IMDb Extremity at Rotten Tomatoes (Articles with short description, Short description matches Wikidata, IMDb ID ... Extremity is a 2018 American horror film directed by Anthony DiBlasi, starring Chad Rook, Dana Christina and J. Larose. Chad ... Macomber, Shawn (1 October 2018). "MOVIE REVIEW: "EXTREMITY" LIVES UP TO ITS TITLE". Rue Morgue. Archived from the original on ... Leonard, Sean (25 April 2020). "FILM REVIEW: EXTREMITY (2018)". Archived from the original on 19 October 2021. ...
... is the eighth studio album by English post-punk band Killing Joke, released in ... Extremities, Dirt and Various Repressed Emotions was recorded in 1990 for a German independent label: bassist Paul Raven was ... Extremities, Dirt and Various Repressed Emotions at Discogs (list of releases) (Use dmy dates from April 2022, Articles with ... Extremities, Dirt and Various Repressed Emotions saw a return to prominent guitars after the synthesised sound on previous ...
... may refer to: Lower extremity of femur Upper extremity of femur This disambiguation page lists articles ... associated with the title Extremity of femur. If an internal link led you here, you may wish to change the link to point ...
The Berkeley Lower Extremity Exoskeleton (BLEEX) is a robotic device that attaches to the lower body. Its purpose is to ... Dollar, Aaron M.; Herr, Hugh (February 2008). "Lower Extremity Exoskeletons and Active Orthoses: Challenges and State-of-the- ... complement the user's strength by adding extra force to the user's lower extremity bodily movements. The BLEEX was funded by ...
The upper extremity, proximal extremity or superior epiphysis of the femur is the part of the femur closest to the pelvic bone ... Upper extremity of right femur viewed from behind and above, showing head, neck, and the greater and lesser trochanter Left hip ...
The lower extremity of femur (or distal extremity) is the lower end of the femur (thigh bone) in human and other animals, ... It is larger than the upper extremity of femur, is somewhat cuboid in form, but its transverse diameter is greater than its ... it is a small depression from which a smooth well-marked groove curves obliquely upward and backward to the posterior extremity ...
... (BLEIL) is a distinct clinical entity characterized by acute lymphedema in ... Bilateral lower extremity inflammatory lymphedema is described in otherwise healthy young adults undergoing recruit training ... McCann, Shannan E.; Dalton, Scott R.; Kobayashi, Todd T. (May 2017). "Histopathology of bilateral lower extremity inflammatory ... "Bilateral Lower Extremity Inflammatory Lymphedema in Air Force Basic Trainees: Clinical and Epidemiologic Study of a New ...
... , sometimes called lower extremity-predominant spinal muscular atrophy ... may refer to: Spinal muscular atrophy with lower extremity predominance 1 Spinal muscular atrophy with lower extremity ... atrophies This disambiguation page lists articles associated with the title Spinal muscular atrophy with lower extremity ... predominance 2A Spinal muscular atrophy with lower extremity predominance 2B Spinal muscular ...
... is a peer-reviewed academic journal that publishes papers four times a year ... The International Journal of Lower Extremity Wounds is interdisciplinary and aims to appeal to a wide audience of those ... The International Journal of Lower Extremity Wounds is abstracted and indexed in the following databases: CINAHL EMBASE MEDLINE ... The International Journal of Lower Extremity Wounds publishes original research, reviews of evidence-based diagnostic ...
... (SMALED1) is an extremely rare neuromuscular disorder of infants ... Spinal muscular atrophies Spinal muscular atrophy with lower extremity predominance 2A Spinal muscular atrophy with lower ... "Dominant spinal muscular atrophy with lower extremity predominance: Linkage to 14q32". Neurology. 75 (6): 539-546. doi:10.1212/ ... "A DYNC1H1 mutation causes a dominant spinal muscular atrophy with lower extremity predominance". Neurogenetics. 13 (4): 327-332 ...
There is no known cure for SMALED2A.[citation needed] Spinal muscular atrophies Spinal muscular atrophy with lower extremity ... Spinal muscular atrophy with lower extremity predominance 2A (SMALED2A) is a rare neuromuscular disorder characterised by ... predominance 1 Spinal muscular atrophy with lower extremity predominance 2B Online Mendelian Inheritance in Man (OMIM): 615290 ...
... (SMALED2B) is a rare neuromuscular disorder characterised by ... Spinal muscular atrophies Spinal muscular atrophy with lower extremity predominance 1 Spinal muscular atrophy with lower ... extremity predominance 2A Online Mendelian Inheritance in Man (OMIM): 618291 Koboldt, Daniel C.; Kastury, Rama D.; Waldrop, ...
She took a master's degree in creative writing from San Francisco State University, and wrote Extremities (1978), her first ... Collections Armantrout, Rae (1978). Extremities. The Figures. - (1979). The invention of hunger. Tuumba. - (1985). Precedence. ...
Later that year, she costarred in Extremities with Farrah Fawcett. Luft appeared as Nurse Libby Kegler on the CBS television ... "Extremities". Lortel Archives. Retrieved March 11, 2018. "Luft records duets with mom Garland". Variety. October 20, 1995. ...
... cold extremities; decreased consciousness); tachypnea (pneumonia, heart failure); abdominal manifestations (distension, ...
"Extremities - YouTube". Retrieved November 7, 2022. Anderson, Pearse. "This Travel Game Takes Connect Four to ... In June 2019, Denby created a scripted podcast called Extremities about the logistics of living in the world's most isolated ... Scott, Richard (July 5, 2019). "'Extremities': taking you to the world's most isolated places" (Audio). Radio New Zealand. The ... Extremities, and Jet Lag: The Game. Across all of Denby's channels, he has accumulated more than a billion views. As of ...
"Overview:Extremities". Allmovie. Retrieved July 23, 2010. Deming, Mark. "Overview:F/X". Allmovie. Retrieved July 23, 2010. ...
"Extremities Quarterly , Phallumegaly - Lorenzo von Matterhorn". Archived from the original on ...
"Continental extremities". Geoscience Australia. 15 May 2014. Retrieved 2 April 2021. "Parks and Reserves-Australia's National ...
"Phallumegaly - Lorenzo von Matterhorn". Extremities Quarterly. Retrieved August 13, 2017. How I Met Your Mother - "The Playbook ...
"VAIN EXTREMITIES". Retrieved 22 February 2020. Artist's website v t e (Articles with short ...
"Climatic Extremities in Nepal". Compendium of Environmental Statistics Nepal 2015. Central Bureau of Statistics. 2016. pp. 43- ...
Cilia whitish at extremities. Hindwings ochreous, fuscous towards outer margin, with patches of pink on vein 1 and at anal ...
"Climatic Extremities in Nepal". Compendium of Environmental Statistics Nepal 2015. Central Bureau of Statistics. 2016. pp. 43- ...
The Extremities. McGraw-Hill Professional. p. 417. ISBN 0-8385-2210-6. (Articles with short description, Short description ...
Arteriosclerosis of the extremities is a disease of the peripheral blood vessels that is characterized by narrowing and ... Atherosclerosis of the extremities is a disease of the peripheral blood vessels that is characterized by narrowing and ...
Lower-extremity amputation is one of the oldest known surgically performed procedures. The original surgical principles as ... Lower Extremity Assessment Project (LEAP)--the best available evidence on limb-threatening lower extremity trauma. Orthop Clin ... encoded search term (Lower-Extremity Amputations) and Lower-Extremity Amputations What to Read Next on Medscape ... Lower-Extremity Amputations. Updated: Apr 29, 2021 * Author: Janos P Ertl, MD; Chief Editor: Vinod K Panchbhavi, MD, FACS, FAOA ...
Lower extremity foot ulcers and amputations in diabetes. In: Harris MI, Cowie CC, Stern MP, et al, eds. Diabetes in America. ... Diabetes-Related Amputations of Lower Extremities in the Medicare Population -- Minnesota, 1993-1995 Diabetes mellitus is the ... Lower-extremity amputation in people with diabetes: epidemiology and prevention. Diabetes Care 1989;12:24-31. ... Editorial Note: The diabetes-related lower extremity conditions that increase the risk for amputation among persons with ...
Onstage: Extremities This will be a test. Following a sold-out summer of musicals, the Incline Theater turns to far more ...
The Lower Extremity Disease Examination data will be used to determine the prevalence of lower extremity disease in the U.S. ... Lower Extremity Disease - Peripheral Neuropathy (LEXPN) Data File: LEXPN.xpt First Published: June 2002. Last Revised: NA ... Participants 40 years of age and older are asked to participate in the PN Section of the Lower Extremity Disease examination. ... The Ankle Brachial Blood Pressure Index (ABPI) section of the Lower Extremity Disease component collects data on peripheral ...
Lower-extremity amputation is one of the oldest known surgically performed procedures. The original surgical principles as ... Lower Extremity Assessment Project (LEAP)--the best available evidence on limb-threatening lower extremity trauma. Orthop Clin ... encoded search term (Lower-Extremity Amputations) and Lower-Extremity Amputations What to Read Next on Medscape ... Lower-Extremity Amputations. Updated: Apr 29, 2021 * Author: Janos P Ertl, MD; Chief Editor: Vinod K Panchbhavi, MD, FACS, FAOA ...
Background: The effect of amputation on the social and psychological well-being of patients has been established. How- ever, the experiences and needs of amputees for the process of adjustment varies among individuals and ...
Duffey and others published LOAD SUPPORTED BY THE UPPER EXTREMITIES DURING INCLINE AND DECLINE PUSHUPS , Find, read and cite ... study was to determine the load supported by the upper extremities during these activities. ... load supported by the upper extremity increased an average of 13.5% Body Weight (BW) for each ... LOAD SUPPORTED BY THE UPPER EXTREMITIES DURING INCLINE AND DECLINE PUSHUPS. *May 2003 ...
EXTREMITIES, LIMBS indications, uses & symptoms from 12 cross linked materia medicas. Available 3C-30C, 200C, 6X-30X, 1M-10M ... EXTREMITIES, LIMBS. Extremities, limbs. Drawing, tensive pain in thighs and legs, with restlessness, sleeplessness, and ... Pulsatilla - Extremities, Limbs symptoms Pulsatilla Nigricans, Pulsatila, Pratensis, Wind Flower, Pulsat, Pasque Flower, Puls. ... Extremities, Limbs. Rectum, Anus, Stool Genitals Etc Generalities Fever And Chill Injuries And Accidents. Materia Medica ...
EXTREMITIES, LIMBS indications, uses & symptoms from 12 cross linked materia medicas. Available 3C-30C, 200C, 4X-30X, 1M-10M ... EXTREMITIES, LIMBS. Extremities, limbs. Twitching and jerking distortion of limbs, trembling. Paralyzed shocks; patient will ...
Search terms included 3 themes: robotics; SCI; and upper extremity. Studies using robots for upper extremity rehabilitation ... after major lower extremity trauma and 13 control subjects who had no lower extremity trauma and wore no orthosis underwent ... Powered upper extremity range of motion assist device, elbow, wrist, hand with single or double upright(s), includes ... Powered upper extremity range of motion assist device, elbow, wrist, hand, finger, single or double upright(s), includes ...
This area of the human body is uniquely complex and includes the joints, bones and muscles of the fingers, hand, wrist, arm, elbow and shoulder. Its intricate and mobile design, coupled with the use and abuse sustained each day, can make this region of the body highly susceptible to injury.. Suburban Hospital Orthopaedic Care offers a specialized skill set of evaluation, treatment and rehabilitation. Our staff works together to diagnose and effectively treat the problem to ensure that the recovery process is effective and efficient.. Our surgical team specializes in the treatment of:. ...
... practical information on todays advances in hand and upper extremity surgery. It features articles by leading experts on the ... Techniques in Hand & Upper Extremity Surgery. You may be trying to access this site from a secured browser on the server. ...
... Prosthetic Restoration and Rehabilitation of the Upper and Lower Extremity ... title={UPPER EXTREMITY ANATOMY, KINESIOLOGY, AND FUNCTION},. author={Mogk, Jeremy PM},. journal={Prosthetic Restoration and ... Rehabilitation of the Upper and Lower Extremity},. pages={115},. year={2013},. publisher={Demos Medical Publishing}. } ...
Upper Extremity Arteriogram. Upper Extremity Arteriogram. - Discussion:. - it is important that the injection site be at ...
... are at risk for lower extremity ischemia. Effective monitoring is needed to identify complications quickly and allow timely ... We present its use in monitoring lower extremity perfusion in patients on ECMO. Five patients on ECMO had near-infrared ... Two patients had lower extremity complications in the leg with the arterial cannula. The patients with complications had lower ... The use of near-infrared spectroscopy for continuous monitoring of tissue oxygenation in the lower extremities in patients on ...
New SoMa Extremity: Stereo Argento at The Stud. Halloween gets especially ghoulish at a drag-and-movie night with plenty of ... More recently, at a Stereo Argento devoted to the genre of early-2000s European cinema known as the New French Extremity, ...
Palpable Structures of the Lower Extremities. Can you name the Palpable Structures of the Lower Extremities. ...
bebionic, Myobock prosthetic system for adults, Myobock prosthetic system for children, Dynamic ...
The Roto and Paznina clans meet on the battlefield to ensure that only one remains when all the blood is shed.
Intermittent claudication is the hallmark of atherosclerotic lower extremity PAD, but only about 10% of patients with PAD ... Lower extremity peripheral artery disease (PAD) affects 12% to 20% of Americans 60 years and older. The most significant risk ... The primary treatment strategies for lower extremity PAD include the following:. Lifestyle modifications. C. 9, 24-31 Based on ... Vascular examination should include palpation of lower extremity pulses and auscultation for femoral bruits.. C. 9 Based on ...
Shop the Extremities Marwood Mitts at Shop online or in-store for some of the UKs favourite products. ... Extremities Marwood Mitts. The Marwood Mitt has been designed with full comfort in mind whilst providing warmth and ...
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Copyright © 2022 BMJ Publishing Group Ltd and the College of Emergency Medicine. All rights reserved.. ...
Multidrug-Resistant Acinetobacter Extremity Infections in Soldiers. Emerging Infectious Diseases. 2005;11(8):1218-1224. doi: ... Davis, K. A., Moran, K. A., McAllister, C., & Gray, P. J. (2005). Multidrug-Resistant Acinetobacter Extremity Infections in ... Multidrug-Resistant Acinetobacter Extremity Infections in Soldiers. Volume 11, Number 8-August 2005 ... This increase and the influx of severe extremity infection due to MDR Acinetobacter species posed considerable challenges. The ...
There are 2 articulations that make up the talocrural joint. 1) formed by the distal end of the tibia and talus. 2) formed when the lateral malleolus of the fibula meets the talus. ...
... interventions that effectively prevent and manage upper extremity MSDs. ... Upper extremity musculoskeletal disorders (MSDs) include painful conditions and injuries of the muscles, tendons, joints and ... Work-related upper extremity musculoskeletal disorders (MSDs) are common and costly. In Canada, upper extremity MSDs and low- ... Upper extremity MSDs are complex, with multiple physical, psychosocial and personal causes. Therefore, the review team and ...
Epidermolysis bullosa acquisita (EBA) is an acquired, primary blistering disorder. Making the correct diagnosis required a conglomeration of clinical, histological and laboratory findings.. When faced with cutaneous blisters, one must consider multiple diagnoses ranging from poison ivy to an acquired primary blistering disorder. History, physical exam, and initial histologic findings can often determine that a primary blistering disorder is present, but then the real work begins because the number of conditions to be considered among the primary blistering diseases is quite large, and sometimes confusing. Using clinical clues, histologic findings, and various laboratory results, the correct diagnosis usually can be determined. During the physical exam, the clinician should note the size, locations, and quality of the blisters, as well as inspect the mucous membranes. In addition to standard hematoxylin and eosin (H&E) staining, histologic evaluation must include direct immunofluorescence (DIF) ...
The Lower Extremity Disease examination data will be used to determine the prevalence of lower extremity disease in the U.S. ... Lower Extremity Disease - Ankle Brachial Blood Pressure Index (LEXAB_C) Data File: LEXAB_C.xpt First Published: December 2005. ... Participants 40 years of age and older are asked to participate in the ABPI Section of the Lower Extremity Disease examination ... For the procedures relevant to this component, please go to the Lower Extremity Disease Procedures Manual on the NHANES website ...
  • study was to determine the load supported b y the upper extremities during these activities. (
  • DVT involve the upper extremities, resulting in an annual incidence of 0.4 to 1 case per 10,000 people," writes Nils Kucher, MD, from the Departments of Angiology and Cardiology, Cardiovascular Division, Inselspital, University Hospital Bern in Bern, Switzerland. (
  • Complications of DVT occur less often in the upper extremities vs the lower extremities, but these may include pulmonary embolism, recurrence at 12 months, and post-thrombotic syndrome. (
  • Complete arteriography of both upper extremities is necessary to establish the diagnosis and plan effective treatment. (
  • Diabetes mellitus is the leading cause of nontraumatic lower-extremity amputations (LEAs) in the United States and accounts for 45%-70% of all nontraumatic LEAs (1,2). (
  • The hypothesis of this research protocol is that we will be able to redesign the manner in which lower limb amputations are performed so as to include biological actuators that will enable the successful employment of next generation lower extremity prostheses. (
  • The aim of this work was to study the incidence over time of lower extremity amputations and determine variables associated with increased risk of amputations in people with type 1 diabetes. (
  • These programs attempt to reduce the burden of diabetes by preventing blindness, lower-extremity amputations, cardiovascular disease, and adverse outcomes of pregnancy among persons with diabetes. (
  • The Lower Extremity Disease Examination data will be used to determine the prevalence of lower extremity disease in the U.S. population (diagnosed and undiagnosed), including those at high risk for the late complications of the disease (i.e., ulceration and amputation). (
  • The estimated cost to the Army for lower extremity fractures in 2017 was approximately $116 million. (
  • The product complements Extremity Medical's planned 2017 launches, such as the AXIS Charcot Fixation, KinematX Total Wrist Arthroplasty, MTP fusion and Jones fracture systems. (
  • What workplace programs help prevent upper extremity musculoskeletal disorders? (
  • We recommend implementing a workplace-based resistance training exercise program, based on strong evidence that these programs can help prevent and manage upper extremity musculoskeletal disorders (MSDs) and symptoms. (
  • Upper extremity musculoskeletal disorders (MSDs) include painful conditions and injuries of the muscles, tendons, joints and nerves that affect the neck, shoulders, elbows, wrists and hands. (
  • Work-related upper extremity musculoskeletal disorders (MSDs) are common and costly. (
  • Upper-extremity musculoskeletal disorders: how many cases can be prevented? (
  • Lower-extremity amputation is one of the oldest known surgically performed procedures, dating back to prehistoric times. (
  • Lower extremity amputation is among the oldest known surgical procedures in medical history. (
  • 1 insensate area), foot ulcers, or lower-extremity amputation. (
  • Following approval by the AO Trauma Education Commission this year, the AO Trauma Lower Extremity Education Taskforce of international program editors (IPEs) and regional program contributors (RPCs) have worked on finalizing the program and the support materials for lower extremity trauma courses for both practicing surgeons and experts for full global rollout. (
  • Besides the comprehensive 3-day AO Trauma Masters Course-Lower Extremity Trauma (With Anatomical Specimens), three more specialized courses on the femur, the knee, and the tibia and fibula are envisaged, and templates for those are being developed. (
  • Any feedback on the framework and material is highly valued and can be shared with the AO Trauma Lower Extremity Education Taskforce via Barbara Niederee . (
  • Kim W. Imaging of extremity trauma. (
  • Currently, lower limb amputation is indicated most frequently for lower extremity compromise due to severe peripheral vascular disease, followed in short order by trauma, tumors, infections and congenital limb deficiencies. (
  • The SixFix Circular Fixation System is a platform that can address extremity applications in trauma, foot and ankle, and deformity correction for both adults and pediatrics. (
  • Amputation is the treatment of choice for diseased limbs and devastating lower-extremity injuries for which attempts at salvage and reconstruction may be lengthy, have high emotional and financial costs, and yield a less-than-satisfactory result. (
  • In Canada, upper extremity MSDs and low-back pain are the leading causes of disabling work-related injuries. (
  • The analyses focused on lower extremity fractures, in particular, because such injuries are considered by both the Army safety and health communities to be a high-visibility, high priority concern. (
  • In looking through his injury logs, Jim notices most of his employee injuries occurred to the lower extremities, not the trunk like the Bureau of Labor Statistics data indicate. (
  • He decides to contact an occupational safety and health consultant to help him determine why his plant is experiencing high rates of lower extremities injuries. (
  • These organisms were the most frequently recovered gram-negative isolate from war wounds and the second most frequent bacterium causing bloodstream infection in US Marines with extremity wounds during the Vietnam War ( 3 ). (
  • Gunshot wounds to the lower extremity. (
  • Patients on peripheral extracorporeal membrane oxygenation (ECMO) are at risk for lower extremity ischemia. (
  • Patients who present with upper-extremity ischemia range from young adults with nonatherosclerotic causes to elderly patients with atherosclerosis. (
  • This analysis is centered on acute fractures of the lower extremities. (
  • For acute upper extremity DVT, anticoagulation therapy should be started promptly, for example, with LMWH once daily. (
  • One third of peripheral emboli lodge in the upper extremity, producing acute arterial occlusion. (
  • Editorial Note: The diabetes-related lower extremity conditions that increase the risk for amputation among persons with diabetes include peripheral neuropathy, peripheral vascular disease, and infection (5). (
  • The major manifestations of lower extremity disease are peripheral vascular disease and peripheral neuropathy. (
  • The Ankle Brachial Blood Pressure Index (ABPI) section of the Lower Extremity Disease component collects data on peripheral vascular disease and the Peripheral Neuropathy (LEXPN) section of the Lower Extremity Disease component collects data on peripheral neuropathy. (
  • Vascular examination should include palpation of lower extremity pulses and auscultation for femoral bruits. (
  • In a prospective pilot study, Sumpio et al evaluated the use of hyperspectral imaging (HSI), a technology that noninvasively measures oxygenated hemoglobin and deoxygenated hemoglobin concentrations in the skin, for demonstrating upper-extremity vascular dysfunction in patients with peripheral artery disease (PAD) and coronary artery disease (CAD). (
  • We present its use in monitoring lower extremity perfusion in patients on ECMO. (
  • Five patients on ECMO had near-infrared spectroscopy monitors placed on the calf of both lower extremities. (
  • Two patients had lower extremity complications in the leg with the arterial cannula. (
  • The use of near-infrared spectroscopy for continuous monitoring of tissue oxygenation in the lower extremities in patients on ECMO may allow early identification of patients with lower extremity complications. (
  • Intermittent claudication is the hallmark of atherosclerotic lower extremity PAD, but only about 10% of patients with PAD experience intermittent claudication. (
  • A D-dimer test is not recommended to screen patients with suspected upper extremity DVT, because many of these patients have coexisting conditions associated with an elevated D-dimer level. (
  • The preferred imaging test for patients with suspected upper extremity DVT is compression ultrasonography, although overlying bony structures often hinder visualization of the proximal subclavian and brachiocephalic veins. (
  • Routine catheter removal is not recommended for patients with catheter-associated thrombosis, but it is generally indicated when the catheter malfunctions or is infected, when anticoagulation therapy is contraindicated, when evidence of upper extremity DVT persists during initial anticoagulation therapy, or when the catheter is no longer needed. (
  • data from trials involving patients with thrombosis of a lower extremity are used to guide management. (
  • At some centers, patients with upper extremity DVT undergo staged multidisciplinary treatment. (
  • Indocyanine green fluorescent imaging has been described as a noninvasive means of characterizing and quantifying microcirculatory disorders in patients with peripheral arterial occlusive disease of the upper extremity. (
  • In this prospective, observational study , all patients undergoing lower extremity revascularization (endovascular or open) were included from December 2020 to February 2022. (
  • Tardive dyskinesias (TDs) are involuntary movements of the tongue, lips, face, trunk, and extremities that occur in patients treated with long-term dopaminergic antagonist medications. (
  • The most common part of the body involved was the extremities in 63.3% of patients . (
  • Atherosclerosis of the extremities is a disease of the peripheral blood vessels that is characterized by narrowing and hardening of the arteries that supply the legs and feet. (
  • Participants 40 years of age and older are asked to participate in the PN Section of the Lower Extremity Disease examination. (
  • Refer to Lower Extremity Disease Procedures Manual for further details. (
  • Lower extremity peripheral artery disease (PAD) affects 12% to 20% of Americans 60 years and older. (
  • Atherosclerotic lower extremity artery occlusive disease-commonly referred to as peripheral artery disease (PAD)-affects 12% to 20% of Americans 60 years and older, increasing to nearly 50% in those 85 years and older. (
  • Arterial occlusive disease of the upper extremity may represent either local or systemic disease. (
  • Symptomatic upper-extremity arterial occlusive disease is uncommon because of the abundant collateral network and the infrequency of atherosclerosis in the upper extremity. (
  • Impact of socioeconomic disparities on major lower extremity revascularization complications. (
  • March 14, 2011 - Anticoagulation therapy should be started promptly for upper extremity deep-vein thrombosis (DVT), according to a clinical practice review of upper extremity DVT published in the March 3 issue of the New England Journal of Medicine . (
  • AFM is an illness that's characterized by the sudden onset of flaccid weakness in one or more extremities and also by distinct longitudinal gray matter lesions in the spinal cord. (
  • Corticospinal lesions above the pyramidal decussation typically result in paralysis of volitional movements of the contralateral half of the body and a fixed posture with flexion of the upper extremity and extension of the lower extremity. (
  • Bilateral corticospinal lesions of the upper pons and midbrain typically cause extension of all 4 extremities and decerebrate rigidity with dorsiflexion of the cervical and thoracolumbar spine. (
  • Noninvasive laboratory studies include bilateral upper-extremity arm, forearm, and digital blood pressures. (
  • Poor perfusion due to hypotension, hypovolemic shock, or cold extremities. (
  • Congenital anomalies of the lower extremity. (
  • We aimed to analyze the frequency of locomotor apparatus congenital anomalies (extremities) in maternities of the city of Maceió. (
  • In their native state, the muscles of the lower extremity exist in a balanced agonist/antagonist milieu in which volitional activation of one muscle leads not only to its contracture, but also passive stretch of its opposite. (
  • Hand and upper-extremity surgery is a subspecialty of orthopedics for which extensive training is required. (
  • We suggest you consider the following practices, if applicable to your work context, based on moderate evidence that these practices can help prevent and manage upper extremity MSDs and symptoms: stretching exercise programs, workstation forearm supports and vibration feedback on mouse use. (
  • She required multiple surgical debridement procedures for necrotic skin ulcers on her lower extremities. (
  • For instance, in February 2020, AMDT Holdings Inc., developer of extremity products, has launched SixFix Circular Fixation System. (
  • The various embodiments of the system are capable of providing adequate compression in the medial, central and/or lateral columns and/or sides of the foot, ankle, and/or lower extremity, as well as treating Charcot neuroarthropathy, fractures, revisional foot and combination of ankle surgeries. (
  • This study found that indirect medical costs (i.e., loss of return on personnel salary) cost the Army nearly 4 times the amount spent on direct medical care for soldiers' lower extremity fractures. (
  • The finding that the majority of costs related to lower extremity fractures were due to estimated days of lost or limited duty and associated loss of productivity justifies the inclusion of indirect cost estimates as a part of overall injury cost calculations. (
  • Faculty chairing lower extremity courses in 2022-2023 are asked to utilize the available material for course planning and delivery. (
  • Therapy that incorporates active assistance of motor tasks is a common technique in upper extremity rehabilitation after stroke. (
  • Lower extremity assistive devices (LEADs) have been developed in various fields, such as rehabilitation, military, and industry, in the form of exoskeleton robots or treadmills, and most of them are aimed at supporting muscle strength. (
  • However, the standard operative approach to lower limb amputation at either the below knee (BKA) or above knee (AKA) level obliterates many of the dynamic relationships characteristic of the uninjured lower extremity. (
  • Additionally, this course will take those unique properties of water to provide a comprehensive progression for various lower extremity conditions. (
  • DVT of an upper extremity and to prevent thrombus progression, early recurrence, pulmonary embolism, and the post-thrombotic syndrome," Dr. Kucher writes. (
  • Can a Chiropractor Treat the Extremities (Arms and Legs)? (
  • The present devices, systems and processes can simultaneously reduce a malady of the foot, ankle, and/or lower extremity and provide compression and stabilization through the use of a combined internal fixation device, external fixation device and a lower extremity stabilizing device. (
  • Extremity Medical launched BioFuse, a next-gen viable cell bone graft for use in the foot, ankle, wrist and hand. (
  • The external fixation device and/or lower extremity stabilizer can be removed after a certain period of time, leaving the internal fixation system within the body for prolonged stabilization and maintenance of the arthrodesis site(s). (
  • While lower extremity diagnoses are commonly referred for aquatic interventions, are the properties of water applied to maximize a patient's benefit. (
  • The mature female worm migrates to the surface of the skin over any part of the body, but most commonly the extremities, where it produces a painful blister that ruptures when it comes in contact with water. (
  • Identify key components of aquatic therapy that positively impact lower extremity(LE) diagnoses and logical progressions for the use of this intervention. (
  • And most specifically, our team at Community Chiropractic Center includes Dr. Rich Doss who has advanced certification (C.C.E.P.) in Extremity Therapy and Adjustments. (
  • An example of a classic disorder of the pyramidal system is a stroke, resulting in paralysis of an extremity. (
  • Some of the most common questions we hear involve the care that we provide to the extremities. (
  • We also suggest you consider alternatives to the following practices, based on moderate evidence that they have no effect on upper extremity MSDs: electromagnetic (EMG) biofeedback, job stress management and office workstation adjustments on their own (i.e. with minimal worker involvement). (
  • Except for suggesting that workplaces consider using arm supports, based on moderate evidence that they can help reduce upper extremity MSDs, the IWH systematic review team could make no other recommendations to practitioners based on the research findings available at the time. (