Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
The chemical and physical integrity of a pharmaceutical product.
Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.
The quality or state of being wettable or the degree to which something can be wet. This is also the ability of any solid surface to be wetted when in contact with a liquid whose surface tension is reduced so that the liquid spreads over the surface of the solid.
SURFACE-ACTIVE AGENTS that induce a dispersion of undissolved material throughout a liquid.
Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.
A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
A complex mixture of PHOSPHOLIPIDS; GLYCOLIPIDS; and TRIGLYCERIDES; with substantial amounts of PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; and PHOSPHATIDYLINOSITOLS, which are sometimes loosely termed as 1,2-diacyl-3-phosphocholines. Lecithin is a component of the CELL MEMBRANE and commercially extracted from SOYBEANS and EGG YOLK. The emulsifying and surfactant properties are useful in FOOD ADDITIVES and for forming organogels (GELS).
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.
Relating to the size of solids.
Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents. For reasons of their ingredients, method of preparation, or use, they do not fall into another group of products.
Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.
Technique whereby the weight of a sample can be followed over a period of time while its temperature is being changed (usually increased at a constant rate).
GLYCEROL esterified with a single acyl (FATTY ACIDS) chain.
The process of keeping pharmaceutical products in an appropriate location.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.
Removal of moisture from a substance (chemical, food, tissue, etc.).
Compounds that provide LUBRICATION between surfaces in order to reduce FRICTION.
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.
A plant genus of the family CYPERACEAE. SESQUITERPENES are found in some of the species.
A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.
The mechanical property of material that determines its resistance to force. HARDNESS TESTS measure this property.
A device that delivers medication to the lungs in the form of a dry powder.
A measure of the amount of WATER VAPOR in the air.
Method of using a polycrystalline powder and Rietveld refinement (LEAST SQUARES ANALYSIS) of X-RAY DIFFRACTION or NEUTRON DIFFRACTION. It circumvents the difficulties of producing single large crystals.
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
An aromatic perennial plant species that has been used to treat migraines, arthritis, and as a febrifuge. It contains TANNINS, volatile oils (OILS, ESSENTIAL), and sesquiterpene lactones, especially parthenolide.
Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants.
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids. (Stedman, 25th ed)
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Salts and esters of the 12-carbon saturated monocarboxylic acid--lauric acid.
A test to determine the relative hardness of a metal, mineral, or other material according to one of several scales, such as Brinell, Mohs, Rockwell, Vickers, or Shore. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A plant genus of the family COMBRETACEAE. Members contain arjunin, an ellagitannin (TANNINS).
Hard or soft soluble containers used for the oral administration of medicine.
Substances added to foods and medicine to improve the quality of taste.
A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.
Insulin derivatives and preparations that are designed to induce a rapid HYPOGLYCEMIC EFFECT.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)
A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A change of a substance from one form or state to another.
A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
A polyester used for absorbable sutures & surgical mesh, especially in ophthalmic surgery. 2-Hydroxy-propanoic acid polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with 1,4-dioxane-2,5-dione copolymer of molecular weight about 80,000 daltons.
Flammable, amorphous, vegetable products of secretion or disintegration, usually formed in special cavities of plants. They are generally insoluble in water and soluble in alcohol, carbon tetrachloride, ether, or volatile oils. They are fusible and have a conchoidal fracture. They are the oxidation or polymerization products of the terpenes, and are mixtures of aromatic acids and esters. Most are soft and sticky, but harden after exposure to cold. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
A generic term for a variety of compounds that contain silicon, oxygen, and magnesium, and may contain hydrogen. Examples include TALC and some kinds of ASBESTOS.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.
The presence of organisms, or any foreign material that makes a drug preparation impure.
Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.
The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.

Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4. (1/728)

1. The effect of IL-4 on responses to intraplantar (i.pl.) carrageenin, bradykinin, TNFalpha, IL-1beta, IL-8 and PGE2 was investigated in a model of mechanical hyperalgesia in rats. Also, the cellular source of the IL-4 was investigated. 2. IL-4, 30 min before the stimulus, inhibited responses to carrageenin, bradykinin, and TNFalpha, but not responses to IL-1beta, IL-8 and PGE2. 3. IL-4, 2 h before the injection of IL-1beta, did not affect the response to IL-1beta, whereas IL-4, 12 or 12+2 h before the IL-1beta, inhibited the hyperalgesia (-30%, -74%, respectively). 4. In murine peritoneal macrophages, murine IL-4 for 2 h before stimulation with LPS, inhibited (-40%) the production of IL-1beta but not PGE2. Murine IL-4 (for 16 h before stimulation with LPS) inhibited LPS-stimulated PGE2 but not IL-1beta. 5. Anti-murine IL-4 antibodies potentiated responses to carrageenin, bradykinin and TNFalpha, but not IL-1beta and IL-8, as well as responses to bradykinin in athymic rats but not in rats depleted of mast cells with compound 40/80. 6. These data suggest that IL-4 released by mast cells limits inflammatory hyperalgesia. During the early phase of the inflammatory response the mode of action of the IL-4 appears to be inhibition of the production TNFalpha, IL-1beta and IL-8. In the later phase of the response, in addition to inhibiting the production of pro-inflammatory cytokines, IL-4 also may inhibit the release of PGs.  (+info)

The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. (2/728)

1. We have studied the behavioural effects of intraplantar injections of adenosine 5'-triphosphate (ATP) and related compounds in freely moving rats and investigated whether these nociceptive effects are augmented in the presence of inflammatory mediators. 2. We find that in normal animals ATP and analogues produce dose-dependent nocifensive behaviour (seen as bursts of elevation of the treated hindpaw), and localized thermal hyperalgesia. The rank order of potency was: alpha,beta-methyleneadenosine 5'-triphosphate (alpha,beta-methylene ATP) > 2-methylthioadenosine triphosphate (2-methylthio ATP) > ATP. After neonatal treatment with capsaicin, to destroy small calibre primary sensory neurones, nocifensive behaviour was largely absent. 3. The effects of ATP analogues were assessed in three models of peripheral sensitization: 2 h after dilute intraplantar carrageenan (0.25% w v(-1)); 24 h after irradiation of the hindpaw with ultraviolet (U.V.) B; immediately following prostaglandin E2 (PGE2) treatment. In all models the effect of alpha,beta-methylene ATP was greatly augmented. After carrageenan, significant hindpaw-lifting behaviour activity was induced by injection of only 0.05 nmol of alpha,beta-methylene ATP, some 100 times less than necessary in normal skin. 4. Our data suggest that it is much more likely that endogenous levels of ATP will reach levels capable of exciting nociceptors in inflamed versus normal skin. Our data also suggest the involvement of P2X3 receptor subunits in ATP-induced nociception.  (+info)

A study of local anaesthetics. Part 148. Influence of auxiliary substances on the surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII. (3/728)

The influence of auxiliary substances of the polyol group (glycerol, propylene glycol, sorbitol) and of their concentration (5, 10, 15 and 20% by weight) upon surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII, viz., N-[2-(2-propoxyphenylcarbamoyloxy)-ethyl] piperidinium chloride was studied. The substances were applied as hydrogel humectants. It was found that their influence on the surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII depended on the type as well as concentration of the auxiliary substance. From the viewpoints of use in formulations of the drug form, sorbitol used at 5 and 10% concentrations represented the optimum.  (+info)

Beneficial effects of raxofelast (IRFI 016), a new hydrophilic vitamin E-like antioxidant, in carrageenan-induced pleurisy. (4/728)

1. Peroxynitrite is a strong oxidant that results from reaction between NO and superoxide. It has been recently proposed that peroxynitrite plays a pathogenetic role in inflammatory processes. Here we have investigated the therapeutic efficacy of raxofelast, a new hydrophilic vitamin E-like antioxidant agent, in rats subjected to carrageenan-induced pleurisy. 2. In vivo treatment with raxofelast (5, 10, 20 mg kg(-1) intraperitoneally 5 min before carrageenan) prevented in a dose dependent manner carrageenan-induced pleural exudation and polymorphonuclear migration in rats subjected to carrageenan-induced pleurisy. Lung myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels, as well as histological organ injury were significantly reduced by raxofelast. 3. Immunohistochemical analysis for nitrotyrosine, a footprint of peroxynitrite, revealed a positive staining in lungs from carrageenan-treated rats. No positive nitrotyrosine staining was found in the lungs of the carrageenan-treated rats, which received raxofelast (20 mg kg 1) treatment. 4. Furthermore, in vivo raxofelast (5, 10, 20 mg kg(-1)) treatment significantly reduced peroxynitrite formation as measured by the oxidation of the fluorescent dihydrorhodamine 123, prevented the appearance of DNA damage, the decrease in mitochondrial respiration and partially restored the cellular level of NAD+ in ex vivo macrophages harvested from the pleural cavity of rats subjected to carrageenan-induced pleurisy. 5. In conclusion, our study demonstrates that raxofelast, a new hydrophilic vitamin E-like antioxidant agent, exerts multiple protective effects in carrageenan-induced acute inflammation.  (+info)

Reduction of the cardiotoxicity of doxorubicin in rabbits and dogs by encapsulation in long-circulating, pegylated liposomes. (5/728)

The relative cardiotoxicity of pegylated (STEALTH) liposomal doxorubicin (PL-DOX; Doxil) was compared to nonliposomal doxorubicin (Adriamycin) in rabbits and dogs treated i.v. for up to 22 weeks. No histological evidence of cardiotoxicity was seen in dogs treated with placebo liposomes or PL-DOX every 3 weeks for a total of 10 doses (cumulative doxorubicin dose = 10 mg/kg) either 1 or 5 weeks post-treatment. All dogs treated with the same cumulative dose of free doxorubicin showed marked cardiotoxicity (vacuolization and myofibrillar loss in the myocardium) at both time points. In rabbits, progressive cardiomyopathy was seen in both treatment groups, but was more frequent and severe with free doxorubicin (67% of doxorubicin-treated rabbits, cumulative dose = 12 to 14 mg/kg versus 16% of PL-DOX-treated animals, cumulative dose = 14 to 21 mg/kg). Five doxorubicin-treated rabbits died of congestive heart failure or with histologic evidence of cardiotoxicity (median severity score = 6). No PL-DOX-treated rabbits died of congestive heart failure, although two animals that died early showed microscopic evidence of mild cardiotoxicity (median severity score = 2.5). Cardiotoxicity increased during the post-treatment period in both treatment groups. Rabbits received up to 50% more PL-DOX with no increase in cardiotoxicity. Thus, results in two species demonstrate that the cardiotoxicity of doxorubicin is significantly decreased when administered as PL-DOX. Significantly more PL-DOX can be given without incurring an increased risk of cardiomyopathy. Recent clinical studies have confirmed that PL-DOX is also less cardiotoxic than the same dose of unencapsulated doxorubicin in humans.  (+info)

Enhancement of solubilization and biodegradation of polyaromatic hydrocarbons by the bioemulsifier alasan. (6/728)

Alasan, a high-molecular-weight bioemulsifier complex of an anionic polysaccharide and proteins that is produced by Acinetobacter radioresistens KA53 (S. Navon-Venezia, Z. Zosim, A. Gottlieb, R. Legmann, S. Carmeli, E. Z. Ron, and E. Rosenberg, Appl. Environ. Microbiol. 61:3240-3244, 1995), enhanced the aqueous solubility and biodegradation rates of polyaromatic hydrocarbons (PAHs). In the presence of 500 microg of alasan ml-1, the apparent aqueous solubilities of phenanthrene, fluoranthene, and pyrene were increased 6.6-, 25.7-, and 19.8-fold, respectively. Physicochemical characterization of the solubilization activity suggested that alasan solubilizes PAHs by a physical interaction, most likely of a hydrophobic nature, and that this interaction is slowly reversible. Moreover, the increase in apparent aqueous solubility of PAHs does not depend on the conformation of alasan and is not affected by the formation of multimolecular aggregates of alasan above its saturation concentration. The presence of alasan more than doubled the rate of [14C]fluoranthene mineralization and significantly increased the rate of [14C]phenanthrene mineralization by Sphingomonas paucimobilis EPA505. The results suggest that alasan-enhanced solubility of hydrophobic compounds has potential applications in bioremediation.  (+info)

Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. (7/728)

Central sensitization, the hyperexcitability of spinal processing that often accompanies peripheral injury, is a major component of many persistent pain states. Here we report that the neurotrophin, brain-derived neurotrophic factor (BDNF), is a modulator of excitability within the spinal cord and contributes to the mechanism of central sensitization. BDNF, localized in primary sensory neuron cell bodies and central terminals, potentiates nociceptive spinal reflex responses in an in vitro spinal cord preparation and induces c-fos expression in dorsal horn neurons. NMDA receptor-mediated responses, known as a major contributor to central sensitization, were significantly enhanced by exogenous BDNF. Systemic NGF treatment, a procedure that mimics peripheral inflammatory states, raises BDNF levels in sensory neurons and increases nociceptive spinal reflex excitability. This increased central excitability is reduced by trkB-IgG, a BDNF "antagonist." We also show directly that inflammatory pain-related behavior depends on BDNF release in vivo. Thus behavioral nociceptive responses induced by intraplantar formalin and by intraplantar carageenan are significantly attenuated by trkB-IgG. Hence BDNF is appropriately localized and regulated in inflammatory states and is sufficient and necessary for the expression of central sensitization in the spinal cord. We propose that BDNF may function as a modulator of central sensitization in pathological states, and our results suggest that pharmacological antagonism of BDNF may prove an effective and novel analgesic strategy for the treatment of persistent inflammatory pain states.  (+info)

Carrageenan primes leukocytes to enhance lipopolysaccharide-induced tumor necrosis factor alpha production. (8/728)

We have previously reported that pretreatment with carrageenan (CAR) enhances lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha) production in and lethality for mice. Whole blood cultured in vitro was used to show that CAR pretreatment results in about a 200-fold increase in LPS-induced TNF-alpha production. CAR by itself did not induce TNF-alpha production. However, CAR-treated cultured medium sensitized whole blood to make more LPS-induced TNF than did saline-treated cultured medium in vitro. It was also demonstrated that CAR pretreatment increases TNF-alpha mRNA levels of both blood cells and peritoneal exudate cells, but not of bone marrow cells. Immunoelectron microscopic analysis revealed that polymorphonuclear leukocytes and macrophages are TNF-alpha-producing cells in CAR-treated mice. In CAR-treated mice, TNF-alpha was seen early after LPS injection in leukocytes in hepatic sinusoids and on the surfaces of endothelial cells. TNF-alpha was also detected late after LPS injection in hepatocytes which become edematous. These results suggest that CAR primes leukocytes to produce TNF-alpha in response to LPS and that they play an important role in the pathogenesis of liver injury.  (+info)

Although pharmaceutical excipients are considered pharmacologically inert, some excipients in dosage forms have shown an effect on the pharmacokinetics of certain drugs. This could be due to different mechanisms such as opening of tight junctions, inhibition of efflux transporters or interactions with the drug molecules. The presence of P-gp in the different regions of the gastrointestinal tract (GIT) is an important factor that may influence the absorption of drugs. Furthermore, the regions of the gastrointestinal tract have physiological differences that may have an impact on drug absorption, which is the reason why certain drugs have a limited absorption window after oral administration. The aim of this study was to investigate whether selected excipients, Ac-di-sol® (ADS) and Pharmacel® (PC), at different concentrations would have an effect on the transport of the model compound, Rhodamine 123 (Rho123), across excised sections of different regions from the pig gastrointestinal tract (i.e. ...
According to a latest market report published by Persistence Market Research, titled Global Market Study on Pharmaceutical Excipients: Increased Drug Demand in Emerging Asia Pacific Market to Fuel Demand Multi-Functional Excipients, revenue from the global pharmaceutical excipients market is expected to expand at a CAGR of 6.7% during the forecast period 2015 - 2021.. In the report, the global pharmaceutical excipients market is analyzed on the basis of chemistry type (i.e. source of origin), application type, functionality, and region. Based on chemistry type, the overall market has been segmented into plant-based, animal-based, mineral-based and synthetically derived excipients. Based on functionality, the market has been segmented into binders (binders, coatings, and fillers), glidents, diluents, disintegrants, and others (solvents, co-solvents, anti-microbial agents, lubricants, colorants, emulsifiers, and humectants). By application type, the market has been segmented into oral, topical, ...
There is a growing need for research into new skin- and environment-friendly surfactants. The aim of the study was to find out whether a combination of an alkylpolyglucoside natural surfactant with established pharmaceutical excipients could provide a solid pharmaceutical base with satisfied physical stability. The study was carried out in two phases: the first one focused on the colloidal structure of vehicles formulated with oils of different polarity and/or different costabilizer (lipophilic versus hydrophilic) and the second one evaluated vehicles physical stability. A number of techniques were used (polarization, light, and transmission electron microscopy, pH, conductivity and thermogravimetric measurements, rheological analysis and cyclic temperature stress test). Natural surfactants interaction with used excipients resulted in the formation of semisolid emulsion systems of different rheological profiles, stabilized predominantly by synergistic effects of lamellar liquid-cryst...alline ...
TY - JOUR. T1 - The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine. AU - Saito, Shinji. AU - Ainai, Akira. AU - Suzuki, Tadaki. AU - Harada, Norihiro. AU - Ami, Yasushi. AU - Yuki, Yoshikazu. AU - Takeyama, Haruko. AU - Kiyono, Hiroshi. AU - Tsukada, Hideo. AU - Hasegawa, Hideki. N1 - Funding Information: The work described in this report was supported by the grants of the Research Program on Emerging and Re-emerging Infectious Diseases (H25-Shinkou-Ippan-018) from the Japanese Ministry of Health, Labor, and Welfare. PY - 2016/2/24. Y1 - 2016/2/24. N2 - Introduction: Recently, we reported that intranasal vaccination of humans with whole inactivated influenza vaccine in the absence of mucosal adjuvant induced neutralizing antibody responses in the serum and nasal mucus. The mucoadhesive excipient carboxy-vinyl polymer (CVP) increases the viscosity and therefore mucoadhesiveness of intranasal medicaments and is ...
Webinar: Introducing the Co-processed Excipient Guide! Friday, December 15, 2017 - 11:00am to 12:00pm EST Featuring Joseph Zeleznik, Manager of Technical & Regulatory Affairs, Meggle USA, Inc., and Chair, IPEC-Americas QbD Committee Description IPEC-Americas and IPEC Europe have jointly published a guide for excipient makers and users on co-processed excipients. This guide offers best practice and voluntary guidance on the development, manufacture and use of co-processed excipients and provides support to both manufacturers and users of co-processed excipients. Webinar Objectives: ...
In order to develop the enhanced understanding necessary to demonstrate an acceptable Design Space and Control Strategy required for Quality by Design (QbD) marketing applications, it will be necessary to incorporate the variability in potentially critical excipient parameters into the Design of Experiments (DoE). Methods are described that allow samples to be engineered such that potentially critical excipient parameters can be included in the DoE. However, it must be acknowledged that not all such excipient parameters will be amenable to sample engineering. The excipient manufacturer may be able to provide non-GMP samples which help define the necessary limits for the formulation. The nature of QbD as it relates to excipients is such that communication under a confidentiality agreement between excipient users and excipient makers will be necessary. The necessity for good communication between the excipient user and manufacturer is also emphasized.. ...
Global Market Study on Pharmaceutical Excipients: Pharmaceutical excipients are substances other than pharmacologically active drug components, which are included in the drug manufacturing process or contained in a finished pharmaceutical product dosage form.
Data & statistics on Chinese Pharmaceutical Excipients: 1504 310 ความรูพื้นฐานทางเภสัชภัณฑ หนวยกิต 4 (3-3-6) Fundamentals to Pharmaceutical Dosage Forms สาขาเภสัชศาสตร ชั้นปที่ 3 จํานวน 107 คน อ.ดร.จินตนา นภาพร และ อ.ดร.วริษฎา ศิลาออน ทุกวันศุกร เวลา 08.00-16.00 น. ศึ ก ษาความรู พื้ น ฐานทางเภสั ช ภั ณ ฑ ใ นด า นคุ ณ สมบั ติ ท างกายภาพและเคมี (Physicochemical properties) ของสารที่เปนยาและสารชวยทางเภสัชกรรม (Pharmaceutical excipients) กฏทางฟสิกสเคมีและทฤษฎีที่เกี่ยวข
3. Why are excipients important in a drug product?For many reasons. Some, for example, comprise the products delivery system. These transport the active drug to the site in the body where the drug is intended to exert its action. Others will keep the drug from being released too early in the assimilation process in places where it could damage tender tissue and create gastric irritation or stomach upset. Others help the drug to disintegrate into particles small enough to reach the blood stream more quickly and still others protect the products stability so it will be at maximum effectiveness at time of use. In addition, some excipients are used to aid the identification of a drug product. Last, but not least, some excipients are used simply to make the product taste and look better. This improves patient compliance, especially in children. Although technically inactive from a therapeutic sense, pharmaceutical excipients are critical and essential components of a modern drug product. In many ...
The global pharmaceuticals excipients market is projected to post a phenomenal CAGR through 2022. The market is poised to rake in a healthy share of the revenue pie with robust growth of the pharmaceutical industry worldwide. Soaring uptake of oral and parenteral products owing to increasing occurrence of lifestyle and chronic disorders can escalate the growth of the market over the forecast period (2017 to 2022).. Browse Full Research Report With TOC On Pharmaceutical Excipients Market Size, Report, 2017 at: https://www.radiantinsights.com/research/global-pharmaceutical-excipients-market-professional-survey-report-2017. Emergence of novel therapeutics, especially in the form of oral dispersible tablets, is one of the key factors driving the market. Surging use of functional excipients is likely to provide an upthrust to the market. A raft of pharmaceutical companies is focusing on innovations in these excipient categories, which is expected to further bolster their use. Improving R&D ...
Global Active Pharmaceutical Ingredients (API) Market, By Molecule (Small Molecule, Large Molecule), Type (Innovative Active Pharmaceutical Ingredients, Generic Innovative Active Pharmaceutical Ingredients), Type of Manufacturer (Captive API Manufacturer, Merchant API Manufacturer), Synthesis (Synthetic Active Pharmaceutical Ingredients and Biotech Active Pharmaceutical Ingredients), Chemical Synthesis (Acetaminophen, Artemisinin, Saxagliptin, Sodium Chloride, Ibuprofen, Losartan Potassium, Enoxaparin Sodium, Rufinamide, Naproxen, Tamoxifen, Others), Type of Drug (Prescription Drugs, Over-the-Counter), Usage (Clinical, Research), Potency (Low-to-Moderate Potency Active Pharmaceutical Ingredients, Potent-to-Highly Potent Active Pharmaceutical Ingredient), Therapeutic Application (Cardiology, CNS & Neurology, Oncology, Orthopedic, Endocrinology, Pulmonology, Gastroenterology, Nephrology, Ophthalmology, Other Therapeutic Application), Country (U.S., Canada, Mexico, Germany, U.K., France, Italy, Spain,
Alcohol excipients are inactive substances generally used as functional additives in pharmaceuticals. Excipient is inactive substance which is used with the active ingredients to improve absorption in body. Excipients also help to control the release of the active substances over a period of time if the treatment demands. As excipients are added to the formulations that contain active ingredients, they are also called bulking agents, fillers or diluents. They are also used to add flavor, and taste to certain pharmaceuticals.. Planning to lay down strategy for the next few years? Our report can help shape your plan better.. Alcohol excipients are also required to maintain the pH balance of the formulation, in order to optimize chemical stability and anti-microbial effectiveness. Some of the popular alcohol excipients include sorbitol, mannitol, propylene glycol, and glycerin among others. Excipients such as propylene glycol and glycerol are extensively used in aqueous suspensions and emulsions ...
These are just a few examples of many newer multifunctional or high-functioning excipients. Methods used to engineer these products include modification of particle size distribution by milling, seiving, agglomerating, spray drying, or roller compacting; selection of certain crystal polymorphic forms; cocrystallization, isolation of the crystal portion of the cellulose chain; modifications of the cooking process; modifications of the drying process; and nanosize water dispersion.2 Using multifunctional excipients simplifies the formulation process. Cost savings are not necessarily realized in reducing the amount of excipient used, which is a very small fraction of the cost of the tablet, but in reducing the total number of ingredients. Simple formulations are more straightforward to prepare, and fewer ingredients reduce the odds of adverse drug-excipient or excipient-excipient interactions. Multifunctional excipients are especially valuable in the manufacture of generic drugs, where there are ...
A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.
SHREEJI PHARMA from Gujarat, India is a manufacturer, wholesaler, supplier of top quality pharmaceutical excipients at the best price.
Excipients are used in most drug products and the quality of the materials, manufacturing processes, and test methods are vital to the production of safe, effective therapies. While industry guidances, excipient monographs, and compendial test methods provide some direction, sourcing and testing of excipients is an ongoing challenge for drug manufacturers.. A complex supply chain, raw materials quality concerns, and lot-to-lot and supplier-to-supplier variability are just some of the factors that can affect the consistency of excipient quality and performance. Routine testing of excipients, therefore, is crucial. Drug manufacturers must not only verify compendial test methods, but also assess the suitability of these test methods to meet the requirements of excipients, manufacturing processes, and analytical instruments currently used.. In this webcast, experts will review measures drug manufacturers must take to comply with regulatory requirements; outline best practices for selecting and ...
The aim of study was for the development of any formulation, techniques such as thermal and isothermal stress testing were used to assess the compatibility of drug with excipients. Differential scanning calorimetry (DSC) and Fourier transformation infrared spectroscopy (FTIR) were the common methods for the study of compatibility. Isothermal stress testing (IST) is also a method for the compatibility study during proto type formulation. In the present study drug excipients compatibility study of gatifloxacin was conducted with different controlled release excipients. The drug and excipients mixtures were stored at 50°C for 4 weeks. The samples were then characterized using DSC, FTIR and UV spectrophotometric methods. The results show that gatifloxacin was compatible with the all the excipients used in the study. The excipients used in the present study were definitely incorporated in the extended release gatifloxacin formulation.
Manufacturer of Cellulose Derivatives and Excipients, Microcrystalline Cellulose, Sodium Starch Glycolate, Croscarmellose Sodium, Spirulina, Magnesium Stearate Etc.
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As biotherapeutics are usually delivered by injection at relatively high concentrations, formulation viscosity is critically important, and a variety of small molecule excipients may be used to reduce viscosity by inhibiting protein aggregation, said Dr Leszczyszyn. Having the ability to screen formulations for viscosity issues or against a particular viscosity threshold at an early stage of development when sample volumes are limited, using a system such as the Viscosizer 200, will facilitate and expedite candidate selection and contribute to quicker, more cost-effective routes to market ...
For a detailed understanding of the market, the excipients market has been divided into overall excipients and oral solid-dosage-form (OSDF) The report comprises a detailed analysis and forecast of the excipients market on a global as well as regional level. On a global level, the forecast demand is based on volume (tons) and revenue (USD million) for the period ranging from 2012 to 2018. For an insightful understanding of the market on a regional level, the demand has been forecasted based on volume (tons) and revenue (USD million). The study consists of drivers and restraints of the excipients market and their impact on the growth of the market over the forecast period. In addition, the study takes into account opportunities available on a global and regional level and its effect on the market over the forecast period ...
The global excipients market size is expected to reach USD 6.9 billion by 2025, expanding at a CAGR of 6.02% from 2017 to 2025, according to a new report by Grand View Research, Inc. Globally increasing reach of generic medicines has been a major factor driving market growth. In addition, rising demand for newer excipients owing to the advantages of drug delivery and stability has led to the growth of the market. Excipients are essential components for the improvement of overall pharmaceutical activity and performance, both of which directly impact the characteristics of pharmaceutical formulations. An excipient in the right proportion can improve the shelf life and bioavailability of a formulation. These can also be used in drug delivery mechanisms such as sustained release and rapid release drugs.. Polymers were the largest product category in 2016 and are expected to maintain a comparatively moderate growth rate over the forecast period. Microcrystalline cellulose was the leading polymer in ...
An excipient is an inactive substance formulated alongside the active ingredient (API) of a medication, for the purpose of bulking-up formulations that contain potent active ingredients (thus often referred to as bulking agents, fillers, or diluents). Bulking up allows convenient and accurate dispensation of a drug substance when producing a dosage form. They also can serve various therapeutic-enhancing purposes, such as facilitating drug absorption or solubility, or other pharmacokinetic considerations.[1] Excipients can also be useful in the manufacturing process, to aid in the handling of the active substance concerned such as by facilitating powder flowability or non-stick properties, in addition to aidingin vitro stability such as prevention of denaturation over the expected shelf life. The selection of appropriate excipients also depends upon the route of administration and the dosage form, as well as the active ingredient and other factors. http://en.wikipedia.org/wiki/Excipient ...
Market Research Reports : Transparency Market Research published new market report Oral Solid Dosage Forms (OSDF) and Pharma Excipients Market for Polymers (MCC, HPMC, CMC, Ethyl Cellulose, Povidone and Others), Alcohols (Glycerin, Sorbitol, Mannitol, Propylene Glycol), Minerals (Clay, Silicon Dioxide, Titanium Dioxide) and Sugars (Lactose, Sucrose) - Global Industry Analysis, Size, Share, Trends, Analysis, Growth and Forecast, 2012 - 2018, the global OSDF excipients demand was 93.8 kilo tons in 2011 and is expected to reach 126.8 kilo tons in 2018, growing at a CAGR of 4.5% from 2012 to 2018. In terms of revenue, the market was valued at USD 570.6 million in 2011 and is expected to reach USD 869.1 million in 2018, growing at a CAGR of 6.3% from 2012 to 2018. The overall pharmaceutical excipients demand was 519.5 kilo tons in 2011 and is expected to reach 685.6 kilo tons in 2018, growing at a CAGR of 4.1% from 2012 to 2018. ...
Phospholipids have gained importance as formulation excipients due to their physicochemical diversity, biocompatibility, and capacity to enhance oral bioavailability of poorly water-soluble drugs.1)2) The main techniques for transforming liquid or semi-solid lipid formulations into solid-based particles or granules are spray-cooling, spray-drying, adsorption onto solid carriers, melt granulation, melt extrusion, supercritical fluid-based methods and high pressure homogenization.3) However, few studies have evaluated conventional dosage forms such as tablets containing phospholipids. Studies on incorporation of phospholipids into solid oral dosage forms such as tablets and pellets are rare.. Tableting involves several energy intensive processes, which could be a challenge for processing of phospholipids due to their waxy nature. Furthermore, powder properties such as the flowability and density of phospholipids and their blends with common excipients are important factors for their potential ...
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Mannitol is a pharmaceutical excipient that is receiving increased popularity in solid dosage forms. This study contributes to the development of mannitol as a potential excipient of the first choice.
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A free-flowing directly compressible granulation useful as a slow release pharmaceutical excipient is disclosed. The excipient includes a hydrodrophilic matrix which includes a heteropolysaccharide and a polysaccharide material capable of cross-linking the heteropolysaccharide, and an inert diluent.
A free-flowing directly compressible granulation useful as a slow release pharmaceutical excipient is disclosed. The excipient includes a hydrodrophilic matrix which includes a heteropolysaccharide and a polysaccharide material capable of cross-linking the heteropolysaccharide, and an inert diluent.
The global excipients market is anticipated to reach USD 5.22 billion by 2020, growing at a CAGR of 6.0% from 2014 to 2020, according to a new report by Grand View Research, Inc. Growing developments in the field of medicine formulation and rise in research in the field of dosage technology are expected to drive this industry through the forecast period. Introduction of novel technologies for utilization of generic drugs in the development of new formulations is expected to boost growth of this industry over the forecast period. Furthermore, increasing global geriatric population base is anticipated to significantly raise demand for pharmaceuticals as this segment of the population is prone to high risk of organ disorders and infections, thereby propelling market growth.. Full research report on excipients market analysis: http://www.grandviewresearch.com/industry-analysis/excipients-market-analysis. Increasing demand for diverse excipients pertaining to interaction with active pharmaceutical ...
The global excipients market is anticipated to reach USD 5.22 billion by 2020, growing at a CAGR of 6.0% from 2014 to 2020, according to a new report by Grand View Research, Inc. Growing developments in the field of medicine formulation and rise in research in the field of dosage technology are expected to drive this industry through the forecast period. Introduction of novel technologies for utilization of generic drugs in the development of new formulations is expected to boost growth of this industry over the forecast period. Furthermore, increasing global geriatric population base is anticipated to significantly raise demand for pharmaceuticals as this segment of the population is prone to high risk of organ disorders and infections, thereby propelling market growth.. Full research report on excipients market analysis: http://www.grandviewresearch.com/industry-analysis/excipients-market-analysis. Increasing demand for diverse excipients pertaining to interaction with active pharmaceutical ...
The processibility of 15 carbohydrates, more or less commonly used, was investigated as excipients in supercritical fluid drying. The focus was on the ability to produce amorphous powder, the stability of the powders towards crystallisation, and the residual water and ethanol content. The aqueous solutions were sprayed into a pressurised carbon dioxide-ethanol mixture flowing cocurrently through a coaxial two-fluid nozzle. The powder characteristics appeared to be influenced by the supersaturation level reached during the SCF-drying process and by the properties of the sugar species, such as water solubility and glass transition temperature, or the solution viscosities. The stability and the residual solvent content of a selected set of sugars and some mixtures were further analysed. The stability of amorphous powders was investigated at 4 degrees C, room temperature, 40 and 50 degrees C. Lactose, maltose, trehalose, raffinose, cyclodextrin, low-molecular-weight dextran and inulin could form ...
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Excipients in Pharmaceuticals Excipients in Pharmaceuticals The global excipients market should reach nearly $6.9 billion by 2020 from approximately $6.3 billion in - Market research report and industry analysis - 10039728
Granulocyte-colony stimulating factor (G-CSF) is a cytokine which is therapeutically used in oncology and hematology. It tends to form soluble and insoluble aggregates particularly under high-stress conditions that occur during the pharmaceutical production process. Aggregates of therapeutic proteins can cause severe adverse reactions after administration, but they also reduce shelf life and pharmacological activity. Prevention of protein aggregation in drug formulations is of considerable importance in pharmaceutical industry. Therefore high effort for optimization of formulations is necessary to obtain an optimum of protein stability. Knowledge about the mechanism and the process kinetics of G-CSF aggregation could enable the improvement of algorithms for the prediction of protein aggregation and lead to cost reduction of formulation development. The simulation of process conditions was accomplished by agitation and exposure of G-CSF to gas-liquid interfaces. Size exclusion HPLC was employed ...
The internal pore structure of chars derived from many bituminous and sub-bituminous coals can be best described by bi-modal pore size distribution. Their macropores, which account for nearly all the porosity, are interconnected spherical cavities with diameters as large 100 or 200 microns for 500--750 micron particles. Most of the internal surface area of these chars, however, is associated with micropores that are usually smaller than 30 A. In order to elucidate the effect of process conditions on the internal pore structure of coal-derived char particles and ultimately their overall reactivities, staged and sequential combustion algorithms are designed using thermogravimetric reactor equipped with in-situ video microscopy imaging (TGA/VMI). Our experiments showed that coal-derived char particles treated with higher pyrolysis heating rates have more open macropore structure than those treated with lower heating rates. At low combustion temperature where the reaction was kinetic controlled, the ...
The focus of this thesis was to evaluate the impact of mechanical activation (milling and dry mixing) and spray drying on the crystallinity of selected active pharmaceutical ingredients (APIs) and to explore the feasibility of co-processing these drugs with low glass transition temperature (Tg) excipients as a strategy for preventing process induced amorphisation. Co-milling investigations were initially performed on sulfadimidine and salbutamol sulphate. Based on the data obtained for these two APIs, further analysis was conducted on budesonide to see if results could be generalised to other compounds. Co-spray drying experiments were performed with sulfadimidine as API. The excipients chosen were dicarboxylic acids (glutaric, adipic, succinic, pimelic and malic acid) and sugar alcohols (mannitol and xylitol ...
Chemical APIs (Active Pharmaceutical Ingredients) Spectrum Chemical manufactures and distributes over 400 chemical APIs (active pharmaceutical ingredients. These substances are the biologically active component of any drug product regardless of pharmaceutical formulation type (tablets, capsules, topical, etc.). Spectru
(EMAILWIRE.COM, December 14, 2017 ) Europe Sugar based Excipients Market was worth USD 301.21 million in 2016 and estimated to be growing at a CAGR of 4.1%, to reach USD 368.23 million by 2021. A certain formulation contains both an active pharmaceutical ingredient and an excipient. It is mainly...
Author: Geiger Christine M, Sorenson Bridget, Whaley Paul, Year: 2015, Abstract: The stability of 10 active pharmaceutical ingredients was studied in SyrSpend SF PH4 or SyrSpend SF Alka at room and/or refrigerated temperature (2°C to 8°C). An oral suspension of each active pharmaceutical ingredient was compounded in low actinic plastic bottles at a specific concentration in SyrSpend SF PH4 or SyrSpend SF Alka. Samples were assessed for stability immediately after preparation (day 0) followed by storage at room temperature and/or at refrigerated temperature. At set time point
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Further key findings from the report suggest:. • Crucial companies are, gradually more, concentrating on the vaccines; for example, Sanofi declared the investment of USD 601.37 million, for the research activities and the manufacturing of the vaccine in France. These funds are expected to impel the growth of novel vaccine active pharmaceutical ingredients, during the upcoming years, to assist in supply innovative products. • Consistent with the Centers for Disease Control and Prevention (CDC), roughly 795,000 people in the U.S., experience stroke each year. 87% of these cases are of ischemic stroke. • As per the information by World Health Organization (WHO), approximately, 17.5 million populace, expires every year, owing to the cardiovascular sickness, which is responsible for the 31% of the entire deaths, through the world. • The manufacturing companies require branching out their active pharmaceutical ingredients providers, to diverse places, rather than outsourcing it to merely one ...
Product Description Antidiabetic Active Pharmaceutical Ingredients Nateglinide CAS 105816-04-4 Product Name: Nateglinide Synonyms: (-)-n-(trans-4-isopropylcyclohexanecarbonyl)-d-phenylalanine;ay4166;Nateglinide(H);trans-d-phenylalanin;trans-n-((4-(1-methylethyl)cyclohexyl)carbonyl)-d-phenylalanine;3-phenyl-2-(4-propan-2-ylcyclohexyl)carbonylamino-propanoic acid;A-4166;STARLIX CAS: 105816-04-4 MF: C19H27NO3 MW: 317.42 Product Categories: Active Pharmaceutical Ingredients;API;APIs;Health & Beauty;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;STARLIX;Antidiabetic Melting point : 137-141°C Storage temp. : Room temp Chemical Properties : White Cyrstalline Solid Usage : antidiabetic KATP channel blocker…
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(EMAILWIRE.COM, November 24, 2017 ) In this report, the global Active Pharmaceutical Ingredients market is valued at USD XX million in 2017 and is projected to reach USD XX million by the end of 2021, growing at a CAGR of XX% during the period 2017 to 2021. Active Pharmaceutical Ingredients...
Pharmaceutical Technology has released an eBook called Solid Dosage and Excipients. The examines how advances in technology, equipment, excipients, analytical techniques, software, and manufacturing practices are facilitating the development, scale up, manufacturing, efficacy, and delivery of solid- and semi-solid dosage forms ...
Tablets are not only made of active pharmaceutical ingredients (API) but also of excipients which improve the powder processing and the quality of the final dosage form. Tableting is a multiple step process whose success depends on the parameters of instruments used and powder handling. Granulation and drying, in particular, require a suitable combination of excipients. This application report investigates the moisture uptake capacity of the excipients milled and sieved lactose as well as methylcellulose in order to estimate their behavior during wet granulation. The same excipients were also tested at different temperatures to reproduce the drying effect of a fluidized bed dryer. It was found that the amount of moisture adsorbed during wet granulation and the consecutive temperature effect during drying have an impact on the flow and compression characteristics. Read more ...
Natural polysaccharides are drawing a great deal of attention in the recent years as excipient in the pharmaceutical industry. Due to the advances in drug delivery technology, natural polysaccharides are included in controlled drug delivery to fulfill multitask functions and in some cases directly or indirectly influence the extent and /or rate of drug release. In the present study, the polysaccharides extracted from Terminalia belarica gum (TBG) were evaluated for its safety and potency towards pre formulation studies as a pharmaceutical excipient. The study was undertaken with an objective to expound the physicochemical, thermal and functional properties of polysaccharide obtained from Terminalia belarica gum (TBG). A purified component of polysaccharide was isolated from Terminalia belarica gum (TBG) by gel filtration method. Elemental analysis, Scanning electron microscopy (SEM), X-ray diffraction spectroscopy (XRD), Differential scanning microscopy (DSC) and Fourier-transformed infrared ...
Market study report Global Solubility Enhancement Excipients for OSDF Market Insights Report 2019-2025 : BASF, Dow Chemical, Evonik, Shin-Etsu Chemicald Global Solubility Enhancement Excipients for OSDF Market 2019 Industry Research Report recently published on e-marketresearch.com is the key document for industries/clients to understand current global competitive market status. The Solubility Enhancement Excipients for OSDF market study report base year is 2018 and provides market research data status (2013-2017) and forecast (2019-2025) and also categorizes the Solubility Enhancement Excipients for OSDF market into key industries, region, type and application. Global Solubility Enhancement Excipients for OSDF Market 2019 study report covers all major geographical regions and sub-regions in the world and concentrates on product sales, value, market size and growth opportunities in these regions.. Competitive Analysis for Solubility Enhancement Excipients for OSDF market industries/clients :- ...
Cellulose acetate phthalate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 (HIV-1) and several herpesviruses. CAP formulations inactivated HIV-1, herpesvirus types 1 (HSV-1) and 2 (HSV-2) and the major nonviral sexually transmitted disease (STD) pathogens and were effective in animal models for vaginal infection by HSV-2 and simian immunodeficiency virus. Enzyme-linked immunoassays and flow cytometry were used to demonstrate CAP binding to HIV-1 and to define the binding site on the virus envelope. 1) CAP binds to HIV-1 virus particles and to the envelope glycoprotein gp120; 2) this leads to blockade of the gp120 V3 loop and other gp120 sites resulting in diminished reactivity with HIV-1 coreceptors CXCR4 and CCR5; 3) CAP binding to HIV-1 virions impairs their infectivity; 4) these findings apply to both HIV-1 IIIB, an X4 virus, and HIV-1 BaL, an R5 virus. These results provide support for
Press Release issued Jul 18, 2017: Taste masking techniques are applied to overcome or mask the unpleasant and bitter taste of active pharmaceutical ingredients to achieve patient acceptability and compliance. Oral administration of bitter and unpleasant tasting drugs is often the biggest challenge for pediatric and geriatric patient groups. Unless the active ingredient is tasteless or does not have any unpleasant taste, taste-masking plays a key role in the success of a final solid oral dosage form. The efficiency of taste-masking is often a key determinant for the success of specialized dosage forms like orally disintegrating tablets and films, and chewable tablets. The mechanisms of taste-masking techniques often rely on two major approaches the first is to add excipients like sweeteners, flavors, and effervescent agents to mask the unpleasant taste, and the second is to avoid the contact of bitter and unpleasant drugs with taste buds.
ALBANY, New York, November 7, 2012 /PRNewswire/ --. According to a new market report published by Transparency Market Research (http://www.transparencymarketresearch.com) Excipients Market - Global Industry Analysis, Market Size, Share, Trends, Analysis, Growth and Forecast, 2012 - 2018, the global excipients demand was worth USD 5,260.0 million in 2011 and is expected to reach USD 7,586.6 million in 2018, growing at a CAGR of 5.4% from 2013 to 2018. Currently, Europe dominates the global market in terms of demand; however Asia Pacific is expected to be the most promising market in the near future mainly due to the availability of low cost products and cheap labor. The North America market for excipients in terms of revenue is growing at a CAGR of 5.3% from 2013 to 2018 as the U.S. has the biggest pharmaceutical market globally.. Browse the full report at http://www.transparencymarketresearch.com/excipients-market.html. The demand for excipients is witnessing significant growth as it is ...
According to a new market report published by Transparency Market Research Excipients Market - Global Industry Analysis, Market Size, Share, Trends, Analysis, Growth and Forecast, 2012 - 2018, the global excipients demand was worth USD 5,260.0 million in 2011 and is expected to reach USD 7,586.6 million in 2018, growing at a CAGR of 5.4% from 2013 to 2018. Currently, Europe dominates the global market in terms of demand; however Asia Pacific is expected to be the most promising market in the near future mainly due to the availability of low cost products and cheap labor. The North America market for excipients in terms of revenue is growing at a CAGR of 5.3% from 2013 to 2018 as the U.S. has the biggest pharmaceutical market globally ...
Marwaha, S.S.; Kennedy, J.F.; Sehgal, V.K., 1988: Simulation of process conditions of continuous ethanol fermentation of whey permeate using alginate entrapped Kluyveromyces marxianus NCYC 179 cells in a packed-bed reactor system
Contamination of bacteria in large-scale yeast fermentations is a serious problem and a threat to the development of successful biofuel production plants. Huge research efforts have been spent in order to solve this problem, but additional ways must still be found to keep bacterial contaminants from thriving in these environments. The aim of this project was to develop process conditions that would inhibit bacterial growth while giving yeast a competitive advantage. Lactic acid bacteria are usually considered to be the most common contaminants in industrial yeast fermentations. Our observations support this view but also suggest that acetic acid bacteria, although not so numerous, could be a much more problematic obstacle to overcome. Acetic acid bacteria showed a capacity to drastically reduce the viability of yeast. In addition, they consumed the previously formed ethanol. Lactic acid bacteria did not show this detrimental effect on yeast viability. It was possible to combat both types of bacteria by
Given the growing interest in the production of new and low cost bioemulsifiers, the rice and wheat bran and straw were investigated in this study for the production of bioemulsifier by Lactobacillus plantarum subsp. plantarum PTCC 1896 (probiotic). The strain produced bioemulsifier only in the rice bran hydrolysate medium. The bioemulsifier amount reached around 0.7 g L-1 for 72 hours of fermentation. The new biomolecule was extracted, purified, and its structural and thermal properties were evaluated. The functional groups and the structure of the molecule were revealed by GPC, FT-IR, 1HNMR and 13CNMR techniques. The bioemulsifier was a water soluble extracellular high molecular weight (|107 Da) α-glucan (81.74%) bound with protein (18.18%). Thermal behavior was studied using DSC and TG analysis. Thermal analysis showed the bioemulsifier broke down above 211.74°C, and the melting point was 182.0°C with the enthalpy value of 101.7 J g-1. These results might provide incentives for the industrial
Given the growing interest in the production of new and low cost bioemulsifiers, the rice and wheat bran and straw were investigated in this study for the production of bioemulsifier by Lactobacillus plantarum subsp. plantarum PTCC 1896 (probiotic). The strain produced bioemulsifier only in the rice bran hydrolysate medium. The bioemulsifier amount reached around 0.7 g L-1 for 72 hours of fermentation. The new biomolecule was extracted, purified, and its structural and thermal properties were evaluated. The functional groups and the structure of the molecule were revealed by GPC, FT-IR, 1HNMR and 13CNMR techniques. The bioemulsifier was a water soluble extracellular high molecular weight (|107 Da) α-glucan (81.74%) bound with protein (18.18%). Thermal behavior was studied using DSC and TG analysis. Thermal analysis showed the bioemulsifier broke down above 211.74°C, and the melting point was 182.0°C with the enthalpy value of 101.7 J g-1. These results might provide incentives for the industrial
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The effect of the Active Pharmaceutical Ingredient (API) particle size on the dissolution rate in the polymer excipient during hot melt extrusion is investigated using a co-rotating twin-screw extruder with three different screw configurations. Acetaminophen (APAP) and amphiphilic polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PVCap-PVAc-PEG) (Soluplus) are chosen as the model API and water- soluble polymer excipient, respectively. APAP is milled using a fluid energy mill (FEM) into two different particle sizes. The thermal properties of processed samples are characterized by TGA and DSC. SEM and optical microscopy are also used in the morphological studies. Under quiescent conditions, API particles with small particle size dissolve faster than the large ones. During the extrusion process using a co-rotating twin- screw extruder, fully-filled kneading blocks perform well in dissolving the API into the polymeric excipient matrices for both of APIs particle sizes. However,
Selection of Optimal Hot Extrusion Process Parameters for AA6061-Fly Ash Composites: Using Simulation: 10.4018/IJMFMP.2018010104: The simulation of hot extrusion process is a challenging problem in process modeling because of very large deformations, strain rates and temperature changes
Driven by the rising demand for low-fat foods and the robust expansion of the global pharmaceutical excipient industry, the global microcrystalline cellulose market is expected to exhibit moderate growth over the period between 2014 and 2020. The report, titled Microcrystalline Cellulose Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020, states that the market will expand at a 5.80% CAGR over the reports forecast period and rise from a valuation of US$632.9 mn in 2013 to US$936.3 mn by 2020 ...
A therapeutic deep eutectic system (THEDES) is here defined as a deep eutectic solvent (DES) having an active pharmaceutical ingredient (API) as one of the components. In this work, THEDESs are proposed as enhanced transporters and delivery vehicles for bioactive molecules. THEDESs based on choline chloride (ChCl) or menthol conjugated with three different APIs, namely acetylsalicylic acid (AA), benzoic acid (BA) and phenylacetic acid (PA), were synthesized and characterized for thermal behaviour, structural features, dissolution rate and antibacterial activity. Differential scanning calorimetry and polarized optical microscopy showed that ChCl:PA (1:1), ChCl:AA (1:1), menthol:AA (3:1), menthol:BA (3:1), menthol:PA (2:1) and menthol:PA (3:1) were liquid at room temperature. Dissolution studies in PBS led to increased dissolution rates for the APIs when in the form of THEDES, compared to the API alone. The increase in dissolution rate was particularly noticeable for menthol-based THEDES. ...
TY - JOUR. T1 - The role of solid state characterization in predicting stability of solid dosage forms. AU - Szabó, Péter. AU - Zelkó, Romána. AU - Antal, István. PY - 2016/9/1. Y1 - 2016/9/1. N2 - Stability of a dosage form is its ability to preserve its quality attributes within preset limits. The time span over which these attributes remain within specifications is the shelf-life of the drug product. Stability is a very complex feature and is influenced not only by the stability of the drug substance but also by the stability of excipients and the interaction of the components within the system. Another important contributing factor is the packaging material, which is responsible for the protection of the drug product. Not only drug substances, but also excipients are susceptible to different degradation mechanisms. Amorphous polymers, a relatively frequently used group of excipients, are especially prone to physical instability. Through the process of physical ageing, a slow volume and ...
As all the three extruders are running at similar speeds, the end product is developed with minimal handling. A negative point of this process is the amount of production loss occurred, in case any of the three extruders is not running efficiently or there is some problem with only one of the extruders.. Wire coating is generally done by the use of single screw extruders, in which the crosshead extrusion process is carried out. The job of the extruder is to melt the resin & forward it to the die at an even & constant melt pressure and temperature. The crosshead extrusion process is carried out by using a general equipment in the line, which includes following basic pieces:. ...
Various techniques for physical characterization of active pharmaceutical ingredients, including X-ray powder diffraction, birefringence observation, Raman spectroscopy, and high-performance liquid chromatography, can be conducted using 96-well plates. to indicate the heat. The model medicines used were indomethacin (melting heat, 160C), mannitol (166C), carbamazepine (174C, … Emissivity of the samples is required to calculate absolute temps. That of the pharmaceutical powders was about 0.86 in most cases, and this value can be used at least for the testing purposes. Figure?5 shows the surface temps of indomethacin and carbamazepine determined using the infrared camera. In the case of indomethacin, before melting, the surface temperature of the samples improved at a heating rate identical to that of the sample plate, even though heat itself was lower than that of the surrounding plate. This was followed by a drastic increase in the sample temperature, caused by an increase in the thermal ...
Particle size effect on the performance of Active Pharmaceutical Ingredient,Technical Articles,Technology,Jinan Winner Particle Instruments Joint Stock Co. Ltd.,1) API market conditionoverview:the pharmaceutical industry is divided into the pharmaceu
Particle size effect on the performance of Active Pharmaceutical Ingredient,Technical Articles,Technology,Jinan Winner Particle Instruments Joint Stock Co. Ltd.,1) API market conditionoverview:the pharmaceutical industry is divided into the pharmaceu
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Abstract. Thermal shift assays measure the stability of macromolecules and macromolecular assemblies as a function of temperature. The Particle Stability Thermal Release Assay (PaSTRy) of picornaviruses is based on probes becoming strongly fluorescent upon binding to hydrophobic patches of the protein capsid (e.g., SYPRO Orange) or to the viral RNA genome (e.g., SYTO-82) that become exposed upon heating virus particles. PaSTRy has been exploited for studying the stability of viral mutants, viral uncoating, and the effect of capsid-stabilizing compounds. While the results were usually robust, the thermal shift assay with SYPRO Orange is sensitive to surfactants and EDTA and failed at least to correctly report the effect of excipients on an inactivated poliovirus 3 vaccine. Furthermore, interactions between the probe and capsid-binding antivirals as well as mutual competition for binding sites cannot be excluded. To overcome these caveats, we assessed differential scanning fluorimetry with a ...
ACTIVE PHARMACEUTICAL INGREDIENTS (API) , Wholesale active pharmaceuticals ingredients manufacturer,(API), Indian Manufacture, Indian Exporter, Indian Wholesaler, Indian Supplier, Indian Product
Exporter of Active Pharmaceutical Ingredients - Ammonium Chloride Pure, Tannic Acid Powder, Silver Nitrate and Aluminium Sulphate Powder offered by S. V. Enterprises, Mumbai, Maharashtra.
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The Report Active Pharmaceutical Ingredients (API) Market in the Americas to 2017 - Shift Towards Generics and Biosimilars as South and Central America Emerges as a Key Growth Region provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports.biz
V & V Pharma Industries, Exporter & Manufacturer Of Active Pharmaceutical Ingredients, APIs, Pharmaceutical Intermediates, Ninhydrin, Quinoline, Specialty Chemicals, Mumbai, India
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[108 Pages Report] Check for Discount on United States High Potency Active Pharmaceutical Ingredients (HPAPI) Market Report 2017 report by QYResearch Group. In this report, the United States High Potency Active Pharmaceutical...
A comprehensive guide to side effects including common and rare side effects when taking Accupril (Quinapril Hydrochloride) includes uses, warnings, and drug interactions.
Accupril (quinapril hydrochloride) is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure (hypertension) and heart failure.
A collection of nanoscale particles are a composite of carbon and metal oxide or silicon oxide. The composite particles have an average diameter from about 5 nm to about 1000 nm, and can be produced by laser pyrolysis. The laser pyrolysis involves the formation of a molecular stream including a metal precursor, an infrared absorber, an oxidizing agent and a carbon precursor. The pyrolysis is driven by heat absorbed from a laser beam. Furthermore, nanoparticles including titanium oxide with a rutile crystal structure have been produced.
0046] Pore formers 240 can be included in the mixture to enhance the pore space 120 of the bioactive scaffold 100. Pore formers are non-reactive materials that occupy volume in the plastic batch material during the mixing step 260 and the forming step 270. When used, the particle size and size distribution of the pore former 240 will influence the resulting pore size and pore size distribution of the pore space 120 of the scaffold 100. Particle sizes can typically range between about 25 μm or less to about 450 μm or more, or alternatively, the particle size for the pore former can be a function of the fibers 210 diameter ranging from about 0.1 to about 100 times the diameter of the fibers 210. The pore former 240 must be readily removable during the curing step 280 without significantly disrupting the relative position of the surrounding fibers 210. In an embodiment of the invention, the pore former 240 can be removed via pyrolysis or thermal degradation, or volatilization at elevated ...
The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubility of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2.
We are an ISO 9001:2008 Certified Company Manufacturer, Supplier and Exporter of Excipients For Pharma And Cosmetic Cream based in Vadodara, Gujarat, India.
Founded in 1986, Signet Chemical Corporation Pvt. Ltd. is a pioneer in the excipients business in India.Since its inception, Signet has combined technical expertise with commercial support to provide its clients accurate information and exceptional product value. With 90 qualified and well-trained members, the Signet team has an excellent understanding of the intricacies of the market and has strong relationships with key partners to take the company forward.At Signet, the numbers speak for themselves.
The Isotope-Labeled Excipients Market report provides in-depth analysis of parent market trends, macro-economic indicators and governing factors along with
Arginine was produced via fermentation of sugars using the engineered microorganism Escherichia coli. Zeolite-Y adsorbents in the form of powder and extrudates were used to recover arginine from both a real fermentation broth and aqueous model solutions. An adsorption isotherm was determined using model solutions and zeolite-Y powder. The saturation loading was determined to be 0.2 g/g using the Sips model. Arginine adsorbed from a real fermentation broth using either zeolite-Y powder or extrudates both showed a maximum loading of 0.15 g/g at pH 11. This adsorbed loading is very close to the corresponding value obtained from the model solution showing that under the experimental conditions the presence of additional components in the broth did not have a significant effect on the adsorption of arginine. Furthermore, a breakthrough curve was determined for extrudates using a 1 wt % arginine model solution. The selectivity for arginine over ammonia and alanine from the real fermentation broth at ...
MgSO4.7H2O 0.730 g/l) obtained by a Plackett-Burman Therefore, the objective of this research was to produce design and RSM were added, and the pH of the medium the finest-quality rice-based nutraceutical-containing maxi- was adjusted as per the experimental design with 0.1 M mum amount of a hypocholestromic agent (lovastatin). Two HCl or NaOH and autoclaved for 20 min at 121 °C. After filamentous fungi, M. purpureus MTCC 369 and M. ruber being cooled, the rice-based medium was inoculated with MTCC 1880, were used together as inocula for the mixed seed cultures of M. purpureus and M. ruber. Box- production of the nutraceutical under solid-state fermenta- Behnken response surface design (Sayyad et al. was tion. As the fermentation process is highly regulated by followed to design fermentation process conditions such as different fermentation process conditions, interactions of temperature, fermentation time, inoculum volume, and pH parameters and their optimum levels were determined by of the ...
There are multiple factors that drive glycosylation and several currently available approaches to influence glycosylation patterns. Notable factors that influence glycosylation include the following: cell culture process conditions, ingredients in cell culture, genetic selection or engineering, and directly impacting the physiological organelles responsible for glycosylation (endoplasmic reticulum - the ER - and Golgi apparatus). In cell line development there are opportunities to use genetic engineering tools to manipulate the glycosylation pathway. In upstream development, cell culture process conditions (ie. temperature and pH) can be manipulated. Lastly, commercially available constituents in the glycan process, such as precursors and enzymes, can be added to cell culture media to further hone glycoprofiles. However, there have been limited available approaches to improve the functionality of the ER and Golgi.. One relatively unexplored lever to improve ER and Golgi functionality, and thus ...
Shin-Etsu Chemical has been producing various cellulose derivatives. METOLOSE® is used for industrial (construction, personal care etc.) and food products. Others used as pharmaceutical excipients, such as coating agents and disintegrants.
Get Sample PDF of report at @ http://www.360marketupdates.com/enquiry/request-sample/10311263 After the basic information, the report sheds light on the production. Production plants, their capacities, global production and revenue are studied. Also, the Microcrystalline Cellulose(MCC) Market growth in various regions and R&D status are also covered.. Further in the report, the Microcrystalline Cellulose(MCC) Market is examined for price, cost and gross. These three points are analysed for types, companies and regions. In continuation with this data sale price is for various types, applications and region is also included. The Microcrystalline Cellulose(MCC) Industry consumption for major regions is given. Additionally, type wise and application wise consumption figures are also given.. Analysis also include consumption. Import and export data for Regions North America, Europe, China, Japan, Southeast Asia, India.. Purchase this report @ http://www.360marketupdates.com/purchase/10311263 With the ...
The effects of different formulations and manufacturing process conditions on the physical properties of a solid dosage form are of importance to the pharmaceutical industry. It is vital to have in-depth understanding of the material properties and governing parameters of its processes in response to different formulations. Understanding the mentioned aspects will allow tighter control of the process, leading to implementation of quality-by-design (QbD) practices. Computational intelligence (CI) offers an opportunity to create empirical models that can be used to describe the system and predict future outcomes in silico. CI models can help explore the behavior of input parameters, unlocking deeper understanding of the system. This research endeavor presents CI models to predict the porosity of tablets created by roll-compacted binary mixtures, which were milled and compacted under systematically varying conditions. CI models were created using tree-based methods, artificial neural networks ...
Ideally, the antibiotic would only act locally in the mouth rather than throughout the entire body. Mäders research group has therefore combined a proven antibiotic (minocycline) with an equally proven pharmaceutical excipient (magnesium stearate). The complex is just as effective, but more stable. It slowly releases the antibiotic on the spot, explains Mäder. In addition to the continuous and sustained release of the antibiotic, we needed to find an easy way of administering it. His research group found a practical solution to this problem by utilising pharma-grade polymers. The researchers were able to use these chemical substances to produce flexible, biodegradable rods containing the antibiotic. The small rods can be easily inserted into the gingival pocket. Since they are broken down by the body, they do not have to be removed after treatment. The rods are much more effective in vitro than previous products on the market, says Martin Kirchberg, who is studying the topic as part of ...
This third volume of the second edition offers information on specialized products such as emulsions, liposomes, polymers and polymeric pharmaceutical excipients. It explains the requirements for conducting clinical research and obtaining marketing approval for new drug products ...
Amorphous solid dispersions (SDs) are a promising approach to improve the dissolution rate of and oral bioavailability of poorly water-soluble drugs. In some cases multi-phase, instead of single-phase, SD systems with amorphous drug are obtained. While it is widely assumed that one-phase amorphous systems are desirable, two-phase systems may still potentially exhibit enhanced stability and dissolution advantages over undispersed systems. The objective of the present study was to understand the solid-state properties of two-phase SDs with amorphous drug and their relation to physical stability. Two different types of excipients for SD formation were used, one being a polymer and the other a small molecule excipient. The supercooled molten SDs of a poorly water-soluble indomethacin (IND) with a graft copolymer, Soluplus® (SOL) and sugar alcohol, xylitol (XYL) were prepared. Supercooled molten SDs of IND with SOL were two-phase glassy suspension in which the amorphous drug was dispersed in an ...
R.S. Guad; S.J. Surana; G.S. Talele; S.G. Talele; S.B. Gokhale (2006). Natural Excipients. Pragati Books Pvt. Ltd. ISBN 978-81- ...
for polymeric excipients. In case of thiolated chitosan, for instance, a more than 10,000-fold increase in viscosity within a ... Bernkop-schnürch, A; Krauland, AH; Leitner, VM; Palmberger, T (2004). "Thiomers: potential excipients for non-invasive peptide ... "Development of pre-activated α-cyclodextrin as a mucoadhesive excipient for intra-vesical drug delivery". Int. J. Pharm. 534 (1 ...
The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient ... It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a ... Some APIs may be tableted as pure substances, but this is rarely the case; most formulations include excipients. Normally, a ... Dry granulation requires drugs or excipients with cohesive properties, and a 'dry binder' may need to be added to the ...
ISBN 978-0-911910-28-5. Rowe RC (2009). "Aspartame". Handbook of Pharmaceutical Excipients. pp. 11-12. ISBN 978-1-58212-058-4 ...
International Pharmaceutical Excipients Council, 2010. Franck, A. (9 March 2007). "Technological functionality of inulin and ...
Rowe, Raymond (2009). Handbook of Pharmaceutical Excipients 6th Edition. London, UK: Pharmaceutical Press. pp. 56-58. ISBN 978- ... making it a useful excipient, but at the risk of causing damage to the surface of the eye. Laundry detergents and treatments. ... The use of appropriate excipients can also greatly enhance the spectrum, performance and detergency, and prevent deactivation ...
See also Excipient.) Diluents are also used in vaccines such as MMR to reconstitute the vaccine after storage. In underwater ...
Excipient Spernath A; Aserin A (December 2006). "Microemulsions as carriers for drugs and nutraceuticals". Adv Colloid ... Heo MY; Piao ZZ; Kim TW; Cao QR; Kim A; Lee BJ (May 2005). "Effect of solubilizing and microemulsifying excipients in ...
Excipient/tableting ingredient[edit]. In addition to its use in ophthalmic liquids, hypromellose has been used as an excipient ... Weiner, Myra L.; Lois A. Kotkoskie (1999). Excipient Toxicity and Safety. p. 8. ISBN 9780824782108. .. ... as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.[1][2] ...
Smolinske, Susan C (1992). Handbook of Food, Drug, and Cosmetic Excipients. CRC Press. pp. 75-76. ISBN 0-8493-3585-X. Golemanov ...
Smolinske SC (1992). Handbook of Food, Drug, and Cosmetic Excipients. p. 7. ISBN 0-8493-3585-X. Vivas N, Vivas de Gaulejac N, ...
CS1 maint: discouraged parameter (link) Smolinske, Susan C. (1992). Handbook of Food, Drug, and Cosmetic Excipients. CRC Press ...
Small amounts of oleic acid are used as an excipient in pharmaceuticals, and it is used as an emulsifying or solubilizing agent ... ISBN 978-84-613-4979-1. Smolinske, Susan C. (1992). Handbook of Food, Drug, and Cosmetic Excipients. pp. 247-8. ISBN 978-0-8493 ...
The doses of macrogol as an excipient are too low to have relevant contraindications. Allergy to macrogol is rare, and usually ... Macrogol is used as an excipient in many pharmaceutical products. Lower-molecular-weight variants are used as solvents in oral ... Smolinske, Susan C. (1992). Handbook of Food, Drug, and Cosmetic Excipients. p. 287. ISBN 9780849335853. "Pharmaceuticals". ... drugs that use it as an excipient, and peri-procedural substances such as ultrasound gel. Oral macrogol is generally well ...
Analytical Profiles of Drug Substances and Excipients. 25. Academic Press. p. 106. ISBN 978-0-12-260825-4. "Archived copy" (PDF ...
The primary excipients are established pharmacopoeial materials. Co-Processing Waste Materials in Cement Production On this ... Co-processing is a tool that is employed by pharmaceutical excipients manufacturers and formulation scientists to develop ... of the primary excipients. These modifications are reflected in the resulting coprocessed material as enhanced functionality. ... Rice husk Contaminated glass bottles Impregnated sludge Paint sludge Coprocessing is the combination of two or more excipients ...
Analytical Profiles of Drug Substances and Excipients. 29. pp. 261-320. doi:10.1016/S1075-6280(02)29009-6. ISBN 9780122608292. ...
ISBN 978-3-527-30247-5. Analytical Profiles of Drug Substances and Excipients. Academic Press. 20 March 1998. pp. 113-. ISBN ...
Asim, MH; Ijaz, M; Rösch, AC; Bernkop-Schnürch, A (2020). "Thiolated cyclodextrins: New perspectives for old excipients". ... Development with Lipid Excipients 2017 He is author of over 450 research articles and reviews as well as editor and (co-)author ...
Al-Majed; Analytical Profiles of Drug Substances and Excipients. 2001, 162, 429-441.. ...
Weiner, Myra L.; Kotkoskie, Lois A. (2000). Excipient Toxicity and Safety. New York: Dekker. p. 210. ISBN 978-0-8247-8210-8. ...
The pleasant taste and mouthfeel of mannitol also makes it a popular excipient for chewable tablets. Mannitol can be used to ... Weiner ML, Kotkoskie LA (1999). Excipient Toxicity and Safety. pp. 370. ISBN 9780824782108. Belcher R, Nutten AJ (1960). ...
It is used as an excipient, and topical ophthalmic protectant and lubricant. HPC is an ether of cellulose in which some of the ... Weiner, Myra L.; Lois A. Kotkoskie (1999). Excipient Toxicity and Safety. p. 8. ISBN 978-0-8247-8210-8. Sanders, Joshua C.; ...
Weiner, Myra L.; Kotkoskie, Lois A. (1999). Excipient Toxicity and Safety. p. 10. ISBN 9780824782108. Demuth; et al. (2017). " ... Ritter, Steve (2008). "What's That Stuff? Excipients: Inactive ingredients in medicines serve multiple functions in drug ...
... is also present as an excipient in some pharmaceutical drugs. Dermatologists use acetone with alcohol for acne ... Weiner, Myra L.; Lois A. Kotkoskie (1999). Excipient Toxicity and Safety. p. 32. ISBN 978-0-8247-8210-8. Inactive Ingredient ...
Asiri, Yousif A.; Mostafa, Gamal A.E. (2010). "Donepezil". Profiles of Drug Substances, Excipients and Related Methodology. 35 ...
doi:10.1007/s10847-021-01055-9. Wheate, Nial; Limantoro, Christina (2016). "Cucurbit[n]urils as excipients in pharmaceutical ... Lett., 2011, 13, 4898 Gu, Alice; Wheate, Nial (2021). "Macrocycles as drug-enhancing excipients in pharmaceutical formulations ...
Gu, Alice; Wheate, Nial (2021). "Macrocycles as drug-enhancing excipients in pharmaceutical formulations". Journal of Inclusion ...
Al-Wabli RI (2017). "Lomefloxacin". Profiles of Drug Substances, Excipients and Related Methodology. 42. Elsevier. pp. 193-240 ...
International Pharmaceutical Excipients Council is a global organization founded in 1991 representing producers, suppliers, and ... IFPMA Weiner, Myra L.; Lois A. Kotkoskie (2000). Excipient toxicity and safety. Informa Health Care. p. iv. ISBN 978-0-8247- ... each of which focuses on local regulations concerning the excipients market, as well as on new research and business practices ... end users of excipients. The body has three divisions in Europe, Japan, and the United States, ...
"Vaccine Excipient & Media Summary" (PDF). Juan C. Ravell (January 11, 2021). "A Simple Breakdown of the Ingredients in the ... Excipient Vaccine types Vaccination schedule Adjuvant Preservative Cell culture Growth medium The initial list is based on ... This is a list of excipients per vaccine, as published by the United States Centers for Disease Control. Vaccine ingredients ...
... enable an open exchange of information and perspectives between USP and users of USP Standards on topics within the Excipient ... Learn more about USPs Excipients Stakeholder Forum that took place on Wednesday, November 29, 2017. This annual forum is ... Excipients Stakeholder Forum: Stakeholder Forum Progress and Achievements Hong Wang, Senior Manager, Science - Excipients at ... The Excipients Stakeholder Forum provides an opportunity for manufacturers, distributors, users of excipients, and regulatory ...
Excipients in medicines may not be suitable for some people with a dietary intolerance or allergy: the total exposure to ... The most common type of enzymatic food intolerance is lactose intolerance.3 Excipients in medicines may not be suitable for ... Medicines, excipients, and dietary intolerances. BMJ 2017; 358 doi: https://doi.org/10.1136/bmj.j3468 (Published 21 August 2017 ... not only active drugs but also other ingredients included for a variety of purposes and collectively known as excipients.1 Here ...
... existing excipients with the various route of administration and co-processed excipients. These novel excipients increase the ... In source excipients market, plant-based excipients holds major share and is fastest growing segment at a CAGR of 7.3%. By ... Combination excipients are mostly preferred by the manufacturers as the single excipients do not meet all the functional ... Pharmaceutical Excipients Global Market-Forecast to 2022 * 1. Pharmaceutical Excipients Global Market- Forecast to 2022 Brought ...
USP Harmonization Status for Excipients (as of 26-Apr-2019). PDG#. Monograph Name. CP. PDG Harmonization Status (Sign-off date) ...
Pharmaceutical Formulation Excipients from Dow comply with international regulatory requirements and have been used in ... PHARMACEUTICAL FORMULATION EXCIPIENTS. At Dow Water & Process Solutions, our pharmaceutical-grade ion exchange resins (IX) are ... PHARMACEUTICAL FORMULATION EXCIPIENTS APPLICATIONS. From the stabilization of pharmaceutical preparations to enhanced ... used as functional excipients in numerous formulations that help to improve the delivery of drugs by offering formulation ...
PRNewswire/ -- According to a new market research report Sugar-Based Excipients Market by Product (Actual Sugars, Sugar ... Browse 125 market data Tables and 34 Figures spread through 187 Pages and in-depth TOC on Sugar-Based Excipients Market ... According to a new market research report Sugar-Based Excipients Market by Product (Actual Sugars, Sugar Alcohols, Artificial ... Based on regions, the sugar excipients market is segmented into North America, Europe, Asia-Pacific, and the Rest of the World. ...
Choose the right silicone excipient for your formulation. *Volatile Excipients: Clear, colorless solutions commonly used as ... Silicone Excipients. DOW CORNING™ offers a line of unique pharmaceutical excipients specifically developed for use in topical ... To ensure safe use in pharmaceutical formulations, these excipients are produced using key principles of pharmaceutical cGMPs. ... DOW CORNING™ brand topical pharmaceutical excipients are composed of silicone-based materials that enable innovative ...
Purchase Analytical Profiles of Drug Substances and Excipients, Volume 23 - 1st Edition. Print Book & E-Book. ISBN ... Analytical Profiles of Drug Substances and Excipients, Volume 23 1st Edition. 0.0 star rating Write a review ... He is also the Editor-In-Chief of the book series Profiles of Drug Substances, Excipients, and Related Methodology, having ... View all volumes in this series: Analytical Profiles of Drug Substances and Excipients ...
USP Novel Excipients Survey: Stakeholders Views on the Current State of Excipient Innovation. June 02, 2020 ... Analytical Method DevelopmentAPIsAseptic ProcessingBiologic DrugsDosage FormsDrug DeliveryEquipmentExcipientsFormulation ... Survey results indicate that the current regulatory approval pathway for excipients creates a challenge for the use of novel ... At the 2020 Bio/Pharma Virtual Congress, experts discuss the importance of characterizing excipients to ensure quality, safety ...
Handbook of Pharmaceutical Excipients (9780853693819) and a great selection of similar New, Used and Collectible Books ... Since many pharmaceutical excipients are also used in other applications, the Handbook will also be of value to persons with an ... The Handbook of Pharmaceutical Excipients collects, in a systematic and unified manner, essential data on the physical and ... a comprehensive guide to uses, properties and safety of pharmaeutical excipients...an essential reference source... also for ...
Inactive Ingredients / Excipients in Supplements. Inactive Ingredients in Vitamins and Supplements. Find Out Why Coloring ... For details, see the updated Titanium Dioxide section of the Inactive Ingredients/Excipients article. ... "excipients") following the list of Active Ingredients (see Where to Look on the Label). ConsumerLab also provides the full list ...
Roquette buys majority stake in India-based excipient manufacturer *. Biovation invests in equipment able to create any tablet ... Choosing the right excipient to meet future capsule challenges. Rousselot , Recorded the 31-Oct-2017 , Webinar ... TCC TB - Tricalcium citrate as excipient for direct compression TCC TB is a tricalcium citrate tetrahydrate designed to ... TCC TB - Tricalcium citrate as excipient for direct compression Jungbunzlauer , 05-Nov-2018 , Technical / White Paper ...
Excipients and Related Methodology, Volume 4 - 1st Edition. Print Book & E-Book. ISBN 9780122608049, 9780080860992 ... Profiles of Drug Substances, Excipients and Related Methodology, Volume 4 1st Edition. 0.0 star rating Write a review ...
Global Pharmaceutical Excipients Market: Drivers, Restraints and Trends. Although excipients are used in chemicals and food and ... Global Pharmaceutical Excipients Market: Drivers, Restraints and Trends. Although excipients are used in chemicals and food and ... Global Pharmaceutical Excipients Market: Region-wise Outlook. Europe has a sizeable pharmaceuticals excipients market, which is ... Global Pharmaceutical Excipients Market: Region-wise Outlook. Europe has a sizeable pharmaceuticals excipients market, which is ...
The excipient includes a hydrodrophilic matrix which includes a heteropolysaccharide and a polysaccharide material capable of ... A free-flowing directly compressible granulation useful as a slow release pharmaceutical excipient is disclosed. ... The excipients of the present invention have been preoptimized by providing an excipient product which may be mixed with a wide ... The excipient may comprise a physical admix of the gums along with a soluble excipient such as compressible sucrose, lactose or ...
PS 9100:2002 Pharmaceutical Excipients - An Updated GMP Standard for Excipients Suppliers ... Medicines and excipients are inseparable, with few exceptions - one cannot exist without the other. The Pharmaceutical Quality ... A global drug master file system may pave the way for faster qualifications of new excipients and the industrys acceptance of ... Behavior of Uptake of Moisture by Drugs and Excipients under Accelerated Conditions of Temperature and Humidity in the Absence ...
PRNewswire/ -- According to the new research report The Pharmaceutical Excipients Market by Products (Organic chemicals, ... Further, rising focus on development of biologics and new excipients will also drive the excipients market during the forecast ... According to the new research report The Pharmaceutical Excipients Market by Products (Organic chemicals, Inorganic Chemicals ... Browse 199 market data tables and 41 figures spread through 270 pages and in-depth TOC on Pharmaceutical Excipients Market ...
A very simple gradient elution Tlc system for the separation of some common fatty excipients of rather varying polarities in ... A very simple gradient elutionTlc system for the separation of some common fatty excipients of rather varying polarities in one ... The system is useful as a simple quality control for fatty excipients, ointment bases and complete ointments. ...
Find Chemical Excipients at Spectrum Chemical. SpectrumChemical.com carries a full line of fine chemicals, lab appliances and ... Chemical Excipients Chemical Excipients. Spectrum Chemical offers one of the largest selections of chemical excipients in the ... Spectrum specializes in providing over 250 of the top chemical excipients. All Spectrum Chemical excipients are manufactured, ... These useful excipients can also be used in the manufacturing of active substances by adding non-stick properties and other ...
USA Home > Product Directory > Biochemicals and Reagents > Excipients for R&D Use Only > Coatings ...
... An excipient is an inactive substance used as a carrier for the active ingredients of a medication. In many cases, an ... in such cases the substance in question may be dissolved into or mixed with an excipient. Excipients are also sometimes used to ... An excipient is an inactive substance used as a carrier for the active ingredients of a medication. In many cases, an "active" ... Types of excipients:. Antiadherents. Antiadherents are used to reduce the adhesion between the powder (granules) and the punch ...
Excipients. Besides our API portfolio, we are offering numerous Excipients. We will support you in performing individual risk ...
The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates ... A peptide comprised of the 17 N-terminus amino acid extension of T266, or a fragment thereof, could be used as an excipient to ... Thus, the invention can be used as an excipient to maintain or increase the solubility of a protein of interest in a ... Peptides as solubilizing excipients for transforming growth factor beta proteins. US 20040102378 A1 ...
The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide ... The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most ... A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry ... When the novel excipient of the invention utilizes a colloidal silicon dioxide, it has been found that the resultant excipient ...
The certification provides independent validation that Capsugels European manufacturing sites maintain excipient Good ... excipient GMP certification, and the related benefits to companies marketing pharmaceutical products in the European Union. ... The certification provides independent validation that Capsugels European manufacturing sites maintain excipient Good ... excipient GMP certification, and the related benefits to companies marketing pharmaceutical products in the European Union. ...
China excipient manufacturer & factory list, find qualified Chinese excipient manufacturers, suppliers, factories, exporters & ... Pharmaceutical Excipients 2-Hydroxypropyl-Beta-Cyclodextrin for Food and Cosmetics CAS: 128446-35-5 ... Pharmaceutical Excipients 2-Hydroxypropyl-Beta-Cyclodextrin for Food and Cosmetics CAS: 128446-35-5 ... Aluminum Composite Panel , Silicon Dioxide , Food Additive , Pharmaceutical Excipients , Pharmaceutical Intermediates Mgmt. ...
Safety assessment of excipients (SAFE) for orally inhaled drug products.. The development of new orally inhaled drug products ... Basics: Excipients Used in Nonsterile Compounding, Part 2.. The July-August 2019 issue of the International Journal of ... Home » Topics » Pharmacy » Research » Manipulation of pharmaceutical polymorphic transformation process using excipients. ... Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP.. Mechanistic understanding-based ...
... on Monday updated its annex to the European Commissions guideline on excipient labeling, adding five new excipients and ... Excipients are defined as any part of a drug other than the active pharmaceutical ingredient. Most excipients are thought to be ... EMA Adds New Excipients to Labeling Requirements. Posted 09 October 2017 By Michael Mezher The European Medicines Agency (EMA) ... on Monday updated its annex to the European Commissions guideline on excipient labeling, adding five new excipients and ...
  • At Dow Water & Process Solutions, our pharmaceutical-grade ion exchange resins (IX) are used as functional excipients in numerous formulations that help to improve the delivery of drugs by offering formulation flexibility in five key areas: taste masking, controlled release, abuse deterrence, solubility and stability. (dow.com)
  • On the basis of formulation, oral formulations accounted for the largest share in the global sugar excipients market due to it increased use of oral formulations such as tablets, capsules, solutions, and emulsions for various therapeutic areas. (prnewswire.com)
  • DOW CORNING™ offers a line of unique pharmaceutical excipients specifically developed for use in topical healthcare formulations. (dupont.com)
  • To ensure safe use in pharmaceutical formulations, these excipients are produced using key principles of pharmaceutical cGMPs. (dupont.com)
  • By improving the bioavailability of the Active Pharmaceutical Ingredients (API) and the sensory profile, our versatile range of silicone excipients can help you improve the efficacy of topical pharmaceutical formulations and patient compliance. (dupont.com)
  • Recently, functional excipients have gained greater focus due to their applications in formulations employing newly developed active pharmaceutical ingredients. (prnewswire.co.uk)
  • Excipients are also sometimes used to bulk up formulations with very potent active ingredients, to allow for convenient and accurate dosage. (bionity.com)
  • A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. (google.es)
  • On top of the segment's organic growth, topical excipients are benefiting from the switch to more advanced formulations in topical pharmaceutical products, which means adding benefits like sensory feel, bringing the topical formulations closer to cosmetic formulations. (klinegroup.com)
  • What are the current trends in the topical formulations market, and how are they affecting excipients? (klinegroup.com)
  • This report will be a comprehensive analysis of the excipients used in topical pharmaceutical formulations, the functions and properties each of the excipients bring to the formulations, their consumption and supply, and the drivers and restraints affecting the market. (klinegroup.com)
  • Offering bioadhesive excipients that enhance drug absorption via prolonged contact time with the eye for ocular topical formulations. (lubrizol.com)
  • To examine the effect of common excipients such as sugars (sorbitol versus sucrose) on bioequivalence between pharmaceutical formulations, using ranitidine and metoprolol as model drugs. (springer.com)
  • The cloud point of nonionic surfactants used in liquid formulations can be modulated through the proper choice of excipient. (ovid.com)
  • The effects of excipients on the viscosities of protein formulations are examined in a new application note published by Malvern Instruments in which low volume viscometry was performed with the recently launched Viscosizer 200. (nanotech-now.com)
  • The modified ASTM E 299-08 method has important applicability in the pharmaceutical industry as a method that can be used for preliminary screening of excipients and new formulations to predict potential oxidative degradation reactions. (ku.edu)
  • Excipients are essential components for the improvement of overall pharmaceutical activity and performance, both of which directly impact the characteristics of pharmaceutical formulations. (grandviewresearch.com)
  • Commercial formulations of sixteen HAART drug formulations with solvent and four excipients were mixed with substrate. (nih.gov)
  • How to use lipid excipients and lipid-based formulations in early stage development? (gattefosse.com)
  • Hong Wang, Senior Manager, Science - Excipients at USP, presents updates achieved through previous Stakeholder Forums, highlighting participation by a broad range of excipients stakeholders, including representatives from industry, regulatory agencies and USP in developing new and updated standards. (usp.org)
  • A large range of excipients that address the key factors needed for dosage form stability of probiotic supplements. (roquette.com)
  • JRS Pharma offers a wide range of excipients and tablet coatings, as well as technical support and biopharma services to the health science industry. (pharmaceutical-technology.com)
  • Liquid and solid excipients were then evaluated for active oxygen levels to demonstrate the utility and breadth of the modified method to cover a wide range of excipients. (ku.edu)
  • North America holds the largest share in the pharmaceutical excipient market due to rising demand for pharmaceutical and biopharmaceutical drugs and presence of a large number of excipient manufacturers in this region. (slideshare.net)
  • Based on regions, the sugar excipients market is segmented into North America , Europe , Asia-Pacific , and the Rest of the World. (prnewswire.com)
  • North America dominated the global Pharmaceutical Excipients market and is projected to witness CAGR of XX% during the first half of the forecast period i.e. 2021 to 2031. (visiongain.com)
  • The North America market for excipients in terms of revenue is growing at a CAGR of 5.3% from 2013 to 2018 as the U.S. has the biggest pharmaceutical market globally. (pitchengine.com)
  • This report studies the global market size of Polymer Based Solubility Enhancement Excipients in key regions like North America, Europe, Asia Pacific, Central & South America and Middle East & Africa, focuses on the consumption of Polymer Based Solubility Enhancement Excipients in these regions. (htfmarketreport.com)
  • The Albumin (as Excipient) Market report is given for the worldwide markets including growth, trends, competitive landscape study, and key regions development status ( North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa ) 2020-2029. (benzinga.com)
  • Mechanistic understanding-based selection of excipients may improve formulation development strategies for generic drug products and potentially accelerate their approval. (bioportfolio.com)
  • Below are a few guidelines for the selection of excipients in drug formulation . (pharmiweb.com)
  • The compatibility study of drugs and excipients provides useful information and reference for the selection of excipients in the prescription. (pharmiweb.com)
  • With The Pharmaceuticals Market comfortably poised to reach annual revenues of US$400 bn before the end of 2020 (according to the World Health Organization), the demand for excipients is expected to exhibit steady growth. (mynewsdesk.com)
  • The global excipients market should reach nearly $6.9 billion by 2020 from approximately $6.3 billion in 2015, at a compound annual growth rate (CAGR) of 1.9% from 2015 to 2020. (marketresearch.com)
  • Global Pharmaceutical Excipients market was valued at US$ xx Million in 2020 and is projected to reach at a market value of US$ xx Million by 2031. (visiongain.com)
  • In 2020, Evonik has launched RESOMER, which is a precise platform for custom functional polymeric excipients to facilitate pharmaceutical manufacturers to control parenteral drug products profile. (visiongain.com)
  • Latest Study Reports Albumin (as Excipient) Market risk, opportunity, and market summary and Predictions 2020-2029 has been Added on market.us. (benzinga.com)
  • Leaders from industry, regulatory authorities, and academia across the pharmaceutical landscape have already signed up for Excipient World 2020. (ipecamericas.org)
  • Booths are selling quickly - showcase your company at Excipient World 2020. (ipecamericas.org)
  • By the most conservative estimates of global Pharmaceutical Excipients market size (most likely outcome) will be a year-over-year revenue growth rate of XX% in 2021, from US$ 85360 million in 2020. (reportsnreports.com)
  • USP hosted its annual Excipients Stakeholder Forum on Wednesday, November 29, 2017. (usp.org)
  • John Giannone, USP's Senior Director of Strategic Marketing and Program Operations for Excipients, explains the background and messaging associated with USP's new look, which was launched in mid-2017. (usp.org)
  • EMAILWIRE.COM , July 17, 2017 ) An excipient is a synthetic or natural constituent formulated alongside the active ingredient of a medication, included for the purpose of inducing and catalysing a wide range of chemical and physical properties. (emailwire.com)
  • In 2017, the global Polymer Based Solubility Enhancement Excipients market size was xx million US$ and is forecast to xx million US in 2025, growing at a CAGR of xx% from 2018. (htfmarketreport.com)
  • To study and analyze the global Polymer Based Solubility Enhancement Excipients market size (value & volume) by company, key regions/countries, products and application, history data from 2013 to 2017, and forecast to 2025. (htfmarketreport.com)
  • The global excipients market size is expected to reach USD 6.9 billion by 2025, expanding at a CAGR of 6.02% from 2017 to 2025, according to a new report by Grand View Research, Inc. Globally increasing reach of generic medicines has been a major factor driving market growth. (grandviewresearch.com)
  • This is a list of excipients per vaccine, as published by the United States Centers for Disease Control. (wikipedia.org)
  • International Pharmaceutical Excipients Council is a global organization founded in 1991 representing producers, suppliers, and end users of excipients. (wikipedia.org)
  • The Excipients Stakeholder Forum provides an opportunity for manufacturers, distributors, users of excipients, and regulatory agencies to discuss topics in an open forum setting. (usp.org)
  • Manufacturers, suppliers, and users of excipients, whether members of a trade organization or independent. (uspnf.com)
  • Edited by the Associate Director of Analytical Research and Development for the AmericanAssociation of Pharmaceutical Scientists, Analytical Profiles of Drug Substances and Excipients brings this information together into one source. (elsevier.com)
  • Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. (dymocks.com.au)
  • The Food and Drug Administration (FDA) is announcing the availability of a revised guidance for industry (#100) entitled "Impurities: Residual Solvents in New Veterinary Medicinal Products, Active Substances and Excipients (Revision)" VICH GL18(R). This revised guidance has been developed for veterinary use by the International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products (VICH). (federalregister.gov)
  • Roquette Group ( France ), DFE Pharma ( Germany ), BASF SE ( Germany ), and Ashland Inc. (U.S.), held the major share of the sugar excipients market, and are expected to dominate the market during the forecast period. (prnewswire.com)
  • This report studies the global Pharmaceutical Excipients Market, with forecast to 2019. (prnewswire.co.uk)
  • Further, rising focus on development of biologics and new excipients will also drive the excipients market during the forecast period. (prnewswire.co.uk)
  • Persistence Market Research (PMR) published a research study on the cellulose derivative excipient market that involves a comprehensive industry analysis of historic 2014-2018 and forecast of 2019-2029. (bccresearch.com)
  • The volume analysis of the cellulose derivative excipient has been considered in tons, covering data from 2014-2018 (historic) and forecast period up to 2029 with 2018 as the base year. (bccresearch.com)
  • The following section of the report help readers understand the value (US$ Mn) and volume (Tons) forecast for the cellulose derivative excipient market on the basis of segments at a global level. (bccresearch.com)
  • The report covers all the major product segments of the excipients market and provides in-depth analysis, historical data and statistically refined forecast for the segments covered. (pitchengine.com)
  • What is the forecast consumption of excipients for topical pharmaceuticals from 2018 to 2023? (klinegroup.com)
  • To provide detailed analysis of the market structure along with forecast for the next 10 years of the various segments and sub-segments of the global Pharmaceutical Excipients Market. (medgadget.com)
  • The market in Asia Pacific is projected to witness substantial growth over the course of the forecast period thanks to several development projects undertaken across major economies, especially in newer excipients markets. (grandviewresearch.com)
  • In respect to excipients market by type, pregelatinized starch is expected to grow with the highest CAGR of 6.2% from 2013 to 2018 in terms of revenue and in terms of volumes the market for glycerin is growing with the highest CAGR of 6.4% from 2013 to 2018. (pitchengine.com)
  • The report then estimates 2018-2023 market development trends of OSDF Excipients industry. (researchandmarkets.com)
  • Depending on the route of administration , and form of medication, various excipients may be used. (bionity.com)
  • Pharmaceutical drug products contain various excipients in combination with the active pharmaceutical ingredient (API), and those excipients have the potential to have as impurities reactive oxygen species that can react directly with the API and lead to oxidative degradation. (ku.edu)
  • Europe Sugar based Excipients Market was worth USD 301.21 million in 2016 and estimated to be growing at a CAGR of 4.1%, to reach USD 368.23 million by 2021. (emailwire.com)
  • Some factors such as shortage of FDA-approved manufacturing sites due to rigorous regulatory requirements hinder sugar based excipients market growth to a certain extent. (emailwire.com)
  • Due to increasing investment in factors like drug development and production of the generic drug, as well as, favourable government policies made Eastern and Western Europe leading region in sugar based excipients market. (emailwire.com)
  • Written by nearly 100 pharmaceutical scientists expert in pharmaceutical formulation or excipients manufacture, the third edition contains 210 excipient monographs. (abebooks.com)
  • While industry guidances, excipient monographs, and compendial test methods provide some direction, sourcing and testing of excipients is an ongoing challenge for drug manufacturers. (sgs.com)
  • Pharmacopoeial monographs of pharmaceutical excipients rarely require testing for formaldehyde specifically [ 5 , 6 ]. (hindawi.com)
  • The body has three divisions in Europe, Japan, and the United States, each of which focuses on local regulations concerning the excipients market, as well as on new research and business practices. (wikipedia.org)
  • The Handbook of Pharmaceutical Excipients is internationally recognized as the authoritative source of information on pharmaceutical excipients. (abebooks.com)
  • The Handbook of Pharmaceutical Excipients collects, in a systematic and unified manner, essential data on the physical and chemical properties of excipients. (abebooks.com)
  • The Handbook of Pharmaceutical Excipients is a comprehensive, uniform guide to the uses, properties, and safety of pharmaceutical excipients. (abebooks.com)
  • The Handbook of Pharmaceutical Excipients contains essential data on the physical properties of excipients, their safe use and potential toxicity. (pharmpress.com)
  • The Handbook of Pharmaceutical Excipients collects together essential data on the physical properties of excipients as well as providing information on their safe use and applications. (pharmpress.com)
  • The mission statement of the cellulose derivative excipient market report is to offer the key insights on current trends, competition position, growth rates, market potential, and other relevant statistical information to readers and several stakeholders of the cellulose derivative excipient market in a suitable manner. (bccresearch.com)
  • USP hopes the forum will encourage excipients constituencies to work openly and directly with USP as well as collaborate with fellow stakeholders. (uspnf.com)
  • The five newly listed excipients include boric acid, cyclodextrins, phosphate buffers, sodium laurilsulfate and fragrances containing allergens. (raps.org)
  • Similarly, narrow pipeline of new chemical excipients, increasing preference of manufacturers for the direct compression (DC) process and technological advancement in tablets manufacturing, are some of the other factors that will give opportunity for the development of high-functionality excipients. (visiongain.com)
  • High Functionality Excipients simplify formulation development and improve overall operational costs while preserving the quality expected by the industry. (jrs.de)
  • High-functionality excipients (HFE) help simplify the formulation of oral dosage forms, improving overall costs and preserving quality. (pharmaceutical-technology.com)
  • Our current research covering solubility enhancement technologies and the related excipients market forecasts a compound annual growth rate (CAGR) of over 10% in the period from 2014 to 2024 for this highly important segment, driven by the demand for solubility enhancement excipients. (klinegroup.com)
  • Global Polymer Based Solubility Enhancement Excipients Market rev. (htfmarketreport.com)
  • This research report categorizes the global Polymer Based Solubility Enhancement Excipients market by players/brands, region, type and application. (htfmarketreport.com)
  • The objectives of this study are to define, segment, and project the size of the Polymer Based Solubility Enhancement Excipients market based on company, product type, application and key regions. (htfmarketreport.com)
  • The various contributors involved in the value chain of Polymer Based Solubility Enhancement Excipients include manufacturers, suppliers, distributors, intermediaries, and customers. (htfmarketreport.com)
  • To understand the structure of Polymer Based Solubility Enhancement Excipients market by identifying its various subsegments. (htfmarketreport.com)
  • Focuses on the key global Polymer Based Solubility Enhancement Excipients manufacturers, to define, describe and analyze the sales volume, value, market share, market competition landscape, SWOT analysis and development plans in next few years. (htfmarketreport.com)
  • To analyze the Polymer Based Solubility Enhancement Excipients with respect to individual growth trends, future prospects, and their contribution to the total market. (htfmarketreport.com)
  • To project the value and volume of Polymer Based Solubility Enhancement Excipients submarkets, with respect to key regions (along with their respective key countries). (htfmarketreport.com)
  • Both top-down and bottom-up approaches have been used to estimate and validate the market size of Polymer Based Solubility Enhancement Excipients market, to estimate the size of various other dependent submarkets in the overall market. (htfmarketreport.com)
  • During early stages of drug formulation development, excipients are evaluated for appropriateness by studying their physical and chemical compatibility with drug substances under stressed and accelerated conditions. (hindawi.com)
  • Depending on the results of the compatibility studies, formulator can exclude incompatible excipients from later stages of formulation development. (hindawi.com)
  • The system is useful as a simple quality control for fatty excipients, ointment bases and complete ointments. (springer.com)
  • The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide. (google.es)
  • The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. (google.es)
  • 1. An aqueous slurry useful in the preparation of a compressible pharmaceutical excipient, comprising a mixture of microcrystalline cellulose and from about 0.1% to about 20% by weight silicon dioxide based on the weight of said microcrystalline cellulose, said silicon dioxide having an average primary particle size from about 1 nm to about 100 μm, the solids content of said aqueous slurry being from about 0.5% to about 25% by weight. (google.es)
  • b) drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of said microcrystalline cellulose in intimate association with said silicon dioxide. (google.es)
  • It offers a detailed value-volume analysis of the cellulose derivative excipient market, along with the insights via base point share (BPS) analysis in (US$ Mn), analysis of the cellulose derivative excipient market attractiveness of each segment, and year-on-year growth on the basis of type, application, and end user. (bccresearch.com)
  • The cellulose derivative excipient market is segregated in two types such as cellulose ether derivatives and cellulose ester derivatives. (bccresearch.com)
  • The global cellulose derivative excipient market is a consolidated market with few players holding prominent shares of the market, in terms of value. (bccresearch.com)
  • The global cellulose derivative excipient market is highly competitive market due to the presence of a large number key manufacturers. (bccresearch.com)
  • The report is structured to help readers develop a thorough understanding of the global scenario of the cellulose derivative excipient market, stating with the definition and taxonomy followed by market definition, macroeconomic factors, and market dynamics, which includes drivers, restraints, opportunities, and trends. (bccresearch.com)
  • Each section of the cellulose derivative excipient market report covers a quantitative and qualitative assessment of the market on the basis of historical data, developments, accurate data, and key opinions collected from market participants through trends and interviews followed by the market. (bccresearch.com)
  • The global cellulose derivative excipient market value represented in the section has been compiled and finalized on the basis of data and information collection at all regional levels. (bccresearch.com)
  • The cellulose derivative excipient market information, along with the key observations and an accurate analysis framework such as segments year-on-year growth, market attractiveness, market share analysis, and incremental $ opportunity analysis. (bccresearch.com)
  • The following section represents a summarized overview of the cellulose derivative excipient market based on seven prominent regions considered in the study. (bccresearch.com)
  • DMV-Fonterra Excipients GmbH & Co KG, the 50/50 joint venture for pharmaceutical excipients between Dutch dairy company Royal FrieslandCampina and New Zealand dairy company Fonterra, signed a business transfer agreement for the acquisition of the business and assets of Brahmar Cellulose Private Limited (BCPL) in pharmaceutical Microcrystalline Cellulose (MCC) and Sodium Carboxyl Methyl Cellulose (SCMC) as of October 2011. (frieslandcampina.com)
  • DMV-Fonterra Excipients sources its products in Europe and New Zealand, while Brahmar Cellulose manufacturers its products in India. (frieslandcampina.com)
  • The acquisition of Brahmar Cellulose is a further step in achieving our ambition to become a leading supplier in pharmaceutical excipients and will give a stronger base for future developments in this area", says Jan Jongsma, CEO at DMV-Fonterra Excipients. (frieslandcampina.com)
  • DMV-Fonterra Excipients has an established global sales network which will be able to incorporate Brahmar Cellulose product range. (frieslandcampina.com)
  • Both Brahmar Cellulose business and DMV-Fonterra Excipients Business will initially continue to operate through current sales and distribution network. (frieslandcampina.com)
  • The Functional Additives Division of Asahi Kasei's Specialty Solutions SBU supplies Ceolus™ microcrystalline cellulose to pharmaceutical manufacturers around the world for use as an excipient for drug tablets. (biospectrumasia.com)
  • A major focus of this year's Excipients Stakeholder Forum was atypical actives (excipients used as active ingredients in pharmaceuticals), with perspectives on this hot topic from USP, FDA and industry. (usp.org)
  • An overview of the global market for excipients in pharmaceuticals, including examinations of the effects of a crisis in the global supply chain, the demands of quality by design (QbD), and concerns about drug safety. (marketresearch.com)
  • Some of the factors driving the growth of the excipients market include increasing demand for novel excipients and growth in the global pharmaceuticals market. (pitchengine.com)
  • What is the consumption of specialty excipients in topical pharmaceuticals in each region? (klinegroup.com)
  • What are the prices of various specialty excipients for topical pharmaceuticals? (klinegroup.com)
  • Excipients for Topical Pharmaceuticals Market Analysis and Opportunities will be comprised of two key deliverables-a fully interactive database based on a new platform and a report per excipient category and excipient group for each region covered in the study structured as shown in Table 1. (klinegroup.com)
  • By comparing results from our computational and experimental assessments, we gain insights into which material properties crucially determine the stability of pharmaceuticals in formulation with excipients in the solid state. (aiche.org)
  • DURECT Signs Long Term Excipient Supply Agreement With King Pharmaceuticals for. (bio-medicine.org)
  • As estimated by IQ4I Research the pharmaceutical excipient global market is poised to grow at a mid range single digit CAGR to reach $7,716 million by 2022. (slideshare.net)
  • Growth in this market can be attributed to factors such as increasing use of co-processed excipients, rapid growth in the generics market due to the patent expiration of many blockbuster drugs, and increasing development of orally disintegrating tablets (ODTs). (prnewswire.com)
  • In 2015, actual sugar accounted for the largest share of the global sugar excipients market. (prnewswire.com)
  • On the basis of type, powders/granules segment accounted for the large share of the global sugar excipients market. (prnewswire.com)
  • Europe is the largest regional segment for the global sugar excipients market. (prnewswire.com)
  • This report creates a holistic perspective of the current dynamics that govern the global pharmaceutical excipients market. (mynewsdesk.com)
  • How the tightening grip of regulators over the excipients used in the market will impact manufacturers and vendors is also assessed. (mynewsdesk.com)
  • This puts considerable pressure on manufacturers of pharmaceutical excipients who have to follow numerous process-related and regulatory procedures to bring their products to the market. (mynewsdesk.com)
  • Besides this factor, a slight but steady decline in the investment inflow in pharmaceutical R&D projects could act against the growth of the global pharmaceutical excipients market. (mynewsdesk.com)
  • While these two restraints remain a major concern, the scenario is anything but gloomy for companies operating in the global pharmaceutical excipients market. (mynewsdesk.com)
  • Opportunities in the global pharmaceutical excipients market are primarily centered on the growing scientific understanding of functionality excipients. (mynewsdesk.com)
  • The Pharmaceutical Excipients Market has witnessed a strong growth over the past few years. (prnewswire.co.uk)
  • However, declining investments on R&D by excipients manufacturers, and stringent regulatory requirements curbing the number of the U.S. FDA approved manufacturing sites are factors that inhibit the growth of this market to a certain extent. (prnewswire.co.uk)
  • The global Pharmaceutical Excipients Market is segmented by product, functionality, route of administration, and geography. (prnewswire.co.uk)
  • While the market by products is segmented into organic and inorganic chemicals, the market by route of administration is sub-segmented into oral, topical, parenteral, and other excipients. (prnewswire.co.uk)
  • Growth in investments on novel drug, and continuous efforts of pharmaceutical companies to offer superior-quality products are factors that have led to the large market shares of the North American and European Pharmaceutical Excipients Markets. (prnewswire.co.uk)
  • has been taken into consideration while estimating and forecasting the Pharmaceutical Excipients market. (visiongain.com)
  • Rapid surge in the generics drug is increasing demand of pharmaceutical excipients products due to this reason the factor is working as a driver for the market. (visiongain.com)
  • Due to the increasing geriatric population around the world is working as a driver for the pharmaceutical excipients market. (visiongain.com)
  • Top companies (Dupont De Nemours, Inc., Roquette Frères, Ashland Global Holdings Inc., and Evonik Industries AG) constitute more than XX% share of the global Pharmaceutical Excipients market. (visiongain.com)
  • The report elaborately discusses the potential of the Pharmaceutical Excipients market. (medgadget.com)
  • The global Pharmaceutical Excipients market report has its foundation in a segmentation based on type and route of Administration, dosage and end users. (medgadget.com)
  • Based on the type of material, the pharmaceutical excipient market is segmented into organic excipients, inorganic excipients and USP Water. (medgadget.com)
  • Based on route of administration, the pharmaceutical excipient market is segmented by-oral, injectable/parenteral, topical and advanced delivery systems. (medgadget.com)
  • By dosage forms, the pharmaceutical excipients the market segmentation includes solid dosage forms, liquid dosage forms, semi-solid dosage forms, and others. (medgadget.com)
  • In 2016, the synthetic segment held the largest share of the global pharmaceutical excipients market. (medindia.net)
  • The 194-page report provides clear detailed insight into the global pharmaceutical excipients market. (medindia.net)
  • Evonik Industries AG - BASF SE - Innophos Holdings Inc. - The Lubrizol Corporation - The DOW Chemical Company - Wacker Chemie AG - Ashland Inc. Visiongain's study is intended for anyone requiring commercial analyses for the global pharmaceutical excipients market. (medindia.net)
  • The demand of Pharmaceutical Excipients Market is increasing in the emerging markets, therefore proper expansion strategies, launching new product pipeline would be a lucrative opportunity for the companies operating in this industries. (emailwire.com)
  • Which suppliers are active in the market, and what excipients are they supplying? (klinegroup.com)
  • What is the inter-product competition in each regional market, and which excipients are preferred? (klinegroup.com)
  • The database will provide an overall market size of the excipient products by region and supplier. (klinegroup.com)
  • The 'Global and Chinese OSDF Excipients Industry, 2013-2023 Market Research Report' is a professional and in-depth study on the current state of the global OSDF Excipients industry with a focus on the Chinese market. (researchandmarkets.com)
  • The report provides key statistics on the market status of the OSDF Excipients manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry. (researchandmarkets.com)
  • Through the statistical analysis, the report depicts the global and Chinese total market of OSDF Excipients industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. (researchandmarkets.com)
  • 5.2 Market Competition of OSDF Excipients Industry by Country (USA, EU, Japan, Chinese etc. (researchandmarkets.com)
  • Competitive Analysis serves as the connection between companies and other participants prepared in Albumin (as Excipient) market, the report included with a related study of top market players with a business profile of competitive firms, Albumin (as Excipient) product modifications, cost structure, production plants and process, revenue details of past years and technologies used by them. (benzinga.com)
  • This report used the most reliable business analysis techniques to provide the most current information about Albumin (as Excipient) market competitors. (benzinga.com)
  • The acquisition will create a unique market position for DMV-Fonterra Excipients as the sole manufacturer and supplier of the most commonly used Diluents and Superdisintegrants to the Pharmaceutical industry. (frieslandcampina.com)
  • The transaction will bring together two companies that develop, produce and market excipients to the pharmaceutical industry. (frieslandcampina.com)
  • DMV-Fonterra Excipients will leverage its current quality and regulation framework and reputation to serve all levels of the pharmaceutical market. (frieslandcampina.com)
  • The major growth driver of Pharmaceutical Excipients Market includes growing demand of drug delivery system, growing pharmaceutical industry for functional excipients, and rising demand for biological drugs due to its immediate effects among others. (medgadget.com)
  • To Analyze the Pharmaceutical Excipients Market based on various factors- price analysis, supply chain analysis, porters five force analysis etc. (medgadget.com)
  • Pharmaceutical Excipients Market of Market Research Future comprises of extensive primary research along with the detailed analysis of qualitative as well as quantitative aspects by various industry experts, key opinion leaders to gain the deeper insight of the market and industry performance. (medgadget.com)
  • In addition, rising demand for newer excipients owing to the advantages of drug delivery and stability has led to the growth of the market. (grandviewresearch.com)
  • Determining the optimal formulation of a drug early in the process and using the correct excipient can accelerate a product's time-to-market and ensure both the drug's efficacy and improved patient compliance. (manufacturingchemist.com)
  • The three key factors that lift the market growth of sugar based excipients include increase usage of co-processed excipient, fast growth in the generics market due to finish of many bestselling drugs, and rising improvement of Orally Disintegrating Tablets (ODT). (emailwire.com)
  • European excipients market is segmented based on type, product, functionality and formulation. (emailwire.com)
  • Over the next five years the Pharmaceutical Excipients market will register a 6.1% CAGR in terms of revenue, the global market size will reach US$ 108260 million by 2026. (reportsnreports.com)
  • This report presents a comprehensive overview, market shares, and growth opportunities of Pharmaceutical Excipients market by product type, application, key manufacturers and key regions and countries. (reportsnreports.com)
  • From Active Pharmaceutical Ingredients (APIs) to excipients, intermediates to nutraceuticals, and animal care solutions to packaging materials, you can benefit from our product portfolio. (dksh.com)
  • Discussion of positive trends in the industry, including the development of creative ideas in response to the need for new excipients and new levels of cooperation between major players. (marketresearch.com)
  • 2. ABSTRACT Pharmaceutical excipients are inactive substances in the drug which helps in modulating solubility, bioavailability and stability of active substances for formulating final drug dosage forms. (slideshare.net)
  • Inactive ingredients are listed in the Supplement Facts Panel on dietary supplement labels as "Other Ingredients" (also referred to as "excipients") following the list of Active Ingredients (see Where to Look on the Label ). (consumerlab.com)
  • For details, see the updated Titanium Dioxide section of the Inactive Ingredients/Excipients article. (consumerlab.com)
  • An excipient is an inactive substance used as a carrier for the active ingredients of a medication. (bionity.com)
  • Most excipients are thought to be inactive, though some can cause reactions in certain circumstances. (raps.org)
  • The Pharmaceutical excipients are basically inactive substance used as a carrier for the active ingredients of a medication. (tradeindia.com)
  • Excipient World is devoted to scientific, regulatory and sourcing developments for excipients (the inactive ingredients used in the delivery of medications) and brings together experts from the excipient supplier and user community along with regulators from around the globe. (ipecamericas.org)
  • Excipient World , IPEC-Americas annual conference, attracts pharmaceutical professionals from America and around the world for a unique two day forum focused on excipients. (ipecamericas.org)
  • The support of IPEC-Americas imparts added value to Excipient World, attracting attendees, exhibitors and speakers from around the world. (ipecamericas.org)
  • Since the first Regulatory Affairs Conference in 1996, IPEC-Americas has hosted annual gatherings of excipient industry professionals in various locations throughout the U.S. and Puerto Rico. (ipecamericas.org)
  • In 2010, IPEC-Americas began its partnership with Excipient World to provide educational programming for the event. (ipecamericas.org)
  • This Joint CSPS/Health Canada/IPEC-Americas one day workshop intends to foster scientific discussions amongst Health Canada, industry and academia and will provide an opportunity to dialogue on issues of excipient science and their regulatory requirements. (cspscanada.org)
  • Evaluations of excipient technology by chemical compounds, functional uses, delivery systems and finished products. (marketresearch.com)
  • The demand for excipients is witnessing significant growth as it is considered as the functional additive in the pharmaceutical industry. (pitchengine.com)
  • High inherent functional performance that encompasses the overall formulation, unlike other multi-functional excipients or conventional specialty-grade excipients. (jrs.de)
  • What functional excipients for oral bioavailability enhancement do Gattefossé deliver? (gattefosse.com)
  • Our range of functional excipients includes oils, low HLB surfactants, high HLB surfactants and solvents. (gattefosse.com)
  • Roquette helps save and sustain lives as a trusted supplier of excipients and active pharmaceutical ingredients. (roquette.com)
  • Additionally, improvements have been made in the functionality of excipients, such as in a product's particle size and shape, which impacts its flow properties. (manufacturingchemist.com)
  • This article discusses the definition and significance of excipients, and highlights the importance of implementing the correct excipient manufacturing controls and standards. (pharmtech.com)
  • The potential impact of interactions between zinc ions and pharmaceutical excipients on absorption is very difficult to predict. (who.int)
  • If it is judged that the above-noted excipients are employed in quantities above the limit for which we have confidence that their impact will be negligible, additional information on the impact of that quantity of excipient on zinc absorption may be requested. (who.int)
  • it indicates that the use of other sweetening/flavouring excipients must be justified with supporting information on their impact on zinc absorption. (who.int)
  • TCC TB is a tricalcium citrate tetrahydrate designed to function as a direct compression excipient. (in-pharmatechnologist.com)
  • The tabletting properties of a new coprocessed excipient for direct compression were compared with a physical mixture of its components (separately and with drugs) and the individual constituents. (pharmtech.com)
  • Colorcon expands its portfolio of direct compression solutions, with the launch of StarTab, a tableting excipient based on starch. (in-pharmatechnologist.com)
  • Designed for use as a filler or diluent in tableting, TCC TB is an excipient also suitable for direct compression. (pharmaceutical-technology.com)
  • The obtained results showed that ODTs containing CBZ/HPβCD complex can be prepared by direct compression through the addition of co-processed excipients. (unboundmedicine.com)
  • In conclusion, the combination of five-in-one co-processed excipients and hydrophilic cyclodextrins may help addressing the ODT formulation of poorly soluble drugs with poor flowability, by direct compression and with desired release properties. (unboundmedicine.com)
  • Hence, various important steps are taken by key players such as modification in design and dosage forms, increasing focus on quality by design, and use of excipients in reformulation of drugs. (visiongain.com)
  • Solid dosage forms are not only made of active pharmaceutical ingredients (API) but also of excipients which improve the powder processing and the quality of the final dosage form. (anton-paar.com)
  • Some commonly used excipients are- gelatine, complex sugars and mannitol. (emailwire.com)
  • The July-August 2019 issue of the International Journal of Pharmaceutical Compounding includes part 1 of a 3-part article on the topic of excipients used in nonsterile compounding. (bioportfolio.com)
  • The ideal pharmacokinetic properties must have the right excipient for the intended pharmaceutical application. (medgadget.com)
  • In addition, necessary safety tests are required for certain physiologically active excipients, excipients that exceed conventional dosages and are not supported by literature, and excipients that change the route of administration. (pharmiweb.com)
  • The USP Excipients Stakeholder Forum was designed to enable an exchange of information and perspectives between USP and users of USP standards, with the ultimate goal of improving USP standards. (usp.org)
  • Click below to view presentations and audio from the Excipients Stakeholder forum on new USP branding, accelerated revision posting process, stakeholder forum updates and more. (usp.org)
  • The United States Pharmacopeia (USP) will be holding the first Excipients Stakeholder Forum on June 7, 2013 at USP's Rockville, Maryland, USA headquarters. (uspnf.com)
  • As companies strive to improve the efficacy and delivery of drugs, new opportunities are bound to emerge even in the pharma excipients space. (mynewsdesk.com)
  • LLS Health has extensive experience with solutions and suspensions, offering both innovative carbomer polymer excipients as well as contract development and manufacturing (CDMO) services in this space. (lubrizol.com)
  • Spectrum Chemical offers one of the largest selections of chemical excipients in the pharmaceutical industry. (spectrumchemical.com)
  • Spectrum specializes in providing over 250 of the top chemical excipients. (spectrumchemical.com)
  • All Spectrum Chemical excipients are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities. (spectrumchemical.com)
  • For instance, the rising interest in nanotechnology in drug delivery and endeavors to reduce the toxicity of drugs are initiatives that will pave the way for the use of innovative excipients. (mynewsdesk.com)
  • Excipients are also used in applications where the in-vitro integrity and stability of drugs need to be preserved. (mynewsdesk.com)
  • If the research proves that these parameters are very important to ensure the quality of the formulation, corresponding formulation or improvement should be made in order to ensure the stability of the quality of the excipients. (pharmiweb.com)
  • The choice of excipients is key to achieving this goal and can also impact the stability and shelf-life of the drug product. (manufacturingchemist.com)
  • Not only should the amount of excipient in a formulation remain beneath the permitted daily dose, but any physical properties of the excipients that may affect stability should also be considered. (manufacturingchemist.com)
  • Usually, the first step in a development programme is to a conduct a drug-excipient compatibility study to evaluate any unintended interaction between the excipient and the drug substance and avoid any negative impact on the product's stability or shelf-life. (manufacturingchemist.com)
  • In April, Meridica supplied its first Xcelodose system to North American contract research company MDS Pharma Services, which said it would use the system to help its customers start clinical trials of candidate drugs more quickly, as it does away with the need for excipient compatibility, stability and preformulation studies. (capsugel.com)
  • The excipients form the major part of any medicinal product and proportion of it when compared to Active Pharmaceutical Agent (API) exceeds two to three fold in any pharmaceutical preparations. (slideshare.net)
  • From the stabilization of pharmaceutical preparations to enhanced solubility and disintegration, we have the expertise to handle your excipient needs. (dow.com)
  • Excipients are the general term for other materials in preparations except for the main drug, and are an important part of pharmaceutical preparations. (pharmiweb.com)
  • For example, for oral solid preparations, several kinds of excipients can be selected. (pharmiweb.com)
  • The book describes the properties, analytical methods and the applications of different polyvinylpyrrolidone excipients (povidone, crospovidone, copovidone etc.) for use in pharmaceutical preparations. (springer.com)
  • These include coprocessed materials, which combine the properties of two or more separate excipients into one and provide formulators with a single, multifunctional excipient option, and ready-to-prepare coating preparations. (manufacturingchemist.com)
  • How to Select Excipients in Drug Formulation? (pharmiweb.com)
  • Most importantly, one needs to choose wisely among the several excipients for a drug formulation. (medgadget.com)
  • As a greater understanding of the interactions between drug molecules and even low levels of reactive impurities - such as peroxides and aldehydes - has evolved, excipient manufacturers have significantly improved the quality and purity of solvent excipients such as oils and polyethylene glycols (PEGs). (manufacturingchemist.com)
  • Using melt extrusion to prepare glass solutions of poorly water-soluble drugs with hydrophilic excipients offers an exciting and advantageous alternative to existing formulation methods such as spray-drying and co-melting. (pharmtech.com)
  • According to this latest study, the 2021 growth of Pharmaceutical Excipients will have significant change from previous year. (reportsnreports.com)
  • Chemical incompatibility with drug substances may result not only from direct reaction with excipients but also from reaction with excipient impurities. (hindawi.com)
  • These impurities include formaldehyde which could be generated by autoxidation degradation of many pharmaceutical excipients such as polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG) [ 1 - 4 ]. (hindawi.com)
  • Peroxy compounds are a common class of such reactive impurities, but there is an absence in the literature of a method for detection of total peroxide level in pharmaceutical excipients when the identity of the peroxy contaminant is not known. (ku.edu)
  • DOW CORNING™ brand topical pharmaceutical excipients are composed of silicone-based materials that enable innovative formulation solutions for the efficient delivery of APIs in topical forms like creams, lotions, gels, ointments, sprays or sticks. (dupont.com)
  • Pathway ™ TPU Excipients offer controlled drug release and compatibility with a wide range of active pharmaceutical ingredients (APIs). (lubrizol.com)
  • Also, EU-GMPs are established for finished drug products and APIs and not for excipients. (gmp-compliance.org)
  • Geidobler, Raimund (2014): Cyclodextrins as excipients in drying of proteins and controlled ice nucleation in freeze-drying. (uni-muenchen.de)
  • This work aimed to develop ODTs of poorly soluble drugs by combining cyclodextrins that form inclusion complexes to improve wetting and release properties, and directly compressible co-processed excipients able to promote rapid disintegration and solve the poor flowability typical of inclusion complexes. (unboundmedicine.com)
  • Excipient Vaccine types Vaccination schedule Adjuvant Preservative Cell culture Growth medium The initial list is based on information from the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) and thus limited to US-approved vaccines. (wikipedia.org)
  • Five protease inhibitors (Agenerase solution, Agenerase capsules, Norvir, Viracept, Kaletra, and Fortovase) and the excipient TPGS (d-alpha-tocopheryl polyethylene glycol 1000 succinate) inhibited lipase significantly at or below physiological concentrations. (nih.gov)
  • The certification provides independent validation that Capsugel's European manufacturing sites maintain excipient Good Manufacturing Practices (GMPs) and comply with current European Union regulations in the manufacturing of empty, two-piece hard capsules.This webinar covers the regulatory background regarding the EU Directive on Falsified Medicines, the process and scope of the EXCiPACT™ excipient GMP certification, and the related benefits to companies marketing pharmaceutical products in the European Union. (outsourcing-pharma.com)
  • Our excipients are manufactured under GMPs in ISO:9001 certified facilities, have established DMFs, and have been extensively tested for biocompatibility and safety. (lubrizol.com)
  • For the pharmaceutical industry, Jungbunzlauer offers a wide range of starting materials, excipients, and active pharmaceutical ingredients (API). (pharmaceutical-technology.com)
  • As parenteral drug delivery becomes more complex and sophisticated, excipients that can facilitate drug (or gene) delivery to specific therapeutic targets will be required. (pharmtech.com)
  • This study encompasses excipients in pharmaceutical and biopharmaceutical markets. (marketresearch.com)