Excipients. Medical search

Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.

Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)

Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.

The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)

The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.

Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)

Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.

The chemical and physical integrity of a pharmaceutical product.

Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.

The quality or state of being wettable or the degree to which something can be wet. This is also the ability of any solid surface to be wetted when in contact with a liquid whose surface tension is reduced so that the liquid spreads over the surface of the solid.

SURFACE-ACTIVE AGENTS that induce a dispersion of undissolved material throughout a liquid.

Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.

A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.

Dosage forms of a drug that act over a period of time by controlled-release processes or technology.

A complex mixture of PHOSPHOLIPIDS; GLYCOLIPIDS; and TRIGLYCERIDES; with substantial amounts of PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; and PHOSPHATIDYLINOSITOLS, which are sometimes loosely termed as 1,2-diacyl-3-phosphocholines. Lecithin is a component of the CELL MEMBRANE and commercially extracted from SOYBEANS and EGG YOLK. The emulsifying and surfactant properties are useful in FOOD ADDITIVES and for forming organogels (GELS).

The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.

Relating to the size of solids.

Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents. For reasons of their ingredients, method of preparation, or use, they do not fall into another group of products.

Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.

Technique whereby the weight of a sample can be followed over a period of time while its temperature is being changed (usually increased at a constant rate).

GLYCEROL esterified with a single acyl (FATTY ACIDS) chain.

The process of keeping pharmaceutical products in an appropriate location.

Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.

A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.

Removal of moisture from a substance (chemical, food, tissue, etc.).

Compounds that provide LUBRICATION between surfaces in order to reduce FRICTION.

Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.

A plant genus of the family CYPERACEAE. SESQUITERPENES are found in some of the species.

A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.

The mechanical property of material that determines its resistance to force. HARDNESS TESTS measure this property.

A device that delivers medication to the lungs in the form of a dry powder.

A measure of the amount of WATER VAPOR in the air.

Method of using a polycrystalline powder and Rietveld refinement (LEAST SQUARES ANALYSIS) of X-RAY DIFFRACTION or NEUTRON DIFFRACTION. It circumvents the difficulties of producing single large crystals.

A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.

An aromatic perennial plant species that has been used to treat migraines, arthritis, and as a febrifuge. It contains TANNINS, volatile oils (OILS, ESSENTIAL), and sesquiterpene lactones, especially parthenolide.

Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants.

Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.

A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids. (Stedman, 25th ed)

Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.

Salts and esters of the 12-carbon saturated monocarboxylic acid--lauric acid.

A test to determine the relative hardness of a metal, mineral, or other material according to one of several scales, such as Brinell, Mohs, Rockwell, Vickers, or Shore. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

A plant genus of the family COMBRETACEAE. Members contain arjunin, an ellagitannin (TANNINS).

Hard or soft soluble containers used for the oral administration of medicine.

Substances added to foods and medicine to improve the quality of taste.

A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.

Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.

Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.

Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).

Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)

A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.

Insulin derivatives and preparations that are designed to induce a rapid HYPOGLYCEMIC EFFECT.

Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.

The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)

A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.

The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A change of a substance from one form or state to another.

A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.

A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.

A polyester used for absorbable sutures & surgical mesh, especially in ophthalmic surgery. 2-Hydroxy-propanoic acid polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with 1,4-dioxane-2,5-dione copolymer of molecular weight about 80,000 daltons.

Flammable, amorphous, vegetable products of secretion or disintegration, usually formed in special cavities of plants. They are generally insoluble in water and soluble in alcohol, carbon tetrachloride, ether, or volatile oils. They are fusible and have a conchoidal fracture. They are the oxidation or polymerization products of the terpenes, and are mixtures of aromatic acids and esters. Most are soft and sticky, but harden after exposure to cold. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)

Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.

A generic term for a variety of compounds that contain silicon, oxygen, and magnesium, and may contain hydrogen. Examples include TALC and some kinds of ASBESTOS.

The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.

A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.

The presence of organisms, or any foreign material that makes a drug preparation impure.

Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.

The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.

Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4. (1/728)

1. The effect of IL-4 on responses to intraplantar (i.pl.) carrageenin, bradykinin, TNFalpha, IL-1beta, IL-8 and PGE2 was investigated in a model of mechanical hyperalgesia in rats. Also, the cellular source of the IL-4 was investigated. 2. IL-4, 30 min before the stimulus, inhibited responses to carrageenin, bradykinin, and TNFalpha, but not responses to IL-1beta, IL-8 and PGE2. 3. IL-4, 2 h before the injection of IL-1beta, did not affect the response to IL-1beta, whereas IL-4, 12 or 12+2 h before the IL-1beta, inhibited the hyperalgesia (-30%, -74%, respectively). 4. In murine peritoneal macrophages, murine IL-4 for 2 h before stimulation with LPS, inhibited (-40%) the production of IL-1beta but not PGE2. Murine IL-4 (for 16 h before stimulation with LPS) inhibited LPS-stimulated PGE2 but not IL-1beta. 5. Anti-murine IL-4 antibodies potentiated responses to carrageenin, bradykinin and TNFalpha, but not IL-1beta and IL-8, as well as responses to bradykinin in athymic rats but not in rats depleted of mast cells with compound 40/80. 6. These data suggest that IL-4 released by mast cells limits inflammatory hyperalgesia. During the early phase of the inflammatory response the mode of action of the IL-4 appears to be inhibition of the production TNFalpha, IL-1beta and IL-8. In the later phase of the response, in addition to inhibiting the production of pro-inflammatory cytokines, IL-4 also may inhibit the release of PGs. (+info)

The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. (2/728)

1. We have studied the behavioural effects of intraplantar injections of adenosine 5'-triphosphate (ATP) and related compounds in freely moving rats and investigated whether these nociceptive effects are augmented in the presence of inflammatory mediators. 2. We find that in normal animals ATP and analogues produce dose-dependent nocifensive behaviour (seen as bursts of elevation of the treated hindpaw), and localized thermal hyperalgesia. The rank order of potency was: alpha,beta-methyleneadenosine 5'-triphosphate (alpha,beta-methylene ATP) > 2-methylthioadenosine triphosphate (2-methylthio ATP) > ATP. After neonatal treatment with capsaicin, to destroy small calibre primary sensory neurones, nocifensive behaviour was largely absent. 3. The effects of ATP analogues were assessed in three models of peripheral sensitization: 2 h after dilute intraplantar carrageenan (0.25% w v(-1)); 24 h after irradiation of the hindpaw with ultraviolet (U.V.) B; immediately following prostaglandin E2 (PGE2) treatment. In all models the effect of alpha,beta-methylene ATP was greatly augmented. After carrageenan, significant hindpaw-lifting behaviour activity was induced by injection of only 0.05 nmol of alpha,beta-methylene ATP, some 100 times less than necessary in normal skin. 4. Our data suggest that it is much more likely that endogenous levels of ATP will reach levels capable of exciting nociceptors in inflamed versus normal skin. Our data also suggest the involvement of P2X3 receptor subunits in ATP-induced nociception. (+info)

A study of local anaesthetics. Part 148. Influence of auxiliary substances on the surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII. (3/728)

The influence of auxiliary substances of the polyol group (glycerol, propylene glycol, sorbitol) and of their concentration (5, 10, 15 and 20% by weight) upon surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII, viz., N-[2-(2-propoxyphenylcarbamoyloxy)-ethyl] piperidinium chloride was studied. The substances were applied as hydrogel humectants. It was found that their influence on the surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII depended on the type as well as concentration of the auxiliary substance. From the viewpoints of use in formulations of the drug form, sorbitol used at 5 and 10% concentrations represented the optimum. (+info)

Beneficial effects of raxofelast (IRFI 016), a new hydrophilic vitamin E-like antioxidant, in carrageenan-induced pleurisy. (4/728)

1. Peroxynitrite is a strong oxidant that results from reaction between NO and superoxide. It has been recently proposed that peroxynitrite plays a pathogenetic role in inflammatory processes. Here we have investigated the therapeutic efficacy of raxofelast, a new hydrophilic vitamin E-like antioxidant agent, in rats subjected to carrageenan-induced pleurisy. 2. In vivo treatment with raxofelast (5, 10, 20 mg kg(-1) intraperitoneally 5 min before carrageenan) prevented in a dose dependent manner carrageenan-induced pleural exudation and polymorphonuclear migration in rats subjected to carrageenan-induced pleurisy. Lung myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels, as well as histological organ injury were significantly reduced by raxofelast. 3. Immunohistochemical analysis for nitrotyrosine, a footprint of peroxynitrite, revealed a positive staining in lungs from carrageenan-treated rats. No positive nitrotyrosine staining was found in the lungs of the carrageenan-treated rats, which received raxofelast (20 mg kg 1) treatment. 4. Furthermore, in vivo raxofelast (5, 10, 20 mg kg(-1)) treatment significantly reduced peroxynitrite formation as measured by the oxidation of the fluorescent dihydrorhodamine 123, prevented the appearance of DNA damage, the decrease in mitochondrial respiration and partially restored the cellular level of NAD+ in ex vivo macrophages harvested from the pleural cavity of rats subjected to carrageenan-induced pleurisy. 5. In conclusion, our study demonstrates that raxofelast, a new hydrophilic vitamin E-like antioxidant agent, exerts multiple protective effects in carrageenan-induced acute inflammation. (+info)

Reduction of the cardiotoxicity of doxorubicin in rabbits and dogs by encapsulation in long-circulating, pegylated liposomes. (5/728)

The relative cardiotoxicity of pegylated (STEALTH) liposomal doxorubicin (PL-DOX; Doxil) was compared to nonliposomal doxorubicin (Adriamycin) in rabbits and dogs treated i.v. for up to 22 weeks. No histological evidence of cardiotoxicity was seen in dogs treated with placebo liposomes or PL-DOX every 3 weeks for a total of 10 doses (cumulative doxorubicin dose = 10 mg/kg) either 1 or 5 weeks post-treatment. All dogs treated with the same cumulative dose of free doxorubicin showed marked cardiotoxicity (vacuolization and myofibrillar loss in the myocardium) at both time points. In rabbits, progressive cardiomyopathy was seen in both treatment groups, but was more frequent and severe with free doxorubicin (67% of doxorubicin-treated rabbits, cumulative dose = 12 to 14 mg/kg versus 16% of PL-DOX-treated animals, cumulative dose = 14 to 21 mg/kg). Five doxorubicin-treated rabbits died of congestive heart failure or with histologic evidence of cardiotoxicity (median severity score = 6). No PL-DOX-treated rabbits died of congestive heart failure, although two animals that died early showed microscopic evidence of mild cardiotoxicity (median severity score = 2.5). Cardiotoxicity increased during the post-treatment period in both treatment groups. Rabbits received up to 50% more PL-DOX with no increase in cardiotoxicity. Thus, results in two species demonstrate that the cardiotoxicity of doxorubicin is significantly decreased when administered as PL-DOX. Significantly more PL-DOX can be given without incurring an increased risk of cardiomyopathy. Recent clinical studies have confirmed that PL-DOX is also less cardiotoxic than the same dose of unencapsulated doxorubicin in humans. (+info)

Enhancement of solubilization and biodegradation of polyaromatic hydrocarbons by the bioemulsifier alasan. (6/728)

Alasan, a high-molecular-weight bioemulsifier complex of an anionic polysaccharide and proteins that is produced by Acinetobacter radioresistens KA53 (S. Navon-Venezia, Z. Zosim, A. Gottlieb, R. Legmann, S. Carmeli, E. Z. Ron, and E. Rosenberg, Appl. Environ. Microbiol. 61:3240-3244, 1995), enhanced the aqueous solubility and biodegradation rates of polyaromatic hydrocarbons (PAHs). In the presence of 500 microg of alasan ml-1, the apparent aqueous solubilities of phenanthrene, fluoranthene, and pyrene were increased 6.6-, 25.7-, and 19.8-fold, respectively. Physicochemical characterization of the solubilization activity suggested that alasan solubilizes PAHs by a physical interaction, most likely of a hydrophobic nature, and that this interaction is slowly reversible. Moreover, the increase in apparent aqueous solubility of PAHs does not depend on the conformation of alasan and is not affected by the formation of multimolecular aggregates of alasan above its saturation concentration. The presence of alasan more than doubled the rate of [14C]fluoranthene mineralization and significantly increased the rate of [14C]phenanthrene mineralization by Sphingomonas paucimobilis EPA505. The results suggest that alasan-enhanced solubility of hydrophobic compounds has potential applications in bioremediation. (+info)

Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. (7/728)

Central sensitization, the hyperexcitability of spinal processing that often accompanies peripheral injury, is a major component of many persistent pain states. Here we report that the neurotrophin, brain-derived neurotrophic factor (BDNF), is a modulator of excitability within the spinal cord and contributes to the mechanism of central sensitization. BDNF, localized in primary sensory neuron cell bodies and central terminals, potentiates nociceptive spinal reflex responses in an in vitro spinal cord preparation and induces c-fos expression in dorsal horn neurons. NMDA receptor-mediated responses, known as a major contributor to central sensitization, were significantly enhanced by exogenous BDNF. Systemic NGF treatment, a procedure that mimics peripheral inflammatory states, raises BDNF levels in sensory neurons and increases nociceptive spinal reflex excitability. This increased central excitability is reduced by trkB-IgG, a BDNF "antagonist." We also show directly that inflammatory pain-related behavior depends on BDNF release in vivo. Thus behavioral nociceptive responses induced by intraplantar formalin and by intraplantar carageenan are significantly attenuated by trkB-IgG. Hence BDNF is appropriately localized and regulated in inflammatory states and is sufficient and necessary for the expression of central sensitization in the spinal cord. We propose that BDNF may function as a modulator of central sensitization in pathological states, and our results suggest that pharmacological antagonism of BDNF may prove an effective and novel analgesic strategy for the treatment of persistent inflammatory pain states. (+info)

Carrageenan primes leukocytes to enhance lipopolysaccharide-induced tumor necrosis factor alpha production. (8/728)

We have previously reported that pretreatment with carrageenan (CAR) enhances lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha) production in and lethality for mice. Whole blood cultured in vitro was used to show that CAR pretreatment results in about a 200-fold increase in LPS-induced TNF-alpha production. CAR by itself did not induce TNF-alpha production. However, CAR-treated cultured medium sensitized whole blood to make more LPS-induced TNF than did saline-treated cultured medium in vitro. It was also demonstrated that CAR pretreatment increases TNF-alpha mRNA levels of both blood cells and peritoneal exudate cells, but not of bone marrow cells. Immunoelectron microscopic analysis revealed that polymorphonuclear leukocytes and macrophages are TNF-alpha-producing cells in CAR-treated mice. In CAR-treated mice, TNF-alpha was seen early after LPS injection in leukocytes in hepatic sinusoids and on the surfaces of endothelial cells. TNF-alpha was also detected late after LPS injection in hepatocytes which become edematous. These results suggest that CAR primes leukocytes to produce TNF-alpha in response to LPS and that they play an important role in the pathogenesis of liver injury. (+info)

... is a global organization founded in 1991 representing producers, suppliers, and ... IFPMA Weiner, Myra L.; Lois A. Kotkoskie (2000). Excipient toxicity and safety. Informa Health Care. p. iv. ISBN 978-0-8247- ... each of which focuses on local regulations concerning the excipients market, as well as on new research and business practices ... end users of excipients. The body has three divisions in Europe, Japan, and the United States, ...

https://en.wikipedia.org/wiki/International_Pharmaceutical_Excipients_Council

"Vaccine Excipient & Media Summary" (PDF). Juan C. Ravell (January 11, 2021). "A Simple Breakdown of the Ingredients in the ... Excipient Vaccine types Vaccination schedule Adjuvant Preservative Cell culture Growth medium The initial list is based on ... This is a list of excipients per vaccine, as published by the United States Centers for Disease Control. Vaccine ingredients ...

https://en.wikipedia.org/wiki/List_of_vaccine_excipients

... because absence of excipient cannot always be assumed not to be a variable. Such studies are called excipient-controlled or ... "Excipients: Background/Introduction". In Katdare A, Chaubal M (eds.). Excipient Development for Pharmaceutical, Biotechnology, ... Excipients can also be useful in the manufacturing process, to aid in the handling of the active substance concerns such as by ... An excipient is a substance formulated alongside the active ingredient of a medication, included for the purpose of long-term ...

https://en.wikipedia.org/wiki/Excipient

The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient ... It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a ... Some APIs may be tableted as pure substances, but this is rarely the case; most formulations include excipients. Normally, a ... Dry granulation requires drugs or excipients with cohesive properties, and a 'dry binder' may need to be added to the ...

https://en.wikipedia.org/wiki/Tablet_(pharmacy)

R.S. Guad; S.J. Surana; G.S. Talele; S.G. Talele; S.B. Gokhale (2006). Natural Excipients. Pragati Books Pvt. Ltd. ISBN 978-81- ...

https://en.wikipedia.org/wiki/Cooking_oil

for polymeric excipients. In case of thiolated chitosan, for instance, a more than 10,000-fold increase in viscosity within a ... Laffleur, F; Bacher, L; Vanicek, S; Menzel, C; Muhammad, I (2016). "Next generation of buccadhesive excipient: Preactivated ... Bernkop-schnürch, A; Krauland, AH; Leitner, VM; Palmberger, T (2004). "Thiomers: potential excipients for non-invasive peptide ... "Development of pre-activated α-cyclodextrin as a mucoadhesive excipient for intra-vesical drug delivery". Int. J. Pharm. 534 (1 ...

https://en.wikipedia.org/wiki/Thiomer

ISBN 978-0-911910-28-5. Rowe RC (2009). "Aspartame". Handbook of Pharmaceutical Excipients. pp. 11-12. ISBN 978-1-58212-058-4 ...

https://en.wikipedia.org/wiki/Aspartame

International Pharmaceutical Excipients Council, 2010. Franck, A. (9 March 2007). "Technological functionality of inulin and ...

https://en.wikipedia.org/wiki/Inulin

Rowe, Raymond (2009). Handbook of Pharmaceutical Excipients 6th Edition. London, UK: Pharmaceutical Press. pp. 56-58. ISBN 978- ... making it a useful excipient, but at the risk of causing damage to the surface of the eye. Laundry detergents and treatments. ... The use of appropriate excipients can also greatly enhance the spectrum, performance and detergency, and prevent deactivation ...

https://en.wikipedia.org/wiki/Benzalkonium_chloride

See also Excipient.) Diluents are also used in vaccines such as MMR to reconstitute the vaccine after storage. In underwater ...

https://en.wikipedia.org/wiki/Diluent

"Macrogol as Excipient". Biesterfeld AG. Retrieved 10 June 2022. "PEG-3350 and Electrolytes for Oral Solution" (PDF). FDA. ... It is also used as an excipient. Side effects may include increased bowel gas, abdominal pain, and nausea. Rare but serious ... The doses of macrogol as an excipient are too low to have relevant contraindications. Allergy to macrogol is rare, and usually ... Macrogol is used as an excipient in pharmaceutical products. Lower-molecular-weight variants are used as solvents in oral ...

https://en.wikipedia.org/wiki/Macrogol

Excipient Spernath A; Aserin A (December 2006). "Microemulsions as carriers for drugs and nutraceuticals". Adv Colloid ... Heo MY; Piao ZZ; Kim TW; Cao QR; Kim A; Lee BJ (May 2005). "Effect of solubilizing and microemulsifying excipients in ...

https://en.wikipedia.org/wiki/Self-microemulsifying_drug_delivery_system

Smolinske, Susan C (1992). Handbook of Food, Drug, and Cosmetic Excipients. CRC Press. pp. 75-76. ISBN 0-8493-3585-X. Golemanov ...

https://en.wikipedia.org/wiki/Cetyl_alcohol

Smolinske SC (1992). Handbook of Food, Drug, and Cosmetic Excipients. p. 7. ISBN 0-8493-3585-X. Vivas N, Vivas de Gaulejac N, ...

https://en.wikipedia.org/wiki/Gum_arabic

Smolinske, Susan C. (1992). Handbook of Food, Drug, and Cosmetic Excipients. CRC Press. p. 347. ISBN 0-8493-3585-X. Yacoubou, ...

https://en.wikipedia.org/wiki/Resinous_glaze

"Error" (PDF). Analytical Profiles of Drug Substances and Excipients. Academic Press. 19 March 2001. pp. 155-. ISBN 978-0-08- ...

https://en.wikipedia.org/wiki/Flutamide

Small amounts of oleic acid are used as an excipient in pharmaceuticals, and it is used as an emulsifying or solubilizing agent ... ISBN 978-84-613-4979-1. Smolinske, Susan C. (1992). Handbook of Food, Drug, and Cosmetic Excipients. pp. 247-8. ISBN 978-0-8493 ... Excipients, Insect pheromones, Insect ecology, Insect repellents, Alkenoic acids). ...

https://en.wikipedia.org/wiki/Oleic_acid

Brittain, Harry G.; McLeish, Michael J (20 Mar 1998). Analytical Profiles of Drug Substances and Excipients. Vol. 25. Academic ...

https://en.wikipedia.org/wiki/Liebermann_reagent

The primary excipients are established pharmacopoeial materials. Co-Processing Waste Materials in Cement Production On this ... Co-processing is a tool that is employed by pharmaceutical excipients manufacturers and formulation scientists to develop ... of the primary excipients. These modifications are reflected in the resulting coprocessed material as enhanced functionality. ... Rice husk Contaminated glass bottles Impregnated sludge Paint sludge Coprocessing is the combination of two or more excipients ...

https://en.wikipedia.org/wiki/Co-processing

Analytical Profiles of Drug Substances and Excipients. Vol. 29. pp. 261-320. doi:10.1016/S1075-6280(02)29009-6. ISBN ...

https://en.wikipedia.org/wiki/7α-Thiomethylspironolactone_sulfoxide

Analytical Profiles of Drug Substances and Excipients. Academic Press. 1992. p. 4. ISBN 9780080861159. Archived from the ...

https://en.wikipedia.org/wiki/Amiodarone

ISBN 978-3-527-30247-5. Analytical Profiles of Drug Substances and Excipients. Academic Press. 20 March 1998. pp. 113-. ISBN ...

https://en.wikipedia.org/wiki/Clomifenoxide

Asim, MH; Ijaz, M; Rösch, AC; Bernkop-Schnürch, A (2020). "Thiolated cyclodextrins: New perspectives for old excipients". ... Assim, HM; Ijaz, M; Rösch, AC; Bernkop-Schnürch, A (2020). "Thiolated cyclodextrins: New perspectives for old excipients". ... Development with Lipid Excipients 2017 Phoenix Science Award for Pharmacy 2022 He is author of over 500 research articles and ... A Potential Multifunctional Excipient for Ocular Drug Delivery". Int J Mol Sci. 23: 2612. doi:10.3390/ijms23052612. PMID ...

https://en.wikipedia.org/wiki/Andreas_Bernkop-Schnürch

Al-Majed; Analytical Profiles of Drug Substances and Excipients. 2001, 162, 429-441. (Webarchive template wayback links, Liquid ...

https://en.wikipedia.org/wiki/Electroextraction

Weiner, Myra L.; Kotkoskie, Lois A. (2000). Excipient Toxicity and Safety. New York: Dekker. p. 210. ISBN 978-0-8247-8210-8. ...

https://en.wikipedia.org/wiki/Cellulose

The pleasant taste and mouthfeel of mannitol also makes it a popular excipient for chewable tablets. Mannitol can be used to ... Weiner ML, Kotkoskie LA (1999). Excipient Toxicity and Safety. pp. 370. ISBN 9780824782108. Belcher R, Nutten AJ (1960). ... Excipients, Glycerols, Nephrotoxins, Osmotic diuretics, Wikipedia medicine articles ready to translate, Sugar alcohols, Sugar ...

https://en.wikipedia.org/wiki/Mannitol

In addition to its use in ophthalmic liquids, hypromellose has been used as an excipient in oral tablet and capsule ... Weiner, Myra L.; Lois A. Kotkoskie (1999). Excipient Toxicity and Safety. p. 8. ISBN 9780824782108. Reddy, Indra K.; Riz̤ā ... as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products. As a ...

https://en.wikipedia.org/wiki/Hypromellose

It is used as an excipient, and topical ophthalmic protectant and lubricant. HPC is an ether of cellulose in which some of the ... Weiner, Myra L.; Lois A. Kotkoskie (1999). Excipient Toxicity and Safety. p. 8. ISBN 978-0-8247-8210-8. Sanders, Joshua C.; ... Excipients, Cellulose, Cellulose ethers, E-number additives). ...

https://en.wikipedia.org/wiki/Hydroxypropyl_cellulose

Weiner, Myra L.; Kotkoskie, Lois A. (1999). Excipient Toxicity and Safety. p. 10. ISBN 9780824782108. Demuth; et al. (2017). " ... Ritter, Steve (2008). "What's That Stuff? Excipients: Inactive ingredients in medicines serve multiple functions in drug ...

https://en.wikipedia.org/wiki/Magnesium_stearate

... is also present as an excipient in some pharmaceutical drugs. Dermatologists use acetone with alcohol for acne ... Weiner, Myra L.; Lois A. Kotkoskie (1999). Excipient Toxicity and Safety. p. 32. ISBN 978-0-8247-8210-8. Inactive Ingredient ... Excipients, Commodity chemicals, GABAA receptor positive allosteric modulators, Anticonvulsants). ...

https://en.wikipedia.org/wiki/Acetone

Excipient selection strongly influences lyophilization performance for biologic drugs. ... "The selection of excipients is empirical, and pharmaceutical scientists first evaluate excipients that have a precedent in ... can help to predict or rule out various excipients or combinations of excipients, adds Thompson-Madsen. FDM enables the ... Using a novel excipient that has no precedent requires additional safety data and the cost and risk associated with this path ...

https://www.biopharminternational.com/view/lyophilization-excipients-really-do-matter

The diversity and variability of excipients and their fragmented supply chains allow for unknown risks to quality. Additionally ... as well as excipients, or the other ingredients that help the API do its work in the body. ... there are no harmonized approaches for regulating excipients for medicines. ... Because they comprise up to 90% of medications, the quality of excipients is critical for a drug to be safe and effective. Read ...

https://www.usp.org/our-impact/quality-institute/excipients-research

Joint FAO/WHO Expert Committee on Food Additives. Meeting (‎46th : 1996: Geneva, Switzerland)‎; World Health Organization; Food and Agriculture Organization of the United Nations; International Programme on Chemical Safety (‎World Health OrganizationWorld Health Organization, 1996)‎ ...

https://extranet.who.int/iris/restricted/browse?authority=Excipients&type=mesh

The present study is focused on the thermal decomposition of Levofloxacin in the absence and presence of different excipients ( ... DSC curves of Levofloxacin and Excipients alone and Levofloxacin with excipients; A-Levofloxacin, B-Sodium starch glycolate, C- ... Figure 5 exposes DSC curves of drug, excipient and drug-excipient mixtures. ... 5: DSC curves of Levofloxacin and Excipients alone and Levofloxacin with excipients; ...

https://www.researchgate.net/publication/331905359_Decomposition_Kinetics_of_Levofloxacin_Drug-Excipient_Interaction

The global sustained release excipients market size was valued at USD 1.19 billion in 2021 and is expected to grow at a ... Sustained Release Excipients Market Size Report, 2022-2030 GVR Report cover Sustained Release Excipients Market Size, Share & ... How big is the sustained release excipients market? b. The global sustained release excipients market size was estimated at USD ... What is the sustained release excipients market growth? b. The global sustained release excipients market is expected to grow ...

https://www.grandviewresearch.com/industry-analysis/sustained-release-excipients-market

Excipient World is the leading education, networking and sourcing resource for the $6+ billion and growing global excipient ... Its the ONLY U.S. event focused exclusively on excipients and their vital role in the development, formulation, quality, ...

https://www.ashland.com/about/events/excipient-world-conference--expo-2021

Factors for assessing excipient variability, the associated challenges developers need to address to design and manufacture ... www.pharmtech.com/excipient. ) in 2012. Participating in that webcast were Catherine Sheehan, director of excipients at the US ... Although excipients are required to meet the appropriate pharmacopeia standards, there may be differences in the excipient ... So one may ask, why are excipients variable, and what are the sources of variability? Well, excipients used within the ...

https://www.pharmtech.com/view/quality-design-excipients

... the global revenues of the pharmaceutical excipients market are expected to grow at a CAGR of 5.8% in the coming years. ... Related tags: Excipients, Excipient, Generics, Small molecule drugs Bolstered by manufacturing advancements, the global ... Global pharmaceutical excipients market. Organic chemicals in high demand. Among the segments of the pharmaceutical excipients ... In aggregate, excipients manufactured in oral formulations produced nearly 57% of the market revenues in 2019, at a total ...

https://www.outsourcing-pharma.com/Article/2019/08/28/Growth-of-the-pharmaceutical-excipients-market

Featured Excipient: Flavor Enhancing Agents. Allen Loyd V Jr Jan/Feb 2003. 48-50. Buy. ... Polysorbates, Featured Excipient:. Allen Loyd V Jr Mar/Apr 2002. 147-148. Buy. ... Featured Excipient: Plasticizers. Allen Loyd V Jr Mar/Apr 2003. 145-148. Buy. ... Wetting and/or Solubilizing Agents, Featured Excipient:. Allen Loyd V Jr Jul/Aug 2001. 310-312. Buy. ...

https://ijpc.com/Abstracts/Abstract.cfm?ABS=824

CordenPharma and Moderna extended a strategic manufacturing services agreement for the supply of lipid excipients to be used in ... CordenPharma and Moderna extended a strategic manufacturing services agreement for the supply of lipid excipients to be used in ... CordenPharma to Manufacture Lipid Excipients for Modernas Vaccine. .social-ris-container { display: flex; justify-content: ... extended their existing manufacturing agreement with Moderna to manufacture large-scale volumes of Modernas lipid excipients ...

https://www.biopharminternational.com/view/cordenpharma-manufacture-lipid-excipients-modernas-vaccine-0

This blog is about a recent publication on using Hansen Solubility Parameters to predict excipient impacts on drug packaging ... Besides the physical interactions between the excipients and silicone oil, the degradation of excipients due to the chemical ... how likely an excipient, or combination of excipients, will be to interact with (and potentially remove) a coating such as ... But what about the converse? How do we make sure that the drug, or more specifically its added excipients, does not affect the ...

https://www.westpharma.com/blog/2021/november/using-hansen-solubility-parameters-to-predict-excipient-impacts

The Nitrites in Excipients data sharing consortium was established in September 2020 and is part of Lhasa Limited's effort ... Nitrite analysis of excipients is a new and analytically challenging area, with many organisations working quickly to determine ... 79 excipients. Lhasa is enthusiastic and excited about the continuation and growth of the Nitrites in Excipients database, and ... the Nitrites in Excipients database allows members to gain a better understanding of the risk posed by excipients in the final ...

https://www.lhasalimited.org/blog/nitrites-in-excipients-data-sharing-consortium-supporting-nitrosamine-risk-assessment/10891

... a novel surfactant excipient able to more rapidly stabilise than conventional excipients. ... DuPont Nutrition & Health advancements in novel excipients recognised by pharmaceutical journal. 19-Dec-2018 ... The published paper, "Dynamic Properties of Novel Excipient Suggest Mechanism for Improved Performance in Liquid Stabilization ... The researchers found the excipient delivered improved performance in liquid stabilisation of protein biologics, providing a ...

https://www.manufacturingchemist.com/news/article_page/DuPont_Nutrition_and_Health_advancements_in_novel_excipients_recognised_by_pharmaceutical_journal/150299

The pharmaceutical excipients market is projected to reach USD 11.5 Billion by 2027 from USD 8.6 Billion in 2022, at a CAGR of ... FIGURE 10PHARMACEUTICAL EXCIPIENTS MARKET, BY PRODUCT, 2022 VS. 2027 (USD MILLION)70. FIGURE 11PHARMACEUTICAL EXCIPIENTS MARKET ... FIGURE 10PHARMACEUTICAL EXCIPIENTS MARKET, BY PRODUCT, 2022 VS. 2027 (USD MILLION)70. FIGURE 11PHARMACEUTICAL EXCIPIENTS MARKET ... FIGURE 7PHARMACEUTICAL EXCIPIENTS MARKET (SUPPLY SIDE): CAGR PROJECTIONS67. FIGURE 8PHARMACEUTICAL EXCIPIENTS MARKET (DEMAND- ...

https://www.bharatbook.com/report/1356290/pharmaceutical-excipients-market-by-product-organic-chemicals-carbohydrates-inorganic-chemicals-calcium-phosphate-functionality-fillers-binders-lubricants-preservatives-formulation-tablets-capsules-parenteral-global-forecast-to

... between 2023 to 2032.Pharmaceutical excipients are substances that are added to the active pharmaceutical ingredients (prodrug ... The global Pharmaceutical Excipients market size was estimated to be US$ 8.3 billion in 2021 and is expected grow at a CAGR of ... Regional performance of Pharmaceutical Excipients Market. Key sales and growth in the pharmaceutical excipient industry are ... The global Pharmaceutical Excipients market size was estimated to be US$ 8.3 billion in 2021 and is expected grow at a CAGR of ...

https://www.pharmiweb.com/press-release/2022-11-09/pharmaceutical-excipients-market-exhibiting-cagr-of-61-by-2032-due-to-the-growing-demand-for-oral

Global Biopharmaceutical Excipients Market Size Will Reach USD 3.07 Billion by 2026: Facts & Factors. * ... Global Biopharmaceutical Excipients Market Size Will Reach USD 3.07 Billion by 2026: Facts & Factors ...

https://www.pm360online.com/global-biopharmaceutical-excipients-market-size-will-reach-usd-3-07-billion-by-2026-facts-factors/

Study at Kings College London with collaborators from Dubai Police and APDN concludes that DNA tagging excipients can mitigate ...

https://adnas.com/molecular-tagging-pharmaceutical-excipients-utilizing-apdn-technology-peer-reviewed-journal/

Exbumin is the only recombinant human serum albumin excipient available to improve viral stability for vaccines & gene ... Be the first to review "Exbumin® - Recombinant human albumin excipient" Cancel reply. You must be logged in to post a review. ... It is one of the few excipients available to improve viral stability for vaccines and gene therapies. Exbumin is also used to ... Exbumin has been approved for use as an excipient in injectable therapeutics by regulatory agencies. ...

https://invitria.com/products/exbumin-rhsa-excipient/?attribute_size=100+g

Please note: Our products and services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures ...

https://www.formulationbio.com/glycerin-gelatin-item-2045.html

... a global leader in high-quality functional excipients for pharmaceuticals and nutraceuticals. ... DFE Pharmas excipients offer advantages such as high-cost efficiency, consistent high quality, and adaptability to meet the ... This new partnership allows Azelis to exclusively distribute the following DFE Pharma excipients: Nutracel®, Pharmacel® and ... Azelis announces distribution mandate for DFE Pharmas excipient solutions to EMEA countries. 31 October 2022 ...

https://www.azelis.com/en/news/azelis-announces-distribution-mandate-for-dfe-pharma%E2%80%99s-excipient-solutions-to-emea-countries

View our infographic created to celebrate the launch of the ninth edition of the Handbook of Pharmaceutical Excipients. ... A brief history of excipients. Find out more about the emergence and development of excipients from their first use BC to the ... The worlds most authoritative source of information on excipients The Handbook of Pharmaceutical Excipients is the definitive ... Pharmaceutical Excipients provides information on the characteristics and physical properties of excipients, including side ...

https://about.medicinescomplete.com/category-insights-brief-history-of-excipients/

Excipients, sometimes referred to as inactive or inert ingredients, are materials used every day in compounding and play a ... Describe excipient grades, types, and sources.. *Relate the role of excipients in stability, efficacy, and delivery of drugs in ... Describe excipient grades, types, and sources.. *Recognize the role of excipients in stability, efficacy, and delivery of drugs ... Identify fundamental excipients in compounded preparations.. *Select excipients based on functional role in a dosage form; ...

https://education.lp3network.com/webinars/practical-essentials-pharmaceutical-excipients

... - Ex*cip i*ent, a. [L. excipients, entis, p. pr. of exipere. See {Except}, v. t.] Taking an exception. [1913 Webster ... Excipient - An excipient is an inactive substance used as a carrier for the active ingredients of a medication. In many cases, ... Excipient - Un excipient désigne toute substance autre que le principe actif dans un médicament, un cosmétique ou un aliment. ... excipient - noun Etymology: Latin excipient , excipiens, present participle of excipere to take out, take up more at except ...

https://medicine.en-academic.com/22511/excipient

ESTHER] Probiotics Blue Premium No excipient Increase quantity for [DR. ESTHER] Probiotics Blue Premium No excipient ... ESTHER] Probiotics Blue Premium No excipient. [DR. ESTHER] Probiotics Blue Premium No excipient ... It is a pure, excipient-free product. (Free of silicon dioxide, magnesium stearate, synthetic flavoring, coloring, sweetener) ...

https://esther-mall.com/en-jp/products/11-dr-esther-probiotics-blue

The Handbook of Pharmaceutical Excipients is the definitive summary of excipient specifications including pharmacopeial ... The worlds most authoritative source of information on excipients ... The worlds most authoritative source of information on excipients. The Handbook of Pharmaceutical Excipients is the definitive ... Pharmaceutical Excipients provides information on the characteristics and physical properties of excipients, including side ...

https://www.cphi-online.com/pharmaceutical-excipients-prod1265336.html

Please enter function of excipients, e.g. sweetener, preservative, thickening agent, etc. which can be selected from the drop- ... Please refer Appendix 8.2 List of Prohibited and Restricted Excipients; and Appendix 8.3 Lists of Permitted and Restricted ...

https://npra.gov.my/index.php/my/excipient-combo.html

... research will help you understand the Pharmaceuticals and Excipients Market and carry out your companys growth strategy, as ...

https://southeast.newschannelnebraska.com/story/46854479/global-pharmaceuticals-and-excipients-market-with-top-companies-2022-business-growing-strategies-regional-growth-challenges-competitive-dynamics

... play a significant role in the formulation and administration of dosage forms and the drug development process. They ... The word excipient, derived from the Latin phrase excipere - to receive, to except, or take out, refers to any component other ... Excipients and active ingredients form the major components of drugs. However, excipients make up the bulk of drugs and ... The word excipient, derived from the Latin phrase excipere - to receive, to except, or take out, refers to any component other ...

https://www.nvronhealthcare.com/post/excipients

Sustained Release Excipients Market is projected to keep expanding over the forthcoming years; rise in the incidence of ... Sustained Release Excipients Market report explains a multitude of factors that have contributed towards market growth in ... and chronic diseases across the world has played a major role in the growth of the global sustained release excipients market ... Global Sustained Release Excipients Market: Overview. The demand within the global sustained release excipients market has been ...

https://www.tmrresearch.com/sustained-release-excipients-market

View our infographic created to celebrate the launch of the ninth edition of the Handbook of Pharmaceutical Excipients. (medicinescomplete.com)
The Handbook of Pharmaceutical Excipients is the definitive summary of excipient specifications including pharmacopeial information and their regulatory status, providing you with a one stop resource when researching an excipient for use. (medicinescomplete.com)
In this webinar, recorded at the end of last year, the Pharmaceutical Press team are joined by the editors of the Handbook of Pharmaceutical Excipients to discuss the publication's history and plans for the future. (cphi-online.com)

This work highlights the importance of using fundamental science to understand pharmaceutical and pharmaceutical ingredient behaviour," said lead researcher Joshua Katz, PhD, Research Scientist, DuPont Pharma Excipients. (manufacturingchemist.com)
This new partnership allows Azelis to exclusively distribute the following DFE Pharma excipients: Nutracel ® , Pharmacel ® and Pharmacel ® sMCC90, high quality MCCs and co-processed MCC (microcrystalline cellulose) used as filler and binder in oral dosage forms. (azelis.com)

The concentration of other excipients in the formulation then occurs, which allows the large molecules to come sufficiently close to interact with one another," Sacha observes. (biopharminternational.com)
It's the ONLY U.S. event focused exclusively on excipients and their vital role in the development, formulation, quality, compliance and availability of drugs and consumer healthcare products. (ashland.com)
Excipients play a crucial role in a formulation, and as part of the formulation, influence the quality of the final drug product. (pharmtech.com)
The term excipient refers to any member of a broad group of surfactants, preservatives, tonicity agents, and buffers which formulation scientists take great care to balance in order to provide the drug, such as a therapeutic protein, in its most effective and deliverable state. (westpharma.com)
The ability to predict the interactions between excipients, and even the drugs themselves, and any component with which they come into contact, means that formulation and packaging scientists can more quickly narrow down what will or will not work for their drug. (westpharma.com)
In an investigation presented at the 2018 PDA Universe of Pre-Filled Syringes (Risk of Drug Formulation and Syringe / Autoinjector Functionality) it was demonstrated using HSP calculations, along with experimental methods such as contact angle and interfacial tension, that there was a correlation between observed inconsistencies observed in syringe glide forces and excipients that were predicted to have a higher likelihood to interact with silicone oil. (westpharma.com)
The information learned should provide insight to help understand the careful selection of specific excipients and address formulation challenges and opportunities. (lp3network.com)
Excipients play a significant role in the formulation and administration of dosage forms and the drug development process. (nvronhealthcare.com)
Beyond increasing the bulk of formulation and simplifying the manufacturing process, excipients perform a variety of roles such as binding ingredients, boosting patient's acceptance and compliance (by masking unpleasant odors or tastes), enhancing the stability of active ingredients, extending viability and acting as diluents (for example, microcrystalline cellulose, starch), etc. (nvronhealthcare.com)
Whilst excipients are the lower cost and less active part of any end use formulation, they play a vital role in delivery, storage and quality of pharmaceutical products. (sgs-latam.com)
Co-processed excipient has received much more attention in the formulation development of various dosage forms, specially for tablet preparation by direct compression method. (who.int)
Furthermore, it opens the opportunity for development and use of single multifunctional excipient rather than multiple excipients in the formulation. (who.int)
Drug products combine active pharmaceutical ingredients with excipients in a final formulation for delivery to patients in liquid or lyophilized (freeze-dried) packaged forms - with the latter requiring reconstitution in the clinical setting. (bioprocessintl.com)

The global sustained release excipients market size was valued at USD 1.19 billion in 2021 and is expected to grow at a compound annual growth rate (CAGR) of 8.22% from 2022 to 2030. (grandviewresearch.com)
The global Pharmaceutical Excipients market size was estimated to be US$ 8.3 billion in 2021 and is expected grow at a CAGR of 6.1% between 2023 to 2032 . (pharmiweb.com)
150+ Pages Report] As per the latest Research and survey report issued by Precedence Research, the global pharmaceutical excipients market was valued at around USD 8.85 billion in 2021 and is expected to register revenues worth USD 14.2 billion by the end of 2030 , growing at an exceptional CAGR of approximately 5.39% between 2022 and 2030. (marketstatsnews.com)
2021 Hubei Humanwell pharmaceutical excipients Co., Ltd. (humanwellcaps.com)

Using the principle that "like dissolves like", HSP calculations determine how "alike" two materials are, and by extension, how likely an excipient, or combination of excipients, will be to interact with (and potentially remove) a coating such as silicone oil. (westpharma.com)
Co-processing is a novel concept of combining two or more excipients that possess specific advantages that cannot be achieved using a physical admixture of the same combination of excipients. (who.int)
With advantages offered by the upcoming newer combination of excipients and newer methods of co-processing, co-processed excipients are for sure going to gain attraction both from academia and pharmaceutical industry. (who.int)

Moreover, evaluation of the potential of controlled release excipients for the manufacturing of the COVID-19 vaccine is continued. (grandviewresearch.com)

This is also due to "better assimilation of topical excipients with liquid APIs and increased patient compliance due to sensorial effects on the dermal layer," M&M states. (outsourcing-pharma.com)
CordenPharma, a contract development and manufacturing organization (CDMO) for APIs, drug products, and pharmaceutical packaging, extended their existing manufacturing agreement with Moderna to manufacture large-scale volumes of Moderna's lipid excipients to be used in the manufacture of Moderna's vaccine candidate (mRNA-1273) against the novel coronavirus (SARS-CoV-2), the companies announced in a May 28, 2020 press release. (biopharminternational.com)
SIO HistorySIO's beginnings date back to 1907, and today, is one of the most important global pharmaceutical oil manufacturer.As a subsidiary of Archer Daniels Midland Company since 1996, our company manufactures state-of-the-art purified pharmaceutical oils that can be used as APIs or as excipients for oral, topical and injectable formulations of oil-soluble drugs. (ronpharm.com)

Our goal is to manufacture our supplements as pure as possible, so we don't use fillers, binders, or chemical excipients. (greenorganicsupplements.com)

The role of excipients is to ensure that this disruption is minimized," she says. (biopharminternational.com)
Recognize the role of excipients in stability, efficacy, and delivery of drugs. (lp3network.com)
Relate the role of excipients in stability, efficacy, and delivery of drugs in support of formula requirements. (lp3network.com)

Factors that are boosting the market's growth include technological advancements in functional and multifunctional excipients required for orphan drugs, which are being increasingly adopted. (outsourcing-pharma.com)
According to the report, this is also due to the rising demand for co-processed multifunctional excipients. (outsourcing-pharma.com)
The expanding usage of generic medications and increased demand for multifunctional excipients is expected to be the key contributors to growth and revenue in the pharmaceutical excipients market. (pharmiweb.com)

The present study is focused on the thermal decomposition of Levofloxacin in the absence and presence of different excipients (sodium starch glycolate, magnesium stearate, microcrystalline cellulose and lactose using Thermogravimetry (TG). (researchgate.net)
It has been shown that the interaction of the first three excipients (sodium starch glycolate, magnesium stearate, and microcrystalline cellulose) with Levofloxacin is physical in nature. (researchgate.net)
Excipients: water-soluble methylcellulose - 1 mg, magnesium stearate-1 mg. (russianfoods.com)

After Natural News revealed the complete list of vaccine excipient ingredients published by the CDC earlier this week, the vaccine-pushing mainstream media exploded with accusations that falsely claimed Natural News was writing "fake news. (newstarget.com)
First, a CDC document titled "Vaccine Excipient & Media Summary" lists all the vaccine excipient ingredients found in CDC-approved vaccines. (newstarget.com)

For the full list of excipients, see section 6.1.Stock Info Webcasts & Presentations. (cassefortisicure.it)

The most commonly used excipients are protectants, surfactants, buffers, and bulking agents, according to Alan Fites, a senior pharmaceutical scientist with Singota Solutions. (biopharminternational.com)
This webinar will provide an opportunity for attendees to gain a better understanding of commonly used excipients and their various functions in compounded preparations. (lp3network.com)

Medicines include an active pharmaceutical ingredient (API) as well as excipients, or the other ingredients that help the API do its work in the body. (usp.org)
Read about USP's work promoting quality of excipient ingredients. (usp.org)
Pharmaceutical excipients are substances that are added to the active pharmaceutical ingredients (prodrug) to enhance their stability, increase volume to ingestible levels, or facilitate delivery of drug in the body. (pharmiweb.com)
Polymers provide better shelf life and enable controlled/sustained release mechanisms for the active pharmaceutical ingredients and therefore have been mostly used as pharmaceutical excipients in a range of products. (pharmiweb.com)
Azelis, a leading global innovation service provider in the specialty chemicals and food ingredients industry, has been appointed as a distributor by DFE Pharma, a global leader in high-quality functional excipients for pharmaceuticals and nutraceuticals. (azelis.com)
Excipients, sometimes referred to as inactive or inert ingredients, are materials used every day in compounding and play a crucial role in the functionality and efficacy of many preparations. (lp3network.com)
Recognize the potential for excipient interactions with active drug(s) and other ingredients. (lp3network.com)
Recognize the relationship between excipients, active drug(s) and other ingredients. (lp3network.com)
Excipient - An excipient is an inactive substance used as a carrier for the active ingredients of a medication. (en-academic.com)
Excipients can either act as carriers (basis or vehicles) or diluents, etc., of the active ingredients or components. (nvronhealthcare.com)
Excipients and active ingredients form the major components of drugs. (nvronhealthcare.com)
As you can see from the screen shots of the document, below, the list of excipient ingredients is "current as of January 6, 2017," according to the CDC. (newstarget.com)
Excipients Included in U.S. Vaccines, by Vaccine" on the official website of the United States Centers for Disease Control and Prevention lists as ingredients cell lines cultured from aborted fetal cells. (asknoah.org)
Iris Ingredients is a leading importer and distributor of Pharmaceuticals Excipients. (cphi-online.com)

CordenPharma and Moderna extended a strategic manufacturing services agreement for the supply of lipid excipients to be used in Moderna's vaccine against SARS-CoV-2. (biopharminternational.com)

Excipients are the main components of controlled-release formulations. (grandviewresearch.com)
In aggregate, excipients manufactured in oral formulations produced nearly 57% of the market revenues in 2019, at a total figure of $3.9bn. (outsourcing-pharma.com)
However, the anticipated growth of the topical drug delivery market worldwide, bolstered by multiple factors, is expected to push the excipients of topical formulations to surpass those of oral drug delivery methods. (outsourcing-pharma.com)
According to the report, the excipients market for topical formulations will be growing by 7.4% year-on-year during the forecast period. (outsourcing-pharma.com)
By regularly sharing analytical data on the level of nitrites in excipients, consortium members are able to use this supporting data and knowledge to assess the likelihood that a nitrate or nitrite will react to form a nitrosamine in formulations. (lhasalimited.org)
Our excipients provide efficient direct compression tableting procedures for nutraceutical and herbal formulations. (sigachi.com)

The pharmaceutical excipients market is projected to reach USD 11.5 Billion by 2027 from USD 8.6 Billion in 2022, at a CAGR of 5.9% during the forecast period. (bharatbook.com)
The global pharmaceutical excipients market size is expected to reach USD 14.2 Billion by 2030, with a CAGR of 5.39% from 2022 to 2030. (marketstatsnews.com)
A recent study by Precedence Research on the pharmaceutical excipients market offers a forecast for 2022 and 2030. (marketstatsnews.com)

The sustained release excipients market in North America has been expanding due to the adoption of sustained drug release techniques across the medical industry in the US and Canada. (tmrresearch.com)
The North America regional market is projected to dominate the global biologic excipients market, accounting for a maximum revenue share of the global market by 2017 end. (marketresearchblog.org)
The North America, Western Europe, and Asia Pacific markets accounted for 77.3% of the total biologic excipients market share in terms of value in 2017. (marketresearchblog.org)

Identify fundamental excipients in compounded preparations. (lp3network.com)
Classify excipients into functional groups related to compounded preparations. (lp3network.com)
In cosmetology , alginates extracted from Ascophyllum are used as emulsifiers and emulsion stabilizers in creams and lotions, as excipients absorbable by the epidermis, in preparations such as gels, creams, shampoos. (europa.eu)
Although many physicians use different IVIG preparations interchangeably and with similar overall efficacy, the individual products differ from each other in final purification steps, IgA content, and excipients. (medscape.com)

blended with a suitable excipient which is normally an inert substance. (researchgate.net)
However, as opposed to popular assumptions, excipients are not always inactive or inert and may result in side effects or adverse reactions if misused. (nvronhealthcare.com)
These excipients help in forming inert or non-reactive matrices that successively help in diffusing drugs at a slow pace. (tmrresearch.com)

Microcrystalline cellulose and gelatinized starch are currently the biggest sales and revenue-generating products for the pharmaceutical excipients market. (pharmiweb.com)

ACAM2000 is provided as a lyophilized preparation of purified live virus containing the following non-active excipients: 6-8 mM HEPES (pH 6.5-7.5), 2% human serum albumin USP, 0.5 - 0.7% sodium chloride USP, 5% mannitol USP, and trace amounts of neomycin and polymyxin B. (newstarget.com)
Croscarmellose sodium (medicinal excipients) is a cross-linked, partially carboxymethylated sodium salt of cellulose, or a cross-linked polymer of sodium carboxymethyl cellulose. (bioherbkey.com)

Other manufacturers, in an effort to keep costs down, dilute their products with cheap fillers and excipients, which cheats you out of the active ingredient and contaminates your product with unneeded chemicals. (greenorganicsupplements.com)

Factors for assessing excipient variability, the associated challenges developers need to address to design and manufacture solid oral drug products, and solutions for such challenges are examined. (pharmtech.com)
Well, excipients used within the pharmaceutical drug products are diverse in terms of their chemistry, origin, manufacture, and also control. (pharmtech.com)
Indeed, between the multiple manufacturers of an excipient, it is likely there will be differences in the raw materials and the production process used, the scale of manufacture, and location, all which can contribute to the variability of an excipient product's physicochemical properties. (pharmtech.com)
Among the segments of the pharmaceutical excipients market, the manufacture of organic chemicals produced revenues of $5.8bn in 2019, accounting for 80% of the market. (outsourcing-pharma.com)
The word excipient, derived from the Latin phrase excipere - to receive, to except, or take out, refers to any component other than the active pharmaceutical ingredient contained in solid dosage forms or used to manufacture a finished pharmaceutical product (FPP). (nvronhealthcare.com)

Excipient - Un excipient désigne toute substance autre que le principe actif dans un médicament, un cosmétique ou un aliment. (en-academic.com)
excipient - [ɛk sɪpɪənt] noun an inactive substance that serves as the vehicle or medium for a drug or other active substance. (en-academic.com)
Within 20 years, peanut oil was the preferred "excipient" - meaning a substance formulated alongside the active ingredient of a medication for the purpose of long-term stabilization. (yogaesoteric.net)
Just as Pirkle does not break in this region of the drug substance imuran and excipients. (goldgreiner.de)

These excipients are most critical to the structure and ultimately the function of freeze-dried biologic drug products. (biopharminternational.com)
Managing excipient variability is an essential element in designing and manufacturing robust solid oral drug products and is an integral task in when applying quality-by-design (QbD) principles. (pharmtech.com)
With an increasing focus on QbD, both innovator and generic-drug developers will be required to demonstrate excipient risk management in relation to the drug products' critical quality attributes. (pharmtech.com)
Broadly speaking, we could consider two classes of excipient products. (pharmtech.com)
The natural or naturally derived excipient products and factors, including the crop source along with environmental variables, such as the growing and processing conditions, can all affect the physicochemical properties of the resultant excipient product. (pharmtech.com)
Excipient choice and the maintenance of exceptionally high standards of performance in use are absolutely key to the success of most modern pharmaceutical products. (sgs-latam.com)
This review article discusses the advantages of co-processing, the need of co-processed excipient, general steps in developing co-processed excipient, limitation of co-processed excipient, technologies used in developing co-processing excipients, co-processed excipients in the literature, marketed products and future trends. (who.int)
FDA also set a limit on 1,4-dioxane at 10 ppm in approving glycerides and polyglycerides for use as excipients in products such as dietary supplements (FDA 2006). (cdc.gov)

The growth of polymers in the pharmaceutical excipients market is expected to rise for all forms of administrations like liquids, tablets, and capsules during the projected period. (pharmiweb.com)
Polymers biologic excipients are anticipated to lead the biologic excipients market over the forecast period. (marketresearchblog.org)

Excipients not only affect the stability of proteins and other biologics, they also determine the appropriate operating parameters for the lyophilization process. (biopharminternational.com)
The researchers found the excipient delivered improved performance in liquid stabilisation of protein biologics, providing a mechanistic understanding of the key causes and drivers of protein aggregation. (manufacturingchemist.com)

Please enter function of excipients, e.g. sweetener, preservative, thickening agent, etc. which can be selected from the drop-down list. (npra.gov.my)

Regularly updated on MedicinesComplete, Pharmaceutical Excipients provides information on the characteristics and physical properties of excipients, including side effects, monographs which are thoroughly indexed for selecting excipients and support for research and knowledge. (medicinescomplete.com)

Because the conditions during freezing and drying are different, the stresses on biologic drug substances are different, and combinations of excipients are often required to provide the protection and stabilization required for a given protein, monoclonal antibody, etc. (biopharminternational.com)
Because they comprise up to 90% of medications, the quality of excipients is critical for a drug to be safe and effective. (usp.org)
Fourier Transform Infra Red Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) were used to study the possible drug - excipient interaction. (researchgate.net)
Understanding the effects of normal excipient variability is important to ensure that potential risks to drug-product quality are effectively managed. (pharmtech.com)
Often, knowledge and tools to proactively assess the effects of excipient variability upon drug-product quality are available. (pharmtech.com)
Expirations of drug patents in European countries, which open the road for generics manufacturing, such as in the case of Pfizer's blockbuster Lyrica , have led the European Union (EU) market to account for the largest share of the global pharmaceutical excipients market. (outsourcing-pharma.com)
How do we make sure that the drug, or more specifically its added excipients, does not affect the delivery system's performance? (westpharma.com)
It can also enable an easier transition from vial system to PFS, since knowing whether or not a drug requires an excipient which is incompatible with, for example, silicone oil, will enable decisions on what type of syringe to use. (westpharma.com)
The growth can be attributed to the expanding pharmaceutical industry which has fueled the drug production thereby increasing consumption rate for excipients. (bharatbook.com)
Along with this new age, nanoparticle-based excipients are being developed to support nano-drug delivery methods. (pharmiweb.com)
The large number of advantages served by controlled drug release has created tremendous growth opportunities within the global sustained release excipients market. (tmrresearch.com)
The ability of sustained drug release to relieve patients of pain has created tremendous demand within the global market for sustained release excipients in recent times. (tmrresearch.com)
Furthermore, the advantages served by sustained drug release over conventional drugs are also expected to give an impetus to the growth of the global sustained release excipients market. (tmrresearch.com)
A key trend witnessed in the biologic excipients market is increasing adoption of continuous processing of biologic excipients, dependence of large drug manufacturers on in-house biologic excipients production, vast proportion of imported excipients leading to production delays, and regulatory harmonisation with respect to gradation of excipients. (marketresearchblog.org)
DRIFTS also may be used alphamox to investigate drug-excipient compatibility. (goldgreiner.de)
I am thrilled to start this new project, which aims to (i) quantify the presence of excipients in drugs available on the French market, (ii) estimate the French population exposure to these excipients through drug consumption, and (iii) investigate the potential relationship between titanium dioxide exposure from drugs and cancer risk. (who.int)

It is one of the few excipients available to improve viral stability for vaccines and gene therapies. (invitria.com)

Additionally, factors like functional excipients development and upsurge in generics market is also likely to propel market growth. (bharatbook.com)

For an individual manufacturer of an excipient product, there may be lot-to-lot variability of the physicochemical properties. (pharmtech.com)
Thus, physicochemical excipient-container interactions in prefilled syringes need to be understood to have a holistic view of their impact on syringe functionality. (westpharma.com)

There is no single-component excipient fulfills all the requisite performance to allow an active pharmaceutical ingredient to be formulated into a specific dosage form. (who.int)
Do not administer in case of hypersensitivity to the active substances or any of the excipients. (mybudgetpetstore.com)

Currently the largest data sharing consortium that Lhasa hosts, the Nitrites in Excipients database has seen significant growth since it's inception less than 2 years ago. (lhasalimited.org)
Some of the major factors contributing to the growth of the Asia Pacific market are low-cost manufacturing advantage, increasing per capita income, and low regulatory stringency that support the growth of the pharmaceutical excipients market in the region. (bharatbook.com)
In contrast, the market growth could substantially be hampered by tight rules and regulations regarding the negative environmental impacts of pharmaceutical excipients. (pharmiweb.com)
Moreover, the emergence of several stakeholders, angel investors, and venture capitalists who are willing to invest in the global sustained release excipients market has also given an impetus to the growth of this market. (tmrresearch.com)
A report on the global sustained release excipients market explains a multitude of factors that have contributed towards market growth in recent times. (tmrresearch.com)
The report is an inside account of the dynamics and forces that have played a defining role in the growth of the global sustained release excipients market. (tmrresearch.com)
The rise in the incidence of infectious and chronic diseases across the world has played a major role in the growth of the global sustained release excipients market. (tmrresearch.com)
Polymer biologic excipients account for the highest revenue share and are anticipated to witness a growth rate of 3.7% over the forecast period. (marketresearchblog.org)
The study analyzes crucial trends that are currently determining the growth of the pharmaceutical excipients market. (marketstatsnews.com)
Analysis of major countries, which hold growth opportunities or account for significant share has also been included as part of geographic analysis of the pharmaceutical excipients market. (marketstatsnews.com)

s adjective Etymology: Latin excipient , excipiens, present participle of excipere to take out, make an exception of, take, receive more at except : taking exception II. (en-academic.com)

Even for synthetic or semisynthetic excipient, differences in the feedstock, such as the organic and inorganic components from crude oil or gas, along with variability in chemical processing, will all contribute to the overall variability of the excipient product itself. (pharmtech.com)

Exbumin has been approved for use as an excipient in injectable therapeutics by regulatory agencies. (invitria.com)

In this article, Robertson offers insight on managing excipient variability in a QbD paradigm. (pharmtech.com)
Theoretical calculations based on Hansen Solubility Parameters (HSP) can provide insight into how much an excipient will interact with delivery system materials such as silicone oil. (westpharma.com)

Multidose vials used for injection, Excipients: Benzyl alcohol and H 2 O. (cdc.gov)

Excipient selection strongly influences lyophilization performance for biologic drugs. (biopharminternational.com)
In terms of revenue, the global biologic excipients market is projected to register a CAGR of 3.6% over the forecast period owing to various factors, regarding which FMI offers detailed insights and forecasts in this report. (marketresearchblog.org)
Biopharmaceutical manufacturers is the leading segment in the global biologic excipients market over the forecast period. (marketresearchblog.org)
Some of the key players featured in this report on the global biologic excipients market include BASF Corporation, FMC Corporation, Wacker Chemie AG, Evonik Industries AG, Ashland Global Holdings Inc., Archer-Daniels-Midland Co., Roquette Freres S.A., The Dow Chemical Company, Colorcon Inc., Signet Chemical Co. Pvt. (marketresearchblog.org)

Métodos: ensayo clínico aleatorizado, doble ciego, https://orcid.org/0000-0003-4003-1365 realizado con personas con diabetes tipo 2, en unidades de atención primaria de salud. (bvsalud.org)

However, excipients make up the bulk of drugs and medicines, making about 90% of each drug's composition. (nvronhealthcare.com)
Sustained dosing of drugs holds immense significance for a range of industries, and hence, the use of sustained release excipients has become more pronounced in recent times. (tmrresearch.com)
Excipients for modified release help in releasing drugs at a slow pace over an extended time period, and this helps in avoiding dose-dumping. (tmrresearch.com)

The dynamics of the market for sustained release excipients can be explained more deftly through an analysis of the aforementioned segments. (tmrresearch.com)
Besides this, the regional dynamics of the global sustained release excipients market have also been included in the report. (tmrresearch.com)
This report explicates on vital dynamics such as the drivers, restraints, and opportunities for key market players, along with key stakeholders as well as emerging players associated with the manufacturing of pharmaceutical excipients. (marketstatsnews.com)
The study also provides the dynamics that are responsible for influencing the future status of the pharmaceutical excipients market over the forecast period. (marketstatsnews.com)

We are into partnership with several renowned principals from across the globe to supply high quality Pharmaceuticals Excipients across India. (cphi-online.com)

Hence, the demand for sustained release excipients in the healthcare sector is expected to keep escalating in the years to come. (tmrresearch.com)

Excipient World is the leading education, networking and sourcing resource for the $6+ billion and growing global excipient market. (ashland.com)
Bolstered by manufacturing advancements, the global revenues of the pharmaceutical excipients market are expected to grow at a CAGR of 5.8% in the coming years. (outsourcing-pharma.com)
In 2019, the pharmaceutical excipients market is worth $6.97bn (€6.28bn), with its revenues expected to reach $9.79bn (€8.82bn) by 2025, according to research conducted by Markets and Markets. (outsourcing-pharma.com)
This report provides a detailed picture of the pharmaceutical excipients market. (bharatbook.com)
The demand within the global sustained release excipients market has been rising on account of key improvements in the pharmaceutical industry. (tmrresearch.com)
The global sustained release excipients market may be segmented on the basis of the following parameters: product, route of administration, technology, and region. (tmrresearch.com)
The global sustained release excipients market is projected to keep expanding over the forthcoming years. (tmrresearch.com)
The market for sustained release excipients in Asia Pacific has been expanding on account of the growing population across China and India. (tmrresearch.com)
Some of the key players in the global sustained release excipients market are Depomed, Inc. (tmrresearch.com)
The global market is segmented based on excipient type, end user and region. (marketresearchblog.org)
A detailed assessment of the pharmaceutical excipients market value chain analysis, business execution, and supply chain analysis across regional markets has been covered in the report. (marketstatsnews.com)
A list of prominent companies operating in the pharmaceutical excipients market along with their product portfolio enhances the reliability of this comprehensive research study. (marketstatsnews.com)
The report provides in-depth segment analysis of the global pharmaceutical excipients market, thereby providing valuable insights at macro as well as micro levels. (marketstatsnews.com)

Organisms3

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes13

Disciplines and Occupations2

Technology, Industry, Agriculture9

Health Care2

Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4. (1/728)

The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. (2/728)

A study of local anaesthetics. Part 148. Influence of auxiliary substances on the surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII. (3/728)

Beneficial effects of raxofelast (IRFI 016), a new hydrophilic vitamin E-like antioxidant, in carrageenan-induced pleurisy. (4/728)

Reduction of the cardiotoxicity of doxorubicin in rabbits and dogs by encapsulation in long-circulating, pegylated liposomes. (5/728)

Enhancement of solubilization and biodegradation of polyaromatic hydrocarbons by the bioemulsifier alasan. (6/728)

Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. (7/728)

Carrageenan primes leukocytes to enhance lipopolysaccharide-induced tumor necrosis factor alpha production. (8/728)

Excipients

Tablets

Chemistry, Pharmaceutical

Drug Compounding

Technology, Pharmaceutical

Powders

Dosage Forms

Drug Stability

Freeze Drying

Wettability

Emulsifying Agents

Pharmaceutic Aids

Cellulose

Delayed-Action Preparations

Lecithins

Solubility

Methylcellulose

Particle Size

Pharmaceutical Solutions

Preservatives, Pharmaceutical

Thermogravimetry

Monoglycerides

Drug Storage

Pharmaceutical Preparations

Povidone

Desiccation

Lubricants

Calorimetry, Differential Scanning

Cyperus

Poloxalene

Hardness

Dry Powder Inhalers

Humidity

Powder Diffraction

Mannitol

Tanacetum parthenium

Starch

Emulsions

Stearic Acids

Drug Carriers

Drug Delivery Systems

Laurates

Hardness Tests

Terminalia

Capsules

Flavoring Agents

Carboxymethylcellulose Sodium

Chitosan

Polysorbates

Polymers

Tablets, Enteric-Coated

Methylene Chloride

Insulin, Short-Acting

Polyethylene Glycols

Tensile Strength

Propylene Glycol

Viscosity

Water

Phase Transition

Pseudoephedrine

Lactose

Polyglactin 910

Resins, Plant

Porosity

Magnesium Silicates

Biological Availability

Benzyl Alcohol

Drug Contamination

Administration, Buccal

Organic Chemistry Phenomena

Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4. (1/728)

The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. (2/728)

A study of local anaesthetics. Part 148. Influence of auxiliary substances on the surface tension, distribution coefficient and pharmaceutical availability from solutions of the potential drug VII. (3/728)

Beneficial effects of raxofelast (IRFI 016), a new hydrophilic vitamin E-like antioxidant, in carrageenan-induced pleurisy. (4/728)

Reduction of the cardiotoxicity of doxorubicin in rabbits and dogs by encapsulation in long-circulating, pegylated liposomes. (5/728)

Enhancement of solubilization and biodegradation of polyaromatic hydrocarbons by the bioemulsifier alasan. (6/728)

Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. (7/728)

Carrageenan primes leukocytes to enhance lipopolysaccharide-induced tumor necrosis factor alpha production. (8/728)

Effects of selected pharmaceutical excipients on drug permeation at different gastro-intestinal tract regions

Pharmaceutical Excipients Market to Surpass US$ 7,415.2 Mn by 2021 - BizPR.us | US Free Press Release and Distribution center