A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
An organoplatinum compound that possesses antineoplastic activity.
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
Tumors or cancer of the LUNG.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
Compounds that inhibit cell production of DNA or RNA.
Compounds that inhibit the activity of DNA TOPOISOMERASES.
Transplantation of an individual's own tissue from one site to another site.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
An anthracenedione-derived antineoplastic agent.
Therapeutic act or process that initiates a response to a complete or partial remission level.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The giving of drugs, chemicals, or other substances by mouth.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Disorders of the blood and blood forming tissues.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
Compounds that inhibit the activity of DNA TOPOISOMERASE I.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An antimitotic agent with immunosuppressive properties.
A decrease in the number of NEUTROPHILS found in the blood.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
A subnormal level of BLOOD PLATELETS.
The relationship between the dose of an administered drug and the response of the organism to the drug.
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Simultaneous resistance to several structurally and functionally distinct drugs.
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Absence of hair from areas where it is normally present.
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
A folate analog consisting of the pharmacologically active isomer of LEUCOVORIN.
A cell line derived from cultured tumor cells.
The action of a drug in promoting or enhancing the effectiveness of another drug.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.

Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. (1/3752)

The Mdm2 protein is frequently overexpressed in human non-seminomatous germ cell tumours and transitional carcinoma of the bladder where it may contribute to tolerance of wtp53. Mdm2 forms an autoregulatory feedback loop with p53; the Mdm2 gene is responsive to transactivation by p53 and once synthesized the Mdm2 protein terminates the p53 response. We show here that the topoisomerase poison etoposide, like ultra violet irradiation, inhibits Mdm2 synthesis. Cytotoxic concentrations of etoposide (IC90 for > 3 h) result in inhibition of Mdm2 induction at both the RNA and protein level. Rapid apoptosis ensues. Global transcription is not inhibited: p21waf-1/cip1 and GADD45 expression increase in a dose dependent manner. Inhibition of Mdm2 synthesis depends on the continuous presence of etoposide, suggesting the DNA damage may prevent transcription. Downregulation of Mdm2 transcript occurs in cells expressing HPV16-E6 suggesting that inhibition of Mdm2 transcription is p53-independent. When cells are -treated with a pulse (1 h) of etoposide and reincubated in drug free medium, Mdm2 synthesis commences immediately after damage is repaired (3 h) and the p53 response is attenuated. Induction of apoptosis and loss of clonogenicity are 3-5-fold lower under pulse treatment conditions. This is the first observation of inhibition of Mdm2 transcription following treatment with topoisomerase (topo II) poisons, a feature that may be useful in tumour types where p53 is tolerated by overexpression of Mdm2.  (+info)

1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage. (2/3752)

1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonal form of vitamin D, has anticancer activity in vivo and in vitro. Doxorubicin exerts its cytotoxic effect on tumor cells mainly by two mechanisms: (a) generation of reactive oxygen species (ROS); and (b) inhibition of topoisomerase II. We studied the combined cytotoxic action of 1,25(OH)2D3 and doxorubicin on MCF-7 breast cancer cells. Pretreatement with 1,25(OH)2D3 resulted in enhanced cytotoxicity of doxorubicin. The average enhancing effect after a 72-h pretreatment with 1,25(OH)2D3 (10 nM) followed by a 24-h treatment with 1 microg/ml doxorubicin was 74+/-9% (mean +/- SE). Under these experimental conditions, 1,25(OH)2D3 on its own did not affect cell number or viability. 1,25(OH)2D3 also enhanced the cytotoxic activity of another ROS generating quinone, menadione, but did not affect cytotoxicity induced by the topoisomerase inhibitor etoposide. The antioxidant N-acetylcysteine slightly reduced the cytotoxic activity of doxorubicin but had a marked protective effect against the combined action of 1,25(OH)2D3 and doxorubicin. These results indicate that ROS are involved in the interaction between 1,25(OH)2D3 and doxorubicin. 1,25(OH)2D3 also increased doxorubicin cytotoxicity in primary cultures of rat cardiomyocytes. Treatment of MCF-7 cells with 1,25(OH)2D3 alone markedly reduced the activity, protein, and mRNA levels of the cytoplasmic antioxidant enzyme Cu/Zn superoxide dismutase, which indicated that the hormone inhibits its biosynthesis. This reduction in the antioxidant capacity of the cells could account for the synergistic interaction between 1,25(OH)2D3 and doxorubicin and may also suggest increased efficacy of 1,25(OH)2D3 or its analogues in combination with other ROS-generating anticancer therapeutic modalities.  (+info)

p27Kip1 induces drug resistance by preventing apoptosis upstream of cytochrome c release and procaspase-3 activation in leukemic cells. (3/3752)

The cyclin-dependent kinase inhibitor p27Kip1 has been implicated as a drug resistance factor in tumor cells grown as spheroids or confluent monolayers. Here, we show that p27Kip1 overexpression also induces resistance to drug-induced apoptosis and cytotoxicity in human leukemic cells growing in suspension. The anti-apoptotic effect of p27Kip1 is not restricted to DNA-damaging agents but extends to the tubulin poison vinblastin, agonistic anti-Fas antibodies and macromolecule synthesis inhibitors. To further identify at which level this protein interferes with the cell death pathway, we investigated its influence on caspase activation and mitochondrial changes. Exposure of mock-transfected U937 cells to 50 microm etoposide activates procaspase-3 and the long isoform of procaspase-2 and induces mitochondrial potential decrease and cytochrome c release from mitochondria to the cytosol. All these events are prevented by p27Kip1 overexpression. p27Kip1 does not modulate Bcl-2, Bcl-X(L), Mcl-1 and Bax protein level in leukemic cells but suppresses Mcl-1 expression decrease observed in mock-transfected U937 cells undergoing etoposide-induced cell death. We conclude that p27Kip1 prevents cell death upstream of the final pathway common to many apoptotic stimuli that involves cytochrome c release from mitochondria and activation of downstream caspases.  (+info)

Bcl-2 overexpression results in reciprocal downregulation of Bcl-X(L) and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis. (4/3752)

Testicular germ cell tumours are hypersentive to chemotherapy and cell lines derived from these tumours are chemosensitive in vitro. We have previously shown that these cell lines express undetectable levels of the suppressor of apoptosis Bcl-2 and relatively high levels of the apoptosis inducer Bax (Chresta et al., 1996). To determine whether the absence of Bcl-2 in these cell lines makes them highly susceptible to drug-induced apoptosis, Bcl-2 was expressed ectopically in the 833K testicular germ cell tumour cell line. Stable overexpressing clones were isolated and three clones were studied further. Surprisingly, Bcl-2 overexpressing cells were sensitized to chemotherapy-induced apoptosis compared to the parental and vector control cells. Analysis of potential mechanisms of sensitization revealed there was a reciprocal downregulation of the endogenously expressed Bcl-X(L) in the Bcl-2 overexpressing clones. Downregulation of Bcl-X(L) to the same extent using antisense oligonucleotides enhanced etoposide-induced apoptosis by twofold. Our results indicate that Bcl-2 and Bcl-X(L) have different abilities to protect against chemotherapy-induced apoptosis in testicular germ cell tumours. In contrast to findings in some tumour cell types, Bcl-2 did not act as a gatekeeper to prevent entry of p53 to the nucleus.  (+info)

Effect of cellular ATP depletion on topoisomerase II poisons. Abrogation Of cleavable-complex formation by etoposide but not by amsacrine. (5/3752)

Topoisomerase (topo) II poisons have been categorized into ATP-independent and -dependent drugs based on in vitro studies. We investigated drug-induced topoII-DNA complexes in intact cells almost completely depleted of ATP. Virtually no DNA single-strand breaks (SSBs), as measured by alkaline elution, were detected in energy-depleted cells treated with the topoII poisons etoposide, teniposide, daunorubicin, doxorubicin, mitoxantrone, or clerocidin. This inhibition was reversible; subsequent incubation with glucose restored the level of DNA SSBs. The effect of ATP depletion was specific for topoII, because topoI-mediated cleavable complexes induced by camptothecin were unaffected by ATP depletion. Furthermore, etoposide-induced DNA-protein complexes and DNA double-strand breaks, as measured by filter elution techniques, and topoIIalpha and -beta trapping, as measured by a band depletion assay, were completely inhibited by energy depletion. Differences in drug transport could not explain the effect of ATP depletion. The topoII poison amsacrine (m-AMSA) was unique with respect to ATP dependence. In ATP-depleted cells, m-AMSA-induced DNA SSBs, DNA double-strand breaks, DNA-protein complexes, topoIIalpha and -beta trapping were only modestly reduced. The accumulation of m-AMSA was reduced in ATP-depleted cells, which indicates that drug transport could contribute to the modest decrease in m-AMSA-induced cleavable complexes. In conclusion, drug-induced topoII-DNA complexes were completely antagonized in ATP-depleted cells, except in the case of m-AMSA. One possible interpretation is that m-AMSA mainly produces prestrand passage DNA lesions, whereas the other topoII poisons tested exclusively stabilize poststrand passage DNA lesions in intact cells.  (+info)

Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage. (6/3752)

A sensitive and rapid in situ method was developed to visualize sites of single-stranded (ss) DNA in cultured cells and in experimental test animals. Anti-bromodeoxyuridine antibody recognizes the halogenated base analog incorporated into chromosomal DNA only when substituted DNA is in the single strand form. After treatment of cells with DNA-damaging agents or gamma irradiation, ssDNA molecules form nuclear foci in a dose-dependent manner within 60 min. The mammalian recombination protein Rad51 and the replication protein A then accumulate at sites of ssDNA and form foci, suggesting that these are sites of recombinational DNA repair.  (+info)

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. (7/3752)

Replication protein A (RPA) is a DNA single-strand binding protein essential for DNA replication, recombination and repair. In human cells treated with the topoisomerase inhibitors camptothecin or etoposide (VP-16), we find that RPA2, the middle-sized subunit of RPA, becomes rapidly phosphorylated. This response appears to be due to DNA-dependent protein kinase (DNA-PK) and to be independent of p53 or the ataxia telangiectasia mutated (ATM) protein. RPA2 phosphorylation in response to camptothecin required ongoing DNA replication. Camptothecin itself partially inhibited DNA synthesis, and this inhibition followed the same kinetics as DNA-PK activation and RPA2 phosphorylation. DNA-PK activation and RPA2 phosphorylation were prevented by the cell-cycle checkpoint abrogator 7-hydroxystaurosporine (UCN-01), which markedly potentiates camptothecin cytotoxicity. The DNA-PK catalytic subunit (DNA-PKcs) was found to bind RPA which was replaced by the Ku autoantigen upon camptothecin treatment. DNA-PKcs interacted directly with RPA1 in vitro. We propose that the encounter of a replication fork with a topoisomerase-DNA cleavage complex could lead to a juxtaposition of replication fork-associated RPA and DNA double-strand end-associated DNA-PK, leading to RPA2 phosphorylation which may signal the presence of DNA damage to an S-phase checkpoint mechanism. KEYWORDS: camptothecin/DNA damage/DNA-dependent protein kinase/RPA2 phosphorylation  (+info)

Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions. (8/3752)

A Ser740 --> Trp mutation in yeast topoisomerase II (top2) and of the equivalent Ser83 in gyrase results in resistance to quinolones and confers hypersensitivity to etoposide (VP-16). We characterized the cleavage complexes induced by the top2(S740W) in the human c-myc gene. In addition to resistance to the fluoroquinolone CP-115,953, top2(S740W) induced novel DNA cleavage sites in the presence of VP-16, azatoxin, amsacrine, and mitoxantrone. Analysis of the VP-16 sites indicated that the changes in the cleavage pattern were reflected by alterations in base preference. C at position -2 and G at position +6 were observed for the top2(S740W) in addition to the previously reported C-1 and G+5 for the wild-type top2. The VP-16-induced top2(S740W) cleavage complexes were also more stable. The most stable sites had strong preference for C-1, whereas the most reversible sites showed no base preference at positions -1 or -2. Different patterns of DNA cleavage were also observed in the absence of drug and in the presence of calcium. These results indicate that the Ser740 --> Trp mutation alters the DNA recognition of top2, enhances its DNA binding, and markedly affects its interactions with inhibitors. Thus, residue 740 of top2 appears critical for both DNA and drug interactions.  (+info)

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The Topo II inhibitor etoposide has been administered to women during pregnancy, with healthy babies born, although there are no data on the side-effects of etoposide on the reproductive system of these children, as none have yet reached puberty. Our results, using in vitro systems to assess the effects of etoposide, show that exposure of pre-follicular ovaries to etoposide results in a near-complete elimination of healthy follicles by the end of culture. This observed lack of follicles is a direct result of etoposide-treated pre-follicular germ cells failing to survive, with only a small proportion capable of forming follicles. Etoposide was used in concentrations considerably lower than those measured in the serum of patients, concentrations of 50-150 ng ml−1 being used, compared with 5-60 μg ml−1 in patient serum [38]. In contrast, exposure to oocytes once they were enclosed in follicles had no effect on total follicle numbers or health, the only effect seen on transitional follicles, ...
NOTE: *Patients who are unable to receive etoposide IV on day 2 may receive oral etoposide on days 2 and 3.. In both arms, chemotherapy (carboplatin and etoposide) repeats every 3 weeks for up to 6 courses. Patients receive thalidomide or placebo continuously for up to 2 years. Treatment continues in the absence of disease progression or unacceptable toxicity. Patients who experience disease progression may continue to receive thalidomide or placebo provided the patient is clinically and symptomatically stable.. Quality of life is assessed at baseline, during each course of chemotherapy, at 3-4 weeks after completion of chemotherapy, and at 6, 12, 18, and 24 months.. Patients are followed every 2 months for 2 years after the completion of chemotherapy and then every 3 months thereafter.. Peer Reviewed and Funded or Endorsed by Cancer Research UK. PROJECTED ACCRUAL: A total of 372 patients (186 per treatment arm) will be accrued for this study. ...
Etoposide may be at least as, or even more, effective and less myelotoxic when given in low doses over prolonged periods of time.. Patients receive low-dose oral etoposide on days 1 through 7 of every 2-week cycle. Patients who achieve a complete or partial response after two cycles and have no toxicity greater than grade 2 may have their dose escalated for subsequent cycles. If there are no responses to therapy among the first 14 evaluable patients, the study will close; if there is at least one objective response to therapy among the first 14 evaluable patients, enrollment will continue until all 41 patients are enrolled. Patients continue therapy until maximal tumor response (either stable disease or complete response) is achieved or disease progression occurs. ...
Supplementary MaterialsSupplementary figure. in medical trials.1 Although several immunotherapeutic and surgical strategies have already been created to boost the prognosis of cutaneous melanoma sufferers, such as for example checkpoint inhibitors, chimeric antigen receptor T-cell (CAR-T) immunotherapy, oncolytic infections and dendritic … Continue reading →. ...
Etoposide Injection by Fresenius: Etoposide belongs to the group of cancer-fighting medications called antineoplastics. Etoposide kills cancer cells by interfering with the genetic material DNA, which is necessary for their growth and reproduction. Etoposide is used alone or in combination with other antineoplastic medications to treat many types of cancer. These include certain types of lung cancer, lymphoma (cancer of the lymph cells), and cancers of the testicles.
Etoposide Injection USP, by Sandoz: Etoposide belongs to the group of cancer-fighting medications called antineoplastics. Etoposide kills cancer cells by interfering with the genetic material DNA, which is necessary for their growth and reproduction. Etoposide is used alone or in combination with other antineoplastic medications to treat many types of cancer. These include certain types of lung cancer, lymphoma (cancer of the lymph cells), and cancers of the testicles.
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Etoposide - Get up-to-date information on Etoposide side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Etoposide
Etoposide - Get up-to-date information on Etoposide side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Etoposide
Etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Etoposide is used to treat small cell lung cancer. It is usually given in combination with other cancer medicines. Etoposide may also be used for purposes not listed in this medication guide.
Paclitaxel and etoposide are two chemotherapy agents with broad cytotoxic activity and different mechanisms of action and resistance. Preclinical studies of their combined cytotoxicity have yielded conflicting results. We performed two sequential Phase II trials using different sequence schedules of paclitaxel and etoposide as first-line treatment in advanced non-small cell lung cancer (NSCLC). Forty-four patients with stage IIIB or IV NSCLC were included between July 1995 and September 1996. All patients received etoposide at 100 mg/m2, given as an i.v. infusion on days 1, 2, and 3. The first 20 patients (part A) also received paclitaxel at 175 mg/m2 as a 3-h infusion on day 1, immediately prior to etoposide. The subsequent 24 patients (part B) were given the same paclitaxel dose, but on day 4. Grade 3-4 granulocytopenia was seen in 70% of the patients in part A and in 37% of those in part B (P = 0.04). Twenty-five % of the courses in part A and 4% of the courses in part B were associated with ...
Reduction of atherosclerotic lesions in rabbits treated with etoposide associated with cholesterol-rich nanoemulsions Elaine R Tavares1, Fatima R Freitas1, Jayme Diament1, Raul C Maranhão1,21Heart Institute of the Medical School Hospital (InCor), University of São Paulo, São Paulo, Brazil; 2Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, BrazilObjectives: Cholesterol-rich nanoemulsions (LDE) bind to low-density lipoprotein (LDL) receptors and after injection into the bloodstream concentrate in aortas of atherosclerotic rabbits. Association of paclitaxel with LDE markedly reduces the lesions. In previous studies, treatment of refractory cancer patients with etoposide associated with LDE had been shown devoid of toxicity. In this study, the ability of etoposide to reduce lesions and inflammatory factors in atherosclerotic rabbits was investigated.Methods: Eighteen New Zealand rabbits were fed a 1% cholesterol diet for 60 days. Starting from day 30
Cisplatin, etoposide, and irinotecan may be clinically beneficial as a second-line chemotherapy for selected patients with small cell lung cancer (SCLC).
Our results are most consistent with a model for etoposide-induced gene rearrangement shown in Fig. 4C. In this model, etoposide induces DNA damage (Topo II-linked DSBs) somewhere in the chromsomes. Etoposide-induced DNA damage then activates the apoptotic signaling pathway, which leads to activation of caspase-3 followed by ICAD cleavage and activation of CAD. Activated CAD then cleaves DNA within the MLL bcr as well as within MLL partner genes. The repair of the DSB within the MLL bcr through NHEJ results in rearrangement of the MLL gene with one of its ,50 partner genes and hence t-AML.. The role of apoptotic nuclease in genome instability is a surprising finding. It is generally thought that apoptotic nucleases, such as CAD, play a role late in the apoptotic cell death program. Our results suggest that a population of apoptotic cells with activated CAD may escape cell death and survive with a few DSBs ( 15). A possible consequence of this escape is gene rearrangements. It should be pointed ...
Large interindividual variance has been observed in sensitivity to drugs. To comprehensively decipher the genetic contribution to these variations in drug susceptibility, we present a genome-wide model using human lymphoblastoid cell lines from the International HapMap consortium, of which extensive …
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Etoposide Pharmaswiss is a medicine available in a number of countries worldwide. A list of US medications equivalent to Etoposide Pharmaswiss is available on the Drugs.com website.
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Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Allergic reactions: Allergic reactions, including difficulty breathing and swelling of the throat and mouth, can occur with the use of this medication. Tell your doctor immediately if you experience any of these symptoms.. Blood clotting: This medication can reduce the number of platelet cells in the blood. Platelets help the blood to clot, and a shortage could make you bleed more easily. Tell your doctor of any signs that your blood is not clotting as quickly as usual. Such symptoms may include black and tarry stools, blood in the urine, easy bruising, or cuts that wont stop bleeding.. Infection: As well as killing cancer cells, etoposide can reduce the number of cells that fight infection ...
Both ATM and ATR display a preference for phosphorylating SQ/TQ motifs in their substrates (Kim et al., 1999; Traven and Heierhorst, 2005; Shiloh, 2006). ATR is predominantly activated by UV light and stalled replication forks, whereas ATM is specifically activated by DSBs of DNA, as seen after irradiation, etoposide, or oxidative stress (Abraham, 2001; Shiloh, 2006). In contrast, treatment with the ATP-competitive kinase inhibitor, staurosporine, does not activate ATM or affect the phosphorylation status of ATM-dependent substrates (Kamer et al., 2005). We show here that DNA-damaging agents, such as IR and etoposide, trigger MEF2D phosphorylation. Moreover, MEF2D phosphorylation only increased after etoposide exposure in wt-ATM cells but not in ATM-deficient cells. These results suggest that ATM mediates MEF2D phosphorylation in response to DSBs in DNA.. Furthermore, in the present study, RNA interference-mediated knockdown experiments in cerebellar granule cells indicate that endogenous MEF2D ...
Introduction: Vorinostat has been shown to potentiate DNA damage induced by topoisomerase II inhibitors in a sequence dependent fashion. A multi-center, open label phase I study with escalating doses of vorinostat in combination with etoposide was conducted to establish the safety of the combination in pediatric patients with refractory solid tumors to determine the maximum tolerated dose (MTD), dose limiting toxicity (DLT) and recommended phase II dose (RP2D) of this regimen.. Methods: Eligible patients were ≤21 years of age with relapsed/refractory solid tumors including central nervous system tumors. Study design consisted of a standard 3+3 dose escalation schema. Vorinostat was administered once daily for days 1-4 of the treatment cycle in escalating doses (125 mg/m2, 160 mg/m2, 210 mg/m2, and 270 mg/m2). Etoposide was administered at a fixed dose of 100 mg/m2/day on days 3-5 of the treatment cycle. Etoposide was administered 4 hours after administration of vorinostat. Each treatment cycle ...
Researchers studying etoposide (used in lung & testicular cancer, leukemias and brain tumors) showed that combining it with other compounds can improve outcomes.
Dose . BCCA Administration Guide : 0 . etoposide : 100 mg/m² . IV in 500 mL NS over 1 h (use non-DEHP equipment with in-line filter) 1 . mesna : 360 mg/m². ...
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This study is investigating ibrutinib and immuno-chemotherapy using dose-adjusted-temozolomide, etoposide, doxil, dexamethasone, ibrutinib, rituximab
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For the second time this month, the FDA has given an approval to Genentechs PD-L1 inhibitor, Tecentriq.. On March 18, 2019, the FDA awarded the immunotherapy agent, Tecentriq (atezolizumab; Genentech), in combination with chemotherapy (carboplatin and etoposide), approval for the first-line treatment of adults with extensive-stage small-cell lung cancer (ES-SCLC).. As evidence of the rapidity with which the immunotherapy field is gaining ground in cancer treatment, this new approval comes only 10 days after the drug received an accelerated approval (in combination with nab-paclitaxel) for the treatment of triple-negative breast cancer. Not only is this the second approval for atezolizumab in close succession to the first, but it is the first novel treatment in 2 decades for ES-SCLC, an aggressive and deadly malignancy.. This latest approval was based on data from the phase 3 IMpower133 trial, which was the first study to show that initial treatment with the immunotherapy-based combination ...
TY - JOUR. T1 - Evaluation of the continuous infusion of etoposide plus cisplatin in metastatic breast cancer a collaborative north central cancer treatment group/mayo clinic phase ii study. AU - Krook, James E.. AU - Loprinzi, Charles L.. AU - Schaid, Daniel J.. AU - Kardinal, Carl G.. AU - Mailliard, James A.. AU - Pfeifle, Delano M.. AU - Ellison, Neil M.. AU - Reuter, Nicholas F.. AU - Nelimark, Robert A.. N1 - Copyright: Copyright 2016 Elsevier B.V., All rights reserved.. PY - 1990/2/1. Y1 - 1990/2/1. N2 - A prospective clinical trial was done to evaluate the efficacy and toxicity of cisplatin plus etoposide (VP‐16) in patients with breast cancer who failed one previous chemotherapy regimen for advanced disease or relapsed within 12 months of adjuvant chemotherapy. Partial responses occurred in 11 of 44 evaluable patients (25%; 95% confidence interval (CI), 13% to 40%). The median time to disease progression in responding patients was 4 months (range, 3 to 6+ months), whereas the median ...
Radiotherapy improves the survival of patients with extensive-disease small-cell lung cancer: a propensity score matched analysis of Surveillance, Epidemiology, and End Results database Rui Zhang,* Ping Li,* Qin Li, Yunfeng Qiao, Tangpeng Xu, Peng Ruan, Qibin Song, Zhenming Fu Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China *These authors contributed equally to this work Background: The survival advantage of radiotherapy for patients with extensive-disease small-cell lung cancer (ED-SCLC) has not been adequately evaluated.Methods: We analyzed stage IV SCLC patients enrolled from the Surveillance, Epidemiology, and End Results (SEER) registry through January 2010 and December 2012. Propensity score analysis with 1:1 matching was performed to ensure well-balanced characteristics of all comparison groups. Kaplan–Meier and Cox proportional hazardous model were used to evaluate the overall survival (OS), cancer-specific survival (CSS), and corresponding 95% CI.Results: Overall,
To determine the efficacy of the addition of ifosfamide to cisplatin plus etoposide (VIP), or vinblastine (VeIP), in patients with recurrent germ cell tumors. DESIGN: Nonrandomized, prospective phase II trial. SETTING: Tertiary referral university hospital. PATIENTS: Fifty-six of fifty-eight entered patients with measurable and progressive recurrent germ cell tumors of testicular (46 patients), ovarian (1 patient), and extragonadal (9 patients) origin were evaluable for response after not being cured with cisplatin, vinblastine, and etoposide regimens. INTERVENTIONS: Patients were administered cisplatin (20 mg/m2 body surface area daily for 5 days), ifosfamide (1.2 g daily for 5 days), plus either etoposide (75 mg daily for 5 days) or vinblastine (0.11 mg/kg body weight on days 1 and 2). In addition, vigorous intravenous hydration therapy with normal saline (100 to 125 mL/h) was administered during the treatment course. Uroepithelial protective agents, N-acetylcysteine (orally) or mesna ...
During B cell activation, the DNA lesions that initiate somatic hypermutation and class switch recombination are introduced by activation-induced cytidine deaminase (AID). AID is a highly mutagenic protein that is maintained in the cytoplasm at steady state, however AID is shuttled across the nuclear membrane and the protein transiently present in the nucleus appears sufficient for targeted alteration of immunoglobulin loci. AID has been implicated in epigenetic reprogramming in primordial germ cells and cell fusions and in induced pluripotent stem cells (iPS cells), however AID expression in non-B cells is very low. We hypothesised that epigenetic reprogramming would require a pathway that instigates prolonged nuclear residence of AID. Here we show that AID is completely re-localised to the nucleus during drug withdrawal following etoposide treatment, in the period in which double strand breaks (DSBs) are repaired. Re-localisation occurs 2-6 hours after etoposide treatment, and AID remains in the
Supplementary MaterialsSupplementary Table 1. prolonged lifespan of was associated with decreased levels of daf-16 which related to the insulin/insulin-like growth factor signaling pathway (IIS) activity and reactive air types (ROS), whereas heat surprise transcription aspect-1 (hsf-1) pathway had not been … Continue reading →. ...
Tumors developed in BRCA1 mutation carriers show distinctive cytologic and molecular profiles compared with the sporadic tumor counterparts (1, 24). Nevertheless, at the moment, tailored treatments for this group of patients have only been partially investigated (12, 13). The rarity of human BRCA1-mutated cancer cell lines has further limited the exploitation of such approaches.. In the current study, we used the RNA interference technology to generate several isogenic BRCA1-silenced/nonsilenced breast cancer cell lines to assess whether a biological rational exists to implement therapeutic protocols specific for BRCA1 cancer patients. Our cell models were then challenged with several chemotherapeutics commonly used in breast cancer treatment.. We found no association between BRCA1 down-regulation and sensitivity to the topoisomerase II inhibitors etoposide and doxorubicin. Although differential response was observed in a few clones, this was not correlated to BRCA1 expression levels. ...
Although histone deacetylases (HDACs) are involved in the carcinogenesis of solid tumors and HDAC inhibitors (HDACi) have already proved their efficacy in clinical trials, isoenzyme specific functions are still ill defined. In this thesis a high expression of HDAC2 in vivo in human and murine pancreatic ductal adenocarcinomas (PDAC) was demonstrated, suggesting an important role of HDAC2 in the pathogenesis of PDAC. In pancreatic cancer cell lines a HDAC2 dependent signaling pathway was discovered which resulted in resistance towards the topoisomerase II inhibitor etoposide by repression of the BH3-only protein NOXA. Targeting HDAC2 by HDACi will therefore be a promising strategy to overcome therapeutic resistance of PDAC against DNA damage inducing chemotherapeutics. « ...
TY - JOUR. T1 - Chronic daily administration of oral etoposide - A phase I trial. AU - Hainsworth, J. D.. AU - Johnson, D. H.. AU - Frazier, S. R.. AU - Greco, F. A.. PY - 1989. Y1 - 1989. N2 - In this phase I study, we administered etoposide (VP-16) orally for 21 consecutive days to patients with advanced refractory cancers. All patients had received previous chemotherapy, and 50% of patients had received more than one combination regimen. When given for 21 consecutive days, the maximum-tolerated dose of oral VP-16 was 50 mg/m2/d. Myelosuppression was the dose-limiting toxicity, and occurred between days 21 and 28. In most patients, blood counts had recovered sufficiently by day 35 to begin another 3-week course. WBC count nadirs of , 1,000/μL occurred in four of 20 courses at this dose, and three patients required hospitalization for treatment of neutropenia and fever. Alopecia occurred in most patients; gastrointestinal (GI) and other toxicities were uncommon. Five of 16 patients with ...
Around 1 in 1,000 pregnant women are diagnosed with cancer, requiring consideration for the use of chemotherapy during pregnancy. However, little is known about the possible long-term detrimental effects of etoposide on the reproductive system of the unborn child. ...
This randomized phase II trial studies paclitaxel and carboplatin to see how well they work compared with bleomycin sulfate, etoposide phosphate, and cisplatin in treating patients with sex cord-ovarian stromal tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced) or has returned (recurrent). Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known which chemotherapy regimen is more effective in treating sex cord-ovarian stromal tumors. ...
The antitumor drug etoposide (ETO) is widely used in treating several cancers including adrenocortical tumor (ACT). the autophagy inhibitor reduced Take action cell growth and inhibited ETO-induced centrosome amplification. Chloroquine alleviated CDK2 and ERK but not Chk2 activation and thus inhibited centrosome amplification in either ETO- or hydroxyurea-treated ACT cells. In addition chloroquine also inhibited centrosome amplification in osteosarcoma U2OS cell lines when treated with ETO or hydroxyurea. In summary we have exhibited that chloroquine inhibited ACT cell growth and alleviated DNA damage-induced centrosome amplification by inhibiting CDK2 and ERK activity thus preventing genomic instability and recurrence of ACT. Introduction Adrenal gland which is composed of the cortex and medulla is the most important endocrine organ that lies on top of the kidney. Adrenocortex is the major site of steroidogenesis in response to adrenocorticotropic hormone stimulation and its abnormal growth ...
Dose escalation study of high-dose carboplatin and etoposide with autologous bone marrow support in patients with recurrent and refractory germ cell tumors.: Th
Background: In an attempt to reduce the toxicity of chemotherapy in good-risk testicular cancer patients the two drug combinations, cisplatin plus etoposide (EP) and carboplatin plus etoposide (EC), have been compared. Methods: Good risk was defined according to the MSKCC and IU criteria. 39 Patients have been treated with EP (cisplatin 20 mg/m2 i.v. and etoposide 100 mg/m2 i.v. on days 1 to 5), and 23 patients received EC (carboplatin 350 mg/m2 on day 1 and etoposide 100 mg/m2 on days 1 to 5). Four cycles of chemotherapy were given at 21- and 28-day intervals, respectively, with delays of up to 7 days in istances of leukocyte counts less than 3.0 x 10(9)/l or platelet counts less than 100 x 10(9)/l. Results: In the EP group 34 (87%) of 39 patients achieved CR (26 with chemotherapy alone, 8 with additional surgery). After a median follow-up of 26 (12-58) months 3 (9%) patients relapsed from CR. Currently 38 patients are alive, and 37 (94%) are NED. In the EC group 20 (87%) of 23 patients ...
The tumor suppressor gene HIC1 (Hypermethylated In Cancer 1) encodes a transcriptional repressor mediating the p53-dependent apoptotic response to irreparable DNA double-strand breaks (DSBs) through direct transcriptional repression of SIRT1. HIC1 is also essential for DSB repair as silencing of endogenous HIC1 in BJ-hTERT fibroblasts significantly delays DNA repair in functional Comet assays. HIC1 SUMOylation favours its interaction with MTA1, a component of NuRD complexes. In contrast with irreparable DSBs induced by 16-hours of etoposide treatment, we show that repairable DSBs induced by 1 h etoposide treatment do not increase HIC1 SUMOylation or its interaction with MTA1. Furthermore, HIC1 SUMOylation is dispensable for DNA repair since the non-SUMOylatable E316A mutant is as efficient as wt HIC1 in Comet assays. Upon induction of irreparable DSBs, the ATM-mediated increase of HIC1 SUMOylation is independent of its effector kinase Chk2. Moreover, irreparable DSBs strongly increase both the
Twenty three patients with paediatric soft tissue sarcomas who had relapsed or refractory disease were treated with a rapid schedule of intravenous etoposide (100 mg/m2 daily on three consecutive days, weekly over 3 weeks). The regimen was well tolerated with predictable myelotoxicity. In 19 patients with rhabdomyosarcoma, there was a response rate of 42%. This appears to be better than previously reported with conventional three weekly schedules. These data indicate that for rhabdomyosarcoma, as for some other tumours, a divided dose regimen may be the optimal schedule and is worthy of further evaluation ...
Etoposide injection is used in combination with other medications to treat cancer of the testicles that has ... after treatment with other medications or radiation therapy. Etoposide injection is also used in combination with other ...
Transposase activity was thought to be extinct in humans because DNA movement can be deleterious in higher organisms, resulting in genomic instability and perha...
Etoposide is a widely used anticancer drug successfully used for the treatment of many types of cancer in children and adults. Its use, however, is associated with an increased risk of development of secondary acute myelogenous leukemia involving the mixed-lineage leukemia (MLL) gene (11q23) translocations. Previous studies demonstrated that the phenoxyl radical of etoposide can be produced by action of myeloperoxidase (MPO), an enzyme found in developing myeloid progenitor cells, the likely origin for myeloid leukemias. We hypothesized, therefore, that one-electron oxidation of etoposide by MPO to its phenoxyl radical is important for converting this anticancer drug to genotoxic and carcinogenic species in human CD34+ myeloid progenitor cells. In the present study, using electron paramagnetic resonance spectroscopy, we provide conclusive evidence for MPO-dependent formation of etoposide phenoxyl radicals in growth factor-mobilized CD34+ cells isolated from human umbilical cord blood and ...
Objectives To compare the efficacy of rituximab, dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (DA-EPOCH-R) with traditional rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) regimens in CD5+ double-hit lymphoma (DHL) and to evaluate prognostic factors. PFS (85.7% vs 23.0%, em P /em =0.029), but there was no statistical difference in OS (87.7% vs 34.4.0%, em P /em =0.064). However, in DA-EPOCH-R protocol, there was no significant difference between CD5+ DHL (MYC/BCl2 and MYC/BCL6) and triple-hit lymphoma ( em buy IWP-2 P /em =0.776 for PFS; em P /em =0.728 for OS). Multivariate analysis showed that CD5+ treatment regimen and disease stage were independent prognostic factors. Conclusion Our retrospective study shows that CD5+ has a poorer prognosis than CD5? patients. Based on its improved lifetime and good tolerance on CD5+ patients, which is expected to become the first-line treatment for high-risk DLBCL types based on more ...
In this international, double-blind, phase 3 trial, adults with newly diagnosed ES-SCLC, ECOG PS ≤ 1, and no previous systemic therapy for SCLC are randomized 1:1 to receive either EP plus a 200-mg fixed dose of pembrolizumab intravenously (IV) once every 3 weeks (Q3W) or EP plus pbo IV Q3W. Randomization is stratified by the chosen platinum therapy (carboplatin vs cisplatin), ECOG PS (0 vs 1), and baseline lactate dehydrogenase concentration (≤ upper limit of normal [ULN] vs > ULN). Study treatment includes a total of 4 cycles of EP and 2 y of pembrolizumab/pbo and continues until documented PD, intolerable toxicity, or withdrawal of consent. Pts with a response after 4 cycles of EP plus pbo or pembrolizumab may receive prophylactic cranial irradiation. Pts who complete 2 y of pembrolizumab treatment or stop pembrolizumab for reasons other than PD/intolerability, but subsequently have documented PD, may receive an additional 1 y of pembrolizumab. Tumor response is assessed every 6 wk for 48 ...
Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
The present invention provides amphiphilic prodrugs comprising a therapeutic compound conjugated to an PEG-oligomer/polymer and methods for using said prodrugs to enable oral drug delivery and/or delivery of drugs across the blood brain barrier into the central nervous system.
An etoposide-treated DU145 prostate cancer cell exploding into a cascade of apoptotic bodies. The sub images were extracted from a 61-hour time-lapse microscopy video, created using quantitative phase-contrast microscopy. The optical thickness is color-coded. With increasing thickness, color changes from gray to yellow, red, purple and finally black.[1] ...
Golf great Phil Mickelson has been finding it a struggle on the course in recent weeks so could have done without a freak occurrence which left his participation in the final round of the BMW Championship at Medinah in some doubt. Teenage girls have designed Africas first private satellite due to launch into space in 2017. Its hoped it can monitor and find answers to South Africas drought crisis. There are currently1277 DSP recipients who list their only medical condition asdrug or alcohol dependence, official figures have revealed. 1000 mg generic avamigran ...
This is a multinational, multicenter, randomized controlled, open-label, adaptive study to evaluate the efficacy of PaCE chemotherapy in chemotherapy na
Jack Yalowich, PhD, is a member of the Translational Therapeutics Program at OSUCCC - James, where his research focuses on therapeutic treatment and prevention of cancers. In particular, he is exploring how to improve ability of the clinically effective anticancer agent etoposide (VP-16) in
Just a quickie today. Erin had blood counts done yesterday. It was Day 11 of 21 days (hump day for this cycle). With all the chemos Erin has done in the past Day 11 was usually a pretty important day. It was the day Erin was most likely to have the lowest white blood counts and be the most susceptible to germs or infections. We tended to keep a low profile on Days 10 to Day 13 or so, just to be on the safe side. I knew that oral etoposide was supposed to be easy on the counts, but so was topo/cyclo. Even with neulasta support (the injection to build her white counts), with topo/cyclo her ANC would drop down under 1000 every time. [To refresh your memory, normal ANC is over 2000. Under 500 is considered neutropenic and requires her to stay home from school, etc. ] With the etoposide, she didnt have the benefit of neulasta (thats akin to saying she doesnt have the benefit of being beaten with a stick), and she has bone marrow that has faced down almost a year of toxic chemo. ...
Despite the premature end of her first chemotherapy cycle, Sadie remained remarkably stable. Between no etoposide and lots of dexamethasone, she was feeling great. We wondered if wed heard the doctors correctly on August 27th. Sadie didnt look like someone with only weeks to live.. Sadies second chemotherapy cycle should have started on September 18, but her bloodwork wasnt good enough. She did have an MRI that day, a month ahead of schedule. The MRI confirmed her prognosis: the tumor had grown dramatically since Sadies last MRI. What cisplatinum and etoposide shed gotten were having no effect. On September 22, the doctors recommended we stop treatment and enjoy the time Sadie had left. Sadie and we concurred.. We went home. Wed cried on August 27th, but today we were just numb. Her prognosis wasnt new, and despite the hard evidence in black-and-white MRI images, it still seemed unreal. I remember feeling mostly relieved that Sadie wouldnt be so miserably sick now that chemotherapy was ...
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Background: IIIA T1N2M0 NSCL Lung Cancer. 10/2013 URL Removal followed up with chemoradiation; Radiation to Mediastinum and area of lobectomy. Carbo/Taxol concurrent with 35 radiation treatments; Chemo only 3 treatments - allergic reaction to Taxol replaced with 3 treatments of Cisplatin/Etoposide. 4 months post treatment, ER visit and Pulmonary DR visit follow-up for extreme
NU7441, also known as KU-57788, is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB.
Page 2 - Okay, this is really bugging me. My friend (and coworker) had to give Etoposide the other night. And like a good little doo-bee, she looked up the med on the hospitals computerized drug reference
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
Ifosfamide and etoposide in childhood osteosarcoma. A phase II study of the French Society of Paediatric Oncology. „Eur J ... Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with ... Phase 2 trial of two courses of cyclophosphamide and etoposide for relapsed high-risk osteosarcoma patients. „Cancer". 115 (13 ...
Etopophos (etoposide). *Ixempra (ixabepilone). *Lysodren (mitotane). *Megace (megestrol acetate). *Opdivo (nivolumab) is a ...
cisplatin, etoposide, bleomycin non-seminomatous germ cell tumors PEI cisplatin, etoposide, ifosfamide small-cell lung ... etoposide, platinum agent testicular cancer, germ cell tumors EPOCH etoposide, prednisone, vincristine (Oncovin), ... bleomycin, etoposide, platinum agent testicular cancer, germ cell tumors CA cyclophosphamide, doxorubicin (Adriamycin) (same as ... ifosfamide, carboplatin, etoposide (VP-16) aggressive lymphomas, progressive neuroblastoma ICE-R or R-ICE or RICE ICE + ...
Examples of chemotherapy treatments that can lead to dysgeusia are cyclophosphamide, cisplatin, and etoposide. The exact ...
Secondary leukaemia, which may include AML-M5, has been associated with exposure to epipodophyllotoxins, such as etoposide.[2] ... Oct 1998). "Secondary leukemia following high cumulative doses of etoposide in patients treated for advanced germ cell tumors ...
Mayapple can be also used topically as an escharotic in removing warts, and two of its derivatives, etoposide and teniposide, ... have shown promise in treating some cancers.[21][22] Etoposide is among the World Health Organisations's list of essential ...
Etoposide has also been shown to decrease docetaxel clearance, though patient numbers for this observation have been low.[13] ... etoposide, and vinblastine are all potentially co-administered with docetaxel and did not modify docetaxel plasma binding in ...
Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and ...
Vincristine and Etoposide, apart from AZT. In 1995, when Rao set out to establish his own research centre, Avra Laboratories, ...
"Phase III study of pemetrexed plus carboplatin compared with etoposide plus carboplatin in chemotherapy-naive patients with ... "Phase II study of cisplatin plus etoposide and bevacizumab for previously untreated, extensive-stage small-cell lung cancer: ...
... etoposide, and high-dose cytarabine); COMB (i.e. cyclophosphamide, oncovin, methyl-CCNU, and bleomycin); and infusional EPOCH ( ... CHOP plus etoposide); hyper-CVAD-MA (i.e. cyclophosphamide, vincristine, doxorubicin, dexamethasone and high dose methotrexate ... i.e. etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin). While the experience treating PBL with radiation ...
etoposide and doxorubicin. In high doses it was found to be strongly toxic to normal cells. This effect may be responsible for ...
Etoposide - a topoisomerase inhibitor. Fludarabine and cytosine are less effective than standard ADE chemotherapy in high-risk ...
Etoposide - a topoisomerase inhibitor. A phase II trial of mesna / ifosfamide, mitoxantrone and etoposide for refractory ...
Etoposide · Teniposide); 3a. Anthracyclines (Aclarubicin · Daunorubicin · Doxorubicin · Epirubicin · Idarubicin · Amrubicin · ...
Etoposide - a topoisomerase inhibitor. Cycles are repeated every 14 days for 3 cycles, then high-dose chemotherapy with ... and Etoposide: A Highly Effective Cytoreduction and Peripheral-Blood Progenitor-Cell Mobilization Regimen for Transplant- ...
These include etoposide and teniposide. They act as anti-cancer drugs by inhibiting topoisomerase II. Podophyllotoxin Takimoto ...
Cisplatin and etoposide, Carboplatin and etoposide. The drug paclitaxel may be useful in the treatment of cisplatin-resistant ... In this study, patients with ES-SCLC were treated with standard carboplatin plus etoposide and were randomized to receive ... First-line treatment is usually with cisplatin and etoposide. In Japan, first-line treatment is shifting to irinotecan and ... Paclitaxel-based chemotherapy showed modest activity in SCLC patients refractory to both etoposide- and camptothecin-based ...
"Altered expression of glycoproteins on the cell surface of Jurkat cells during etoposide-induced apoptosis: shedding and ...
... after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide ...
Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene. This gene has higher expression ... "Entrez Gene: EI24 etoposide induced 2.4 mRNA". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap ...
It is chemically similar to the anti-cancer drug etoposide, being distinguished only by a thienyl rest where etoposide has a ...
... which in this particular case use a combinatorial therapy of etoposide and cisplatin chemotherapy to save the 32-year old ...
... postmenopausal Ethanol in alcoholic beverages4 Erionite Ethylene oxide Etoposide alone, and in combination with cisplatin and ...
... etoposide, cyclophosphamide, bleomycin VAPEC-B). Alemtuzumab (Campath), a monoclonal antibody that attacks white blood cells, ...
... etoposide, bleomycin (VAPEC-B). Alemtuzumab (Campath), an anti-CD52 monoclonal antibody that attacks white blood cells, has ...
A few years later, in November 1983, etoposide was approved by the U.S. Food and Drug Administration. Etoposide is still ... etoposide, Vepesid, discovered on 21 October 1966), which remains very clinically successful. Teniposide and etoposide were ... there are an astonishing number of coincidences between etoposide and cyclosporine. The first coincidence was that etoposide ... After a landmark clinical comparative analysis by F. Muggia and M. Rozencweig, etoposide and teniposide were licensed to ...
Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation ... Keywords:buy Etoposide (VP-16) , Etoposide (VP-16) Supplier , purchase Etoposide (VP-16) , Etoposide (VP-16) cost , Etoposide ( ... Etoposide (VP-16) Topoisomerase II inhibitor Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which ... VP16, Vepesid, etoposide phosphate. SMILES code. C[[email protected]@H]1OC[[email protected]@H]2[[email protected]@H](O1)[[ ...
Etoposide: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking etoposide,. *tell your doctor and pharmacist if you are allergic to etoposide, any other medications, or any of ... You should not become pregnant or breast-feed while you are taking etoposide. If you become pregnant while taking etoposide, ... Etoposide comes as a capsule to take by mouth. It is usually taken once a day for 4 or 5 days in a row. This cycle may be ...
Etoposide Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before receiving etoposide injection,. *tell your doctor and pharmacist if you are allergic to etoposide, etoposide phosphate ( ... If you become pregnant while receiving etoposide injection, call your doctor. Etoposide may harm the fetus. ... or any of the ingredients in etoposide or etoposide phosphate injection. Ask your pharmacist for a list of the ingredients. ...
Etoposide is in the topoisomerase inhibitor family of medication. It is believed to work by damaging DNA. Etoposide was ... "Etoposide". Drug Information Portal. U.S. National Library of Medicine. "Etoposide phosphate". Drug Information Portal. U.S. ... It is used in form of its salt etoposide phosphate. Etoposide was first synthesized in 1966 and U.S. Food and Drug ... "Etoposide". National Cancer Institute. "Etoposide". NCI Drug Dictionary. National Cancer Institute. Medicine portal. ...
A list of US medications equivalent to Etoposide Pharmaswiss is available on the Drugs.com website. ... Etoposide Pharmaswiss is a medicine available in a number of countries worldwide. ... Ingredient matches for Etoposide Pharmaswiss. Etoposide. Etoposide is reported as an ingredient of Etoposide Pharmaswiss in the ... Etoposide Pharmaswiss. Etoposide Pharmaswiss may be available in the countries listed below. ...
This page contains brief information about etoposide phosphate and a collection of links to more information about the use of ... More About Etoposide Phosphate. Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for ... MedlinePlus Information on Etoposide Phosphate - A lay language summary of important information about this drug that may ... This page contains brief information about etoposide phosphate and a collection of links to more information about the use of ...
Etoposide and cisplatin chemotherapy, known as EP (or sometimes PE), is used to treat many cancers. Find out more about the ... Days two and three - you have a drip of etoposide, or etoposide capsules to take. ... Etoposide may affect your skin. Your doctor or nurse can tell you what to expect. If your skin feels dry, try using an ... Etoposide can cause a rash, which may be itchy. Your skin may darken. It will return to its normal colour after you finish ...
Carboplatin and etoposide chemotherapy is used to treat small cell cancers, including small cell lung cancer, small cell ... How carboplatin and etoposide are given. You will be given carboplatin and etoposide in the chemotherapy day unit or during a ... What is carboplatin and etoposide?. Carboplatin and etoposide chemotherapy is used to treat small cell cancers, including: * ... Etoposide is given as a drip over an hour, but you can also take etoposide as capsules. ...
Etoposide (US and Canadian brand name VePesid, also known as VP-16) is a chemotherapy agent used in the treatment of several ... Etoposide (US and Canadian brand name VePesid, also known as VP-16) is a chemotherapy agent used in the treatment of several ... Etoposide can cause nausea and vomiting. Your doctor may prescribe additional medications to help with this. The drug also may ... It is derived from the mayapple plant (Podophyllum peltatum). Etoposide blocks the cell reproduction cycle by disruption of ...
Re-localisation occurs 2-6 hours after etoposide treatment, and AID remains in the nucleus for 10 or more hours, during which ... Here we show that AID is completely re-localised to the nucleus during drug withdrawal following etoposide treatment, in the ... Analysis of DSB dynamics shows that AID is re-localised in response to etoposide treatment, however re-localisation occurs ...
... ,Antitumour agent and DNA-topoisomersae II inhibitor (IC50 = 59.2 M). IUPAC: [5R-, ...
Topoisomerase II inhibitors: Amsacrine, etoposide, etoposide phosphate, teniposide. Note: We strongly encourage you to talk ... The amount of etoposide that you will receive and the method it is given depends on many factors, including your height and ... Pregnancy category D (etoposide may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the ... Etoposide is considered an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is ...
Etoposide is used to treat small cell lung cancer. It is usually given in combination with other cancer medicines. Etoposide ... Etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. ... What is etoposide?. Etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. ... What should I discuss with my healthcare provider before taking etoposide?. You should not use etoposide if you are allergic to ...
Etoposide is used to treat cancer of the lung or testicles. It is usually given with other cancer medicines in a combination ... Etoposide may also be used for purposes not listed in this medication guide. ... Etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. ... What should I avoid while receiving etoposide?. Do not receive a "live" vaccine while using etoposide. The vaccine may not work ...
Find information on Etoposide Phosphate (Etopophos) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... etoposide phosphate is a topic covered in the Daviss Drug Guide. To view the entire topic, please sign in or purchase a ... "Etoposide Phosphate." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Washington Manual, www.unboundmedicine.com/ ... washingtonmanual/view/Davis-Drug-Guide/109245/all/etoposide_phosphate. Quiring C, Sanoski CA, Vallerand AH. Etoposide phosphate ...
The worlds largest personalized health network that helps people find new treatments, connect with others and take action to improve their outcomes.
Etoposide is an antineoplastic chemotherapy medication used in combination with other medications to treat testicular and small ... How to Take Etoposide. Etoposide is given by intravenous (IV, into a vein) infusion. It can also be given by mouth in the form ... About: Etoposide (Toposar®, VePesid®, Etopophos®,VP-16) Etoposide works by blocking the action of an enzyme in cells called ... Possible Side Effects of Etoposide. There are a number of things you can do to manage the side effects of etoposide. Talk to ...
Etoposide Etoposide is used in combination with other medications to treat a certain type of lung cancer (small cell lung ... Etoposide Injection Etoposide injection is used in combination with other medications to treat cancer of the testicles that has ... Estring), and others.MajorDo not take this combination.Etoposide (VePesid)Grapefruit might decrease how much etoposide (VePesid ... Durvalumab injection is also used in combination with etoposide (Etopophos) and either carboplatin or cisplatin to treat ... ...
... provides information about interactions between Quinidine Gluconate Oral and selected-p-glycoprotein-p-gp-inhibitors-etoposide. ... Etoposide pathway. Pharmacogenet Genomics 2009 Jul;19(7):552-3.. *3.Lagas JS, Fan L, Wagenaar E, Vlaming ML, van Tellingen O, ... Etoposide/Selected P-glycoprotein (P-gp) Inhibitors Interactions. This information is generalized and not intended as specific ... Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug ...
Etoposide is also active in malignant lymphomas of both Hodgkins and non Hodgkins type and acute leukaemias. In addition, it is ... Etoposide induces an irreversible blockade of cells in the premitotic phases of cell cycle leading to accumulation of cells in ... Etoposide exerts its cytotoxic effect by interfering with the scission-reunion reaction of the enzyme topoisomerase II. The ... Etoposide also inhibits the transport of nucleosides across the plasma membrane. Hence it exerts its cytotoxic effect by ...
This complication is age related but not related to the amount of etoposide exposure. Therefore, we must consider the ... of patients treated with etoposide at the time of LHRH study, though pituitary function was preserved. ... Reproductive status in GTD treated with etoposide J Reprod Med. 1997 Feb;42(2):104-10. ... Study design: Forty-seven patients with low-risk GTD were treated with etoposide alone, and pituitary-ovarian function was ...
Etoposide, (5a alpha,9 alpha)-Isomer , Etoposide, (5a alpha)-Isomer , Etoposide, (5S)-Isomer , Etoposide, alpha D ... Etoposide 2.. Chemicals ← Polycyclic Compounds ← Polycyclic Aromatic Hydrocarbons ← Naphthalenes ← Tetrahydronaphthalenes ← ... Glucopyranosyl Isomer , Etoposide, alpha-D-Glucopyranosyl Isomer , Etoposide Pierre Fabre , Etoposide Teva , Etoposido Ferrer ... Etoposide CAS Type 1 Name Furo(3,4:6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)- ...
Further information: Etoposide (injection) and Etoposide (injection). Further information: Etoposide (oral) and ... Retrieved from "https://www.wikidoc.org/index.php?title=Etoposide&oldid=1100632" ...
Hints: Click on a [map] link to show a map of that region. Click on a [studies] link to search within your current results for studies in that region. Use the back button to return to this list and try another region. Studies with no locations are not included in the counts or on the map. Studies with multiple locations are included in each region containing locations ...
We describe a case of a patient on etoposide and ifosfamide who presented with unilateral vision loss, anemia, and ... Etoposide and ifosfamide are chemotherapeutic agents used frequently in the treatment of sarcomas and hematologic malignancies ... L. Schacter, "Etoposide phosphate: what, why, where, and how?" Seminars in Oncology, vol. 23, supplement 13, no. 6, pp. 1-7, ... Etoposide is a topoisomerase inhibitor that interferes with the unwinding of DNA during replication [8]. Ifosfamide is an ...
Drug Information available for: Etoposide Etoposide phosphate Genetic and Rare Diseases Information Center resources: ... Etoposide. Etoposide phosphate. Antineoplastic Agents, Phytogenic. Antineoplastic Agents. Topoisomerase II Inhibitors. ... Etoposide in Treating Young Patients With Relapsed Ependymoma. The safety and scientific validity of this study is the ... Patients receive etoposide IV over 1 hour on days 1-3, 8-10, and 15-17. Treatment repeats every 28 days for up to 6 courses in ...
... Proc Natl Acad Sci U S A ... Cell growth inhibition at increasing concentrations of etoposide for 72 h was determined by using alamarBlue assay. Gene ... The analysis identified 63 genetic variants that contribute to etoposide-induced toxicity through their effect on gene ... and genes not yet known to be associated with sensitivity to etoposide. This unbiased method can be used to elucidate genetic ...
Find information about Etoposide including usage and side effects. Browse our Drug Dictionary for generic drug names and brand ... Etoposide is used to treat people who have certain types of blood cancer including Hodgkin and non-Hodgkin lymphoma. It is FDA ... Patients Disease Information Treatment Types of Treatment Chemotherapy and Other Drug Therapies Drug Listings Etoposide ...
Etoposide belongs to the group of cancer-fighting medications called antineoplastics. Etoposide kills cancer cells by ... Etoposide is used alone or in combination with other antineoplastic medications to treat many types of cancer. These include ... Etoposide capsules should be taken on an empty stomach. Etoposide often causes nausea and vomiting, but it is very important ... Etoposide belongs to the group of cancer-fighting medications called antineoplastics. Etoposide kills cancer cells by ...
Isono T, et al. A Case of small cell lung cancer with anti-transcription intermediary factor 1 (TIFl)-gamma antibody-positive Dermatomyositis as paraneoplastic syndrome. Haigan / Japanese Journal of Lung Cancer 59: 158-162, No. 2, Apr 2019. Available from: URL: http://doi.org/10.2482/haigan.59.158 [Japanese;summarised from a translation] - Japan ...
  • OBJECTIVES: I. Determine toxic effects of repeated courses of altretamine plus etoposide at the maximum tolerated dose (MTD). (knowcancer.com)
  • Comparison of carboplatin plus etoposide with amrubicin monotherapy for extensive-disease small cell lung cancer in the elderly and patients with poor performance status. (bioportfolio.com)
  • Carboplatin plus etoposide (CE) is a standard treatment for elderly patients with extensive-disease small cell lung cancer (ED-SCLC). (bioportfolio.com)
  • Patients with advanced, previously-untreated thymoma (Masaoka classification), measurable disease, and a performance status of 0-2 were eligible, and were treated with cisplatin-plus-etoposide, together with radiotherapy when possible. (nih.gov)
  • Therefore, she was started on third-line chemotherapy with cisplatin plus etoposide. (deepdyve.com)
  • The chemotherapy with cisplatin plus etoposide was continued for a further 4 courses but the metastatic lesions developed into progressive disease. (deepdyve.com)
  • Author comment: 'Therefore, the regimen was changed to cisplatin plus etoposide (EP) as the third-line chemotherapy. (deepdyve.com)
  • PURPOSE: Phase I trial to study the effectiveness of nitrocamptothecin plus etoposide in treating patients who have advanced solid tumors. (clinicalconnection.com)
  • The patients were randomly assigned in a 1:1 ratio to receive carboplatin plus etoposide (n=81) or oral topotecan (n=81). (physiciansweekly.com)
  • Aims: Carboplatin plus etoposide has modest efficacy in docetaxel-pretreated castration-resistant prostate cancer patients. (ovid.com)
  • Conclusion: Our preliminary findings support the hypothesis that carboplatin plus etoposide may yield some clinical benefit in a population of patients who failed all currently approved therapeutic options for prostate cancer. (ovid.com)
  • To determine the efficacy of the addition of ifosfamide to cisplatin plus etoposide (VIP), or vinblastine (VeIP), in patients with recurrent germ cell tumors. (uni-bonn.de)
  • Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer. (wikipedia.org)
  • Etoposide (US and Canadian brand name VePesid, also known as VP-16) is a chemotherapy agent used in the treatment of several cancers including Hodgkin's Lymphoma / Disease and Non-Hodgkin's lymphoma . (lymphomainfo.net)
  • Etoposide (VePesid)Grapefruit might decrease how much etoposide (VePesid) the body absorbs. (nih.gov)
  • The lowest price for Etoposide (Vepesid) 20 mg/ml is $17.86 per ml for 50 mls at PharmacyChecker-accredited online pharmacies. (pharmacychecker.com)
  • Determined to improve patients' quality of life with a convenient, well-tolerated, and efficacious treatment, the investigators designed an oral chemotherapy regimen consisting of 28-day cycles of etoposide (VePesid) and uracil/tegafur (UFT) plus leucovorin (UFT/LV, also known as Orzel, investigational). (cancernetwork.com)
  • Etoposide injection should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. (medlineplus.gov)
  • Etoposide is used as a form of chemotherapy for cancers such as Kaposi's sarcoma, Ewing's sarcoma, lung cancer, testicular cancer, lymphoma, nonlymphocytic leukemia, and glioblastoma multiforme. (wikipedia.org)
  • Etoposide and cisplatin, known as EP (or sometimes PE), is a combination chemotherapy treatment used to treat different cancers. (macmillan.org.uk)
  • Carboplatin and etoposide chemotherapy is used to treat small cell cancers, including small cell lung cancer, small cell bladder cancer and some types of gynaecological cancer. (macmillan.org.uk)
  • You will be given carboplatin and etoposide in the chemotherapy day unit or during a short stay in hospital. (macmillan.org.uk)
  • Carboplatin and etoposide chemotherapy can be given in different ways. (macmillan.org.uk)
  • Etoposide is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. (chemocare.com)
  • RATIONALE: Drugs used in chemotherapy, such as etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. (clinicaltrials.gov)
  • RATIONALE: Drugs used in chemotherapy, such as cisplatin and etoposide, work in different ways to stop tumor cells from dividing so they stop growing or die. (bioportfolio.com)
  • Chemotherapy: Patients receive cisplatin IV over 30-60 minutes on day 1 and etoposide IV over 60 minutes on days 1-3. (bioportfolio.com)
  • To compare the effects of irinotecan hydrochloride with cisplatin to the "standard" regimen etoposide plus cisplatin on overall survival, in chemotherapy-naive patients with newly diagnose. (bioportfolio.com)
  • Cancer Chemotherapy Update: Bevacizumab, Etoposide, and Cisplatin Regimen for Refractory Brain Metastases. (bioportfolio.com)
  • This study describes the prevalence of chemotherapy-induced nausea and vomiting (CINV) in pediatric patients receiving etoposide plus ifosfamide over 5 days, a common pediatric regimen. (springer.com)
  • English-speaking, non-chemotherapy-naïve patients aged 4 to 18 years about to receive etoposide 100 mg/m 2 /day plus ifosfamide 1800 mg/m 2 /day over 5 days participated. (springer.com)
  • We report a case of a 21-year-old African-American man diagnosed with relapsed non-seminomatous germ cell tumor who received high-dose chemotherapy with carboplatin and etoposide following TIGER trial arm B off-protocol. (pubmedcentralcanada.ca)
  • Delayed rhabdomyolysis after high-dose chemotherapy with paclitaxel, ifosfamide, carboplatin, and etoposide regimen has not been previously reported and needs to be considered for preventive strategy and prompt diagnosis and treatment to avoid renal complications. (pubmedcentralcanada.ca)
  • For patients who are appropriate for chemotherapy by staging, a cisplatin-based regimen such as cisplatin, bleomycin, and etoposide (BEP) is commonly used [ 1 ]. (pubmedcentralcanada.ca)
  • The TIGER trial used the paclitaxel, ifosfamide, carboplatin, and etoposide (TI-CE) regimen for the HDCT arm: paclitaxel and ifosfamide (TI) as initial salvage chemotherapy along with autologous stem cell collection with granulocyte-colony stimulating factor (GCSF) support followed by carboplatin and etoposide (CE) [ 3 ]. (pubmedcentralcanada.ca)
  • Etoposide is a prescription medicine used in combination with other chemotherapy drugs to treat certain types of cancer. (emedtv.com)
  • A phase II trial of pre-irradiation chemotherapy with BCNU, cisplatin and oral etoposide combined with radiation therapy in the treatment of glioblastoma (GBM) No significant improvement in survival rate with this pre-irradiation chemotherapy. (virtualtrials.com)
  • Paclitaxel and etoposide are two chemotherapy agents with broad cytotoxic activity and different mechanisms of action and resistance. (aacrjournals.org)
  • To assess the toxicity, tumor response rate, and effect on quality of life of daily low-dose etoposide administered for 7 consecutive days every other week in patients with AIDS-related Kaposi's sarcoma that has relapsed or progressed after systemic chemotherapy. (clinicalconnection.com)
  • tell your doctor and pharmacist if you are allergic to etoposide, etoposide phosphate (Etopophos), any other medications, or any of the ingredients in etoposide or etoposide phosphate injection. (medlineplus.gov)
  • Etoposide(Etopophos) generic Aside (100 mg) is an anti-cancer agent, prescribed for lung cancer and testicular cancer. (medindia.net)
  • Etopophos (etoposide phosphate) 113.6 mg is equivalent to etoposide 100 mg. (eviq.org.au)
  • Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. (adooq.com)
  • Etoposide is in the topoisomerase inhibitor family of medication. (wikipedia.org)
  • Etoposide works by blocking the action of an enzyme in cells called topoisomerase, which is necessary for cell replication and tumor growth. (oncolink.org)
  • Etoposide exerts its cytotoxic effect by interfering with the scission-reunion reaction of the enzyme topoisomerase II. (fresenius-kabi.com)
  • Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. (mdibl.org)
  • Osheroff,N. (1989) Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide. (scirp.org)
  • Etoposide interferes with DNA synthesis by inhibiting the enzyme topoisomerase-II. (tcichemicals.com)
  • Etoposide works by blocking the action of a certain enzyme known as topoisomerase II. (emedtv.com)
  • By blocking topoisomerase II, etoposide prevents it from relaxing DNA and causing the DNA strands to break. (emedtv.com)
  • Collectively, the present data indicate that induction of apoptosis by etoposide and related inhibitors of topoisomerase II is mediated through a cell death pathway that does not require SAPK-dependent recruitment of AP1. (aspetjournals.org)
  • Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. (acs.org)
  • Myeloperoxidase is expressed exclusively in granulocytes and immature myeloid cells and transforms the topoisomerase II (TOP2) poisons etoposide and mitoxantrone to chemical forms that have altered DNA damaging properties. (aspetjournals.org)
  • We have investigated the possibility of overcoming the resistance of human brain tumour cells (HBT20) to etoposide by transferring the normal human topoisomerase IIα (H-topo II) gene into these cells. (biochemj.org)
  • The side effects of etoposide and their severity depend on how much of the drug is given. (chemocare.com)
  • What are the possible side effects of etoposide? (cigna.com)
  • There are a number of things you can do to manage the side effects of etoposide. (oncolink.org)
  • Some of the common side effects of etoposide include nausea, vomiting, hairloss, and low counts of certain blood cells. (rxwiki.com)
  • It is used in form of its salt etoposide phosphate. (wikipedia.org)
  • This page contains brief information about etoposide phosphate and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials. (cancer.gov)
  • Etoposide phosphate is also being studied in the treatment of other types of cancer . (cancer.gov)
  • Find Clinical Trials for Etoposide Phosphate - Check for trials from NCI's list of cancer clinical trials now accepting patients. (cancer.gov)
  • etoposide phosphate is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
  • Washington Manual , www.unboundmedicine.com/washingtonmanual/view/Davis-Drug-Guide/109245/all/etoposide_phosphate. (unboundmedicine.com)
  • Etoposide is given by intravenous (IV, into a vein) infusion. (oncolink.org)
  • Determine the response rate in young patients with relapsing and/or refractory ependymoma treated with a rapid schedule of intravenous etoposide. (clinicaltrials.gov)
  • Starting from day 30, nine animals were treated with four weekly intravenous injections of etoposide oleate (6 mg/kg) associated with LDE, and nine control animals were treated with saline solution injections. (dovepress.com)
  • These include genes that may play a role in cancer (AGPAT2, IL1B, and WNT5B) and genes not yet known to be associated with sensitivity to etoposide. (nih.gov)
  • We also found that this dual inhibition of MDM2 and XIAP by transfection of MDM2 siRNA resulted in the LA1-55N cells having enhanced sensitivity to etoposide, but not doxorubicin, as the latter has a role in upregulating XIAP expression. (aacrjournals.org)
  • Following a 2 h dexamethasone treatment, H-topo II mRNA expression, protein production, etoposide-induced DNA-protein complex formation and sensitivity to etoposide were increased in HBT20-hTOP2MAM cells compared with control HBT20-MAM cells and with HBT20-hTOP2MAM cells not treated with dexamethasone. (biochemj.org)
  • In the case of etoposide there are no specific foods that you must exclude from your diet when receiving Toposar. (rxwiki.com)
  • The analysis identified 63 genetic variants that contribute to etoposide-induced toxicity through their effect on gene expression. (nih.gov)
  • Monitor etoposide trough levels and determine whether etoposide concentrations correlate with age, response, and toxicity. (knowcancer.com)
  • In previous studies, treatment of refractory cancer patients with etoposide associated with LDE had been shown devoid of toxicity. (dovepress.com)
  • The combination of cisplatin and etoposide with or without radiotherapy is effective for advanced thymoma, and has an acceptable toxicity. (nih.gov)
  • In all arms, treatment with cisplatin and etoposide repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. (centerwatch.com)
  • OBJECTIVES: I. Determine the maximum tolerated dose, dose limiting toxicity, and safety of nitrocamptothecin when administered with etoposide in patients with advanced solid tumors. (clinicalconnection.com)
  • A multi-center, open label phase I study with escalating doses of vorinostat in combination with etoposide was conducted to establish the safety of the combination in pediatric patients with refractory solid tumors to determine the maximum tolerated dose (MTD), dose limiting toxicity (DLT) and recommended phase II dose (RP2D) of this regimen. (aacrjournals.org)
  • The investigators concluded: "The addition of bevacizumab to cisplatin and etoposide in the first-line treatment of [extensive-disease small cell lung cancer] had an acceptable toxicity profile and led to a statistically significant improvement in progression-free survival, which, however, did not translate into a statistically significant increase in [overall survival]. (ascopost.com)
  • In conclusion, toxicity and antitumor activity of the paclitaxel/etoposide combination may be sequence dependent. (aacrjournals.org)
  • Nicholas, C. and Sim, S. (2012) Etoposide-induced apoptosis results in chromosome breaks within the AF 9 gene: Its implication in chromosome rearrangement in leukaemia. (scirp.org)
  • In this study we demonstrate that in neuroblastoma cells, inhibition of overexpressed MDM2 by siRNA leads to a downregulation of XIAP protein expression, resulting in an enhanced sensitivity to apoptosis triggered by the chemotherapeutic drug etoposide. (aacrjournals.org)
  • EBV-positive and EBV-negative BJA-B B cell lymphoma cell lines were used to compare the expression of selected apoptosis-regulating Bcl-2 and caspase proteins in EBV-related apoptosis resistance, after 8 hr or 18-24 hr etoposide treatment (80 microM). (unboundmedicine.com)
  • Etoposide induced cleavage of caspase-9 in both cell lines, with the EBV-positive cells having proportionally less cleavage product, in agreement with their lower levels of apoptosis. (unboundmedicine.com)
  • The results indicate that apoptosis resistance in EBV-infected B cell lymphomas is promoted by an inactive caspase-3 pathway and elevated expression of Bcl-2 that is not altered by etoposide drug treatment. (unboundmedicine.com)
  • These findings additionally suggest that activation of the SAPK represents a consequence, rather than an underlying cause, of etoposide-induced apoptosis in myeloid leukemia cells. (aspetjournals.org)
  • Etoposide induces apoptosis in U-937 GTB within 4 h. (diva-portal.org)
  • Take etoposide at around the same time(s) every day. (medlineplus.gov)
  • Take etoposide exactly as directed. (medlineplus.gov)
  • Etoposide is given as a drip over an hour, but you can also take etoposide as capsules. (macmillan.org.uk)
  • To make sure you can safely take etoposide, tell your doctor if you have kidney disease. (cigna.com)
  • Etoposide injection is used in combination with other medications to treat cancer of the testicles that has not improved or that has worsened after treatment with other medications or radiation therapy. (medlineplus.gov)
  • Etoposide injection comes as a comes as a solution (liquid) or as a powder to be mixed with liquid to be slowly injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
  • Etoposide injection is also sometimes used to treat Hodgkin's lymphoma (Hodgkin's disease), non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection), and certain types of leukemia (cancer of the white blood cells), including acute myeloid leukemia (AML, ANLL) and acute lymphoblastic leukemia (ALL) in children. (medlineplus.gov)
  • You should not become pregnant or breast-feed while you are receiving etoposide injection. (medlineplus.gov)
  • Etoposide injection may cause side effects. (medlineplus.gov)
  • Call your doctor for instructions if you miss an appointment for your etoposide injection. (cigna.com)
  • FYTOSID is available as 5 ml injection containing 100 mg of Etoposide. (fresenius-kabi.com)
  • Etoposide injection is to be given intravenously (into the vein). (mims.com)
  • If an overdose of etoposide injection is discovered while the dose is being given, the infusion will be stopped. (emedtv.com)
  • Etoposide injection [package insert]. (emedtv.com)
  • The clinical pharmacokinetics of etoposide were studied in eight pediatric patients with refractory solid tumors. (aacrjournals.org)
  • The average pharmacokinetic values derived from these eight pediatric patients with solid tumors did not differ significantly from those previously reported in children with leukemia administered similar dosages and in adults given radioactively labeled etoposide. (aacrjournals.org)
  • PATIENTS: Fifty-six of fifty-eight entered patients with measurable and progressive recurrent germ cell tumors of testicular (46 patients), ovarian (1 patient), and extragonadal (9 patients) origin were evaluable for response after not being cured with cisplatin, vinblastine, and etoposide regimens. (uni-bonn.de)
  • This study evaluates the use of carfilzomib in combination with cyclophosphamide and etoposide for children with relapsed/refractory solid tumors or leukemia. (archildrens.org)
  • The medications cyclophosphamide and etoposide are standard drugs often used together for the treatment of cancer in children with solid tumors or leukemia. (archildrens.org)
  • Abstract B81: Phase I/II trial of vorinostat in combination with etoposide in pediatric patients with relapsed/refractory solid tumors. (aacrjournals.org)
  • Conclusion: Vorinostat followed in combination with etoposide was found to be safe and well tolerated in children with refractory solid tumors. (aacrjournals.org)
  • This partially randomized phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. (yalecancercenter.org)
  • This phase I trial is studying the side effects and best dose of oxaliplatin and etoposide in treating young patients with recurrent or refractory solid tumors or lymphomas. (druglib.com)
  • PRIMARY OBJECTIVES: I. Determine the maximum tolerated dose of oxaliplatin and etoposide in pediatric patients with recurrent or refractory solid tumors or lymphoma. (druglib.com)
  • The research concluded that carboplatin-etoposide combination therapy was associated with better outcomes and safety profile than topotecan in patients with srSCLC. (physiciansweekly.com)
  • Etoposide is in a class of medications known as podophyllotoxin derivatives. (medlineplus.gov)
  • Etoposide is a semisynthetic derivative of podophyllotoxin from the rhizome of the wild mandrake (Podophyllum peltatum). (wikipedia.org)
  • Etoposide (VP 16) is a semisynthetic antitumor alkaloid which is synthesized form podophyllotoxin [ P1771 ] , a toxin found in the American Mayapple. (tcichemicals.com)
  • Etoposide belongs to a group of drugs called podophyllotoxin derivatives, which slow or stop the growth of cancer cells. (rxwiki.com)
  • Etoposide, 3′-demethyletoposide and the internal standard (4′-demethylepi-podophyllotoxin-9-(4,6- 0 -propyliodone-β-D-glucopyranoside) were obtained from Nippon Kayaku Co., Ltd. (Tokyo, Japan). (aspetjournals.org)
  • Etoposide is currently synthesized from podophyllotoxin, a natural product first isolated from the Himalayan mayapple plant, Podophyllum hexandrum . (acs.org)
  • The aglycone also requires fewer steps to convert into etoposide than does podophyllotoxin. (acs.org)
  • Effect of Zinc on Spermatogenesis and Sperm Chromatin Condensation in Bleomycin, Etoposide, Cisplatin Treated Rats. (americanelements.com)
  • Co-administration of bleomycin, etoposide and cisplatin (BEP) has increased survival rate of patients with testicular cancer. (americanelements.com)
  • EORTC Group Phase II Study of Oral Etoposide for Pretreated Soft Tissue Sarcoma," Sarcoma , vol. 1, no. 2, pp. 99-101, 1997. (hindawi.com)
  • OBJECTIVES: I. Evaluate the response rate and response duration in patients with relapsed non-Hodgkin's lymphoma when treated with daily oral etoposide. (knowcancer.com)
  • Describe the toxic effects of daily oral etoposide in these patients. (knowcancer.com)
  • OUTLINE: Patients receive oral etoposide daily for 21 days. (knowcancer.com)
  • Patients receive oral nitrocamptothecin on days 1-3 and oral etoposide on days 4-5 each week. (clinicalconnection.com)
  • The purpose is to investigate the safety and efficacy of i.p. topotecan and oral etoposide as salvage treatment for patients with platinum-resistant ovarian or primary peritoneal cancer. (aacrjournals.org)
  • Patients were treated with i.p. topotecan initial dose, 1 mg/m 2 on days 1 to 5, followed by oral etoposide 100 mg on days 6 to 9 of a 28-day cycle for six cycles. (aacrjournals.org)
  • The combination of i.p. topotecan and oral etoposide is an active and well-tolerated regimen in platinum-resistant ovarian carcinoma. (aacrjournals.org)
  • (3) demonstrated that oral etoposide (50 mg/m 2 /day) has antitumor activity in both platinum-sensitive and -resistant patients. (aacrjournals.org)
  • Additional studies are investigating the use of oral etoposide in combination with other agents in this patient population. (aacrjournals.org)
  • Patients receive low-dose oral etoposide on days 1 through 7 of every 2-week cycle. (clinicalconnection.com)
  • Oral UFT, etoposide and leucovorin in recurrent. (ugent.be)
  • In a phase I study of weekly administration of cisplatin combined with oral etoposide we achieved a cisplatin dose intensity of 52.5-60 mg/m2 per week in most patients. (eur.nl)
  • Patients were treated with cisplatin infused at 70 mg/m2 on days 1, 8, 15 and 29, 36, 43 in combination with oral etoposide given at 50 mg on days 1-15 and 29-43. (eur.nl)
  • Patients showing stable disease or a better response were continued on treatment with oral etoposide given at 50 mg/m2 per day on days 1-21 every 28 days for a maximum of four cycles. (eur.nl)
  • To assess the efficacy of maintenance pembrolizumab in extensive-stage small cell lung cancer (SCLC) patients, after treatment with platinum/etoposide. (bioportfolio.com)
  • The objective of this pilot study was to assess the safety and efficacy of cisplatin, etoposide, and radiotherapy for thymoma. (nih.gov)
  • This study aims to compare the efficacy of carboplatin-etoposide and topotecan as a second-line treatment in patients with sensitive relapsed small-cell lung cancer (srSCLC). (physiciansweekly.com)
  • If you become pregnant while taking etoposide, call your doctor. (medlineplus.gov)
  • Further, nifedipine significantly restored etoposide-induced loss in metabolic cell viability in INS 832/13 cells. (biomedsearch.com)
  • tell your doctor and pharmacist if you are allergic to etoposide, any other medications, or any of the ingredients in etoposide capsules. (medlineplus.gov)
  • Days two and three - you have a drip of etoposide, or etoposide capsules to take. (macmillan.org.uk)
  • The nurse or pharmacist may give you etoposide capsules to take at home. (macmillan.org.uk)
  • Store etoposide capsules in the refrigerator, do not freeze. (cigna.com)
  • Etoposide capsules should be taken on an empty stomach. (medbroadcast.com)
  • If an overdose with etoposide capsules was recent, a healthcare provider may administer activated charcoal or 'pump the stomach' to help reduce the amount of the medication absorbed into the bloodstream. (emedtv.com)
  • The combination of MEC (mitoxantrone, etoposide, and cytarabine) is a standard treatment option, commonly used for relapsed or refractory acute myeloid leukemia. (clinicaltrials.gov)
  • Mitoxantrone, Etoposide, and Cytarabine are administered intravenously on a daily basis for days 4 through 8 of the treatment. (clinicaltrials.gov)
  • Etoposide 500 mg/m2/day IV and Cytarabine 2000 mg/m2/day IV every 24 hours for 4 days. (clinicaltrials.gov)
  • Determine the 6-month progression-free survival of patients with previously untreated extensive stage small cell lung cancer treated with cisplatin, etoposide, and bevacizumab. (bioportfolio.com)
  • Dr. Kagan examined whether it is possible to reduce development of secondary cancer (acute myeloid leukemia) after treatment with the anticancer drug etoposide through vitamin C and E supplementation. (aicr.org)
  • Etoposide is a widely used anticancer drug successfully used for the treatment of many types of cancer in children and adults. (aspetjournals.org)
  • We hypothesized, therefore, that one-electron oxidation of etoposide by MPO to its phenoxyl radical is important for converting this anticancer drug to genotoxic and carcinogenic species in human CD34 + myeloid progenitor cells. (aspetjournals.org)
  • Etoposide is used to treat small cell lung cancer. (cigna.com)
  • Etoposide has demonstrated highly significant clinical activity against several human neoplasms including small cell lung cancer, testicular cancers and bladder cancer. (fresenius-kabi.com)
  • Etoposide is used together with other medicines to treat cancers of the lung (small cell lung cancer), blood, lymph gland, testes or ovary. (mims.com)
  • Here you can see the latest Carboplatin And Etoposide Plus LBH589 For Small Cell Lung Cancer articles that have been published worldwide. (bioportfolio.com)
  • We have published hundreds of Carboplatin And Etoposide Plus LBH589 For Small Cell Lung Cancer news stories on BioPortfolio along with dozens of Carboplatin And Etoposide Plus LBH589 For Small Cell Lung Cancer Clinical Trials and PubMed Articles about Carboplatin And Etoposide Plus LBH589 For Small Cell Lung Cancer for you to read. (bioportfolio.com)
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  • Platinum and etoposide with thoracic radiation followed by prophylactic cranial irradiation constitute the standard treatment for limited-stage small cell lung cancer (LS-SCLC). (bioportfolio.com)
  • This randomized phase II clinical trial studies how well cisplatin, carboplatin, and etoposide work when given together with nivolumab in treating patients with extensive stage lung cancer. (bioportfolio.com)
  • Etoposide treats testicular cancer and a certain type of lung cancer. (rxwiki.com)
  • The combination of etoposide (E) and cisplatin (P) is standard first line treatment for small cell lung cancer (SLSC). (oncolink.org)
  • In an Italian phase III trial reported in the Journal of Clinical Oncology , Marcello Tiseo, MD , of Azienda Ospedaliero-Universitaria, Parma, Italy, and colleagues found that adding first-line bevacizumab (Avastin) to cisplatin/etoposide did not prolong overall survival in patients with extensive-disease small cell lung cancer. (ascopost.com)
  • Superiority of sequential versus concurrent administration of paclitaxel with etoposide in advanced non-small cell lung cancer: comparison of two Phase II trials. (aacrjournals.org)
  • We performed two sequential Phase II trials using different sequence schedules of paclitaxel and etoposide as first-line treatment in advanced non-small cell lung cancer (NSCLC). (aacrjournals.org)
  • The amount of etoposide that you will receive and the method it is given depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. (chemocare.com)
  • This complication is age related but not related to the amount of etoposide exposure. (nih.gov)
  • The antitumor activity of single-agent etoposide in patients with relapsed ovarian cancer has been investigated in several small phase II studies. (aacrjournals.org)
  • However, single-agent etoposide is not yet approved for the treatment of patients with relapsed ovarian cancer. (aacrjournals.org)
  • Etoposide is a semisynthetic derivative of the podophyllotoxins. (aacrjournals.org)
  • The dosage schedule of FYTOSID (Etoposide) used most commonly in combination with other approved chemotherapeutic agent, is 50-100 mg/m2/day on days 1-5 to be repeated every 3-4 weeks. (fresenius-kabi.com)
  • Etoposide and ifosfamide are chemotherapeutic agents used frequently in the treatment of sarcomas and hematologic malignancies. (hindawi.com)
  • ClC-3 overexpression increased the acidity of intracellular vesicles, as assessed by acridine orange staining, and enhanced resistance to the chemotherapeutic drug etoposide by almost doubling the IC 50 in either BON or HEK293 cell lines. (aacrjournals.org)
  • Etoposide induces an irreversible blockade of cells in the premitotic phases of cell cycle leading to accumulation of cells in the late S or G2 phase. (fresenius-kabi.com)
  • Based on these findings, we conclude that etoposide induces loss in cell viability by inducing mitochondrial dysfunction, caspase-3 activation and degradation of FTase/GGTase α-subunit. (biomedsearch.com)
  • Together, our results are consistent with the idea that MPO-dependent oxidation of etoposide in human hematopoietic CD34 + cells makes these cells especially prone to the induction of etoposide-related acute myeloid leukemia. (aspetjournals.org)
  • The authors evaluated the combination of etoposide/cyclophosphamide (VP/CY) as initial, presurgical therapy for patients with osteosarcoma and found an 88% response rate for the primary tumor and any metastases. (uni-bonn.de)
  • The purpose of this study is to find out what effects, good and/or bad, treatment with a new combination of drugs, cyclophosphamide, etoposide, and carfilzomib has on cancer. (archildrens.org)
  • Etoposide is also sometimes used to treat certain types of ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed). (medlineplus.gov)
  • There is a slight risk of developing a blood cancer such as leukemia years after taking etoposide. (chemocare.com)
  • Etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. (cigna.com)
  • Using etoposide may increase your risk of developing other types of cancer, such as leukemia. (cigna.com)
  • Etoposide is used to treat cancer of the lung or testicles. (cigna.com)
  • Etoposide is used to treat people who have certain types of blood cancer including Hodgkin and non-Hodgkin lymphoma. (schoolandyouth.org)
  • Etoposide kills cancer cells by interfering with the genetic material DNA, which is necessary for their growth and reproduction. (medbroadcast.com)
  • As well as interfering with the genetic material (DNA) of cancer cells, etoposide can interfere with some of your normal cells. (medbroadcast.com)
  • Like quinine, etoposide also possesses a relatively low therapeutic index with some adverse reactions in cancer patients ( e.g. leukopenia) ( Kobayashi and Ratain, 1994 ). (aspetjournals.org)
  • Therefore, from a theoretical point of view, a drug-drug interaction might occur when quinine and etoposide are co-administered in patients with cancer who are living in malaria endemic areas such as Southeast Asia, South America, and East Africa ( i.e. 300 to 500 million new cases of malaria every year). (aspetjournals.org)
  • The therapeutic effectiveness of continuous infusion of 5-fluorouracil and cisplatin, and etoposide (FEP) for treatment of metastatic gastric cancer was examined. (spandidos-publications.com)
  • Oxaliplatin may also help etoposide work better by making cancer cells more sensitive to the drug. (druglib.com)
  • Giving oxaliplatin together with etoposide may kill more cancer cells. (druglib.com)
  • To evaluate the toxicities associated with the combination of temozolomide and capecitabine and the combination of platinum (cisplatin or carboplatin) and etoposide, respectively, in patients with advanced G3 non-small cell gastroenteropancreatic neuroendocrine carcinomas. (centerwatch.com)
  • 24 (4 Suppl 12): S12-144-S12-148) and Phase II (J Clin Oncol 1999 17: 2309) studies have shown that the combination of Paclitaxel-Cisplatin-Etoposide (TEP) was active in SCLC. (oncolink.org)
  • The specific effects of an overdose can vary, depending on a number of factors, including the etoposide dosage and whether it was used in combination with any other medications or substances. (emedtv.com)
  • Additional studies investigating topotecan in combination with etoposide are warranted. (aacrjournals.org)
  • Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance. (webmd.com)
  • PURPOSE: This phase II trial is studying how well etoposide works in treating young patients with ependymoma. (clinicaltrials.gov)
  • Systemic clearance, mean residence time, and β-phase half-life of etoposide were significantly lower in those patients who had received cisplatin prior to their Phase II etoposide trial. (aacrjournals.org)
  • This randomized phase II trial studies how well temozolomide and capecitabine work compared to standard treatment with cisplatin or carboplatin and etoposide in treating patients with neuroendocrine carcinoma of the gastrointestinal tract or pancreas that has spread to other parts of the body (metastatic) or cannot be removed by surgery. (centerwatch.com)
  • The recommended phase II dose was established at vorinostat 270 mg/m 2 and etoposide 100 mg/m 2 and will be evaluated in an ongoing phase II study in pediatric patients with sarcoma. (aacrjournals.org)
  • We therefore conducted a phase II trial of pre-irradiation BCNU, cisplatin and etoposide in patients with newly diagnosed GBM. (virtualtrials.com)
  • Your nurse will give you etoposide as a drip (infusion) over an hour. (macmillan.org.uk)
  • Day one - you have etoposide as a drip (infusion) over an hour and cisplatin as a drip (infusion). (macmillan.org.uk)
  • It is concluded that infusion of 5-fluorouracil, etoposide and cisplatin is effective and well tolerated. (spandidos-publications.com)
  • All patients received etoposide at 100 mg/m2, given as an i.v. infusion on days 1, 2, and 3. (aacrjournals.org)
  • The first 20 patients (part A) also received paclitaxel at 175 mg/m2 as a 3-h infusion on day 1, immediately prior to etoposide. (aacrjournals.org)
  • Etoposide may also be used for purposes not listed in this medication guide. (cigna.com)
  • Etoposide often causes nausea and vomiting, but it is very important that you continue to take the medication, even if you begin to feel ill. (medbroadcast.com)
  • Prior Medication: Excluded: - Prior etoposide. (clinicalconnection.com)
  • Etoposide is available as an injectable preparation or as a capsule to be taken by mouth. (medbroadcast.com)
  • The injectable form of etoposide will be stored at the hospital or clinic where you receive treatment. (medbroadcast.com)
  • Etoposide was first synthesized in 1966 and U.S. Food and Drug Administration approval was granted in 1983. (wikipedia.org)
  • This is not a complete list of etoposide drug interactions. (rxwiki.com)
  • This thesis encompasses in vitro studies of the kinetics and mode of cell death induced in the human cell line U-937 GTB, by CHS 828 and the standard antitumour drug etoposide. (diva-portal.org)
  • Many other medications may also interact with etoposide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • The recommended dose and dosing schedule of etoposide varies according to the specific condition being treated, the response to therapy, and the other medications or treatments being used. (medbroadcast.com)
  • Patients also receive cisplatin IV on day 1 or carboplatin IV and etoposide IV on days 1, 2, and 3. (centerwatch.com)
  • Patients also receive cisplatin or carboplatin and etoposide as in arm I. (centerwatch.com)
  • Patients also receive cisplatin and etoposide. (centerwatch.com)
  • In the open-label trial, 204 treatment-naive patients from 29 sites in Italy were randomized between November 2009 and October 2015 to receive cisplatin/etoposide with (n = 101) or without bevacizumab (n = 104). (ascopost.com)
  • Cell growth inhibition at increasing concentrations of etoposide for 72 h was determined by using alamarBlue assay. (nih.gov)
  • Prevention of organellar acidification, by inhibition of the vacuolar H + -ATPase, reduced etoposide resistance. (aacrjournals.org)
  • The mutual inhibition between quinine and etoposide with their major metabolic pathways ( i.e. quinine 3-hydroxylation and etoposide 3′-demethylation) was examined in vitro by human liver microsomes. (aspetjournals.org)
  • More importantly, if a mutual inhibition between quinine and etoposide in human liver microsomes would occur, it should provide further evidence for the role of CYP3A4 involvement in the metabolism of both quinine and etoposide. (aspetjournals.org)
  • The capacity of etoposide to promote double-stranded DNA degradation and cell death was unaffected by manipulations that interfere with SAPK signaling outflow through c-Jun/AP1, including: 1) pharmacological inhibition of AP1 activity by diferuloylmethane and 2) molecular ablation of normal c-Jun function by the Jun dominant-negative mutant TAM-67. (aspetjournals.org)
  • When these two medicines are taken together, your body may not process etoposide properly. (webmd.com)
  • Etoposide is sometimes given together with certain other medicines. (limamemorial.org)
  • This list does not include all medicines that may interact with Etoposide. (mims.com)
  • As with most medicines, it is possible to overdose on etoposide. (emedtv.com)
  • P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 determine the pharmacokinetics of etoposide. (webmd.com)
  • Correlate the extent of oxaliplatin and etoposide exposure with toxic effects and therapeutic effects of this regimen in these patients. (druglib.com)