Sensitive method for detection of bacterial endotoxins and endotoxin-like substances that depends on the in vitro gelation of Limulus amebocyte lysate (LAL), prepared from the circulating blood (amebocytes) of the horseshoe crab, by the endotoxin or related compound. Used for detection of endotoxin in body fluids and parenteral pharmaceuticals.
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)
Substances capable of increasing BODY TEMPERATURE and cause FEVER and may be used for FEVER THERAPY. They may be of microbial origin, often POLYSACCHARIDES, and may contaminate distilled water.
An arthropod subclass (Xiphosura) comprising the North American (Limulus) and Asiatic (Tachypleus) genera of horseshoe crabs.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.
The unsuccessful attempt to kill oneself.
The act of killing oneself.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
A serotonin receptor subtype found widely distributed in peripheral tissues where it mediates the contractile responses of variety of tissues that contain SMOOTH MUSCLE. Selective 5-HT2A receptor antagonists include KETANSERIN. The 5-HT2A subtype is also located in BASAL GANGLIA and CEREBRAL CORTEX of the BRAIN where it mediates the effects of HALLUCINOGENS such as LSD.
A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.
An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
A psychedelic phenyl isopropylamine derivative, commonly called DOM, whose mood-altering effects and mechanism of action may be similar to those of LSD.
Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation.
Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT2 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT2 receptor subtypes.
Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms.
A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.
Study of stamps or postal markings. It usually refers to the design and commemorative aspects of the stamp.
Time period from 1801 through 1900 of the common era.
Time period from 1701 through 1800 of the common era.

Effects of experimental exposure to triethylamine on vision and the eye. (1/251)

OBJECTIVES: To determine the effect of triethylamine (TEA) on the cornea and to evaluate the cause of blurred vision. To find the lowest observed effect concentration of exposure to TEA. METHODS: Four people were exposed to TEA for 4 hours at concentrations of 40.6, 6.5, and 3.0 mg/m3. Before and after every exposure, symptoms and ocular microscopy findings were recorded. Binocular visual acuity and contrast sensitivity at 2.5% contrast were also measured. Also, before and after the 40.6 mg/m3 exposure, corneal thickness was measured and ocular dimensions were recorded by ultrasonography, endothelial cells of the cornea were analysed, and serum and lacrimal specimens were collected for the analysis of TEA. RESULTS: After exposure to 40.6 mg/m3 TEA there was a marked oedema in the corneal epithelium and subepithelial microcysts. However, corneal thickness increased only minimally because of the epithelial oedema. The lacrimal concentrations of TEA were, on average (range) 41 (18-83) times higher than the serum TEA concentrations. The vision was blurred in all subjects and visual acuity and contrast sensitivity had decreased in three of the four subjects. After exposure to TEA at 6.5 mg/m3 two subjects experienced symptoms, and contrast sensitivity had decreased in three of the four subjects. There were no symptoms or decreases in contrast sensitivity after exposure to a TEA concentration of 3.0 mg/m3. CONCLUSIONS: TEA caused a marked oedema and microcysts in corneal epithelium but only minor increases in corneal thickness. The effects may be mediated by the lacrimal fluid owing to its high TEA concentration. Four hour exposure to a TEA concentration of 3.0 mg/m3 seemed to cause no effects, whereas exposure to 6.5 mg/m3 for the same period caused blurred vision and a decrease in contrast sensitivity.  (+info)

Selective peroxisome degradation in Yarrowia lipolytica after a shift of cells from acetate/oleate/ethylamine into glucose/ammonium sulfate-containing media. (2/251)

We have shown that peroxisomes of the yeast Yarrowia lipolytica are subject to specific degradation after exposure of acetate/oleate-grown cells to glucose excess conditions. Electron microscopic analysis has revealed that the peroxisomes were degraded by uptake in the vacuole. Our results suggest that peroxisomes are taken up by macroautophagic processes, because sequestration of individual peroxisomes, which occurs typically at the beginning of microautophagy, was never observed. The observation that a peroxisomal amine oxidase activity is specifically induced by ethylamine was used for the development of a plate assay screening procedure to isolate peroxisome degradation-defective mutants.  (+info)

The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (sigma) receptor ligands involves both sigma1 and sigma2 sites. (3/251)

1. Sigma (sigma) receptor ligands were previously reported to alleviate learning and memory impairments on several pharmacological and pathological rodent models of amnesia. Such effect was demonstrated as involving the sigma1 subtype of sigma receptor. 2. In this study, we characterized the pharmacological effect mediated by sigma ligands on two lesional models of amnesia in mice: (1) the hypoxia-related learning and memory impairment model induced by repeated exposure to carbon monoxide (CO) gas; and (2) the intoxication with trimethyltin (1 mg kg(-1)). 3. The selective sigma1 ligand PRE-084 (1 mg kg(-1)) or the non-selective sigma1/sigma2 compounds DTG (0.1 mg kg(-1)), BD1008 (3 mg kg(-1)), and haloperidol (0.1 mg kg(-1)) reversed significantly the spontaneous alternation deficits observed 7 days after exposure to CO or 14 days after intoxication with trimethyltin. 4. The selective sigma1 receptor antagonist NE-100 (1 mg kg(-1)) was ineffective by itself, but blocked completely the PRE-084 effects, partially the DTG effects, and did not affect the effects induced by BD1008 or haloperidol. 5. A similar pharmacological profile was observed in the step-down type passive avoidance test performed 8 days after exposure to CO. 6. These results show that, in contrast to the previously reported amnesia models, the impairments induced after exposure to CO or intoxication with trimethyltin could be alleviated not only by sigma1 receptor agonists but also by sigma2 agonists. The particular pattern of neurodegeneration observed in these lesional models may explain these differences.  (+info)

Changes in collagenases and TGF-beta precede structural alterations in a model of chronic renal fibrosis. (4/251)

BACKGROUND: To study the role of collagenases and transforming growth factor-beta (TGF-beta) in the genesis of interstitial fibrosis, we used the model of bromoethylamine (BEA)-induced papillary necrosis, which is known to lead over a period of 1 to 12 months to interstitial fibrosis and renal insufficiency. METHODS: Rats were injected with BEA, and urine and kidney tissue (cortex and medulla) were collected after 1, 2, 3, 7, and 30 days. One kidney was perfused and fixed for morphological studies and immunostained for collagen type I, III, and IV. The other kidney was used to prepare cortex and medulla extracts for gelatinases (by fluorometric and zymographic techniques), tissue inhibitors of metalloproteinase-1 (TIMP-1), and TIMP-2 (by enzyme-linked immunosorbent assay, ELISA) and TGF-beta1 (by ELISA). RESULTS: Albuminuria and interstitial fibrosis were present in BEA rats by day 7, which continued until day 30. Immunocytochemical staining for collagen types showed that collagen III and IV increased in the interstitium by day 30, but collagen I remained unchanged. Gelatinase activity in the medulla decreased by 57% compared with control by day 2 and remained low until day 30. In the cortex, gelatinase activity remained unchanged between 0 and 7 days after BEA but decreased by 72% by day 30. TIMP-1 and TIMP-2 were decreased by 80% compared with day 0 in both the medulla (by day 1) and cortex (by day 2) and remained low up to day 30. TGF-beta1 immunoreactivity increased progressively until day 2 in the medulla (16-fold higher than control) and day 3 in the cortex (8-fold higher than control) and returned to control level by day 3 in the medulla and by day 30 in the cortex. Two days after BEA injection, the mRNA for TGF-beta1 was increased eightfold in the cortex and 12-fold in the medulla, and it remained high for up to 30 days. CONCLUSIONS: The fibrosis that follows papillary necrosis is associated with both high TGF-beta1 expression and depressed gelatinolytic activity.  (+info)

Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity. (5/251)

Approximately 4% of peripheral blood T cells in humans express a T cell receptor with markedly restricted germline gene segment usage (V gamma 2 V delta 2). Remarkably, these T cells expand 2- to 10-fold (8%-60% of all circulating T cells) during many microbial infections. We show here that these T cells recognize a family of naturally occurring primary alkylamines in a TCR-dependent manner. These antigenic alkylamines are secreted to millimolar concentrations in bacterial supernatants and are found in certain edible plants. Given the large numbers of memory V gamma 2 V delta 2 T cells in adult humans, recognition of alkylamine antigens offers the immune system a response of the magnitude of major superantigens for alpha beta T cells and may bridge the gap between innate and adaptive immunity.  (+info)

A new approach to empirical intermolecular and conformational potential energy functions. II. Applications to crystal packing, rotational barriers, and conformational analysis. (6/251)

An empirical potential energy function based on the interactions of electrons and nuclei (EPEN) has been tested on molecules other than those used for its parameterization. The results indicate that this energy function is able to predict reliably the lowest energy conformations, the potential energy differences between conformations, rotational barrier heights, and dipole moments for a series of alkanes, amines, alcohols, and carbohydrates. Crystal packing studies on n-hexane, n-octane, methylamine, methanol, and alpha-d-glucose, using this same potential, indicate that it is also reliable for calculating intermolecular interaction energies and low-energy orientations.  (+info)

Cryopreservation reduces the ability of hamster 2-cell embryos to regulate intracellular pH. (7/251)

Vitrification of hamster 2-cell embryos impairs the activity of both the Na(+)/H(+) antiporter and HCO(3)(-)/Cl(-) exchanger; the two transport proteins responsible for the regulation of intracellular pH (pHi). The activities of both the Na(+)/H(+) antiporter and HCO(3)(-)/Cl(-) exchanger were significantly reduced at 4 h following warming compared to freshly collected embryos. Normal levels of activity of both transporters were not restored until 6 h after warming. Thus, cryopreservation of cleavage stage hamster embryos has a detrimental effect on their ability to maintain intracellular ionic homeostasis. Impairment of these pHi regulatory proteins resulted in the pHi of embryos being significantly elevated from the control values of 1.2 to 7.35 for approximately 4 h after warming. In addition, an elevated pHi value significantly impaired oxidative metabolism. Therefore, the loss in developmental competence of embryos following cryopreservation may in part be explained by a reduced ability to regulate intracellular pH that results in perturbations in metabolism and disruption of energy production.  (+info)

GCD quantitation of opiates as propionyl derivatives in blood. (8/251)

We describe a method using a gas chromatograph with electron ionization detection (GCD) for the simultaneous determination of morphine, codeine, 6-monoacetylmorphine, ethylmorphine, and dihydrocodeine in blood. The method employs propionic anhydride in the presence of triethylamine to propionylate free hydroxyl groups of the opiates in blood. The quantitation is achieved by using GCD with selected ion monitoring of the two most characteristic ions for each analyte. The quantitation limit was 0.01 mg/L and the linearity was 0.01-10 mg/L for dihydrocodeine, ethylmorphine, and 6-monoacetylmorphine. For the other investigated opiates, the quantitation limit was 0.025 mg/L and linearity was 0.025-10 mg/L. The intraday relative standard deviation (RSD) varied from 7.2 to 10% at the 0.5 mg/L level, and the day-to-day RSDs varied from 7.5 to 11% at the 0.85 mg/L level.  (+info)

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Triethylamine hydrochloride with CAS 554-68-7,US $ 1 - 100 / Kilogram, 554-68-7, TRIETHYLAMMONIUM CHLORID, C6H16ClN.Source from Haihang Industry (Jinan) Co., Ltd. on Alibaba.com.
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The report generally describes ethylamine, examines its uses, production methods, patents. Ethylamine market situation is overviewed; ethylamine manufacturers
Alfa Aesar™ 2-(4-Fluorophenyl)ethylamine, 97% 25g Alfa Aesar™ 2-(4-Fluorophenyl)ethylamine, 97% Fluorophenyli to Fluorotrifluoromethylbenzo...
How is S-(-)-1(1-naphthyl)ethylamine abbreviated? S-NEA stands for S-(-)-1(1-naphthyl)ethylamine. S-NEA is defined as S-(-)-1(1-naphthyl)ethylamine rarely.
Read Polythermal study of the salting-out of triethylamine from aqueous solutions with sodium nitrate, Russian Journal of Applied Chemistry on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Guidchem offer qualified suppliers for R-(+)-1-(1-naphthyl)ethylamine (CAS NO.3886-70-2) ,Find latest products of R-(+)-1-(1-naphthyl)ethylamine manufacturers, suppliers, exporters and producers on guidechem.com.
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2-(4-bromo-2,5-dimethoxyphenyl)ethylamine: behaves as a partial agonist toward both alpha1-adrenergic & 5-HT(2) serotonergic receptors
Unless specified otherwise, MP Biomedicals products are for laboratory research use only, not for human or clinical use. For more information, please contact our customer service department ...
傳統製備聚醯亞胺是加成聚合二胺與二酸單體於高極性溶劑形成前驅物-聚醯胺酸,加熱使聚醯胺酸轉變為聚醯亞胺,其環化溫度需高於350 oC且環化時間長,此高溫製程可能會損害相關之電子元件及產生高熱應力等問題。本研究的目的即為開發新型低溫環化製程的聚醯亞胺,其環化溫度低於250 oC且具有優良機械性質、熱性質及電學性質。許多學者研究以添加酸性觸媒或鹼性觸媒來降低其環化溫度,觸媒的主要作用是促進Carboxylate ion對Amide carbonyl unit的親核性攻擊,產生Isoimide的中間物,降低聚醯胺酸變成聚醯亞胺的活化能,能有效降低環化溫度。在1966年 J. A. Kreuz 等人發現在聚醯胺酸內添加 Triethylamine 能有效增加環化速率,隨著溫度越高其環化速率越大且環化程度越高;在1966年 M. Oba 發現具有雙官能機團的觸媒才具有使聚醯胺酸在低溫完全環化的能力。在2004年 K.
(S)-(-)-1-(1-Naphthyl)ethylamine 10420-89-0 NMR spectrum, (S)-(-)-1-(1-Naphthyl)ethylamine H-NMR spectral analysis, (S)-(-)-1-(1-Naphthyl)ethylamine C-NMR spectral analysis ect.
Intracellular stain of nuclear receptor - posted in Flow Cytometry: Hi, Im trying to do intracellular staining of mouse dendritic cells. Since I only have non-conjugated antibody, I have to do indirect staining by secondary antibody conjugated with PE. Ive tried several fix and perm condition (90% MeOH, 70% EtOH, 0.1% Saponin at different time point and temperature), there is still no staining using Histone (H4) as my positive control. Ive tried also eBioscience Foxp3 stai...
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see article for more reactions. Abstract. A mild, convenient, fast, and nonreductive deiodination is reported for ortho-iodo-hydroxylated arenes using pyridine, triethylamine, and N-methylmorpholine in the presence of water. The regioselectivity is discussed.. ...
N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide (3) was synthesized by reacting 4,4,4-trifluorobutanoic acid (1) with 2-amino-4-chlorobenzonitrile (2) in the presence of triethylamine and propylphosphonic anhydride in ethyl acetate. Character-ization of the compound was done by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis.
Theanine and GABA work synergistically to relax the body and mind. Theanine and GABA form a natural stack that fights anxiety and can improve sleep.
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2-Bromoethylamine hydrobromide (BEA) causes complete papillary necrosis within 24-hr of i.v. administration. The mechanism of this effect is unknown. To characterize further the effect of BEA in transporting epithelia, the urinary bladders of toads and turtles were exposed to varying concentrations of BEA in vitro. In the toad bladder, both cyclic AMP- and vasopressin-stimulated water flow were significantly inhibited after 3 hr of exposure to BEA at a concentration as low as 2.5 X 10(-4) g/ml; after 1 and 2 hr no effect on water transport was observed. Serosal administration of BEA to both toad and turtle bladders significantly inhibited sodium transport to 54% of control at the end of 3 hr. The effect on sodium transport was seen as early as 10 min. The threshold for the effect on sodium transport occurred at a concentration less than that observed for water transport. By contrast, BEA had no effect on hydrogen ion secretion in the isolated turtle bladder over a wide range of concentrations. ...
Binary ethylenimine (BEI) is a preparation of aziridine. It can be produced by heating bromoethylamine hydrobromide or 2-aminoethyl hydrogen sulfate in the presence of sodium hydroxide (Gabriel method). It contains at least one three-membered ring which is very reactive because of the ring strain. It is used to inactivate the foot-and-mouth disease virus in vaccines for cattle, as well as other viruses and mycoplasma in blood samples. Contrary to early assumptions that ethylenimines only modified nucleic acids, it was found that trimeric ethyleimine also alters proteins in virus preparations, especially at higher pH values. The modification of the proteins affected viral particle uptake into cells. This should be taken into consideration when using BEI and other ethyleneimines as well. BEI is very hazardous since it attacks nucleic acids and proteins as described above. It can be neutralised by sodium thiosulfate; the thiosulfate is a nucleophile which opens the three-membered ring. The presence ...
TY - JOUR. T1 - Sigma-pi interactions in non-conjugated polyalkynes. T2 - A photoelectron spectroscopic study. AU - Lichtenberger, Dennis L.. AU - Subramanian, Lalitha. AU - Bunz, Uwe. AU - Vollhardt, K. Peter C.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - Through-space and through-bond interactions between π-orbitals in the molecules hepta-1,6-diyne (A), 3,3-diethylpenta-1,4-diyne (B), 4,4-diprop-2-ynylhepta-1,6-diyne (C), 2,2-di(bromomethyl)-1,3-dibromopropane (D) and 4,4-diethynylhepta-1,6-diyne (E) have been studied using gas-phase HeI photoelectron spectroscopy. The assignments of the photoelectron bands are discussed in relation to the results of extended Hückel calculations. Mixing of the π orbitals with the σ bond framework of the molecules is revealed by broadened band profiles in the π ionization region. Detailed examination of the first ionization of A suggests that one conformation is predominant under the conditions of the experiment. The terminal π orbitals are separated by too great ...
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Objectives: To determine whether blurred vision caused by exposure to triethylamine (TEA) can be detected by the measurement of contrast sensitivity. Methods: 41 cold box core makers of three foundries and 82 control workers were examined. A detailed ocular and medical history was obtained from the subjects. The contrast sensitivity of the core makers was measured on Monday and Friday of the same week both before and immediately after work and also on a third day, when air samples of TEA were collected. Contrast sensitivity and visual acuity were measured by optotype figures at full contrast, 2.5% contrast, and 0.6% contrast. The changes in contrast sensitivity were used for the analysis. The results of binocular vision and the results of the dominant eye were analysed. Urine specimens for the analysis of TEA were collected on every occasion when contrast sensitivity was measured. Results: 78% of the core makers had had symptoms of blurred vision, and31% had had trouble driving or working. The ...
Papillary necrosis can cause ureteral obstruction as sloughed papilla pass down the ureter. Analgesic abuse, liver cirrhosis, and diabetes are the most common risk factors for this condition; other kn... more
Papillary necrosis answers are found in the Diagnosaurus powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
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The report generally describes 2-(diisopropylamino)-ethylamine, examines its uses, production methods, patents. 2-(Diisopropylamino)-ethylamine market
In a 500-ml. three-necked flask equipped with a mechanical stirrer, a dropping funnel, and a reflux condenser fitted with a potassium hydroxide drying tube are placed 7.0 g. (0.069 mole) of triethylamine (Note 1) and a solution of 3.15 g. (0.075 mole) of diazomethane in 200 ml. of ether (Note 2). The flask is cooled in an ice bath, and a solution of 13.0 g. (0.052 mole) of D-camphor-10-sulfonyl chloride (Note 3) in 75 ml. of anhydrous ether is added dropwise over a period of 1 hour. Triethylamine hydrochloride slowly precipitates. The reaction mixture is stirred for an additional 30 minutes and then concentrated to ca. 150 ml. under reduced pressure (water aspirator) with continued stirring to remove the excess of diazomethane. The mixture is filtered under reduced pressure; the precipitate is washed with 50 ml. of anhydrous ether, giving 6.7 g. (94%) of triethylamine hydrochloride. The combined filtrate and washings are freed of solvent on a rotary evaporator at room temperature to give 10.7 g. ...
Mild pyelonephritis, renal papillary necrosis, and mineralization of the renal papillae in dosed male and female rats and hyperplasia of the renal pelvis epithelium, dilatation of the renal pelvis, and renal cysts in dosed female rats were observed at increased incidences compared with those in vehicle controls. A renal tubular cell carcinoma was observed in one low dose male rat, and renal tubular adenomas were observed in three high dose male rats. A carcinoma of uncertain histogenesis was observed in one low dose female rat. Carcinomas of the renal transitional epithelium were seen in two high dose female rats. When the kidneys were step-sectioned, additional tubular cell adenomas were diagnosed in four low dose and one high dose male rats and in three low dose and one high dose female rats; none was observed in vehicle controls.. Papillomas of the transitional epithelium of the urinary bladder were seen in 2/43 low dose male and 1/49 low dose female F344/N rats. The historical incidence of ...
Mild pyelonephritis, renal papillary necrosis, and mineralization of the renal papillae in dosed male and female rats and hyperplasia of the renal pelvis epithelium, dilatation of the renal pelvis, and renal cysts in dosed female rats were observed at increased incidences compared with those in vehicle controls. A renal tubular cell carcinoma was observed in one low dose male rat, and renal tubular adenomas were observed in three high dose male rats. A carcinoma of uncertain histogenesis was observed in one low dose female rat. Carcinomas of the renal transitional epithelium were seen in two high dose female rats. When the kidneys were step-sectioned, additional tubular cell adenomas were diagnosed in four low dose and one high dose male rats and in three low dose and one high dose female rats; none was observed in vehicle controls.. Papillomas of the transitional epithelium of the urinary bladder were seen in 2/43 low dose male and 1/49 low dose female F344/N rats. The historical incidence of ...
Heres what it says in the New and unusual causes of acute renal failure in dogs and cats chapter in the 2004 Vet Clinics Issue on Nephrology: Dogs are probably more susceptible to renal damage and ARF caused by NSAIDs or COX-2 inhibitors than are people because of differences in renal anatomy, distribution of COX-2 in renal tissues, and expression of COX-2 in volume-depleted states. Species with unipapillary kidneys, such as dogs, are more sensitive to NSAID-induced renal toxicity than are people, who are a multipapillary species. There are also species differences in renal medullary distribution of COX-1 and COX-2. The papillary tip has comparatively low renal oxygen tension, so it is more susceptible to injury than other parts of the kidney. Dogs exhibit one or both COX isoforms in the papillary interstitial cells, which are a rich source of prostaglandins. Interstitial cells are the first cell type to undergo renal papillary necrosis caused by NSAIDs and are proably the most susceptible ...
Aspirin may enhance the activity of coumarin anti-coagulants and oral antidiabetic preparations and sulphonamides. Aspirin diminishes the effects of anti-gout preparations such as probenecid and sulphin-pyrazone. Barbiturates and other sedatives may mask the respiratory symptoms of aspirin overdosage and have been reported to enhance its toxicity. Prolonged use of high doses may lead to anaemia, blood dyscrasias, gastro-intestinal haemorrhage, peptic ulceration, and renal papillary necrosis ...
Oracle has acquired BEA Systems, Inc., a leading provider of enterprise application infrastructure solutions. The addition of BEA is expected to accelerate innovation by bringing together two companies with a common vision of a modern service-oriented architecture (SOA) infrastructure and to further increase the value that Oracle delivers to its customers and partners. Together, Oracle and BEA provide a complementary best-in-class middleware portfolio that spans Java Application Servers, transaction processing monitors, SOA and business process management, user interaction and Web 2.0, identity management, business intelligence, enterprise content management and vertical-specific technologies.
Oracle has acquired BEA Systems, Inc., a leading provider of enterprise application infrastructure solutions. The addition of BEA is expected to accelerate innovation by bringing together two companies with a common vision of a modern service-oriented architecture (SOA) infrastructure and to further increase the value that Oracle delivers to its customers and partners. Together, Oracle and BEA provide a complementary best-in-class middleware portfolio that spans Java Application Servers, transaction processing monitors, SOA and business process management, user interaction and Web 2.0, identity management, business intelligence, enterprise content management and vertical-specific technologies.
Able to cross the blood-brain barrier, theanine has reported psychoactive properties.[28] Theanine has been studied for its potential ability to reduce mental and physical stress,[29] improve cognition,[30] and boost mood and cognitive performance in a synergistic manner with caffeine.[31][32][33][34][35][36]. A Natural Standard monograph that reviews current research on theanine reports that it is likely safe in doses of 200-250 mg up to a maximum daily dose of 1,200 mg. Though some people use theanine for these purposes, Natural Standard rates the evidence to support the usage for anxiety reduction, blood pressure control, and mood improvement as unclear or conflicting scientific evidence and the evidence for improved cognition as fair negative scientific evidence. Many of the studies of theanine were done in combination with caffeine as found in tea. While the studies found that the combination had some effect on mood, the studies found that theanine alone had little effect.[37] A review ...
Laminar premixed flames of the two smallest isomeric amines, dimethylamine and ethylamine, were investigated under one-dimensional low-pressure (40 mbar) conditions with the aim to elucidate pathways that may contribute to fuel-nitrogen conversion in the combustion of biomass. For this, identical flames of both fuels diluted with 25% Ar were studied for three different stoichiometries (Phi = 0.8, 1.0, and 1.3) using in situ molecular-beam mass spectrometry (MBMS). Quantitative mole fractions of reactants, products and numerous stable and reactive intermediates were determined by electron ionization (EI) MBMS with high mass resolution to separate overlapping features from species with different heavy elements by exact mass. Species assignment was assisted by using single-photon vacuum-ultraviolet (VUV) photoionization (PI) MBMS. The results indicate formation of a number of nitrogenated intermediates, including toxic species such as HCN, in appreciable concentrations. Such intermediate species ...
Chemicals - Other China, S Ethyl 2 Benzamido 3 Phenylpropanoate 7200 18 1 4 Nitrophenyl Ethylamine Hydrochloride 57233 86 0 A, ( S) - ethyl 2- benzamido- 3- phenylpropanoate CAS NO: 7200- 18- 2 Purity: 99% min Package: on request ( S) - 1- ( 4- Ni...
EaseChem provides information about L-Lysine, hydrobromide(1:?), L-Lysine,hydrobromide (9CI); Lysine, hydrobromide, L- (8CI), CAS No.: 24325-21-1.,L-Lysine,hydrobromide (9CI); Lysine, hydrobromide, L- (8CI)
Lodamin, the oral formulation of TNP-470, a methionine aminopeptidase 2 (MetAp2) inhibitor, was previously shown to significantly inhibit angiogenesis and suppress the progression of fast growing murine tumors. Lodamins unique structure as a polymer micelle composed of poly(ethylene-glycol)-poly(lactic)acid (PEG-PLA) conjugate of TNP-470 is pharmacologically advantageous over the non-conjugated form. It shows better stability, oral availability, solubility in water and importantly, has an improved safety profile (Benny O. Folkman J et al, Nat Biotech, 2008). We now report the successful large scale synthesis of Lodamin, yielding pure and active product composed of mPEG-PLA-TNP-470 conjugate without residual free drug as confirmed by NMR and LC-MS/MS. The safety profile of Lodamin was studied in an acute high dose rat study (4 fold higher than therapeutic dose). Lodamin was administered at 10mg/kg or 60mg/kg via oral gavage while control rats were given vehicle only. After 7 days of daily ...
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Bea Technologies is an ISO 9001 certified manufacturer of filter cartridges, equipment and systems. Our filters are used with confidence and satisfaction by ...
We have attempted to simplify the procedure for coupling various ligands to distal ends of liposome-grafted polyethylene glycol (PEG) chains and to make it applicable for single-step binding of a large variety of a primary amino group-containing substances, including proteins and small molecules. With this in mind, we have introduced a new amphiphilic PEG derivative, p-nitrophenylcarbonyl-PEG-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (pNP-PEG-DOPE), synthesized by reaction of DOPE with excess of bis(p-nitrophenylcarbonyl)-PEG in a chloroform/triethylamine mixture. pNP-PEG-DOPE readily incorporates into liposomes via its PE residue, and easily binds primary amino group-containing ligands via its water-exposed pNP groups, forming stable and non-toxic urethane (carbamate) bonds. The reaction between the pNP group and the ligand amino group proceeds easily and quantitatively at pH around 8.0, and remaining free pNP groups are promptly eliminated by spontaneous hydrolysis. Therefore, pNP-PEG-DOPE could
Negative mode (applies a negative voltage to the source): acidic compounds as the acid loses a proton (general buffers: ammonium, triethylamine ...
Reforming is effected with a combination of a primary supported noble-metal catalyst and a catalyst containing one or more medium pore non-zeolite molecular sieves (MP-NZMS). The latter reforming and dehydrocyclization comprise a Group VIII metal and at least one bound MP-NZMS characterized in the calcined form by an adsorption of isobutane of at least 2 percent by weight at a partial pressure of 500 torr and a temperature of 20 C. and characterized by an adsorption of triethylamine less than about 5 percent by weight at a partial pressure of 2.6 torr and a temperature of 22 C., The MP-NZMS catalyst binder preferably is alumina and/or silica, and the Group VIII metal preferably is platinum.
Two 3d-4f hetero-metal pentanuclear complexes with the formula {[CrIII2LnIII3L10(OH)6(H2O)2]Et3NH} [Ln=Tb (1), Dy (2); HL=pivalic acid, Et3N=triethylamine] have been produced. The metal core of each cluster is made up of a trigonal bipyramid with three LnIII ions (plane) and two CrIII ions (above and below) held together by six μ3-OH bridges. Also reported with this series is the diamagnetic CrIII-YIII analogue (3). Fortunately, we successfully prepared AlIII-LnIII analogues with the formula {[AlIII2LnIII3L10(OH)6(H2O)2]Et3NH⋅H2O} [Ln=Tb (4), Dy (5)], containing diamagnetic AlIII ions, which can be used to evaluate the CrIII-LnIII magnetic nature through a diamagnetic substitution method ...
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The cold section of an ethylene plant is responsible for cooling and purifying the product-grade ethylene, propylene and other bi-products from the cracking furnaces. Cracked gas is cooled in transfer-line exchangers which produce steam from the effluent gas energy. Gas is further cooled with water in the quench column, scrubbed and dried before being compressed in the cracked gas compressor and fed to the cold box.. ...
Newsgroups: bionet.molbio.methds-reagnts,bionet.molbio.proteins,bionet.genera l,sci.bio.technology,bionet.cellbiol,bionet.microbiology THE NIGHT BEFORE DEFENSE (or A Visit From Citrate) Twas the night before Defense, when all through the lab Not a gel box was shaking, with stain or with MAb; The columns were hung in the cold room with care, In hopes that my protein, I soon could prepare; The post-docs were nestled all smug in their beds, While extracts of barley muddled their heads; With the tech in the suburbs and PI the same, I had just settled down to another video game. When out of the fridge there arose such a clatter I sprang from the terminal to see what was the matter. Away to the cold box, I flew like a flash But the stench was oerpowering and I threw up beef hash. The mould on the dampest of walls which were cold Had the softness of kittens only seven weeks old; When what to my view, a thing I despise But a half eaten sandwich and four tiny mice; With a little old scientist, so lively ...
THE NIGHT BEFORE DEFENCE (or A Visit From Citrate) Twas the night before defence, when all through the lab Not a gel box was shaking, with stain or with MAb; The columns were hung in the cold room with care, In hopes that my protein, I soon could prepare; The post-docs were nestled all smug in their beds, While extracts of barley muddled their heads; With the tech in the suburbs and PI the same, I had just settled down to another video game. When out of the fridge there arose such a clatter I sprang from the terminal to see what was the matter. Away to the cold box, I flew like a flash But the stench was oerpowering and I threw up beef hash. The mould on the dampest of walls which were cold Had the softness of kittens only seven weeks old; When what to my view, a thing I despise But a half eaten sandwich and four tiny mice; With a little old scientist, so lively and galling, I knew at a glance was Linus Pauling. More vapid than undergrads, his charges they came, And he whistled, and shouted, ...
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A risk factor is something that increases your chances of developing cancer. Some risk factors such as family history or genetics cannot be changed. Fortun
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Etherchain is an Explorer for the Ethereum blockchain. It allows you to view your account balance, look up transactions and explore smart contracts.
Branch: refs/heads/master Home: https://github.com/phpmyadmin/phpmyadmin Commit: a2ef06b57857a1f18942299beae30539bea589e7 https://github.com/phpmyadmin/phpmyadmin/commit/a2ef06b57857a1f18942299beae30539bea589e7 Author: Aputsiaĸ Niels Janussen ,[email protected], Date: 2015-09-16 (Wed, 16 Sep 2015 ...
Firebolt raises $127M more for its new approach to cheaper and more efficient big data analyticsJune 24, 20210. Snowflake changed the conversation for many companies when it comes to the potentials of data ... ...
6024-81-3 - ZQUFCGVGOOZGBJ-JBWJDFQYSA-N - beta-Erythroidine, tetrahydro-, hydrobromide - Similar structures search, synonyms, formulas, resource links, and other chemical information.
AURUM Pharmatech offers,870553-46-1,3-(2-Amino-ethyl)-4-bromo-phenol hydrobromide,Br.NCCC1C(Br)=CC=C(O)C=1,C8H10NOBr.HBr,MFCD22689208,3-(2-Amino-ethyl)-4-bromo-phenol hydrobromidefor your research needs
Researchers at the University of Leeds have made a new synthetic anti-cancer molecule that targets two key mechanisms in the spread of malignant tumours through the body.
vc_row][vc_column][layerslider_vc][/vc_column][/vc_row][vc_row][vc_column][vc_column_text] [sidebar name=ad-upper-home] [/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_raw_html] JTNDaDElMjBzdHlsZSUzRCUyMmNvbG9yJTNBJTIzRjIwMDlCJTNCZm9udC1zaXplJTNBNTBweCUzQm1hcmdpbiUzQTBweCUzQmJvcmRlci10b3AlM0ExMHB4JTNCYm9yZGVyLWNvbG9yJTNBJTIzRjIwMDlCJTNCJTIyJTNFVEhFJTIwU1RZTElaRUQlMjBMSUZFJTNDJTJGaDElM0U=. [/vc_raw_html][/vc_column][/vc_row][vc_row][vc_column width=1/4″][vc_raw_html] JTNDcCUyMGNsYXNzJTNEJTIyY2F0LXRhZ3MlMjB0YWcxJTIyJTNFQmVhdXR5JTIwJTI2YW1wJTNCJTIwU3R5bGUlM0MlMkZwJTNF. [/vc_raw_html][vc_basic_grid max_items=1″ element_width=12″ gap=10″ grid_id=vc_gid:1445847745371-c4bea50a-dc6c-0″ taxonomies=2715″][/vc_column][vc_column width=1/4″][vc_raw_html] JTNDcCUyMGNsYXNzJTNEJTIyY2F0LXRhZ3MlMjB0YWcyJTIyJTNFRm9vZCUyMCUyNmFtcCUzQiUyMFJlY2lwZXMlM0MlMkZwJTNF. [/vc_raw_html][vc_basic_grid max_items=1″ element_width=12″ gap=10″ ...
A series of mistakes over 3.7 billion years has left us with a spectacular array of protein structures and functions, which are responsible for life itself, writes Bea Perks
So far Im 0 for 3 and no mach possible. I was determined to salvage JWW for pride alone. She held her start. I threw in 4, count them 4 front crosses, 1 blind cross after a tunnel, got 15 feet lateral on the weaves, and layered the final 4 jump finish run out. Bea was going so fast she could not stop and jumped the ring gate after the last jump. She jumped back in whe n I called her, and they moved the ring gates back for the rest of the dogs. We got 2nd by 3/10 of a second with a 24.84. Only the 1st place dog and 1 other NQ dog broke 25 seconds ...
On Mon, Dec 31, 2012 at 08:21:07AM +1100, Liz wrote: , , http://www.ganfyd.org/index.php?title=Estimated_glomerular_filtration_rate (MDRD) , That equation involves race, and has a correction factor for blacks GNUmed is technically prepared for that but does not yet allow structured input of race. , I suspect that a series of equations will be required. Indeed. For the time being I have implemented Schwartz, if age , 13 MDRD, if 12 , age , 85 GNUmed asks its calculator for eGFR on patient X which will return eGFR by the age-appropriate formula. Karsten -- GPG key ID E4071346 @ gpg-keyserver.de E167 67FD A291 2BEA 73BD 4537 78B9 A9F9 E407 1346 ...
At this point I woke up sobbing...I cried all day and continue to cry as I type this. It was so real, so vivid! Is it possible that God gives us the opportunity to see loved ones in our dreams to calm our hearts? We of course went to visit Bea today and leave her a little flower and a pin wheel for AJ. Til we meet again in our dreams.... ...
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May 2010). "Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors". Bioorganic & Medicinal Chemistry ...
Ward, Kyle (1935). "The Chlorinated Ethylamines - A New Type of Vesicant". J. Am. Chem. Soc. 57 (5): 914-916. doi:10.1021/ ...
Part 2. 4-Thio-substituted [2-(2,5-dimethoxyphenyl)ethyl]amines (=2,5-dimethoxybenzeneethanamines)". Helvetica Chimica Acta. 86 ...
Annual production of three ethylamines was estimated in 2000 to be 80,000,000 kg. It is used in the production of corrosion ...
He prepared three ethylamines and tetraethylammonium compounds and established their structural relationship to ammonia. After ...
In 1964 the plant began producing Methyl(ethyl)amines which are necessary for rocket fuel. In 1993, the industrial association ...
For example, methyl and ethyl amines are gases under standard conditions, whereas the corresponding methyl and ethyl alcohols ...
... and amines into ethylamines. Short chain monohalocarbons in general are potentially dangerous alkylating agents. Bromides are ...
... of the main reasons for these differential effects is the obviously increased polarity of the hydroxy-substituted phenyl ethyl amines ...
"Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors". Bioorganic & Medicinal Chemistry Letters. 20 (9 ...
... and ethyl amines. Ethanol is considered a universal solvent, as its molecular structure allows for the dissolving of both polar ...
... is an organic nitrogenous compoond involved in local immune responses as well as regulatin pheesiological function in the gut an actin as a neurotransmitter.[2]. ...
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May 2010). "Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors". Bioorganic & Medicinal Chemistry ...
Ward, Kyle (1935). "The Chlorinated Ethylamines - A New Type of Vesicant". J. Am. Chem. Soc. 57 (5): 914-916. doi:10.1021/ ...
Ethylamines. When heated to 150-220 °C over a silica- or alumina-supported nickel catalyst, ethanol and ammonia react to ... The ethylamines find use in the synthesis of pharmaceuticals, agricultural chemicals, and surfactants. ...
Table 10 Ethylamines Market Size, By Region, 2012 2019 ($Million) Table 11 Ethylamines Market Size, By Region, 2012 2019 ( 000 ... 7.3 Ethylamines 7.4 Propylamines 7.5 Butylamines 7.6 Cyclohexylamines 8 Alkylamines Market, By Application (Page No. - 48). 8.1 ... HOME › Top Market Reports › Alkylamines Market by Types (Methylamines, Ethylamines, Propylamines, Butylamines, & ... The amines market is segmented on the basis of types Methylamines, Higher Alkylamines (ethylamines, propylamines, butylamines ...
BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).. Clarke B, Demont E, Dingwall C, Dunsdon R, ... BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells. ... BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character. ...
Ethylamines [D02.092.471]. *Phenethylamines [D02.092.471.683]. *Amphetamines [D02.092.471.683.152]. Below are MeSH descriptors ...
Designing Potential Antitrypanosomal Thiazol-2-ethylamines through Predictive Regression Based and Classification Based QSAR ... Designing Potential Antitrypanosomal Thiazol-2-ethylamines through Predictive Regression Based and Classification Based QSAR ...
Categories: Ethylamines Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 10 ...
"Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors". Bioorganic & Medicinal Chemistry Letters. 20 (9 ...
Ethylamines: 5*Phenethylamines: 14*Dimethoxyphenylethylamine: 5*2-(4-bromo-2,5-dimethoxyphenyl)ethylamine: 2 ...
Ethylamines: 5*Phenethylamines: 14*1-(2,5-dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane ...
Important products from ethanol are: Ethylamines, yeast, acetaldehyde, and ethyl acetate.[8] ...
Addition of 2-Lithiothiazoles to ROPHy/SOPHy Aldoximes: Asymmetric Synthesis of 1-(2-Thiazolyl)ethylamines Synlett. SPI, 984- ...
2-(alkoxy benzothiazolinon-3yl) ethylamines. Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in ...
2-(alkoxy benzothiazolinon-3yl) ethylamines US5436348A (en) * 1991-03-25. 1995-07-25. Adir Et Compagnie. Benzoxazolinonyl ...
BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character. Bioorg. Med. Chem. Lett ...
Ethyl amines are converted to nitrogen dioxide, carbon dioxide and water. This occurs in candle flames, furnaces, fireplaces, ...
... ethylamine)- s -triazine (simazine). ...
... he discovered methyl and ethyl amines (1849), glycol (1856), and aldol condensation (1872). He developed (1855) a method of ...
Catalytic enantioselective synthesis of α-chiral azaheteroaryl ethylamines by asymmetric protonation. Watson, A. J. B., Xu, C ...
Kunda is lead manufacturer of Ethyl amines, Pyridine, Beta-picoline, 3-Cyanopyridine, Niacinamide, Piperidine and ...
ethylamines, aldehydes, and higher alcohols, especially butanol. In the production of ethyl acetate, the finished ethanol ...
These include ethyl halides, ethyl esters, diethyl ether, acetic acid, butadiene, and ethyl amines. ...
As shown in , the tris-ethylamines 3c and 3e exhibit, respectively, Kis of 1.7 and 2.1 µM, among the lowest reported for such ...
Aromatic ethylamines afforded good yields of pyrrole derivatives.. Scheme 17: Synthesis of 1,3,4 trisubstituted pyrrole ...
  • Group I and Group II cations, and amines including methylamines, ethylamines, ethanolamines, and alkanolamines in diverse sample matrices. (thermofisher.com)
  • In May 1995, it came out with a public issue of 9.63 lakh equity shares (premium: Rs 30), aggregating Rs 3.85 crore to part-finance expansion plans for ethylamines and forward integration for the manufacture of derivatives of methyl and ethyl amines, totaling to Rs 10 crore. (mergersindia.com)
  • Acetonitrile can be used to optimize the resolution of ethylamines from Group I and Group II cations. (dionex.su)
  • De Costa et al (1992) Synthesis, characterization, and biological evaluation of a novel class of N -(arylethyl)- N -alkyl-2-(1-pyrrolidinyl)ethylamines - structural requirements and binding affinity at the σ receptor. (tocris.com)
  • Synthesis and activity of some N-substituted alpha-(2-n-hexyl-4,5-dimethoxyphenyl) ethylamines against Entamoeba histolytica. (iiislandassert9.icu)