An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.
An inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol has two hydroxyl groups, at 3-alpha and 20-alpha. It is detectable in URINE after OVULATION and is found in great quantities in the pregnancy urine.
An arylsulfatase with high specificity towards sulfated steroids. Defects in this enzyme are the cause of ICHTHYOSIS, X-LINKED.
Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.
Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.
A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
Enzymes that catalyze the oxidation of estradiol at the 17-hydroxyl group in the presence of NAD+ or NADP+ to yield estrone and NADH or NADPH. The 17-hydroxyl group can be in the alpha- or beta-configuration. EC 1.1.1.62
A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.
A subclass of ORGANIC ANION TRANSPORTERS that do not rely directly or indirectly upon sodium ion gradients for the transport of organic ions.
2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an estrogenic action or interaction with the catecholaminergic system.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.
A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
Proteins involved in the transport of organic anions. They play an important role in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body.
A metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.
The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.
The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.
A polyspecific transporter for organic cations found primarily in the kidney. It mediates the coupled exchange of alpha-ketoglutarate with organic ions such as P-AMINOHIPPURIC ACID.
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
Tumors or cancer of the human BREAST.
Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.
The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.
Enzymes that catalyze the hydrolysis of a phenol sulfate to yield a phenol and sulfate. Arylsulfatase A, B, and C have been separated. A deficiency of arylsulfatases is one of the causes of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.1.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
The surgical removal of one or both ovaries.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
Materials incorporated mechanically in plastics (usually PVC) to increase flexibility, workability or distensibility; due to the non-chemical inclusion, plasticizers leach out from the plastic and are found in body fluids and the general environment.
An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
Substances that are recognized by the immune system and induce an immune reaction.
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A genus of deer, Rangifer, that inhabits the northern parts of Europe, Asia, and America. Caribou is the North American name; reindeer, the European. They are often domesticated and used, especially in Lapland, for drawing sleds and as a source of food. Rangifer is the only genus of the deer family in which both sexes are antlered. Most caribou inhabit arctic tundra and surrounding arboreal coniferous forests and most have seasonal shifts in migration. They are hunted extensively for their meat, skin, antlers, and other parts. (From Webster, 3d ed; Walker's Mammals of the World, 5th ed, p1397)
A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

Lack of zonal uptake of estrone sulfate in enriched periportal and perivenous isolated rat hepatocytes. (1/928)

The zonal uptake of estrone sulfate (E1S; 1 to 400 microM) was investigated in periportal and perivenous rat hepatocytes and cells isolated from whole liver (regular hepatocytes). Transport of E1S by periportal, perivenous, and regular hepatocytes was described by saturable (Kms of 24 to 26 microM and Vmaxs of 1.8 nmol/min/mg protein) and nonsaturable components (2.5 to 3.2 microl/min/mg protein) that were not different among the zonal regions (p >.05, ANOVA). These kinetic constants represented pooled values for the entire complement of transporters for E1S, including two known transporters of E1S: Ntcp, Na+-taurocholate cotransporting polypeptide, and oatp1, the organic anion transporting polypeptide cloned from rat liver. Uptake of E1S was significantly reduced by estradiol 17beta-glucuronide (50 microM) and bumetanide (200 microM), and was inhibited strongly and competitively by pregnenolone sulfate with an inhibition constant of 6.7 microM. Further segregation of the kinetic constants as the sodium-dependent and -independent systems was achieved through simultaneous fitting of data obtained in the presence and absence of sodium from parallel hepatocytic uptake studies. For the periportal, perivenous, and regular hepatocytes, two saturable systems: a sodium-dependent transport system, characterized by similar Vmaxs (1.1 to 1.4 nmol/min/mg protein) and Kms (49 to 55 microM), a sodium-independent transport system of comparable Vmaxs (0.70 to 0.84 nmol/min/mg protein) and Kms (16 to 22 microM), and a linear clearance of 1.7 to 2.7 microl/min/mg protein (ANOVA, p >.05) were obtained. The data suggest that hepatic uptake of E1S involved sodium-dependent and -independent transporter systems. No heterogeneity in transport was observed.  (+info)

Laboratory assay reproducibility of serum estrogens in umbilical cord blood samples. (2/928)

We evaluated the reproducibility of laboratory assays for umbilical cord blood estrogen levels and its implications on sample size estimation. Specifically, we examined correlation between duplicate measurements of the same blood samples and estimated the relative contribution of variability due to study subject and assay batch to the overall variation in measured hormone levels. Cord blood was collected from a total of 25 female babies (15 Caucasian and 10 Chinese-American) from full-term deliveries at two study sites between March and December 1997. Two serum aliquots per blood sample were assayed, either at the same time or 4 months apart, for estrone, total estradiol, weakly bound estradiol, and sex hormone-binding globulin (SHBG). Correlation coefficients (Pearson's r) between duplicate measurements were calculated. We also estimated the components of variance for each hormone or protein associated with variation among subjects and variation between assay batches. Pearson's correlation coefficients were >0.90 for all of the compounds except for total estradiol when all of the subjects were included. The intraclass correlation coefficient, defined as a proportion of the total variance due to between-subject variation, for estrone, total estradiol, weakly bound estradiol, and SHBG were 92, 80, 85, and 97%, respectively. The magnitude of measurement error found in this study would increase the sample size required for detecting a difference between two populations for total estradiol and SHBG by 25 and 3%, respectively.  (+info)

Estrogens induce apoptosis in mouse peritoneal macrophages. (3/928)

AIM: To study whether estrogen might induce apoptosis in mouse peritoneal macrophages (MPM). METHOD: The MPM were isolated and incubated in culture medium containing 17-beta-estradiol, estrone, or equal volume of 100% ethanol as control. DNA fragmentation was visualized by agarose gel electrophoresis. RESULTS: 17-beta-Estradiol 0.01-1 mumol.L-1 or estrone 10-20 mumol.L-1 elicited typical morphological apoptosis and DNA fragmentation in a concentration-dependent manner in MPM. Staurosporine (Sta) 0.01 mumol.L-1, cycloheximide (Cyc) 1 mg.L-1, and tamoxifen (Tam) 10 mumol.L-1 inhibited the DNA fragmentation induced by 17-beta-estradiol 1 mumol.L-1 or estrone 20 mumol.L-1. CONCLUSION: Estradiol and estrone induced apoptosis in MPM.  (+info)

Caffeine consumption and menstrual function. (4/928)

The relation between caffeine intake and menstrual function was examined in 403 healthy premenopausal women who belonged to Kaiser Permanente Medical Care Program in 1990-1991. A telephone interview collected information about caffeinated beverage intake as well as other lifestyle, demographic, occupational, and environmental factors. Subjects collected daily urine samples and completed a daily diary for an average of five menstrual cycles. Metabolites of estrogen and progesterone were measured in the urine, each cycle was characterized as anovulatory or ovulatory, and a probable day of ovulation was selected when appropriate. Logistic regression and repeated measures analyses were performed on menstrual parameters. Women whose caffeine consumption was heavy (>300 mg of caffeine per day) had less than a third of the risk for long menses (> or =8 days) compared with women who did not consume caffeine (adjusted odds ratio = 0.30, 95% confidence interval 0.14-0.66). Those whose caffeine consumption was heavy also had a doubled risk for short cycle length (< or =24 days) (adjusted odds ratio = 2.00, 95% confidence interval 0.98-4.06); this association was also evident in those whose caffeine consumption was heavy who did not smoke (adjusted odds ratio = 2.11, 95% confidence interval 1.03-4.33). Caffeine intake was not strongly related to an increased risk for anovulation, short luteal phase (< or =10 days), long follicular phase (> or =24 days), long cycle (> or =36 days), or measures of within-woman cycle variability.  (+info)

Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. (5/928)

The rat liver organic anion transporting polypeptide (Oatp1) has been extensively characterized mainly in the Xenopus laevis expression system as a polyspecific carrier transporting organic anions (bile salts), neutral compounds, and even organic cations. In this study, we extended this characterization using a mammalian expression system and confirm the basolateral hepatic expression of Oatp1 with a new antibody. Besides sulfobromophthalein [Michaelis-Menten constant (Km) of approximately 3 microM], taurocholate (Km of approximately 32 microM), and estradiol- 17beta-glucuronide (Km of approximately 4 microM), substrates previously shown to be transported by Oatp1 in transfected HeLa cells, we determined the kinetic parameters for cholate (Km of approximately 54 microM), glycocholate (Km of approximately 54 microM), estrone-3-sulfate (Km of approximately 11 microM), CRC-220 (Km of approximately 57 microM), ouabain (Km of approximately 3,000 microM), and ochratoxin A (Km of approximately 29 microM) in stably transfected Chinese hamster ovary (CHO) cells. In addition, three new substrates, taurochenodeoxycholate (Km of approximately 7 microM), tauroursodeoxycholate (Km of approximately 13 microM), and dehydroepiandrosterone sulfate (Km of approximately 5 microM), were also investigated. The results establish the polyspecific nature of Oatp1 in a mammalian expression system and definitely identify conjugated dihydroxy bile salts and steroid conjugates as high-affinity endogenous substrates of Oatp1.  (+info)

Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. (6/928)

A cDNA encoding the new member of the multispecific organic anion transporter family, OAT3, was isolated by the reverse transcription-polymerase chain reaction cloning method. Degenerate primers were designed based on the sequences conserved among OAT1, OAT2, and organic cation transporter 1 (OCT1), and reverse transcription-polymerase chain reaction was performed using rat brain poly(A)+ RNA. The 536-amino acid protein sequence encoded by OAT3 showed 49, 39, and 36% identity to those of OAT1, OAT2, and OCT1, respectively. Northern blot analysis revealed that rat OAT3 mRNA is expressed in the liver, brain, kidney, and eye. When expressed in Xenopus laevis oocytes, OAT3 mediated the uptake of organic anions, such as p-aminohippurate (Km = 65 microM), ochratoxin A (Km = 0.74 microM), and estrone sulfate (Km = 2.3 microM) and a cationic compound, cimetidine. OAT3-mediated uptake of [3H]estrone sulfate was sodium-independent. para-Aminohippuric acid, estrone sulfate or ochratoxin A did not show any trans-stimulatory effect on either influx or efflux of [3H]estrone sulfate via OAT3. Organic anions such as sulfobromophthalein, probenecid, indocyanine green, bumetanide, piroxicam, furosemide, azidodeoxythymidine, 4, 4'-diisothiocyanostilbene-3,3'-disulfonic acid, and benzylpenicillin inhibited OAT3-mediated estrone sulfate uptake, while ouabain and digoxin did not. Organic cations such as tetraethylammonium, guanidine, verapamil, and quinidine did not interact with OAT3. Acidic metabolites of neurotransmitters derived from dopamine, epinephrine, norepinephrine, and serotonin inhibited the uptake of estrone sulfate via OAT3. These results suggest an important role of OAT3 in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain.  (+info)

Reproducibility and validity of radioimmunoassays for urinary hormones and metabolites in pre- and postmenopausal women. (7/928)

The reproducibility of RIAs of circulating sex hormones has been evaluated as part of recent epidemiological investigations, but none seem to have addressed the reproducibility or validity of RIAs for urinary hormones or their metabolites. As part of a case-control study of breast cancer in Asian-American women, 12-h overnight urine samples were obtained, and a methodological study was conducted to identify laboratories capable of assaying urinary hormones. For the reproducibility component of this study, two laboratories with extensive experience in hormone assays measured urinary estrone, estradiol, estriol, pregnanediol glucuronide, and estrone glucuronide using samples from 15 women (5 midfollicular, 5 midluteal, and 5 postmenopausal). Variance estimates from these measurements were used to calculate the laboratory variability (coefficient of variation) and to assess the magnitude of the biological variability among the women in relation to the total variability (intraclass correlation coefficient). For the validity component, urinary estrone, estradiol, and estriol levels were measured in the same samples by gas chromatography-mass spectroscopy in the laboratory of Dr. Herman Adlercreutz (University of Helsinki, Helsinki, Finland). We found that the degree of assay reproducibility differed between the laboratories, but that laboratory variability was usually low compared with the range of hormone values among women, particularly for the estrogens. Values for estrone and estradiol were well correlated among all of the laboratories. For estriol, the RIAs tended to overestimate levels compared with gas chromatography-mass spectroscopy. In one laboratory, assays for pregnanediol glucuronide and estrone glucuronide were consistently reproduced; in the other, the reproducibility of the RIA for pregnanediol glucuronide was problematic, and estrone glucuronide was not measured. Despite some limitations, urinary hormones and their metabolites can be reliably measured by current RIAs in large investigations attempting to link hormone level to disease risk and may be particularly advantageous for studies of postmenopausal women, where serum concentrations of estrone and estradiol are low and assay measurements are not as dependable.  (+info)

Fecal estrone sulfate profile in sows during gestation. (8/928)

The aim of this study was to establish radioimmunoassay (RIA) for fecal estrone sulfate (E1S) and to elucidate changes in fecal E1S during pregnancy in the sow. Fecal E1S was extracted on a commercially available solid phase column, and the E1S fraction obtained was subjected to RIA. The sensitivity of the RIA was 8.5 pg/tube. The intra- and inter-assay coefficients of variation were 8.8-8.9% and 10.7-14.2%, respectively. Mean recovery for E1S added to fecal samples was as high as 95.0%. A significant positive correlation (r = 0.904, n = 147 p < 0.0001) existed between fecal and plasma E1S concentrations. Mean E1S concentration in feces and plasma fluctuated exhibiting two peaks. The first peak of E1S concentration was evident on day 28-32 in feces and on days 26-30 in plasma. The E1S concentration in both feces and plasma remained at baseline levels during mid-pregnancy, but began to rise gradually around days 72-82 and 70-80, in feces and plasma respectively, and reached a peak concentration on days 110-114. Following parturition, the concentration of E1S in plasma declined rapidly, but there was a two-day delay before a decline in fecal E1S. Apart from this two-day delay, changes in fecal E1S were similar to those in plasma E1S. The study indicates that the measurement of E1S in feces could be a useful tool for early pregnancy diagnosis and for monitoring fetal development in sows and gilts.  (+info)

TY - JOUR. T1 - DIURNAL CHANGES IN MATERNAL PLASMA ESTRONE AND ESTRADIOL AT 30 TO 31, 34 TO 35 AND 38 TO 39 WEEKS GESTATIONAL-AGE. AU - Challis, John. AU - Patrick, JE. AU - Campbell, K. AU - Natale, R. AU - Richardson, B. PY - 1980. Y1 - 1980. U2 - 10.1111/j.1471-0528.1980.tb04462.x. DO - 10.1111/j.1471-0528.1980.tb04462.x. M3 - Article. VL - 87. SP - 983. EP - 988. JO - BJOG: an International Journal of Obstetrics and Gynecology. JF - BJOG: an International Journal of Obstetrics and Gynecology. SN - 1470-0328. IS - 11. ER - ...
These results are consistent with previously published studies indicating an important role for CYP1A2 in the liver (31, 35, 36). Again, we observed higher velocities and lower apparent Km values than previously reported. The extent of the contribution by CYP2C19 to 2-hydroxylation of estrone has been overlooked in previous studies, either as a result of not examining the recombinant enzyme or as a result of comparing activities at high substrate concentrations.. Based on the results from the recombinant enzymes, one would predict that CYP1A2 would be the major contributor at low estrone concentrations to 4-hydroxylation of estrone, but that CYP3A4/5 (see Table 3) could contribute as estrone concentrations increased. Only the CYP2C9 marker activity correlated with 4-hydroxylation of 25 μmol/L estrone in human hepatic microsomes. However, the lack of correlation with CYP1A2 marker activities may reflect the contribution of multiple enzymes at this high substrate concentration, as furafylline and ...
Circulating levels (mean +/- SD) of estrone sulfate (E1S), estrone (E1) and estradiol-17 beta (E2) were measured in normal and cirrhotic postmenopausal women matched for body weight and age. In cirrhotic postmenopausal women, the E1S concentrations (201 +/- 46 pg/ml), while both E1 and E2 levels sho …
Vincze B, Kapuvari B, Udvarhelyi N, Horvath Z, Matrai Z, Czeyda-Pommersheim F, Kohalmy K, Kovacs J, Boldizsar M, Lang I, Kasler M: Serum estrone concentration, estrone sulfate/estrone ratio and BMI are associated with human epidermal growth factor receptor 2 and progesterone receptor status in postmenopausal primary breast cancer patients suffering invasive ductal carcinoma., SPRINGERPLUS 4: p. 387 ...
TY - JOUR. T1 - Endocrine profile in a patient with familial breast cancer. A case-control study. AU - Lynch, Henry T.. AU - Harris, R. E.. AU - Fishman, J.. AU - Lynch, J. F.. AU - Marrero, K.. AU - Maloney, K.. PY - 1979. Y1 - 1979. N2 - Urinary and blood hormonal profiles were studied throughout a monthly cycle in a patient with familial breast cancer. Two comparison cohorts (one high-risk and one low-risk) were studied concurrently. Findings disclosed that our breast cancer-affected patient showed a distinctive hormonal pattern characterized by significant elevation throughout the cycle of plasma estrone, estradiol, and prolactin. Save for a depression in plasma FSH in the early follicular phase, this hormone, as well as LH and progesterone patterns in our patient, were similar to the comparison cohorts. Urinary estrone and estradiol patterns in our patient were elevated early in the follicular phase. Our patient also showed a depression in urinary estrone, estradiol, and estriol following ...
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Literature References: A metabolite of 17b-estradiol, q.v., possessing considerably less biological activity; isolated as d-form. Occurs in pregnancy urine of women and mares, in follicular liquor of many animals, in human placenta, in urine of bulls and stallions, in palm-kernel oil. Isoln: Butenandt, Naturwissenschaften 17, 879 (1929); Doisy et al., Am. J. Physiol. 90, 329 (1929). Also isolated from moghat roots and date palm pollen grains: Amin et al., Phytochemistry 8, 295 (1969). Manuf: E. A. Doisy et al., US 1967350, US 1967351 (1934 both to St. Louis University); Joly et al., FR 1305992 (1962 to Roussel-Uclaf). Synthesis of a stereoisomer of estrone: W. E. Bachmann et al., J. Am. Chem. Soc. 64, 974 (1942). Total synthesis of natural estrone: G. Anner, K. Miescher, Helv. Chim. Acta 31, 2173 (1948); 32, 1957 (1949); 33, 1379 (1950); W. S. Johnson et al., J. Am. Chem. Soc. 72, 1426 (1950); 74, 2832 (1952); I. V. Torgov et al., Dokl. Akad. Nauk SSSR 135, 73 (1960), C.A. 55, 11462f (1961). ...
Estrone EIA Reproductive Markers 011-CAN-E-420,The procedure follows the basic principle of a competitive enzyme immunoassay where there is competition between an unlabeled antigen and an labelled antigen bound to the limited binding sites of a specific antiserum . The amount of enzyme conjugate complex (HRP-avidin: biotin-labelled estrone) bou,medicine,medical supply,medical supplies,medical product
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Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to treat abnormalities related to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar atrophy associated with menopause, and for the prevention of osteoporosis due to estrogen deficiency ...
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Progestogel action mechanism is based on increasing concentrations of progesterone in the tissues of the breast. Progesterone reduces the expression of estrogen receptors in breast tissue and also reduces the local level of active estrogens by stimulating the production of enzymes (17-beta-hydroxysteroid dehydrogenase and estronsulfotransferazy) oxidizing estradiol less active estrone (linking the latter, enzymes convert it into an inactive estrone sulfate). ...
BioAssay record AID 682056 submitted by ChEMBL: TP_TRANSPORTER: uptake (pH 5.0) of Estrone-3-sulfate at a concentration of 5.43 nM in OATP-B-expressing HEK293 cells.
I have been on TRT now for about 3 months. Ive noticed very sore and puffy nipples. I actually can feel the swollen gland in my nipple. Ive been taking 200mg/week test, .25mg anastrozole EOD. I just had my labs done and my test was 1200 and E2 21. The only abnormal was my Estrone was 87 with top scale being 77. Does anyone have any idea why this is happening? I thought controlling my E2 was not going to let this happen. Should I take clomid to help rid the estrogen from my receptors? Im just ...
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In our continuing quest to design efficient inhibitors of estrone sulfatase activity and to assess the recognition of estrone sulfate surrogates by estrone sulfatase, we synthesized and evaluated several sulfonate derivatives of 5,6,7,8-tetrahydronaphth-2-ol and estrone. 5,6,7,8-Tetrahydronaphth-2-methanesulfonate (11), and 5,6,7,8-tetrahydronaphth-2-(p-toluene)sulfonate (12) were found not to inhibit estrone sulfatase activity; estrone-3-methane-sulfonate (5), estrone-3-ethanesulfonate (6), estrone-3-butanesulfonate (7), and estrone-3-[(+)10-camphor]sulfonate (8) all weakly inhibited estrone sulfatase, and the best inhibitor, from this class of compounds, was estrone-3-(p-toluene)sulfonate (9). At 10 microM, it inhibited estrone sulfatase activity by 91%. These results emphasize some of the requirements needed for high-affinity binding to the enzyme.
OBJECTIVES : The purpose of this study was to evaluate the effect of cigarette smoking and alcohol use on the risk of endometrial cancer. The impact of smoking on serum estrone, estradiol, and androstenedione levels also was examined. STUDY DESIGN : This hospital-based case-control study included 168 women with endometrial carcinoma and 334...
A series of novel D-ring modified derivatives of estrone was synthesized and tested as inhibitors of steroid sulfatase (STS). The steroidal D-ring was cleaved via an iodoform reaction and thermal condensation of the resulting marrianolic acid derivative gave 16,17-seco-estra-1,3,5(10)-triene-16,17-imide derivatives, where a piperidinedione moiety is in place of the D-ring. This synthetic approach was found to give a higher overall yield than the literature method of Beckmann rearrangement. A range of alkyl side chains have been introduced on the nitrogen atom of the imido-ring and the corresponding 3-O-sulfamates synthesized. The new D-ring modified estrone derivatives bearing a propyl (39) and a 1-pyridin-3-ylmethyl (46) moiety had IC(50) values of 1 nM when tested in placental microsomes for the inhibition of STS. These compounds are therefore up to 18-fold more potent than EMATE, the very first highly potent irreversible steroidal STS inhibitor.
Dr. Weeks Comment: High testosterone is considered by some as a risk for prostate cancer. Many of us have suspected high estrogen instead and the research is driving the attention here, to estrone, and away from testosterone. Have your estrone level tested if you are worried about prostate cancer. …In this cohort of older men, higher estrone levels were strongly associated with an increased risk of incident prostate cancer…. Sex hormones and the risk of incident prostate cancer.. Urology. 2010 Nov;76(5):1034-40. Epub 2010 May 7.. Daniels NA, Nielson CM, Hoffman AR, Bauer DC; Osteoporotic Fractures In Men (MrOS) Study Group.. Abstract. OBJECTIVE: To assess whether sex hormone levels are associated with subsequent development of prostate cancer.. METHODS: A case-cohort study was conducted within the ongoing Osteoporotic Fractures in Men cohort study of community-dwelling men ≥ 65 years old recruited at 6 US clinical sites. After a mean follow-up of 4.7 years, all men with ...
Hormonin tablets contain three active ingredients: estradiol, estriol and estrone (previously spelt oestradiol, oestriol and oestrone in the UK). These are all naturally occuring forms of the main female sex hormone, oestrogen.
A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate. . ...
Dr. Gregory Lewis answered: Estradiol: Estradiol is synthesized via aromatase from testosterone. Estrone is synthesized via arom...
These data indicate that the hormonal effects due to moderate alcohol consumption are seen early, within 4 weeks of initiation of ingestion.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Materials. [3H]Methotrexate (46.8 Ci/mmol) and [3H]folate (30 Ci/mmol) were obtained from Moravek Biochemicals (Brea, CA), [3H]cimetidine (25.0 Ci/mmol) was from GE Healthcare (Chalfont St. Giles, UK) and [3H]estrone sulfate (57.3 Ci/mmol) and [3H]taurocholate (1.2 Ci/mmol) were from PerkinElmer Life Sciences, Inc. (Boston, MA). Folate, methotrexate, 5-methyltetrahydrofolate, folinate, geneticin, and sulfasalazine were obtained from Sigma-Aldrich Co. (St. Louis, MO). Zinc protoporphyrin IX (Calbiochem, San Diego, CA) was obtained from Merck (Darmstadt, Germany). Restriction enzymes were obtained from TOYOBO (Tokyo, Japan). All other reagents were of analytical grade and commercially obtained.. Cell Culture. Human embryonic kidney (HEK)293 and MDCKII cells were maintained at 37°C and 5% CO2 in Dulbeccos modified Eagles medium with 10% fetal bovine serum, 100 U/ml penicillin, and 100 μg/ml streptomycin.. Isolation of hPCFT/HCP1. The cDNA of hPCFT/HCP1 was cloned from the human intestine total ...
advanced pms complex clinically proven nutrients for nutritional pms support - BioResponse DIM - Patented, enhanced bioavailability and clinically proven to help balance hormones - Chasteberry extract - Clinically shown to help reduce PMS symptoms - Natural PMS support herbs and select nutrients including Calcium Clinical research has shown that the ingredients in PMSHarmony, including BioResponse DIM, Calcium, Magnesium, Vitamin D and Chasteberry extract help decrease many of the symptoms associated with PMS and help balance hormones. BioResponse DIM is a naturally-occurring indole found in cruciferous vegetables. Clinical research has shown it helps support healthy estrogen metabolism by increasing production of good estrogen metabolites, such as 2-hydroxy estrone, while reducing harmful metabolites, such as 16 alpha-hydroxy estrone. Patented BioResponse DIM utilizes solubility-enhancing micro-encapsulation technology that encases small particles of Diindolylmethane within a
1793 Purpose: To evaluate the associations of genetic polymorphisms in estrogen synthesis and metabolism enzymes CYP19, 17β-HSD1, CYP1A1, and CYP1A2 genes with blood levels of sex hormones among postmenopausal Chinese women. Method: Included in this study were 420 postmenopausal community controls from a population-based case-control study conducted in Shanghai. Fasting blood samples from those women were measured for blood DHEA, estradiol, estrone, estrone-sulfate, SHBG and testosterone. Genetic polymorphisms in the CYP19 codon 264, CYP1A1, and CYP1A2 were genotyped using PCR-RFLP methods. The CYP19 3-bp deletion and 17β-HSD1 (TTTA)n repeat and 12-bp deletion in 5′-UTR were genotyped by detecting fluorescent PCR amplimers on an ABI3700 automated DNA sequencer. Differences in plasma levels of hormones by genotypes were examined using variance analysis. Results: The geometric means of plasma levels of DHEA, estradiol, estrone, estrone-sulfate, SHBG and testosterone are 627.09 ng/ml, 10.41 ...
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Dehydration of theophylline monohydrate powder-effects of particle size and sample weight. Int J Pharma 1994 106 33-40. Ahlneck C, Zografi G. The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state. Int J Pharm 1990 62 87-95. Ahmed S, Owen CP, James K, Patel CK, Patel M. Acid dissociation constant, a potential phys-icochemical factor in the inhibition of the enzyme estrone sulfatase ES . Bioorg Med Chem Lett 2001, 9 Apr 11.... ...
Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491 ...
Words starting with E (page 62): estrepement, estrepes, estreping, estrich, estridge, estrildid, estrin, estriol, estro, estrogen, estrogenic, estrogenically, estrogens, estrone, estros, estrous, estrual, estrum, estrus, ests...
The best 29 synonyms for hormone, including: adrenaline, cholecystokinin, estrone, endocrine-gland, endocrine, internal secretion, oestrogen, leptin, gonadotropin, testosterone, progesterone and more... Find another word for hormone at YourDictionary.
2-Deoxy-2-fluoro-D-glucopyranosides derived from phenol, estrone and 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose were prepared and the rates of acid hydrolysis of phenyl β-D-glucopyranoside and phenyl 2-deoxy-2-fluoro-β-D-glucopyranoside compared.. ...
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Estriol 16-a-glucuronide is intended for Pharmaceuticals applications. All information about [2H3]-Estriol 16-a-glucuronide is provided in the MSDS. We deliver compounds with high purity levels and a comprehensive Certificate of Analysis. Connect to your member account to consult the documents ...
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Fingerprint Dive into the research topics of Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: Estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1. Together they form a unique fingerprint. ...
TY - JOUR. T1 - Circulatory responses to systemic infusions of estrone and estradiol-17α in nonpregnant, oophorectomized ewes. AU - Rosenfeld, Charles R.. AU - Rivera, Richard. PY - 1978/10/15. Y1 - 1978/10/15. N2 - Uterine arterial blood flow dose-response curves to systemic infusions of either estrone (E1) or estradiol-17α (E2α) were determined in ten oophorectomized, nonpregnant ewes. Maximum uterine blood flow occurred with 5 μg per kilogram of E1 and ≥ 20 μg per kilogram of E2α. Total uterine blood flow measured with isotope-labeled microspheres rose more than tenfold following 30 μg per kilogram of either estrogen, as did blood flow to the myometrium, endometrium, and uterine caruncles (p , 0.05). Distribution of uterine blood flow was unaltered. Cervical and vaginal blood flows increased ten-to twenty-fold with E1 and E2α, while mammary gland blood flow rose 54 and 77 per cent. Significant increases in adrenal and thyroid blood flows were documented. The only significant ...
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Dr. Joshua Gatson, Assistant Professor of Surgery at the University of Texas Southwestern Medical Center in Dallas, investigates biomarkers and novel therapies for traumatic brain injury. His previous work has shown that estrone, one of the three naturally occurring estrogen hormones in the body, has shown some promise in reducing inflammation and cell death in the brain. His latest study is the first to demonstrate estrone provides those anti-inflammatory and antioxidant capabilities after traumatic brain injury. It is likewise the first to reveal the cellular pathways that are involved. His findings will be presented April 22, 2012 during Experimental Biology 2012 in San Diego, CA.. The study, conducted in male rats, compared 0.5 mg of estrone to a placebo, both given 30 minutes after the injury. It demonstrated that estrone is involved in promoting brain-derived neurotrophic factor (BDNF), which promotes cell survival. BDNF, one of the main growth factors that regulates repair following ...
These three chemicals make up human estrogen. The estrogen that has the most volume in the body is estriol (60-80% of circulating estrogens), followed by estradiol and estrone (10-20% each). Estriol is thought to be the weakest acting hormone, but provides a natural hormonal balance in the body, whereas estradiol and estrone are thought be the stronger estrogens. The female body produces large amounts of estriol during pregnancy and has protective properties against such things as estrogen related cancers. Estradiol is the estrogen that can relieve vaso-motor symptoms the best. Estrone is the primary estrogen found in post-menopausal women. It stores it self in the body fat and has more know cancer properties. ...
Looking for Dehydroepiandrosterone sulfate? Find out information about Dehydroepiandrosterone sulfate. C19H28O2 Dimorphous crystals with a melting point of 140-141°C, or leaflet crystals with a melting point of 152-153°C; soluble in alcohol, benzene, and... Explanation of Dehydroepiandrosterone sulfate
Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not
use.. Androstenedione offers a fast-acting, over-the-counter alternative to prescription-only testosterone patches, creams and lotions. It is sold in capsules or pills for oral use, and it has recently become available in a liquid spray for sublingual use. The sublingual spray raises testosterone levels in less than 30 minutes.. The problem with androstenedione is that it is quickly metabolized into estrogens. Estrogens have strong anti-testosterone-like metabolic effects that last for a long time (days as opposed to hours). Androstenedione produces estrogens through two separate pathways. First, it can be directly metabolized into estrone (see Figure 1). Second, it can be metabolized to testosterone and then to estradiol. Both estradiol and estrone are strong estrogens which suppress the anabolic, metabolism-enhancing, fat-loss and tissue-healing properties of testosterone. I believe that many people will suffer estrogen-related side effects from androstenedione that will have far more negative ...
Oestriol hormone. Molecular model of the structure of the female sex hormone oestriol. Atoms are represented as rods and are colour-coded: carbon (blue), hydrogen (gold), and oxygen (red). Oestriol is one of three naturally occurring oestrogens, a class of hormones that are associated with the development of the female reproductive organs and secondary sex characteristics. Oestriol is produced at high levels by the placenta during pregnancy, although it is secreted by the ovaries at low levels in non-pregnant women. If oestriol levels are abnormally low during pregnancy, this can indicate that there is a problem with the development of the foetus. - Stock Image A619/0147
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Specific Aim 1: To determine whether aromatase activity is measurable in adipose tissue using the compound (see appendix) as a precursor and whether aromatase is decreased in the adipose tissue of obese women, and whether this varies by regional fat location. The investigators will accomplish this by examining precursor/product ratios of hormones infused through microdialysis using the compound as a substrate.. Hypothesis for specific aim 1: Aromatase activity will be measurable in adipose tissue using testosterone as a precursor. Estradiol, but not estrone production from androgen precursors will be decreased in obese women relative to those of normal weight.. Specific Aim 2: To determine whether nonspecific, systemic suppression of inflammation will lead to improved reproductive hormonal profiles of luteinizing hormone (LH), follicle stimulating hormone(FSH), Estrone conjugates (E1c) and pregnandiol glucuronide (Pdg) in obese women who undergo two menstrual cycles of study: one off ...
A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.
Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 15nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo . Orally active.
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After ovulation the ovary releases progesterone into the bloodstream and helps prepare the uterus for embryo implantation. Progesterone will get metabolized by the liver and secreted into the urine as PdG. Published studies show Progesterone in serum directly correlates with urine PdG after ovulation. Progesterone is the precursor of urinary pregnanediol glucuronide . Treat pain after menopause. Where to buy cheapest progesteronum online. What Progesterone Replacement Therapy Is progesteronum The uncommon instances of liver damage reported throughout progestin remedy have invariably been self-limiting and have resolved completely with stopping the progesterone preparation.If youre battling the symptoms above you arent alone.Cross sensitivity to estrogen therapy has not been demonstrated in sufferers creating jaundice throughout progesterone remedy, however may be expected.Research suggests they might even have helpful results on hormonal health, together with decreasing ranges of the stress ...
I am new to cell culture and no one in my dept has worked with hormones before so I am completly out of my element here. My question is what stock concentration people use when working with estrogen and progesterone? I need a final estrogen concentration of 10-8 and a final progesterone cencentration of 10-7. I have already tried making stocks and working solutions myslef, but the cells never expressed markers of differentiation which that are supposed to do under hormone treatment. So I did something wrong ...
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  • Estrone, as well as the other estrogens, are synthesized from cholesterol and secreted mainly from the gonads, though they can also be formed from adrenal androgens in adipose tissue. (wikipedia.org)
  • Relative to estradiol, both estrone and estriol have far weaker activity as estrogens. (wikipedia.org)
  • Estrone is conjugated into estrogen conjugates such as estrone sulfate and estrone glucuronide by sulfotransferases and glucuronidases, and can also be hydroxylated by cytochrome P450 enzymes into catechol estrogens such as 2-hydroxyestrone and 4-hydroxyestrone or into estriol. (wikipedia.org)
  • In women, the chemical substance is chiefly produced in the ovaries, but the testes of males also secrete small amounts of estrone and other estrogens. (fsu.edu)
  • This test is used to measure estrone (E1) , one of three main estrogens in the body. (healthtestingcenters.com)
  • Estrone is one of the three estrogens , which also include estriol and estradiol . (wikidoc.org)
  • In males, estrone and the other estrogens are generated in minor amounts in the testes. (fsu.edu)
  • The endogenous estrogens (E) estradiol (E 2 ) and estrone (E 1 ) contribute to breast cancer risk through their role as growth promoters ( 1 - 4 ). (aacrjournals.org)
  • The 2 major biologically active estrogens in nonpregnant humans are estrone (E1) and estradiol (E2). (mayomedicallaboratories.com)
  • Natural estrogens include estrone , estradiol and estriol. (thefreedictionary.com)
  • Estrone is a steroid like estriol and estradiol, belonging to the class of estrogens. (biovendor.com)
  • Studies of metabolism of estrogens by MCF-7 cells revealed no conversion of estriol to either estrone or estradiol. (aacrjournals.org)
  • Estrone (3-hydroxy-1,3,5 (10)-estratrien 17-one) is beside estradiol and estriol one of the three major naturally occuring estrogens. (blockscientificstore.com)
  • One is the aromatase pathway, in which aromatase converts androgens to estrogens and the other is the sulfatase pathway, in which steroid sulfatase converts estrone-3-sulfate to estrone. (aspetjournals.org)
  • Estrone sulfate (E 1 S) 1 serves as a storage form of estrogens in the human circulation and is used in hormone replacement therapy. (aspetjournals.org)
  • It is metabolized primarily in liver to estrogens such as estrone, estradiol, and estriol. (aspetjournals.org)
  • In post-menopausal women, however, higher levels of estrone when compared to the other estrogens have been implicated in cardiovascular disease, stroke and certain types of cancer. (discountedlabs.com)
  • Imbalances in the relationship between estrone and the other two major estrogens are thought to increase the risk for many age-related diseases. (discountedlabs.com)
  • Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. (selfdecode.com)
  • Estrone (American English) (hu ua E1), lossis oestrone (British English), tseem hu ua estra-1,3,5 (10) -trien-3-ol-17-ib tug, yog ib qho tshuaj hormone estrogenic as Well as adipose cov ntaub so ntswg Nws yog ib qho ntawm ntau estrogens ntuj, uas kuj muaj estriol thiab estradiol. (ok-biotech.com)
  • Estrone, also known as folliculin or estrovarin, belongs to the class of organic compounds known as estrogens and derivatives. (bovinedb.ca)
  • Estrone is an odorless, solid crystalline powder, white in color with a melting point of 254.5 °C and a specific gravity of 1.23.Estrone is one of several natural estrogens, which also include estriol and estradiol. (steroid-raws.com)
  • Estrone is an estrogen, specifically an agonist of the estrogen receptors ERα and ERβ. (wikipedia.org)
  • In addition to its low estrogenic potency, estrone, unlike estradiol and estriol, is not accumulated in estrogen target tissues. (wikipedia.org)
  • In contrast to estradiol and estriol, estrone is not a ligand of the G protein-coupled estrogen receptor (affinity >10,000 nM). (wikipedia.org)
  • Estrone is excreted in urine in the form of estrogen conjugates such as estrone sulfate. (wikipedia.org)
  • Estrone benzoate, or estrone 3-benzoate, is a synthetic estrogen and estrogen ester - specifically, the C3 benzoate ester of estrone - which was first reported in 1932 and was never marketed. (wikipedia.org)
  • List of estrogen esters § Estrone esters J. Elks (14 November 2014). (wikipedia.org)
  • The truth is there are three types of estrogen: estrone, estradiol and estriol. (healthtestingcenters.com)
  • Generally, the estrogen most heavily secreted and most active in the body is estradiol, but this substance is soon converted to estrone when it enters the bloodstream. (fsu.edu)
  • Estrone is a degradation product of the endogenous estrogen steroid, estradiol. (sigmaaldrich.com)
  • The mechanism for maintaining high tumor tissue estrogen levels in post-menopausal women is unknown but could be related to the ability of plasma estrone sulfate to serve as a precursor for estradiol synthesis in tumor tissue. (nih.gov)
  • A molecular model of estrone, an estrogen hormone produced by the ovaries and adipose tissue, that is predominantly found in postmenopausal women. (sciencephoto.com)
  • Does high estrone equal estrogen dominance? (progesteronetherapy.com)
  • 16α-OH-estrone has been shown to be genotoxic and cause aberrant proliferation of mammary cells ( 21 , 22 ) and to covalently bind to the estrogen receptor ( 23 ). (aacrjournals.org)
  • Cytochrome P450 1B1 (CYP1B1) catalyses the conversion of estrone and estradiol to potentially carcinogenic catechol estrogen 4-hydroxyestrogen (4-OH). (thefreedictionary.com)
  • Estrone is a naturally occurring steroidal estrogen. (uspharmacist.com)
  • Although some active women had lower levels of estrone (because they were thinner), paradoxically those with more muscle mass had higher estrogen levels. (antiaging.com)
  • In postmenopausal women estrone is the major estrogen. (blockscientificstore.com)
  • Although circulating estrone-3-sulfate is a major precursor of biologically active estrogen, permeation across the plasma membrane is unlikely to occur by diffusion because of the high hydrophilicity of the molecule. (aspetjournals.org)
  • The object of this study was to clarify the involvement of specific transporter(s) in the supply of estrone-3-sulfate to human breast cancer-derived T-47D cells, which grow in an estrogen-dependent manner. (aspetjournals.org)
  • The expression of organic anion transporting polypeptides, OATP-D and OATP-E, which are candidate transporters of estrone-3-sulfate, was detected by reverse transcription-polymerase chain reaction analysis, although their actual involvement in the uptake of estrogen remains to be clarified. (aspetjournals.org)
  • In conclusion, the uptake of estrone-3-sulfate by T-47D cells was mediated by a carrier-mediated transport mechanism, suggesting that the estrogen precursor is actively imported by estrogen-dependent breast cancer cells. (aspetjournals.org)
  • Therefore, estrone-3-sulfate is thought to play an important role in the progression of breast cancer as a reservoir of active estrogen, even though estrone-3-sulfate itself is not very active biologically. (aspetjournals.org)
  • This is one form of bio-identical estrogen for hormone replacement therapy that contains 10% estrone, 10% estradiol, and 80% estriol. (drstallone.com)
  • HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo. (semanticscholar.org)
  • ESTRONE injections (Estragyn 5®) contain estrogen hormones. (yourcareeverywhere.com)
  • Estrone and estrogen injections are for injection into a muscle. (yourcareeverywhere.com)
  • Oral contraceptives and estrogen replacement therapy may influence Estrone levels. (umich.edu)
  • Estrone is the least abundant of the three and is relevant to health and disease because it is considered the stronger acting estrogen. (discountedlabs.com)
  • Estrone, also known as E1, may be measured in women who have gone through menopause to determine their estrogen levels. (usbio-chem.com)
  • In particular, Estrone and phosphoadenosine phosphosulfate can be converted into estrone sulfate and adenosine 3',5'-diphosphate through the action of the enzyme estrogen sulfotransferase. (bovinedb.ca)
  • Each of the three components of estrogen, estrone (E1), estradiol (E2) , and estriol (E3) serve an important, and very different function, in both males and females. (hrt.org)
  • To determine whether estrone sulfate was converted to free estrone and estradiol during this protocol, 3H-estrone sulfate was substituted for unlabelled steroid and castrate animals were again infused for 14 days. (nih.gov)
  • Steroid sulfatase (STS) catalyzes the hydrolyis of steroidal sulfates such as estrone sulfate (ES1) and is considered to be an attractive target in the treatment of steroid dependent cancers. (rsc.org)
  • Thus, estrone is considered to be a steroid lipid molecule. (bovinedb.ca)
  • The E1STS enzyme regulates the formation of E1 from estrone sulfate (E1S), a steroid conjugate present in high concentrations in tissue and blood in women with breast cancer. (kingston.ac.uk)
  • This contradicts some cell-free in-vitro research suggesting that high concentrations of estrone might be able to partially antagonize the actions of estradiol. (wikipedia.org)
  • Therefore, we assessed the human cytochrome P450-dependent oxidation of estrone using substrate concentrations that more closely approximate the maximum expected concentrations in breast tissue. (aacrjournals.org)
  • Estrone and estradiol concentrations were measured in morning fasting samples using liquid chromatography tandem mass spectrometry in men of Framingham Offspring Generation. (nih.gov)
  • Insulin decreased acyl-estrone synthesis at low concentrations and with little change over time. (portlandpress.com)
  • The apparent dissociation constant is lower for estradiol than for estrone and estriol, but all three bind to an equal number of sites when saturating concentrations are used. (aacrjournals.org)
  • Intended Use Bovine Estrone ELISA Kit allows for the in vitro quantitative determination of Estrone , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids. (biobool.com)
  • Because its structure is so simple, many methods for the complete chemical synthesis of estrone have been developed. (thefreedictionary.com)
  • and (b) synthesis of oleoyl-estrone from cell estrone. (portlandpress.com)
  • However, the administration of AR inhibitors alone does not prevent the localised biosynthesis of estrone (E1) (and therefore the subsequent synthesis of E2) within breast tumour cells via alternative non-AR routes. (kingston.ac.uk)
  • The principal pathway involves androstenedione as an intermediate, with androstenedione being transformed into estrone by the enzyme aromatase. (wikipedia.org)
  • In addition to aromatization of androstenedione, estrone is also formed reversibly from estradiol by the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD) in various tissues, including the liver, uterus, and mammary gland. (wikipedia.org)
  • Estrone is synthesized via aromatase from androstenedione , a derivative of progesterone . (wikidoc.org)
  • Androstenedione converting to estrone. (wikidoc.org)
  • He had also raised follicle-stimulating hormone (FSH), luteinizing hormone (LH), androstenedione, and estrone with low-normal testosterone, low androstendiol glucurunide, and normal DHEA levels [Table 2]. (thefreedictionary.com)
  • However, oestrogens are continually synthesised via peripheral conversion of androstenedione (Adione) to estrone (E1) through the action of aromatase, a cytochrome P450 (CYP450) enzyme. (thefreedictionary.com)
  • Obesity was the primary determinant of estrone and estradiol even after controlling for androstenedione. (antiaging.com)
  • Estrone is produced primarily from androstenedione. (blockscientificstore.com)
  • In premenopausal women excessive estrone levels can result from the conversion of large amounts of androstenedione produced in polycystic ovary syndrome (6) and ovarian tumors. (blockscientificstore.com)
  • Estrone sulfate plasma levels are 30-fold higher than free estradiol levels in post-menopausal women and estrone sulfatase is present in many tissues, including breast tumors, supporting this hypothesis. (nih.gov)
  • I still cannot find an explanation as to why a 36 year old woman would have such high estrone levels- (508 pg/mL) it seems these numbers only exist for post-menopausal women. (progesteronetherapy.com)
  • Let me quote some of Cauley's statements: "Physical activity was an independent predictor of serum estrone. (antiaging.com)
  • We have demonstrated that moderate alcohol consumption (15 g/d, 30 g/d) for 8 weeks resulted in significantly increased levels of serum estrone sulfate and DHEAS in 51 postmenopausal women in a randomized, placebo-controlled trial. (nih.gov)
  • We now report on the relationships between serum estrone sulfate and dehydroepiandrosterone sulfate (DHEAS) levels after 4 weeks of moderate alcohol supplementation, and compare the results to the 8 weeks data to elucidate time-to-effect differences. (nih.gov)
  • We found no significant differences between the absolute levels of serum estrone sulfate at week 4 versus week 8 (P = 0.32) across all doses. (nih.gov)
  • In situ uptake of [2,4,6,7-3H(N)]estrone ([3H]E1) by the major phylogenetic groups present in activated sludge samples from two different municipal wastewater treatment plants was investigated using microautoradiography-fluorescence in situ hybridization (MAR-FISH). (biomedsearch.com)
  • Overall uptake of estrone (i.e., the sum of free and acyl-estrone) by cells was not affected by leptin or corticosterone, but strongly reduced by insulin. (portlandpress.com)
  • The initial uptake rate of estrone-3-sulfate kinetically exhibited a single saturable component, with K m and V max values of 7.6 μM and 172 pmol/mg of protein/min, respectively. (aspetjournals.org)
  • The replacement of extracellular Na + with Li + , K + , or N -methylglucamine + had no effect on the uptake of [ 3 H]estrone-3-sulfate. (aspetjournals.org)
  • Estrone-3-sulfate uptake was time-dependent and higher in SER than in RER vesicles. (uzh.ch)
  • Inhibition of steroidsulfatase mediated estrone-3-sulfate hydrolysis decreased estrone-3-sulfate uptake but had no effect on taurocholate or estradiol-17β-glucuronide transport. (uzh.ch)
  • Oral administration of menopausal replacement dosages of estradiol results in low, follicular phase levels of estradiol, whereas estrone levels resemble the high levels seen during the first trimester of pregnancy. (wikipedia.org)
  • During the follicular phase of the menstrual cycle the estrone level shows a slight increase. (biovendor.com)
  • Female Ludwig Alopecia (FAGA) is, in my opinion, nearly always the result of Telogen Effluvium or of low levels in follicular estrone activity! (sitri.it)
  • During the follicular phase of the menstrual cycle the estrone level increases with a clear peak around day 13. (blockscientificstore.com)
  • This reaction occurs in both the gonads and in certain other tissues, particularly adipose tissue, and estrone is subsequently secreted from these tissues. (wikipedia.org)
  • Short-term OE (oleoyl-estrone) treatment causes significant decreases in rat weight mainly due to adipose tissue loss. (biomedcentral.com)
  • The expression profile of the 1168 genes included in the specific Atlas Rat Array 1.2 (Clontech) was analyzed in the mesenteric white adipose tissue from control animals and treated with oleoyl-estrone. (biomedcentral.com)
  • Estrone (E1, and also oestrone) is an estrogenic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. (steroid-raws.com)
  • 2002) stated that in vitro callus culture of immature wheat embryos is strongly stimulated by androsterone but regeneration is similar to control estrone and progesterone inhibits the first leaf and a callus growth of immature embryos in in vitro culture. (thefreedictionary.com)
  • Please note that estrodiol is 12 times more potent than estrone , and in the presence of adequate progesterone, estrodiol will often be converted to estrone sulfate, an essentially inactive form that is stored mainly in the fat cells for later use as needed. (thefreedictionary.com)
  • Hormone-dependent mammary tumors were induced in virgin GR mice by treatment with estrone and progesterone. (aacrjournals.org)
  • The results might indicate that estrone and progesterone treatment stimulated growth of hormone-dependent GR mouse mammary tumors mainly by an increase of growth fraction and cell production rate. (aacrjournals.org)
  • Estrone is one the three major hormones that are predominantly involved in the maintenance of the female reproductive system and secondary sexual characteristics. (fsu.edu)
  • Estrone is the least prevalent of the three hormones , estradiol being prevalent almost always in a female body, estriol being prevalent primarily during pregnancy . (wikidoc.org)
  • Estrone is one of the three major hormones that chiefly influence the female reproductive system. (fsu.edu)
  • Two essential intrafollicolar hormones regulate hair cycles: diidrotestosterone ed estrone. (sitri.it)
  • The ability of a variety of nanofiltration and reverse osmosis membranes to retain the natural hormone estrone are examined here as a function of solution conditions. (ed.ac.uk)
  • Waite, T. D. / Adsorption of Estrone on nanofiltration and reverse osmosis membranes in water and wastewater treatment . (ed.ac.uk)
  • Nghiem, DL, Schaefer, A & Waite, TD 2002, ' Adsorption of Estrone on nanofiltration and reverse osmosis membranes in water and wastewater treatment ', Water Science and Technology , vol. 46, no. 4-5, pp. 265-272. (ed.ac.uk)
  • Estrone (also oestrone ) is an estrogenic hormone secreted by the ovary . (wikidoc.org)
  • Hormonin tablets contain three active ingredients: estradiol, estriol and estrone (previously spelt oestradiol, oestriol and oestrone in the UK). (netdoctor.co.uk)
  • Oestrogen (in this case in the form of estradiol, estriol and estrone) can be given as a supplement to replace the falling levels in the body and help reduce these distressing symptoms of the menopause. (netdoctor.co.uk)
  • Molecular model of the female sex hormone estrone (C18.H22.O2), one of the three main oestrogens produced by the human body (estradiol, estriol and estrone). (sciencephoto.com)
  • These findings confirm that estrone has very low estrogenic activity, and also indicate that estrone does not diminish the estrogenic activity of estradiol. (wikipedia.org)
  • Estrone is relevant to health and disease due to its conversion to estrone sulfate, a long-lived derivative of estrone. (wikidoc.org)
  • The major pathways for metabolism of estradiol are through conversion to estrone and oxidation to 2-OH-estrone and 16α-OH-estrone. (aacrjournals.org)
  • Estrone is known to be a carcinogen for human females as well as cause breast tenderness or pain, nausea, headache, hypertension, and leg cramps.In men, estrone has been known to cause anorexia, nausea, vomiting, and erectile disfunction.Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. (steroid-raws.com)
  • After menopause, estrone levels do not decline as dramatically as estradiol levels. (blockscientificstore.com)
  • In menopause, estrone is most plentiful. (hrt.org)
  • More specifically, the estradiol and estrone forms are produced primarily in the ovaries in premenopausal women, while estriol is produced by the placenta during pregnancy. (thefreedictionary.com)
  • Until the 4th to 6th week of pregnancy, estrone originates primarily from maternal sources such as the ovaries, adrenals, or peripheral conversion thus remaining within the normal values (4). (blockscientificstore.com)
  • After the 6th to 10th week of pregnancy the values increase gradually due to placental secretion of estrone. (blockscientificstore.com)
  • Circulating levels (mean +/- SD) of estrone sulfate (E1S), estrone (E1) and estradiol-17 beta (E2) were measured in normal and cirrhotic postmenopausal women matched for body weight and age. (nih.gov)
  • As for more intense exercise, Cauley cites a 1988 study by Nelson that showed that postmenopausal women who ran 23 miles a week had lower estrone levels than age-matched sedentary women. (antiaging.com)
  • In prepubertal children, men and postmenopausal women, the major portion of estrone is derived from peripheral tissue conversion (2). (blockscientificstore.com)
  • Estrone is naturally produced by the ovaries in women and the fat tissue linings in children, men, and postmenopausal women. (usbio-chem.com)
  • Estrone was first isolated in 1929 from the urine of pregnant women by A. Butenandt and the American biochemist E. Doisy. (thefreedictionary.com)
  • Assay Estrone levels in Dried Fecal Extracts, Urine and Tissue Culture Media. (fishersci.com)
  • In our continuing quest to design efficient inhibitors of estrone sulfatase activity and to assess the recognition of estrone sulfate surrogates by estrone sulfatase, we synthesized and evaluated several sulfonate derivatives of 5,6,7,8-tetrahydronaphth-2-ol and estrone. (ox.ac.uk)
  • Estrone exists as a solid, very hydrophobic, practically insoluble (in water), and relatively neutral molecule. (bovinedb.ca)
  • Estrone is found not only in animals and humans, but also in certain fruits, such as the coconut, apple, and pomegranate. (thefreedictionary.com)
  • Estrone exists in all living organisms, ranging from bacteria to humans. (bovinedb.ca)
  • Estrone is a naturally occurring steroidal oestrogen. (mims.com)
  • We describe the docking of selected steroidal and non-steroidal estrone sulphatase inhibitors, including the Phase I clinical trial candidate 667COUMATE (6), into the active site of human carbonic anhydrase II (hCA II). (ox.ac.uk)
  • The amount of enzyme conjugate complex (HRP-avidin: biotin-labelled estrone) bound to the antibody is inversely proportional to the concentration of the unlabeled estrone. (bio-medicine.org)
  • The optical density is inversely proportional to the concentration of estrone present in the serum. (bio-medicine.org)
  • These changes of estrone concentration are in parallel to that of estradiol (3). (blockscientificstore.com)
  • The concentration of Estrone in the samples is then determined by comparing the O.D. of the samples to the standard curve. (biobool.com)
  • The in vitro metabolism of estrone by recombinant human cytochrome P450 enzymes and human liver microsomes was studied. (aacrjournals.org)
  • In cattle, estrone is involved in the metabolic pathway called the estrone metabolism pathway. (bovinedb.ca)
  • Estrone, Estradiol, and Estriol make up the natural hormone Triestrogen. (drstallone.com)
  • Adsorption of the trace contaminant estrone, a natural hormone and commonly abundant in surface waters and in treated as well as untreated wastewaters, to eight commercial nanofiltration (NF) and reverse osmosis (RO) membranes was investigated under welldefined conditions. (ed.ac.uk)
  • Estrone sulfate acts as a pool of estrone which can be converted as needed to the more active estradiol. (wikidoc.org)
  • Estrone was first isolated in 1929 by Edward Adelbert Doisy, an American biochemist who later isolated estriol and estradiol as well. (fsu.edu)
  • Within the female body, estrone is primarily produced in the ovaries, but is also exuded in smaller amounts by the adrenal glands. (fsu.edu)
  • Human oestrogenic 17beta-hydroxysteroid dehydrogenase specificity: enzyme regulation through an NADPH-dependent substrate inhibition towards the highly specific oestrone reduction. (semanticscholar.org)
  • Here we report the steady-state kinetics for 17beta-HSD1 at 37 degrees C and pH 7.5, using a homogeneous enzyme preparation with oestrone, dehydroepiandrosterone (DHEA) or dihydrotestosterone (DHT) as substrate and NADP(H) as the cofactor. (semanticscholar.org)
  • Product Description specifical Bovine Estrone ELISA Kit is based on the competitive binding enzyme immunoassay technique. (biobool.com)
  • With oral administration of estradiol, the ratio of estradiol levels to estrone levels is about 5 times higher on average than under normal physiological circumstances in premenopausal women and with parenteral (non-oral) routes of estradiol. (wikipedia.org)
  • In spite of markedly elevated levels of estrone with oral estradiol but not with transdermal estradiol, clinical studies have shown that dosages of oral and transdermal estradiol achieving similar levels of estradiol possess equivalent and non-significantly different potency in terms of measures including suppression of luteinizing hormone and follicle-stimulating hormone levels, inhibition of bone resorption, and relief of menopausal symptoms such as hot flashes. (wikipedia.org)
  • In addition, estradiol levels were found to correlate with these effects, while estrone levels did not. (wikipedia.org)
  • Describing Cauley's study, Love writes: "Women who were physically active also had higher blood levels of estrone. (antiaging.com)
  • If women who were physically active also had higher levels of estrone, than exercise sounds like a wonderful way to increase one's own estrone production. (antiaging.com)
  • More active women had lower levels of estrone. (antiaging.com)
  • Parenthetically, I can't resist pointing out that looking at estrone in relation to exercise may be really missing the bigger point, which is THE DRAMATIC IMPACT OF EXERCISE ON INSULIN LEVELS. (antiaging.com)
  • Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingha. (nih.gov)
  • Age trends in estradiol and estrone levels in men and how lifestyle factors, comorbid conditions, testosterone, and sex hormone-binding globulin affect these age trends remain poorly understood, and were examined in men of the Framingham Heart Study. (nih.gov)
  • Collectively, age, BMI, testosterone, and other health and behavioral factors explained only 18% of variance in estradiol, and 9% of variance in estrone levels. (nih.gov)
  • Men in the highest quintile of estrone levels had significantly higher age and BMI, and a higher prevalence of smoking, diabetes, and cardiovascular disease than others, whereas those in the highest quintile of estradiol had higher BMI than others. (nih.gov)
  • Total estrone and estradiol levels in men, measured using liquid chromatography tandem mass spectrometry, revealed significant age-related increases that were only partially accounted for by cross-sectional differences in BMI, diabetes status, and other comorbidities and health behaviors. (nih.gov)
  • Changes in estrone sulfate and DHEAS levels from placebo to 15 g and 30 g alcohol per day were estimated using linear mixed models. (nih.gov)
  • Oral administration of the estrone ester, however, prevents these effects by maintaining low plasma levels of both estrone and estradiol. (biomedcentral.com)
  • 1-14 days: Estrone levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days. (testcatalog.org)
  • Blood testing to measure levels of estrone, estradiol, and estriol is used to help diagnose a number of medical conditions in both females and males. (hrt.org)
  • Experiments were conducted in stainless steel stirred cells by spiking trace levels (100ng.L-1) of estrone into five different matrices, namely MilliQ water, a bicarbonate solution, synthetic natural waters containing natural organics, and secondary effluent. (ed.ac.uk)
  • The current study aims to investigate the transport of taurocholate, estradiol-17β-glucuronide, and estrone-3-sulfate in smooth (SER) and rough (RER) endoplasmic reticulum membrane vesicles isolated from Wistar and TR(-) rat liver. (uzh.ch)
  • Based on inhibition studies and transport characteristics, three different transport mechanisms are suggested to be involved in the transport of taurocholate, estrone-3-sulfate and estradiol-17β-glucuronide across the ER membrane. (uzh.ch)
  • Estrone can be converted into estradiol, and serves mainly as a precursor or metabolic intermediate of estradiol. (wikipedia.org)
  • As such, estrone is considered to be a precursor or prohormone of estradiol. (wikipedia.org)
  • Clinical research has confirmed the nature of estrone as a relatively inert precursor of estradiol. (wikipedia.org)
  • The medicines below all contain the following active ingredient(s): oestrone sulfate sodium. (healthdirect.gov.au)
  • Solid-phase enzymoimmunoassay of estrone in saliva. (biovendor.com)
  • Estrone Saliva Luminescence Immunoassay is intended for the quantitative determination of estrone in human saliva. (ibl-international.com)
  • The measurement of estrone in saliva is attractive because it's non-invasive, has stress-free procedure and makes serial sampling easy. (ibl-international.com)
  • The DRG Estrone ELISA Kit provides materials for the quantitative determination of Estrone in serum and plasma. (blockscientificstore.com)
  • ELISA for the quantitative determination of Estrone in human serum. (invitech.co.uk)
  • Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II. (ox.ac.uk)
  • Estrone sulfonates as inhibitors of estrone sulfatase. (ox.ac.uk)
  • Castrate rats bearing nitrosomethylurea-induced mammary tumors were infused with estradiol as a control or estrone sulfate over a 14-day period. (nih.gov)
  • To this end, Wistar female rats received daily oral gavages of 10μmol/kg per d oleoyl-oestrone in sunflower oil, or vehicle alone for 10 or 20d. (cambridge.org)
  • A second group of rats received the gavage of sunflower oil and the same amount of food ingested as the oleoyl-oestrone-treated animals (pair-fed group). (cambridge.org)
  • Wistar rats were subjected to an oral treatment with oleoyl-estrone. (biomedcentral.com)
  • 2017. https://www.tabers.com/tabersonline/view/Tabers-Dictionary/744368/all/estrone. (tabers.com)
  • Your search returned 2 Estrone ELISA ELISA Kit across 1 supplier. (biocompare.com)
  • Inquiry About Bovine Estrone ELISA Kit If you hope to order it or contact us directly, please contact us via [email protected] (biobool.com)
  • 2′-Deoxynucleoside conjugates of 13α-estrone were synthesized by applying the copper-catalyzed alkyne-azide click reaction (CuAAC). (mdpi.com)
  • It catalyses the reaction of 3′‐phosphoadenylylsulfate with estrone to form the inactive estrone 3‐sulfate with release of adenosine 3′,5′‐bisphosphate. (oup.com)
  • The microtiter plate provided in th is kit has been pre-coated with an antibody specific to Estrone, During the reaction,Estrone in the sample or standard competes with a fixed amount of biotin-labeled Estrone for sites on a pre-coated Monoclonal antibody specific to Estrone. (biobool.com)

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