Deanol
Carcinogenicity of triethanolamine in mice and its mutagenicity after reaction with sodium nitrite in bacteria. (1/1992)
Mice fed a diet containing 0.3 or 0.03% triethanolamine developed malignant tumors. Females showed a high incidence of tumors in lymphoid tissues, while this type was absent in males. Tumors in other tissues were produced at a considerable rate in both sexes, but no hepatoma was found. Triethanolamine was not mutagenic to Bacillus subtilis by itself, but it became mutagenic after reacting with sodium nitrite under acidic conditions or when the mixture was heated. Although N-nitrosodiethanolamine, a known carcinogen and mutagen, was detected in the reaction mixture by thin-layer chromatography, it may not be the main mutagenic product, because the product was a stable and direct mutagen and its mutagenic activity was destroyed by liver enzymes, unlike N-nitrosodiethanolamine. The lethal and mutagenic DNA damages produced by this unidentified product were susceptible to some extent to the repair functions of the bacteria. (+info)Dietary control of triglyceride and phospholipid synthesis in rat liver slices. (2/1992)
1. The effect of dietary manipulation on the synthesis of triglycerides and phospholipids was investigated by determining the incorporation of labeled long-chain fatty acid or glycerol into these lipids in liver slices derived from normally fed, fasted, and fat-free refed rats. 2. Triglyceride synthesis was affected markedly by the dietary regime of the animal; the lowest rates were measured with fasted rats, and the highest ones with fat-free refed rats. 3. In contrast to triglyceride synthesis, phospholipid synthesis occured at virtually constant rates regardless of the dietary conditions. 4. Addition of large amounts of fatty acid to the incubation mixture resulted in a marked stimulation of triglyceride synthesis, whereas phospholipid synthesis was affected to a much smaller extent. 5. These results indicate that the synthesis of triglycerides and that of phospholipids are controlled independently, and that the availability of fatty acid in the cell contributes to the control of triglyceride synthesis. (+info)Kinetic analysis of drug-receptor interactions of long-acting beta2 sympathomimetics in isolated receptor membranes: evidence against prolonged effects of salmeterol and formoterol on receptor-coupled adenylyl cyclase. (3/1992)
The long-acting beta2 sympathomimetics salmeterol and formoterol have been presumed to exert their prolonged action either by binding to an accessory binding site ("exo-site") near the beta2 adrenoceptor or by their high affinity for beta2 adrenoceptors and correspondingly slow dissociation. Whereas most studies with salmeterol had been done in intact tissues, which have slow diffusion and compartmentation of drugs in lipophilic phases, that restrict drug access to the receptor biophase, we used purified receptor membranes from rat lung and disaggregated calf tracheal myocytes as model systems. Binding experiments were designed to measure the slow dissociation of agonists by means of delayed association of (-)-[125I]iodopindolol. Rat lung membranes were pretreated with high concentrations of agonists (salmeterol, formoterol, isoprenaline) before dissociation was induced by 50-fold dilution. Half-times of association of (-)-[125I]iodopindolol remained unchanged compared with untreated controls, indicating that dissociation of agonists occurred in less than 2 min. Adenylyl cyclase experiments were designed to determine the on and off kinetics of agonists to beta2 adrenoceptors by measuring the rate of receptor-induced cyclic AMP (cAMP) formation. Experiments were performed in tracheal membranes characterized by high Vmax values of cAMP formation. Adenylyl cyclase activation occurred simultaneously with the addition of the agonist, continued linearly with time for 60 min, and ceased immediately after the antagonist was added. Similarly, when receptor membranes were preincubated in a small volume with high salmeterol concentrations, there was a linear increase in cAMP formation, which was immediately interrupted by a 100-fold dilution of the reaction mixture. This militates against the exo-site hypothesis. On the other hand, dissociation by dilution was much less when membranes were preincubated with a large volume of salmeterol at the same concentration, indicating that physicochemical effects, and not exo-site binding, underlie its prolonged mode of action. (+info)Beta2-adrenoceptor polymorphism and bronchoprotective sensitivity with regular short- and long-acting beta2-agonist therapy. (4/1992)
The aim of the present study was to investigate bronchoprotective sensitivity in patients receiving regular treatment with short- and long-acting beta2-agonists and to evaluate any possible association with genetic polymorphism. Thirty-eight patients with stable mild to moderate asthma and receiving inhaled corticosteroids were randomized in a parallel group, double-blind, double-dummy fashion to receive 2 weeks of treatment with either formoterol (12 microg once daily, 6 microg twice daily or 24 microg twice daily) or terbutaline (500 microg four times daily). Bronchoprotection against methacholine challenge (as a provocative dose to produce a 20% fall in forced expiratory volume in 1.0 s: PD20) was measured at baseline (unprotected) after an initial 1 week run-in without beta2-agonist, and at 1 h after the first and last doses of each treatment. The PD20 values were log-transformed and calculated as change from baseline. Percentage desensitization of log PD20 for first- versus last-dose bronchoprotection was calculated and analysed according to effects of treatment and beta2-adrenoceptor polymorphism at codon 16 or 27. The mean degree of desensitization for bronchoprotection was comparable with all four treatments and there were no significant differences in absolute PD20 values after 2 weeks of chronic dosing. The PD20 values were (as microg of methacholine, geometric means+/-S. E.M.): formoterol, 12 microg once daily, 99+/-42 microg; formoterol, 6 microg twice daily, 107+/-44 microg; formoterol, 24 microg twice daily, 108+/-45 microg; terbutaline, 500 microg four times daily, 88+/-37 microg. All patients receiving formoterol, 24 microg twice daily, exhibited a loss of protection greater than 30% which was unrelated to polymorphism at codon 16 or 27. For codon 16, the use of lower doses of formoterol (12 microg once daily or 6 microg twice daily) showed wider variability in the propensity for protection loss in patients who were heterozygous, in contrast to a more uniform protection loss seen with homozygous glycine patients. The amount of protection loss was not significantly related to polymorphism at codon 16 or 27, expressed as values (mean+/-S.E.M.) for percentage desensitization according to each genotype (pooled treatments): Gly-16, 66+/-11%; Het-16, 53+/-8%; Arg-16, 69+/-18%; Glu-27, 68+/-12%; Het-27, 58+/-8%; Gln-27, 52+/-12%. The results of this preliminary study showed that bronchoprotective desensitization occurred readily in response to short- or long-acting beta2-agonist exposure irrespective of beta2-adrenoceptor polymorphism at codon 16 or 27. Further studies with larger patient numbers are required to further evaluate the effects of polymorphisms with lower doses of regular formoterol. (+info)Effects of tumour necrosis factor-alpha on left ventricular function in the rat isolated perfused heart: possible mechanisms for a decline in cardiac function. (5/1992)
1. The cardiac depressant actions of TNF were investigated in the isolated perfused rat heart under constant flow (10 ml min(-1)) and constant pressure (70 mmHg) conditions, using a recirculating (50 ml) mode of perfusion. 2. Under constant flow conditions TNF (20 ng ml(-1)) caused an early (< 25 min) decrease in left ventricular developed pressure (LVDP), which was maintained for 90 min (LVDP after 90 min: control vs TNF; 110 +/- 4 vs 82 +/- 10 mmHg, P < 0.01). 3. The depression in cardiac function seen with TNF under constant flow conditions, was blocked by the ceramidase inhibitor N-oleoylethanolamine (NOE), 1 microM, (LVDP after 90 min: TNF vs TNF with NOE; 82 +/- 10 vs 11 +/- 5 mmHg, P < 0.05). 4. In hearts perfused at constant pressure, TNF caused a decrease in coronary flow rate (change in flow 20 min after TNF: control vs TNF; -3.0 +/- 0.9 vs -8.7 +/- 1.2 ml min(-1), P < 0.01). This was paralleled by a negative inotropic effect (change in LVDP 20 min after TNF: control vs TNF; -17 +/- 7 vs -46 +/- 6 mmHg, P < 0.01). The decline in function was more rapid and more severe than that seen under conditions of constant flow. 5. These data indicate that cardiac function can be disrupted by TNF on two levels, firstly via a direct, ceramidase dependant negative inotropic effect, and secondly via an indirect coronary vasoconstriction. (+info)MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast. (6/1992)
Glycosylphosphatidylinositol (GPI)-anchored proteins are cell surface-localized proteins that serve many important cellular functions. The pathway mediating synthesis and attachment of the GPI anchor to these proteins in eukaryotic cells is complex, highly conserved, and plays a critical role in the proper targeting, transport, and function of all GPI-anchored protein family members. In this article, we demonstrate that MCD4, an essential gene that was initially identified in a genetic screen to isolate Saccharomyces cerevisiae mutants defective for bud emergence, encodes a previously unidentified component of the GPI anchor synthesis pathway. Mcd4p is a multimembrane-spanning protein that localizes to the endoplasmic reticulum (ER) and contains a large NH2-terminal ER lumenal domain. We have also cloned the human MCD4 gene and found that Mcd4p is both highly conserved throughout eukaryotes and has two yeast homologues. Mcd4p's lumenal domain contains three conserved motifs found in mammalian phosphodiesterases and nucleotide pyrophosphases; notably, the temperature-conditional MCD4 allele used for our studies (mcd4-174) harbors a single amino acid change in motif 2. The mcd4-174 mutant (1) is defective in ER-to-Golgi transport of GPI-anchored proteins (i.e., Gas1p) while other proteins (i.e., CPY) are unaffected; (2) secretes and releases (potentially up-regulated cell wall) proteins into the medium, suggesting a defect in cell wall integrity; and (3) exhibits marked morphological defects, most notably the accumulation of distorted, ER- and vesicle-like membranes. mcd4-174 cells synthesize all classes of inositolphosphoceramides, indicating that the GPI protein transport block is not due to deficient ceramide synthesis. However, mcd4-174 cells have a severe defect in incorporation of [3H]inositol into proteins and accumulate several previously uncharacterized [3H]inositol-labeled lipids whose properties are consistent with their being GPI precursors. Together, these studies demonstrate that MCD4 encodes a new, conserved component of the GPI anchor synthesis pathway and highlight the intimate connections between GPI anchoring, bud emergence, cell wall function, and feedback mechanisms likely to be involved in regulating each of these essential processes. A putative role for Mcd4p as participating in the modification of GPI anchors with side chain phosphoethanolamine is also discussed. (+info)Effects of beta2-adrenergic stimulation on single-channel gating of rat cardiac L-type Ca2+ channels. (7/1992)
Cardiac L-type Ca2+ channels can be stimulated by activation of beta2-adrenoceptors. We intended to determine how the gating behavior at the single-channel level (cell-attached configuration) is affected after selective stimulation of beta2-adrenoceptors. Rat cardiomyocytes were exposed to zinterol, a beta2-agonist (n = 7), isoproterenol (n = 6), a nonselective agonist, 8-bromo-cAMP (n = 6), and a combination of isoproterenol and ICI-118551 (n = 8), a selective beta2-receptor antagonist, or isoproterenol and CGP-20712A, a beta1-selective antagonist (n = 7). In all groups the ensemble-average current and the availability of the channels to open on depolarization were increased in a similar fashion. In addition, the open probability (Po) within active sweeps was elevated. However, zinterol exerted this effect in a unique manner. It elevated Po not by shortening closed times but solely by reducing active sweeps with very low Po and a short burst duration. All zinterol effects were abolished by ICI-118551 (n = 5) and mimicked by isoproterenol plus CGP-20712A (n = 7). We conclude that beta2-adrenoceptor activation of L-type channels differs qualitatively from the classical cAMP-dependent mechanism. (+info)A randomized, double-blind, comparative trial of a new oral combination of artemether and benflumetol (CGP 56697) with mefloquine in the treatment of acute Plasmodium falciparum malaria in Thailand. (8/1992)
CGP 56697, a new oral fixed combination of artemether and benflumetol, was tested in a double-blinded, randomized trial in 252 adult patients treated either with CGP 56697 (4 x 4 tablets each containing 20 mg of artemether and 120 mg of benflumetol, given at 0, 8, 24, and 48 hr), or with mefloquine (three tablets of 250 mg at initial diagnosis, followed by two tablets of 250 mg at 8 hr). Baseline data of the two groups were comparable. The 28-day cure rate with CGP 56697 was lower than with mefloquine (69.3% versus 82.4%; P = 0.002). However, CGP 56697 was more effective than mefloquine in parasite clearance time (43 hr versus 66 hr; P < 0.001) fever clearance time (32 hr versus 54 hr; P < 0.005), and gametocyte clearance time (152 hr versus 331 hr; P < 0.001). This study revealed that CGP 56697 is effective against multidrug-resistant Plasmodium falciparum malaria in Thailand, but higher doses will probably be needed to improve the cure rate. (+info)
Identification of the histidyl residue of rabbit muscle aldolase alkylated by N-bromoacetylethanolamine phosphate.
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Ethanolamine
... is biosynthesized by decarboxylation of serine: HOCH 2CH(CO 2H)NH 2 → HOCH 2CH 2NH 2 + CO2 Ethanolamine is the ... The ethanolamines comprise a group of amino alcohols. A class of antihistamines is identified as ethanolamines, which includes ... Ethanolamine is a colorless, viscous liquid with an odor reminiscent of ammonia.. ETA molecules are a component in the ... Derivatives of ethanolamine are widespread in nature; e.g., lipids, as precursor of a variety of N-acylethanolamines (NAEs), ...
Ethanolamine kinase
In enzymology, an ethanolamine kinase (EC 2.7.1.82) is an enzyme that catalyzes the chemical reaction ATP + ethanolamine ⇌ {\ ... Other names in common use include ethanolamine kinase (phosphorylating), and ethanolamine phosphokinase. This enzyme ... Sung CP, Johnstone RM (1967). "Phosphorylation of choline and ethanolamine in Ehrlich ascites-carcinoma cells". Biochem. J. 105 ... Weinhold PA, Rethy VB (1972). "Ethanolamine phosphokinase: activity and properties during liver development" (PDF). Biochim. ...
Ethanolamine oxidase
In enzymology, an ethanolamine oxidase (EC 1.4.3.8) is an enzyme that catalyzes the chemical reaction ethanolamine + H2O + O2 ... Narrod SA, Jakoby WB (1964). "Metabolism of ethanolamine. An ethanolamine oxidase". J. Biol. Chem. 239: 2189-2193. doi:10.1016/ ... The systematic name of this enzyme class is ethanolamine:oxygen oxidoreductase (deaminating). It has 2 cofactors: cobalt, and ... displaystyle \rightleftharpoons } glycolaldehyde + NH3 + H2O2 The 3 substrates of this enzyme are ethanolamine, H2O, and O2, ...
Ethanolamine ammonia-lyase
The enzyme ethanolamine ammonia-lyase (EC 4.3.1.7) catalyzes the chemical reaction ethanolamine ⇌ {\displaystyle \ ... The systematic name of this enzyme class is ethanolamine ammonia-lyase (acetaldehyde-forming). It is also called ethanolamine ... II Requirement for a cobamide coenzyme by an ethanolamine deaminase". J. Biol. Chem. 240 (12): 4675-81. PMID 5846988. Kaplan BH ... Bradbeer C (1965). "The clostridial fermentations of choline and ethanolamine. 1 Preparation and properties of cell-free ...
Ethanolamine-O-sulfate
... (EOS) is an ester of sulfuric acid and ethanolamine. EOS is a GABA transaminase inhibitor which prevents ... "Anticonvulsant action of ethanolamine-O-sulfate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice ... "Ethanolamine-O-sulfate enhances gamma-aminobutyric acid secretion into hypophysial portal blood and lowers serum prolactin ...
Ethanolamine-phosphate cytidylyltransferase
CDP-ethanolamine Thus, the two substrates of this enzyme are CTP and ethanolamine phosphate, whereas its two products are ... "2-Aminoethylarsonic acid as an analogue of ethanolamine phosphate Endowment of ethanolamine-phosphate cytidylyltransferase with ... In enzymology, an ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) is an enzyme that catalyzes the chemical reaction ... ethanolamine-phosphate cytidylyltransferase. Other names in common use include phosphorylethanolamine transferase, ET, CTP- ...
Ethanolamine-phosphate phospho-lyase
The enzyme ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) catalyzes the chemical reaction ethanolamine phosphate + H2O ⇌ {\ ... Metabolism of ethanolamine and 1-aminopropan-2-ol in species of Erwinia and the roles of amino alcohol kinase and amino alcohol ... The systematic name of this enzyme class is ethanolamine-phosphate phosphate-lyase (deaminating; acetaldehyde-forming). Other ... and ethanolamine-phosphate phospho-lyase (deaminating). It employs one cofactor, pyridoxal phosphate. Fleshood HL, Pitot HC ( ...
N-(long-chain-acyl)ethanolamine deacylase
... ethanolamine Thus, the two substrates of this enzyme are N-(long-chain-acyl)ethanolamine and H2O, whereas its two products are ... In enzymology, a N-(long-chain-acyl)ethanolamine deacylase (EC 3.5.1.60) is an enzyme that catalyzes the chemical reaction N-( ... The systematic name of this enzyme class is N-(long-chain-acyl)ethanolamine amidohydrolase. Other names in common use include N ... long-chain-acyl)ethanolamine + H2O ⇌ {\displaystyle \rightleftharpoons } a long-chain carboxylate + ...
Choline chloride
Matthias Frauenkron, Johann-Peter Melder, Günther Ruider, Roland Rossbacher, Hartmut Höke (2002). "Ethanolamines and ...
Propanolamines
"Ethanolamines and Propanolamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007. ...
3-Amino-1-propanol
Frauenkron, Matthias; Melder, Johann-Peter; Ruider, Günther; Rossbacher, Roland; Höke, Hartmut (2001). "Ethanolamines and ...
Tyrosinol
The compound, which is chiral, is an example of a 1,2-ethanolamine. tyrosol, HOC6H4CH2CH2OH Phoon, Chee Wee; Abell, Chris (1998 ... "Ethanolamines and Propanolamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007. ...
Alkanolamine
Key members: ethanolamine, dimethylethanolamine, N-methylethanolamine, Aminomethyl propanol Two popular drugs, often called ... Isoetarine is yet another medicinally useful derivative of ethanolamine. 2-Aminoalcohols are an important class of organic ... Alkanolamines methanolamine, an intermediate in the reaction of ammonia with formaldehyde Ethanolamine 2-amino-2-methyl-1- ... "Ethanolamines and Propanolamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007. ...
Propanolamine
Frauenkron, Matthias; Melder, Johann-Peter; Ruider, Günther; Rossbacher, Roland; Höke, Hartmut (2001). "Ethanolamines and ...
Triethanolamine
"Ethanolamines and Propanolamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007. ... Lessmann, H.; Uter, W.; Schnuch, A.; Geier, J. (2009). "Skin sensitizing properties of the ethanolamines mono-, di-, and ... Triethanolamine is produced from the reaction of ethylene oxide with aqueous ammonia, also produced are ethanolamine and ... Complexometric titration Ethanolamine Ethanol Triethanolamine salicylate "Front Matter". Nomenclature of Organic Chemistry : ...
Dimethylethanolamine
Choline Diphenhydramine Doxylamine Ethanolamine Meclofenoxate (Centrophenoxine) Orphenadrine Littel, RJ; Bos, M; Knoop, GJ ( ... Matthias Frauenkron, Johann-Peter Melder, Günther Ruider, Roland Rossbacher, Hartmut Höke (2002). "Ethanolamines and ...
Monoethanolamine oleate
"Ethanolamine Oleate". RXList. Retrieved 7 March 2020. v t e (Articles needing additional references from September 2019, All ... Ethanolamine Oleate (Ethanolamin) injection is indicated for the treatment of patients with esophageal varices that have ...
Oxazoline
"Syntheses from Ethanolamine. V. Synthesis of Δ2-Oxazoline and of 2,2'-Δ2-Dioxazoline". Journal of the American Chemical Society ...
Ethylene oxide
Ethanolamines are used in the manufacture of soap and detergents and for purification of natural gas. Ethoxylates are reaction ... Other important products include ethylene glycol ethers, ethanolamines and ethoxylates. Among glycols, ethylene glycol is used ... ISBN 0-8247-2470-4. "Technology of ethanolamine". Technology. Himtek Engineering. Archived from the original on 2 March 2005. ... ethanolamines. The reaction is stimulated by adding a small amount of water. (CH2CH2)O + NH3 → HO-CH2CH2-NH2 2 (CH2CH2)O + NH3 ...
N-Acylethanolamine
These amides conceptually can be formed from a fatty acid and ethanolamine with the release of a molecule of water, but the ... N-Docosahexaenoyl ethanolamine (DHEA: C24H37NO2; 22:6, ω-3), or Anandamide (22:6, n-3) "synaptamide", is the amide of ... The hydrolysis of NAE to free fatty acid (FFA) and ethanolamine (MEA) in animals, is catalyzed by fatty acid amide hydrolase ( ... NAE 20:4 (AEA: C22H37NO2; 20:4, ω-6) is the amide of arachidonic acid (C20H32O2; 20:4, ω-6) and ethanolamine (MEA: C2H7NO). NAE ...
Virodhamine
O-Arachidonoyl ethanolamine is arachidonic acid and ethanolamine joined by an ester linkage, the opposite of the amide linkage ... Virodhamine (O-arachidonoyl ethanolamine; O-AEA) is an endocannabinoid and a nonclassic eicosanoid, derived from arachidonic ...
Piroctone olamine
... is the ethanolamine salt of the hydroxamic acid derivative piroctone. It is often used in anti-dandruff ... Piroctone olamine (INN; also known as piroctone ethanolamine;) is a compound sometimes used in the treatment of fungal ... Ethanolamines, 2-Pyridones, Cosmetics chemicals, All stub articles, Dermatologic drug stubs, Antiinfective agent stubs). ...
CHKB (gene)
Choline kinase beta (CK), also known as Ethanolamine kinase (EK), Choline kinase-like protein , choline/ethanolamine kinase ... However, it has been shown that the protein has higher activity with ethanolamine and may not significantly contribute to in ... "CHKB - Choline/ethanolamine kinase - Homo sapiens (Human) - CHKB gene & protein". Retrieved 2018-08-23. This article ... The choline kinase (CK) and ethanolamine kinase (EK) proteins, which are coded by the CHKB gene, catalyze the phosphorylation ...
Sphingolipid
This forms ethanolamine phosphate and hexadecenal. Sphingolipids are commonly believed to protect the cell surface against ... The sphingosine backbone is O-linked to a (usually) charged head group such as ethanolamine, serine, or choline.[citation ...
Diethanolamine
It has an advantage over a similar amine, ethanolamine, in that a higher concentration may be used for the same corrosion ... Matthias Frauenkron, Johann-Peter Melder, Günther Ruider, Roland Rossbacher, Hartmut Höke "Ethanolamines and Propanolamines" in ... The reaction of ethylene oxide with aqueous ammonia first produces ethanolamine: C2H4O + NH3 → H2NCH2CH2OH which reacts with a ... "Skin sensitizing properties of the ethanolamines mono-, di-, and triethanolamine. Data analysis of a multicentre surveillance ...
Triethylamine
"Ethanolamine Compounds (MEA, DEA, TEA And Others)". Safe Cosmetics. Retrieved 2020-06-17. "tetraethylammonium , Ligand page , ...
Alkaline copper quaternary
The copper in the preparation is in the form of a soluble complex with ammonia NH3 or an amine such as ethanolamine N(C2H5)H2. ... The formulations with ethanolamine, especially ACQ-D, are generally used for easier woods (such as southern pine) because it ... Otherwise ethanolamine is preferred as copper carrier. Quaternary ammonium cations The quaternary ammonium cation in some ... Types registered in the US and Canada: ACQ-A: copper-ethanolamine (50% CuO equivalent), and DDA chloride (50%). ACQ-B: copper- ...
Phosphatidylethanolamine
... phosphatidylethanolamine is also made via the cytidine diphosphate-ethanolamine pathway, using ethanolamine as the substrate. ... Whereas the phosphate group is combined with choline in phosphatidylcholine, it is combined with the ethanolamine in ... N-Acylphosphatidylethanolamine Phosphatidyl ethanolamine methyltransferase Wellner, Niels; Diep, Thi Ai; Janfelt, Christian; ... They are synthesized by the addition of cytidine diphosphate-ethanolamine to diglycerides, releasing cytidine monophosphate. S- ...
N-Methylethanolamine
The poly(methyl-ethanolamine) formed by further addition of ethylene oxide to methylethanolamine remains in the distillation ... Ltd.: Methyl Ethanolamines Technology Archived 2016-03-06 at the Wayback Machine (PDF; 152 kB). Product Safety Assessment, DOW ... Ethanolamine Dimethylethanolamine Merck Index, 12th Edition, 6096. Matthias Frauenkron, Johann-Peter Melder, Günther Ruider, ... where it is used together with its analogs ethanolamine and dimethylethanolamine. N-Methylethanolamine is produced industrially ...
Anandamide
It is degraded primarily by the fatty acid amide hydrolase (FAAH) enzyme, which converts anandamide into ethanolamine and ... Natarajan V, Reddy PV, Schmid PC, Schmid HH (August 1982). "N-Acylation of ethanolamine phospholipids in canine myocardium". ... which breaks it down into free arachidonic acid and ethanolamine. Studies of piglets show that dietary levels of arachidonic ...
1988 OSHA PEL Project - Ethanolamine | NIOSH | CDC
The health hazards associated with exposures to ethanolamine include irritation and necrosis of the skin and central nervous ... In the final rule, OSHA is establishing a PEL of 3 ppm as an 8-hour TWA and a 15-minute STEL of 6 ppm for ethanolamine. The ... OSHA formerly had an 8-hour TWA limit of 3 ppm for ethanolamine. The ACGIH has the same TWA limit, along with a 15-minute STEL ... Ethanolamines irritant and necrotic effects on the skin are not related to its alkalinity (Hinglais 1947/Ex. 1-909). OSHA ...
Parcourir par sujet "ETHANOLAMINE"
English
Studies of Oxide Layers Grown at 260°C on A106 B Carbon Steel in Aqueous Medium with Ethanolamine or Morpholine
In this treatment, ammonia, morpholine and ethanolamine are commonly used as conditioning reagents. In this context, ... ethanolamine during different exposure periods up to ≈1020 h. The oxide film characterization was mainly studied using Scanning ... There are two main options of what to add ammonia or an amine (such as morpholine, ethanolamine (ETA)) and nowadays there are ... Studies of Oxide Layers Grown at 260˚C on A106 B Carbon Steel in Aqueous Medium with Ethanolamine or Morpholine ...
Ethanolamines - Chemical Safety Facts
Ethanolamines are a family of chemicals that work as surfactants and emulsifying ingredients in personal care and cleaning ... EthanolaminesMay also be known as: Monoethanolamine (MEA), Diethanolamine (DEA), Triethanolamine (TEA). Ethanolamines are a ... Because ethanolamines dont impart a strong odor, they are commonly ingredients in products like hair dye. Ethanolamines like ... Ethanolamines like MEA work as cleansing agents, or surfactants, in personal care products and cosmetics. In these types of ...
The Science of Clean Skin Care and the Clean Beauty Movement
Why Are Ethanolamines Sometimes Considered Safe and Sometimes Not? Ethanolamines are reputed to be allergenic, but as we know ... What Is the Bottom Line? Are Ethanolamines Safe in Cosmetics? For now, if a patient asks if ethanolamine is safe in skin care, ... Considering ethanolamines as the example here, note that cocamide DEA is an ethanolamine derived from coconut. It is often ... Are Ethanolamines Safe or Toxic in Cosmetics? Ethanolamines are common ingredients in surfactants, fragrances, and emulsifying ...
ETHANOLAMINES | NNS Chemicals (Private) Limited.
Ethanolamine, also known as Mono-Ethanol-Amine (often abbreviated as MEA), is an organic chemical compound which is both a ... Ethanolamine, also known as Mono-Ethanol-Amine (often abbreviated as MEA), is an organic chemical compound which is both a ... Ethanolamine, also known as Mono-Ethanol-Amine (often abbreviated as MEA), is an organic chemical compound which is both a ... Ethanolamine, also known as Mono-Ethanol-Amine (often abbreviated as MEA), is an organic chemical compound which is both a ...
Ethanolamine oleate use as an alternative to surgical treatment of oral hemangiomas: a case report
IMSEAR at SEARO: Ethanolamine plasmalogen & cholesterol ester metabolism in experimental allergic encephalomyelitis.
Ethanolamine Oleate (Ethamolin) Reviews | Everyday Health
See what others have said about Ethanolamine Oleate (Ethamolin), including the effectiveness, ease of use and side effects. ... Ethanolamine Oleate (Ethamolin) received an overall rating of 0 out of 10 stars from 0 reviews. ... Ethanolamine Oleate (Ethamolin) Reviews. Be the first to review Ethanolamine Oleate (Ethamolin) and share your experience with ...
Borofix Boron Ethanolamine - 10% : Micronutrient Fertilizer
Pharmacotherapy for Nonallergic Rhinitis: Overview, Distinguishing Types of Nonallergic Rhinitis, Pharmacotherapy
Mono ethanol amine Distributor,Supplier,Trader In Delhi NCR
ATSDR - Hazardous Substances Emergency Events Surveillance (HSEES) 1996
KEGG REACTION: R02057
Ethanolamine (2-Aminoethanol, Monoethanolamine) extrapure AR, 99% - Krins Life Sciences
Global Amines by Product, Market and Region, 3rd Edition - Market Size, Market Share, Market Leaders, Demand Forecast, Sales,...
PIGO gene: MedlinePlus Genetics
The PIGO gene provides instructions for making one part of an enzyme called GPI ethanolamine phosphate transfer 3 (GPI-ET3). ... The PIGO gene provides instructions for making one part of an enzyme called GPI ethanolamine phosphate transfer 3 (GPI-ET3). ... The altered protein is less able to add ethanolamine phosphate to the end of GPI anchors. The incomplete GPI anchor cannot ... Specifically, this enzyme adds a molecule of ethanolamine phosphate to the end of the forming GPI anchor. This step takes place ...
MIC Assistant Professor Melissa Kendall, PhD receives RO1 for "Ethanolamine Signaling in Virulence Gene Regulation and Host...
Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus long-acting beta(2)-agonists for chronic...
NIOSHTIC-2 Search Results - Full View
Ethanol Amine, 18.5-370 PPM, SMA-3 | Colorimetric Stain Tubes | Uniphos Tubes
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EWG's Guide to Healthy Cleaning | All Oxi Mighty Pacs Cleaner Rating
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Körper, Haar & Nägel » online kaufen | NICHE BEAUTY
How Do Sclerosing Agents Work? - Uses, Side Effects, Drug Names
Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global...
Garsin, D. A. Ethanolamine utilization in bacterial pathogens: roles and regulation. Nat. Rev. Microbiol. 8, 290-295 (2010). ... Kp has two operons involved in ethanolamine metabolism: eutRKLCBAHGJENMDTQP and eat-eutBC. The former is typically associated ... Both grew on ethanolamine with no apparent differences in efficiency52, indicating no detrimental effect of the loss of Eat in ... and the other was an ISKpn1 transposase inserted within an ethanolamine transporter gene, eat (KP1_1165 in NTUH-K2044). ...
Minutes of the 159th Meeting of the NATIONAL ADVISORY COUNCIL ON ALCOHOL ABUSE AND ALCOHOLISM | National Institute on Alcohol...
Ethanol, 2-[(2-aminoethyl)amino]
... ethanolamine; N-(β-Hydroxyethyl)ethylenediamine; N-(Aminoethyl)ethanolamine; N-(Hydroxyethyl)ethylenediamine; N-(2-Aminoethyl) ... 1-Aminoethyl ethanolamine; (2-Aminoethyl)ethanolamine; Aminoethylethanolamine; Monoethanolethylenediamine; Ethanolethylene ... ethanolamine; N-(2-Hydroxyethyl)-1,2-ethanediamine; N-(2-Hydroxyethyl)ethylenediamine; N-Hydroxyethyl-1,2-ethanediamine; 1-[2-( ...
Oleate4
- Be the first to review Ethanolamine Oleate (Ethamolin) and share your experience with other Everyday Health users. (everydayhealth.com)
- Endoscopic injection sclerotherapy was performed using 5% ethanolamine oleate with contrast medium under fluoroscopy. (ispub.com)
- Ethanolamine oleate was injected into the "Angel halo" varix. (ispub.com)
- Aqua/Water/Eau - Cetearyl Alcohol - Propylene Glycol - Maleic Acid - Behentrimonium Methosulfate - Ethanolamine - Stearamidopropyl Dimethylamine - Glycerin - Phenoxyethanol - Hydroxyethylcellulose - Parfum/Fragrance - Quaternium-91 - Polyquaternium-37 - Benzoic Acid - Paraffinum Liquidum/Mineral Oil/Huile Minerale - Cetrimonium Chloride - Cetrimonium Methosulfate - PPG-1 Trideceth-6 - Acrylates Copolymer - Hexyl Cinnamal - Linalool - 2-Oleamido-1,3-Octadecanediol - Citronellol - Sorbitan Oleate. (benibanabeautyhub.com)
EDTA1
- Without paraben, ethanolamine and without EDTA. (luminateco.ca)
PHOSPHATIDYL ETHANOLAMINE1
- Low levels are associated with hyperthyroidism, and with the rare condition of idiopathic hypophosphatasia associated with rickets and the excretion of excess phosphatidyl ethanolamine in the urine. (cdc.gov)
Monoethanolamine3
- Common ethanolamines include monoethanolamine (MEA), diethanolamine (DEA), and triethanolamine (TEA). (chemicalsafetyfacts.org)
- Ethanolamines are common ingredients in surfactants, fragrances, and emulsifying agents and include cocamide diethanolamine (DEA), cocamide monoethanolamine (MEA), and triethanolamine (TEA). (medscape.com)
- Ethanolamine (2-aminoethanol, monoethanolamine, ETA, or MEA) is an organic chemical compound with the formula HOCH2CH2NH2 (C2H7NO). (brenntag.com)
Viscous liquid with an odor2
- Ethanolamine is a colorless, viscous liquid with an odor reminiscent of ammonia. (brenntag.com)
- Ethanolamine is a toxic flammable corrosive colorless viscous liquid with an odor similar to ammonia. (nnschemicals.com)
Colorless1
- Ethanolamine is a colorless liquid with a mild smell like that of ammonia. (cdc.gov)
Amines3
- There are two main options of what to add ammonia or an amine (such as morpholine, ethanolamine (ETA)) and nowadays there are made experiences in laboratories also with other amines like dimethylamine (DMA) [2] , to be used either in nuclear or and fossil plants. (scirp.org)
- Pesticides are the largest market for amines, a result of the use of ethanolamines and alkylamines in the synthesis of a wide variety of pesticides, including glyphosate, the world's most consumed pesticide active ingredient. (freedoniagroup.com)
- To determine the absorption of six amines used as corrosion inhibitors and biocides in MWFs, porcine skin flow-through diffusion cell experiments were conducted with hydrophilic ethanolamines (mono-, di- and triethanolamine, MEA, DEA and TEA respectively) and a mixture of lipophilic amines (dibutylethanolamine, dicyclohexylamine and diphenylamine). (cdc.gov)
Plasmalogen2
- IMSEAR at SEARO: Ethanolamine plasmalogen & cholesterol ester metabolism in experimental allergic encephalomyelitis. (who.int)
- The metabolic systems included 36-carbon ultra long-chain fatty acids, multiple choline-related systems including phosphatidylcholines, lysophosphatidylcholines and sphingomyelins, as well as vinyl ether-containing plasmalogen ethanolamines. (biomedcentral.com)
Surfactants3
- Ethanolamines are a family of chemicals that work as surfactants and emulsifying ingredients in personal care and cleaning products. (chemicalsafetyfacts.org)
- Ethanolamines like MEA work as cleansing agents, or surfactants, in personal care products and cosmetics. (chemicalsafetyfacts.org)
- As surfactants in these products, ethanolamines help remove dirt, grease and stains. (chemicalsafetyfacts.org)
PARFUM1
- Le Gloss T Colour Gel 1253392 F: Aqua/Water/Eau Cetearyl Alcohol Cocamidopropyl Betaine Behentrimonium Chloride Propylene Glycol Amodimethicone, Sclerotium Gum Hc Blue 2 Isopropyl Alcohol Sodium Chloride Phenoxyethanol Parfum/Fragrance Ethanolamine, Citric Acid 2-Nitro-5-Glyceryl Methylaniline Cocos Nucifera Oil/Coconut Oil Trideceth-6 Lunalool Hexyl Cinnamal Chlorhexidine Digluconate Basic Brown 17, Benzyl Salicylate Benzyl Alcohol Limonene Cetrimonium Chloride Amyl Cinnamal Coumarin Citronellol Alpha-Isomethyl Ionone, F.I.L. (cub.com)
Phosphate4
- The PIGO gene provides instructions for making one part of an enzyme called GPI ethanolamine phosphate transfer 3 (GPI-ET3). (medlineplus.gov)
- Specifically, this enzyme adds a molecule of ethanolamine phosphate to the end of the forming GPI anchor. (medlineplus.gov)
- this process requires the ethanolamine phosphate at the end of the anchor. (medlineplus.gov)
- The altered protein is less able to add ethanolamine phosphate to the end of GPI anchors. (medlineplus.gov)
Ammonia3
- The eye injury potential of ethanolamine is just slightly less than that of undiluted ammonia (Carpenter and Smyth 1946/Ex. (cdc.gov)
- In this treatment, ammonia, morpholine and ethanolamine are commonly used as conditioning reagents. (scirp.org)
- In many countries, alkaline reagents, ammonia, morpholine or ethanolamine are used to fix alkaline pH, which reduces the corrosion of the materials, (Pavagenau et al. (scirp.org)
Derivatives1
- Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. (nih.gov)
Exposure4
- The Agency concludes that both of these limits are required to protect workers against the significant risk of irritation and neuropathic effects, which constitute material health impairments that are potentially associated with exposure to ethanolamine at levels permitted above the 8-hour TWA limit. (cdc.gov)
- The tests were performed in a static autoclave at 260˚C using two media: I) hydrazine + morpholine and II) hydrazine + ethanolamine during different exposure periods up to »1020 h. (scirp.org)
- To protect workers in industrial settings, OSHA has established a permissible exposure limit (PEL) for ethanolamine at 3 ppm in the air and requires employers to control workplace exposure below that PEL. (chemicalsafetyfacts.org)
- To protect workers in industrial settings, the U.S. Department of Labor's Occupational Safety and Health Administration (OSHA) has established a Permissible Exposure Limit (PEL) for ethanolamine at 3 ppm in the air and requires employers to control workplace exposure below that PEL. (chemicalsafetyfacts.org)
Fatty2
- [5] It is degraded primarily by the fatty acid amide hydrolase (FAAH) enzyme, which converts anandamide into ethanolamine and arachidonic acid. (wikipedia.org)
- Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids. (nih.gov)
Irritation1
- The health hazards associated with exposures to ethanolamine include irritation and necrosis of the skin and central nervous system depression. (cdc.gov)
Common ingredients1
- Ethanolamines such as MEA are common ingredients in cleaning products like floor and tile cleaners, as well as laundry detergents. (chemicalsafetyfacts.org)
Toxic1
- Are Ethanolamines Safe or Toxic in Cosmetics? (medscape.com)
OSHA2
Compounds1
- When we used this assay to compare various synthetic LPA analogs at Edg-2, Edg-4, and Edg-7 receptors, we found that ethanolamine-based compounds, which are full LPA mimetics at Edg-2 and Edg-4, exhibit little activity at the Edg-7 receptor. (aspetjournals.org)
Powder1
- Meanwhile, 50% wettable powder of niclosamide ethanolamine salt (WPN) and clean water were used as controls. (bmsw.net.cn)
Gene1
- Novel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia. (cdc.gov)
Cosmetics3
- The Cosmetic Ingredient Review has found that ethanolamine ingredients are safe as currently used in cosmetics and personal care products. (chemicalsafetyfacts.org)
- The Cosmetic Ingredient Review (CIR), an independent expert scientific panel established by the Personal Care Products Council, has evaluated the safety of ethanolamine used in personal care products and cosmetics. (chemicalsafetyfacts.org)
- Wij bieden een breed gamma aan van top beauty producten met merken als Ofra Cosmetics, Astra Make-Up, Naturnua, You Are Cosmetics en veel meer. (lexcentrique.be)
Dirt1
- In these types of products, ethanolamines help remove dirt and oil on skin by dissolving grease and blending other important ingredients. (chemicalsafetyfacts.org)
Commonly1
- Because ethanolamines don't impart a strong odor, they are commonly ingredients in products like hair dye. (chemicalsafetyfacts.org)
Products1
- In its review, CIR has found that ethanolamine ingredients are safe as currently used in those products . (chemicalsafetyfacts.org)
Acid1
- Aqua/Water - Maleic Acid - Ethanolamine - CI 19140/Yellow 5 - CI 14700/Red 4 - CI 42090/Blue 1. (benibanabeautyhub.com)
Water1
- none type, the growing ingly soluble in water, with ethanolamine and sodium hydroxide or occur. (sdchirogroup.com)
Product1
- Ethanolamines like MEA help adjust the pH of a product to keep it from degrading when stored in a container so it will last longer. (chemicalsafetyfacts.org)
Chemical1
- Ethanolamine, also known as Mono-Ethanol-Amine (often abbreviated as MEA), is an organic chemical compound which is both a primary amine (due to an amino group in its molecule) and a primary alcohol (due to a hydroxyl group). (nnschemicals.com)
Salt1
- Pyridone Ethanolamine Salt-kuchepetsa kuyabwa/ster. (idenewmat.com)
Food3
- Rats fed 0.5 percent (320 mg/kg/day) ethanolamine in their food for 90 days (Smyth, Carpenter, and Weil 1951/Ex. (cdc.gov)
- FDA includes TEA, DEA and ethanolamine on its list of allowed indirect food additives. (chemicalsafetyfacts.org)
- The U.S. Food and Drug Administration (FDA) also includes TEA , DEA and ethanolamine on its list of allowed indirect food additives. (chemicalsafetyfacts.org)
Group1
- Ethanolamine is the second most abundant head group for phospholipids. (nnschemicals.com)