A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
A ubiquitous hnRNP protein found in the CELL NUCLEUS and the CYTOPLASM. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS may play a role in neoplastic processes such as EWING SARCOMA.
A member of the c-ets family of transcription factors that is preferentially expressed in cells of hematopoietic lineages and vascular endothelial cells. It was originally identified as a protein that provides a retroviral integration site for integration of FRIEND MURINE LEUKEMIA VIRUS.
Tumors or cancer located in bone tissue or specific BONES.
A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)
The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.
A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)
A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
A group of highly cellular primitive round cell neoplasms which occur extracranially in soft tissue and bone and are derived from embryonal neural crest cells. These tumors occur primarily in children and adolescents and share a number of characteristics with EWING SARCOMA.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Group of alpharetroviruses (ALPHARETROVIRUS) producing sarcomata and other tumors in chickens and other fowl and also in pigeons, ducks, and RATS.
Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.
Neoplasms located in the space between the vertebral PERIOSTEUM and DURA MATER surrounding the SPINAL CORD. Tumors in this location are most often metastatic in origin and may cause neurologic deficits by mass effect on the spinal cord or nerve roots or by interfering with blood supply to the spinal cord.
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
A group of replication-defective viruses, in the genus GAMMARETROVIRUS, which are capable of transforming cells, but which replicate and produce tumors only in the presence of Murine leukemia viruses (LEUKEMIA VIRUS, MURINE).
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
Diamond nanoparticles that exhibit unique biological, thermal, mechanical, and optoelectronic properties. They have important NANOMEDICINE applications including DRUG DELIVERY SYSTEMS; DIAGNOSTIC IMAGING; protein separation; and BIOSENSING TECHNIQUES.
A cell line derived from cultured tumor cells.
A type I keratin found associated with KERATIN-6 in rapidly proliferating squamous epithelial tissue. Mutations in the gene for keratin-17 have been associated with PACHYONYCHIA CONGENITA, TYPE 2.
Proteins which bind calmodulin. They are found in many tissues and have a variety of functions including F-actin cross-linking properties, inhibition of cyclic nucleotide phosphodiesterase and calcium and magnesium ATPases.
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
Connective tissue tumors, affecting primarily fowl, that are usually caused by avian sarcoma viruses.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
The locations in specific DNA sequences where CHROMOSOME BREAKS have occurred.
Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.
A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
The MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body.
An extramedullary tumor of immature MYELOID CELLS or MYELOBLASTS. Granulocytic sarcoma usually occurs with or follows the onset of ACUTE MYELOID LEUKEMIA.
A highly malignant subset of neoplasms arising from the endometrial stroma. Tumors in this group infiltrate the stroma with a wide range of atypia cells and numerous mitoses. They are capable of widespread metastases (NEOPLASM METASTASIS).
A sarcoma of young, often female, adults of the lower extremities and acral regions, intimately bound to tendons as circumscribed but unencapsulated melanin-bearing tumors of neuroectodermal origin. An ultrastructural finding simulates flattened and curved barrel staves, corresponding to the internal structures of premelanosomes. There is a 45-60% mortality in clear cell sarcoma. (Segen, Dictionary of Modern Medicine, 1992)
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.
A enzyme complex involved in the remodeling of NUCLEOSOMES. The complex is comprised of at least seven subunits and includes both histone deacetylase and ATPase activities.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
A replication-defective murine sarcoma virus (SARCOMA VIRUSES, MURINE) capable of transforming mouse lymphoid cells and producing erythroid leukemia after superinfection with murine leukemia viruses (LEUKEMIA VIRUS, MURINE). It has also been found to transform cultured human fibroblasts, rat liver epithelial cells, and rat adrenocortical cells.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A replication-defective murine sarcoma virus (SARCOMA VIRUSES, MURINE) isolated from a rhabdomyosarcoma by Moloney in 1966.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Species of GAMMARETROVIRUS isolated from fibrosarcoma in cats. The viruses are actually recombinant feline leukemia viruses (FeLV) where part of the genome has been replaced by cellular oncogenes. It is unique to individuals and not transmitted naturally to other cats. FeSVs are replication defective and require FeLV to reproduce.
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage. Adv. Exp. Med. Biol. Advances in Experimental Medicine and ... "Entrez Gene: EWSR1 Ewing sarcoma breakpoint region 1". "EWS family fusion genes - OMIM". Anderson ND, de Borja R, Young MD, ... Ouchida M, Ohno T, Fujimura Y, Rao VN, Reddy ES (September 1995). "Loss of tumorigenicity of Ewing's sarcoma cells expressing ... Thomas GR, Latchman DS (2002). "The pro-oncoprotein EWS (Ewing's Sarcoma protein) interacts with the Brn-3a POU transcription ...
"EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage". Advances in Experimental Medicine and Biology. 587: 41-52. ... December 1993). "The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more ... In pediatric Ewing's sarcoma a chromosomal translocation generates a fusion of the 5' transactivation domain of EWSR1 (also ... translocation junction in a case of Ewing's sarcoma". Genes, Chromosomes & Cancer. 13 (2): 126-32. doi:10.1002/gcc.2870130209. ...
"An integrated analysis of miRNA and gene copy numbers in xenografts of Ewing's sarcoma". Journal of Experimental & Clinical ...
"In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type". Oncogene. 24 ... Perbal B (2006). "The CCN3 protein and cancer". Advances in Experimental Medicine and Biology. 587: 23-40. doi:10.1007/978-1- ... "Prognostic relevance of CCN3 in Ewing sarcoma". Human Pathology. 40 (10): 1479-86. doi:10.1016/j.humpath.2009.05.008. PMID ... expression is associated with a higher risk of metastasis and worse prognosis in patients with cancers such as Ewing's sarcoma ...
James Ewing 1888, namesake of Ewing's Sarcoma; eminent experimental oncologist; helped found progenitor of the American Cancer ... Prize Physicist Henry Way Kendall 1950, experimental work provided first evidence of quarks and quark model Microbiologist Carl ... of Physics, a leading experimental physicist in his era Anthony Lake, Prof. of International Relations, 1981-1984, former ... experimental physics), Kolos Medal (chemistry) (2005), and Benjamin Franklin Medal in Physics (2006) Translator and poet Robert ...
Ethylmalonic adipic aciduria Euhidrotic ectodermal dysplasia Eumycetoma Eunuchoidism familial Evan's syndrome Ewing's sarcoma ... type 3 Exostoses Exotropia Experimental allergic encephalomyelitis Exploding head syndrome Exstrophy of the bladder Exstrophy ... infective Endocarditis Endocrinopathy Endometrial stromal sarcoma Endometriosis Endomyocardial fibroelastosis Endomyocardial ...
Ewing, J., & Beebe, S. P. (1906). A study of the so-called infectious lympho-sarcoma of dogs. Journal of Med. Research. 10:209. ... James Ewing a leading pathologist working at the Loomis Laboratory for Research in Experimental Pathology. The Loomis ... Ewing, J., & Beebe, S. P. (1906). A study of the so-called infectious lympho-sarcoma of dogs. Journal of Med. Research. 10:209 ... The Journal of experimental medicine, 7(6): 733-750. Beebe, S. P., and Philip Shaffer. (1905). "The chemistry of malignant ...
... and the Ewing's sarcoma family of tumors. A member of the NCAM superfamily, NCAM2 gene has been observed progressively ... NCAM has been used as a target molecule for experimental antibody-based immunotherapy. Successful radio-immunolocalisation of ...
"The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology ... The Journal of Experimental Medicine. 182 (3): 801-810. doi:10.1084/jem.182.3.801. PMC 2192167. PMID 7650486. Auffray C, Behar ... an in frame fusions product between EWSR1 gene and the NFATc2 gene has been described in bone tumor with a Ewing sarcoma-like ... Advances in Experimental Medicine and Biology. 365: 167-73. doi:10.1007/978-1-4899-0987-9_17. ISBN 978-1-4899-0989-3. PMID ...
Metastatic Ewing's cell sarcoma of the sinus and osteoid osteoma of the orbit. American Journal of Ophthalmology. 123(4): 565- ... Graefe's Archive for Clinical and Experimental Ophthalmology. 244 (4): 529-531. doi:10.1007/s00417-005-0132-2. ISSN 0721-832X. ... Chynn, E. W.; Rubin, P. A. (April 1997). "Metastatic Ewing cell sarcoma of the sinus and osteoid osteoma of the orbit". ...
Cellular based (T cells, NK cells and DC) therapy in children with neuroblastoma and Ewing sarcoma. Prof. Michael Nishimura, ... Differences in monocyte phenotypes induced by cultivation on glass or on collagen". Journal of Experimental Medicine. 156 (4): ...
Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on ... Experimental Cell Research. 312 (7): 1194-204. doi:10.1016/j.yexcr.2006.02.001. PMID 16510139. ZNF384+protein,+human at the US ... "Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in ...
"Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite". Nature Genetics. 47 (9): ... Clinical and Experimental Immunology. 138 (1): 1-9. doi:10.1111/j.1365-2249.2004.02592.x. PMC 1809191. PMID 15373898. Lander ES ... non-coding genetic polymorphisms contribute to susceptibility to Ewing sarcoma, an aggressive pediatric bone cancer. Some ... Clinical and Experimental Pharmacology & Physiology. 35 (4): 372-5. doi:10.1111/j.1440-1681.2008.04880.x. PMID 18307723. S2CID ...
... and in Ewing's sarcoma, FEN1 is over-expressed in the majority of cancers of the breast, prostate, stomach, neuroblastomas, ... Advances in Experimental Medicine and Biology. 937: 109-22. doi:10.1007/978-3-319-42059-2_6. ISBN 978-3-319-42057-8. PMID ... polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells". Oncol. Rep. 9 (3): 529-32. ... Advances in Experimental Medicine and Biology. 754: 3-29. doi:10.1007/978-1-4419-9967-2_1. ISBN 978-1-4419-9966-5. PMC 3707278 ...
Jaffe N, Paed D, Traggis D, Salian S, Cassady JR (November 1976). "Improved outlook for Ewing's sarcoma with combination ... Proceedings of the Society for Experimental Biology and Medicine. 45: 609-614. doi:10.3181/00379727-45-11768. S2CID 84774334. ... This includes Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, trophoblastic neoplasm, testicular cancer, and certain types of ... tumor Rhabdomyosarcoma Ewing's sarcoma Malignant hydatidiform mole Sometimes it will be combined with other drugs in ...
Ewing, James. (1922). Neoplastic diseases: a treatise on tumors. WB Saunders Company. Pritchard, J. E. (1927). "EWING'S SARCOMA ... With his discoveries using that research funding, Ewing became the most important experimental oncologist and helped to found, ... Ewing's sarcoma. In 1931 Ewing was formally appointed president of the hospital and was featured on the cover of Time Magazine ... Ewing, James & Beebe, S. P. (1906). A study of the so-called infectious lympho-sarcoma of dogs. Journal of Med. Research. 10: ...
... sarcoma, experimental MeSH C04.557.450.795.830.760 - sarcoma 37 MeSH C04.557.450.795.830.780 - sarcoma 180 MeSH C04.557.450.795 ... sarcoma, ewing's MeSH C04.557.450.795.650 - phyllodes tumor MeSH C04.557.450.795.775 - sarcoma, alveolar soft part MeSH C04.557 ... sarcoma 37 MeSH C04.619.857.656 - sarcoma 180 MeSH C04.619.857.800 - sarcoma, avian MeSH C04.619.857.822 - sarcoma, yoshida ... sarcoma, clear cell MeSH C04.557.450.565.825 - sarcoma, small cell MeSH C04.557.450.565.835 - sarcoma, synovial MeSH C04.557. ...
Two variants of a disease associated with ETV4 is Ewing Sarcoma and Extraosseous Ewing's Sarcoma. While both are cancerous ... Experimental Metastasis. 21 (3): 191-9. doi:10.1023/B:CLIN.0000037703.37275.35. PMID 15387369. S2CID 22579184. Fauquette V, ... in extraosseous Ewing's sarcoma". Biochemical and Biophysical Research Communications. 219 (2): 608-12. doi:10.1006/bbrc. ...
... is significantly overexpressed in the Wnt signaling-dependent subgroup of medulloblastoma, as well as in ewing sarcomas ... Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: ... "G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1". The Journal of ...
... eponymist of Ewing's sarcoma, one of the founders of AACR. Robert (Robin) Sanno Fåhræus (1888-1968), Swedish pathologist (see ... Ludwig Traube (1818-1876), German physician, co-founder of the experimental pathology in Germany. Václav Treitz (1819-1872), ... Jakob Erdheim (1874-1937), Austrian pathologist (see Erdheim-Chester disease). James Ewing (1866-1943), American surgical ... Maud Slye (1879-1954), American experimental pathologist. Theobald Smith (1859-1934), American pioneering epidemiologist and ...
... epithelioid sarcoma, Ewing's sarcoma, synovial sarcoma, sacrococcygeal teratoma, liposarcoma), melanoma Severe limb injuries in ... An experimental technique known as the "Ewing amputation" aims to improve post-amputation proprioception. In 1920, Professor ... How The Marathon Bombing Helped Bring Innovation To Amputation Jim Ewing, Dynamic-Model Amputation Patient "Ertl Reconstruction ...
In Ewing's sarcoma (a type of painful bone cancer in young humans), a point mutation has created an extended GGAA ... "Experimental evaluation of the usefulness of microsatellite DNA for detecting demographic bottlenecks". Molecular Ecology. 9 ... "Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite". Nature Genetics. 47 (9): ...
Ewing's sarcoma. Victoria Rodríguez, 88, Spanish actress, pneumonia. Ana Romero Reguera, 88, Spanish fighting bull rancher. ... Cor Fuhler, 55, Dutch-Australian experimental musician. Mikołaj Kubica, 74, Polish Olympic gymnast (1964, 1968, 1972). Ildikó ... America's Experimental Poet of Light and Neon, Has Died at Age 78 Baba Ibrahim Suma-Keita Fallece el navarro Lucio Urtubia, ...
Ewing's sarcoma and Angelman's syndrome. In addition, topotecan is experimentally treating Non-small cell lung cancer, ... Experimental Cell Research. 211 (2): 314-21. doi:10.1006/excr.1994.1093. PMID 8143779. "FDA Rubber-Stamps APP Pharma's Generic ...
... and Ewing sarcoma. In addition, in preclinical studies using cells in culture or within mice, PARP1 inhibitors are being tested ... Budding yeast has many experimental advantages in screens, including a small genome, fast doubling time, both haploid and ...
In Ewing's sarcoma (a type of painful bone cancer in young humans), a point mutation has created an extended GGAA ... doi:10.1016/S0169-5347(03)00008-9. Spencer CC, Neigel JE, Leberg PL (October 2000). "Experimental evaluation of the usefulness ... September 2015). "Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite". Nature ... other GGAA microsatellites may influence the expression of genes that contribute to the clinical outcome of Ewing sarcoma ...
A negative CD34 may exclude Ewing's sarcoma/PNET, myofibrosarcoma of the breast, and inflammatory myofibroblastic tumors of the ... Nakamura Y, Komano H, Nakauchi H (Feb 1993). "Two alternative forms of cDNA encoding CD34". Experimental Hematology. 21 (2): ... granulocytic sarcoma, Kaposi's sarcoma, liposarcoma, malignant fibrous histiocytoma, malignant peripheral nerve sheath tumors, ... In tumors, CD34 is found in alveolar soft part sarcoma, preB-ALL (positive in 75%), AML (40%), AML-M7 (most), ...
Also, betulinic acid was found active in vitro against neuroectodermal (neuroblastoma, medulloblastoma, Ewing's sarcoma) and ... The Journal of Pharmacology and Experimental Therapeutics. 289 (3): 1306-12. PMID 10336521. Thurnher D, Turhani D, Pelzmann M, ...
... and Ewing sarcoma, the latter two being bone tumours. Chromothripsis has been seen in 2-3% of cancers across all subtypes. ... In 2015, several research groups presented experimental evidence that chromothripsis is indeed caused by a single catastrophic ... sarcomas and colorectal, lung and thyroid cancers. In subsequent investigations, about 25% of studied bone cancers displayed ...
Ewing's sarcoma, and osteosarcoma, and expression of the EZH2 component of the PRC2 complex is altered in Ewing's sarcoma and ... Two broad experimental survey articles also document most of these epigenetic DNA repair deficiencies in cancers. Red- ... Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Drug targeting and inhibition of EZH2 in Ewing's sarcoma, or of LSD1 in ... Ewing's sarcoma, leiomyosarcoma, liposarcoma, osteosarcoma, synovial sarcoma, and (alveolar and embryonal) rhabdomyosarcoma. ...
Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease, Hodgkin's disease and Wiskott-Aldrich ... Clinical and Experimental Rheumatology. 34 (4 Suppl 98): 53-57. ISSN 0392-856X. PMID 27586805.. ...
Ewing's sarcoma t(11 FLI1; 22 EWS). *Synovial sarcoma t(x SYT;18 SSX) ... Use in experimental biology[edit]. Genetic mosaics can be extraordinarily useful in the study of biological systems, and can be ... "A new behavioral bioassay for an analysis of sexual attraction and pheromones in insects". Journal of Experimental Zoology. 192 ...
Early sarcoma patientsEdit. In 1890, Coley began his first year of private practice at New York Hospital and met Elizabeth ... James Ewing, a famed cancer pathologist at the time, was one of Coley's biggest critics. A leader in the field of oncology at ... Since its changed status under the FDA, it has only been able to be prescribed through experimental clinical trials, which have ... Treatment for sarcoma at the time was scarce; the most widely accepted form of treatment was a complete amputation of the ...
Ewing's sarcoma t(11 FLI1; 22 EWS). *Synovial sarcoma t(x SYT;18 SSX) ... Bianchi DW, Wilkins-Haug LE, Enders AC, Hay ED (June 1993). "Origin of extraembryonic mesoderm in experimental animals: ...
Ewing's sarcoma t(11 FLI1; 22 EWS). *Synovial sarcoma t(x SYT;18 SSX) ... "Journal of Experimental Medicine. 179 (6): 1855-1865. doi:10.1084/jem.179.6.1855. PMC 2191514.. ...
... eponymist of Ewing's sarcoma, one of the founders of AACR. ... co-founder of the experimental pathology in Germany. ... James Ewing (1866-1943), American surgical pathologist, first professor of Pathology at Cornell University, ... Maud Slye (1879-1954), American experimental pathologist.. *Theobald Smith (1859-1934), American pioneering epidemiologist and ... Sharon Weiss (born 1945), American surgical pathologist, expert on soft tissue pathology (see Sarcoma). ...
A negative CD34 may exclude Ewing's sarcoma/PNET, myofibrosarcoma of the breast, and inflammatory myofibroblastic tumors of the ... Nakamura Y, Komano H, Nakauchi H (Feb 1993). "Two alternative forms of cDNA encoding CD34". Experimental Hematology. 21 (2): ... granulocytic sarcoma, Kaposi's sarcoma, liposarcoma, malignant fibrous histiocytoma, malignant peripheral nerve sheath tumors, ... In tumors, CD34 is found in alveolar soft part sarcoma, preB-ALL (positive in 75%), AML (40%), AML-M7 (most), ...
Ewing's sarcoma t(11 FLI1; 22 EWS). *Synovial sarcoma t(x SYT;18 SSX) ... "International Journal of Clinical and Experimental Pathology. 8 (2): 2090-102. PMC 4396324. PMID 25973110.. ...
Ewing's sarcoma. Central Nervous System. Idiopathic pain syndromes. Local. Complex regional pain syndrome/Reflex sympathetic ... there is experimental evidence that demonstrates NMDA receptors in peripheral nerves.[22] Because immunological functions can ...
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, ... Experimental Cell Research. 313 (18): 3832-9. doi:10.1016/j.yexcr.2007.08.017. PMID 17904119.. ... "Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma". Proceedings of the National Academy of ... of a constitutively active Rac1 V12 in mice caused a tumor that's phenotypically indistinguishable from human Kaposi's sarcoma. ...
... discovery of a form of malignant bone tumor that later became known as Ewing's Sarcoma Don W. Fawcett (chair of the Department ... American experimental psychologist and a recipient of the National Medal of Science (1964) Ulrich Neisser (Professor) - studied ... James Ewing Alumni Professor of Pathology (1991-1999, later Adjunct Professor of Pathology at the Weill Cornell Medical College ... Fellow of the Society of Experimental Psychologists, the American Academy of Arts and Sciences and of the American Association ...
Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc ... Introduced Bacille Calmette-Guérin (BCG), the tuberculosis vaccine, into experimental cancer research as a way to stimulate non ... James Ewing Society 1972: Lecturer, The Harvey Society of New York 1972: Louis Gross Award 1974: Member, Institute of Medicine ... 1964 Dec 5;2(7371): 1207-9. Old LJ, Boyse EA, Stockert E. Antigenic properties of experimental leukemias. I. Serological ...
James Ewing, a famed cancer pathologist at the time, was one of Coley's biggest critics. A leader in the field of oncology at ... Treatment for sarcoma at the time was scarce; the most widely accepted form of treatment was a complete amputation of the ... Since its changed status under the FDA, it has only been able to be prescribed through experimental clinical trials, which have ... Coley decided to review and research similar cases of sarcoma in the medical files at New York Hospital, where he found a case ...
Brennan later determines that he has Ewing's sarcoma, a rare bone cancer. Initially, Wendell wants to give up his work and ... She often gets into conflict with Cam and Bones because she uses experimental scientific techniques and tends to not ask for ...
Ewing's sarcoma, liposarcoma, fibrosarcoma, leiomyosarcoma and other soft tissue sarcomas. It is not usually expressed on the ... Experimental work indicates that the Fc portion of cancer immunotherapy drugs can affect the outcome of treatment. For example ... McCarthy EF (2006). "The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas". The Iowa Orthopaedic ... Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic ...
The treatment paired two chemotherapy drugs currently used to treat Ewing sarcoma (EWS) with experimental drugs called poly-ADP ... Experimental breast cancer drug holds promise in combination therapy for Ewing sarcoma. ... Ewing sarcoma tumors disappeared and did not return in more than 70 percent of mice treated with combination therapy that ... "During the past 20 years there has been no significant improvement in the cure rate for Ewing sarcoma, and survival is just 15 ...
... researchers have identified a promising new triple-drug combination therapy that exploits DNA repair problem in Ewing sarcoma ... Experimental breast cancer drug holds promise in combination therapy for Ewing sarcoma Memphis, Tennessee, October 23, 2014 ... The treatment paired two chemotherapy drugs currently used to treat Ewing sarcoma (EWS) with experimental drugs called poly-ADP ... Ewing sarcoma tumors disappeared and did not return in more than 70 percent of mice treated with combination therapy that ...
Experimental: Vigil + Irinotecan and Temozolomide Group A Schedule:. Temozolomide 100 mg/m2 daily, oral, Days 1 - 5, every 21 ... Ewing Sarcoma Ewing Family of Tumors Ewings Tumor Metastatic Ewings Sarcoma Metastatic Ewings Tumor Recurrent Rare Diseases ... Sarcoma, Ewing. Sarcoma. Neoplasms by Histologic Type. Neuroectodermal Tumors, Primitive, Peripheral. Neoplasms, Connective and ... Genetic and Rare Diseases Information Center resources: Soft Tissue Sarcoma Ewing Sarcoma Neuroepithelioma Osteosarcoma ...
Experimental: Olaparib 400mg PO BID Continuous. Drug: Olaparib 400mg PO BID Continuous ... Genetic and Rare Diseases Information Center resources: Soft Tissue Sarcoma Ewing Sarcoma Ewing's Family of Tumors ... Sarcoma. Sarcoma, Ewing. Neoplasms, Connective and Soft Tissue. Neoplasms by Histologic Type. Neoplasms. Osteosarcoma. ... Olaparib in Adults With Recurrent/Metastatic Ewings Sarcoma. The safety and scientific validity of this study is the ...
Experimental: INCB059872 INCB059872. Drug: INCB059872 Part 1: Initial cohort of INCB059872 administered every other day (QOD) ... Sarcoma. Sarcoma, Ewing. Neoplasms, Connective and Soft Tissue. Neoplasms by Histologic Type. Neoplasms. Osteosarcoma. ... Genetic and Rare Diseases Information Center resources: Soft Tissue Sarcoma Ewing Sarcoma Osteosarcoma ... A Study of INCB059872 in Relapsed or Refractory Ewing Sarcoma. The safety and scientific validity of this study is the ...
Experimental: Arm I See detailed description.. Biological: filgrastim. Drug: amifostine trihydrate. Drug: cyclophosphamide. ... Genetic and Rare Diseases Information Center resources: Soft Tissue Sarcoma Granulocytopenia Ewing Sarcoma Ewing's Family ... I. Evaluate the response rate and duration of response of patients with newly diagnosed, metastatic Ewings sarcoma or ... WR-2721 (amifostine) infusion in patients with Ewings sarcoma receiving ifosfamide and cyclophosphamide with mesna: drug and ...
EXPERIMENTAL DESIGN: We performed a genome-scale open-reading frame (ORF) screen in two Ewing cell lines sensitive to CDK4/6i ... CONCLUSIONS: Taken together, these results suggest that IGF1R activation is an escape mechanism to CDK4/6i in Ewing sarcoma and ... The cyclin-dependent kinase (CDK)4/6 pathway recently emerged as a dependency in Ewing sarcoma, an aggressive pediatric ... We also found elevated levels of phospho-IGF1R in our resistant Ewing cell line, supporting the relevance of IGF1R signaling to ...
Park YK, Chi SG, Kim YW, Park HR, Unni KK: P53 mutations in Ewings sarcoma. Oncol Rep. 2001, 8: 533-537.PubMedGoogle Scholar. ... von Levetzow C, Jiang X, Gwye Y, von Levetzow G, Hung L, Cooper A, Hsu JH, Lawlor ER: Modeling initiation of Ewing sarcoma in ... Huang HY, Illei PB, Zhao Z, Mazumdar M, Huvos AG, Healey JH, Wexler LH, Gorlick R, Meyers P, Ladanyi M: Ewing sarcomas with p53 ... Huang HY, Illei PB, Zhao Z, Mazumdar M, Huvos AG, Healey JH, Wexler LH, Gorlick R, Meyers P, Ladanyi M: Ewing sarcomas with p53 ...
... young people and adults with Ewings sarcoma who already had treatment. ... Experimental Cancer Medicine Centre (ECMC). NIHR Clinical Research Network: Cancer. University College London (UCL). Medac. The ... Ewings sarcoma is a type of cancer that usually develops in, or near, the bones. It mainly affects teenagers, young adults and ... Doctors usually treat Ewings sarcoma with chemotherapy. But if the tumour does not completely disappear, or continues to grow ...
Experimental: Single Arm Palbociclib in combination with temozolomide and irinotecan. Interventions:*Drug: Palbociclib ... Solid Tumors, Ewing Sarcoma, Rhabdoid Tumor, Rhabdomyosarcoma, Neuroblastoma, Medulloblastoma, Diffuse Intrinsic Pontine Glioma ... Solid Tumors, Ewing Sarcoma, Rhabdoid Tumor, Rhabdomyosarcoma, Neuroblastoma, Medulloblastoma, Diffuse Intrinsic Pontine Glioma ... For dose expansion cohort: Histologically confirmed solid tumor including but not limited to Ewing sarcoma, rhabdoid tumor, ...
... including Ewing sarcoma, remain recalcitrant. To broaden the therapeutic landscape, we explored the in vitro response of Ewing ... Experimental Design: Drugs displaying activity as single agents were evaluated in combinatorial (matrix) format to identify ... Inhibitors in Ewing Sarcoma. Christine M. Heske, Mindy I. Davis, Joshua T. Baumgart, Kelli Wilson, Michael V. Gormally, Lu Chen ... Inhibitors in Ewing Sarcoma. Christine M. Heske, Mindy I. Davis, Joshua T. Baumgart, Kelli Wilson, Michael V. Gormally, Lu Chen ...
Experimental and Molecular Therapeutics Abstract 3453: Selective sensitivity of Ewings Sarcoma to the PARP inhibitor BMN 673. ... Selective sensitivity of Ewings Sarcoma to the PARP inhibitor BMN 673. [abstract]. In: Proceedings of the 104th Annual Meeting ... Results: BMN 673 had a potent anti-proliferative activity in low nanomolar range with 20/24 Ewings sarcoma lines demonstrating ... Abstract 3453: Selective sensitivity of Ewings Sarcoma to the PARP inhibitor BMN 673. ...
Experimental Breast Cancer Drug Could Work for Ewing Sarcoma. A combination therapy that included drugs from a family of ... Two Mutations Linked to Ewing Sarcoma Subtype With Poor Prognosis. Frequent mutations in two genes that often occur together in ... experimental agents developed to fight breast cancer was administered on mice with Ewing sarcoma tumors. ... Kaposis Sarcoma Treatment Gets a New Clue. The search for an efficient treatment for a type of cancer-causing herpes, known as ...
... in patients with sarcoma and Ewings sarcoma: a phase 1 expansion cohort study. Lancet Oncol 2009;11:129-35. ... Experimental Design: Patients received cixutumumab, 6 mg/kg i.v. weekly, and temsirolimus, 25 to 37.5 mg i.v. weekly (4-week ... Efficacy of and resistance to anti-IGF-1R therapies in Ewings sarcoma is dependent on insulin receptor signaling. Oncogene ... Phase II Trial of anti-IGF-1R antibody cixutumumab in patients with advanced or metastatic soft-tissue sarcoma and Ewing family ...
Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. Int J Oncol. 2004; 25: 549-553.. * ... Angiogenesis and Ewing sarcoma-relationship to pulmonary metastasis and survival. J Pediatr Surg. 2006; 41: 524-529.. *CrossRef ... Impact of IGF-I/IGF-IR circuit on the angiogenetic properties of Ewings sarcoma cells. Horm Metab Res. 2003; 35: 675-684.. * ... Preclinical evaluation of vascular-disrupting agents in Ewings sarcoma family of tumours. Eur J Cancer. 2009; 45: 713-722.. * ...
To exploit our observation that GSTM4 expression is specifically up-regulated in Ewing sarcoma, we tested the effect of a GSTM4 ... To exploit our observation that GSTM4 expression is specifically up-regulated in Ewing sarcoma, we tested the effect of a GSTM4 ... Our data suggest that GSTM4 is a novel therapeutic target for the treatment of high GSTM4-expressing Ewing sarcoma. Strategies ... We found that JS-K robustly decreased Ewing sarcoma cell viability and xenograft tumor growth, and improved overall survival of ...
Experimental Therapeutics, Molecular Targets, and Chemical Biology A Pivotal Role for Heat Shock Protein 90 in Ewing Sarcoma ... Potential use of imatinib in Ewings Sarcoma: evidence for in vitro and in vivo activity. J Natl Cancer Inst 2002; 94: 1673-9. ... Ewing Sarcoma (ES) is a neoplasm affecting children and young adults, in which 5-year survival rates remain around 70% ( 1, 2 ... The metastatic ability of Ewings sarcoma cells is modulated by stem cell factor and by its receptor c-kit. Am J Pathol 2000; ...
This trial is looking at 4 different types of chemotherapy to treat Ewings sarcoma that didnt respond to treatment or has ... Have had chemotherapy or an experimental drug in the last 2 weeks ... Have Ewings sarcoma that didnt respond to the treatment you ... Doctors can treat Ewings sarcoma with surgery, chemotherapy or radiotherapy. If Ewings sarcoma doesnt respond to these ... Ewings sarcoma is a type of cancer that mainly affects teenagers, young adults and children. This trial is for both adults and ...
Ewing tumor; Neuroepithelioma; Peripheral primitive neuroectodermal tumor Aggressive small round cell tumor affecting bone and ... This process is experimental and the keywords may be updated as the learning algorithm improves. ... Ewing Sarcoma Small Round Cell Ewing Sarcoma Cell Peripheral Primitive Neuroectodermal Tumor Ewing Sarcoma Family Tumor These ... Today, all these neoplasms are summarized as Ewing tumors (ET) or Ewing sarcoma family tumors (ESFT). Although first described ...
Therapy was well tolerated, and the 5-year EFS for 35 patients was 80%. This pilot study became the experimental arm of COG- ... Ewing sarcoma/peripheral primitive neuroectodermal tumor (PNET). Cellular Classification of Ewing Sarcoma. Ewing sarcoma ... Ewing sarcoma of chest wall), and extraosseous Ewing sarcoma (often combined in the term Ewing sarcoma family of tumors) refer ... Sarcoma: Bone Sarcoma: Ewing Sarcoma: Soft Tissue Sarcomas Skin Cancers Small Bowel Cancers Small Cell Lung Cancer ...
Ewings sarcoma. A tumor of the bone.. Free radicals. Chemical compounds that are byproducts of metabolism which damage cells ... Permits granted by the Food and Drug Administration for the use of new drugs with patients on an experimental basis. ... Sarcoma. A neoplasm arising from the connective tissue, including bone, blood, muscle, fat, and lymph vessels. ...
YK-4-279-resistant TC71 Ewing sarcoma clone #3 was selected for the remaining experimental investigations rather than TC71#4A ... This implies that Ewing sarcoma adapted to YK-4-279 by altering the molecular machinery required for Ewing sarcoma survival and ... Ewing sarcoma family of tumors, which encompass traditional Ewing sarcoma of bone (1), primitive neuroectodermal tumors (PNET; ... Ewing sarcoma acquired resistant clones generation. TC32 and TC71 Ewing sarcoma YK-4-279 acquired resistant clones were ...
... of IGF-1R and other signaling molecules as an effective strategy to combat acquired drug resistance by carcinomas and sarcomas. ... Windsor, R.; Strauss, S.; Seddon, B.; Whelan, J. Experimental therapies in Ewings sarcoma. Expert. Opin. Investig. Drugs 2009 ... Targeting the Insulin-Like Growth Factor 1 Receptor in Ewings Sarcoma: Reality and Expectations. Sarcoma 2011, 2011, 402508. [ ... Merchant, M.S.; Woo, C.W.; Mackall, C.L.; Thiele, C.J. Potential use of imatinib in Ewings Sarcoma: evidence for in vitro and ...
Ewing sarcoma is the second most common pediatric bone malignancy. It is initiated by chromosomal translocation t(11;22)(q24; ... researchers describe two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma ... Lessnick and his team used bioinformatics analysis of experimental data in an unbiased genome-wide approach. Then, they ... Ewing sarcoma is the second most common pediatric bone malignancy. It is initiated by chromosomal translocation t(11;22)(q24; ...
Ewings sarcoma family of tumors : current management BERNSTEIN M Oncologist. 11(5), 503-519, 2006 ... 電気穿孔法を用いた塩酸ドキソルビシンのハムスター口腔線維肉腫に対する抗腫瘍効果の実験的研究 [in Japanese] Experimental Study of Antitumor Effects of Doxorubicin Hydrochoride ... Electrochemotherapy for the treatment of human sarcoma in athymic rats JAROSZESKI MJ ... Intraoperative versus postoperative electrochemotherapy in
Ewing sarcoma is a cancer of the bone or soft tissue that usually affects children and young adults. Explore symptoms, ... targeted treatments such as immunotherapy are considered experimental for patients with Ewing sarcoma. Doctors may pursue ... What is Ewing sarcoma?. Ewing sarcoma is cancer that occurs primarily in the bone or soft tissue. While Ewing sarcoma can ... Under the microscope, Ewing sarcoma cells appear small, round and blue.. Ewing sarcoma gets its name from Dr. James Ewing, the ...
Resources from the ARUP Institute for Clinical and Experimental Pathology®. * 28148901 Gardiner JD ... The Ewing sarcoma family of tumors (ESFT) are small round blue cell neoplasms and include classic Ewing sarcoma (ES) of the ... WHO Classification of Tumours of Soft Tissue and Bone - Ewing Sarcoma, Ch 19 de Alava E, Lessnick S, Sorenson. Ewing Sarcoma, ... NCCN - Soft Tissue Sarcomas Version 4.2019 - Ewing/GIST/Sarcoma National Comprehensive Cancer Network. NCCN Clinical Practice ...
An X-ray revealed something no one expected: metastatic Ewing sarcoma. Maddie had a softball-sized mass in her left hip and ... Julia Glade Bender led an early-phase trial of the drug for use in children with Ewing sarcoma. Again the experimental ... Ewing Sarcoma. Get the facts about Ewing Sarcoma and how our research projects are making a difference. ... An X-ray revealed something no one expected: metastatic Ewing sarcoma. Maddie had a softball-sized mass in her left hip and ...
For Ewing sarcoma, the 5-year survival rate has increased over the same time from 59% to 78% for children younger than 15 years ... Therapy was well tolerated, and the 5-year EFS for 35 patients was 80%. This pilot study became the experimental arm of COG- ... Ewing sarcoma of chest wall), and extraosseous Ewing sarcoma (often combined in the term Ewing sarcoma family of tumors) refer ... Characteristics of Children With Extraosseous Ewing Sarcoma and Skeletal Ewing Sarcoma. Characteristic. Extraosseous Ewing ...
Sarcomas are a heterogeneous group of malignant tumors that are derived from mesenchymal tissues, including bone, muscle, and ... Sarcomas with recurrent molecular changes include, among others, Ewing sarcoma, synovial sarcoma, alveolar rhabdomyosarcoma, ... 1.Laboratory of Experimental OncologyIRCCS Istituto Ortopedico RizzoliBolognaItaly. About this chapter. CrossMark ... in patients with sarcoma and Ewings sarcoma: a phase 1 expansion cohort study. Lancet Oncol. 2010;11:129-35.PubMedCrossRef ...
  • Ewing sarcoma tumors disappeared and did not return in more than 70 percent of mice treated with combination therapy that included drugs from a family of experimental agents developed to fight breast cancer, reported St. Jude Children's Research Hospital scientists. (healthcanal.com)
  • minimum of 4 to a maximum of 12 administrations) in combination with irinotecan and temozolomide in subjects with metastatic Ewing's sarcoma Family of Tumors (ESFT) refractory/intolerant or recurrent to 1 prior line of chemotherapy. (clinicaltrials.gov)
  • A combination therapy that included drugs from a family of experimental agents developed to fight breast cancer was administered on mice with Ewing sarcoma tumors. (medindia.net)
  • We now report the outcomes of 20 patients with refractory Ewing's sarcoma (EWS) family tumors after being treated with cixutumumab combined with temsirolimus. (aacrjournals.org)
  • Desmoplastic small-round cell tumor (DSRCT) is a rare and aggressive soft tissue sarcoma, which primarily presents with abdominal masses, and is considered by some to be a part of the EWS family of tumors. (aacrjournals.org)
  • Randomized comparison of every-2-week v. every-3-week chemotherapy in Ewing sarcoma family tumors (ESFT) [abstract]. (wiley.com)
  • Ewing's sarcoma (ES) and peripheral primitive neuroectodermal tumor (pPNET), also called neuroepithelioma, are currently defined as biologically closely related tumors along a gradient of limited neuroglial differentiation. (springer.com)
  • Today, all these neoplasms are summarized as Ewing tumors (ET) or Ewing sarcoma family tumors (ESFT). (springer.com)
  • On the genetic level, Ewing sarcoma family tumors are defined by the consistent presence of a. (springer.com)
  • Bernstein M, Kovar H, Paulussen M et al (2006) Ewing's sarcoma family of tumors: current management. (springer.com)
  • Older terms such as peripheral primitive neuroectodermal tumor, Askin tumor (Ewing sarcoma of chest wall), and extraosseous Ewing sarcoma (often combined in the term Ewing sarcoma family of tumors ) refer to this same tumor. (oncolink.org)
  • The Ewing sarcoma family of tumors (ESFT) are small round blue cell neoplasms and include classic Ewing sarcoma (ES) of the bone, extraskeletal ES, small round-cell tumors of the thoracopulmonary region (Askin tumor), and peripheral-type primitive neuroectodermal tumors (pPNET). (arupconsult.com)
  • Sarcomas are a heterogeneous group of malignant tumors that are derived from mesenchymal tissues, including bone, muscle, and cartilage. (springer.com)
  • Conventionally grouped in either soft-tissue or bone sarcomas according to the site of their origin, these tumors can now be genetically distinguished in two main groups: those carrying tumor-specific recurrent chromosome aberrations and those with complex karyotypes and variable genetic alterations [1, 2]. (springer.com)
  • A new member of the ETS family fused to EWS in Ewing tumors. (springer.com)
  • The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation. (springer.com)
  • R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II sarcoma alliance for research through collaboration study. (springer.com)
  • This region of chromosome 22 encodes the N-terminal transactivation domain of the EWS protein and that region may become joined to one of several other chromosomes which encode various transcription factors, see The expression of a chimeric protein with the EWS transactivation domain fused to the DNA binding region of a transcription factor generates a powerful oncogenic protein causing Ewing sarcoma and other members of the Ewing family of tumors. (wikipedia.org)
  • We analyzed the behavior of public microarray data sets from Ewing sarcoma ("Ewing family tumors," EFT) cell lines and biopsies in GEMusicA after prefiltering DNA microarray data for the probe sets from the stem cell signature. (hindawi.com)
  • Ewing sarcoma (or the "Ewing family of tumors," EFT) is an interesting model for a tumor entity with uncertain cell of origin that might be derived from stem cells. (hindawi.com)
  • We are launching new research collaborations with local and national groups to search for new therapeutics for bone and soft tissue tumors through our Experimental Therapeutics Program. (childrensmercy.org)
  • These tumors are also called Ewing family of tumors (EFTs) and classified into Ewing sarcoma , malignant peripheral primitive neuroectodermal tumors, Askin tumor , and less common tumors (eg, neuroectodermal tumor , ectomesenchymoma, peripheral medulloepithelioma ). (wikidoc.org)
  • To identify novel diagnostic immunohistochemical markers for Ewing sarcoma, we performed comparative expression analyses in 768 tumors representing 21 entities including Ewing-like sarcomas, which confirmed that CIC-DUX4- , BCOR-CCNB3- , EWSR1-NFATc2- , and EWSR1-ETS -translocated sarcomas are distinct entities, and revealed that ATP1A1 , BCL11B , and GLG1 constitute specific markers for Ewing sarcoma. (oncotarget.com)
  • A Multicenter Phase II Clinical Trial of Lurbinectedin (PM01183) in Selected Advanced Solid Tumors (Ewing Sarcoma cohort only). (ior.it)
  • The Department of Experimental Pathology is part of the Lausanne Hospital (CHUV), a leading clinical center for sarcomas and pediatric tumors management, and is affiliated to the Swiss Cancer Center (SCCL). (myscience.ch)
  • Interestingly, the vast majority of the genes mutated in pediatric tumors and sarcomas are involved in chromatin organization, remodeling and cell fate transitions. (myscience.ch)
  • Therefore, the laboratory aim to investigate how single genetic events, driving pediatric tumors and sarcoma development, affect chromatin regulation to rewire cancer cells identities that contribute to cellular transformation. (myscience.ch)
  • The long-term goal of our research is the identification and characterization of pathways implicated in pediatric solid tumors and sarcomas. (myscience.ch)
  • We are particularly interested in identifying epigenetic changes that may underlie tumor cell heterogeneity in different sarcoma types and determining how transformation by different oncogenetic events in distinct cellular contexts determines the epigenetic signature of tumors. (openaccessgovernment.org)
  • In a mouse model, the team showed that CDK12 inhibitors greatly slow down tumor growth and extend the survival rates of mice with Ewing sarcoma tumors. (technologynetworks.com)
  • Ewing's sarcoma (ES) is the second most prevalent malignancy among bone tissue tumors, and there is no adequate prognosis biomarker. (researchsquare.com)
  • EWS shRNA plus TFL also inhibited growth of Ewing's sarcoma tumors in animal models due to inhibition of differentiation inhibitors and angiogenic and invasive factors and also induction of activation of caspase-3 for apoptosis. (scirp.org)
  • Khoury, J.D. (2005) Ewing Sarcoma Family of Tumors. (scirp.org)
  • MPNST (malignant peripheral nerve sheath tumors) are highly aggressive soft tissue sarcomas of Schwann cell (SC) origin, representing a major cause of mortality in neurofibromatosis (NF) patients, which affects 1 in 3500 i. (curesarcoma.org)
  • This research study is a Phase II clinical trial to test the efficacy of Olaparib in adult participants with recurrent/metastatic Ewing's Sarcoma following failure of prior chemotherapy. (clinicaltrials.gov)
  • Primary Objectives Evaluate the objective response rate of olaparib in adult patients with recurrent and/or metastatic Ewing's sarcoma following failure of conventional chemotherapy. (clinicaltrials.gov)
  • Phase II trial to study the effectiveness of combination chemotherapy in treating patients with newly diagnosed metastatic Ewing's sarcoma or primitive neuroectodermal tumor. (clinicaltrials.gov)
  • I. Evaluate the response rate and duration of response of patients with newly diagnosed, metastatic Ewing's sarcoma or primitive neuroectodermal tumor treated with maximally intensified VAdrC (vincristine, doxorubicin, cyclophosphamide) alternating with IE (ifosfamide, etoposide). (clinicaltrials.gov)
  • This trial looked at treosulfan chemotherapy for children, young people and adults with Ewing's sarcoma who already had treatment. (cancerresearchuk.org)
  • Ewing's sarcoma is a type of cancer that usually develops in, or near, the bones. (cancerresearchuk.org)
  • Doctors usually treat Ewing's sarcoma with chemotherapy . (cancerresearchuk.org)
  • Treosulfan is a chemotherapy drug similar to one that was already used to treat people with Ewing's sarcoma. (cancerresearchuk.org)
  • The researchers thought that treosulfan may help people who had already had treatment for Ewing's sarcoma. (cancerresearchuk.org)
  • The trial team found that the dose of treosulfan they used didn't help people with Ewing's sarcoma. (cancerresearchuk.org)
  • The trial team concluded that this dose of treosulfan didn't work for people who had already had treatment for Ewing's sarcoma. (cancerresearchuk.org)
  • Abstract 3453: Selective sensitivity of Ewing's Sarcoma to the PARP inhibitor BMN 673. (aacrjournals.org)
  • Twenty patients [17 with Ewing's sarcoma (EWS), 3 with desmoplastic small-round cell tumor (DSRCT)] were enrolled. (aacrjournals.org)
  • This assumption is supported by preclinical evidence in in vivo Ewing's sarcoma (EWS) and rhabdomyosarcoma models treated with the combination of an mTOR inhibitor and IGF-1R inhibitor, which showed enhanced antitumor activity compared with treatment with each agent alone ( 5, 6 ). (aacrjournals.org)
  • This trial is looking at 4 different types of chemotherapy to treat Ewing's sarcoma that didn't respond to treatment or has come back afterwards. (cancerresearchuk.org)
  • Ewing's sarcoma is a type of cancer that mainly affects teenagers, young adults and children. (cancerresearchuk.org)
  • Doctors can treat Ewing's sarcoma with surgery, chemotherapy or radiotherapy . (cancerresearchuk.org)
  • If Ewing's sarcoma doesn't respond to these treatments, or comes back afterwards, there isn't a standard treatment. (cancerresearchuk.org)
  • In this trial, researchers are comparing 4 different types of chemotherapy that can be used to treat Ewing's sarcoma that hasn't responded to treatment, or has come back afterwards. (cancerresearchuk.org)
  • Askin tumor is the historical designation of Ewing's sarcoma of the chest wall. (springer.com)
  • Kovar H (2005) Context matters: the hen or egg problem in Ewing's sarcoma. (springer.com)
  • A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. (springer.com)
  • A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. (springer.com)
  • EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma. (springer.com)
  • Microsatellites as EWS/FLI response elements in Ewing's sarcoma. (springer.com)
  • A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. (springer.com)
  • Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. (springer.com)
  • In pediatric Ewing's sarcoma a chromosomal translocation generates a fusion of the 5' transactivation domain of EWSR1 (also known as EWS) with the 3' Ets domain of Fli-1. (wikipedia.org)
  • In this experimental plan, David Loeb, MD, PhD describes his research in Ewing's sarcoma stem cells. (sarcomahelp.org)
  • The Liddy Shriver Sarcoma Initiative awards three research grants for the study of Ewing's sarcoma and Osteosarcoma. (sarcomahelp.org)
  • In this work, the functional analysis of gene expression data identified that Rb and Cell Cycle pathways are similarly regulated by EWS/FLI1 (see Figure 1), a chimeric protein related to Ewing's sarcoma oncogenesis, and DAX1. (cnio.es)
  • Array CGH and gene-expression profiling reveals distinct genomic instability patterns associated with DNA repair and cell-cycle checkpoint pathways in Ewing's sarcoma. (cnio.es)
  • ASSET is a EU FP7 collaborative project consisting of 14 partners across Europe with the aim of identifying and analysing network vulnerabilities that can be exploited for the diagnosis and treatment of paediatric tumours, including neuroblastoma, medulloblastoma and Ewing's sarcoma. (warwick.ac.uk)
  • Within the scope of ASSET, effort has been made to unravel the regulation of E2F3 target genes in Ewing's sarcoma. (warwick.ac.uk)
  • EGFR Inhibition Fails to Suppress Vascular Proliferation and Tumor Growth in a Ewing's Sarcoma Model. (tuftsmedicalcenter.org)
  • Drs. Paradis and Gendron have determined that tubedown-1 is important for the growth of experimental Ewing's sarcoma, a type of bone cancer. (mun.ca)
  • MicroRNAs serve a crucial role in the regulation of malignant biological behavior of Ewing's sarcoma (ES). (readbyqxmd.com)
  • MicroRNA-20b promotes cell proliferation via targeting of TGF-β receptor II and upregulates MYC expression in Ewing's sarcoma cells. (readbyqxmd.com)
  • In the present study, we show that miRNA plays an important role in downregulating TGFBR2 expression in Ewing's sarcoma (ES) cells. (readbyqxmd.com)
  • Pediatric Ewing's sarcoma (TC-32), neuroblastoma (IMR32 and KCNR), and glioblastoma (SF188) models were also highly sensitive to PLK1 inhibition. (aacrjournals.org)
  • Patients with non metastatic Ewing's Sarcoma will be randomized into 2 different groups: standard chemotherapy treatment or into the experimental group with dose intensification and shorter length chemotherapy. (ior.it)
  • Ewing's sarcoma is a type of bone cancer found in children and young adults which accounts for 10-15% of all primary malignant bone tumours [ 3 ]. (cancerindex.org)
  • Occasionally it can found entirely restricted to soft tissue (Extraosseous Ewing's Sarcoma). (cancerindex.org)
  • Today it is known that Ewing's sarcoma covers a spectrum ranging from classical Ewing's to those tumours which are positive for neural markers ( Peripheral Neuroectodermal Tumours ). (cancerindex.org)
  • The following year at a meeting of the New York Pathological Society Ewing presented his paper on the malignant bone tumour that was later became known as Ewing's sarcoma. (cancerindex.org)
  • The concept Ewing's sarcoma -- Patients -- Australia -- Biography represents the subject, aboutness, idea or notion of resources found in Randwick City Library . (nsw.gov.au)
  • This is a non-randomised phase II study which aims to explore the efficacy and toxicity of oral treosulfan in patients with advanced, pre-treated Ewing's sarcoma. (isrctn.com)
  • If conventional dose oral treosulfan is demonstrated to be active in patients with advanced Ewing's sarcoma, it is proposed that this study should be followed by a phase III prospective randomised controlled trial comparing oral etoposide (the traditional active palliation agent in solid tumours) with oral treosulfan. (isrctn.com)
  • Non-randomised phase II study of oral treosulfan in advanced pre-treated Ewing's sarcoma. (isrctn.com)
  • We have shown that cancer stem cells (CSC) in Ewing's sarcoma are maintained by transient deregulation of microRNA (miRNA) maturation resulting from epigenetically-mediated repression of TARBP2, which controls maturation of a range of miRNAs. (openaccessgovernment.org)
  • When the pain kept getting worse, she saw another doctor who gave her the grave news: at age sixteen, she had stage IV Ewing's sarcoma. (cancerresearch.org)
  • Most patients with advanced Ewing's sarcoma (EWS) respond poorly to conventional chemotherapy, indicating the need for new treatment approaches. (biomedcentral.com)
  • Metastatic or recurrent Ewing's sarcoma (EWS) does not respond well to standard chemotherapy [ 1 ], suggesting the need for new therapeutic approaches for the treatment of this malignancy. (biomedcentral.com)
  • After three screenings, we identified CCT6A as highly correlated with Ewing's sarcoma prognosis. (researchsquare.com)
  • The expression level of CCT6A is strongly associated with the prognosis of Ewing's sarcoma. (researchsquare.com)
  • High expression of the CCT6A gene may serve as a biomarker for poor prognosis in patients with Ewing's sarcoma. (researchsquare.com)
  • Ewing's sarcoma (ES) is a primary, highly malignant bone tumor originating in the bone marrow, most often occurring in children and adolescents, and is second only to osteosarcoma in its incidence in the adolescent population. (researchsquare.com)
  • Localizing potentially active post-transcriptional regulations in the Ewing's sarcoma gene regulatory network. (inserm.fr)
  • Further, mouse mesenchymal cells transformed with either the EWS-FLI1 or FUS-CHOP rearrangement displayed similar sensitivities to olaparib, whereas the Ewing's sarcoma cell line SK-N-MC had increased olaparib sensitivity. (elifesciences.org)
  • Further, the EWS-FLI1 translocation was reported to be sufficient for increased sensitivity of cells to olaparib, while transient depletion of EWS-FLI1 from Ewing's sarcoma cells resulted in partial rescue of olaparib sensitivity, suggesting the sensitivity of Ewing's sarcoma cells to olaparib might be related to EWS-FLI1 transcriptional activity. (elifesciences.org)
  • Ewing's sarcoma is a pediatric tumor that mainly occurs in soft tissues and bones. (scirp.org)
  • Malignant characteristics of Ewing's sarcoma are correlated with expression of EWS oncogene. (scirp.org)
  • We achieved knockdown of EWS expression using a plasmid vector encoding EWS short hairpin RNA (shRNA) to increase anti-tumor mechanisms of taxifolin (TFL), a new flavonoid, in human Ewing's sarcoma cells in culture and animal models. (scirp.org)
  • Immunofluorescence microscopy and flow cytometric analysis showed high expression of EWS in human Ewing's sarcoma SK-N-MC and RD-ES cell lines. (scirp.org)
  • Collectively, knockdown of EWS expression increased various anti-tumor mechanisms of TFL in human Ewing's sarcoma in cell culture and animal models. (scirp.org)
  • Uren, A. and Toretsky, J.A. (2005) Ewing's Sarcoma Oncoprotein EWS-FLI1: The Perfect Target without a Therapeutic Agent. (scirp.org)
  • Extraosseous Ewing's sarcoma (EES) arising in head and neck is extremely rare. (scirp.org)
  • 3] Angervall, L. and Enzinger, F.M. (1975) Extraskeletal neoplasm resembling Ewing's sarcoma. (scirp.org)
  • 5] Chao, T.K., Chang, Y.L. and Sheen, T.S. (2000) Ex-traskeletal Ewing's sarcoma of the scalp. (scirp.org)
  • 6] Lim, T.C., Tan, W.T. and Lee, Y.S. (1994) Congenital extraskeletal Ewing's sarcoma of the face: A case report. (scirp.org)
  • 7] Iriz, A., Albayrak, L. and Eryilmaz, A. (2007) Extraske-letal primary Ewing's sarcoma of the nasal cavity. (scirp.org)
  • 2005) Primary Ewing's sarcoma of the paranasal sinus with intracranial and intraorbital extension. (scirp.org)
  • 12] Yang, Y.S. and Hong, K.H. (2004) Extraskeletal Ewing's sarcoma of the larynx. (scirp.org)
  • 14] Agir, H., Brasch, H.D. and Tan, S.T. (2007) Extraskeletal Ewing's sarcoma of the submandibular gland. (scirp.org)
  • 15] Zachariades, N., Koumoura, F., Liapi-Avgeri, G. and Bouropoulou, V. (1994) Extraskeletal Ewing's sarcoma of the parotid region: A case report with the detection of the tumour's immunophenotypical characteristics. (scirp.org)
  • 2006) Estab-lishment and characterization of a clonal human ex-traskeletal Ewing's sarcoma cell line, EES1. (scirp.org)
  • Illumina RNA-Seq will be performed on four Ewing's sarcoma cell lines and two control cell lines. (ega-archive.org)
  • By the time Ewing's Sarcoma is diagnosed, primarily in teens and young adults, it has often spread from its primary site to other parts of the body, making it difficult to treat. (medicalxpress.com)
  • Ewing sarcoma is a malignant pediatric bone and soft tissue tumor. (frontiersin.org)
  • The prognosis of high-grade malignant soft tissue sarcoma (STS) arising from a deep compartment is poor because of the high frequency of distant metastasis. (hindawi.com)
  • Ewing sarcoma is a rare malignant pediatric sarcoma of bone and soft tissues, which is more unusual in head and neck region. (readbyqxmd.com)
  • Findings indicate that alterations in miR expression in Ewing Sarcoma are widespread, involve both EWS/Ets oncogenic fusion-dependent and independent mechanisms, and contribute to malignant phenotypes. (frontiersin.org)
  • Virtually nothing is known about tumor cell heterogeneity in sarcomas and we are currently examining a broad range of sarcomas for the existence of relevant subpopulations of malignant cells that play a role in driving tumor growth and progression. (openaccessgovernment.org)
  • Ewing sarcoma is a malignant bone tumour most commonly found in children and young adults. (universiteitleiden.nl)
  • Tulotta C , Stefanescu C, Torraca V, Meijer AM and Snaar Jagalska BE (2016) CXCR4 signaling in the tumor microenvironment orchestrates experimental metastasis formation by controlling myeloid cell motility and response to malignant cells. (universiteitleiden.nl)
  • Synovial sarcoma (SS) is a highly aggressive soft tissue malignancy that affects primarily children and young adults. (openaccessgovernment.org)
  • From adoptive immunotherapy with CD8+ T cells for patients with metastatic synovial sarcoma to revealing a T cell-dependent mechanism of cancer immunoediting in a sarcoma model, our scientists are working toward a future immune to cancer. (cancerresearch.org)
  • Hildebrand, 1890), but it was the work of Ewing which established that the disease was separate from lymphoma or neuroblastoma [ 5 ]. (cancerindex.org)
  • Dr. DuBois is a pediatric oncologist with a clinical focus on the care of children and young adults with solid cancers, including Ewing sarcoma and neuroblastoma. (childrenshospital.org)
  • International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma. (ior.it)
  • In this experimental plan, Nadezhda Koshkina, PhD and Seth Corey, MD describe their research in osteosarcoma metastases. (sarcomahelp.org)
  • Ewing distinguished the tumour from osteosarcoma on the grounds that it was responsive to radiotherapy. (cancerindex.org)
  • Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group. (childrenshospital.org)
  • The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. (springer.com)
  • While osteosarcoma and chondrosarcoma can be considered as the result of a disturbed differentiation programme of MSCs, the origin of Ewing sarcoma is more controverted. (springer.com)
  • We hypothesized that subsets of bone and soft tissue sarcomas could potentially be selectively sensitive to BMN 673, an oral, selective PARP-1/2 inhibitor currently in phase 1 trials (AACR-NCI-EORTC Abstract #B-64, #B-67, 2011). (aacrjournals.org)
  • Methods: We determined the IC 50G of BMN 673 across 50 human soft tissue and bone sarcoma cell lines representing 5 main histologies by exposing the lines to six BMN 673 concentrations over a 6-day incubation and using direct cell counts. (aacrjournals.org)
  • Ewing sarcoma is a type of bone or soft tissue cancer that primarily occurs in children and young adults. (hopkinsmedicine.org)
  • Ewing sarcoma is cancer that occurs primarily in the bone or soft tissue. (hopkinsmedicine.org)
  • Dr. Anderson directed the family to another clinical trial, this one for a drug called Pazopanib, which had been approved by the FDA for adult soft tissue sarcomas. (alexslemonade.org)
  • Eribulin is a new drug to treat soft tissue sarcoma (STS) that exerts antitumor activity by binding to microtubules. (hindawi.com)
  • Scientists at St. Jude Children's Research Hospital have discovered a promising new triple-drug therapy for Ewing sarcoma, a cancer of the bone and soft tissue. (stjude.org)
  • Soft tissue and bone sarcomas are relatively rare cancers but affect a disproportionate number of adolescents and young adults. (childrensmercy.org)
  • The current activities of the Research Units are aimed to a better knowledge of musculoskeletal neoplasm biology, in order to obtain information which may be used to optimise medical treatments in bone and soft-tissue sarcoma patients. (ior.it)
  • Rhabdomyosarcoma is the most common soft-tissue sarcoma of children and adolescents. (aacrjournals.org)
  • No profit, multicenter, international, randomized clinical trial, for the treatment of localized high-risk soft tissue sarcomas of the extremities and trunk wall in adults on the basis of standard neoadjuvant chemotherapy vs histotype-tailored. (ior.it)
  • A Multicenter, Randomized, Open-Label Phase 3 Study to Investigate the Efficacy and Safety of Aldoxorubicin Compared to Investigator's Choice in Subjects with Metastatic, Locally Advanced, or Unresectable Soft Tissue Sarcomas Who Either Relapsed or Were Refractory to Prior Non-Adjuvant Chemotherapy. (ior.it)
  • Safety and activity of trabectedin as first line treatment in advanced soft tissue sarcoma (STS) patients unfit to receive standard chemotherapy: a prospective phase II study with clinical molecular correlates (TR1US). (ior.it)
  • In April 2019, Eli Lilly and Company announced that it is withdrawing Lartruvo (olaratumab) from the market for the treatment of advanced soft tissue sarcoma (STS). (cancerresearch.org)
  • Risks of recurrence and survival after relapse in patients with Ewing tumor [abstract]. (wiley.com)
  • Money raised for sarcoma research will benefit The University of New Mexico Comprehensive Cancer Center. (medindia.net)
  • To exploit our observation that GSTM4 expression is specifically up-regulated in Ewing sarcoma, we tested the effect of a GSTM4-activated anti-cancer agent, O 2 -(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate or JS-K, on tumor growth and survival. (frontiersin.org)
  • This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of childhood Ewing sarcoma. (oncolink.org)
  • Although cytotoxic chemotherapy will remain the mainstay for treating Ewing sarcoma in the near future given its well-trodden track record of antineoplastic activity, high-throughput "-omic" technologies and paired biomarkers are enabling an era of precision medicine that, as has occurred for more common carcinomas such as breast or lung cancer, will increasingly target the unique molecular complexity linked to each patient's respective tumor. (aacrjournals.org)
  • Ewing sarcoma is a very rare cancer in adults. (hopkinsmedicine.org)
  • The Laboratory of Experimental Oncology (Director: Piero Picci, M.D.) is included in the Complex Orthopaedic-Trauma Pathology Department and consists of three Research Units, an epidemiology section, and a Preclinical Section held in collaboration with the Laboratory of Immunology and Biology of Metastasis, Cancer Research Section, Department of Specialised Experimental and Diagnostic Medicine - DIMES, University of Bologna. (ior.it)
  • Ewing had a growing interest in tumours, and was instrumental in establishing the P. Huntington Fund for Cancer Research in 1902. (cancerindex.org)
  • Ewing was a co-founder of the American Association for Cancer Research in 1907. (cancerindex.org)
  • In the same year Ewing co-founded the American Society for the Control of Cancer (now the American Cancer Society ). (cancerindex.org)
  • The friendship between Douglas and Ewing grew, and Ewing became one of the pioneers in using radiotherapy for cancer [ 7 , 8 ]. (cancerindex.org)
  • Nathalie was diagnosed with ASPS, alveolar soft part sarcoma , a cancer so rare that her oncologist, a sarcoma specialist, said Nathalie is her only patient with the disease. (cnbc.com)
  • Last year, BioMarin Pharmaceutical had a public tussle with Andrea Sloan, a woman with ovarian cancer, after it denied her request to access one of its experimental drugs. (cnbc.com)
  • He is Director of Experimental Therapeutics for pediatric oncology and leads a team dedicated to developing new targeted agents for the treatment of childhood cancer. (childrenshospital.org)
  • When combined with an already FDA-approved chemotherapy, a novel agent developed by researchers at Georgetown Lombardi Comprehensive Cancer Center, appears to halt the ability of Ewing sarcoma to grow and progress. (news-medical.net)
  • For these reason, pediatric malignancies and sarcomas clearly represent an unique opportunity to investigate the role of epigenetic deregulation in cancer, in relative isolation from the large number of genetic mutations displayed by their adult counterparts. (myscience.ch)
  • The Experimental Pathology Service at the University of Lausanne cover a range of topics with focus on cancer cells and tumor growths. (openaccessgovernment.org)
  • The Experimental Therapeutics in Pediatric Cancer program makes clinical trials available to your child when traditional cancer therapies have not been successful. (childrensmercy.org)
  • The Experimental Therapeutics Research Team works to provide the best in cancer research expertise while providing the emotional support your family needs. (childrensmercy.org)
  • Screening a class of recently-developed drug compounds -- so-called "CDK inhibitors" capable of blocking CDK7/12/13 proteins -- against hundreds of different human cancer cell lines, researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center have found that CDK12 inhibitors pack a particularly lethal punch to Ewing sarcoma, a rare cancer typically affecting children and young adults. (technologynetworks.com)
  • No one has previously considered CDK12 inhibition as a way to combat Ewing sarcoma," says Kimberly Stegmaier, MD, senior author of the new Cancer Cell paper that describes the findings. (technologynetworks.com)
  • In Ewing sarcoma, the second-most common bone cancer in children and adolescents, an error involving two genes gives rise to an abnormal fusion transcription factor called EWS/FLI. (technologynetworks.com)
  • July is Sarcoma Awareness Month , and as a rarer form of cancer, more awareness and support is urgently needed. (cancerresearch.org)
  • A cancer of the body's connective tissues, including muscle fat, bone, and cartilage, sarcomas account for just one percent of all adult cancer diagnoses in the United States each year. (cancerresearch.org)
  • Sarcoma is more prevalent in children, representing approximately 15% of all childhood cancer cases. (cancerresearch.org)
  • The Cancer Research Institute and Chordoma Foundation have established a research partnership to advance treatment options for chordoma , a rare sarcoma that occurs in the bones of the skull base and spine. (cancerresearch.org)
  • Cancer Research Institute funds immunotherapy for sarcoma research to save more lives. (cancerresearch.org)
  • This integrative project at clinical, biological and biophysical level aims to generate fundamental knowledge of the chemokine network underlying Ewing sarcoma disease with potential application for novel anti-cancer treatments. (universiteitleiden.nl)
  • Bone sarcoma genesis can be explained by a conjunction between a minimum of one oncogenic event and an adequate microenvironment leading to the emergence of cancer, followed by its growth and potential migration to distant organs. (springer.com)
  • Relevant areas of expertise that could be included are (among others) proteomics, structural biology, genomics/epigenomics, medicinal chemistry, experimental therapeutics, and cancer biology. (nih.gov)
  • As the NCI representatives on the PPTC steering committee, Dr. Smith and Beverly Teicher, Ph.D., of NCI's Developmental Therapeutics Program , will work with the PPTC research teams to promote collaborations with pharmaceutical companies and academic laboratories for the testing of promising experimental agents against well-characterized childhood cancer preclinical models, he added. (cancer.gov)
  • The critical component of an experimental vaccine led to an escalating immune response in patients with sarcoma, an indicator of its potential anti-cancer effects. (medicalxpress.com)
  • A team from the Spanish National Cancer Research Centre (CNIO) has optimized a system capable of generating a cellular model of Ewing sarcoma. (medicalxpress.com)
  • The total number of cancer cases diagnosed among people living with the human immunodeficiency virus (HIV) is projected to decline in coming years, due mostly to declines in non-Hodgkin lymphoma and Kaposi sarcoma. (medicalxpress.com)
  • The purpose of this study is to evaluate the safety and preliminary antitumor activity of INCB059872 in participants with Ewing sarcoma who are refractory or relapsed from prior standard therapy and not eligible for further standard systemic therapy. (clinicaltrials.gov)
  • Phase II trial of Linsitinib (anti-IGF-1R/IR) in patients with relapsed and/or refractory Ewing. (ior.it)
  • We found that JS-K robustly decreased Ewing sarcoma cell viability and xenograft tumor growth and improved overall survival of xenograft mice. (frontiersin.org)
  • 20 ] The review reported a pooled incidence of bone marrow metastasis of 4.8% in all patients with newly diagnosed Ewing sarcoma and 17.5% in patients with metastatic disease. (parkviewmc.com)
  • One of our clinical trials for newly diagnosed Ewing sarcoma patients builds on our success from a previous trial. (mskcc.org)
  • We have added these medicines to the others that have been traditionally used to treat newly diagnosed Ewing sarcoma . (mskcc.org)
  • Taken together, these results suggest that IGF1R activation is an escape mechanism to CDK4/6i in Ewing sarcoma and that dual targeting of CDK4/6 and IGF1R provides a candidate synergistic combination for clinical application in this disease. (broadinstitute.org)
  • In advance of anticipated early-phase human clinical trials, we investigated both de novo and acquired mechanism(s) by which Ewing sarcoma cells evade YK-4-279-mediated cell death. (aacrjournals.org)
  • 2 ), and Askin tumor of chest wall ( 3-5 ), have for more than a two decades been considered to represent clinical variants of the same molecularly distinct sarcoma subtype that bears a pathognomonic EWS-ETS oncogenic fusion protein ( 6 ). (aacrjournals.org)
  • Although polychemotherapy has led to marked improvement in 5-year survival for patients diagnosed with localized Ewing sarcoma-approaching 80% with current generation clinical trials-those with metastatic disease or rapid tumor recurrence fare poorly and often quickly succumb to their disease ( 8-11 ). (aacrjournals.org)
  • In a clinical trial, doctors evaluate a new therapy or a therapy combination to find out whether it is more effective than current Ewing sarcoma treatments . (mskcc.org)
  • We also participate in many nationwide clinical trials as a founding member of the Children's Oncology Group, as the coordinating center and co-founder of the Pediatric Oncology Experimental Therapeutics Investigators' Consortium, and through other trial networks across the United States. (mskcc.org)
  • Learn more about MSK's current clinical trials for Ewing sarcoma. (mskcc.org)
  • Molecular characterization of musculoskeletal sarcomas is aimed at the identification of genetic and/or protein biomarkers correlated to the state of the disease, with a relevant clinical impact for diagnostic, prognostic and therapeutic implications. (ior.it)
  • They're still experimental, and Nathalie doesn't qualify for the clinical trials: they start at age 18. (cnbc.com)
  • The U.S. has a system meant to help: it's called compassionate use and it's a way for terminally ill or otherwise optionless patients to access experimental drugs outside of clinical trials. (cnbc.com)
  • They aim to facilitate patients' access to experimental medicines by eliminating the need to get the FDA's go-ahead, provided the compounds have been through the initial round of safety testing in phase 1 clinical trials. (cnbc.com)
  • Comparison of Epidemiology, Clinical Features, and Outcomes of Patients with Reported Ewing Sarcoma and PNET over 40 Years Justifies Current WHO Classification and Treatment Approaches. (childrenshospital.org)
  • Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. (epa.gov)
  • Stegmaier's project team, led by postdoctoral fellow Amanda Balboni Iniguez, PhD, hypothesized that inhibiting CDK12 in Ewing sarcoma might have a double-whammy clinical benefit: slowing down the growth of Ewing cells and also making them lethally sensitive to PARP inhibitors. (technologynetworks.com)
  • Check for an updated list of approved treatments and sarcoma clinical trial targets. (cancerresearch.org)
  • Many advanced, metastatic sarcomas are resistant to conventional approaches, and clinical trials provide access to cutting-edge medicine. (cancerresearch.org)
  • Immunotherapies have shown effectiveness in clinical trials and could become approved for sarcoma patients in the near future. (cancerresearch.org)
  • Clinical and Experimental Hypertension. (elsevier.com)
  • The present review aims to give an overview on the main characteristics of bone sarcomas with a specific focus on the most recent clinical developments. (springer.com)
  • New treatment protocol for Ewing sarcoma patients in UK following successful completion of clinical trial. (bcrt.org.uk)
  • Results from the Euro Ewing 2012 clinical trial have redefined UK treatment for Ewing sarcoma after finding a more effective standard of chemotherapy. (bcrt.org.uk)
  • The PPTP and other research teams have also shown that preclinical testing, when combined with knowledge about the relative drug exposures that can be tolerated by mice and humans, "provides powerful insight into the likely clinical utility of experimental agents," Dr. Smith said. (cancer.gov)
  • Ewing sarcoma is a transcription factor-mediated pediatric bone tumor caused by a chromosomal translocation of the EWSR1 gene and one of several genes in the ETS family of transcription factors, typically FLI1 or ERG. (aacrjournals.org)
  • However, researchers have discovered chromosomal changes in a cell's DNA that can lead to the formation of Ewing sarcoma. (hopkinsmedicine.org)
  • Prognostic impact of chromosomal aberrations in Ewing tumours. (springer.com)
  • Genetically, Ewing sarcoma is defined by balanced chromosomal EWS/ETS translocations, which give rise to oncogenic chimeric proteins (EWS-ETS). (uzh.ch)
  • Understanding the epigenetic mechanisms driving the development of human sarcomas expressing specific chromosomal translocations. (myscience.ch)
  • Although the genetic abnormality causing Ewing sarcoma as consistent reciprocal chromosomal translocation is known, patients with metastases have very poor prognosis. (universiteitleiden.nl)
  • About 225 children and adolescents are diagnosed with Ewing sarcoma in the U.S. each year. (hopkinsmedicine.org)
  • PNET was first discovered by James Ewing, an American pathologist , in 1921. (wikidoc.org)
  • Pharmacological inhibition of GSTM4 activity using a pan GST inhibitor, 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol (NBDHEX), significantly limited cellular proliferation and oncogenic transformation of Ewing sarcoma cells. (frontiersin.org)
  • Vascular Endothelial Growth Factor Receptor-2 Inhibition in Experimental Murine Colitis. (tuftsmedicalcenter.org)
  • Infographic showing how PARP and CDK12 inhibition lead to deficient DNA damage repair and cell death in Ewing sarcoma cells. (technologynetworks.com)
  • What's more, her team has discovered that CDK12 inhibition can be combined with another drug, called a PARP inhibitor, to double down on Ewing sarcoma cells. (technologynetworks.com)
  • The revelation that CDK12 inhibition can kill Ewing sarcoma cells brings a surge of hope to the field of pediatric oncology, which has long been challenged to find new drugs against childhood cancers. (technologynetworks.com)
  • After their wide-ranging drug screen revealed a potential link between CDK12 inhibition and Ewing sarcoma, the team sought to understand why. (technologynetworks.com)
  • Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma. (uzh.ch)
  • Our preclinical results suggest Ewing sarcoma is particularly sensitive to this combination therapy, a possible indication that the tumor's DNA repair defect provides us with a much needed advantage to knock out tumor cells," Shelat said. (healthcanal.com)
  • A major effort consists of characterizing the epigenetic changes that distinguish CSCs from bulk tumor cells in Ewing sarcoma and determining how such changes confer not only stem cell properties onto Ewing s sarcoma cells but also the ability to invade adjacent tissues, metastasize and resist conventional therapy. (openaccessgovernment.org)
  • Carley decided to try an experimental immunotherapy called FANG (now called Vigil™), which uses her own tumor cells as a vaccine. (cancerresearch.org)
  • Although first described in 1866 and 1890 by Lücke and Hildebrand, respectively, the disease carries the name of the American pathologist James Ewing who, in 1921, was the first to recognize the tumor as a separate entity, which he defined as diffuse endothelioma of the bone. (springer.com)
  • Ewing sarcoma gets its name from Dr. James Ewing, the doctor who first described the tumor in the 1920s. (hopkinsmedicine.org)
  • Primitive neuroectodermal tumor was first discovered by James Ewing, an American pathologist , in 1921. (wikidoc.org)
  • James Ewing first described the tumour that was to be named after him in the 1920's [ 1 , 2 ]. (cancerindex.org)
  • Patients with extraosseous Ewing sarcoma were more likely to be older, female, nonwhite, and have axial primary sites, and were less likely to have pelvic primary sites than were patients with skeletal Ewing sarcoma. (oncolink.org)
  • An X-ray revealed something no one expected: metastatic Ewing sarcoma. (alexslemonade.org)
  • During the past 20 years there has been no significant improvement in the cure rate for Ewing sarcoma, and survival is just 15 to 20 percent for patients whose disease has spread or comes back after treatment," said co-corresponding author Michael Dyer , Ph.D., a Howard Hughes Medical Institute (HHMI) investigator and a member of the St. Jude Department of Developmental Neurobiology. (healthcanal.com)
  • Ewing Sarcoma (ES) shows several deregulated autocrine loops mediating cell survival and proliferation. (aacrjournals.org)
  • Ewing Sarcoma (ES) is a neoplasm affecting children and young adults, in which 5-year survival rates remain around 70% ( 1 , 2 ). (aacrjournals.org)
  • For Ewing sarcoma, the 5-year survival rate has increased over the same time from 59% to 78% for children younger than 15 years and from 20% to 60% for adolescents aged 15 to 19 years. (oncolink.org)
  • Over the course of the last 20 years survival rates for patients with Ewing sarcoma have increased as a consequence of therapy intensification, improvement of surgical techniques and radiotherapy. (biomedcentral.com)
  • Moreover, elevated IL6 levels in peripheral blood of patients with bone sarcomas correlate with higher tumor extension and decreased overall survival [ 10 ]. (biomedcentral.com)
  • For the first time in over 10 years of Ewing sarcoma trials, EE2012 showed the survival of patients was better in the experimental arm B VDC/IE. (bcrt.org.uk)
  • In this study, we performed a bioinformatics analysis of 32 Ewing sarcoma specimens from the GSE17618 dataset for differences in gene expression and overall survival, event-free survival, and gene expression in different subgroups. (researchsquare.com)
  • On the other hand, Cox regression analysis showed that CCT6A expression, event-free survival (EFS), and age were strongly associated with the prognosis of Ewing sarcoma, identified as independent poor prognostic biomarkers. (researchsquare.com)
  • Studies using immunohistochemical markers, cytogenetics, molecular genetics, and tissue culture indicate that Ewing sarcoma is derived from a primordial bone marrow-derived mesenchymal stem cell. (oncolink.org)
  • The cyclin-dependent kinase (CDK)4/6 pathway recently emerged as a dependency in Ewing sarcoma, an aggressive pediatric malignancy. (broadinstitute.org)
  • Heretofore, simply referred to as Ewing sarcoma, this sarcoma subtype is a highly aggressive malignancy of adolescents and young adults ( 7 ) that is rapidly fatal without effective multimodality treatment that includes surgery and/or radiation and extensive use of systemic chemotherapy. (aacrjournals.org)
  • Ewing sarcoma is the second most common pediatric bone malignancy. (eurekalert.org)
  • Ewing sarcoma (ES) is a high-grade malignancy in which approximately 75% of cases are localized at diagnosis, and 25% are initially metastatic [ 1 , 2 ]. (omicsonline.org)
  • Rhabdomyosarcoma, consisting of alveolar (aRMS) and embryonal (eRMS) subtypes, is the most common type of sarcoma in children. (aacrjournals.org)
  • Histologically or cytologically confirmed diagnosis of Ewing sarcoma and have progressed on or after standard therapies. (clinicaltrials.gov)
  • The median time from first symptom to diagnosis of Ewing sarcoma is often long, with a median interval reported from 2 to 5 months. (oncolink.org)
  • Approximately 25% of patients with Ewing sarcoma have metastatic disease at the time of diagnosis. (oncolink.org)
  • 18 ] Approximately 25% of patients with Ewing sarcoma have metastatic disease at the time of diagnosis. (parkviewmc.com)
  • Despite the life-threatening diagnosis of advanced Ewing sarcoma, Maruska and Jeff Goodwin, Leicester, United Kingdom, were determined to find answers for their 8-year-old son, Alex. (childrensmercy.org)
  • Ewing sarcoma cell lines with inhibited Ewing sarcoma breakpoint region 1-Friend leukemia virus integration 1 (EWSR1-FLI1) oncogene retained the similarity to ESC and EC. (hindawi.com)
  • In most cases, the TET family member EWSR1 (Ewing sarcoma breakpoint region 1) is fused to the ETS family member FLI1 (Friend leukemia virus integration 1). (hindawi.com)
  • Collectively, we show that ATP1A1 , BCL11B , and GLG1 are EWSR1-FLI1 targets, of which BCL11B and GLG1 offer a fast, simple, and cost-efficient way to diagnose Ewing sarcoma by immunohistochemistry. (oncotarget.com)
  • Embree, L.J., Azuma, M. and Hickstein, D.D. (2009) Ewing Sarcoma Fusion Protein EWSR1/FLI1 Interacts with EWSR1 Leading to Mitotic Defects in Zebrafish Embryos and Human Cell Lines. (scirp.org)
  • GSTM4 is required for oncogenic transformation and mediates resistance to chemotherapeutic drugs in Ewing sarcoma cells. (frontiersin.org)
  • Here, we performed RNA-sequencing analyses of Ewing sarcoma cells and combined our results with publicly available datasets to demonstrate that GSTM4 is a major GST specifically expressed in Ewing sarcoma. (frontiersin.org)
  • Ewing sarcoma cells can also metastasize (spread) to other areas of the body, including the bone marrow, lungs, kidneys, heart, adrenal glands and other soft tissues. (hopkinsmedicine.org)
  • Under the microscope, Ewing sarcoma cells appear small, round and blue. (hopkinsmedicine.org)
  • CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis. (springer.com)
  • We recreated a total mistletoe effect (viscumTT) by combining an aqueous extract (viscum) and a triterpene extract (TT) solubilised with cyclodextrins and analysed the effects of viscumTT and the single extracts on TC-71 Ewing sarcoma cells in vitro by transcriptomic and proteomic profiling. (biomedcentral.com)
  • Since the combinatory extract viscumTT exerts highly effective pro-apoptotic effects on Ewing sarcoma cells in vitro, this phytopolychemotherapy could be a promising adjuvant therapeutic option for paediatric patients with Ewing sarcoma. (biomedcentral.com)
  • Now, in mice, we've shown that Ewing sarcoma cells die if CDK12 is knocked out genetically or chemically inhibited," Stegmaier says. (technologynetworks.com)
  • We have discovered that CDK12 inhibitors repress genes important to the regulation of DNA damage in Ewing sarcoma cells, and therefore these EWS/FLI positive Ewing sarcoma cells are very sensitive to PARP inhibitors. (technologynetworks.com)
  • The interaction of Ewing sarcoma cells with the tumor microenvironment is essential for tumour growth, angiogenesis and metastasis. (universiteitleiden.nl)
  • In the current multidisciplinary project we want to further develop, explore, and experimentally test concepts and molecular components of chemokine gradient sensing that leads to migration of immune, endothelial and tumour cells during tumor progression and angiogenesis in Ewing sarcoma. (universiteitleiden.nl)
  • In the top row, green represents locations of DNA damage incurred by Ewing sarcoma cells. (childrenshospital.org)
  • The treatment paired two chemotherapy drugs currently used to treat Ewing sarcoma (EWS) with experimental drugs called poly-ADP ribose polymerase (PARP) inhibitors that interfere with DNA repair. (healthcanal.com)
  • Given the heightened efficacy of this class with targeted drug combinations in other cancers, as well as the propensity of resistance to emerge with single agents, we aimed to identify genes mediating resistance to CDK4/6 inhibitors (CDK4/6i) and biologically relevant combinations for use with CDK4/6i in Ewing. (broadinstitute.org)
  • Therapies targeting the insulin-like growth factor 1 receptor (IGFIR), alone or in combination with inhibitors of mammalian target of rapamycin (mTOR), provide just one example of selective biologically targeted therapies capable of inducing striking tumor regression among a subset of Ewing sarcoma patients ( 12, 13 ). (aacrjournals.org)
  • In this experimental plan, Jeffrey Toretsky, MD describes his research towards identification of small molecule protein-protein interaction inhibitors. (sarcomahelp.org)
  • The therapy consisted of two drugs currently used to treat Ewing sarcoma, plus experimental drugs called PARP inhibitors that interfere with a cellular process called DNA repair. (stjude.org)
  • Fluorescent staining shows how PARP and CDK12 inhibitors combine to deal a lethal blow to Ewing sarcoma. (childrenshospital.org)
  • Together, PARP and CDK12 inhibitors lead to Ewing sarcoma cell death. (childrenshospital.org)
  • The prognosis of patients with Ewing sarcoma (ES) has improved over the course of the last decades. (biomedcentral.com)
  • Although many cancers are showing remarkable responses to targeted therapies, pediatric sarcomas, including Ewing sarcoma, remain recalcitrant. (aacrjournals.org)
  • Unfortunately, effective treatment for relapsed sarcoma has remained largely elusive, despite the fact that sarcomas are among the most common cancers of childhood and early adolescence ( 7, 8 ). (aacrjournals.org)
  • It makes up less than 1 percent of all sarcomas, which themselves make up just 1 percent of all cancers. (cnbc.com)
  • Experimental Therapeutics is the science of taking those treatments and trialing them with different cancers to test their effectiveness. (childrensmercy.org)
  • In Ewing sarcoma and other cancers involving transcription factor fusion 'onco-proteins' like EWS/FLI, these mutated transcription factors drive abnormal cell behavior and tumor growth," Stegmaier explains. (technologynetworks.com)
  • Sarcomas-cancers of the connective tissues like muscles, joints, fat and bone-come in dozens of subtypes. (medicalxpress.com)
  • The trial, which began recruiting patients in 2014 and completed in 2019, aimed to establish a single standard of chemotherapy for Ewing sarcoma at an international level. (bcrt.org.uk)
  • What is experimental therapeutics? (childrensmercy.org)
  • As part of the Experimental Therapeutics Team, the IDS Pharmacy staff provides protocol and sponsor directed security, accountability, education, and dispensing of all Investigational as well as ancillary medications. (childrensmercy.org)
  • The relative paucity of Ewing sarcoma in people of African or Asian descent may be explained, in part, by a specific polymorphism in the EGR2 gene. (oncolink.org)
  • COLUMBUS, Ohio - In a study published in PLOS ONE , researchers describe two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma. (eurekalert.org)
  • Treatment with the extracts strongly impacted Ewing sarcoma cell gene and protein expression. (biomedcentral.com)
  • Oncogene, 2008) have revealed a new function for DAX1 gene as a cell-cycle progression regulator in Ewing's sarcomas. (cnio.es)
  • Some investigational drugs did show substantial activity in several models, however, including the MEK inhibitor selumetinib in gliomas with mutations in the BRAF gene and the PARP inhibitor talazoparib (in combination with low-dose temozolomide) for Ewing sarcoma. (cancer.gov)
  • Ewing first described the tumour as an "endothelioma of bone" believing that it arose from the blood vessels of bone tissue. (cancerindex.org)
  • Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. (springer.com)
  • Bone sarcomas belong to a mesenchymal tumour family originating from bone and composed by highly heterogeneous subtypes. (springer.com)
  • St. Jude researchers conducted a series of mouse experiments designed to mirror the human phase I, II and III studies that gauge the safety and effectiveness of experimental treatment in humans. (healthcanal.com)
  • ALSF-funded researcher, Dr. Julia Glade Bender led an early-phase trial of the drug for use in children with Ewing sarcoma. (alexslemonade.org)
  • By advancing an oral formulation of YK-4-279 and identifying prominent mechanisms of resistance, this preclinical research takes us one step closer to a shared goal of curing adolescents and young adults afflicted by Ewing sarcoma. (aacrjournals.org)
  • To broaden the therapeutic landscape, we explored the in vitro response of Ewing sarcoma cell lines against a large collection of investigational and approved drugs to identify candidate combinations. (aacrjournals.org)
  • Conclusions: A large panel of Ewings sarcoma cell lines demonstrate selective in vitro and in vivo sensitivity to BMN 673, this response may be augmented by the addition of cytotoxic chemotherapy. (aacrjournals.org)
  • We have previously shown that mistletoe lectins and triterpene acids are effective against Ewing sarcoma in vitro, ex vivo and in vivo. (biomedcentral.com)
  • RNA interference of FGFR1 expression in Ewing sarcoma lines blocked proliferation and completely suppressed xenograft tumor growth. (uzh.ch)
  • In the years the laboratory has specialized in translational research of musculoskeletal sarcomas and in optimizing multidisciplinary treatments. (ior.it)
  • With no systemic treatments approved for this sarcoma and new results in immunotherapy research published weekly, it's a prime opportunity to test immunotherapies in chordoma patients. (cancerresearch.org)
  • Several senior researchers, PhD students, and student fellows presently work at the Laboratory of Experimental Oncology. (ior.it)
  • CHOA Experimental Therapy Pediatric Oncology Research. (alexslemonade.org)
  • A systematic review of Ewing sarcoma studies was performed to assess the incidence of bone marrow metastasis and the role of fluorine F 18-fludeoxyglucose (18F-FDG) PET imaging to detect bone marrow metastasis. (parkviewmc.com)
  • Specific molecular alterations have been associated with specific histological subtypes of sarcomas, leading to a new classification of many sarcomas. (springer.com)
  • Notwithstanding advances over the last decade in the comprehension of the molecular biology of Ewing sarcoma (ES), we still lack an understanding of critical issues, especially those regarding its genesis. (omicsonline.org)
  • Opportunities for improving the therapeutic ratio for patients with sarcoma. (springer.com)
  • A combination CDK4/6 and IGF1R inhibitor strategy for Ewing sarcoma. (broadinstitute.org)
  • FGFR1 tyrosine kinase inhibitor (TKI) therapy in a patient with Ewing sarcoma relapse significantly reduced 18-FDG-PET activity. (uzh.ch)
  • Multiplexed quantitation is certainly a major benefit of this approach, because it permits the simultaneous evaluation of INCB8761 tyrosianse inhibitor INCB8761 tyrosianse inhibitor examples, and a loss of total MS evaluation moments and of experimental/specialized variability. (columbiagypsy.net)
  • If your sarcoma responds well, your doctor may decide to give you more cycles of treatment. (cancerresearchuk.org)
  • They want to find out if PET-CT scans are better than other types of scan at measuring how widespread the sarcoma is before and after treatment. (cancerresearchuk.org)
  • Ewing sarcoma treatment options include multidrug chemotherapy, surgery, and radiation therapy. (oncolink.org)
  • Get detailed treatment information for Ewing sarcoma in this summary for clinicians. (oncolink.org)
  • Again the experimental treatment seemed to work, but then Maddie relapsed-this time in her brain. (alexslemonade.org)
  • Pre-treatment with Anti-VEGF Therapy May Exacerbate Inflammation in Experimental Acute Colitis. (tuftsmedicalcenter.org)
  • These and future studies of miR biology stand to expand our understanding of Ewing sarcoma pathogenesis, and may identify new biomarkers and treatment options. (frontiersin.org)
  • No profit, multicenter, prospective study for treatment of Ewing metastatic sarcoma (lung metastasis/single bone metastases). (ior.it)
  • VDC/IE will become the new standard of chemotherapy treatment for Ewing sarcoma patients in the UK moving forward. (bcrt.org.uk)
  • Maksimenko, A. and Malvy, C. (2005) Oncogene-Targeted Antisense Oligonucleotides for the Treatment of Ewing Sarcoma. (scirp.org)