Evodia
Limonins
Alkaloids
Plant Extracts
Drugs, Chinese Herbal
Calcitonin Gene-Related Peptide
Effects of Wu-chu-yu-tang and its component herbs on drug-metabolizing enzymes. (1/24)
The compound herbal medicine Wu-chu-yu-tang is used for the treatment of migraine and vomiting accompanying a cold. To assess the interactions of herb and drug metabolism, effects of Wu-chu-yu-tang on hepatic and renal cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT) and glutathione S-transferase (GST) were studied in C57BL/6J mice. Treatment of mice with 5 g/kg per day Wu-chu-yu-tang for 3 days caused 2.5-fold and 2.9-fold increases of liver microsomal 7-ethoxyresorufin O-deethylation (EROD) and 7-methoxyresorufin O-demethylation activities, respectively. However, CYP activities toward 7-ethoxycoumarin, benzphetamine, N-nitrosodimethylamine, erythromycin and nifedipine, and conjugation activities of UGT and GST were not affected. In kidney, Wu-chu-yu-tang-treatment had no effects on Cyp, UGT and GST activities. Among the four component herbs of Wu-chu-yu-tang, only Evodiae Fructus (Wu-chu-yu) extract increased EROD activity and CYP1a2 protein level. In E. Fructus, rutaecarpine, evodiamine and dehydroevodiamine are the main active alkaloids. At the doses corresponding to their contents in Wu-chu-yu-tang, rutaecarpine-treatment increased hepatic EROD activity, whereas evodiamine and dehydroevodiamine had no effects. These results demonstrated that ingestion of Wu-chu-yu-tang elevated mouse hepatic Cyp1a2 activity and protein level. E. Fructus and rutaecarpine contributed at least in part to the CYP1a2 induction by Wu-chu-yu-tang. Patients should be cautioned about the drug interaction of Wu-chu-yu-tang and CYP1A2 substrates. (+info)In vivo action of novel alkyl methyl quinolone alkaloids against Helicobacter pylori. (2/24)
Previously purified and isolated compounds of novel alkyl methyl quinolone alkaloids (AM quinolones) from Gosyuyu (Wu-Chu-Yu), a Chinese herbal medicine, have a strong and highly selective antibacterial activity against Helicobacter pylori in vitro. To clarify the antibacterial mechanism(s) of AM quinolones, we examined the effects of AM quinolones on respiration of H. pylori in vitro. One week after treatment with AM quinolones alone (2, 10 or 20 mg/kg/day, orally) or combinations of AM quinolones and omeprazole (30 mg/kg/day) for H. pylori (1 x 10(8) cfu)-infected Mongolian gerbils, we checked viable H. pylori and myeloperoxidase (MPO) activity in the gastric tissues. AM quinolones decreased the number of H. pylori and inhibited H. pylori respiration in a dose-dependent manner. AM quinolones decreased the number of viable H. pylori (AM quinolones alone: 46.0 +/- 22.6 x 10(4), 17.3 +/- 4.9 x 10(4) and 8.1 +/- 6.6 x 10(4) cfu/stomach, respectively; and combinations of AM quinolones and omeprazole: 8.0 +/- 5.6 x 10(4), 4.2 +/- 2.5 x 10(4) and 5.5 +/- 2.7 x 10(4) cfu/stomach) compared with the vehicle-treated group (control: 359.9 +/- 180.3 x 10(4) cfu/stomach). AM quinolones significantly decreased MPO activity of H. pylori-inoculated gastric tissues. These findings suggest that AM quinolones have a potent antibacterial effect against H. pylori through respiratory inhibition, and reduced bacterial growth in vivo. AM quinolones might be novel therapeutic agents for H. pylori eradication. (+info)Anti-invasive and metastatic activities of evodiamine. (3/24)
We have recently reported that evodiamine can suppress in vitro invasion and lung metastasis by colon 26-L5 carcinoma cells. To extend our study, we examine here the anti-invasive and metastatic effects of evodiamine on Lewis lung carcinoma (LLC) and B16-F10 melanoma in addition to colon 26-L5 carcinoma. Critical structures of evodiamine for the activities were also evaluated by comparison with compounds possessing structures similar to that of evodiamine. Evodiamine concentration-dependently inhibited the invasion of B16-F10, LLC and colon 26-L5 cells with IC(50) values of 2.4 micro M, 4.8 micro M and 3.7 micro M, respectively. Pre-treatment of colon 26-L5 cells with evodiamine before inoculation into mice caused significant suppression of the liver metastasis as well as the lung metastasis. Lung metastasis by LLC is also inhibited significantly by pre-exposure to evodiamine. When the anti-migratory activity of evodiamine was compared with that of evodiamine-like compounds, rutaecarpine lacking a methyl group at N-14 and a hydrogen at C-13 b exhibited much less effect than evodiamine. In addition, reserpine, having beta-configurated hydrogen at C-13 b, inhibited tumor cell migration more potently than yohimbine, having alpha-configurated hydrogen at the same position. These results suggest that evodiamine may be useful as a leading compound for agents in tumor metastasis therapy. Also, the presence of a methyl group at N-14 and the configuration of hydrogen at C-13 b may be responsible for the inhibitory activities of evodiamine. (+info)1-methyl-2-undecyl-4(1H)-quinolone as an irreversible and selective inhibitor of type B monoamine oxidase. (4/24)
The inhibitory compound of monoamine oxidase (MAO) activity was isolated from the CH(2)Cl(2) fraction of the fructus of Evodia rutaecarpa and identified as 1-methyl-2-undecyl-4(1H)-quinolone (1). Compound 1 showed a selective inhibition of type B MAO (MAO-B) activity with the IC(50) value of 15.3 microM using a substrate kynuramine, but did not inhibit type A MAO (MAO-A) activity. The kinetic analysis using Lineweaver-Burk plots indicated that compound 1 competitively inhibited MAO-B activity with the K(i) value of 9.91 microM. The inhibition of MAO-B by compound 1 was found to be irreversible by dialysis of the incubation mixture. These results suggest that compound 1 is a potent irreversible inhibitor of MAO-B, and may regulate catecholamine content in the neurons. (+info)Intracellular regulation of evodiamine-induced A375-S2 cell death. (5/24)
We have reported that in A375-S2 cells, evodiamine isolated from Evodia rutaecarpa induces cell death of human melanoma, A375-S2, through two distinct pathways: apoptosis and necrosis. In the present study, we further demonstrate two different mechanisms by which evodiamine induces apoptosis and necrosis. Although caspase-1 and -10 inhibitors failed to block cell death, pan-caspase inhibitor and caspase-3, -8, and -9 inhibitors had marked inhibitory effects on apoptosis induced by 15 microM evodiamine. Furthermore, evodiamine-induced activation of caspase-3 resulted in the down-regulation of anti-apoptotic Bcl-2 expression and up-regulation of proapoptotic Bax expression. After 24 h incubation with evodiamine, no caspase inhibitor had any influence on cell death, but p38 mitogen-activated protein kinase (MAPK) inhibitor (SB203580) attenuated cell death; in contrast, extracellular signal-regulated protein kinase (ERK) MAPK inhibitor (PD98059) augmented cell death, as was further confirmed by cotreatment with SB203580 or PD98059 and pan-caspase inhibitor. Moreover, evodiamine increased the phosphorylation of p38 and decreased the expression and phosphorylation of ERK in caspase-independent necrosis. Consequently, evodiamine induced the caspase- and Bax-mediated apoptosis at an early stage, but, initiated MAPKs-dependent necrosis at a later stage. (+info)Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis. (6/24)
AIM: To study the different death pathways in human cervical cancer HeLa and melanoma A375-S2 cells initiated by evodiamine. METHODS: Viability of evodiamine-induced HeLa and A375-S2 cells was measured by MTT assay. Apoptotic cells with condensed or fragmented nuclei were visualized by Hoechst 33258 staining. Nucleosomal DNA fragmentation was assayed by agarose gel electrophoresis. Proportion of cell death through apoptotic and necrotic pathways was determined by LDH activity-based cytotoxicity assays. Cell cycle distribution was observed by flow cytometry. RESULTS: Evodiamine induced HeLa and A375-S2 cell death dose- and time-dependently. Caspase-3 and -8 were activated in apoptosis induced by evodiamine 15 micromol/L. However, over 24-h incubation of A375-S2 cells, evodiamine 15 micromol/L initiated necrosis related to p38 and ERK (extracellular signal-regulated kinases) activities. Evodiamine-induced HeLa cell death was preceded by an accumulation of cells at the G2/M phase of the cell cycle, but there was no significant effect of evodiamine on A375-S2 cell cycle. CONCLUSION: Evodiamine induces caspase-3,8-dependent apoptosis in HeLa cells which is related to G2/M arrest of the cell cycle. On the other hand, in A375-S2 cells, evodiamine initiates caspase-3,8-mediated apoptosis at early stages and the induction of MAPK-mediated necrosis at later stages of cell culture. (+info)Inhibition by evodiamine of hepatocyte growth factor-induced invasion and migration of tumor cells. (7/24)
Tumor cell motility plays a crucial role in the establishment of tumor metastasis and is affected by a variety of host-derived factors during the event. Hepatocyte growth factor (HGF) is one of these factors and stimulates tumor cell migration remarkably. We previously reported that evodiamine has a marked inhibitory activity on tumor cell invasion and migration in vitro. In this study, the effects of evodiamine on HGF-induced invasion and migration of tumor cell lines, colon 26-L5 carcinoma, B16-F10 melanoma and Lewis lung carcinoma (LLC) were examined. HGF promoted invasive activity of tumor cell lines with maximal induction of 1.8 times at 30 ng/ml for colon 26-L5 and LLC cells, and 2.0 times at 10 ng/ml for B16-F10 cells. Evodiamine inhibited the HGF-stimulated tumor cell invasion and migration in a concentration-dependent manner, and achieved complete suppression at 30 microM in all of the cell lines tested. When tumor cells were seeded on fibronectin-coated plates with evodiamine, their spreading on the plate was obviously inhibited, while their adhesiveness to fibronectin was unaffected. Evodiamine showed a marginal effect on tumor cell growth in a 24-h incubation, although it exhibited a marked inhibition in an over 48-h incubation. These results suggest that evodiamine suppressed HGF-stimulated invasion and migration of tumor cells partly through inhibition of cell spreading. (+info)Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa. (8/24)
Nine quinolone alkaloids (1-9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-kappa B-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC(50) values between 0.91 microM and 15.91 microM. Of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-kappa B activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity. (+info)Evodia is a plant genus that belongs to the family Rutaceae. It is also known as Evodia rutaecarpa, and its fruit is used in traditional Chinese medicine for treating various conditions such as nausea, vomiting, abdominal pain, and diarrhea. The active constituent of Evodia is evodiamine, which has been studied for its potential medicinal properties, including anti-inflammatory, analgesic, and anti-cancer effects. However, more research is needed to confirm these effects and establish the safety and efficacy of Evodia as a medical treatment.
Limonin is not a medical term, but a chemical compound found in various plants, including citrus fruits. It is a type of limonoid, which is a class of naturally occurring compounds that are known for their bitter taste and potential health benefits. Specifically, limonin is found in the seeds and membranes of citrus fruits such as oranges, lemons, and grapefruits.
Limonin has been studied for its potential medicinal properties, including its antioxidant, anti-inflammatory, and chemopreventive effects. However, more research is needed to fully understand its mechanisms of action and potential health benefits in humans. It's important to note that while limonin may have potential health benefits, it should not be used as a substitute for medical treatment or advice from a healthcare professional.
Indole alkaloids are a type of naturally occurring organic compound that contain an indole structural unit, which is a heterocyclic aromatic ring system consisting of a benzene ring fused to a pyrrole ring. These compounds are produced by various plants and animals as secondary metabolites, and they have diverse biological activities. Some indole alkaloids have important pharmacological properties and are used in medicine as drugs or lead compounds for drug discovery. Examples of medically relevant indole alkaloids include reserpine, which is used to treat hypertension, and vinblastine and vincristine, which are used to treat various types of cancer.
Alkaloids are a type of naturally occurring organic compounds that contain mostly basic nitrogen atoms. They are often found in plants, and are known for their complex ring structures and diverse pharmacological activities. Many alkaloids have been used in medicine for their analgesic, anti-inflammatory, and therapeutic properties. Examples of alkaloids include morphine, quinine, nicotine, and caffeine.
A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.
Chinese herbal drugs, also known as traditional Chinese medicine (TCM), refer to a system of medicine that has been practiced in China for thousands of years. It is based on the belief that the body's vital energy, called Qi, must be balanced and flowing freely for good health. TCM uses various techniques such as herbal therapy, acupuncture, dietary therapy, and exercise to restore balance and promote healing.
Chinese herbal drugs are usually prescribed in the form of teas, powders, pills, or tinctures and may contain one or a combination of herbs. The herbs used in Chinese medicine are typically derived from plants, minerals, or animal products. Some commonly used Chinese herbs include ginseng, astragalus, licorice root, and cinnamon bark.
It is important to note that the use of Chinese herbal drugs should be under the guidance of a qualified practitioner, as some herbs can interact with prescription medications or have side effects. Additionally, the quality and safety of Chinese herbal products can vary widely depending on the source and manufacturing process.
Calcitonin gene-related peptide (CGRP) is a neurotransmitter and vasodilator peptide that is widely distributed in the nervous system. It is encoded by the calcitonin gene, which also encodes calcitonin and catestatin. CGRP is produced and released by sensory nerves and plays important roles in pain transmission, modulation of inflammation, and regulation of blood flow.
CGRP exists as two forms, α-CGRP and β-CGRP, which differ slightly in their amino acid sequences but have similar biological activities. α-CGRP is found primarily in the central and peripheral nervous systems, while β-CGRP is expressed mainly in the gastrointestinal tract.
CGRP exerts its effects by binding to specific G protein-coupled receptors, which are widely distributed in various tissues, including blood vessels, smooth muscles, and sensory neurons. Activation of CGRP receptors leads to increased intracellular cyclic AMP levels, activation of protein kinase A, and subsequent relaxation of vascular smooth muscle, resulting in vasodilation.
CGRP has been implicated in several clinical conditions, including migraine, cluster headache, and inflammatory pain. Inhibition of CGRP signaling has emerged as a promising therapeutic strategy for the treatment of these disorders.
Capsaicin is defined in medical terms as the active component of chili peppers (genus Capsicum) that produces a burning sensation when it comes into contact with mucous membranes or skin. It is a potent irritant and is used topically as a counterirritant in some creams and patches to relieve pain. Capsaicin works by depleting substance P, a neurotransmitter that relays pain signals to the brain, from nerve endings.
Here is the medical definition of capsaicin from the Merriam-Webster's Medical Dictionary:
caпсаісіn : an alkaloid (C18H27NO3) that is the active principle of red peppers and is used in topical preparations as a counterirritant and analgesic.
Tetradium daniellii
Hypsilurus nigrigularis
Botanic Garden of Casimir the Great University, Bydgoszcz
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Euodia (plant)
Melicope vitiflora
Thomas Gilbert Henry Jones
Evoxine
Papilio liomedon
Tetradium
Papilio euchenor
Rutecarpine
Synephrine
Evodiamine
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Melicope xanthoxyloides
Lobesia fetialis
Alderney
The Real Housewives
List of psychoactive plants
Melicope rubra
Economy of the Han dynasty
Thalamiflorae
Zhang Heng
Tetradium ruticarpum
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Papilio krishna
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List of MeSH codes (B06)
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Rutaecarpa13
- One of the most popular and widely used natural remedies is Evodia rutaecarpa, also known as Wu Zhu Yu (or Wu Chu Yu). (bthrivingapi.com)
- Evodia rutaecarpa is also rich in antioxidants, which play a crucial role in preventing and treating oxidative damage. (bthrivingapi.com)
- Moreover, Evodia rutaecarpa has been found to have antimicrobial and antiviral properties. (bthrivingapi.com)
- The benefits of Evodia rutaecarpa don't stop there. (bthrivingapi.com)
- This means that Evodia rutaecarpa can help to increase metabolism, leading to weight loss. (bthrivingapi.com)
- In addition, Evodia rutaecarpa has been found to be an effective natural remedy for pain relief. (bthrivingapi.com)
- Furthermore, Evodia rutaecarpa is believed to be a natural remedy for anxiety and depression. (bthrivingapi.com)
- Sheu, JR 1999, ' Pharmacological effects of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa ', Cardiovascular Drug Reviews , 卷 17, 編號 3, 頁 237-245. (tmu.edu.tw)
- This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia-inducible factor 1 alpha, reactive oxygen species, prostaglandins, tumor necrosis factor, LIGHT, amyloid protein and orexigenic neuropeptides. (biomedcentral.com)
- Stimulation of calcitonin gene-related peptide release may partially explain the analgesic, cardiovascular and gastrointestinal protective, anti-obese activities of Evodia rutaecarpa and its major bioactive components. (biomedcentral.com)
- This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa ( Wuzhuyu ) and its major bioactive components such as dehydroevodiamine (DeHE), evodiamine (Evo) and rutaecarpine (Rut). (biomedcentral.com)
- Mechanisms of anti-inflammatory relative effects of Evodia rutaecarpa and its bioactive components are summarized in Additional file 1 . (biomedcentral.com)
- evaluated the protective effects of the natural molecule Evodiamine (EV) extracted from Evodia rutaecarpa in osteoarthritis through in vitro and in vivo experiments. (researchgate.net)
Hupehensis1
- Copacul de miere cu denumire stiintifica Evodia hupehensis este un arbore exotic originar din China centrala, In Romania Evodia se intalneste ca arbore ornamental in parcuri si gradini in zonele de litoral, campie si deal. (misugarden.ro)
Tetradium2
- Tetradium daniellii, the bee-bee tree or Korean evodia, is a species of flowering plant in the family Rutaceae. (wikipedia.org)
- Bee-bee tree, or Tetradium daniellii, is often referred to as Korean evodia. (gardenguides.com)
Evodiamine1
- Evodia fruits contain several bioactive alkaloids, including evodiamine and rutaecarpine, which are believed to be responsible for their numerous health benefits. (bthrivingapi.com)
Fruit1
- What are the benefits of Rutacarpine (from Evodia fruit)? (livepure.com)
Major1
- Wine-processed CR (wCR), zingiber-processed CR (zCR), and evodia-processed CR (eCR) are its major processed products. (bvsalud.org)
Wine1
- EVODIA is an exciting new project in the Denominacion de Origen Calatayud, hailed as one of Spain's most progressive and promising wine growing regions. (shopritewine.com)
Team1
- And after a longer break it is time again at the Kornati Cup 2023, with the BAVARIA CRUISER 46 "Evodia I" from Pitter Yachtcharter the BAVARIA RACING TEAM will start. (pitter-yachting.com)
Rutaecarpa Fruit Extract1
- Evodia rutaecarpa [Fruit] Extract [Std. (muscleandstrength.com)
Garnacha2
- Based on 100% Garnacha, the 2019 Evodia is a killer value that delivers incredible Garnacha flair at a crazy good price . (finewinehouse.com)
- This San Alejandro Evodia Old Vine Garnacha offers a lovely perfume of spice box, mineral, and wild cherry. (finewinehouse.com)
Setati1
- Authors Dr Thato Motlhalamme and Dr Evodia Setati follow the journeys of 14 award-winning and pioneering black women in Science, from their childhoods and education to their arrival in the upper echelons of various organisations, achieved through innovation, academic excellence, social intelligence, authentic leadership and tenacity. (findingada.com)
Fruit3
- Evodia (Evodiae Fructus) (fruit) [std. (allstarhealth.com)
- From fruit of Evodia rutaecarpa Hook. (drugfuture.com)
- Dried ripe fruit of Evodia ruticarpa that is used in DRUGS, CHINESE HERBAL . (nih.gov)
Evodiamine1
- Evodia fruits contain several bioactive alkaloids, including evodiamine and rutaecarpine, which are believed to be responsible for their numerous health benefits. (bthrivingapi.com)
RUTACEAE2
- Tetradium daniellii, the bee-bee tree or Korean evodia, is a species of flowering plant in the family Rutaceae. (wikipedia.org)
- Género de plantas de la familia RUTACEAE, usada en la medicina china (MEDICAMENTOS HERBARIOS CHINOS). (bvsalud.org)
Fragrance2
- Evodia is the Greek word for aroma or fragrance. (lazysnail.design)
- Forte Brands Holdings owns the natural and organic skincare, bath, body and home fragrance brands: Evodia Australia and Trelivings by Evodia which are already sold in major Australian department stores David Jones and Myer, pharmacies, gift and health stores, as well as a number of overseas countries. (professionalbeauty.com.au)
20211
- The 2021 Evodia comes from a cold year with snow, frost and some extreme temperatures (-18 degrees Celsius! (hamptonswineshoppe.com)
Juss1
- and Evodia rutaecarpa (Juss. (nih.gov)
Tree1
- Evodia (Evodia rutaecarpa) is a tree native to China and Korea. (vital.ly)
People1
- People use evodia for diarrhea, vomiting, stomach pain, and many other conditions, but there is no good scientific evidence to support these uses. (vital.ly)
Stop2
- Stop using evodia at least 2 weeks before a scheduled surgery. (vital.ly)
- The benefits of Evodia rutaecarpa don't stop there. (bthrivingapi.com)
Body3
- Chemicals in evodia might have many effects in the body, such as reducing pain, swelling, diarrhea, and blood pressure, and stimulating the heart. (vital.ly)
- Evodia might increase how quickly the body gets rid of caffeine. (vital.ly)
- Evodia might increase how quickly the body gets rid of chlorzoxazone. (vital.ly)
Pain1
- In addition, Evodia rutaecarpa has been found to be an effective natural remedy for pain relief. (bthrivingapi.com)
Effect1
- Among the plants tested Evodia rutaecarpa Bentham showed a strong inhibitory effect on acetylcholinesterase in vitro and an anti-amnesic effect in vivo. (nih.gov)
Increase2
- Taking evodia with these medications might increase the risk for a serious heart issue. (vital.ly)
- This means that Evodia rutaecarpa can help to increase metabolism, leading to weight loss. (bthrivingapi.com)
Brand2
- Raffellini, an experienced marketer with international credentials, will concentrate her efforts on building the Evodia brand and accelerating the company's expansion in Australia as well as New Zealand, Asia, Europe, South America and the US. (professionalbeauty.com.au)
- Visit www.evodia.com.au to find out more about the brand. (professionalbeauty.com.au)
Natural1
- Furthermore, Evodia rutaecarpa is believed to be a natural remedy for anxiety and depression. (bthrivingapi.com)