A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.
The gradual destruction of a metal or alloy due to oxidation or action of a chemical agent. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)
Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.
A tough, malleable, iron-based alloy containing up to, but no more than, two percent carbon and often other metals. It is used in medicine and dentistry in implants and instrumentation.
A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A liquid that functions as a strong oxidizing agent. It has an acrid odor and is used as a disinfectant.
The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)
The routing of water to open or closed areas where it is used for agricultural purposes.
Adherent debris produced when cutting the enamel or dentin in cavity preparation. It is about 1 micron thick and its composition reflects the underlying dentin, although different quantities and qualities of smear layer can be produced by the various instrumentation techniques. Its function is presumed to be protective, as it lowers dentin permeability. However, it masks the underlying dentin and interferes with attempts to bond dental material to the dentin.
It is used as an oxidizing and bleaching agent and as a disinfectant. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Chemicals used mainly to disinfect root canals after pulpectomy and before obturation. The major ones are camphorated monochlorophenol, EDTA, formocresol, hydrogen peroxide, metacresylacetate, and sodium hypochlorite. Root canal irrigants include also rinsing solutions of distilled water, sodium chloride, etc.
Removal of minerals from bones during bone examination.
An activity distinguished primarily by an element of risk in trying to obtain a desired goal, e.g., playing a game of chance for money.
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.
A family of mainly aromatic evergreen plants in the order Laurales. The laurel family includes 2,200 species in 45 genera and from these are derived medicinal extracts, essential oils, camphor and other products.
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
The intrinsic moral worth ascribed to a living being. (Bioethics Thesaurus)
The ability to foresee what is likely to happen on the basis of past experience. It is largely a frontal lobe function.
Hydrazine substituted by one methyl group.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.
The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.
Nucleotide sequences, generated by iterative rounds of SELEX APTAMER TECHNIQUE, that bind to a target molecule specifically and with high affinity.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A plant genus of the family ROSACEAE known for the edible fruit.
Coloration of the skin.
Activities associated with the disposition of the dead. It excludes cultural practices such as funeral rites.
Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)
Characteristics or attributes of persons or things which elicit pleasurable feelings.
Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.
Apparatus, devices, or supplies intended for one-time or temporary use.
The discarding or destroying of garbage, sewage, or other waste matter or its transformation into something useful or innocuous.
Management, removal, and elimination of biologic, infectious, pathologic, and dental waste. The concept includes blood, mucus, tissue removed at surgery or autopsy, soiled surgical dressings, and other materials requiring special control and handling. Disposal may take place where the waste is generated or elsewhere.
An acute infectious disease caused by ORIENTIA TSUTSUGAMUSHI. It is limited to eastern and southeastern Asia, India, northern Australia, and the adjacent islands. Characteristics include the formation of a primary cutaneous lesion at the site of the bite of an infected mite, fever lasting about two weeks, and a maculopapular rash.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
A health professional's obligation to breach patient CONFIDENTIALITY to warn third parties of the danger of their being assaulted or of contracting a serious infection.
A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
Natural or synthetic dyes used as coloring agents in processed foods.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.

Cyclical etidronate increases bone density in the spine and hip of postmenopausal women receiving long term corticosteroid treatment. A double blind, randomised placebo controlled study. (1/313)

OBJECTIVE: To study the effect of cyclic etidronate in secondary prevention of corticosteroid induced osteoporosis. METHODS: A double blind, randomised placebo controlled study comparing cyclic etidronate and placebo during two years in 37 postmenopausal women receiving long term corticosteroid treatment, mainly for polymyalgia rheumatica (40% of the patients) and rheumatoid arthritis (30%). Bone density was measured in the lumbar spine, femoral neck, and femoral trochanter. RESULTS: After two years of treatment there was a significant difference between the groups in mean per cent change from baseline in bone density in the spine in favour of etidronate (p = 0.003). The estimated treatment difference (mean (SD)) was 9.3 (2.1)%. Etidronate increased bone density in the spine (4.9 (2.1)%, p < 0.05) whereas the placebo group lost bone (-2.4 (1.6)%). At the femoral neck there was an estimated difference of 5.3 (2.6)% between the groups (etidronate: 3.6% (1.4)%, p < 0.05, placebo: -2.4 (2.1)%). The estimated difference at the trochanter was 8.2 (3.0) (etidronate: 9.0 (1.5)%, p < 0.0001, placebo: 0.5 (2.3)%). No significant bone loss occurred in the hip in placebo treated patients. CONCLUSIONS: Cyclic etidronate is an effective treatment for postmenopausal women receiving corticosteroid treatment and is well tolerated.  (+info)

186Re-etidronate in breast cancer patients with metastatic bone pain. (2/313)

The aim of this study was to evaluate the efficacy of 186Re-1,1-hydroxyethylidene diphosphonate (etidronate) in breast cancer patients with painful bone metastases. METHODS: Thirty patients with advanced breast cancer who had metastatic bone pain were treated with 186Re-etidronate using different dosages in a noncomparative, open-label study. Twenty-four patients were evaluated for efficacy (6 patients had incomplete datasets). Dosages varied from 1295 to 2960 MBq (35 to 80 mCi). Efficacy was evaluated according to the multidimensional pain model using a paper-and-pencil diary. The diary was kept twice daily for 8-10 wk (2 wk before through 6-8 wk after 186Re-etidronate treatment). Response was determined with a strict criteria, in which pain intensity (PI), medication index (MI) and daily activities (DA) were core determinants. Response was defined as: (a) Reduced PI > or = 5% while MI and DA were at least constant; or (b) Reduced PI <25% in combination with improvement of MI or DA > or = 25%, without worsening of either factor. Duration of response should always exceed a minimum of 2 wk. RESULTS: Fifty-eight percent (n = 14) of all patients reported a response. The maximum follow-up period was 8 wk. Duration of response ranged from 2 to 8 wk (mean 4 wk). Patients (14/24) not only experienced considerable pain reduction, but in 12 patients this was also accompanied by noteworthy reduction in MI (> or = 25%). No clear dose-response relationship was found. CONCLUSION: With strict pain assessment criteria, 186Re-etidronate showed a response of 58% in the palliative treatment of metastatic bone pain originating from breast cancer.  (+info)

Combination 186Re-HEDP and cisplatin supra-additive treatment effects in prostate cancer cells. (3/313)

Radionuclide therapy has proven to be an efficacious palliative treatment for metastatic prostate cancer. Its potential therapeutic possibilities may be substantially increased by combining it with effective radiosensitizing drugs. METHODS: This study explores the radiosensitizing properties of cisplatin when combined with 186Re-labeled hydroxyethylidene diphosphonate (HEDP) in the treatment of R3327-MATLyLu prostate cancer cells in vitro. A concomitant incubation during 4 d, combining various concentrations of cisplatin (0, 0.42, 0.83 and 1.67 micromol/L) and 186Re-HEDP (0, 1.84 and 3.69 MBq/mL [0, 50 and 100 microCi/mL, respectively]) was followed by the determination of the cell numbers surviving and the replating of these cells in semisolid agar. RESULTS: The surviving fraction of clonogenic tumor cells after combination treatment clearly showed synergism when analyzed by a panel of three different published analytical methods. In addition, analysis of variance demonstrated a significant interaction between radionuclide therapy and cisplatin-based chemotherapy (P < 0.001). Treatment with 186Re-HEDP and cisplatin by sequential incubation yielded similar, but never superior results. CONCLUSION: It is concluded that radionuclide therapy in combination with cisplatin is able, in principle, to improve therapeutic success rate in metastatic prostate cancer in a more than additive way.  (+info)

Evidence for the promotion of bone mineralization by 1alpha,25-dihydroxycholecalciferol in the rat unrelated to the correction of deficiencies in serum calcium and phosphorus. (4/313)

Concurrent administration of 1alpha,25-dihydroxycholecalciferol [1alpha,25-(OH)2-CC] to intact and thyroparathyroidectomized rats treated with ethane-1-hydroxy-1,1-diphosphonate (EHDP) prevented or reversed the EHDP-induced inhibition of bone mineralization as measured by changes in epiphyseal plate width and ash content of bone. An analog, 1alpha-droxycholecalciferol, was also effective. Recovery of bone after EHDP treatment was also significantly improved by administration of 1alpha,25-(OH)2-CC as evidenced by enhanced uptake of 45Ca by epiphyseal plates and decreased plate widths. Cholecalciferol (CC), ergocalciferol, dihydrotachysterol2, 5,6-trans-CC, 25-OH-CC, 5,6-Trans-25-OH-CC, and 1alpha24R,25-(OH)3-CC also blocked EHDP-induced epiphyseal plate widening, but required high, pharmacological dose levels. 24R,25- (OH)2-CC was inactive at doses up to 10 microgram/day. Since EHDP-treated rats are not deficient in calcium or phosphate, these data suggest that 1alpha,25-dihydroxycholecalciferol promoted bone mineralization independently of effects upon the intestinal absorption of calcium and phosphate.  (+info)

Skeletal effects of constant and terminated use of sodium risedronate in ovariectomized rats. (5/313)

AIM: To study the skeletal effects of constant and terminated use of sodium risedronate (Ris) treatment in the ovariectomized (Ova) rats. METHODS: Ris 5 micrograms.kg-1, s.c., twice a wk. The proximal tibial metaphysis (PTM) were processed undecalcified for quantitive bone histomorphometry. RESULTS: (1) Placebo-treated (normal saline) Ova rats were characterized by decreased trabecular area (TA) on d 60, d 81, and d 150 compared with aging controls, and bone resorption was over formation with high bone turnover. (2) Ova rats were treated with Ris for 60, 81, and 150 d (Ris-on) increased. (TA 217%, 108%, and 101%) respectively, vs Ova rats and depressed bone turnover indices to aging control level, but bone mass did not maintain at high level in 150-d group as in the early stage. (3) Ova rats were pretreated with Ris for 60 d and then terminated (Ris-on/off), followed by sequential sacrifice of rats on 21 and 90 d. Withdrawal on 21 d showed the same results as the match-age Ris-on group. Withdrawal on 90 d still maintained cancellous bone mass at a high level vs 150 d Ris-on groups (+26%) and aging control group (+27%). CONCLUSION: Regimen of Ris 60 d on then 90 d off prevented the development of osteoporosis in Ova rats.  (+info)

Rhenium-186-labeled hydroxyethylidene diphosphonate dosimetry and dosing guidelines for the palliation of skeletal metastases from androgen-independent prostate cancer. (6/313)

Rhenium-186 (tin)-labeled hydroxyethylidene diphosphonate (186Re-labeled HEDP) was evaluated in 27 men with progressive androgen-independent prostate cancer and bone metastases. Administered activities ranged from 1251 to 4336 MBq (33.8-117.2 mCi). The primary objectives were to assess tumor targeting, normal organ dosimetry, and safety. Antitumor effects were assessed by posttherapy changes in prostate-specific antigen and, when present, palliation of pain. Whole-body kinetics, blood and kidney clearance, skeletal dose, marrow dose, and urinary excretion of the isotope were assessed. Targeting of skeletal disease was observed over the period of quantification (4-168 h). Radiation doses to whole body, bladder, and kidney were well tolerated. The dose-limiting toxicity was myelosuppression (grade III) at 4107 MBq (111 mCi) and grade II at 296 MBq (80 mCi). Probe clearance (whole body) and urinary excretion measurements were highly correlated. Of the six patients treated at the highest dosage schedules (three at 1510 MBq/m2 and three at 1665 MBq/m2), three showed a posttherapy decline in prostate-specific antigen of 50% or more. The declines were not sustained. The determination of total activity retained at 24 h, as well as an estimate of marrow dose, correlated with the amount of myelosuppression observed. These results suggest that a single 24-h measurement of retained activity would allow individualized dosing and an improved therapeutic index relative to fixed dosing schema. Repetitive dosing is required to increase palliation.  (+info)

Intermittent inhibition of dentin mineralization of rat incisors under continual infusion of 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP) using a subcutaneous mini osmotic pump. (7/313)

The inhibitory effect of the continual administration of 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP) (8 mgP/kg/day) through a mini osmotic pump on dentin mineralization was examined in relation to the diurnal rhythm of the rat and compared with that of daily injections of same amounts of HEBP known to inhibit dentin mineralization. After daily injections of HEBP, a series of alternating rows of mineralized and non-mineralized dentin islands appeared in the newly formed portion of the crown-analogue of rat incisors. A similar phenomenon occurred under the continual administration of HEBP in rats raised either under regular environmental photofraction or constant lighting conditions. The average distance between the adjacent mineralized dentin islands was 521.0 +/- 51.3 microns in the injected rats. After continual HEBP administration, this was 426.0 +/- 13.2 microns and 416.5 +/- 19.4 microns under ordinary photofraction and constant light, respectively. Although the pattern of individual mineralized dentin islands tended to become irregular in nocturnal rats, no statistical difference was noted between the two values. Rows of mineralized and non-mineralized dentin islands also appeared in the root analogue dentin. No sign of the intermittent inhibition of mineralization was recognized in mesodermal hard tissues other than dentin in the HEBP-affected animals. These data implicate the presence of intrinsic cycles in dentin mineralization at the growing end of rat incisors independent of environmental photofraction as well as the ameloblast function.  (+info)

Bone scintigraphy in renal osteodystrophy. (8/313)

Bone scintigraphy with Tc-99m HEDP was performed in 30 patients on maintenance hemodialysis, and the results of quantitative analysis were compared with those of a normal group. To permit this comparison, elevated background activity due to the absence of renal radiotracer excretion was reduced by hemodialysis to levels found in the normals. Histologic proof of renal osteodystrophy had been obtained in all patients. The incidence of radiographic abnormalities was 46%, whereas abnormal scans were found in 25 patients (83%); skeletal lesions were also more pronounced and detected earlier. However, even when the scans appeared normal, the quantitative analysis showed increased skeletal activity in all patients. The total skeletal activity proved to be a good index of the severity of renal osteodystrophy and appeared dependent on both osteomalacia and hyperparathyroidism. These findings show that bone scintigraphy is a sensitive method to detect skeletal involvement in renal osteodystrophy.  (+info)

Bisphosphonates, inhibitors of bone resorption, are increasingly being used for the treatment of osteoporosis. Studies have suggested that intermittent cyclical etidronate can significantly improve spinal bone mass1-3 6-9 and may lead to a decrease in vertebral fracture rates in postmenopausal women.1-3 As yet there is no clear evidence that cyclical etidronate can reduce hip fracture rates, although prospective studies with the required large numbers and power to answer this question have not been performed. Some studies, however, have shown that hip bone mass can be increased with cyclical etidronate although generally to a lesser degree than at the spine.3 8 9 There is also increasing evidence on the role of vitamin D and vitamin D analogues in treating osteoporosis. A French trial found that after daily combined treatment with 800 IU of vitamin D3 and 1200 mg calcium for 18 months, hip fractures were 43% lower and non-vertebral fractures were 32% lower in elderly housebound women when ...
Etidronate Disodium (Etidronate disodium) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
The goals of this study were to 1) demonstrate that the MTA rat mammary adenocarcinoma cell line is nonresponsive to treatment with the bisphosphonate risedronate and 2) compare the in vitro cellular responses of the MTA (nonresponder) and a related rat mammary adenocarcinoma cell line, MTB-01 (responder) to risedronate in order to identify factors responsible for the MTA cell lines response to bisphosphonate treatment.,To establish the MTA cell line as nonresponsive to risedronate treatment, Berlin- Druckery rats received an intracardiac injection of 105 MTA cells. Risedronate was administered daily to test animals beginning on the day of tumor cell inoculation. Control animals received MTA cells and daily saline injections. Animals were euthanized on day 14 and metastatic bone lesions were enumerated and area measurements were taken microscopically from femurs and vertebrae. There was no statistically significant difference in the size or number of metastatic foci in treated verses untreated ...
Etidronate (Disodium) : medicine prices in Pakistan at WhatPriceDrugs.com. List of Medication containing Etidronate (Disodium). Get information about generic, dosage forms, pack sizes and latest price.
TY - JOUR. T1 - Effects of combined administration of alfacalcidol and risedronate on cancellous and cortical bone mass of the tibia in glucocorticoid-treated young rats. AU - Iwamoto, Jun. AU - Seki, Azusa. AU - Takeda, Tsuyoshi. AU - Yamada, Harumoto. AU - Sato, Yoshihiro. AU - Yeh, James K.. PY - 2008/1/1. Y1 - 2008/1/1. N2 - The purpose of the present study was to examine the effects of combined administration of alfacalcidol (ALF) and risedronate (RIS) on cancellous and cortical bone mass of the tibia in glucocorticoid (GC)-treated young rats. One hundred and nine female Sprague-Dawley rats, 3 months of age, were randomly divided by the stratified weight method into eleven groups according to the following treatment schedule: baseline control, a 4-week age-matched control, and a 4-week GC administration with a 4-week concomitant administration of vehicle, ALF, RIS, or ALF+RIS, and an 8-week age-matched control and 8-week GC administration with a 4-week administration of vehicle, ALF, RIS, ...
Etidronic acid (INN) or 1-hydroxyethane 1,1-diphosphonic acid (HEDP) is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment. An etidronate is a salt of etidronic acid, abbreviated MnHEDP (M: is a cation, n: number of M maximum 4). Etidronic acid is a chelating agent and may be added to bind or, to some extent, counter the effects of substances, such as calcium, iron or other metal ions, which may be discharged as a component of grey wastewater and could conceivably contaminate groundwater supplies. As a phosphonate it has corrosion inhibiting properties on unnalloyed steel. Etidronic acid also acts to retard rancidification and oxidation of fatty acids. HEDP and its salts are added to detergents and other cleaning agents to prevent the effects of hard water. It is also used in peroxide bleaching to prevent degradation of peroxides by transition metals. Etidronic acid is listed as an ingredient of several cosmetic formulations where it is used for ...
The data to support the interchangeability of one risedronate 150 mg tablet versus two risedronate 75 mg tablets as monthly dose forms is primarily based on the similarity of in vitro dissolution and an in vivo study, which showed risedronate absorption is not dissolution rate limited. These results suggest that monthly dosing of risedronate may be accomplished by administration of either one risedronate 150 mg tablet or two risedronate 75 mg tablets. The purpose of this study is to provide additional clinical data to support the interchangeability of these 2 dose regimens ...
Pharmacologic Profile of Risedronate Like all bisphosphonates, risedronate selectively adsorbs to active bone remodeling sites, where it acts to inhibit osteoclast-mediated bone resorption. Risedronate reduces the risk of fracture by preventing bone loss.10 This action results in increased BMD at fracture-prone skeletal sites, notably the lumbar spine and hip, in postmenopausal women with osteopenia11 or osteoporosis.12,13 It has the same effect in patients initiating14 or receiving15 high-dose, longterm ( 6 months) glucocorticoid therapy (prednisone 7.5 mg/d or equivalent). Pharmacokinetic Properties The pharmacokinetic characteristics of risedronate are summarized in Table 3.8,16-19 Risedronate is absorbed rapidly after oral administration and exhibits linear pharmacokinetics over the oral single-dose range of 5 mg to 30 mg.20 The extent of risedronate absorption is comparable when the dose is taken 30 minutes before breakfast or 2 hours after the evening meal, which may permit dosing ...
Cheapest risedronate with overnight delivery, Where to purchase risedronate pharmacy, Risedronate store toronto, Risedronate goes generic
The occurrence of bone loss in Crohns disease patients is an important clinical problem for both patients with and without active disease. While therapy does exist for treatment and prevention of low BMD, evidence of its efficacy in Crohns disease patients is lacking. The current standard of therapy in Canada for the treatment of osteoporosis is etidronate, with adequate calcium and vitamin D supplementation.. The primary objective of the study is to assess the efficacy of risedronate, compared to placebo, administered once-weekly, in the treatment of low BMD of the spine and hip in patients with Crohns disease at 12 months, based on an intention-to-treat analysis. ...
Bisphosphonates are a highly effective and relatively safe class of medications for the prevention of fractures in patients with osteoporosis. The VERT trial published in 1999 was a landmark trial that demonstrated this protective effect with the daily oral bisphosphonate risedronate.. The trial enrolled post-menopausal women with either 2 or more vertebral fractures per radiography or 1 vertebral fracture with decreased lumbar spine bone mineral density. Patients were randomized to the treatment arm (risedronate 2.5mg PO daily or risedronate 5mg PO daily) to the daily PO placebo control arm. Measured outcomes included: 1) the prevalence of new vertebral fracture at 3 years follow-up, per annual imaging, 2) the prevalence of new non-vertebral fracture at 3 years follow-up, per annual imaging, and 3) change in bone mineral density, per DEXA q6 months.. 2458 patients were randomized. During the course of the study, data from other trials indicated that the 2.5mg risedronate dose was less ...
Etidronate is used in the treatment of osteoporosis.get complete information about etidronate including usage, side effects, drug interaction, expert advice along with medicines associated with etidronate at 1mg.com
Looking for Ethane-1,2-diol? Find out information about Ethane-1,2-diol. see glycol glycol , dihydric alcohol in which the two hydroxyl groups are bonded to different carbon atoms; the general formula for a glycol is n 2. Explanation of Ethane-1,2-diol
Risedronate by Sanis Health Inc: Risedronate belongs to a group of medications called bisphosphonates. It is used to treat and prevent osteoporosis for women who are past menopause and to treat and prevent osteoporosis caused by treatment with corticosteroids (e.g., prednisone) for men and women. It is also used to improve bone mineral density for men with osteoporosis, and to treat a condition called Pagets disease. The long-acting form of risedronate is used to treat osteoporosis in women who are past menopause only.
Risedronate - Get up-to-date information on Risedronate side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Risedronate
(1S)-1-(2-Chlorophenyl)ethane-1,2-diol 133082-13-0 NMR spectrum, (1S)-1-(2-Chlorophenyl)ethane-1,2-diol H-NMR spectral analysis, (1S)-1-(2-Chlorophenyl)ethane-1,2-diol C-NMR spectral analysis ect.
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The test item has a salt like character consiting of ethanolamine and etidronic acid. From a formal point of view the registered substance is readily biodegradable fulfilling the criteria for ready biodegradation. However, a closer look on the mass balance indicates that a stable metabolite may be formed. Whereas the ethanolamine is expected to degrade fast after dissociation in water, the etidronic acid part may be stable. A REACH dossier is confirming that the substance is not readily biodegradable, not bioaccumulative based on log KOW (-3.5), and has a chronic toxicity of , 0.01 mg/l and a acute toxicity of ,1 mg/l Although etidronic acid is not readily biodegradable, the substance is not classified and labelled with regard to ecotoxicological properties. Similarly also for ethanolamine (CAS: 141 -43 -5) a REACH dossier is available confirming that the substance is readily biodegradable, not bioaccumulative based on log KOW (1.32), and has a chronic toxicity of , 0.01 mg/l. ...
Risedronate by Pro Doc Limitee: Risedronate belongs to a group of medications called bisphosphonates. It is used to treat and prevent osteoporosis for women who are past menopause and to treat and prevent osteoporosis caused by treatment with corticosteroids (e.g., prednisone) for men and women. It is also used to improve bone mineral density for men with osteoporosis, and to treat a condition called Pagets disease.
The IUPHAR/BPS Guide to Pharmacology. etidronic acid ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Calcium: If taken together, decreased bioavailability of etidronate. Patient Instructions: Take on an empty stomach (2 hours before meals). Should be taken with a full glass of water on arising in the morning. Nothing other than water should be taken for at least 30 minutes. Even coffee or fruit juice markedly reduce absorption. Delaying such intake for longer than 30 minutes (1-2 hours if possible) maximizes absorption. After taking, the patient must remain upright to reduce risk of esophageal irritation. Any other medications must be taken at least 30 minutes after bisphosphonate. Supplement calcium and vitamin D intake if required.. Comments: Etidronate should not be used for treatment of osteoporosis. Newer bisphosphonates are preferred for treatment of Pagets as they are more potent and less likely to cause osteomalacia. Supplemental calcium and vitamin D are usually co-administered.. Clinical Pharmacology: Absorption 1%-5%; no metabolism; renal excretion. Half of absorbed dose is ...
Actonel belongs to a class of treatment that is known as bisphosphonates. The most important ingredient in Actonel is risedronate sodium. It can be found in differing quantities of 5mg, 30mg, 35mg, 75mg, or 150mg.. How It Works Bone is constantly being broken down by certain cells known as osteoclasts. It is then rebuilt and reformed by structures called osteoblasts. This is a naturally occurring process. However, in some instances, particularly after women go through menopause, there is a lower amount of estrogen in the body. This can cause more of the bone to be broken down by osteoclasts. This may eventually lead to certain disorders of the bone. While this is most common in women, a similar process can take place in men. Risedronate works by binding to the bone, preventing the calcium from being stripped away. This, in turn, stops the bone density from rapidly diminishing.. Uses. Actonel can be used to prevent the onset of osteoporosis in both males and females. However, it can also be ...
Approval for use in GIOP was based on an international phase 3 study in which denosumab proved more effective than the bisphosphonate risedronate for increasing BMD at the lumbar spine. In patien... more
disodium etidronate are chelating agents and sequestering agents that attach to metal ions to keep them from reacting with other compounds in a mixture, and to prevent them from precipitating out of solution as insoluble scums. ...
Because no information is available on the use of etidronate during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of etidronate by a breastfed infant is unlikely.
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BACKGROUND We conducted the present study to investigate the therapeutic effects of a combination treatment of alfacalcidol (ALF) and risedronate (RIS) on the bone mechanical properties of bone and calcium (Ca) metabolism using an ovariectomized (OVX) rat model of osteoporosis. METHODS Female Wistar rats were OVX- or sham-operated at 40 weeks of age. Twelve weeks post-surgery, rats were randomized into seven groups: 1) sham + vehicle, 2) OVX + vehicle, 3) OVX + ALF 0.025 microg/kg/day, 4) OVX + ALF 0.05 microg, 5) OVX + RIS 0.3 mg, 6) OVX + RIS 3.0 mg, 7) OVX + ALF 0.025 microg + RIS 0.3 mg. Each drug was administered orally five times a week for 12 weeks. After treatment, we evaluated the mechanical properties of the lumbar vertebra and femoral midshaft. In the lumbar vertebra, structural and material analyses were performed using micro-computed tomography (micro-CT) and microbeam X-ray diffraction (micro-XRD), respectively. Biochemical markers in serum and urine were also determined. RESULTS (1)
Greenstone LLC: Risedronate Sodium is a bisphosphonate indicated for: Treatment and prevention of postmenopausal osteoporosis (1.1) Treatment to increase bone...
We report synthesis of the first fluorescently labeled conjugates of risedronate (1), using an epoxide linker strategy enabling conjugation of 1 via its pyridyl nitrogen with the label (carboxyfluorescein). Unlike prior approaches to create fluorescent bisphosphonate probes, the new linking chemistry did not abolish the ability to inhibit protein prenylation in vitro, while significantly retaining hydroxyapatite affinity. The utility of a fluorescent 1 conjugate in visualizing osteoclast resorption in vitro was demonstrated.
Study to assess the efficacy, safety and pharmacokinetics of risedronate [risedronic acid] upon oral administration of a 35 mg delayed-release, a 50 mg delayed-release or a 35 mg immediate-release administered weekly for 13 weeks to postmenopausal women ...
Professional guide for Risedronate. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
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Hi have taken this for 3 weeks for bone protection & am wondering if its the cause of sudden onset of indigestion. Had a dreadful night last night & we were away from home with no medicine cupboard...
This application note shows the determination of phosphate, HEDP (etidronic acid) and pyrophosphate in a biocide sample using anion chromatography with conductivity detection after sequential suppression.
Visit your doctor or health care professional for regular checkups. It may be some time before you see the benefit from this medicine. Do not stop taking your medicine unless your doctor tells you to. Your doctor may order blood tests or other tests to see how you are doing.. You should make sure you get enough calcium and vitamin D, unless your doctor tells you not to. Discuss the foods you eat and the vitamins you take with your health care professional.. Some people who take this medicine have severe bone, joint, and/or muscle pain. This medicine may also increase your risk for a broken thigh bone. Tell your doctor right away if you have pain in your upper leg or groin. Tell your doctor if you have any pain that does not go away or that gets worse.. ...
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...
UNLABELLED Once-weekly alendronate 70 mg and once-weekly risedronate 35 mg are indicated for the treatment of postmenopausal osteoporosis. These two agents were compared in a 12-month head-to-head trial. Greater gains in BMD and greater reductions in markers of bone turnover were seen with alendronate compared with risedronate with similar tolerability. INTRODUCTION The nitrogen-containing bisphosphonates, alendronate and risedronate, are available in once-weekly (OW) formulations for the treatment of postmenopausal osteoporosis. A 12-month, head-to-head study was performed to compare these agents in the treatment of postmenopausal women with low BMD. MATERIALS AND METHODS A total of 1053 patients from 78 U.S. sites were randomized to OW alendronate 70 mg (N = 520) or risedronate 35 mg (N = 533), taken in the morning after fasting. Endpoints included BMD changes over 6 and 12 months at the hip trochanter, total hip, femoral neck, and lumbar spine (LS); percent of patients with predefined levels of
(1-Hydroxyethylidene)Bis-Phosphonic Acid Tetrasodium Salt 3794-83-0 NMR spectrum, (1-Hydroxyethylidene)Bis-Phosphonic Acid Tetrasodium Salt H-NMR spectral analysis, (1-Hydroxyethylidene)Bis-Phosphonic Acid Tetrasodium Salt C-NMR spectral analysis ect.
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Osteoporosis Drugs Market is expected to witness growth of international market with respect to advancements and innovations including development history, competitive analysis and regional development forecast.. The report starts with a basic Osteoporosis Drugs market overview. In this introductory section, the research report incorporates analysis of definitions, classifications, applications and industry chain structure. Besides this, the report also consists of development trends, competitive landscape analysis, and key regions development status.. The Osteoporosis Drugs market research report shed light on Foremost Regions like:. North America, Europe, China, Japan, Southeast Asia and India. Classification likes Antiresorptive Medications and Anabolic Medications. Application likes Hospital use and Clinic use. Browse Detailed TOC, Tables, Figures, Charts and Companies Mentioned in Osteoporosis Drugs Market ...
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Plaquenil is a drug used to treat Rheumatoid Arthritis and Systemic Lupus Erythematosis. Plaquenil related eye complications do not happen often, but pigment changes in the macula of the retina can occur.. Plaquenil related toxicity and pigment in the macula can cause blurred vision. If changes occur, they happen gradually over time and may not be noticed right away. Using our state of the art Cirrus HD-OCT 5000, West Michigan Eye & Laser can examine the macula and detect subtle changes before you begin to notice any vision changes. It is recommend that patients taking Plaquinil have their eyes examined at least once a year, using this technology.. Patients are at highest risk for sight-threatening complications when they are on a higher dose of medication for long periods of time.. Aredia (Pamidronate Disodium), Fosamax (Alendronic Acid), Ibandronate, Zometa (Zolendronate), Actonel (Risedronate Sodium), Bonefos (Clodronate), Didrocal (Etidronate Disodium), Olpadronate ...
0008]Daily and weekly oral dosing of bisphosphonates is known in the art See, for example, Harris, S. T. et al., Two-year efficacy and tolerability of risedronate once a week for the treatment of women with postmenopausal osteoporosis, Curr. Med. Res. Opin. 20(5): 757-64 (May 2004); Eisman, J. A. et al., Upper gastrointestinal and overall tolerability of alendronate once weekly in patients with osteoporosis: results of a randomized, double-blind, placebo-controlled study, Curr. Med. Res. Opin. 20(5): 699-705 (May 2004). Monthly oral dosing regimens have also been disclosed, however, current teachings indicate that greater than 100% of the cumulative effective dose of a bisphosphonate must be given in monthly treatment regimens in order to achieve comparable efficacy to that seen in daily or weekly dosing. For example, in U.S. Pat. Pub. 2003/0225039A1, by Bauss et al., published Dec. 4, 2003, the applicants teach that monthly oral treatment of at least 120%, especially 120% to 200%, of the ...
The optimal duration of bisphosphonate treatment for osteoporosis has not been established. The need for continued treatment should be re-evaluated periodically based on the benefits and potential risks of risedronate sodium on an individual patient basis, particularly after 5 or more years of use. The recommended dose in adults is one 35 mg tablet orally once a week. The tablet should be taken on the same day each week. Method of administration The absorption of risedronate sodium is affected by food, thus to ensure adequate absorption patients should take Risedronate 35 mg: Before breakfast: At least 30 minutes before the first food, other medicinal product or drink (other than plain water) of the day. Patients should be instructed that if a dose is missed, one Risedronate 35 mg tablet should be taken on the day that the tablet is remembered. Patients should then return to taking one tablet once a week on the day the tablet is normally taken. Two tablets should not be taken on the same day. ...
Investigators evaluated the efficacy of teriparatide vs risedronate in preventing clinical and vertebral fracture in post-menopausal women with existing vertebral fractures.
A comprehensive guide to side effects including common and rare side effects when taking Atelvia (Risedronate Sodium Delayed-Release Tablets) includes uses, warnings, and drug interactions.
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Auro-Risedronate: Risedronate belongs to a group of medications called bisphosphonates. It is used to treat and prevent osteoporosis for women who are past menopause and to treat and prevent osteoporosis caused by treatment with corticosteroids (e.g., prednisone) for men and women. It is also used to improve bone mineral density for men with osteoporosis, and to treat a condition called Pagets disease. The long-acting form of risedronate is used to treat osteoporosis in women who are past menopause only.
Expression of HEBP1 (HBP, HEBP) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
Comment - I am using doxyxycline in acne and to prevent deterioration of aortic aneurysms. One of the latter cases had rather severe OA hip that has not surfaced since she had a steroid shot some years ago. I now wonder if the doxycycline has helped her OA. One wonders if this might prove a safer alternative to NSAIDs in the elderly in responsive cases.. On another note, subchondral bone loss (bone loss under area of OA) is very common and use of Risedronate (a biphosphonate = bone builiding osteoporosis drug) prevents it. What that means I do not know…. Rheumatology 2007;46:257-264; A 2 yr longitudinal radiographic study examining the ...
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage
A panel of U.S. government health experts says a long-established bone strengthening drug should no longer be used by women because there is little evidence it works and it may actually increase the risk of cancer.
Atelvia (risedronate) is used to treat osteoporosis in women after menopause. Includes Atelvia side effects, interactions and indications.
tetrasodium etidronate (salt of etidronic acid). *etidronic acid. *propylene glycol. *PEG-4 (polyethylene glycol) ... Clearly, this is currently caustic soda (sodium hydroxide), since the ingredients list shows sodium salts of fatty acids, but a ... was tested to ensure the absence of excess alkali or free fatty acid. Production moved to Port Sunlight in the 1960s, when ...
These 20 included amiodarone and etidronic acid. FIASMAs are structurally diverse, but have common physicochemical properties. ... Functional inhibitors of acid sphingomyelinase, or FIASMA, is a large group of pharmacological compounds inhibiting the enzyme ... In contrast to FIASMAs, a screen of over 346,000 small molecules found only 20 that where direct inhibitors of acid ... Kornhuber J, Medlin A, Bleich S, Jendrossek V, Henkel A, Wiltfang J, Gulbins E (2010). "High activity of acid sphingomyelinase ...
V10BX03 Rhenium (186Re) etidronic acid. V10X Other therapeutic radiopharmaceuticals[szerkesztés]. V10XA Iodine (131I) compounds ...
In general, the most commonly prescribed are risedronic acid, alendronic acid, and pamidronic acid. Etidronic acid and other ... April 2008). "Failure to detect measles virus ribonucleic acid in bone cells from patients with Paget's disease". J. Clin. ... Zoledronic acid is given as an intravenous infusion; a single dose is effective for two years. This is recommended for most ...
The first generation of bisphosphonates included etidronic acid and clodronic acid which were introduced in the 1970s and 1980s ... is apparently by the formation of an ATP analogue or metabolite of the bisphosphonates like etidronic acid and clodronic acid. ... Minodronic acid is even more potent and has been placed on the market in Japan. Their potency is such that it is effective even ... Studies have showed that removal or replacement of the phosphonate group with a carboxylic acid causes drastic loss in potency ...
... etidronic acid V10XA01 Sodium iodide (131I) V10XA02 Iobenguane (131I) V10XA53 Tositumomab/iodine (131I) tositumomab V10XX01 ...
... etidronic acid), or polyelectrolytes (for example, polyacrylic acid, polymethacrylic acid, usually with a molecular weight ... can produce sulfuric acid, and can be involved in corrosion of concrete. Zebra mussels serve as an example of larger animals ... nucleic acids, etc.). The biofilm structure is usually complex. Bacterial fouling can occur under either aerobic (with oxygen ... These processes comprise pickling with acids and complexing agents, cleaning with high-velocity water jets ("water lancing"), ...
... is an abbreviation for: High Explosive Dual Purpose anti-tank / fragmenting warhead Etidronic acid or etidronate High ...
M05BA01 Etidronic acid M05BA02 Clodronic acid M05BA03 Pamidronic acid M05BA04 Alendronic acid M05BA05 Tiludronic acid M05BA06 ... Ibandronic acid M05BA07 Risedronic acid M05BA08 Zoledronic acid M05BB01 Etidronic acid and calcium, sequential M05BB02 ... Risedronic acid and calcium, sequential M05BB03 Alendronic acid and colecalciferol M05BB04 Risedronic acid, calcium and ... sequential M05BB06 Alendronic acid and alfacalcidol, sequential M05BB07 Risedronic acid and colecalciferol M05BB08 Zoledronic ...
... etidronic acid (INN) etifelmine (INN) etifenin (INN) etifoxine (INN) etilamfetamine (INN) etilefrine pivalate (INN) etilefrine ... etacrynic acid (INN) etafedrine (INN) etafenone (INN) etalocib (USAN) etamicastat (INN) etaminile (INN) etamiphylline (INN) ...
... can be prepared by reaction of Phosphorus trichloride with acetic acid in a tertiary amine, or by reaction of an ... Etidronic acid also acts to retard rancidification and oxidation of fatty acids. HEDP and its salts are added to detergents and ... Etidronic acid is a chelating agent and may be added to bind or, to some extent, counter the effects of substances, such as ... Etidronic acid is also included among swimming pool chemicals. It is used as a stain inhibitor to prevent metal ions coming out ...
Examples include HEDP (etidronic acid or Didronel), which is prepared from phosphorous acid and acetic anhydride: 2 H3PO3 + ( ... Most processes begin with phosphorous acid (aka phosphonic acid, H3PO3), exploiting its reactive P−H bond. Phosphonic acid can ... one of the simplest phosphonate diesters Etidronic acid (HEDP): 1-hydroxyethylidene-1,1-diphosphonic acid, used in detergents, ... 3 H2O Phosphonic acid also can be alkylated with acrylic acid derivatives to afford carboxyl functionalized phosphonic acids. ...
In general, the most commonly prescribed are risedronic acid, alendronic acid, and pamidronic acid. Etidronic acid and other ... Zoledronic acid is given as an intravenous infusion; a single dose is effective for two years. This is recommended for most ... "Failure to detect measles virus ribonucleic acid in bone cells from patients with Paget's disease". J. Clin. Endocrinol. Metab ...
Etidronic acid can be prepared by reaction of Phosphorus trichloride with acetic acid in a tertiary amine, or by reaction of an ... Etidronic acid also acts to retard rancidification and oxidation of fatty acids. HEDP and its salts are added to detergents and ... Etidronic acid is a chelating agent and may be added to bind or, to some extent, counter the effects of substances, such as ... Etidronic acid is also included among swimming pool chemicals. It is used as a stain inhibitor to prevent metal ions coming out ...
Etidronic acid. Atypical osteomalacia in an elderly patient: case report. Reactions Weekly volume 582, page8(1995)Cite this ... Etidronic acid. React. Wkly. 582, 8 (1995). https://doi.org/10.2165/00128415-199505820-00016 ...
Etidronic acid Oral tablet drug summary. Find medication information including related drug classes, side effects, patient ... Alendronic Acid: Oral solution, weekly , Alendronic Acid: Oral tablet , Alendronic Acid: Oral tablet, weekly , Ibandronate ... esophagus, stomach, or intestine problems, like acid reflux or GERD. -kidney disease. -osteomalacia. -trouble swallowing. -an ...
HEDP; (Hydroxyethylidene) diphosphonic acid; 1-Hydroxyethane-1,1-diphosphonic acid; 1-Hydroxyethylidene-1,1-diphosphonic acid; ... Biphosphonate, a salt, ester, or anion of a dimer of phosphonic acid (diphosphonic acid), inhibits bone resorption as a sodium ... Ibandronic acid. (Ibandronate). 114084-78-5. R1= -OH. R2= -C2H4N(CH3)C5H11 ... Olpadronic acid. (Olpadronate). 63132-39-8. R1= -OH. R2= -C2H4N(CH3)2 ...
EA is a tetrabasic acid (Н 4 L) containing two phosphonic and one hydroxyl group. In a preliminary study on the interaction of ... Etidronic acid and its calcium-comprising complexes in the treatment of experimental osteoporosis in estrogen-deficient rats. ... Etidronic acid and its calcium-comprising complexes in the treatment of experimental osteoporosis in estrogen-deficient rats ... ions with etidronic acid (EA), and to compare their effects on bone mineral density (BMD) in estrogen-deficient rats with ...
Effects of ethylenediaminetetraacetic, etidronic and peracetic acid irrigation on human root dentine and the smear layer ... Aim To evaluate the effects of ethylenediaminetetraacetic (EDTA), etidronic (EA) and peracetic acid (PA) when used in ... Aim To evaluate the effects of ethylenediaminetetraacetic (EDTA), etidronic (EA) and peracetic acid (PA) when used in ... Download PDF Effects of ethylenediaminetetraacetic, etidronic and peracetic acid irrigation on human root dentine and the ...
... Ingredient: Etidronic-acid Additive: E224 - Potassium metabisulphite ...
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Etidronic Acid. Etidronic Acid disodium (a derivative of Etidronic Acid) is reported as an ingredient of Didronate/Calcium ...
They also suggest that increasingly higher vagolytic doses hundreds of etidronic acid must be used civilians to counteract the ... reporting quality view of life found no statistically significant a difference develops between iron saccharate and etidronic ... They also suggest that increasingly higher vagolytic doses hundreds of etidronic acid must be used civilians to counteract the ... cal carepac belongs psychologically to the antihistamine group of drugs and contains has an antihistamine called etidronic acid ...
etidronic acid ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ... etidronic acid Search PubMed titles/abstracts etidronic acid Search UniChem for chemical match using the InChIKey ...
HEDP CAS 2809-21-4 Sodium Etidronic Acid US $0.5-3 / Kilogram ... Pharmaceutical Tianeptine Sodium Salt and Acid CAS 30123-17-2 ... Tags: Cas:9003-04-7 , Sodium Polyacrylate , Isopropanol--,acrylic Acid--,ammonium Persulfate ...
tetrasodium etidronate (salt of etidronic acid). *etidronic acid. *propylene glycol. *PEG-4 (polyethylene glycol) ... Clearly, this is currently caustic soda (sodium hydroxide), since the ingredients list shows sodium salts of fatty acids, but a ... was tested to ensure the absence of excess alkali or free fatty acid. Production moved to Port Sunlight in the 1960s, when ...
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ETIDRONIC ACID Moderate Concern: biodegradation; Some Concern: general systemic/organ effects, skin irritation/allergies/damage ... Warnings: Eye Irritant: Contains sulfamic acid, citric acid and surfactants. Avoid contact with eyes, skin and clothing. Wash ...
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Etidronic acid. -. 0.2. 0.2. 0.2. 0.2. 0.2. pH adjust to pH 3.5. -. qs. qs. qs. qs. qs. ... in particular aminocarboxylic acids), phosphonic acids (in particular aminophosphonic acids) and polyphosphoric acids (in ... Preferred radical scavengers are selected from the classes of alkanolamines, amino sugars, amino acids, esters of amino acids ... Examples of chelants suitable for use herein include EDDS (ethylenediaminedisuccinic acid), carboxylic acids ( ...
Etidronic Acid. Calcium Channel Blockers. Membrane Transport Modulators. Molecular Mechanisms of Pharmacological Action. Bone ...
Risedronic Acid. Etidronic Acid. Methyltestosterone. Testosterone. Testosterone undecanoate. Testosterone enanthate. ...
Etidronic Acid. Calcium Channel Blockers. Membrane Transport Modulators. Molecular Mechanisms of Pharmacological Action. Bone ...
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20 Etidronic acid ??. 21 Propylene glycol solvent, humectant and wetting agent. Irritating to eyes and skin and respiratory ... 20 Etidronic acid ??. (why so many questionmarks?) anyway its to prevent problems with hard water.. 21 Propylene glycol ... Citric Acid from e.g. lemon juice, pH 2.4, strong enough to remove limescale and copper tarnish yet probably one of the milder ... 4Citric Acid from e.g. lemon juice, pH 2.4, strong enough to remove limescale and copper tarnish yet probably one of the ...
V10BX03 Rhenium (186Re) etidronic acid. V10X Other therapeutic radiopharmaceuticals[szerkesztés]. V10XA Iodine (131I) compounds ...
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  • Aim To evaluate the effects of ethylenediaminetetraacetic (EDTA), etidronic (EA) and peracetic acid (PA) when used in conjunction with sodium hypochlorite (NaOCl) as root canal irrigants on calcium eluted from canals, smear layer, and root dentine demineralization after instrumentation/irrigation. (uzh.ch)
  • the chemicals you're looking for are EDTA and etidronic acid and 2 soaps off the top of my head that contain them are arko and proraso. (reddit.com)
  • Common chelating agents include ethylenediaminetetraacetic acid (EDTA) and its derivatives, etidronic acid and its derivatives, galactaric acid, sodium metasilicate and phosphate derivatives. (cosmeticsandtoiletries.com)
  • Sodium Etidronate (Didronel, EHDP, Etidronic acid) is a non-aminobisphosphonate that exhibits protein tyrosine phosphatase (PTP) inhibitory activity. (selleckchem.com)
  • The test item has a salt like character consiting of ethanolamine and etidronic acid. (europa.eu)
  • Whereas the ethanolamine is expected to degrade fast after dissociation in water, the etidronic acid part may be stable. (europa.eu)
  • One can calculate substantial quantities from published equations of the type (phosphoric acid) + (carbon dioxide) = (biomass). (acs.org)
  • Etidronic acid also acts to retard rancidification and oxidation of fatty acids. (wikipedia.org)
  • In creams and lotions, again they are used to prevent rancidity, the discoloration particularly of organic dyes, off-odors and the degradation of active ingredients, in addition to improving the shelf life and efficacy of vitamins, essential oils and fatty acids. (cosmeticsandtoiletries.com)
  • Usually, HEDP is also used together with polycarboxylic acid (superplasticizer), in which it acts as reducing agent. (wikipedia.org)
  • 2. The claim that etidronic acid, or 1-hydroxyethane-1,1-diphosphonate (HEDP), is as effective at 0.5% phosphorus as sodium tripolyphosphate at 7% implies a 14-fold effectiveness multiplier, which would be hard to document. (acs.org)
  • The invention relates to the use of short chain carboxylic acids, for color stabilization of colorations of keratin fibers, corresponding compositions and methods for the dyeing of fibers, and methods for maintaining dyed fibers. (google.com)
  • Phosphonates existing in various compounds as acids or salts are marketed in the form of concentrated solutions. (chemicalland21.com)
  • and of their salts with pharmaceutically acceptable mineral or organic acids. (google.com)
  • which method comprises the administration of therapeutically effective amounts of bisphosphonic acid derivatives of formula (I): ##STR1## in which: R1 is a hydrogen atom, a halogen atom, a hydroxyl, an. (google.com)
  • Warnings: Eye Irritant: Contains sulfamic acid, citric acid and surfactants. (ewg.org)
  • 04. Citric Acid from e.g. lemon juice, pH 2.4, strong enough to remove limescale and copper tarnish yet probably one of the milder ingredients in this concoction. (thenakedscientists.com)
  • Phosphonates derived from phosphorous (phosphonic) acid are employed in the applications of scale Inhibition, sequestration, dispersion and corrosion inhibition in addition to the main applications of agricultural chemicals such as fertilizers, pesticides, and soil conditioners. (chemicalland21.com)
  • Biphosphonate, a salt, ester, or anion of a dimer of phosphonic acid (diphosphonic acid), inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. (chemicalland21.com)
  • China supplier of Etidronic acid CAS:2809-21-4,(1-hydroxyethane-1,1-diyl)bis(phosphonic acid) factory,ethane-1-hydroxy-1,1-bisphosphonic acid manufacturer and Etidronic acid producer, send us your inquiry of 1-Hydroxyethylidene-1,1-diphosphonic Acid or request COA,MSDS,NMR of Hydroxyethanediphosphonic acid. (innopharmchem.com)
  • 3. A hair colouring or bleaching composition according to claim 1, wherein said non-ionic surfactant having an HLB of 7 or more (B) is selected from the group consisting of polyoxyethylene alkyl ethers having at least about 10 ethylene oxide units, polyethylene glycol fatty acid esters having at least about 10 ethylene oxide units and mixtures thereof. (freepatentsonline.com)
  • Etidronic acid is listed as an ingredient of several cosmetic formulations where it is used for suppressing radical formation, emulsion stabiliser and viscosity control. (wikipedia.org)
  • 1. A method of promoting bone repair in a mammal which comprises administering to a mammal in need thereof a therapeutically effective amount of disodium salt of tiludronic acid. (google.com)
  • Etidronic acid can be prepared by reaction of Phosphorus trichloride with acetic acid in a tertiary amine, or by reaction of an acetic acid/acetic anhydride mixture with phosphorous acid. (wikipedia.org)
  • We aimed to assess whether one intravenous infusion of zoledronic acid was non-inferior to daily oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis. (hku.hk)
  • Methods: This 1-year randomised, double-blind, double-dummy, non-inferiority study of 54 centres in 12 European countries, Australia, Hong Kong, Israel, and the USA, tested the effectiveness of 5 mg intravenous infusion of zoledronic acid versus 5 mg oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis. (hku.hk)
  • 833 patients were randomised 1:1 to receive zoledronic acid (n=416) or risedronate (n=417). (hku.hk)
  • The treatment subgroup consisted of those treated for more than 3 months (272 patients on zoledronic acid and 273 on risedronate), and the prevention subgroup of those treated for less than 3 months (144 patients on each drug). (hku.hk)
  • The aim of this study was to investigate the composition, stability, and biological activity of the complexes formed in solution upon interaction of calcium (Ca) ions with etidronic acid (EA), and to compare their effects on bone mineral density (BMD) in estrogen-deficient rats with osteoporosis. (springermedizin.at)
  • An aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatment of OSTEOPOROSIS. (bioportfolio.com)
  • A complex with rice proteins for a restructuring action, willow derivative to protect the hair color, and lipophilic fruit acids to protect the scalp during color application. (myhealthwarehouse.com.au)
  • the cleaning agent is generally used at a concentration of 1000~2000mg/L. Usually used in combination with polycarboxylic acid type scale inhibitors and dispersants. (innopharmchem.com)
  • Reduction of hard-tissue debris accumulation during rotary root canal instrumentation by etidronic acid in a sodium hypochlorite irrigant. (uzh.ch)
  • Although etidronic acid is not readily biodegradable, the substance is not classified and labelled with regard to ecotoxicological properties. (europa.eu)
  • Although it is photodegradable, etidronic acid is not biodegradable, and its toxicology (it and similar phosphonates have drug uses) is somewhat questionable. (acs.org)
  • This is why the new Sunlight anti-bacterial, with Lactic acid and mint, has been formulated to *kill 99.9% of germs on the sponge. (62-500.pl)
  • Etidronic acid, which is also used in some cleaning products, allows them to remain intact in water. (torontosun.com)
  • Ingredients of Bar Soaps The traditional bar soaps are made from oils, fats or their fatty acids that are reacted with inorganic water soluble bases. (anima-create.pl)