An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood.
AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.
Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).
A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.

Carcinogenicity of triethanolamine in mice and its mutagenicity after reaction with sodium nitrite in bacteria. (1/1992)

Mice fed a diet containing 0.3 or 0.03% triethanolamine developed malignant tumors. Females showed a high incidence of tumors in lymphoid tissues, while this type was absent in males. Tumors in other tissues were produced at a considerable rate in both sexes, but no hepatoma was found. Triethanolamine was not mutagenic to Bacillus subtilis by itself, but it became mutagenic after reacting with sodium nitrite under acidic conditions or when the mixture was heated. Although N-nitrosodiethanolamine, a known carcinogen and mutagen, was detected in the reaction mixture by thin-layer chromatography, it may not be the main mutagenic product, because the product was a stable and direct mutagen and its mutagenic activity was destroyed by liver enzymes, unlike N-nitrosodiethanolamine. The lethal and mutagenic DNA damages produced by this unidentified product were susceptible to some extent to the repair functions of the bacteria.  (+info)

Dietary control of triglyceride and phospholipid synthesis in rat liver slices. (2/1992)

1. The effect of dietary manipulation on the synthesis of triglycerides and phospholipids was investigated by determining the incorporation of labeled long-chain fatty acid or glycerol into these lipids in liver slices derived from normally fed, fasted, and fat-free refed rats. 2. Triglyceride synthesis was affected markedly by the dietary regime of the animal; the lowest rates were measured with fasted rats, and the highest ones with fat-free refed rats. 3. In contrast to triglyceride synthesis, phospholipid synthesis occured at virtually constant rates regardless of the dietary conditions. 4. Addition of large amounts of fatty acid to the incubation mixture resulted in a marked stimulation of triglyceride synthesis, whereas phospholipid synthesis was affected to a much smaller extent. 5. These results indicate that the synthesis of triglycerides and that of phospholipids are controlled independently, and that the availability of fatty acid in the cell contributes to the control of triglyceride synthesis.  (+info)

Kinetic analysis of drug-receptor interactions of long-acting beta2 sympathomimetics in isolated receptor membranes: evidence against prolonged effects of salmeterol and formoterol on receptor-coupled adenylyl cyclase. (3/1992)

The long-acting beta2 sympathomimetics salmeterol and formoterol have been presumed to exert their prolonged action either by binding to an accessory binding site ("exo-site") near the beta2 adrenoceptor or by their high affinity for beta2 adrenoceptors and correspondingly slow dissociation. Whereas most studies with salmeterol had been done in intact tissues, which have slow diffusion and compartmentation of drugs in lipophilic phases, that restrict drug access to the receptor biophase, we used purified receptor membranes from rat lung and disaggregated calf tracheal myocytes as model systems. Binding experiments were designed to measure the slow dissociation of agonists by means of delayed association of (-)-[125I]iodopindolol. Rat lung membranes were pretreated with high concentrations of agonists (salmeterol, formoterol, isoprenaline) before dissociation was induced by 50-fold dilution. Half-times of association of (-)-[125I]iodopindolol remained unchanged compared with untreated controls, indicating that dissociation of agonists occurred in less than 2 min. Adenylyl cyclase experiments were designed to determine the on and off kinetics of agonists to beta2 adrenoceptors by measuring the rate of receptor-induced cyclic AMP (cAMP) formation. Experiments were performed in tracheal membranes characterized by high Vmax values of cAMP formation. Adenylyl cyclase activation occurred simultaneously with the addition of the agonist, continued linearly with time for 60 min, and ceased immediately after the antagonist was added. Similarly, when receptor membranes were preincubated in a small volume with high salmeterol concentrations, there was a linear increase in cAMP formation, which was immediately interrupted by a 100-fold dilution of the reaction mixture. This militates against the exo-site hypothesis. On the other hand, dissociation by dilution was much less when membranes were preincubated with a large volume of salmeterol at the same concentration, indicating that physicochemical effects, and not exo-site binding, underlie its prolonged mode of action.  (+info)

Beta2-adrenoceptor polymorphism and bronchoprotective sensitivity with regular short- and long-acting beta2-agonist therapy. (4/1992)

The aim of the present study was to investigate bronchoprotective sensitivity in patients receiving regular treatment with short- and long-acting beta2-agonists and to evaluate any possible association with genetic polymorphism. Thirty-eight patients with stable mild to moderate asthma and receiving inhaled corticosteroids were randomized in a parallel group, double-blind, double-dummy fashion to receive 2 weeks of treatment with either formoterol (12 microg once daily, 6 microg twice daily or 24 microg twice daily) or terbutaline (500 microg four times daily). Bronchoprotection against methacholine challenge (as a provocative dose to produce a 20% fall in forced expiratory volume in 1.0 s: PD20) was measured at baseline (unprotected) after an initial 1 week run-in without beta2-agonist, and at 1 h after the first and last doses of each treatment. The PD20 values were log-transformed and calculated as change from baseline. Percentage desensitization of log PD20 for first- versus last-dose bronchoprotection was calculated and analysed according to effects of treatment and beta2-adrenoceptor polymorphism at codon 16 or 27. The mean degree of desensitization for bronchoprotection was comparable with all four treatments and there were no significant differences in absolute PD20 values after 2 weeks of chronic dosing. The PD20 values were (as microg of methacholine, geometric means+/-S. E.M.): formoterol, 12 microg once daily, 99+/-42 microg; formoterol, 6 microg twice daily, 107+/-44 microg; formoterol, 24 microg twice daily, 108+/-45 microg; terbutaline, 500 microg four times daily, 88+/-37 microg. All patients receiving formoterol, 24 microg twice daily, exhibited a loss of protection greater than 30% which was unrelated to polymorphism at codon 16 or 27. For codon 16, the use of lower doses of formoterol (12 microg once daily or 6 microg twice daily) showed wider variability in the propensity for protection loss in patients who were heterozygous, in contrast to a more uniform protection loss seen with homozygous glycine patients. The amount of protection loss was not significantly related to polymorphism at codon 16 or 27, expressed as values (mean+/-S.E.M.) for percentage desensitization according to each genotype (pooled treatments): Gly-16, 66+/-11%; Het-16, 53+/-8%; Arg-16, 69+/-18%; Glu-27, 68+/-12%; Het-27, 58+/-8%; Gln-27, 52+/-12%. The results of this preliminary study showed that bronchoprotective desensitization occurred readily in response to short- or long-acting beta2-agonist exposure irrespective of beta2-adrenoceptor polymorphism at codon 16 or 27. Further studies with larger patient numbers are required to further evaluate the effects of polymorphisms with lower doses of regular formoterol.  (+info)

Effects of tumour necrosis factor-alpha on left ventricular function in the rat isolated perfused heart: possible mechanisms for a decline in cardiac function. (5/1992)

1. The cardiac depressant actions of TNF were investigated in the isolated perfused rat heart under constant flow (10 ml min(-1)) and constant pressure (70 mmHg) conditions, using a recirculating (50 ml) mode of perfusion. 2. Under constant flow conditions TNF (20 ng ml(-1)) caused an early (< 25 min) decrease in left ventricular developed pressure (LVDP), which was maintained for 90 min (LVDP after 90 min: control vs TNF; 110 +/- 4 vs 82 +/- 10 mmHg, P < 0.01). 3. The depression in cardiac function seen with TNF under constant flow conditions, was blocked by the ceramidase inhibitor N-oleoylethanolamine (NOE), 1 microM, (LVDP after 90 min: TNF vs TNF with NOE; 82 +/- 10 vs 11 +/- 5 mmHg, P < 0.05). 4. In hearts perfused at constant pressure, TNF caused a decrease in coronary flow rate (change in flow 20 min after TNF: control vs TNF; -3.0 +/- 0.9 vs -8.7 +/- 1.2 ml min(-1), P < 0.01). This was paralleled by a negative inotropic effect (change in LVDP 20 min after TNF: control vs TNF; -17 +/- 7 vs -46 +/- 6 mmHg, P < 0.01). The decline in function was more rapid and more severe than that seen under conditions of constant flow. 5. These data indicate that cardiac function can be disrupted by TNF on two levels, firstly via a direct, ceramidase dependant negative inotropic effect, and secondly via an indirect coronary vasoconstriction.  (+info)

MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast. (6/1992)

Glycosylphosphatidylinositol (GPI)-anchored proteins are cell surface-localized proteins that serve many important cellular functions. The pathway mediating synthesis and attachment of the GPI anchor to these proteins in eukaryotic cells is complex, highly conserved, and plays a critical role in the proper targeting, transport, and function of all GPI-anchored protein family members. In this article, we demonstrate that MCD4, an essential gene that was initially identified in a genetic screen to isolate Saccharomyces cerevisiae mutants defective for bud emergence, encodes a previously unidentified component of the GPI anchor synthesis pathway. Mcd4p is a multimembrane-spanning protein that localizes to the endoplasmic reticulum (ER) and contains a large NH2-terminal ER lumenal domain. We have also cloned the human MCD4 gene and found that Mcd4p is both highly conserved throughout eukaryotes and has two yeast homologues. Mcd4p's lumenal domain contains three conserved motifs found in mammalian phosphodiesterases and nucleotide pyrophosphases; notably, the temperature-conditional MCD4 allele used for our studies (mcd4-174) harbors a single amino acid change in motif 2. The mcd4-174 mutant (1) is defective in ER-to-Golgi transport of GPI-anchored proteins (i.e., Gas1p) while other proteins (i.e., CPY) are unaffected; (2) secretes and releases (potentially up-regulated cell wall) proteins into the medium, suggesting a defect in cell wall integrity; and (3) exhibits marked morphological defects, most notably the accumulation of distorted, ER- and vesicle-like membranes. mcd4-174 cells synthesize all classes of inositolphosphoceramides, indicating that the GPI protein transport block is not due to deficient ceramide synthesis. However, mcd4-174 cells have a severe defect in incorporation of [3H]inositol into proteins and accumulate several previously uncharacterized [3H]inositol-labeled lipids whose properties are consistent with their being GPI precursors. Together, these studies demonstrate that MCD4 encodes a new, conserved component of the GPI anchor synthesis pathway and highlight the intimate connections between GPI anchoring, bud emergence, cell wall function, and feedback mechanisms likely to be involved in regulating each of these essential processes. A putative role for Mcd4p as participating in the modification of GPI anchors with side chain phosphoethanolamine is also discussed.  (+info)

Effects of beta2-adrenergic stimulation on single-channel gating of rat cardiac L-type Ca2+ channels. (7/1992)

Cardiac L-type Ca2+ channels can be stimulated by activation of beta2-adrenoceptors. We intended to determine how the gating behavior at the single-channel level (cell-attached configuration) is affected after selective stimulation of beta2-adrenoceptors. Rat cardiomyocytes were exposed to zinterol, a beta2-agonist (n = 7), isoproterenol (n = 6), a nonselective agonist, 8-bromo-cAMP (n = 6), and a combination of isoproterenol and ICI-118551 (n = 8), a selective beta2-receptor antagonist, or isoproterenol and CGP-20712A, a beta1-selective antagonist (n = 7). In all groups the ensemble-average current and the availability of the channels to open on depolarization were increased in a similar fashion. In addition, the open probability (Po) within active sweeps was elevated. However, zinterol exerted this effect in a unique manner. It elevated Po not by shortening closed times but solely by reducing active sweeps with very low Po and a short burst duration. All zinterol effects were abolished by ICI-118551 (n = 5) and mimicked by isoproterenol plus CGP-20712A (n = 7). We conclude that beta2-adrenoceptor activation of L-type channels differs qualitatively from the classical cAMP-dependent mechanism.  (+info)

A randomized, double-blind, comparative trial of a new oral combination of artemether and benflumetol (CGP 56697) with mefloquine in the treatment of acute Plasmodium falciparum malaria in Thailand. (8/1992)

CGP 56697, a new oral fixed combination of artemether and benflumetol, was tested in a double-blinded, randomized trial in 252 adult patients treated either with CGP 56697 (4 x 4 tablets each containing 20 mg of artemether and 120 mg of benflumetol, given at 0, 8, 24, and 48 hr), or with mefloquine (three tablets of 250 mg at initial diagnosis, followed by two tablets of 250 mg at 8 hr). Baseline data of the two groups were comparable. The 28-day cure rate with CGP 56697 was lower than with mefloquine (69.3% versus 82.4%; P = 0.002). However, CGP 56697 was more effective than mefloquine in parasite clearance time (43 hr versus 66 hr; P < 0.001) fever clearance time (32 hr versus 54 hr; P < 0.005), and gametocyte clearance time (152 hr versus 331 hr; P < 0.001). This study revealed that CGP 56697 is effective against multidrug-resistant Plasmodium falciparum malaria in Thailand, but higher doses will probably be needed to improve the cure rate.  (+info)

Deanol, also known as dimethylaminoethanol or DMAE, is a naturally occurring compound that is found in small amounts in certain foods, such as anchovies and sardines. It is also available as a dietary supplement. Deanol is a precursor to choline, which is a nutrient that is essential for the synthesis of the neurotransmitter acetylcholine.

Deanol has been studied for its potential effects on various aspects of mental and physical health. Some proponents of deanol claim that it can improve memory, concentration, and intelligence, as well as reduce symptoms of attention deficit hyperactivity disorder (ADHD) and Alzheimer's disease. However, there is limited scientific evidence to support these claims, and more research is needed to confirm the potential benefits of deanol.

It is important to note that deanol can have side effects, including headache, dizziness, insomnia, and increased blood pressure. It may also interact with certain medications, so it is important to speak with a healthcare provider before taking deanol or any other dietary supplement.

Ethanolamines are a class of organic compounds that contain an amino group (-NH2) and a hydroxyl group (-OH) attached to a carbon atom. They are derivatives of ammonia (NH3) in which one or two hydrogen atoms have been replaced by a ethanol group (-CH2CH2OH).

The most common ethanolamines are:

* Monethanolamine (MEA), also called 2-aminoethanol, with the formula HOCH2CH2NH2.
* Diethanolamine (DEA), also called 2,2'-iminobisethanol, with the formula HOCH2CH2NHCH2CH2OH.
* Triethanolamine (TEA), also called 2,2',2''-nitrilotrisethanol, with the formula N(CH2CH2OH)3.

Ethanolamines are used in a wide range of industrial and consumer products, including as solvents, emulsifiers, detergents, pharmaceuticals, and personal care products. They also have applications as intermediates in the synthesis of other chemicals. In the body, ethanolamines play important roles in various biological processes, such as neurotransmission and cell signaling.

Amino alcohols are organic compounds containing both amine and hydroxyl (alcohol) functional groups. They have the general structure R-NH-OH, where R represents a carbon-containing group. Amino alcohols can be primary, secondary, or tertiary, depending on the number of alkyl or aryl groups attached to the nitrogen atom.

These compounds are important in many chemical and biological processes. For example, some amino alcohols serve as intermediates in the synthesis of pharmaceuticals, dyes, and polymers. In biochemistry, certain amino alcohols function as neurotransmitters or components of lipids.

Some common examples of amino alcohols include:

* Ethanolamine (monoethanolamine, MEA): a primary amino alcohol used in the production of detergents, emulsifiers, and pharmaceuticals
* Serinol: a primary amino alcohol that occurs naturally in some foods and is used as a flavoring agent
* Choline: a quaternary ammonium compound with a hydroxyl group, essential for human nutrition and found in various foods such as eggs, liver, and peanuts
* Trimethylamine (TMA): a tertiary amino alcohol that occurs naturally in some marine animals and is responsible for the "fishy" odor of their flesh.

Ethanolamine is an organic compound that is a primary amine and a secondary alcohol. It is a colorless, viscous liquid with an odor similar to ammonia. Ethanolamine is used in the manufacture of a wide variety of products including detergents, pharmaceuticals, polishes, inks, textiles, and plastics. In the body, ethanolamine is a component of many important molecules, such as phosphatidylethanolamine, which is a major constituent of cell membranes. It is also involved in the synthesis of neurotransmitters and hormones.

... is a colorless, viscous liquid with an odor reminiscent of ammonia. Ethanolamine is commonly called ... Ethanolamine is biosynthesized by decarboxylation of serine: HOCH 2CH(CO 2H)NH 2 → HOCH 2CH 2NH 2 + CO2 Derivatives of ... Ethanolamine is often used for alkalinization of water in steam cycles of power plants, including nuclear power plants with ... For example, reacting ethanolamine with ammonia gives ethylenediamine, a precursor of the commonly used chelating agent, EDTA. ...
In enzymology, an ethanolamine kinase (EC 2.7.1.82) is an enzyme that catalyzes the chemical reaction ATP + ethanolamine ⇌ {\ ... Other names in common use include ethanolamine kinase (phosphorylating), and ethanolamine phosphokinase. This enzyme ... Sung CP, Johnstone RM (1967). "Phosphorylation of choline and ethanolamine in Ehrlich ascites-carcinoma cells". Biochem. J. 105 ... Weinhold PA, Rethy VB (1972). "Ethanolamine phosphokinase: activity and properties during liver development" (PDF). Biochim. ...
In enzymology, an ethanolamine oxidase (EC 1.4.3.8) is an enzyme that catalyzes the chemical reaction ethanolamine + H2O + O2 ... Narrod SA, Jakoby WB (1964). "Metabolism of ethanolamine. An ethanolamine oxidase". J. Biol. Chem. 239: 2189-2193. doi:10.1016/ ... The systematic name of this enzyme class is ethanolamine:oxygen oxidoreductase (deaminating). It has 2 cofactors: cobalt, and ... displaystyle \rightleftharpoons } glycolaldehyde + NH3 + H2O2 The 3 substrates of this enzyme are ethanolamine, H2O, and O2, ...
The enzyme ethanolamine ammonia-lyase (EC 4.3.1.7) catalyzes the chemical reaction ethanolamine ⇌ {\displaystyle \ ... The systematic name of this enzyme class is ethanolamine ammonia-lyase (acetaldehyde-forming). It is also called ethanolamine ... II Requirement for a cobamide coenzyme by an ethanolamine deaminase". J. Biol. Chem. 240 (12): 4675-81. doi:10.1016/S0021-9258( ... Bradbeer C (1965). "The clostridial fermentations of choline and ethanolamine. 1 Preparation and properties of cell-free ...
... (EOS) is an ester of sulfuric acid and ethanolamine. EOS is a GABA transaminase inhibitor which prevents ... "Anticonvulsant action of ethanolamine-O-sulfate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice ... "Ethanolamine-O-sulfate enhances gamma-aminobutyric acid secretion into hypophysial portal blood and lowers serum prolactin ...
CDP-ethanolamine Thus, the two substrates of this enzyme are CTP and ethanolamine phosphate, whereas its two products are ... "2-Aminoethylarsonic acid as an analogue of ethanolamine phosphate Endowment of ethanolamine-phosphate cytidylyltransferase with ... In enzymology, an ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) is an enzyme that catalyzes the chemical reaction ... ethanolamine-phosphate cytidylyltransferase. Other names in common use include phosphorylethanolamine transferase, ET, CTP- ...
The enzyme ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) catalyzes the chemical reaction ethanolamine phosphate + H2O ⇌ {\ ... Metabolism of ethanolamine and 1-aminopropan-2-ol in species of Erwinia and the roles of amino alcohol kinase and amino alcohol ... The systematic name of this enzyme class is ethanolamine-phosphate phosphate-lyase (deaminating; acetaldehyde-forming). Other ... and ethanolamine-phosphate phospho-lyase (deaminating). It employs one cofactor, pyridoxal phosphate. Fleshood HL, Pitot HC ( ...
... ethanolamine Thus, the two substrates of this enzyme are N-(long-chain-acyl)ethanolamine and H2O, whereas its two products are ... In enzymology, a N-(long-chain-acyl)ethanolamine deacylase (EC 3.5.1.60) is an enzyme that catalyzes the chemical reaction N-( ... The systematic name of this enzyme class is N-(long-chain-acyl)ethanolamine amidohydrolase. Other names in common use include N ... long-chain-acyl)ethanolamine + H2O ⇌ {\displaystyle \rightleftharpoons } a long-chain carboxylate + ...
Matthias Frauenkron; Johann-Peter Melder; Günther Ruider; Roland Rossbacher; Hartmut Höke (2002). "Ethanolamines and ...
"Ethanolamines and Propanolamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007. ...
Frauenkron, Matthias; Melder, Johann-Peter; Ruider, Günther; Rossbacher, Roland; Höke, Hartmut (2001). "Ethanolamines and ...
The compound, which is chiral, is an example of a 1,2-ethanolamine. tyrosol, HOC6H4CH2CH2OH Phoon, Chee Wee; Abell, Chris (1998 ... "Ethanolamines and Propanolamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007. ...
... s methanolamine, from the reaction of ammonia with formaldehyde Ethanolamine 2-amino-2-methyl-1-propanol is a ... Isoetarine is yet another medicinally useful derivative of ethanolamine. Heptaminol, a cardiac stimulant Propanolamines Most ... Examples include prolinol (from proline), valinol (from valine), tyrosinol (from tyrosine). Key members: ethanolamine, ... "Ethanolamines and Propanolamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007. ...
Frauenkron, Matthias; Melder, Johann-Peter; Ruider, Günther; Rossbacher, Roland; Höke, Hartmut (2001). "Ethanolamines and ...
"Ethanolamines and Propanolamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007. ... Lessmann, H.; Uter, W.; Schnuch, A.; Geier, J. (2009). "Skin sensitizing properties of the ethanolamines mono-, di-, and ... Triethanolamine is produced from the reaction of ethylene oxide with aqueous ammonia, also produced are ethanolamine and ... Complexometric titration Ethanolamine Ethanol Triethanolamine salicylate "Front Matter". Nomenclature of Organic Chemistry : ...
Choline Diphenhydramine Doxylamine Ethanolamine Meclofenoxate (Centrophenoxine) Orphenadrine Littel, RJ; Bos, M; Knoop, GJ ( ... Matthias Frauenkron; Johann-Peter Melder; Günther Ruider; Roland Rossbacher; Hartmut Höke (2002). "Ethanolamines and ...
Ethanolamine is not indicated for the treatment of patients with esophageal varices that have not bled. There is no evidence ... Sclerotherapy with ethanolamine has no beneficial effect upon portal hypertension, the cause of esophageal varices, so that ... "Ethanolamine Oleate". RXList. Retrieved 7 March 2020. v t e (Articles with short description, Short description matches ...
"Syntheses from Ethanolamine. V. Synthesis of Δ2-Oxazoline and of 2,2'-Δ2-Dioxazoline". Journal of the American Chemical Society ...
Ethanolamines are used in the manufacture of soap and detergents and for purification of natural gas. Ethoxylates are reaction ... Other important products include ethylene glycol ethers, ethanolamines and ethoxylates. Among glycols, ethylene glycol is used ... ISBN 0-8247-2470-4. "Technology of ethanolamine". Technology. Himtek Engineering. Archived from the original on 2 March 2005. ... ethanolamines. The reaction is stimulated by adding a small amount of water. (CH2CH2)O + NH3 → HO-CH2CH2-NH2 2 (CH2CH2)O + NH3 ...
N-Docosahexaenoyl ethanolamine (DHEA: C24H37NO2; 22:6, ω-3), or Anandamide (22:6, n-3) "synaptamide", is the non-oxidative ... The hydrolysis of NAE to free fatty acid (FFA) and ethanolamine (MEA) in animals, is catalyzed by fatty acid amide hydrolase ( ... NAE 20:4 (AEA: C22H37NO2; 20:4, ω-6) is the amide of arachidonic acid (C20H32O2; 20:4, ω-6) and ethanolamine (MEA: C2H7NO). NAE ... N-Palmitoylethanolamine (PEA: C18H37NO2; 16:0) is the amide of palmitic acid (C16H32O2; 16:0) and ethanolamine. It is a ligand ...
O-Arachidonoyl ethanolamine is arachidonic acid and ethanolamine joined by an ester linkage, the opposite of the amide linkage ... Virodhamine (O-arachidonoyl ethanolamine; O-AEA) is an endocannabinoid and a nonclassic eicosanoid, derived from arachidonic ...
Choline kinase beta (CK), also known as Ethanolamine kinase (EK), Choline kinase-like protein , choline/ethanolamine kinase ... However, it has been shown that the protein has higher activity with ethanolamine and may not significantly contribute to in ... "CHKB - Choline/ethanolamine kinase - Homo sapiens (Human) - CHKB gene & protein". Retrieved 2018-08-23. This article ... The choline kinase (CK) and ethanolamine kinase (EK) proteins, which are coded by the CHKB gene, catalyze the phosphorylation ...
This forms ethanolamine phosphate and hexadecenal. Sphingolipids are commonly believed to protect the cell surface against ... The sphingosine backbone is O-linked to a (usually) charged head group such as ethanolamine, serine, or choline.[citation ...
It has an advantage over a similar amine, ethanolamine, in that a higher concentration may be used for the same corrosion ... Matthias Frauenkron, Johann-Peter Melder, Günther Ruider, Roland Rossbacher, Hartmut Höke "Ethanolamines and Propanolamines" in ... The reaction of ethylene oxide with aqueous ammonia first produces ethanolamine: C2H4O + NH3 → H2NCH2CH2OH which reacts with a ... "Skin sensitizing properties of the ethanolamines mono-, di-, and triethanolamine. Data analysis of a multicentre surveillance ...
"Ethanolamine Compounds (MEA, DEA, TEA And Others)". Safe Cosmetics. Retrieved 2020-06-17. "tetraethylammonium , Ligand page , ...
The copper in the preparation is in the form of a soluble complex with ammonia NH3 or an amine such as ethanolamine N(C2H5)H2. ... The formulations with ethanolamine, especially ACQ-D, are generally used for easier woods (such as southern pine) because it ... Otherwise ethanolamine is preferred as copper carrier. Quaternary ammonium cations The quaternary ammonium cation in some ... Types registered in the US and Canada: ACQ-A: copper-ethanolamine (50% CuO equivalent), and DDA chloride (50%). ACQ-B: copper- ...
... phosphatidylethanolamine is also made via the cytidine diphosphate-ethanolamine pathway, using ethanolamine as the substrate. ... N-Acylphosphatidylethanolamine Phosphatidyl ethanolamine methyltransferase Wellner, Niels; Diep, Thi Ai; Janfelt, Christian; ... They are synthesized by the addition of cytidine diphosphate-ethanolamine to diglycerides, releasing cytidine monophosphate. S- ... Whereas the phosphate group is combined with choline in phosphatidylcholine, it is combined with ethanolamine in ...
The poly(methyl-ethanolamine) formed by further addition of ethylene oxide to methylethanolamine remains in the distillation ... Ltd.: Methyl Ethanolamines Technology Archived 2016-03-06 at the Wayback Machine (PDF; 152 kB). Product Safety Assessment, DOW ... Ethanolamine Dimethylethanolamine Merck Index, 12th Edition, 6096. Matthias Frauenkron, Johann-Peter Melder, Günther Ruider, ... where it is used together with its analogs ethanolamine and dimethylethanolamine. N-Methylethanolamine is produced industrially ...
It is degraded primarily by the fatty acid amide hydrolase (FAAH) enzyme, which converts anandamide into ethanolamine and ... Natarajan V, Reddy PV, Schmid PC, Schmid HH (August 1982). "N-Acylation of ethanolamine phospholipids in canine myocardium". ... which breaks it down into free arachidonic acid and ethanolamine. Studies of piglets show that dietary levels of arachidonic ...
Treatment with ethanolamine ends up making an aminoetylborinate. 2-Aminoethoxydiphenyl borate (2-APB) inhibits transient ...
Ethanolamine is a colorless, viscous liquid with an odor reminiscent of ammonia. Ethanolamine is commonly called ... Ethanolamine is biosynthesized by decarboxylation of serine: HOCH 2CH(CO 2H)NH 2 → HOCH 2CH 2NH 2 + CO2 Derivatives of ... Ethanolamine is often used for alkalinization of water in steam cycles of power plants, including nuclear power plants with ... For example, reacting ethanolamine with ammonia gives ethylenediamine, a precursor of the commonly used chelating agent, EDTA. ...
Ethanolamine Oleate - Last updated on December 12, 2022. All rights owned and reserved by Memorial Sloan Kettering Cancer ...
Despite this, NMDA did not reduce the amount of radioactive CDP-ethanolamine, indicating that inhibition of ethanolamine kinase ... This solvent does resolve ethanolamine and phosphoethanolamine but does not separate CDP-ethanolamine and ... and developed in two different solvents to resolve ethanolamine, phosphoethanolamine, CDP-ethanolamine, and ... This effect of NMDA is not followed by a decrease in radioactive CDP-ethanolamine. On the contrary, Figure 6C shows a small ...
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine ... Showing Protein GPI ethanolamine phosphate transferase 3 (HMDBP07329). IdentificationBiological propertiesGene properties ...
US-10285956-B2 chemical patent summary.
"Ethanolamines" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Ethanolamines" by people in UAMS Profiles by year, and whether ... Below are the most recent publications written about "Ethanolamines" by people in Profiles over the past ten years. ...
Ethanolamines Market By Product Type, By Application, and Region (North America, Europe, Asia Pacific, Latin America, Middle ...
BASF is increasing its European sales prices for ethanolamines (EOA) as follows: Monoethanolamine (MEOA): + 55 EUR/ mt ... Ethanolamines are high-class intermediates used in the manufacture of crop and wood protection agents, surfactants for ... With immediate effect, or as existing contracts permit, BASF is increasing its European sales prices for ethanolamines (EOA) as ... https://www.chemeurope.com/en/news/152708/basf-increases-prices-for-ethanolamines-in-europe.html ...
Reaction of Ethylene Glycol with Adenosylcobalamin-Dependent Ethanolamine Ammonia-Lyase () 2022-04-11 21:43:41 -0400. Press to ... Adenosylcobalamin (AdoCbl)-dependent ethanolamine ammonia lyase (EAL) is associated with gut microbe homeostasis and disease ... Reaction of Ethylene Glycol with Adenosylcobalamin-Dependent Ethanolamine Ammonia-Lyase Open Access. Guidry, Bryce (Spring 2022 ...
... the prices for Huntsman ethanolamines will increase by $0.05 per pound. Continue reading for additional details. ...
Ethanolamine (2-aminoethanol, Monoethanolamine, ETA, or MEA) is an organic chemical compound with the formula HOCH2CH2NH2 or ... Ethanol Amine. Ethanolamine (2-aminoethanol, monoethanolamine, ETA, or MEA) is an organic chemical compound with the formula ... Ethanolamine is a colorless, viscous liquid with an odor reminiscent of ammonia. ETA molecules are a component in the formation ...
ETHANOLAMINE is a base. Reacts with organic acids (acetic acid, acrylic acid), inorganic acids (hydrochloric acid, hydrofluoric ... Excerpt from NIOSH Pocket Guide for Ethanolamine. :. Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing ...
Arabidopsis CHOLINE/ETHANOLAMINE KINASE 1 (CEK1) is a primary choline kinase localized at the endoplasmic reticulum (ER) and ... The Choline/Ethanolamine Kinase Family in Arabidopsis: Essential Role of CEK4 in Phospholipid Biosynthesis and Embryo ... An ethanolamine kinase Eki1 affects radial growth and cell wall integrity in Trichoderma reesei. ... BUMPY STEM Is an Arabidopsis Choline/Ethanolamine Kinase Required for Normal Development and Chilling Responses. ...
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  • 2-5 ml of ethanolamine oleate can be injected into the mucosa just above the hemorrhoids to cause ulceration and mucosal fixation thus preventing hemorrhoids from descending out of the anal canal. (wikipedia.org)
  • Sixty-six patients with portal hypertension and esophageal varices due to liver cirrhosis were randomized to receive either 5% ethanolamine oleate (EO) or 5% EO plus 1% polidocanol (EOP) as a sclerosant for endoscopic injection sclerotherapy (EIS). (elsevierpure.com)
  • Eradication of esophageal varices was attained with an average of 4.7 and 4.3 sessions of endoscopic injection sclerotherapy in the ethanolamine oleate and polidocanol groups, respectively. (elsevierpure.com)
  • Data on one patient in the ethanolamine oleate group had to be excluded because he left the hospital after 2 sessions of endoscopic injection sclerotherapy. (elsevierpure.com)
  • Ab initio molecular orbital calculations are used to examine the mechanism of action of B12-dependent ethanolamine ammonia-lyase involving the conversion of 2-aminoethanol to acetaldehyde plus ammonia. (edu.au)
  • Case studies have revealed several agents that could be potentially responsible for cleaning-related asthma, such as chlorine and ammonia 8 , 10 , ethanolamines 4 , 11 , and quaternary ammonium compounds 12 . (ersjournals.com)
  • There are a number of chemicals in cleaning and disinfecting products that can cause or exacerbate asthma because of their sensitizing or irritant properties, including quaternary ammonium compounds, ethanolamines, chlorhexidine, glutaraldehyde, ortho-phthalaldehyde, hexachlorophene, and chloramine-T. (cdc.gov)
  • Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. (hmdb.ca)
  • Low levels are associated with hyperthyroidism, and with the rare condition of idiopathic hypophosphatasia associated with rickets and the excretion of excess phosphatidyl ethanolamine in the urine. (cdc.gov)
  • In contrast, NMDA strongly reduced the incorporation of [ 3 H]choline and [ 3 H]ethanolamine into their respective phospholipids. (jneurosci.org)
  • Ethanolamine is commonly called monoethanolamine or MEA in order to be distinguished from diethanolamine (DEA) and triethanolamine (TEA). (wikipedia.org)
  • Ethanolamine (2-aminoethanol, monoethanolamine, ETA, or MEA) is a naturally occurring organic chemical compound with the formula HOCH 2CH 2NH 2 or C 2H 7NO. (wikipedia.org)
  • Ethanolamine (2-aminoethanol, monoethanolamine, ETA, or MEA) is an organic chemical compound with the formula HOCH2CH2NH2 or C2H7NO. (atlaspetro.com)
  • The ethanolamines comprise a group of amino alcohols. (wikipedia.org)
  • ChEBI: 2-diethylaminoethanol is a member of the class of ethanolamines that is aminoethanol in which the hydrogens of the amino group are replaced by ethyl groups. (lookchem.com)
  • It is a member of ethanolamines, a tertiary amino compound and a primary alcohol. (lookchem.com)
  • Ethanolamines are high-class intermediates used in the manufacture of crop and wood protection agents, surfactants for detergents and cleaning products, process chemicals for gas treatment, lubricants and cement additives as well as active pharmaceutical ingredients. (chemeurope.com)
  • Metabolic labeling experiments in whole cells showed that NMDA receptor overactivation does not modify the activity of phosphocholine or phosphoethanolamine cytidylyltransferases but strongly inhibits choline-ethanolamine phosphotransferase activity. (jneurosci.org)
  • Link to all annotated objects annotated to ethanolamine metabolic process. (planteome.org)
  • Link to all direct and indirect annotations to ethanolamine metabolic process. (planteome.org)
  • Specifically, this enzyme adds a molecule of ethanolamine phosphate to the end of the forming GPI anchor. (medlineplus.gov)
  • citation needed] Upon reaction with carbon dioxide, 2 equivalents of ethanolamine react through the intermediacy of carbonic acid to form a carbamate salt, which when heated reforms ethanolamine and carbon dioxide. (wikipedia.org)
  • Finally, the solubilities of carbon dioxide and hydrogen sulfide in the aqueous ethanolamine solutions were predicted and compared to the experimental data. (elsevierpure.com)
  • NIOSH investigators returned to NTN Bower on June 20, 2005, and collected personal and area air samples for MWFs, carbon monoxide (CO), ethanolamines, PAHs, and formaldehyde. (cdc.gov)
  • We are a leading Wholesale Trader of tri ethanolamine tech, phosphoric acid 85, liquid glucose, tween 80 polysorbate 80, alta methyl salicylate and polyquaternium 7 surfactant from Delhi, India. (mayaindia.co.in)
  • Nasrifar, K & Tafazzol, AH 2010, ' Vapor-liquid equilibria of acid gas-aqueous ethanolamine solutions using the PC-SAFT equation of state ', Industrial and Engineering Chemistry Research , المجلد 49, رقم 16, الصفحات 7620-7630. (elsevierpure.com)
  • The PIGO gene provides instructions for making one part of an enzyme called GPI ethanolamine phosphate transfer 3 (GPI-ET3). (medlineplus.gov)
  • Members of the family of Phosphatidy Ethanolamine-Binding Protein (PEBP) have been shown to be key regulators of the transition of plants from vegetative to reproductive phases. (figshare.com)
  • The altered protein is less able to add ethanolamine phosphate to the end of GPI anchors. (medlineplus.gov)
  • Because ethanolamine is a newer chemical, it has not been evaluated for cancer risks yet. (lovemyhair.co.za)
  • But if you are going to use a chemical dye (that is not a Love My Hair Low Chemical dye - which don't contain ammonia or ethanolamine), rather use one that contains ammonia, and avoid ethanolamine like the plague. (lovemyhair.co.za)
  • The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). (planteome.org)
  • For example, reacting ethanolamine with ammonia gives ethylenediamine, a precursor of the commonly used chelating agent, EDTA. (wikipedia.org)
  • The Environmental Working Group website rates ethanolamine as 5-6, which is slightly worse than ammonia's rating of 4-6. (lovemyhair.co.za)
  • PC-SAFT accurately described the properties of the pure ethanolamines along the coexistence curve. (elsevierpure.com)
  • The results indicated that PC-SAFT successfully described the equilibrium properties of the aqueous ethanolamine solutions. (elsevierpure.com)
  • this process requires the ethanolamine phosphate at the end of the anchor. (medlineplus.gov)
  • This graph shows the total number of publications written about "Ethanolamines" by people in UAMS Profiles by year, and whether "Ethanolamines" was a major or minor topic of these publications. (uams.edu)
  • Ethanolamine has been shown to damage hair more than ammonia, in some extreme cases as much as 85% more. (lovemyhair.co.za)
  • And ethanolamine has been shown to cause more hair loss than ammonia. (lovemyhair.co.za)
  • Ethanolamine is a colorless, viscous liquid with an odor reminiscent of ammonia. (wikipedia.org)
  • Then, the vapor-liquid equilibria (VLE) of the aqueous ethanolamine solutions were calculated by temperature-independent binary interaction parameters. (elsevierpure.com)
  • We found that the antifungal agent ciclopirox ethanolamine (CPX) selectively supported immature CD34+CD90+ cells during culture and enhanced their long-term in vivo repopulation capacity. (lu.se)