Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Tumors or cancer of the ESOPHAGUS.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Tumors or cancer of the STOMACH.
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
Acquiring information from a patient on past medical conditions and treatments.
Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)
Systematic and thorough inspection of the patient for physical signs of disease or abnormality.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
The separation and isolation of tissues for surgical purposes, or for the analysis or study of their structures.
Endoscopic examination, therapy or surgery of the gastrointestinal tract.
Endoscopic examination, therapy or surgery of the interior of the stomach.
Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. It mediates proper CHROMOSOME SEGREGATION and contractile ring function during CYTOKINESIS.
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell division, including centrosome duplication, SPINDLE APPARATUS formation, chromosome alignment, attachment to the spindle, checkpoint activation, and CYTOKINESIS.
An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION.
Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. It is found primarily in GERM CELLS in the TESTIS, and may mediate CHROMOSOME SEGREGATION during SPERMATOGENESIS.
The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.
A dental specialty concerned with pathology of the oral cavity.
Physiological or psychological effects of periods of work which may be fixed or flexible such as flexitime, work shifts, and rotating shifts.
Characteristics or attributes of persons or things which elicit pleasurable feelings.
An order comprising three families of tailed bacteriophages: MYOVIRIDAE; PODOVIRIDAE; and SIPHOVIRIDAE.
A family of wingless, blood-sucking insects of the suborder HETEROPTERA, including the bedbugs and related forms. Cimex (BEDBUGS), Heamatosiphon, and Oeciacus are medically important genera. (From Dorland, 28th ed)
That part of the STOMACH close to the opening from ESOPHAGUS into the stomach (cardiac orifice), the ESOPHAGOGASTRIC JUNCTION. The cardia is so named because of its closeness to the HEART. Cardia is characterized by the lack of acid-forming cells (GASTRIC PARIETAL CELLS).
A malignant epithelial tumor with a glandular organization.
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
A subspecialty of pathology concerned with the molecular basis (e.g., mutations) of various diseases.
MOLECULAR BIOLOGY techniques used in the diagnosis of disease.

Multiple target sites of allelic imbalance on chromosome 17 in Barrett's oesophageal cancer. (1/4657)

Twelve Barrett's adenocarcinomas have been analysed for the occurrence of allelic imbalance (LOH) on chromosome 17 using 41 microsatellite markers. This study provides evidence for 13 minimal regions of LOH, six on 17p and seven on 17q. Four of these centre in the vicinity of the known tumour suppressor genes (TSGs) TP53 (17p13.1), NFI (17q11.2), BRCA1 (17q21.1), and a putative TSG (17p13.3). The tumours all displayed relatively small regions of LOH (1-10 cM), and in several tumours extensive regions of LOH were detected. One tumour displayed only two very small regions of LOH; 17p11.2 and 17p13.1. The frequency of allelic imbalance has been calculated based on the LOH encompassing only one minimal region, and based on all the LOH observations. By both evaluations the highest LOH frequencies were found for regions II (p53), III (17p13.1 centromeric to p53), IV (17p12), V (17p11.2) and VII (NF1, 17q11.2). Our data supports the existence of multiple TSGs on chromosome 17 and challenges the view that p53 is the sole target of LOH on 17p in Barrett's adenocarcinoma.  (+info)

Effects of soybean oil emulsion and eicosapentaenoic acid on stress response and immune function after a severely stressful operation. (2/4657)

OBJECTIVE: To investigate the effects of soybean oil emulsion and oral or enteral administration of eicosapentaenoic acid (EPA) on stress response, cytokine production, protein metabolism, and immune function after surgery for esophageal cancer. SUMMARY BACKGROUND DATA: It has been reported that safflower oil, rich in n-6 polyunsaturated fatty acid (n-6 PUFA), affects the survival rate of septic animals and decreases the immune function. It has also been reported that the administration of fish oil, in contrast, reduces these stress responses and stress-induced immunosuppression. In humans, the effects of soybean oil emulsion and the administration of EPA on stress response and immune function after surgery have not been established. METHODS: Patients who underwent esophagectomy with thoracotomy were divided into three groups. Seven patients were fed by total parenteral nutrition (TPN) with soybean oil emulsion, which accounted for 20% of total calories. Seven patients were given oral or enteral administration of 1.8 g/day EPA, in addition to TPN with soybean oil emulsion. Nine patients served as the control group; these patients received fat-free TPN. Serum interleukin-6 (IL-6), C-reactive protein, concanavalin A (con A)- or phytohemagglutinin (PHA)-stimulated lymphocyte proliferation, natural killer cell activity, and stress hormones were measured. RESULTS: The postoperative level of serum IL-6 was significantly higher in the group receiving soybean oil emulsion than in the fat-free group. Oral or enteral supplementation of EPA with soybean oil emulsion significantly reduced the level of serum IL-6 compared with the patients receiving soybean oil emulsion. Con A- or PHA-stimulated lymphocyte proliferation decreased significantly on postoperative day 7 in all groups of patients. The supplementation of EPA with soybean oil emulsion significantly improved the lymphocyte proliferation and natural killer cell activity on postoperative day 21 compared with the group receiving soybean oil emulsion. CONCLUSIONS: Soybean oil emulsion amplifies, and the supplementation of EPA reduces, the stress response and stress-induced immunosuppression.  (+info)

Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. (3/4657)

Human UDP-glucuronosyltransferases (UGTs) are expressed in a tissue-specific fashion in hepatic and extrahepatic tissues [Strassburg, Manns and Tukey (1998) J. Biol. Chem. 273, 8719-8726]. Previous work suggests that these enzymes play a protective role in chemical carcinogenesis [Strassburg, Manns and Tukey (1997) Cancer Res. 57, 2979-2985]. In this study, UGT1 and UGT2 gene expression was investigated in human oesophageal epithelium and squamous-cell carcinoma in addition to the characterization of individual UGT isoforms using recombinant protein. UGT mRNA expression was characterized by duplex reverse transcriptase-PCR analysis and revealed the expression of UGT1A7, UGT1A8, UGT1A9 and UGT1A10 mRNAs. UGT1A1, UGT1A3, UGT1A4, UGT1A5 and UGT1A6 transcripts were not detected. UGT2 expression included UGT2B7, UGT2B10 and UGT2B15, but UGT2B4 mRNA was absent. UGT2 mRNA was present at significantly lower levels than UGT1 transcripts. This observation was in agreement with the analysis of catalytic activities in oesophageal microsomal protein, which was characterized by high glucuronidation rates for phenolic xenobiotics, all of which are classical UGT1 substrates. Whereas UGT1A9 was not regulated, differential regulation of UGT1A7 and UGT1A10 mRNA was observed between normal oesophageal epithelium and squamous-cell carcinoma. Expression and analysis in vitro of recombinant UGT1A7, UGT1A9, UGT1A10, UGT2B7 and UGT2B15 demonstrated that UGT1A7, UGT1A9 and UGT1A10 catalysed the glucuronidation of 7-hydroxybenzo(alpha)pyrene, as well as other environmental carcinogens, such as 2-hydroxyamino-1-methyl-6-phenylimidazo-(4, 5-beta)-pyridine. Although UGT1A9 was not regulated in the carcinoma tissue, the five-fold reduction in 7-hydroxybenzo(alpha)pyrene glucuronidation could be attributed to regulation of UGT1A7 and UGT1A10. These data elucidate an individual regulation of human UGT1A and UGT2B genes in human oesophagus and provide evidence for specific catalytic activities of individual human UGT isoforms towards environmental carcinogens that have been implicated in cellular carcinogenesis.  (+info)

Expression of pyrimidine nucleoside phosphorylase mRNA plays an important role in the prognosis of patients with oesophageal cancer. (4/4657)

To clarify the significance of the expression of pyrimidine nucleoside phosphorylase (PyNPase) mRNA as a predictive factor for the prognosis of patients with oesophageal carcinoma, the PyNPase mRNA in the tumours and normal tissues from 55 resected cases of oesophageal carcinoma was examined by a reverse transcription polymerase chain reaction (RT-PCR). As a result, a positive correlation was observed between the tumour/normal (T/N) ratio of the expression of PyNPase mRNA by RT-PCR and that of the enzyme activity of PyNPase based on the findings of an enzyme linked immunosolvent assay (r = 0.594, P = 0.009). The T/N ratio of the expression of PyNPase mRNA was significantly higher in the cases with lymph vessel invasion (P = 0.013), lymph node metastasis (P = 0.0016), and an advanced stage of the disease (P = 0.021) than those without these factors. The patients with a higher T/N ratio of PyNPase mRNA showed significantly worse prognosis than those with a lower T/N ratio (P = 0.023 with log-rank tests). A multivariate analysis for the cumulative survival rates revealed that a high T/N ratio of the expression of PyNPase mRNA was independently related to a poor prognosis. These findings suggested that the determination of PyNPase mRNA by RT-PCR thus appears to be a new useful parameter for identifying both a poor prognosis and a highly malignant potential of oesophageal carcinoma.  (+info)

Differential expression of Hsp27 in normal oesophagus, Barrett's metaplasia and oesophageal adenocarcinomas. (5/4657)

The protein expression patterns of normal, metaplastic and malignant oesophageal tissues were analysed by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) to identify changes associated with Barrett's metaplasia and transformation to oesophageal adenocarcinoma. Heat-shock protein 27 (Hsp27), a small heat-shock protein which is protective against cytotoxic stresses, was abundant in normal oesophagus. However, Hsp27 expression was markedly lower in Barrett's metaplasia and oesophageal adenocarcinomas. This was confirmed by immunohistochemical analysis. Hsp27 protein was most highly expressed in the upper layers of squamous epithelium and exhibited a pattern of expression that corresponded with the degree of squamous maturation. Northern and Southern analysis demonstrated Hsp27 to be regulated at the level of mRNA transcription or abundance. Normal oesophageal tissues were examined for gender differences in Hsp27 expression. Women expressed fourfold higher levels of Hsp27 mRNA, however, this difference was not appreciable in protein expression. Hsp27 protein was inducible by heat shock in Barrett's adenocarcinoma cell lines and an immortalized oesophageal epithelial cell line (HET-1A), but not by oestradiol. These results demonstrate abundant constitutive expression of the stress-response protein Hsp27 in the normal oesophagus, and suggest that low-level expression in Barrett's metaplasia may be one factor which may influence susceptibility to oesophageal adenocarcinoma development.  (+info)

Detection of occult lymph node metastases in esophageal cancer by minimally invasive staging combined with molecular diagnostic techniques. (6/4657)

BACKGROUND AND OBJECTIVES: Lymph node metastases are the most important prognostic factor in patients with esophageal cancer. Histologic examination misses micrometastases in up to 20% of lymph nodes evaluated. In addition, non-invasive imaging modalities are not sensitive enough to detect small lymph nodes metastases. The objective of this study was to investigate the use of reverse transcriptase-polymerase chain reaction (RT-PCR) of messenger RNA (mRNA) for carcinoembryonic antigen (CEA) to increase the detection of micrometastases in lymph nodes from patients with esophageal cancer. METHODS: RT-PCR of CEA mRNA was performed in lymph nodes from patients with malignant and benign esophageal disease. Each specimen was examined histopathologically and by RT-PCR and the results were compared. RESULTS: Metastases were present in 29 of 60 (48%) lymph nodes sample by minimally invasive staging from 13 patients with esophageal cancer when examined histopathologically. RT-PCR identified nodal metastases in 46 of these 60 (77%) samples. RT-PCR detected CEA mRNA in all 29 histologically positive samples and in 17 histologically negative lymph nodes. All lymph nodes from patients with benign disease (n = 15) were negative both histopathologically and by RT-PCR. The stage of two patients was reclassified based on the RT-PCR results, which identified lymph node spread undetected histopathologically. Both of these patients developed recurrent disease after resection of the primary tumor. CONCLUSIONS: RT-PCR is more sensitive than histologic examination in the detection of lymph node metastases in esophageal cancer and can lead to diagnosis of a more advanced stage in some patients. The combination of minimally invasive surgical techniques in combination with new molecular diagnostic techniques may improve our ability to stage cancer patients.  (+info)

G-protein gamma 7 is down-regulated in cancers and associated with p 27kip1-induced growth arrest. (7/4657)

We previously identified and cloned human G protein gamma 7 (G-gamma 7) gene, which is down-regulated in pancreatic cancer. We examined G-gamma 7 expression in other gastrointestinal tract cancers. In 24 of 30 patients with gastrointestinal tract cancer, Northern blot assay and immunohistochemical staining revealed significantly lower G-gamma 7 expression in tumors than in normal tissues from the same patients. Semiquantitative reverse transcription PCRs also showed lower G-gamma 7 expression in tumors than in corresponding normal tissues in 69 of 90 patients. To examine the biological role of G-gamma 7 in cancer, the G-gamma 7 cDNA was transfected into a human esophageal carcinoma cell line, KYSE150, that lacks G-gamma 7 expression. G-gamma 7 expression suppressed cell growth and tritiated-thymidine uptake when cells were confluent G-gamma 7 expression also suppressed tumorigenicity in BALB/c nude mice until 3 weeks after transplantation. G-gamma 7 expression increased the Go/G1 population and decreased the S phase population when cells were at high density. We confirmed that this change was associated with p27K1P1 expression. These findings suggest that human G-gamma 7 is associated with p27kip1-induced growth arrest and may be a therapeutic target in cancers.  (+info)

Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. (8/4657)

BACKGROUND: The causes of adenocarcinomas of the esophagus and gastric cardia are poorly understood. We conducted an epidemiologic investigation of the possible association between gastroesophageal reflux and these tumors. METHODS: We performed a nationwide, population-based, case-control study in Sweden. Case ascertainment was rapid, and all cases were classified uniformly. Information on the subjects' history of gastroesophageal reflux was collected in personal interviews. The odds ratios were calculated by logistic regression, with multivariate adjustment for potentially confounding variables. RESULTS: Of the patients interviewed, the 189 with esophageal adenocarcinoma and the 262 with adenocarcinoma of the cardia constituted 85 percent of the 529 patients in Sweden who were eligible for the study during the period from 1995 through 1997. For comparison, we interviewed 820 control subjects from the general population and 167 patients with esophageal squamous-cell carcinoma. Among persons with recurrent symptoms of reflux, as compared with persons without such symptoms, the odds ratios were 7.7 (95 percent confidence interval, 5.3 to 11.4) for esophageal adenocarcinoma and 2.0 (95 percent confidence interval, 1.4 to 2.9) for adenocarcinoma of the cardia. The more frequent, more severe, and longer-lasting the symptoms of reflux, the greater the risk. Among persons with long-standing and severe symptoms of reflux, the odds ratios were 43.5 (95 percent confidence interval, 18.3 to 103.5) for esophageal adenocarcinoma and 4.4 (95 percent confidence interval, 1.7 to 11.0) for adenocarcinoma of the cardia. The risk of esophageal squamous-cell carcinoma was not associated with reflux (odds ratio, 1.1; 95 percent confidence interval, 0.7 to 1.9). CONCLUSIONS: There is a strong and probably causal relation between gastroesophageal reflux and esophageal adenocarcinoma. The relation between reflux and adenocarcinoma of the gastric cardia is relatively weak.  (+info)

How is Superficial Esophageal Squamous-Cell Carcinoma abbreviated? SESC stands for Superficial Esophageal Squamous-Cell Carcinoma. SESC is defined as Superficial Esophageal Squamous-Cell Carcinoma very rarely.
Radiotherapy has played a limited role for the treatment of human esophageal cancer owing to the risk of tumor radioresistance. Core 1 β1, 3-galactosyltransferase (C1GalT1), which catalyzes the formation of core 1 O-glycan structures, is frequently overexpressed during tumorigenesis. However, the exact effects and mechanisms of C1GalT1 in the radioresistance of esophageal cancer remain unclear. In this study, Public databases and our data revealed that C1GalT1 expression was up-regulated in esophageal cancer tissues and was associated with poor survival. Upon irradiation, we found that esophageal cancer cells with high levels of C1GalT1 could tolerate cell death and had increased resistance to radiotherapy. Irradiation also promoted the expression of C1GalT1 and core 1 O-glycan structures. C1GalT1 knockdown increased the radiosensitivity of esophageal cancer cells, and attenuated irradiation-enhanced migration and invasion. Mechanistic investigations showed that C1GalT1 modified O-glycan ...
To determine the expression of nucleostemin (NS), epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) mRNA in human esophageal squamous cell carcinoma (ESCC) tissues and their association in a human ESCC cell line. The expression of NS, EGF and EGFR mRNA was determined in paired normal esophageal and ESCC tissues of 62 patients using in situ hybridization. The association between NS and EGF or EGFR was examined using immunoblotting and real time polymerase chain reaction in a human ESCC cell line transfected with NS siRNA or treated with a selective EGFR inhibitor. In normal esophageal and ESCC tissues, the positive detection rates were 21.0% (13/62) and 69.4% (43/62) for NS mRNA staining, 40.3% (25/62) and 77.4% (48/62) for EGF mRNA staining, and 30.6% (19/62) and 75.8% (41/62) for EGFR mRNA staining, respectively. These results indicated that NS, EGF and EGFR mRNA expression was upregulated mostly in ESCC tissues. Moreover, the expression of NS, EGF and EGFR mRNA was ...
Health care professionals may find information about advanced esophageal squamous cell carcinoma (ESCC) and KEYTRUDA® (pembrolizumab).
Figure 7. Quantitative real‑time PCR and western blot analysis were used to - ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity.
TY - CONF. T1 - Molecular pathogenesis of human esophageal squamous cell carcinomas. AU - Tang, Cheuk On. AU - Hu, Y.C.. AU - Law, B.F.. AU - Wong, K.Y.. AU - Hu, L.. AU - Guan, X.Y.. AU - Srivastava, G.. PY - 2002. Y1 - 2002. M3 - Conference presentation (not published in journal/proceeding/book). T2 - Hong Kong International Cancer Congress. Y2 - 1 January 2002. ER - ...
Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in developing countries, especially in Eastern Asia [ 1 ].
Gong, Jifang.,Zhang, Xiaodong.,Lu, Ming.,Li, Yan.,Li, Jie.,...&Shen, Lin.(2013).Efficacy of paclitaxel plus cisplatin in advanced esophageal squamous cell cancer: Further analysis of single center, prospective study..JOURNAL OF CLINICAL ONCOLOGY,suppl.S(15 ...
Oesophageal cancer is a malignant and aggressive disease with very poor survival. The aim of this thesis was to evaluate novel therapeutic targets in oesophageal cancer.. In paper I, Hsp90 was expressed in all 81 oesophageal cancer tissues and also in nine oesophageal cancer cell lines. A specific Hsp90 inhibitor, 17-AAG, could efficiently inhibit cell proliferation, cell survival and sensitise oesophageal cancer cells to gamma photon irradiation. By inhibition of Hsp90 using 17-AAG, EGFR- and IGF-1R-mediated signalling was downregulated.. In paper II, tumour samples from 80 oesophageal cancer patients were investigated for the expression of EGFR and LRIG1-3. Based on a total score of intensity and expression fraction a trend towards survival differences was found for LRIG2 (p=0.18) and EGFR (p=0.09). Correlation analysis revealed a correlation between expression of EGFR and LRIG3 (p=0.0007). Significant correlations were found between LRIG1 mRNA expression levels and sensitivity to cisplatin (r ...
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide. MicroRNA (miRNA)‑544 is an important cancer‑associated RNA that is downregulated in multiple types of cancer. However, the role of miR‑544 in ESCC progression remains unknown. In the present study, miR‑544 expression level was determined via RT‑qPCR in 30 pairs of ESCC and adjacent normal tissues and in a panel of ESCC cell lines. Cell proliferation and cell apoptosis were assessed by MTT and flow cytometry assays. Luciferase reporter assay and western blot analysis were conducted to verify E2F transcription factor 5 (E2F5), an oncogene in ESCC, as a novel target gene of miR‑544. The results illustrated that miR‑544 is frequently downregulated in ESCC tissues and cell lines. Overexpression of miR‑544 in ESCC cells resulted in decreased cell proliferation and increased cell apoptosis. Thus, E2F5 was identified as a target of miR‑544, and its expression was negatively correlated with ...
Evasion of apoptosis is a major contributing factor to the development of chemo- and radiotherapy resistance. Therefore, activation of non-apoptotic programmed cell death (PCD) could be an effective alternative against apoptosis-resistant cancers. In this study, we demonstrated in vitro and in vivo that metformin can induce pyroptosis, a non-apoptotic PCD, in esophageal squamous cell carcinoma (ESCC), a commonly known chemo-refractory cancer, especially at its advanced stages. Proline-, glutamic acid- and leucine-rich protein-1 (PELP1) is a scaffolding oncogene and upregulated PELP1 in advanced stages of ESCC is highly associated with cancer progression and patient outcomes. Intriguingly, metformin treatment leads to gasdermin D (GSDMD)-mediated pyroptosis, which is abrogated by forced expression of PELP1. Mechanistically, metformin induces pyroptosis of ESCC by targeting miR-497/PELP1 axis. Our findings suggest that metformin and any other pyroptosis-inducing reagents could serve as alternative
High levels of angiogenesis are associated with poor prognosis and a highly invasive phenotype in esophageal squamous carcinoma. and significantly decreased NF-B signaling pathway. This study suggests that CCR7 plays WZ8040 an important pro-angiogenic role in esophageal squamous carcinoma via a mechanism linked to activation of the NF-B pathway; CCR7 may represent a potential target for anti-angiogenic therapy in esophageal squamous carcinoma. Keywords: CCR7, esophageal squamous carcinoma, angiogenesis, VEGF Introduction Esophageal squamous cell carcinoma (ESCC) is usually one of the most aggressive tumors and is usually also the most common cause of esophagus malignancy deaths WZ8040 worldwide [1]. Most of individuals showing with ESCC are diagnosed with advanced disease, due to the late emergence of clinical symptoms. In particular, the presence of regional attack, distant metastasis and tumor-induced angiogenesis show highly malignant potential in esophageal carcinoma patients [2]. Although ...
High levels of angiogenesis are associated with poor prognosis and a highly invasive phenotype in esophageal squamous carcinoma. and significantly decreased NF-B signaling pathway. This study suggests that CCR7 plays WZ8040 an important pro-angiogenic role in esophageal squamous carcinoma via a mechanism linked to activation of the NF-B pathway; CCR7 may represent a potential target for anti-angiogenic therapy in esophageal squamous carcinoma. Keywords: CCR7, esophageal squamous carcinoma, angiogenesis, VEGF Introduction Esophageal squamous cell carcinoma (ESCC) is usually one of the most aggressive tumors and is usually also the most common cause of esophagus malignancy deaths WZ8040 worldwide [1]. Most of individuals showing with ESCC are diagnosed with advanced disease, due to the late emergence of clinical symptoms. In particular, the presence of regional attack, distant metastasis and tumor-induced angiogenesis show highly malignant potential in esophageal carcinoma patients [2]. Although ...
We have mapped binding sites for the histone demethylase, JMJD2C/KDM4C/GASC1, and the effect of JMJD2C depletion on H3K9me3 and H3K36me3 distributions in KYSE150 cells. The human esophageal carcinoma cell line, KYSE150, contains an amplification of the JMJD2C locus. ChIP-seq was performed using chromatin from control or JMJD2C-depleted KYSE150 cells and antibodies recognizing JMJD2C, H3K4me3, H3K9me3 or H3K36me3.
Esophageal Neoplasms; Cancer of Esophagus; Esophageal Cancer. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
p?=?0.035). 35 (60.3%) and 18 sufferers (31%) experienced quality 1C2 SNX-2112 or 3C4 toxicity, respectively (CTCAE v4.0). Bottom line: Radiochemotherapy in older sufferers is normally a feasible treatment and its own outcome is normally close to youthful sufferers outcome released in the books. Operative resection, after extensive geriatric assessment, ought to be suggested as the typical treatment for adenocarcinoma of lower esophagus or gastroesophageal junction in older sufferers with great PS and low co-morbidity profile, since it is in youthful sufferers. Keywords: esophageal neoplasm, older sufferers, radiotherapy, chemoradiotherapy, esophagectomy Launch Esophageal cancers (OC) may be the 8th most common cancers world-wide, with 481,000 brand-new situations (3.8% of the full total) approximated in 2008, as well as the sixth most common reason behind loss of life from cancer with 406,000 fatalities (5.4% of the full total) (1). Generally in most traditional western countries, squamous cell ...
Dr Sarah Thompson, a surgeon and PhD candidate, says tiny cancer cells are being missed in routine pathology examinations, resulting in half of patients who have been given the all-clear dying within five years.. In a study of 250 oesophageal cancer patients in Adelaide over the past 10 years, Dr Thompson found that of the 119 people given a clean bill of health, only 62 were still alive five years later.. If you tell people they are totally clear of cancer and then a year later they come back with secondary cancer, that is a devastating result, she says.. More than 1000 people are diagnosed with cancer of the oesophagus in Australia each year. There are two types: squamous cell carcinoma, occurring in the top part of the oesophagus; and adenocarcinoma, which is closer to the stomach. The latter has increased by 400% in Australia since the 1970s.. Dr Thompsons study showed that oesophageal tumour cells are being missed in the lymph nodes in conventional pathological tests.. Pathologists ...
Esophageal cancer is one of the most lethal human cancers that occur worldwide. It is the eighth most common cancer in several European countries and its incidence is on the increase in Western countries (1-3). Barretts esophagus, the only known precursor to esophageal adenocarcinoma, is prevalent in Western countries (1-3). In Barretts esophagus, a human metaplastic condition is characterized by a posterior intestinal-like phenotype in an anterior organ. Underlying it is a mechanism of epigenetically regulated, developmentally critical genes, such as the HOXB family (4). By contrast, the squamous cell carcinoma of the esophagus is predominant in Asia, including Japan (1-3).. A previous study suggested that the genetic and epigenetic alterations, which constrain tumor suppressor genes and activate oncogenes, are involved in the initiation, progression and development of carcinogenesis in the esophagus, which is asssociated with exposure to environmental carcinogens (5). Specifically, animal ...
Although several molecular alterations were identified, esophageal cancers still represent a major challenge of interdisciplinary oncology [24]. Among of which, STAT3 signaling pathway is particular an important one. STAT3 always play a critical role in oncogenic signaling in the carcinogenesis and progression of several cancers. In normal cells, STAT3 expression and activity is under tight control to ensure physiological cell proliferation, survival, differentiation and motility. For esophageal cancer, constitutively activated STAT3 expression was found in both esophageal squamous cell carcinomas (ESCC) and Barretts adenocarcinomas (BAC) [25]. While, the mechanisms involved in its activation remain to be further identified. Excepts for the potential STAT3 gene amplification on chromosome 17q21, a region frequently amplified in esophageal adenocarcinomas [26], inflammation-associated STAT3 activation is also conceivable, at least in vivo [27]. In this paper, we found another way mediated the ...
Members of the Prenylated Rab acceptor domain family (PRAF) are essential for the regulation of many cellular processes [22, 23]. Here we have demonstrated that PRAF3 could induce apoptosis and inhibit migration and invasion of ESCC cells and hence may serve as a tumor suppressor in ESCC.. Although the role of PRAF3 has been studied in several other tumors using tumor cell lines [7, 9, 10, 24], there is a lack of investigation into the relationship between PRAF3 expression and the clinical features of ESCCs. In the present study, we found that the expression level of PRAF3 mRNA and protein in ESCC tissues was significantly lower than that in the matched normal tissues. In addition, we found that down-regulation of PRAF3 expression was significantly correlated with poorly differentiated grading, advanced tumor stage and lymph node metastasis of ESCC. These results would imply that PRAF3 may play an important role in regulating the progression and metastasis of ESCCs, although further in vivo ...
TY - JOUR. T1 - THUMP domain containing 2 protein possibly induces resistance to cisplatin and 5-fluorouracil in in vitro human esophageal squamous cell carcinoma cells as revealed by transposon activation mutagenesis. AU - Hayashi, Masato. AU - Kawakubo, Hirofumi. AU - Fukuda, Kazumasa. AU - Mayanagi, Shuhei. AU - Nakamura, Rieko. AU - Suda, Koichi. AU - Hayashida, Testu. AU - Wada, Norihito. AU - Kitagawa, Yuko. PY - 2019/12/1. Y1 - 2019/12/1. N2 - Background: Although chemotherapy is a core treatment for esophageal cancer, some patients develop drug resistance. Gene screening with transposons (i.e. mobile genetic elements) is a novel procedure for identifying chemotherapy-resistant genes. Transposon insertion can randomly affect nearby gene expression. By identifying the affected genes, candidate genes can be found. The present study aimed to identify cisplatin (CDDP)/5-fluorouracil (5-FU)-resistant genes in in vitro human esophageal squamous cell carcinoma with transposons. Methods: After ...
TY - JOUR. T1 - THUMP domain containing 2 protein possibly induces resistance to cisplatin and 5-fluorouracil in in vitro human esophageal squamous cell carcinoma cells as revealed by transposon activation mutagenesis. AU - Hayashi, Masato. AU - Kawakubo, Hirofumi. AU - Fukuda, Kazumasa. AU - Mayanagi, Shuhei. AU - Nakamura, Rieko. AU - Suda, Koichi. AU - Hayashida, Testu. AU - Wada, Norihito. AU - Kitagawa, Yuko. PY - 2019/12/1. Y1 - 2019/12/1. N2 - Background: Although chemotherapy is a core treatment for esophageal cancer, some patients develop drug resistance. Gene screening with transposons (i.e. mobile genetic elements) is a novel procedure for identifying chemotherapy-resistant genes. Transposon insertion can randomly affect nearby gene expression. By identifying the affected genes, candidate genes can be found. The present study aimed to identify cisplatin (CDDP)/5-fluorouracil (5-FU)-resistant genes in in vitro human esophageal squamous cell carcinoma with transposons. Methods: After ...
Gupta VK, Park JO, Jaskowiak NT, Mauceri HJ, Seetharam S, Weichselbaum RR, Posner MC. Combined gene therapy and ionizing radiation is a novel approach to treat human esophageal adenocarcinoma. Ann Surg Oncol. 2002 Jun; 9(5):500-4 ...
Background: China is a high incidence area of esophageal cancer. Esophageal squamous cell carcinoma recurrence and mortality rates are relatively high. Recent studies show that the recurrence rate remains very high even through the implementation of lymph node expanding dissection. Methods and Results: In order to study the relationship between lymph node dissection number and survival of the patients with esophageal squamous cell carcinoma, 407 cases of esophageal cancer are selected in the First Affiliated Hospital of Xian Jiaotong University from January 2009 to June 2013. There were 15 cases without surgery, while the rest of the 392 patients were post-operation in follow-up. 54 patients were lost in follow-up, and the rate was 13.8%. Finally, there were 338 patients entered into our research. The median age was 58 (37 - 81), males accounted for 79%. The number of lymph node dissection is for a total of 2091, and a median of 5. Positive lymph nodes are 400, while the total positive rate is 19.1%.
Human esophageal squamous cell carcinoma exhibits a reduced degree of differentiation, as evidenced by the decreased capacity to form cross-linked envelopes, thus suggesting that these tumor cells frequently display a defect in the terminal differentiation pathway (3) . Involucrin is a major component of the cornified envelope and is considered to be an appropriate marker for terminal differentiation. The results described above demonstrate that adenovirus-mediated transfer of the p21sdi1 gene up-regulates involucrin protein expression and induces terminal differentiation in human esophageal squamous cell carcinoma cells, thereby leading to sequential apoptotic cell death.. Adenovirus-mediated gene transfer is a highly efficient gene delivery system. We used a recombinant adenovirus to overexpress p21sdi1 in normal and neoplastic squamous cells. Preliminary titration studies showed that transient transgene expression in most populations of infected cells can be expected at an MOI of 100. In ...
TY - JOUR. T1 - Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas. AU - Toh, Y.. AU - Kuwano, H.. AU - Mori, M.. AU - Nicolson, G. L.. AU - Sugimachi, K.. PY - 1999/1/1. Y1 - 1999/1/1. N2 - The MTA1 gene is a recently identified novel candidate breast cancer metastasis-associated gene which has been implicated in the signal transduction or regulation of gene expression. We examined the mRNA expression levels of the MTA1, the human homologue of the rat mta1 gene in 47 surgically resected oesophageal squamous cell carcinomas by quantitative reverse transcription polymerase chain reaction. The relative overexpression of MTA1 mRNA (tumour/normal ratio ≥ 2) was observed in 16 out of 47 (34.0%) oesophageal carcinomas. Oesophageal tumours overexpressing MTA1 mRNA (T/N ratio ≥ 2) showed significantly higher frequencies of adventitial invasion (P , 0.05) and lymph node metastasis (P , 0.05), and tended to have a higher rate of lymphatic involvement than the ...
Background The expression of Fos-related antigen 1 (Fra-1) affects tumor progression, migration, and invasion. In this study, we identified the genes regulated by Fra-1 in esophageal squamous cell...
Gong ling Cao is also known as blushred rabdosia. The sweet, bitter and cold herb has been used in TCM to treat chronic bronchitis, chronic inflammation of the pelvic area, swelling of throat, insect bites and snake bites as it clears heat and toxins, nourish yin, remove blood stasis and relieves pain by enhancing the functions of stomach, lung and liver channels. In vitro, researcher found that Gong ling Cao has cytotxicity activity against CaEs-17 human esophageal cancer cell line, at 2 and 3ug/ml, the inhibiting rates were 40% and 75%. Can it be used effective against endometrial cancer? Further studies is needed ...
What should we use as medium for cryopreservation of human esophageal cancer cell line - FBS with 10% DMSO OR its own medium with 10% DMSO ...
TY - JOUR. T1 - Oxaliplatin induces mitotic catastrophe and apoptosis in esophageal cancer cells. AU - Ngan, Chew Yee. AU - Yamamoto, Hirofumi. AU - Takagi, Akimitsu. AU - Fujie, Yujiro. AU - Takemasa, Ichiro. AU - Ikeda, Masataka. AU - Takahashi-Yanaga, Fumi. AU - Sasaguri, Toshiyuki. AU - Sekimoto, Mitsugu. AU - Matsuura, Nariaki. AU - Monden, Morito. PY - 2008/1/1. Y1 - 2008/1/1. N2 - The platinum-based chemotherapeutic agent oxaliplatin displays a wide range of antitumor activities. However, the underlying molecular responses to oxaliplatin in esophageal cancer remain largely unknown. In the present study, we investigated the effect of oxaliplatin on two esophageal cancer cell lines, squamous cell carcinoma (TE3) and adenocarcinoma (TE7). Following cell-cycle arrest at G2 phase after oxaliplatin treatment, TE3 cells died via apoptosis and TE7 cells died via mitotic catastrophe. Survivin was inhibited more in TE7 cells compared with TE3 cells, but inhibition of survivin using small ...
TY - JOUR. T1 - Aberrant methylation of the Ras-related Associated with Diabetes gene in human primary esophageal cancer. AU - Jin, Zhe. AU - Feng, Xianling. AU - Jian, Qianhe. AU - Cheng, Yulan. AU - Gao, Yan. AU - Zhang, Xiaojing. AU - Wang, Liang. AU - Zhang, Yuan. AU - Huang, Weiling. AU - Fan, Xinmin. AU - Chen, Si. AU - Yu, Huimin. AU - Zhao, Zhenfu. AU - Dong, Ming. AU - Liu, Jie. AU - Mori, Yuriko. AU - Meltzer, Stephen. PY - 2013/11. Y1 - 2013/11. N2 - Background/Aim: Ras-related associated with diabetes (RRAD), a member of the Ras-related GTPase superfamily, is frequently methylated in several human cancers, though its methylation profile remains unclear in esophageal cancer. Materials and Methods: We examined RRAD promoter hypermethylation using real-time quantitative methylation-specific PCR in 229 primary human esophageal tissues of contrasting histological types. Results: RRAD hypermethylation showed highly discriminative receiver-operator characteristic curve profiles, clearly ...
Background: Evidence is scarce for the effectiveness of therapies for oesophageal cancer progressing after chemotherapy, and no randomised trials have been reported. We aimed to compare gefitinib with placebo in previously treated advanced oesophageal cancer. Methods: For this phase 3, parallel, randomised, placebo-controlled trial, eligible patients were adults with advanced oesophageal cancer or type I/II Siewert junctional tumours, histologically confirmed squamous-cell carcinoma or adenocarcinoma, who had progressed after chemotherapy, with WHO performance status 0-2, and with measurable or evaluable disease on CT scan. Participants were recruited from 48 UK centres and randomly assigned (1:1) to gefitinib (500 mg) or matching placebo by simple randomisation with no stratification factors. Patients, clinicians, and trial office staff were masked to treatment allocation. Treatment continued until disease progression, unacceptable toxicity, or patient choice. The primary outcome was overall survival,
Esophageal carcinoma is a malignancy that severely threatens human health, with a high incidence rate and a low 5‑year survival rate. Resistance to chemotherapy frequently emerges during its treatment, partly due to the induction of autophagy. Therefore, targeting autophagy may be a promising therapeutic approach for the treatment of esophageal carcinoma. In the present study, it was investigated how chloroquine (CQ) can influence the growth ability and biological behaviors of EC109 esophageal squamous carcinoma cells in vitro, as well as the potential molecular mechanisms behind its activity. It was demonstrated that CQ could suppress the growth and proliferation of EC109 cells in a time‑ and dose‑dependent manner; migration and colony formation abilities were also inhibited by CQ. Furthermore, subsequent to the exposure to CQ, the number of autophagosomes was clearly increased in EC109 cells overexpressing green fluorescent protein tagged‑light chain (LC)3 when observed by fluorescence ...
Radiation therapy alone is as effective in decreasing swallowing complications experienced by advanced esophageal cancer patients as RT combined with chemotherapy, thus allowing patients to forgo chemotherapy, according to research presented today at the American Society for Radiation Oncologys 56th Annual Meeting.
A study was undertaken to attempt to relate the distribution of exogenous factors to the varying incidences of esophageal cancer in the Caspian Littoral of Iran. For the study, 38 villages were chosen by random sampling in 14 regions defined by their esophageal cancer incidence and environmental characteristics. Information was obtained on the dietary, social, and cultural features of each village. In addition, an extensive 5-day study of 6 randomly selected households in each of the 38 villages was conducted. The study consisted of measured dietary intake, a historical food consumption questionnaire, and clinical examinations of adult occupants.. Preliminary results show no single factor responsible for the etiology of esophageal cancer. However, there were some major dietary differences between the regions of different esophageal cancer risk. Bread was the chief staple food in high-incidence areas; rice, in low-incidence areas. In high-incidence areas, there was a low intake of vitamins A and ...
is key for effective targeted therapies.. by Rosa Moreno-Hanson, PhD. The incidence of esophageal cancer in the USA is markedly demarcated by gender and race. The incidence is greater in men, and the predominance of specific esophageal cancer subtypes differs among Caucasians and African Americans. Two main subtypes of esophageal cancer are recognized based on tissue analysis: esophageal squamous cell carcinoma (ESCC, more common in African Americans), and esophageal adenocarcinoma (EAC, more common in Caucasians). The upper and mid-esophagus are predominantly affected by ESCC1. Consumption of alcohol and use of tobacco are considered major risk factors for developing ESCC. Combined use of alcohol and tobacco is known to further augment the risk for developing ESCC. This is due to the compounding effect of alcohol as an irritant of the esophageal tissue and tobacco as the source of carcinogens2. Currently, EAC represents the predominant subtype in the USA; 80% of all cases of esophageal cancer ...
The effect of tobacco smoking and alcohol drinking on esophageal cancer (EC) has never been explored in Spain where black tobacco and wine consumptions are quite prevalent. We estimated the independent effect of different alcoholic beverages and type of tobacco smoking on the risk of EC and its main histological cell type (squamous cell carcinoma) in a hospital-based case-control study in a Mediterranean area of Spain. We only included incident cases with histologically confirmed EC (n = 202). Controls were frequency-matched to cases by age, sex and province (n = 455). Information on risk factors was elicited by trained interviewers using structured questionnaires. Multiple logistic regression was used to estimate adjusted odds ratios and 95% confidence intervals (CI). Alcohol drinking and tobacco smoking were strong and independent risk factors for esophageal cancer. Alcohol was a potent risk factor with a clear dose-response relationship, particularly for esophageal squamous-cell cancer. Compared to
Benign esophageal tumor: Find the most comprehensive real-world symptom and treatment data on benign esophageal tumor at PatientsLikeMe. 2 patients with benign esophageal tumor experience fatigue, insomnia, depressed mood, pain, and anxious mood and use Milnacipran and Oxycodone ER to treat their benign esophageal tumor and its symptoms.
Purpose: We previously revealed that the calreticulin (CRT) gene is a candidate oncogene promoting cell migration and invasion and that neuropilin-1 (NRP1) is a possible effector downstream of CRT in esophageal squamous carcinoma cells. This study aims to explore the mechanisms underlying the migration and invasion of esophageal cancer cells regulated by CRT through NRP1.. Experimental Design: Quantitative reverse-transcription polymerase chain reaction, Western blot analysis, chromatin immunoprecipitation, and reporter gene assays were used to investigate the relationship between CRT and NRP1. In vitro and in vivo assays were carried out to evaluate the effects of NRP1 on malignant phenotypes of ESCC cells and tumor metastasis in NOD/SCID mice. Immunohistochemistry was performed to analyze the expression of CRT and NRP1 in esophageal squamous cell carcinomas (ESCC).. Results: Knockdown of CRT decreased the expression of NRP1. Inhibition of NRP1 reduced ESCC cell motility in vitro and ...
Esophageal cancer is cancer arising from the esophagus-the food pipe that runs between the throat and the stomach. Symptoms often include difficulty in swallowing and weight loss. Other symptoms may include pain when swallowing, a hoarse voice, enlarged lymph nodes (glands) around the collarbone, a dry cough, and possibly coughing up or vomiting blood. The two main sub-types of the disease are esophageal squamous-cell carcinoma (often abbreviated to ESCC), which is more common in the developing world, and esophageal adenocarcinoma (EAC), which is more common in the developed world. A number of less common types also occur. Squamous-cell carcinoma arises from the epithelial cells that line the esophagus. Adenocarcinoma arises from glandular cells present in the lower third of the esophagus, often where they have already transformed to intestinal cell type (a condition known as Barretts esophagus). Causes of the squamous-cell type include tobacco, alcohol, very hot drinks, poor diet, and ...
1. Yang J, Liu X, Cao S, Dong X, Rao S, Cai K. Understanding Esophageal Cancer: The Challenges and Opportunities for the Next Decade. Front Oncol. 2020;10:1727 2. Thrift AP. Global burden and epidemiology of Barrett oesophagus and oesophageal cancer. Nat Rev Gastroenterol Hepatol. 2021 3. Then EO, Lopez M, Saleem S, Gayam V, Sunkara T, Culliford A. et al. Esophageal Cancer: An Updated Surveillance Epidemiology and End Results Database Analysis. World J Oncol. 2020;11:55-64 4. Demarest CT, Chang AC. The Landmark Series: Multimodal Therapy for Esophageal Cancer. Ann Surg Oncol. 2021 5. Reichenbach ZW, Murray MG, Saxena R, Farkas D, Karassik EG, Klochkova A. et al. Clinical and translational advances in esophageal squamous cell carcinoma. Adv Cancer Res. 2019;144:95-135 6. Li Y, Li Y, Chen X. NOTCH and Esophageal Squamous Cell Carcinoma. Adv Exp Med Biol. 2021;1287:59-68 7. Christopoulos PF, Gjolberg TT, Kruger S, Haraldsen G, Andersen JT, Sundlisaeter E. Targeting the Notch Signaling Pathway in ...
To assess the relative risk of esophageal cancer associated with osteoporosis study drugs (alendronate, etidronate, ibandronate, risedronate, and raloxifene), initiators of osteoporosis drugs and non-initiators (comparators, women sharing match criteria with the initiator) entered an inception cohort for every three-month period, beginning in the first quarter of 1996. Assignment to study drug exposure group remained fixed from the start of follow-up, analogous to an intent-to-treat analysis. The risk of esophageal cancer among initiators of study drug compared to non-initiators of study drug was estimated through calculation of a hazard ratio. For calculation of 721+ day hazard ratios, only esophageal cancer cases occurring at least 721 days from initiation of study drug were used. For calculation of 1441+ day hazard ratios, only esophageal cancer cases occurring at least 1441 days from initiation of study drug were used ...
Esophageal cancer is a devastating, but potentially preventable, disease. The catch is that by the time that symptoms occur, the cancer has often progressed too far to allow cure.. So what is a person to do who would like to avoid this cancer? The best thing is to know the risk factors. Longterm heartburn is a strong risk factor. Smoking, male gender, and obesity also figure into your risk for this disease. If you have two or more of these risk factors, have a conversation with your primary care doctor. You may need a screening upper endoscopy - a simple test where we put a light tube with a camera down your esophagus (or food tube) to make sure that you dont have a precancerous or cancerous changes in your esophagus.. So ask your doctor. A few minutes could literally save a life.. Dr. Shaheen is a paid consultant to Cook Medical regarding the research and development of medical devices.. ...
Background: Oesophageal squamous cell carcinoma (OSCC) is a common cancer worldwide and has a very high mortality rate. Squamous dysplasia is the precursor lesion for OSCC and it can be seen during routine endoscopy with Lugols iodine staining. We aimed to examine the risk factors for squamous dysplasia and determine if a risk model could be constructed which would be useful in selecting apparently healthy subjects for endoscopic screening in a high risk population in Linzhou, Peoples Republic of China.. Subjects and methods: In this cross sectional study, 724 adult volunteers aged 40-65 years were enrolled. All subjects completed a questionnaire regarding potential environmental exposures, received physical and dental examinations, and underwent upper endoscopy with Lugols iodine staining and biopsy. Subjects were categorised as having or not having histologically proven squamous dysplasia/early cancer. Risk factors for dysplasia were examined using univariate and multivariate logistic ...
TY - JOUR. T1 - Expression and up-regulation of interleukin-6 in oesophageal carcinoma cells by n-sodium butyrate. AU - Wang, L. S.. AU - Chow, K. C.. AU - Wu, C. W.. PY - 1999. Y1 - 1999. N2 - Recently, the serum level of interleukin (IL)-6 has been shown to correlate with disease progression and prognosis of cancer patients. However, the available information about the source and the pathophysiological regulation of IL-6 in cancer cells is limited. Thus, in this study, we tried to identify the source and the clinical roles of serum IL-6 in patients with cesophageal squamous cell carcinoma (ESCC), and then further to characterize the biological regulation of IL-6 in ESCC cell lines. Sera and tissue specimens from 80 consecutive patients with ESCC were collected between 1993 and 1997. Additionally, three ESCC cell lines were used for in vitro study. The concentration of serum IL-6 was measured by enzyme-linked immunosorbent assay (ELISA), and correlated the survival time with measured IL-6 ...
Objective: As a common malignant tumor, esophageal carcinoma lacked specific clinical symptoms, leading to distal metastasis at terminal stage. Cispla..
Leukotriene B4 (LTB4R and LTB4R2) and cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2) contribute to malignant cell transformation. We aimed to investigate the expression of LTB4R, LTB4R2, CYSLTR1 and CYSLTR2 in esophageal squamous cell carcinoma and adjacent non-transformed squamous epithelium of the esophagus, as well as in control biopsy samples from esophageal squamous epithelium of patients with functional dyspepsia. Expression of LTB4R, LTB4R2, CYSLTR1 and CYSLTR2 was analyzed by immunohistochemistry (IHC) and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in biopsy samples of 19 patients with esophageal squamous cell cancer and 9 sex- and age-matched patients with functional dyspepsia. LTB4R, LTB4R2, CYSLTR1 and CYSLTR2 were expressed in all biopsy samples. Major findings were: 1) protein levels of all leukotriene receptors were significantly increased in esophageal squamous cell cancer compared to control mucosa (p | 0.05); 2) CYSLTR1 and CYSLTR2 gene expression was
AIM: To investigate the putative role of human papillomavirus (HPV) infection in the carcinogenesis of esophageal squamous cell carcinoma in China.. METHODS: Twenty-three esophageal squamous cell carcinoma samples and the distal normal epithelium from Shanxi Province, and 25 more esophageal squamous cell carcinoma samples from Anyang city, two areas with a high incidence of esophageal cancer in China, were detected for the existence of HPV-16 DNA by PCR, mRNA in situ hybridization (ISH) and immunohistochemistry (IHC) targeting HPV-16 E6 gene.. RESULTS: There were approximately 64% (31/48) patients having HPV-16 DNA in tumor samples, among them nearly two-thirds (19/31) samples were detected with mRNA expression of HPV-16 E6. However, in the normal esophageal epithelium from cancer patients, the DNA and mRNA of HPV-16 were found with much less rate: 34.7% (8/23) and 26.1% (6/23) respectively. In addition, at protein level detected by IHC assay, 27.1% (13/48) tumor samples had virus oncoprotein E6 ...
Esophageal squamous cell carcinoma (ESCC) and esophagogastric junction adenocarcinoma (EGJA) will be the two primary types of gastrointestinal cancers that pose an enormous threat to individual health. tumor-linked autoantibody biomarkers in esophageal squamous cellular carcinoma reported in several research. Mmp-7: Matrix metallopeptidase 7; Hsp70: Heat shock proteins 70; PRDX 6: Peroxiredoxin 6; Bmi-1: BMI1 proto-oncogene, polycomb band finger; FG-4592 supplier Koc: Insulin-like growth aspect 2 mRNA binding proteins 3; C-Myc: MYC proto-oncogene, bHLH transcription aspect; IMP1: Insulin-like development aspect 2 mRNA binding proteins 1. The many comprehensively investigated TA autoantibodies in ESCC have already been p53 autoantibodies accompanied by autoantibodies against P16 and c-Myc. Provided the prominent feature of p53 in cancers it isnt unexpected that may be the most broadly studied autoantibody in ESCC. Autoantibodies against p53 in the medical diagnosis of ESCC have already been ...
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Subject:Biomedical Cancer study Question:The search for genomic-wide, micro-RNA and epigenetics interactions in Esophageal Squamous Cell Carcinoma. Thesis statement (Main idea of literature review): The cause of Esophageal Squamous Cell Carcinoma is mainly relates to Genomic-wide (3 Joint) .. Although Micro-RNA may have influences on it, the surveys on it are lack of reasonable control (quantities, same living environment and habitat), and there is no enough evidence shows Micro RNA can cause it directly.. The environment can raise the risk of ESCC ( Epi-genetics) , especially diet.. For a custom paper on the above, place your Order Now!!. What We Offer: ...
The advantage of left transthoracic esophagectomy is readily apparent in that it affords a surgical resection with a single incision. In addition to the obvious advantage of decreasing the patients discomfort, the left transthoracic esophagectomy also can be performed in much less time than the Ivor Lewis or McKeown esophagectomy, with operative time averaging 2 to 3 hours.6 The left transthoracic approach does have a number of disadvantages that should be noted. First, although the division of the diaphragm provides excellent visualization of the left upper quadrant of the abdomen via the left chest, the remainder of the abdomen cannot be accessed using this approach. As a result of the limited abdominal exposure, adequate dissection of the pylorus cannot be achieved to perform pyloromyotomy. Many surgeons profess that gastric drainage is an essential component of esophageal reconstruction with gastric conduit placement after esophagectomy and identify the inability to perform a drainage ...
Dysregulations of the mevalonate pathway (MVA) have been previously identified. Our previous study demonstrated that 3‑hydroxy‑3‑methylglutaryl‑coenzyme A reductase (HMGCR), the rate‑limiting enzyme of the MVA pathway, was upregulated in esophageal squamous cell carcinoma (ESCC) and statin‑inhibited ESCC tumorigenesis. However, the underlying mechanism of HMGCR regulation in ESCC remains unknown. In the present study, western blotting and immunohistochemistry analysis demonstrated that sterol regulatory element‑binding protein 2 (SREBP2), the master regulator for HMGCR, was upregulated in ESCC clinical samples. Overexpression of SREBP2 expression in ESCC cell lines promoted the growth, migration and colony formation of cancer cells in the MTT, Boyden chamber and soft agar assays, respectively, which was inhibited by lovastatin. Downregulation of SREBP2 expression in ESCC cell lines inhibited the viability, and migration and colony formation abilities of cancer cells. Assessment of ...
BACKGROUND:Germline mutations of BRCA2 have been reported in various malignancies. We investigated BRCA2 germline mutations in familial clusters with esophageal squamous cell carcinoma (ESCC). MATERIAL AND METHODS:We screened the DNA of familial ESCC patients for BRCA2 germline mutations with whole gene sequencing. Multiple BRCA2 mutations including one novel splice variant, c.426-2A|G were identified. Other family members, sporadic ESCC patients, and controls were also assessed for the novel mutation. RESULTS:The mutation c.426-2A|G was found in 2 affected ESCC sisters and 7 other family members. The splice variant mutation results in exon 5 skipping with a frame shift leading to a premature stop codon in exon 6 and truncation. Novel mutation tracking ruled out single nucleotide polymorphism (SNP) in 100 chromosomes of healthy individuals. CONCLUSIONS:BRCA2 germline mutation in ESCC patients may play a role in genetic susceptibility to familial ESCC. Genetic analysis of BRCA2 in patients with familial
BACKGROUND Esophageal squamous cell carcinoma (ESCC) is a life-threatening digestive tract malignancy with no known curative treatment. This study aimed to investigate the antineoplastic effects of omipalisib and its underlying molecular mechanisms in ESCC using a high throughput screen. MATERIAL AND METHODS MTT assay and clone formation were used to determine cell viability and proliferation. Flow cytometry was conducted to detect cell cycle distribution and apoptosis. Global gene expression and mRNA expression levels were determined by RNA sequencing and real-time PCR, respectively. Protein expression was evaluated in the 4 ESCC cell lines by Western blot analysis. Finally, a xenograft nude mouse model was used to evaluate the effect of omipalisib on tumor growth in vivo. RESULTS In the pilot screening of a 1404-compound library, we demonstrated that omipalisib markedly inhibited cell proliferation in a panel of ESCC cell lines. Mechanistically, omipalisib induced G₀/G₁ cell cycle arrest ...
Several immune checkpoint inhibitors targeting programmed death ligand 1 (PD-L1)/programmed death 1 have successfully improved the prognosis of oesophageal squamous cell carcinoma (ESCC) with approval in certain countries. However, whether the expression of PD-L1 is associated with the degree of benefit is unclear yet and a unified standard of antibody and cut-off value of PD-L1 detection is also lacking. The current meta-analysis then aimed to explore the association between PD-L1 expression and clinicopathological features as well as prognosis in ESCC.. A systematic search on PubMed, Embase, Cochrane Library and Web of Science databases was performed up to 30 March 2021. The correlation between PD-L1 expression and clinicopathological features, as well as prognosis in ESCC, was estimated with the random-effects model.. A total of 5368 patients from 31 retrospective studies were enrolled. The overexpression of PD-L1 was significantly associated with lymph node metastasis (OR 1.342, 95% CI 0.995 ...
Background The aetiological role of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) has been widely researched for more than three decades, with conflicting findings. In the absence of a large, adequately powered single case-control study, a meta-analysis of all available case-control studies is the most rigorous way of identifying any potential association between HPV and OSCC. We present the first global meta-analysis of case-control studies investigating the role of HPV in OSCC. Methods Case-control studies investigating OSCC tissue for presence of HPV DNA were identified. 21 case-control studies analyzing a total of 1223 cases and 1415 controls, met our inclusion criteria. HPV detection rates were tabulated for each study and all studies were assessed for quality. The random effects method was used to pool the odds ratios (OR). Results From all OSCC specimens included in this meta-analysis, 35% (426/1223) were positive for HPV DNA. The pooled OR for an HPV-OSCC association
Esophageal cancer is one of the top reasons for cancer-related deaths worldwide, and esophageal squamous cell carcinoma (ESCC) accounts for up to 90% of all esophageal cancer cases. One of the major reasons for the high mortality rate is the lack of targeted therapies for ESCC, particularly for advanced stage disease. The tumor microenvironment (TME) is a complex system of multiple cell types (fibroblasts, immune cells, blood and lymphatic vessels, etc.) that supports tumor growth in various ways. We aimed to investigate some of the mechanisms of dynamic interaction between tumor cells and TME components and to identify approaches to targeting these interactions therapeutically. Desmoplasia, or deposition of connective tissue components (fibroblasts and extracellular matrix (ECM)), is a pronounced histological feature of ESCC. Previous research from the Rustgi lab and others has underscored the importance of cancer-associated fibroblasts (CAFs) and ECM components for ESCC progression. We have identified
MicroRNA Polymorphisms and Environmental Smoke Exposure as Risk Factors for Oesophageal Squamous Cell Carcinoma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - JOUR. T1 - Management of esophageal squamous cell carcinoma with definitive chemoradiotherapy in a patient with scleroderma. T2 - Case report and review of the literature. AU - Horowitz, David P.. AU - Halmos, Balazs. AU - Poneros, John. AU - Sonett, Joshua. AU - Remotti, Helen. AU - Burri, Ryan J.. PY - 2012/9/1. Y1 - 2012/9/1. UR - http://www.scopus.com/inward/record.url?scp=84887401191&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84887401191&partnerID=8YFLogxK. U2 - 10.1007/s12029-012-9393-2. DO - 10.1007/s12029-012-9393-2. M3 - Review article. C2 - 22585471. AN - SCOPUS:84887401191. VL - 43. SP - S156-S160. JO - Journal of Gastrointestinal Cancer. JF - Journal of Gastrointestinal Cancer. SN - 1941-6628. IS - SUPPL. 1. ER - ...
MicroRNA-21 (miR-21) was previously reported being dysregulated in many kinds of cancer including esophageal squamous cell carcinoma (ESCC). In the present study, we aimed to investigate the role of miR-21 in ESCC, especially in its effects on radiation-sensitivity of ESCC. Expression of miR-21 was detected in 63 pairs ESCC tumor and adjacent non-tumoral tissues using qRT-PCR, correlation between miR-21 and clinicopathological feature of ESCC was analyzed. The role of miR-21 in the proliferation, cell cycle and apoptosis of ESCC cells during irradiation were studied. MicroRNA-21 expression was significantly increased in ESCC tumor tissues. Expression of miR-21 was positively associated with advanced clinical stage. Under irradiation, overexpression of miR-21 increased cell proliferation and cells in S phase, and inhibited cell apoptosis of ESCC cells. In contrast, knockdown of miR-21 had an opposite effect. Downregulation of miR-21 inhibited the radiation-resistance of ESCC, whereas overexpression of
Esophagus cancer survival rate is now improving due to advanced technology. This does not only refer to the equipment, machine or drugs used to cure esophagus cancer. This also includes commercial media as great sources of finding treatments. There is already the Internet to get information about esophagus cancer and
We retrospectively examined esophageal cancer patients who received enteral nutrition (EN) to clarify the validity of early EN compared with delayed EN. A total of 103 patients who underwent transthoracic esophagectomy with three-field lymphadenectomy for esophageal cancer were entered. Patients were divided into two groups; Group E received EN within postoperative day 3, and Group L received EN after postoperative day 3. The clinical factors such as days for first fecal passage, the dose of postoperative albumin infusion, differences of serum albumin value between pre- and postoperation, duration of systematic inflammatory response syndrome (SIRS), incidence of postoperative infectious complication, and use of total parenteral nutrition (TPN) were compared between the groups. The statistical analyses were performed using Mann-Whitney U test and Chi square test. The statistical significance was defined as p < 0.05. Group E showed fewer days for the first fecal passage (p < 0.01), lesser dose of
The role of environmental factors is evident from the short time period over which the incidence of Barretts oesophagus6 and oesophageal adenocarcinoma7 has increased. Furthermore, the demonstration of a birth cohort effect, with higher incidence rates in younger cohorts,8 would support the idea that exposure to environmental factors in early life is an important determinant of risk. Identification of specific environmental exposures is difficult, but factors that increase gastro-oesophageal reflux, such as dietary components, increasing body mass index and eradication of Helicobacterpylori, may be relevant.9 Whether or not smoking and alcohol consumption are risk factors for Barretts oesophagus is controversial; however, an association was found in a recent population study.10 In order for an individual to develop Barretts oesophagus, and in some cases oesophageal adenocarcinoma, these environmental exposures probably need to interact with genetically determined characteristics that define ...
Approximately 38,000 new patients will be diagnosed with gastroesophageal cancer in 2008.1 Although this number may be trivial compared with more common cancers, the incidence of esophageal and gastroesophageal junction adenocarcinoma has been steadily climbing over the past 20 years (www.cancer.org; accessed June 10, 2008). Although obesity, gastroesophageal reflux, and Barretts metaplasia may contribute some or great extent to this alarming increase, some of the reasons for this increase remain elusive.2 The global health burden imposed by gastroesophageal cancer parallels that imposed by lung cancer, with approximately 1.4 million new cases and 1.1 million deaths per year.3 Furthermore, the mortality is likely to remain high because early detection of gastroesophageal cancer is not commonly practiced in most countries. Nevertheless, we have witnessed some definite progress in staging and therapy of patients with gastroesophageal cancer. For localized gastroesophageal cancer, progress has ...
Hiura, Y., Takiguchi, S., Yamamoto, K., Takahashi, T., Kurokawa, Y., Yamasaki, M., Nakajima, K., Miyata, H., Fujiwara, Y., Mori, M., Kangawa, K. and Doki, Y. (2012), Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients. Cancer, 118: 4785-4794. doi: 10.1002/cncr.27430 ...
Background: Obesity is associated with an increased risk of esophageal adenocarcinoma (EAC) and a decreased risk of esophageal squamous cell carcinoma (ESCC). However, little is known about the risk of EAC and ESCC related to other metabolic risk factors. We aimed to examine the risk of EAC and ESCC in relation to metabolic risk factors, separately and combined in a prospective cohort study. Methods: The Metabolic Syndrome and Cancer cohort includes prospective cohorts in Austria, Norway and Sweden, with blood pressure, lipids, glucose and BMI available from 578 700 individuals. Relative risk (RR) for EAC and ESCC was calculated using Coxs proportional hazards analysis for metabolic risk factors categorized into quintiles and transformed into z-scores. The standardized sum of all z-scores was used as a composite score for the metabolic syndrome (MetS). Results: In total, 324 histologically verified cases of esophageal cancer were identified (114 EAC, 184 ESCC and 26 with other histology). BMI ...
Background. Recent studies have shown that the aberrant expression of IFITM3 is implicated in the lymph node metastasis of many malignancies. Our research aimed to investigate the expression of IFITM3 in pathological N0 (pN0) esophageal squamous cell carcinoma (ESCC) and its relationship with lymph node metastatic recurrence.Methods. Immunohistochemistry (IHC) was used to examine the expression profile of IFITM3 in 104 pairs of samples. Each pair consisted of ESCC tissue and its adjacent normal mucosa (ANM). This aberrant expression was verified by reverse transcription-polymerase chain reaction (RT-PCR) with 20 tumor specimens with strong immunostaining and their mucosal tissues. In addition, 20 samples of low expression tissues and their ANMs were evaluated. Moreover, the correlations between the IFITM3 expression level and the clinicopathological variables, recurrence risk and overall survival (OS) of patients were analyzed.Results. Both IHC and RT-PCR demonstrated that the IFITM3 expression level
Statins comprise a class of prescription drugs used for reducing cholesterol. Evidence has also showed that statins could reduce cancer incidence. However, the anti-tumor mechanism of statins has not been fully defined. Here, we found that atorvastatin inhibited proliferation of esophageal squamous cell carcinoma (ESCC) cells. The underlying mechanisms were explored by mass spectrometry. The proteome data revealed that atorvastatin inhibited the cAMP and Rap1 signal pathways, except for Ras signal pathway. Interestingly, phosphoproteome profiles suggested that ERKT185/Y187, CDK1T14, and BRAC1S1189 phosphorylation–mediated Th17 cell differentiation, Gap junction and the Platinum drug resistance pathway were down-regulated after atorvastatin treatment. The phosphorylation levels of ERKT185/Y187, CDK1T14 and BRAC1S1189 were confirmed by western blotting in KYSE150 cells. More importantly, atorvastatin suppresses ESCC tumor growth in
https://doi.org/10.18632/oncotarget.15651 Pengxiang Chen, Lihui Han, Cong Wang, Yibin Jia, Qingxu Song, Jianbo Wang, Shanghui Guan, Bingxu Tan, Bowen Liu, Wenqiao Jia, Jianfeng Cui, Wei Zhou, Yufeng...
Dr. Bin Wang developed the investigational vaccine used in this clinical trial and designed the trial protocol.For patients with advanced esophageal squamous carcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma and colorectal adenocarcinoma tumor who have disease progression with first line chemotherapy. Single or multiple doses of personalized mRNA tumor vaccine encoding neoantigen will be given to observe the safety and efficacy the mRNA tumor vaccine.. Primary objectives:. Determine the safety, tolerability and cytokinetics of the personalized mRNA tumor vaccine in patients with advanced esophageal squamous carcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma and colorectal adenocarcinoma.. Secondary objectives:. Make a preliminary evaluation on the efficacy of personalized mRNA tumor vaccine in patients with advanced esophageal squamous carcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma and colorectal adenocarcinoma with the following parameters:. Time of tumor ...
Abstract: There is a region with a high risk for esophageal squamous cell carcinoma (ESCC) in the northeast of Iran. Previous studies suggest that hereditary factors play a role in the high incidence of cancer in the region. We selected 22 functional variants (and 130 related tagSNPs) from 15 genes that have been associated previously with the risk of ESCC. We genotyped a primary set of samples from 451 Turkmens (197 cases and 254 controls). Seven of 152 variants were associated with ESCC at the P = 0.05 level; these single nucleotide polymorphisms were then studied in a validation set of 549 cases and 1,119 controls, which included both Turkmens and non-Turkmens. The association observed for a functional variant in ADH1B was confirmed in the validation set, and that of a tagSNP in MGMT, the association was borderline significant in the validation set, after correcting for multiple testing. The other 5 variants that were associated in the primary set were not significantly associated in the ...
Esophageal cancer is cancer that occurs in the esophagus, the long, hollow tube that runs from your throat to your stomach. Your esophagus carries food you swallow to your stomach to be digested. Esophageal cancer begins in the cells that line the inside of the esophagus and can occur anywhere in the esophagus. In the United States, it occurs most often in the lower portion of the esophagus. The Esophageal Cancer Action Network can offer more information about esophageal cancer and ways to promote awareness. While this disease is rare, esophageal cancer is one of the deadliest forms of cancer. In the localized stage, meaning it is only growing in the esophagus, this cancer has only a 38 percent five-year survival rate. In the regional stage, the cancer has spread to nearby lymph nodes or tissues. This stage has only a 20 percent survival rate. The distant stage, when the cancer has spread to other organs, has a 3 percent survival rate. The cause of esophageal cancer is unknown. Esophageal cancer ...
Esophageal squamous cell carcinoma (ESCC) is a deadly disease, partly because it is often diagnosed late in disease stage. An accurate early diagnosis by endoscopy could detect advanced carcinoma as...
Measuring tumor cell proliferation with 18F-FLT PET during radiotherapy of esophageal squamous cell carcinoma: a pilot clinical study.
Backgrounds: Emerging evidences has demonstrated that dysregulation of long non-coding RNAs (lncRNAs) is critically involved in esophageal squamous cell carcinoma (ESCC) progression. However, the function of lncRNA PSMA3-AS1 in ESCC is unclear. Therefore, we aimed to explore the functions and potential mechanisms of PSMA3-AS1 in ESCC cells progression.Results: Here, we found that PSMA3-AS1 expression was significantly up-regulated in ESCC tissues. Forced PSMA3-AS1 expression was correlated with tumor size, distant metastasis, and poor prognosis in ESCC patients. Functionally, PSMA3-AS1-overexpression promoted ESCC cells proliferation, invasion, and migration in vitro. Mechanistically, PSMA3-AS1 up-regulated EZH2 expression by competitively binding to miR-101.Conclusion: PSMA3-AS1 is significantly up-regulated in ESCC tissues, and the PSMA3-AS1/miR-101/EZH2 axis plays a critical role in ESCC progression. Taken together, our results may provide promising targets for ESCC therapy.Methods: PSMA3-AS1 and miR
TY - JOUR. T1 - Fatal hemorrhage in irradiated esophageal cancer patients. AU - Nemoto, Kenji. AU - Takai, Yoshihiro. AU - Ogawa, Yoshihiro. AU - Kakuto, Yoshihisa. AU - Ariga, Hisanori. AU - Matsushita, Haruo. AU - Wada, Hitoshi. AU - Yamada, Shogo. PY - 1998. Y1 - 1998. N2 - Between 1980 and 1994, 423 patients with esophageal cancer were given curative radiation therapy. Of these patients, 31 died of massive hemorrhage and were used as the subjects of analysis in this study. The incidence of massive hemorrhage in all patients was 7% (31/423). In the 31 patients who died of massive hemorrhage, 27 had local tumors and two had no tumors at hemorrhage (two unknown cases). The mean time interval from the start of radiation to hemorrhage was 9.2 months. In 9 autopsy cases the origin of hemorrhage was a tear of the aorta in 5 cases, necrotic local tumor in 3 cases and esophageal ulcer in 1 case. The positive risk factors for this complication seemed to be excess total dose, infection, metallic stent, ...
Autoantibodies Response to MDM2 and p53 in the Immunodiagnosis of Esophageal Squamous Cell Carcinoma | Chai, Y.; Peng, B.; Dai, L.; Qian, W.; Zhang, Y.; Zhang, J.-Y. | download | BookSC. Download books for free. Find books
A pathological complete response (pCR) after neoadjuvant chemoradiotherapy (NACRT) ensures long-term survival in esophageal squamous cell carcinoma (ESCC) patients following esophagectomy, but pCR patients are a minority. The aim here was to identify prognostic factors in patients with non-pCR ESCC after NACRT. This is a retrospective study. Investigated were 5-year overall survival (OS), disease-specific survival (DSS), and relapse-free survival (RFS) among non-pCR ESCC patients divided into pT0N0, primary site pCR (pT0N+), lymph node pCR (pT+N0), and non-pCR in both the tumor and lymph node (pT+N+) subgroups after NACRT and esophagectomy. Focusing on the SUVmax reduction rate in the primary tumor in 88 patients who underwent FDG-PET before and after NACRT, we used univariate and multivariate Cox proportional hazard models to identify prognostic factors. Although there were no significant survival differences among non-pCR ESCC patients with pT0N+, pT+N0, or pT+N+, survival rate among pT+N+patients was
The progression of BM to BAc passes through well-established histological changes, in which dysplasia is considered the most advanced phenotypic change before invasive cancer sets in.1 2 36 However, not all dysplastic lesions progress to cancer, and a better understanding of the molecular biology of this disease may lead to improvements in the diagnosis, treatment and prognosis of patients with BE.37. PDCD4 has been characterised as a new tumour suppressor gene, which is downregulated in several human malignancies.19-24 Its overexpression inhibits neoplastic transformation in both cancer cell lines and in vivo models.10 38 39. Low PDCD4 protein levels (assessed by western blot and qRT-PCR analyses) have been observed in oesophageal squamous cell carcinoma cell lines.18 In a large series of oesophageal tumours, we recently found that PDCD4 protein was completely lost or significantly reduced in almost 60% of the tumour samples considered.25 As in the lung cancer setting,20 no significant ...
The outcome of patients with localized carcinoma of the esophagus remains dismal despite some advances in chemotherapy agents, an improved understanding of chemoradiobiology, and improvement in multidisciplinary care. The pathCR rates are approximately 27%.14 The therapeutic approach has been empiric for decades. Any substantial gains may not be anticipated by continued empiric approaches. Therefore, more attention to clinical biology may be needed and, more important, molecular biology and patient genetics. Deriving therapy based on the molecular biology of the tumor and patient genetics is a major challenge but a much-needed effort. However, at the current time, there is an opportunity to study the clinical biology of esophageal cancer.. ACA and SCC appear to have a distinct clinical profile. ACA occurs predominantly in white men and is often associated with increased body mass index and chronic gastroesophageal reflux disease, whereas SCC, although more common in men, is predominantly a ...
TY - JOUR. T1 - Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway. AU - Nguyen, Dao M.. AU - Chen, G. Aaron. AU - Reddy, Rishindra. AU - Tsai, Wilson. AU - Schrump, William D.. AU - Cole, George. AU - Schrump, David S.. AU - Jones, David A.. AU - Mentzer, Steven J.. AU - Harpole, David H.. PY - 2004/2. Y1 - 2004/2. N2 - Background: Constitutive activation of the phosphoinositide 3-kinase/protein kinase B survival signal transduction pathway influences the intrinsic chemoresistance of cancer cells. This study evaluates the effect of LY294002, a pharmacologic inhibitor of phosphoinositide 3-kinase, on the sensitivity of lung and esophageal cancer cells to paclitaxel (Taxol) in vitro. Materials and Methods: Cell viability and apoptosis of cancer cells treated with paclitaxel + LY294002 combinations were quantitated by methyl-thiazol-diphenyl-tetrazolium and ...
Numerous molecular alterations in ESCC tumors have been identified. Among them, TP53 alterations are the most common. One study of 56 ESCC cases from north central China found at least 1 genetic alteration in TP53 in 96% of the tumors studied, including mutations (77%), allelic loss within the gene (73%), and/or LOH at the TP53 microsatellite marker (80%); and three quarters of the cases had 2 or more such alterations (11). In a study conducted in northeastern Iran, 90% of the 119 ESCC cases evaluated had a TP53 mutation, including 11 with 2 or 3 mutations (12). The TP53 mutation pattern observed in this study was heterogeneous, in a manner suggestive of environmental exposures. Typical hotspots were only infrequently mutated, whereas 40% of altered bases were at mutagenesis sites known to be associated with polycyclic aromatic hydrocarbon exposure, and the mutation patterns differed by the reported temperature of the tea consumed. Another study of 60 ESCCs from north central China observed at ...
TY - JOUR. T1 - Does paclitaxel improve the chemoradiotherapy of locoregionally advanced esophageal cancer? A nonrandomized comparison with fluorouracil-based therapy. AU - Adelstein, David J.. AU - Rice, Thomas W.. AU - Rybicki, Lisa A.. AU - Larto, Marjorie A.. AU - Ciezki, Jay. AU - Saxton, Jerrold. AU - DeCamp, Malcolm. AU - Vargo, John J.. AU - Dumot, John A.. AU - Zuccaro, Gregory. PY - 2000/1/1. Y1 - 2000/1/1. N2 - Purpose: A phase II trial of accelerated fractionation radiation with concurrent cisplatin and paclitaxel chemotherapy was performed to investigate the role of the paclitaxel, when substituted for fluorouracil (5-FU), in the chemoradiotherapy of esophageal cancer. Patients and Methods: Patients with an esophageal ultrasound stage of T3 or N1 or M1 (nodal) esophageal cancer were treated with two courses of a cisplatin infusion (20 mg/m2/d for 4 days) and paclitaxel (175 mg/m2 over 24 hours) concurrent with a split course of accelerated fractionation radiation (1.5 Gy bid to a ...
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Oesophago-gastric cancer referrals should be made using the standard two week wait referral proforma from the Healthy London Partnership website
TY - JOUR. T1 - A case of esophageal adenocarcinoma metastasized to the scalp. AU - Park, Jin Mo. AU - Kim, Dae Suk. AU - Oh, Sang Ho. AU - Kwon, Yeon Sook. AU - Lee, Kwang Hoon. PY - 2009/12/1. Y1 - 2009/12/1. N2 - Cutaneous metastases from internal malignancies are, occurring in 0.5% to 9% of cases. Lung, breast, and colorectal cancers are common primary tumors that metastasize to the skin; cutaneous metastasis usually occurs on the chest wall and abdomen as asymptomatic nodular patterns. Esophageal cancer is not nearly as common as breast, lung, and colorectal cancers, and esophageal cancer rarely metastasizes to the skin. Cutaneous metastasis of esophageal cancer is rare and metastasis to the scalp is extremely rare. Only a few cases of cutaneous metastases of esophageal cancer have been reported in Korea. Most of the cases involved cutaneous metastases arising from esophageal squamous cell carcinoma; however, there have been several reports describing cutaneous metastases from esophageal ...
Background: A steep increase in the incidence of esophageal adenocarcinoma has been observed between 1973 and 2001, but recent trends have not been reported. Our aim was to examine recent trends in esophageal adenocarcinoma incidence.. Methods: We used the Surveillance Epidemiology and End Results database of the National Cancer Institute to identify all patients who were diagnosed with esophageal adenocarcinoma between 1973 and 2006. Incidence trends were analyzed for esophageal adenocarcinoma overall and by stage using joinpoint regression.. Results: Overall esophageal adenocarcinoma incidence increased from 3.6 per million in 1973 to 25.6 per million in 2006. Incidence trend analysis, however, suggests that the increase has slowed, from an 8.2% annual increase prior to 1996 to 1.3% increase in subsequent years (P = 0.03). Stage-specific trend analyses suggest that the change in overall esophageal adenocarcinoma incidence largely reflects a plateau in the incidence of early stage disease. Its ...
2322 Abstract: Nuclear retinoid receptors (RARs) play an important role in growth, differentiation and apoptosis of normal, premalignant and malignant epithelial cells. Alteration of RARs has been reported to promote tumorigenesis. Our previous studies have demonstrated that RAR-beta2 expression is selectively and progressively lost in a variety of human cancers. Induction of RAR-beta2 inhibited growth of esophageal cancer cells and induced them to undergo apoptosis. Both the tobacco carcinogen BPDE and tumor promoter bile acids, which are important risk factors in esophageal carcinogenesis, suppressed RAR-beta2 expression in a premalignant and different malignant esophageal cell lines. These observations suggest that RAR-beta2 is particularly important in suppressing esophageal carcinogenesis. However, little is known about the mechanism of action of RAR-beta2 and about RAR-beta2-target genes. After years of studying the nuclear retinoid receptors in cancer cell growth, differentiation, and ...
esophageal neoplasm (en) , esophageal disease (en) gastrointestinal system cancer (en) Espezialitatea. onkologia. ... NCI Prevention: Dietary Factors, based on Chainani-Wu N. Diet and oral, pharyngeal, and esophageal cancer. Nutr Cancer 2002;44: ... Kenneth J. Vega, M.D., M. Mazen JamaM.D.l (Sep de 2000). «Changing pattern of esophageal cancer incidence in New Mexico». ... Corley DA, Kerlikowske K, Verma R, Buffler P. Protective association of aspirin/NSAIDs and esophageal cancer: a systematic ...
"Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma". Int J Clin Exp ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term 'neoplasm' is a synonym of "tumor". 'Neoplasia' denotes the process of the formation of neoplasms/tumors, the process ... "II Neoplasms". World Health Organization. Retrieved 19 June 2014.. *^ a b Abrams, Gerald. "Neoplasia I". Retrieved 23 January ...
ISBN 0-7216-2921-0. Radiologic Pathology Archives: Esophageal Neoplasms: Radiologic-Pathologic Correlation Rachel B. Lewis, ... Accessed 2017-07-08 Radiologic Pathology Archives: Esophageal Neoplasms: Radiologic-Pathologic Correlation Rachel B. Lewis, ... Mesenchymal neoplasms of the gallbladder are rare and in particular leiomyomas of the gallbladder have been rarely reported, ... Fibromyoma of the breast is an extremely rare benign breast neoplasm. Most reports in literature mention a history of ...
... choroid neoplasms MeSH C04.588.364.978.400 - iris neoplasms MeSH C04.588.443.353 - esophageal neoplasms MeSH C04.588.443.392 - ... gallbladder neoplasms MeSH C04.588.274.476 - gastrointestinal neoplasms MeSH C04.588.274.476.205 - esophageal neoplasms MeSH ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... femoral neoplasms MeSH C04.588.149.721 - skull neoplasms MeSH C04.588.149.721.450 - jaw neoplasms MeSH C04.588.149.721.450.583 ...
... common bile duct neoplasms MeSH C06.301.120.401 - gallbladder neoplasms MeSH C06.301.371.205 - esophageal neoplasms MeSH ... esophageal neoplasms MeSH C06.405.117.468 - esophageal perforation MeSH C06.405.117.468.524 - mallory-weiss syndrome MeSH ... esophageal neoplasms MeSH C06.405.249.308 - gastrointestinal stromal tumors MeSH C06.405.249.411 - intestinal neoplasms MeSH ... common bile duct neoplasms MeSH C06.130.320.120 - bile duct neoplasms MeSH C06.130.320.120.280 - common bile duct neoplasms ...
See: "C16 - Malignant neoplasm of the stomach". ICD-10 Version: 2015. World Health Organization. Archived from the original on ... NCI esophageal cancer Cancer.Net: Esophageal Cancer Esophageal Cancer From Cancer Management: A Multidisciplinary Approach ... esophageal squamous-cell carcinoma) comprises 60-70% of all cases of esophageal cancer worldwide, while EAC (esophageal ... and T3 stages of esophageal cancer Stage T4 esophageal cancer Esophageal cancer with spread to lymph nodes Prevention includes ...
"Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma". Int J Clin Exp Pathol ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term "neoplasm" is a synonym of "tumor". "Neoplasia" denotes the process of the formation of neoplasms/tumors, the process ... p. Neoplasm. ISBN 978-0781733908. "II Neoplasms". International Statistical Classification of Diseases and Related Health ...
Digestive system neoplasms are tumors which affect the digestive system. Types include: esophageal cancer gastric cancer small ...
Esophageal atresia Esophageal disorder Esophageal duodenal atresia abnormalities of hands Esophageal neoplasm Esophageal ... protoporphyria Escher-Hirt syndrome Escherichia coli infection Esophageal atresia associated anomalies Esophageal atresia ...
Esophageal cancer[edit]. Squamous carcinoma of the esophagus is more prevalent in coeliac disease.[114][115] The increased ... also EATL is the most common neoplasm.[7] ...
... especially for large or ulcerative neoplasms. Recently, the ESD technique is applied to esophageal or colorectal neoplasms in ... The resected size and shape can be controlled, en bloc resection is possible even in a large neoplasm, and neoplasms with ... So this technique can be applied to the resection of complex neoplasms such as large neoplasms, ulcerative non-lifting ... For a reliable en bloc resection of GI neoplasms, a new method of ER called endoscopic submucosal dissection (ESD) has been ...
Toluidine blue stains nuclei of malignant cells blue, and is used in oral and esophageal squamous cell carcinoma. Crystal ... violet is absorbed into intestinal and neoplastic cells and is used to identify Barrett's esophagus and colonic neoplasms. ...
They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... For example, mass effects from lung cancer can block the bronchus resulting in cough or pneumonia; esophageal cancer can cause ... Frequent consumption of scalding hot tea may produce esophageal cancer.[64] Generally, it is believed that cancer arises, or a ...
... esophageal carcinoma, gastric carcinoma, glioblastoma, liver carcinoma, lymphoma, melanoma, small cell lung carcinoma, T-cell ... B-cell neoplasm, breast carcinoma, Burkitt's lymphoma, colorectal adenocarcinoma, carcinoma, cutaneous T cell lymphoma, ...
... malignant neoplasms at high risk of bleeding, recent brain injury or spinal injury, recent brain, spinal or ophthalmic surgery ... known or suspected esophageal varices, arteriovenous malformations, aneurysms or major intraspinal or intracerebral vascular ...
In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... esophageal cancer and lung cancer. Cellular DNA integrity is often compromised in cancer. Genome instability can refer to the ... Overexpression of H19 appears to be important in the development of esophageal and colorectal cancer cells Cells expressing H19 ... "Loss of H19 imprinting in esophageal cancer". Cancer Res. 56 (3): 480-482. PMID 8564957. Lottin S, Adriaenssens E, Dupressoir T ...
For esophageal cancer radiation treatment, brachytherapy is one option for effective treatment, involves definitive ... GammaTile is FDA-cleared to treat newly diagnosed, operable malignant intracranial neoplasms (ie, brain tumors) and operable ... Brachytherapy is commonly used as an effective treatment for cervical, prostate, breast, esophageal and skin cancer and can ... for esophageal cancer". International Journal of Radiation Oncology, Biology, Physics. 21 (5): 1133-1135. doi:10.1016/0360-3016 ...
Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene. The function of this gene is not known ... "DEC1 expression in 1p-aberrant oligodendroglial neoplasms". Histol. Histopathol. 20 (4): 1173-7. PMID 16136500. Yang L, Leung ... "Entrez Gene: DEC1 deleted in esophageal cancer 1". Qian Y, Zhang J, Yan B, Chen X (2008). "DEC1, a basic helix-loop-helix ... This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent ...
... esophageal cancer as well as head and neck cancer. Besides those, reduced CK1δ activity owing to the site N172D mutation of CK1 ... hematopoietic malignancies and lymphoid neoplasms. Also decreased CK1δ mRNA expression levels have been observed in some cancer ...
An "esophageal cancer belt", in which the incidence of esophageal squamous cell carcinoma (SCC) is more than a hundred times ... from patients who had never had a gastric malignant neoplasm), non-tumor tissue adjacent to a gastric cancer, and gastric ... By the time esophageal cancer is usually detected, though, it might have spread beyond the esophageal wall, and the survival ... Esophageal cancer is the sixth-most-common cancer in the world, and its incidence is increasing. Some three to five males are ...
Negative effects include increased risk of liver diseases, oropharyngeal cancer, esophageal cancer and pancreatitis. Conversely ... and malignant neoplasms. The psychiatric disorders which are associated with alcoholism include major depression, dysthymia, ...
Some telangiectasias are due to developmental abnormalities that can closely mimic the behaviour of benign vascular neoplasms. ... The syndrome recognises the significantly co-presenting symptoms of calcinosis, Raynaud's phenomenon, esophageal dysmotility, ...
These were cancers of the brain, lung, bowel, breast, and bladder, and other neoplasms. Not only are benzodiazepines associated ... It can cause swallowing incoordination, high-peaked esophageal peristalsis, bronchospasm, delayed cricopharyngeal relaxation, ... abnormal esophageal peristalsis and associated bronchospasm: probable cause of nitrazepam-related sudden death". Brain & ...
Abdominal neoplasms Aberrant subclavian artery Ablepharon macrostomia syndrome Abnormal systemic venous return Abruzzo-Erickson ... familial esophageal Achalasia microcephaly Achard syndrome Achard-Thiers syndrome Acheiropodia Achondrogenesis Achondrogenesis ... X-linked Adrenal incidentaloma Adrenal insufficiency Adrenal macropolyadenomatosis Adrenal medulla neoplasm Adrenocortical ... Abdominal cystic lymphangioma Abdominal defects Abdominal musculature absent microphthalmia joint laxity Abdominal neoplasm / ...
... secondary to radiation therapy infection inflammation ischemia neoplasm - in such cases, the stenosis is often said to be " ... Phimosis Non-communicating hydrocephalus due to aqueductal stenosis Stenosing tenosynovitis Atherosclerosis Esophageal ... "malignant" or "benign", although this attribute actually refers to the neoplasm itself. smoking ureteral urethral Stenoses of ...
It receives the 9th, 10th, and 11th posterior intercostal veins and the subcostal vein of the left side, and some esophageal ... hemiazygos system displayed by chest or abdominal X-ray films can be misdiagnosed as a mediastinal or retroperitoneal neoplasm ...
... mRNA expression is reduced in colorectal neoplasms due to methylation of the promoter region of MBD4. A majority of ... MBD4 mutations also occur in tumor samples of melanoma, ovarian, lung, esophageal and prostate cancers at frequencies between ... compared to histologically normal tissue from individuals who never had a colonic neoplasm. This indicates that an epigenetic ...
... and oesophageal cancer. Med Mycol. 2008 Feb;46(1):85-91. doi: 10.1080/13693780701616023. PMID ... neoplasms and others. In most patients, chronic mucocutaneous candidiasis is correlated to abnormalities in cell mediated ... Patients with autosomal-dominant mucocutaneous candidiasis may be at risk for epidermoid esophageal cancer due to the ...
"MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma". Biochemical and Biophysical Research ... MicroRNA expression pattern in intraductal papillary mucinous neoplasm]". The Korean Journal of Gastroenterology = Taehan ... "MicroRNA analysis of microdissected normal squamous esophageal epithelium and tumor cells". American Journal of Cancer Research ...
Esophageal cancer. *Ewing's sarcoma. *Eye neoplasm. G. *Gallbladder cancer. *Gastrointestinal cancer. H. *Head and neck cancer ...
Esophageal lichen planus, affecting the esophageal mucosa. This can present with difficulty or pain when swallowing due to ... Salivary gland neoplasms *Benign: Basal cell adenoma. *Canalicular adenoma. *Ductal papilloma. *Monomorphic adenoma ... Chandan VS, Murray JA, Abraham SC (June 2008). "Esophageal lichen planus". Archives of Pathology & Laboratory Medicine. 132 (6 ... oesophageal inflammation, or as the development of an esophageal stricture. It has also been hypothesized that it is a ...
Keratosis palmoplantaris esophageal colon cancer. *Keratosis palmoplantaris papulosa. *Keratosis palmoplantaris with corneal ... Lymph node neoplasm. *Lymphadenopathy, angioimmunoblastic with dysproteinemia. *Lymphangiectasies lymphoedema type Hennekam ...
en:Neoplasm (40) → 신생물 *en:Nephrotic syndrome (38) → 신증후군 *en:Nervous system disease (4) ... en:Esophageal cancer (44) → 식도암 *en:Estrogen (medication) (2). *en:Evidence-based medicine (31) ...
As most early-stage cancers are asymptomatic, neoplasm of the gallbladder is found in late stages and has a poor prognosis. ... Esophageal motility disorder *Nutcracker esophagus. *Achalasia. *Esophagogastric junction outflow obstruction. *Diffuse ... Gallbladder cancer (Malignant neoplasm of the gallbladder) is rare, and most of the time is adenocarcinoma. ...
Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... "Automatic treatment planning facilitates fast generation of high-quality treatment plans for esophageal cancer". Acta ...
Myeloproliferative neoplasms including essential thrombocytosis and polycythemia vera[8]. *Chemotherapy[7][19] ...
Esophageal motility disorder *Nutcracker esophagus. *Achalasia. *Diffuse esophageal spasm. *Gastroesophageal reflux disease ( ... Neoplasms and cancer. *Inflammatory bowel disease. *Gluten sensitivity. *Other. *Symptoms and signs *eponymous ...
ಹೆಚ್ಚಿನ ದೃಷ್ಟಾಂತಗಳಲ್ಲಿ, ಹೆಪ್ಪುಕಾರಕ ವಿರೋಧಿ ಚಿಕಿತ್ಸೆಯು ಚಿಕಿತ್ಸೆಯ ಪ್ರಧಾನ ಆಧಾರವಾಗಿರುತ್ತದೆ. ಹೆಪಾರಿನ್, ಕಡಿಮೆ ಅಣುಗಳಿಗೆ ಸಂಬಂಧಿಸಿದ ತೂಕದ ಹೆಪಾರಿನ್‌ಗಳು (ಉದಾಹರಣೆಗೆ ಎನಾಕ್ಸೋಪಾರಿನ್ ಮತ್ತು ಡಾಲ್ಟೆಪರಿನ್), ಅಥವಾ ಫಂಡಾಪ್ಯಾರಿನಕ್ಸ್ ಇದು ಮೊದಲ ಹಂತದಲ್ಲಿ ಲೇಪಿಸಲ್ಪಡುತ್ತದೆ, ಹಾಗೆಯೇ ವಾರ್‌ಫಾರಿನ್, ಆಸಿನೋಕ್ಯುಮರಲ್, ಅಥವಾ ಫೆನ್‌ಪ್ರೊಕೌಮನ್ ಚಿಕಿತ್ಸೆಯು ಪ್ರಾರಂಭಗೊಳಿಸಲ್ಪಡುತ್ತದೆ (ಇದು ಹಲವಾರು ದಿನಗಳನ್ನು ...
Multiple myeloma/plasma cell neoplasm. *Myelodysplastic syndromes. *Mucosa-associated lymphoid tissue lymphoma ... Esophageal cancer. *Head and neck cancer. *Nasopharyngeal carcinoma. *Oral cancer. *Oropharyngeal cancer ...
Neoplasms III D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism ... I85) Oesophageal varices. *(I86) Varicose veins of other sites *(I86.0) Sublingual varices ...
Some polyps are tumors (neoplasms) and others are nonneoplastic (for example, hyperplastic or dysplastic). The neoplastic ones ... Esophageal motility disorder *Nutcracker esophagus. *Achalasia. *Diffuse esophageal spasm. *Gastroesophageal reflux disease ( ...
Esophageal motility disorder *Nutcracker esophagus. *Achalasia. *Diffuse esophageal spasm. *Gastroesophageal reflux disease ( ... Neoplasms, benign or malignant. *Intussusception. *Volvulus. *Superior mesenteric artery syndrome, a compression of the ...
... which may be benign neoplasms) or else a malignant neoplasm (cancer). These neoplasms are also indicated, in the diagram below ... esophageal adenocarcinoma and esophageal squamous-cell carcinoma, gastric cancer, bile duct cancer, pancreatic cancer, small ... The Hallmarks of Cancer as evolutionary adaptations in a neoplasm[edit]. In their landmark paper, The Hallmarks of Cancer,[3] ... Cells in neoplasms compete for resources, such as oxygen and glucose, as well as space. Thus, a cell that acquires a mutation ...
Thus, a clone with a mutation in a tumor suppressor gene or oncogene will expand only in a neoplasm if that mutation gives the ... "Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma". International ... Some of the small polyps in the field defect shown in the photo of the opened colon segment may be relatively benign neoplasms ... These neoplasms are also indicated (in the diagram below the photo) by 4 small tan circles (polyps) and a larger red area ( ...
2009). "Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal ... "Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms". N Engl J Med 369 (25): 2379-90. PMID 24325356. doi:10.1056/ ... "Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2". N Engl J Med 369 (25): 2391-405. PMC 3966280 ...
Benefits of endoscopic submucosal dissection according to size and location of gastric neoplasm, compared with conventional ... combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal ... plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal ...
Esophageal cancer (T), Esophageal food bolus obstruction (T), Familial adenomatous polyposis, Febrile neutropenia, Friedreich's ... Myeloproliferative neoplasm, Non-alcoholic fatty liver disease, Pericarditis, Paraneoplastic syndrome, Paroxysmal nocturnal ...
myeloprolirative neoplasms including essential thrombocytosis and. *Polycythemia vera[6]. *Chemotherapy[5][14] ...
Esophageal atresia: types A, B, C, and D. *Tracheoesophageal fistula: types B, C, D and E ... Neoplasms and cancer. *Inflammatory bowel disease. *Gluten sensitivity. *Other. *Symptoms and signs *eponymous ...
癌症(C00-D48, 140-239(英語:List of ICD-9 codes 140-239: neoplasms)). *腫瘤 ... Esophageal(英語:Esophageal disease). *Stomach(英語:Stomach disease). *Enteropathy(英語:Enteropathy) ...
... and left-sided colorectal neoplasms after colonoscopy: population-based study". J Natl Cancer Inst. 102 (2): 89-95. doi:10.1093 ... Esophageal pH monitoring. *Esophageal motility study. *Functional Lumen Imaging Probe. Stomach. *Sengstaken-Blakemore tube) ...
Neoplasms. Esophageal Neoplasms. Gastrointestinal Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Head and Neck ... Esophageal Neoplasms Procedure: Irreversible electroporation (IRE) Device: NanoKnife Phase 1 Phase 2 ... Irreversible Electroporation(IRE) For Unresectable Esophageal Neoplasms (IRE). The safety and scientific validity of this study ... By enrolling patients with unresectable Esophageal Neoplasms adapted to enrolled criteria, this study will document for the ...
Helicobacter pylori infection is associated with a decreased risk of developing oesophageal neoplasms.. Henrik Simán J1, ... Current smokers and ex-smokers have instead a definite increased risk of oesophageal neoplasms. ... High alcohol consumption was no longer significantly associated with oesophageal neoplasms after tobacco smoking was included ... Forty-four cases of oesophageal cancer and 149 matched controls were selected. The mean interval between screening and cancer ...
Conditions: GORD; Oesophageal Cancer; Oesophageal Reflux; Gastric Cancer; Gastro Esophageal Reflux; Oesophageal Carcinoma; ... Esophageal reconstruction using a pedicled jejunum following esophagectomy for metastatic esophageal stricture from breast ... Tu2004 ARTIFICIAL INTELLIGENCE NETWORK TO AID THE DIAGNOSIS OF EARLY ESOPHAGEAL SQUAMOUS CELL CARCINOMA AND ESOPHAGEAL ... Salvage endoscopic submucosal dissection for incompletely resected esophageal or gastric neoplasms (case series). *. ...
We examined DPC4 mutation in 30 examples of three other types of gastrointestinal malignancy: 10 esophageal cancers, 10 gastric ... Infrequent DPC4 Gene Mutation in Esophageal Cancer, Gastric Cancer and Ulcerative Colitis-Associated Neoplasms Oncogene. 1996 ... We examined DPC4 mutation in 30 examples of three other types of gastrointestinal malignancy: 10 esophageal cancers, 10 gastric ...
Trastuzumab Active Not Recruiting Phase 2 Trials for Neoplasms, Esophageal / Stomach Neoplasms Treatment. Back to Trastuzumab ... Combination Chemotherapy in Treating Patients With Advanced Stomach, Gastroesophageal, or Esophageal Cancer. *Oxaliplatin ( ...
The aim of this study was to evaluate the effect of ESD on superficial esophageal neoplasms and identify risk factors ... This study suggests that ESD has a strong therapeutic effect on superficial esophageal neoplasms; however, a greater extent of ... The complete resection rate of superficial esophageal neoplasms by ESD was 90.9%. After ESD, 22 subjects (18.3%) had ... This study included 165 lesions in 120 patients with superficial esophageal neoplasms, including cancer and neoplasia, who ...
... of the revised Vienna Classification for predicting postendoscopic resection outcomes for gastric and oesophageal neoplasms: a ... of the revised Vienna Classification for predicting postendoscopic resection outcomes for gastric and oesophageal neoplasms: a ... of the revised Vienna Classification for predicting postendoscopic resection outcomes for gastric and oesophageal neoplasms: a ...
... of the revised Vienna Classification for predicting postendoscopic resection outcomes for gastric and oesophageal neoplasms: a ... of the revised Vienna Classification for predicting postendoscopic resection outcomes for gastric and oesophageal neoplasms: a ... clinical management plan of gastro-oesophageal dysplasia and early neoplasia in a UK tertiary-centre population. ...
... * How to optimize the treatment strategy for patients with EGFR-mutant stage ... A young man with progressive esophageal neoplasms. Posted On 2019-01-11 19:12:43. ... Esophageal sarcomatoid carcinoma (ESC) is a rare malignancy, accounting for about 2% of esophageal malignancies. It is also ... Its clinical and radiological manifestations are similar to other esophageal tumors. Barium esophagogram usually reveals the ...
Esophageal Cancer. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a ... "Esophageal Neoplasms"Drugs, active principles and "Esophageal Neoplasms"Medicinal plantsQuestions and answers from other users ... Esophageal Neoplasms (Cancer of Esophagus; Esophageal Cancer). Tumors or cancer of the esophagus. ...
title = "Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update",. abstract = "Esophageal cancer (EC) is ... Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update. In Mansur L, Riemer B, McClintock D, editors, Clinics ... Zulfiqar, M., Bluth, M. H., & Bhalla, A. (2018). Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update. In L. ... Molecular Diagnostics in Esophageal and Gastric Neoplasms : 2018 Update. / Zulfiqar, Muhammad; Bluth, Martin H.; Bhalla, ...
Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms. / Ono, Satoshi; ... Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms. In: Gastrointestinal ... Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms. Gastrointestinal ... Background: The long-term outcomes of endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell neoplasms ...
Pathology esophageal carcinoma (90%) esophageal squamous cell carcinoma (SCC) esophageal spindle cell carcinoma ... ... Malignant esophageal neoplasms are much more common than benign esophageal neoplasms, especially if the patient is symptomatic ... malignant esophageal neoplasms* esophageal carcinoma (staging) *esophageal adenocarcinoma. * esophageal squamous cell carcinoma ... Malignant esophageal neoplasms are much more common than benign esophageal neoplasms, especially if the patient is symptomatic ...
Tag Archives: Keywords: esophageal neoplasm Blog Background: However the prevalence of esophageal cancers increases in older ... Keywords: esophageal neoplasm, older sufferers, radiotherapy, chemoradiotherapy, esophagectomy Launch Esophageal cancers (OC) ... esophageal neoplasmolder sufferersradiotherapySNX-2112squamous cell carcinoma SCC) occurrence rates continue steadily to lower ... Background: However the prevalence of esophageal cancers increases in older sufferers, its clinical history and final result ...
Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the ... Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the ... Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the ... Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the ...
Early esophageal cancer does not have symptoms. Factors that increase risk include heavy drinking and smoking. Learn how you ... ClinicalTrials.gov: Esophageal Neoplasms (National Institutes of Health) Journal Articles References and abstracts from MEDLINE ... Esophageal Cancer (National Cancer Institute) Also in Spanish * General Information about Esophageal Cancer (National Cancer ... Stages of Esophageal Cancer (National Cancer Institute) Also in Spanish * Understanding Esophageal Dilation (American Society ...
Esophageal Neoplasms. Gastrointestinal Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Neoplasms. Head and Neck ... Combination of Cryosurgery and NK Immunotherapy for Advanced Esophageal Cancer. The safety and scientific validity of this ... Metastatic Esophageal Cancer Device: Cryosurgery Biological: NK immunotherapy Phase 1 Phase 2 ... The aim of this study is the safety and efficacy of cryosurgery plus NK immunotherapy to advanced esophageal cancer. ...
There were 15 potentially clinically relevant predictive factors for gastric cancer and 10 for esophageal cancer. Conclusion: ... for esophageal cancer, 33 RCTs were identified (n = 8618 patients). In total, we identified 23 potentially clinically relevant ... and ASCO/ESMO conferences were searched up to March 2019 for RCTs on the curative treatment of esophageal or gastric cancer ... prognostic factors for gastric cancer and 16 for esophageal cancer. ...
Esophageal Neoplasms. Gastrointestinal Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Neoplasms. Head and Neck ... PD-1 Knockout Engineered T Cells for Advanced Esophageal Cancer. The safety and scientific validity of this study is the ... 16 advanced esophageal cancer patients are planned to receive two cycles of PD-1 knockout engineered T cells infusion. ... This study will evaluate the safety of PD-1 knockout engineered T cells in treating advanced esophageal cancer. Blood or tissue ...
Download And Read Superficial Esophageal Neoplasm Pathology Diagnosis And Therapy The River Pirates Longarm And The Branded ... Superficial esophageal neoplasm pathology diagnosis and therapy book . Download and read superficial esophageal neoplasm ... Download and read superficial esophageal neoplasm pathology diagnosis and therapy superficial esophageal neoplasm pathology ... esophageal neoplasm pathology diagnosis and therapy superficial esophageal carcinomas associated with superficial esophageal ...
Histological typing of gastric and oesophageal tumours / H. Watanabe, J. R. Jass and L. H. Sobin, in collaboration with ...
Adenocarcinoma was excluded in this study to focus on squamous neoplasms that account for most of the esophageal neoplasms in ... Favorable clinical outcomes were observed in ESD for superficial esophageal squamous neoplasms. Esophageal ESD could be a good ... We retrospectively reviewed 36 esophageal ESDs for superficial esophageal squamous neoplasms performed in 32 patients between ... this study shows favorable clinical outcomes in ESD for superficial esophageal squamous neoplasms, and reveals that esophageal ...
... population-based analysis of gastric cardia and distal esophageal adenocarcinomas, we found that patients with gastroesophageal ... Objective: Distal esophageal tumors and gastric cardia tumors, although only physically separated by centimeters, have ... Conclusion: Through a large, population-based analysis of gastric cardia and distal esophageal adenocarcinomas, we found that ... Survival of patients with distal esophageal and gastric cardia tumors: a population-based analysis of gastroesophageal junction ...
title = "Molecular diagnostics in esophageal and gastric neoplasms",. abstract = "Esophageal carcinoma is the most rapidly ... Molecular diagnostics in esophageal and gastric neoplasms. Muhammad Zulfiqar, Amarpreet Bhalla, Michael Weindel, Vinod B. ... Zulfiqar, M., Bhalla, A., Weindel, M., & Shidham, V. B. (2013). Molecular diagnostics in esophageal and gastric neoplasms. ... Molecular diagnostics in esophageal and gastric neoplasms. / Zulfiqar, Muhammad; Bhalla, Amarpreet; Weindel, Michael; Shidham, ...
Conclusions: Favorable clinical outcomes were observed in ESD for superficial esophageal squamous neoplasms. Esophageal ESD ... Conclusions: Favorable clinical outcomes were observed in ESD for superficial esophageal squamous neoplasms. Esophageal ESD ... Conclusions: Favorable clinical outcomes were observed in ESD for superficial esophageal squamous neoplasms. Esophageal ESD ... Conclusions: Favorable clinical outcomes were observed in ESD for superficial esophageal squamous neoplasms. Esophageal ESD ...
Esophageal neoplasms. Chest CT is currently the initial cross-sectional imaging modality of choice for the evaluation of ... Esophageal tumors include esophageal carcinoma, esophageal metastases, and less commonly esophageal leiomyoma. Typically, ... esophageal neoplasms.28,29 Upper endoscopy remains the standard means of esophageal lesion sampling and diagnosis. Mediastinal ... as thymic neoplasm. On CT, thymic hyperplasia can sometimes be difficult to differentiate from thymic neoplasm. Because the ...
The data of 3,714 patients with thoracic esophageal carcinoma from Apr, 1979 to Dec. 1994 were analysed in purpose to estimate ... Esophageal neoplasm Esophagectomy This is a preview of subscription content, log in to check access. ... Clinical evaluation of cervical esophageal reconstruction after resection of thoracic esophageal carcinoma. ... Lymph node metastasis in thoracic esophageal carcinoma. J Surg Oncol 1991; 48: 106.PubMedCrossRefGoogle Scholar ...
The purpose of this study is to provide access to paclitaxel therapy to subjects with advanced or recurrent esophageal canc... ... Esophageal Neoplasms. Tumors or cancer of the ESOPHAGUS.. Diverticulosis, Esophageal. A pathological condition characterized by ... Esophageal cancer is a common gastrointestinal cancer. About 300,000 people die from esophageal cancer every year in the world ... Esophageal Mucosa. Circular innermost layer of the ESOPHAGUS wall that mediates esophageal PERISTALSIS which pushes ingested ...
Keywords : Esophageal neoplasms; Squamous cell carcinoma; Caustics; adverse effects; Iodides; therapeutic use. ... LUGOLS IODINE CHROMOENDOSCOPY VERSUS NARROW BAND IMAGE ENHANCED ENDOSCOPY FOR THE DETECTION OF ESOPHAGEAL CANCER IN PATIENTS ... or if respiratory symptoms develop in an otherwise stable patient of esophageal stenosis. Narrow Band Imaging detects ... s solution chromendoscopy for detection of early esophageal cancer in patients with caustic/corrosive agent stenosis. ...
Esophageal Neoplasms. Tumors or cancer of the ESOPHAGUS.. Diverticulosis, Esophageal. A pathological condition characterized by ... Esophageal cancer is a common gastrointestinal cancer. About 300,000 people die from esophageal cancer every year in the world ... Esophageal Mucosa. Circular innermost layer of the ESOPHAGUS wall that mediates esophageal PERISTALSIS which pushes ingested ... Surgical incision of the lower esophageal sphincter near the CARDIA often used to treat ESOPHAGEAL ACHALASIA. ...
  • You're at greater risk for getting esophageal cancer if you smoke, drink heavily, or have acid reflux . (medlineplus.gov)
  • Forty-four cases of oesophageal cancer and 149 matched controls were selected. (nih.gov)
  • Esophageal reconstruction using a pedicled jejunum following esophagectomy for metastatic esophageal stricture from breast cancer in a patient with previous pancreatoduodenectomy. (medworm.com)
  • Conclusion Dyspepsia as a parameter to investigate gastric or oesophageal cancer contributes significantly to the growth in number of 2-week-wait referrals at a time when endoscopy units battle to meet demand. (medworm.com)
  • Our data show patients with uncomplicated dyspepsia rarely have gastric or oesophageal cancer and should not undergo endoscopies under the urgent 2-week-wait pathway. (medworm.com)
  • This study included 165 lesions in 120 patients with superficial esophageal neoplasms, including cancer and neoplasia, who underwent ESD from 2009 to 2013. (ovid.com)
  • Esophageal cancer (EC) is rapidly increasing in incidence in the United States. (elsevier.com)
  • Early esophageal cancer usually does not cause symptoms. (medlineplus.gov)
  • Your doctor uses imaging tests and a biopsy to diagnose esophageal cancer. (medlineplus.gov)
  • What's New in Esophageal Cancer Research and Treatment? (medlineplus.gov)
  • The aim of this study is the safety and efficacy of cryosurgery plus NK immunotherapy to advanced esophageal cancer. (clinicaltrials.gov)
  • By enrolling patients with pancreatic cancer adapted to enrolled criteria, this study will document for the first time the safety and the short and long term efficacy of the combined therapy using cryosurgery and nature killer (NK) cells for advanced esophageal cancer. (clinicaltrials.gov)
  • Background: An overview of promising prognostic variables and predictive subgroups concerning the curative treatment of esophageal and gastric cancer from randomized controlled trials (RCTs) is lacking. (mdpi.com)
  • Methods: PubMed, EMBASE, CENTRAL, and ASCO/ESMO conferences were searched up to March 2019 for RCTs on the curative treatment of esophageal or gastric cancer with data on prognostic and/or predictive factors for overall survival. (mdpi.com)
  • Results: For gastric cancer, 39 RCTs were identified ( n = 13,530 patients) and, for esophageal cancer, 33 RCTs were identified ( n = 8618 patients). (mdpi.com)
  • In total, we identified 23 potentially clinically relevant prognostic factors for gastric cancer and 16 for esophageal cancer. (mdpi.com)
  • There were 15 potentially clinically relevant predictive factors for gastric cancer and 10 for esophageal cancer. (mdpi.com)
  • This study will evaluate the safety of PD-1 knockout engineered T cells in treating advanced esophageal cancer. (clinicaltrials.gov)
  • 16 advanced esophageal cancer patients are planned to receive two cycles of PD-1 knockout engineered T cells infusion. (clinicaltrials.gov)
  • Keywords: esophageal neoplasm, older sufferers, radiotherapy, chemoradiotherapy, esophagectomy Launch Esophageal cancers (OC) may be the 8th most common cancers world-wide, with 481,000 brand-new situations (3.8% of the full total) approximated in 2008, as well as the sixth most common reason behind loss of life from cancer with 406,000 fatalities (5.4% of the full total) (1). (barasertib.info)
  • Methods: An ESD with methods similar to those used for resections of early gastric cancer was performed on 58 consecutive esophageal SCNs with preoperative diagnoses of intraepithelial neoplasm or intramucosal invasive carcinoma occurring in 43 enrolled patients. (elsevier.com)
  • Thus, ESD is widely applied for the treatment of early gastric cancer and colorectal neoplasms, and the outcomes are reported to be good. (e-ce.org)
  • Considering that the morbidity and mortality of surgical treatment are relatively high, most patients are older in age, and the quality of life is poor after surgery, endoscopic treatment for early esophageal cancer might have considerable benefits for patients who are not expected to have lymph node metastasis [ 10 ]. (e-ce.org)
  • As high-definition endoscopy with narrow-band imaging (NBI) was developed recently, the diagnosis of early esophageal cancer or esophageal premalignant lesions has increased. (e-ce.org)
  • CCRT for Esophageal Cancer. (bioportfolio.com)
  • The purpose of this clinical research study is to learn if BMS-181339 can shrink or slow the growth of the cancer in patients with advanced or recurrent esophageal cancer. (bioportfolio.com)
  • Paclitaxel is known to be active as a single and combination agent in esophageal cancer, and has also been demonstrated to have anti-angiogenic properties in weekly dosing regimens. (bioportfolio.com)
  • Lapatinib in combination with paclitaxel plays synergistic antitumor effects on esophageal squamous cancer. (bioportfolio.com)
  • Paclitaxel-based chemoradiotherapy was proven to be efficacious in treating patients with advanced esophageal cancer. (bioportfolio.com)
  • Enhancement of radiotherapeutic efficacy for esophageal cancer by paclitaxel-loaded red blood cell membrane nanoparticles modified by the recombinant protein anti-EGFR-iRGD. (bioportfolio.com)
  • Paclitaxel is widely used as a radiosensitizer for various tumors, including esophageal cancer, but its therapeutic effect remains to be improved. (bioportfolio.com)
  • Apoptosis and autophagy induced by DVDMs-PDT on human esophageal cancer Eca-109 cells. (bioportfolio.com)
  • Esophageal cancer is a common gastrointestinal cancer. (bioportfolio.com)
  • About 300,000 people die from esophageal cancer every year in the world. (bioportfolio.com)
  • The diagnostic outcomes of esophageal cancer by artificial intelligence using convolutional neural networks. (bioportfolio.com)
  • The prognosis of esophageal cancer is relatively poor. (bioportfolio.com)
  • The diagnosis of corrosion cancer should be suspected in patients with corrosive ingestion if after a latent period of negligible symptoms there is development of dysphagia, or poor response to dilatation, or if respiratory symptoms develop in an otherwise stable patient of esophageal stenosis. (scielo.br)
  • To determinate the clinical applicability of Narrow Band Imaging versus Lugol´s solution chromendoscopy for detection of early esophageal cancer in patients with caustic/corrosive agent stenosis. (scielo.br)
  • phase II trial is studying erlotinib to see how well it works in treating patients with advanced esophageal cancer or stomach cancer. (bioportfolio.com)
  • Erlotinib may keep esophageal cancer from forming in patients with Barrett esophagus by blocking some of. (bioportfolio.com)
  • The purpose of this study is to test the safety and effectiveness of erlotinib and FOLFOX in patients with esophageal or gastro-esophageal cancer that cannot be removed by surgery. (bioportfolio.com)
  • MicroRNA-873 acts as a tumor suppressor in esophageal cancer by inhibiting differentiated embryonic chondrocyte expressed gene 2. (bioportfolio.com)
  • Esophageal cancer is one of the most common digestive malignant diseases worldwide and emerging evidences revealed that microRNAs (miRNAs) were implicated in the development and progression of esophag. (bioportfolio.com)
  • Recurrence in oesophageal cancer continues to remain high after curative surgery. (isciii.es)
  • A retrospective and prospective follow-up study in patients with an anatomical-pathological diagnosis of oesophageal cancer who underwent curative surgery (n = 57) in the health district of A Coruña (Spain) during the period 2003-2008. (isciii.es)
  • The aim of this study was to demonstrate the characteristics and progress of patients with oesophageal cancer who have undergone curative surgery, as well as to study the risk factors for developing a recurrence. (isciii.es)
  • Videofluoroscopic evaluation in oropharyngeal swallowing after radical esophagectomy with lymphadenectomy for esophageal cancer. (biomedsearch.com)
  • BACKGROUND: After esophagectomy a swallowing abnormality is the predominant symptom for esophageal cancer. (biomedsearch.com)
  • BD stents offer an exciting new strategy for therapy-resistant benign strictures as well as a supportive measure for oesophageal cancer undergoing non-surgical treatment. (springer.com)
  • Lecleire S, Di Fiore F, Ben-Soussan E et al (2006) Prior chemoradiotherapy is associated with a higher life-threatening complication rate after palliative insertion of metal stents in patients with oesophageal cancer. (springer.com)
  • Patients undergoing oesophageal or cardia resection for cancer are monitored by mediastinal microdialysis during the postoperative period. (knowcancer.com)
  • Improving Outcomes in Radiotherapy Using New Strategies of Treatment Delivery With Focus on Oesophageal Cancer. (knowcancer.com)
  • Data from all 148 cases of oesophageal cancer in Bahrain during 1952-99 were analysed according to patient sex and age and site and histological pattern of tumour, and compared with other Gulf countries. (who.int)
  • In Bahrain, oesophageal cancer accounted for 2.6% of malignant neoplasms. (who.int)
  • If this is true, then expansion of a genetically unstable clone in a premalignant neoplasm will associate with risk of progression to cancer. (aacrjournals.org)
  • A 62-year-old man with a flat early esophageal cancer was referred for endoscopic treatment. (bvsalud.org)
  • Diagnosis of esophageal cancer or precursor lesions by endoscopic imaging depends on endoscopist expertise and is inevitably subject to interobserver variability. (cdc.gov)
  • The optimal dose of neoadjuvant radiation for locally advanced, resectable esophageal cancer remains controversial in the absence of randomized clinical trials, with conventional practice favoring the use of 50.4 vs. 41.4 Gy. (springer.com)
  • Retrospective analysis of adults with non-metastatic esophageal cancer in the National Cancer Database (2004-2015) treated with neoadjuvant chemoradiotherapy. (springer.com)
  • Compared to 50.4 Gy, 41.4 Gy is associated with reduced perioperative mortality and superior overall survival with similar downstaging in locally advanced esophageal cancer. (springer.com)
  • Note: Separate PDQ summaries on Esophageal Cancer Prevention , Esophageal Cancer Treatment (Adult) , and Levels of Evidence for Cancer Screening and Prevention Studies are also available. (cancer.gov)
  • Based on fair evidence, screening would result in no (or minimal) decrease in mortality from esophageal cancer in the U.S. population. (cancer.gov)
  • In 2020, it is estimated that 18,440 Americans will be diagnosed with esophageal cancer, and 16,170 will die of this malignancy. (cancer.gov)
  • The incidence of esophageal adenocarcinomas has risen considerably for the past two decades, such that it is now more prevalent than squamous cell cancer in the United States and Western Europe, with most tumors located in the distal esophagus. (cancer.gov)
  • To determine the safety and therapeutic effects of nimotuzumab (h-R3) combined with radiotherapy in esophageal cancer. (dovepress.com)
  • Although concurrent chemoradiotherapy was the standard care for locally advanced esophageal cancer, radiotherapy was the choice for those who were refused or could not tolerate chemoradiotherapy. (dovepress.com)
  • Our study shows that nimotuzumab combined with radiotherapy was well tolerated in patients with esophageal cancer. (dovepress.com)
  • Using a multi-disciplinary approach, Esophageal Cancer: Principles and Practice addresses the complexities encountered in the understanding and management of esophageal cancers. (springerpub.com)
  • In Brazil, esophageal cancer is the 10th more common neoplasia, with high mortality rate due to the delayed diagnosis. (scielo.br)
  • Expert-reviewed information summary about the treatment of esophageal cancer. (oncolink.org)
  • This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of esophageal cancer. (oncolink.org)
  • The incidence of esophageal cancer has risen in recent decades, coinciding with a shift in histologic type and primary tumor location. (oncolink.org)
  • In the United States, the median age of patients who present with esophageal cancer is 67 years. (oncolink.org)
  • Refer to the PDQ summary on Esophageal Cancer Prevention for more information. (oncolink.org)
  • Patients with severe dysplasia in distal esophageal Barrett mucosa often have or invasive cancer within the dysplastic area. (oncolink.org)
  • In most cases, esophageal cancer is a treatable disease, but it is rarely curable. (oncolink.org)
  • Early gastro-esophageal cancer is staged as m1 to m3 depending on the infiltration of the anatomical layers of the mucosa or, analogously, as sm1 to sm3 depending on the depth of infiltration into the submucosa. (aerzteblatt.de)
  • New technologies such as narrow-band imaging have improved the endoscopic diagnosis and staging of early gastro-esophageal cancer. (aerzteblatt.de)
  • In esophageal adenocarcinoma, the prevalence of lymph node metastases is low if the cancer is restricted to the mucosa and increases only when the submucosa is infiltrated. (aerzteblatt.de)
  • Esophageal cancer treatment options include surgery alone for very early disease and add chemotherapy and radiation therapy for more advanced cases. (oncolink.org)
  • Get detailed information about the treatment of newly diagnosed and recurrent esophageal cancer in this summary for clinicians. (oncolink.org)
  • PURPOSE The correlation between radiation dose and loco-regional control (LRC) was evaluated in patients with stage II-III esophageal cancer treated with definitive concurrent chemoradiotherapy (CRT). (semanticscholar.org)
  • MATERIALS AND METHODS Medical records of 236 stage II-III esophageal cancer patients treated with definitive CRT at Yonsei Cancer Center between 1994 and 2013 were retrospectively reviewed. (semanticscholar.org)
  • Early surgery for failure after chemoradiation in operable thoracic oesophageal cancer. (semanticscholar.org)
  • High-dose versus conventional-dose irradiation in cisplatin-based definitive concurrent chemoradiotherapy for esophageal cancer: a systematic review and pooled analysis. (semanticscholar.org)
  • High-dose versus standard-dose radiotherapy with concurrent chemotherapy in stages II-III esophageal cancer. (semanticscholar.org)
  • High-dose definitive concomitant chemoradiotherapy in non-metastatic locally advanced esophageal cancer: toxicity and outcome. (semanticscholar.org)
  • Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781. (semanticscholar.org)
  • Oesophageal cancer is the eighth most common malignancy worldwide, with an annual incidence of over 500,000 [1] . (plos.org)
  • Of the various histological subtypes of oesophageal cancer, oesophageal squamous cell carcinoma (OSCC) accounts for a majority and is predominant in developing countries [2] . (plos.org)
  • A case-control study of esophageal cancer. (cdc.gov)
  • Results are reported from a nested case-control study of 60 esophageal cancer deaths among 46,384 automobile manufacturing workers potentially exposed to metalworking fluid s (MWF) in machining and grinding operations. (cdc.gov)
  • RESULTS: Esophageal cancer was found to be significantly associated with exposure to both soluble and synthetic MWF in grinding operations. (cdc.gov)
  • Those with 12 or more years exposure to soluble MWF in grinding operations experienced a 9.3-fold relative risk of esophageal cancer mortality (95% CI = 2.1-42.1). (cdc.gov)
  • Esophageal cancer is one of the ten most common malignancies worldwide. (bioline.org.br)
  • 2 Surgery is the treatment of choice for most localized esophageal cancer patients. (bioline.org.br)
  • 3,4 Despite improvements in surgical techniques and reduction in post-operative mortality the overall outcome in esophageal cancer is poor with only 10% of patients surviving five years post-diagnosis. (bioline.org.br)
  • Purposes of the current study were to evaluate the changing incidence rates of oesophageal and gastric cardia cancer, and to assess survival trends. (eur.nl)
  • The increased survival for oesophageal carcinoma can be attributed to centralisation of surgery, and an increased use of multimodality therapy, factors hardly acknowledged for gastric cancer. (eur.nl)
  • IGFBP-3 is overexpressed frequently in esophageal cancer. (elsevier.com)
  • Esophageal cancer remains one of the deadliest gastrointestinal malignancies. (elsevier.com)
  • Single modality therapy for esophageal cancer usually consists of surgery or radiation therapy. (elsevier.com)
  • Numerous questions remain regarding the most efficacious treatment of nonmetastatic esophageal cancer, and further study is required to identify the ideal treatment. (elsevier.com)
  • Supraclavicular node metastasis is common in patients with esophageal cancer. (springermedizin.at)
  • Esophageal cancer: results of an American College of Surgeons Patient Care Evaluation Study. (springermedizin.at)
  • Dissection of lymph node metastases in esophageal cancer. (springermedizin.at)
  • Prognostic impact of the 6th and 7th American Joint Committee on Cancer TNM staging systems on esophageal cancer patients treated with chemoradiotherapy. (springermedizin.at)
  • Nodal metastasis from locally advanced esophageal cancer: how neoadjuvant therapy modifies their frequency and distribution. (springermedizin.at)
  • Dr. Healy frequently treats Benign Neoplasm of the Digestive System , Collapsed Lung (Pneumothorax), and Esophageal Cancer. (healthgrades.com)
  • Background/Aim: Ras-related associated with diabetes (RRAD), a member of the Ras-related GTPase superfamily, is frequently methylated in several human cancers, though its methylation profile remains unclear in esophageal cancer. (elsevier.com)
  • These techniques may finally allow the interventional gastrointestinal endoscopist to prevent the development of esophageal carcinoma, just as colonoscopy with polypectomy has prevented colon cancer. (elsevier.com)
  • Wolfsen, HC 2005, ' Endoprevention of esophageal cancer: Endoscopic ablation of Barrett's metaplasia and dysplasia ', Expert Review of Medical Devices , vol. 2, no. 6, pp. 713-723. (elsevier.com)
  • Consecutive research on RIPs and its relationship with malignant digestive neoplasms is required, as it ultimately conduces to the etiology and treatment of cancer. (jcancer.org)
  • 50% of aero digestive fistula are secondary to malignant neoplasms and 4.5% of patients with esophageal cancer will develop one during their disease course. (elsevier.es)
  • We present a case of second primary early cervical esophageal squamous cell cancer managed by local resection with reconstruction using a radial forearm flap. (elsevier.com)
  • A neoplasm can be benign , potentially malignant, or malignant ( cancer ). (wikipedia.org)
  • Malignant neoplasms are commonly called cancer. (wikipedia.org)
  • Secondary neoplasm refers to any of a class of cancerous tumor that is either a metastatic offshoot of a primary tumor, or an apparently unrelated tumor that increases in frequency following certain cancer treatments such as chemotherapy or radiotherapy . (wikipedia.org)
  • However, ESD may cause difficult-to-treat stricture of the esophagus, and therefore, prediction of and measures against postoperative esophageal stricture are critical. (ovid.com)
  • Furthermore, in 45 subjects with resection of >75% of the esophageal circumference, whole resection of the esophagus was the only independent risk factor for stricture. (ovid.com)
  • however, a greater extent of resection of the esophagus increases the risk of postoperative esophageal stricture. (ovid.com)
  • Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the use of this procedure in the esophagus. (elsevier.com)
  • Furthermore, the lumen of the esophagus is narrow, and, therefore, post-ESD esophageal strictures occur more frequently than strictures in the stomach. (e-ce.org)
  • A pathological condition characterized by the presence of a number of ESOPHAGEAL DIVERTICULA in the ESOPHAGUS. (bioportfolio.com)
  • Circular innermost layer of the ESOPHAGUS wall that mediates esophageal PERISTALSIS which pushes ingested food bolus toward the stomach. (bioportfolio.com)
  • Barrett's esophagus is a uniquely suited model to investigate neoplastic progression prospectively because periodic endoscopic biopsy surveillance is recommended for early detection of esophageal adenocarcinoma. (aacrjournals.org)
  • While risk factors for squamous cell carcinoma of the esophagus have been identified (such as tobacco, alcoholism, malnutrition, and infection with human papillomavirus),[ 5 ] the risk factors associated with esophageal adenocarcinoma are less defined. (cancer.gov)
  • 1 ] Gastroesophageal reflux/Barrett esophagus is associated with an increased risk of esophageal adenocarcinoma. (adventisthealthcare.com)
  • Other factors that may explain the increased risk of adenocarcinoma of the esophagus include obesity [ 2 ] and the use of medications such as anticholinergics that can predispose to gastroesophageal reflux disease (GERD) by relaxing the lower esophageal sphincter. (adventisthealthcare.com)
  • NMBA is an asymmetrical nitrosamine that readily induces mutagenic, toxic, and carcinogenic effects in esophageal tissues and is the most potent nitrosamine carcinogen for the rat esophagus ( 4 , 5 ). (aacrjournals.org)
  • Its clinical and radiological manifestations are similar to other esophageal tumors. (amegroups.com)
  • Distal esophageal tumors and gastric cardia tumors, although only physically separated by centimeters, have different staging systems and are usually treated differently. (nih.gov)
  • We hypothesized that gastroesophageal junction adenocarcinomas (eg, gastric cardia and distal esophageal tumors) were not distinct entities and had similar survival. (nih.gov)
  • Of 40 lesions occurring in 31 patients fulfilling the criteria of node-negative tumors (mean follow-up, 17 months), 1 lesion resected by en bloc resection with nonevaluable tumor-free lateral margins (Rx [lateral] resection) recurred locally 6 months after ESD, which was treated successfully by a second ESD procedure. (elsevier.com)
  • In the 1960s, squamous cell cancers comprised more than 90% of all esophageal tumors. (cancer.gov)
  • In the fifties, the adenocarcinoma represented less than 5% of the esophageal tumors in the United States and Europe (4) . (scielo.br)
  • We report a case of synchronous supraglottic and esophageal SCC primary tumors, highlighting treatment with a monoisocentric hybrid radiation technique and normal tissue toxicity considerations. (frontiersin.org)
  • Endoscopic submucosal dissection (ESD) enables wider tumor resection compared with endoscopic mucosal resection and en bloc resection of superficial esophageal neoplasms. (ovid.com)
  • Comparison of the 22 subjects with stricture with the 98 subjects without stricture showed significant differences in the rate of resection of >75% of the esophageal circumference, rate of whole circumference resection, and the required time for resection. (ovid.com)
  • Aims To review the effectiveness of the revised Vienna classification (rVC) at predicting histological outcome and defining the postendoscopic resection (ER) clinical management plan of gastro-oesophageal dysplasia and early neoplasia in a UK tertiary-centre population. (bmj.com)
  • Main Outcome Measurements: Rates of en bloc resection, complete resection, and complication were evaluated as short-term outcomes. (elsevier.com)
  • Results: The rates of en bloc resection and complete resection were 100% and 88%, respectively. (elsevier.com)
  • Particularly, a more substantial number of old sufferers qualified to receive esophageal resection are contra-indicated based on the aggressiveness from the medical procedures. (barasertib.info)
  • Background & Aims: Endoscopic submucosal dissection (ESD) has recently been developed for en bloc resection of stomach neoplasms, which results in high tumor eradication rates as well as a modality for the precise histologic assessment of the entire lesion. (elsevier.com)
  • Results: The rate of en bloc resection was 100% (58/58), and en bloc resection with tumor-free lateral/basal margins (R0 resection) was 78% (45/58). (elsevier.com)
  • Endoscopic submucosal dissection (ESD) allows for high rates of en bloc resection, precise histological assessment, and low rates of local recurrence. (e-ce.org)
  • The en bloc resection and R0 resection rates were 97.2% (35 of 36) and 91.7% (33 of 36), respectively. (e-ce.org)
  • According to recent data, endoscopic treatment is more effective and safer than surgical resection of superficial esophageal neoplasms [ 6 , 11 ]. (e-ce.org)
  • Endoscopic resection (ER) of superficial esophageal neoplasm (SEN) is a technically difficult procedure . (bvsalud.org)
  • Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan," Gastrointestinal Endoscopy , vol. 68, no. 6, pp. 1066-1072, 2008. (hindawi.com)
  • Radiation therapy for the supraclavicular lymph node metastasis after curative resection of the esophageal carcinoma. (springermedizin.at)
  • Consensus is lacking among surgeons regarding closure of the esophageal muscle layer after resection of an esophageal duplication cyst and long-term outcomes are poorly documented. (bireme.br)
  • Therefore, we conducted the first study comparing complication rates in patients undergoing closure versus nonclosure of the esophageal muscle layer after esophageal duplication cyst resection. (bireme.br)
  • Patients undergoing resection of esophageal duplication cysts between 1990 and 2012 were classified according to whether the esophageal muscle layer was closed or left open. (bireme.br)
  • Able to insert the intra-esophageal applicator (Dilatation is allowed to open up the tumor/lumen to facilitate insertion, and this does not preclude eligibility. (knowcancer.com)
  • Yet, the role of IGFBP-3 in esophageal tumor biology remains elusive. (elsevier.com)
  • In aggregate, these data suggest that IGFBP-3 contributes to esophageal tumor development and progression through IGF-dependent and independent mechanisms. (elsevier.com)
  • Tumor registry files identified I additional male with brain metastasis from an undifferentiated esophageal neoplasm. (ajnr.org)
  • Strong impact of micrometastatic tumor cell load in patients with esophageal carcinoma. (springermedizin.at)
  • Esophageal tissues were collected, and tumor data were recorded. (aacrjournals.org)
  • Neoplasm is an abnormal growth of tissue which, if it forms a mass, is commonly referred to as a tumor . (wikipedia.org)
  • Current English, however, both medical and non-medical, uses tumor as a synonym for a neoplasm (a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears enlarged in size. (wikipedia.org)
  • Although leiomyoma is the most common benign esophageal tumor, malignant carcinoma is still 50 times more likely. (wikipedia.org)
  • The protective effect of H. pylori was more pronounced for oesophageal adenocarcinoma (seven cases, odds ratio 0.16, 95% CI: 0.00-1.06) than for squamous-cell carcinoma (29 cases, odds ratio 0.41, 95% CI: 0.14-1.2). (nih.gov)
  • Leptomeningeal carcinomatosis associated with oesophageal adenocarcinoma: two case reports and review of the literature. (biomedsearch.com)
  • We report two cases of leptomeningeal carcinomatosis in patients with oesophageal adenocarcinoma. (biomedsearch.com)
  • The minimal invasiveness of endoscopic submucosal dissection (ESD) prompted us to apply this technique to large-size early esophageal squamous cell carcinoma and Barrett's adenocarcinoma, despite the limitations in the study population and surveillance duration. (elsevier.com)
  • We hypothesized that expansion of clones with genetic instability would predict progression to esophageal adenocarcinoma. (aacrjournals.org)
  • The size of a clone with a p16 lesion is not a significant predictor of esophageal adenocarcinoma when we controlled for p53 loss of heterozygosity status. (aacrjournals.org)
  • Two histologic types account for the majority of malignant esophageal neoplasms: adenocarcinoma and squamous carcinoma. (cancer.gov)
  • The results of a population-based case-control study suggest that symptomatic gastroesophageal reflux is a risk factor for esophageal adenocarcinoma. (cancer.gov)
  • The frequency, severity, and duration of reflux symptoms were positively associated with increased risk of esophageal adenocarcinoma. (cancer.gov)
  • An interesting hypothesis relates the rise in incidence of esophageal adenocarcinoma to a declining prevalence of Helicobacter pylori infection in Western countries. (cancer.gov)
  • Past use of lower esophageal sphincter (LES)-relaxing drugs was positively associated with risk of esophageal adenocarcinoma. (cancer.gov)
  • Gastric cardia adenocarcinoma and esophageal squamous cell carcinoma were not associated with use of LES-relaxing drugs. (cancer.gov)
  • Risk factors associated with esophageal adenocarcinoma are less clear. (oncolink.org)
  • The results of a population-based, case-controlled study from Sweden strongly suggest that symptomatic gastroesophageal reflux is a risk factor for esophageal adenocarcinoma. (oncolink.org)
  • Introduction: A worldwide increasing incidence is seen for oesophageal adenocarcinoma, but not for oesophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma. (eur.nl)
  • Patients and methods: Patients diagnosed with oesophageal adenocarcinoma (N = 12,195) or SCC (N = 9046), or gastric cardia adenocarcinoma (N = 9900) between 1989 and 2008 in the Netherlands were included. (eur.nl)
  • Discussion: In the Netherlands, a rising incidence is seen for oesophageal adenocarcinoma, but not for gastric cardia adenocarcinoma. (eur.nl)
  • Esophageal carcinoma metastatic to the brain: clinical value and cost-effectiveness of routine enhanced head CT before esophagectomy. (ajnr.org)
  • Altorki N, Skinner D. Should en bloc esophagectomy be the standard of care for esophageal carcinoma? (springermedizin.at)
  • Background: The long-term outcomes of endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell neoplasms (ESCNs) have not been evaluated to date. (elsevier.com)
  • See the reply "Endoscopic Submucosal Dissection for Superficial Esophageal Neoplasm: A Growing Body of Evidence" on page 101. (e-ce.org)
  • Pneumomediastinum is a frequent but minor complication during esophageal endoscopic submucosal dissection," Endoscopy , vol. 42, no. 1, pp. 8-14, 2010. (hindawi.com)
  • Mediastinal emphysema after esophageal endoscopic submucosal dissection: its prevalence and clinical significance," Digestive Endoscopy , vol. 23, no. 3, pp. 221-226, 2011. (hindawi.com)
  • Risk factors for Mallory-Weiss Tear during endoscopic submucosal dissection of superficial esophageal neoplasms. (wjgnet.com)
  • At the junction with the stomach is the lower esophageal sphincter, which relaxes to permit passage of food, then contracts to prevent backup of stomach contents. (thefreedictionary.com)
  • Parenteral glucagon may help the material pass through the esophageal sphincter to the stomach, but endoscopic retrieval of the material is usually necessary. (thefreedictionary.com)
  • Hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) occurs as a rare but clinically important phenomena in various conditions including malignant neoplasms، infections، and central nervous system disorders، and as an adverse effect of numerous drugs. (magiran.com)
  • Esophageal squamous cell carcinoma (SCC) is one of the most common malignant neoplasms worldwide. (aacrjournals.org)
  • benign neoplasms , in situ neoplasms , malignant neoplasms , and neoplasms of uncertain or unknown behavior. (wikipedia.org)
  • [5] Malignant neoplasms are also simply known as cancers and are the focus of oncology . (wikipedia.org)
  • Potentially-malignant neoplasms include carcinoma in situ . (wikipedia.org)
  • Surgical incision of the lower esophageal sphincter near the CARDIA often used to treat ESOPHAGEAL ACHALASIA. (bioportfolio.com)
  • This new method is useful for detailed evaluation of early flat squamous cell neoplasms. (bvsalud.org)
  • Endoscopy with ultrasound noted a mucosa-confined esophageal mass, extending from 20 to 22 cm from the incisors. (frontiersin.org)
  • We present our initial experience with a new biodegradable (BD) esophageal stent in two patients, one for a therapy-resistant benign esophageal stricture, and the other as a temporary measure during curative radiotherapy for oesophageal carcinoma. (springer.com)
  • Zhong J, Wu Y, Xu Z, Liu X, Xu B, Zhai Z (2003) Treatment of medium and late stage esophageal carcinoma with combined endoscopic metal stenting and radiotherapy. (springer.com)
  • Iraha Y, Murayama S, Toita T et al (2006) Self-expandable metallic stent placement for patients with inoperable esophageal carcinoma: investigation of the influence of prior radiotherapy and chemotherapy. (springer.com)
  • The aim of this study was to identify the long-term clinical outcome of definitive radiotherapy using three-dimensional conformal radiotherapy (3DCRT) for cervical esophageal squamous cell carcinoma (CESCC). (biomedcentral.com)
  • Radiotherapy is a definitive treatment for cervical esophageal squamous cell carcinoma (CESCC). (biomedcentral.com)
  • To delineate the functional consequences of IGFBP-3 overexpression, we stably transduced Ha-Ras V12 -transformed human esophageal cells with either wild-type or mutant IGFBP-3, the latter incapable of binding Insulin-like growth factor (IGFs) as a result of substitution of amino-terminal Ile 56 , Leu 80 , and Leu 81 residues with Glycine residues. (elsevier.com)
  • Materials and Methods: We examined RRAD promoter hypermethylation using real-time quantitative methylation-specific PCR in 229 primary human esophageal tissues of contrasting histological types. (elsevier.com)
  • Our laboratory has used a rodent model of human esophageal squamous cell carcinoma to identify putative chemopreventive agents for this disease and to determine their mechanisms of action. (aacrjournals.org)
  • We examined DPC4 mutation in 30 examples of three other types of gastrointestinal malignancy: 10 esophageal cancers, 10 gastric cancers and 10 colorectal cancers occurring in the preneoplastic condition, ulcerative colitis. (nih.gov)
  • Background: However the prevalence of esophageal cancers increases in older sufferers, its clinical history and final result after treatment stay defined poorly. (barasertib.info)
  • Les cancers de l' oesophage en 1984 : 135 questions, recueil des communications du Premier Congrès international polydisciplinaire, Paris, 17, 18, 19 mai 1984 / sous la direction de R. Giuli. (who.int)
  • This Phase II clinical trial involved 42 patients with stage II (inoperable or refused surgery) to stage IV (supraclavicular lymph node metastasis only) esophageal cancers treated between November 2008 and July 2010. (dovepress.com)
  • Biopsy of the esophageal mass showed invasive SCC and the patient was ultimately diagnosed with cT3N2cM0 (stage IVA) and uT1bN1M0 (stage IIB) supraglottic and esophageal cancers, respectively. (frontiersin.org)
  • Despite the continued decline in incidence of esophageal squamous cell carcinoma (ESCC) in the United States, the rate of synchronous primary head and neck squamous cell carcinoma (HNSCC) and ESCC remains relatively unchanged over the past two decades ( 1 , 2 ). (frontiersin.org)
  • 0.001), while the incidence for oesophageal SCC remained stable in males (-0.2%, P = 0.6) and slightly increased in females (+1.7%, P = 0.001). (eur.nl)
  • In Linxian, China, the region with the highest incidence of esophageal SCC in the world, NMBA was identified in pickled vegetables and its metabolism has been elucidated ( 6 , 7 ). (aacrjournals.org)
  • Through a large, population-based analysis of gastric cardia and distal esophageal adenocarcinomas, we found that patients with gastroesophageal junction adenocarcinomas have similar survival rates. (nih.gov)
  • Treatment is by surgical repair by esophageal anastomosis and division of the fistula. (thefreedictionary.com)
  • Surgical pathology files identified 293 additional esophageal carcinomas, including 2 males with adenocarcinomas metastatic to brain. (ajnr.org)
  • Early surgical removal of intramural esophageal neoplasms with potentially malignant features is highly recommended. (medworm.com)
  • During the median observation of 632 days (range 8-2358), 15 (18%) patients experienced benign esophageal stricture with dysphagia, which was successfully managed by balloon dilation for a median of 2 sessions (range 1-20). (elsevier.com)
  • Fry SW, Fleischer DE (1997) Management of a refractory benign esophageal stricture with a new biodegradable stent. (springer.com)
  • In a multivariate model, with adjustment for occupation, tobacco and alcohol consumption, the odds ratio for developing an oesophageal malignancy when infected with H. pylori was 0.29 (95% confidence interval (CI): 0.12-0.67). (nih.gov)
  • Helicobacter pylori infection is associated with a decreased risk of developing an oesophageal malignancy. (nih.gov)
  • Esophageal sarcomatoid carcinoma (ESC) is a rare malignancy, accounting for about 2% of esophageal malignancies. (amegroups.com)
  • Histopathology findings of the resected specimen revealed squamous intraepithelial neoplasia at the 4 o'clock position and an esophageal squamous cell carcinoma in the remaining iodine-unstained area. (bvsalud.org)
  • Background & Aims: Esophageal squamous cell neoplasia has a high mortality rate as a result of late detection. (rice.edu)
  • Conclusions: In this trial, HRME improved the accuracy of LCE for esophageal squamous cell neoplasia screening and surveillance. (rice.edu)
  • Radical and/or repeated esophageal resections are the only known therapies with curative potential. (medworm.com)
  • Superficial esophageal neoplasm pathology diagnosis and therapy superficial esophageal carcinomas associated with superficial esophageal neoplasm. (dissonant.ca)
  • Encuentra superficial esophageal neoplasm pathology diagnosis and therapy de m imamura isbn 9784431679974 en amazon envos gratis a partir de 19eur. (dissonant.ca)
  • The aim of this study was to evaluate the effect of ESD on superficial esophageal neoplasms and identify risk factors associated with esophageal stricture after ESD. (ovid.com)
  • Both the diagnosis and treatment of common and uncommon manifestations of esophageal disorders are covered in-depth, with each disorder illustrated by representative images supported by succinct explanatory text. (pluralpublishing.com)
  • Removal of 9 (16%) lesions resulted in esophageal stricture requiring balloon dilation after ESD. (elsevier.com)
  • Benign esophageal lesions are less symptomatic than malignant esophageal lesions , making up for only 1% of clinically apparent esophageal lesions. (radiopaedia.org)
  • The spectrum of benign esophageal lesions: imaging findings. (radiopaedia.org)
  • For lymphoid neoplasms, e.g. lymphoma and leukemia , clonality is proven by the amplification of a single rearrangement of their immunoglobulin gene (for B cell lesions) or T cell receptor gene (for T cell lesions). (wikipedia.org)
  • Authors: Asai S, Fukaya M, Fujieda H, Igami T, Tsunoda N, Sakatoku Y, Kamei Y, Miyata K, Nagino M Abstract A 71-year-old woman with dysphagia was diagnosed with thoracic esophageal squamous cell carcinoma by endoscopic biopsy at another hospital. (medworm.com)
  • abstract = "Background/Aims: Endoscopic treatment has been broadly applied to superficial esophageal neoplasms. (elsevier.com)
  • abstract = "This review describes the use of endoscopic therapy for the treatment of Barrett's disease and the prevention of esophageal carcinoma, predominantly a disease of older white men. (elsevier.com)
  • Effectiveness of bougie dilation for the management of corrosive esophageal strictures. (biomedsearch.com)
  • Song HY, Park SI, Do YS et al (1997) Expandable metallic stent placement in patients with benign esophageal strictures: results of long-term follow-up. (springer.com)
  • Cwikiel W, Willen R, Stridbeck H, Lillo-Gil R, von Holstein CS (1993) Self-expanding stent in the treatment of benign esophageal strictures: experimental study in pigs and presentation of clinical cases. (springer.com)
  • Dua KS, Vleggaar FP, Santharam R, Siersema PD (2008) Removable self-expanding plastic esophageal stent as a continuous, non-permanent dilator in treating refractory benign esophageal strictures: a prospective two-center study. (springer.com)
  • Siersema PD (2008) Treatment options for esophageal strictures. (springer.com)
  • Repici A, Conio M, De Angelis C et al (2004) Temporary placement of an expandable polyester silicone-covered stent for treatment of refractory benign esophageal strictures. (springer.com)
  • Siersema PD (2009) Stenting for benign esophageal strictures. (springer.com)
  • A post-ESD ulceration of greater than three-fourths of esophageal circumference was advocated as an important risk factor for refractory strictures that require several sessions of dilation therapy. (elsevier.com)
  • Definitive chemoradiation (CRT) is standard care for locally advanced HNSCC and is a preferred option for inoperable esophageal SCC. (frontiersin.org)
  • Methods: We retrospectively reviewed 36 esophageal ESDs for superficial squamous neoplasms in 32 patients between March 2009 and August 2014 at Gangnam Severance Hospital. (elsevier.com)
  • METHODS Thoracic surgery files of patients undergoing esophagectomies for squamous carcinomas, adenocarcinomas, and undifferentiated carcinomas between January 1984 and March 1993 were reviewed regarding sex, size (length) of neoplasm, and brain metastases. (ajnr.org)
  • We investigated BRCA2 germline mutations in familial clusters with esophageal squamous cell carcinoma (ESCC). (medscimonit.com)
  • Surgery is the treatment of choice for localized esophageal squamous cell carcinoma (ESCC). (bioline.org.br)
  • This research investigated the frequency of supraclavicular node metastasis in patients with esophageal squamous cell carcinoma (ESCC), identified the factors correlated with supraclavicular node metastasis, and evaluated the clinical relevance of supraclavicular node metastasis in thoracic ESCC. (springermedizin.at)
  • Whether nutritional assessment and management improves clinical outcomes in patients with clinical T1N0M0 esophageal squamous cell carcinoma (ESCC) who undergo chemoradiotherapy remains to be demonstrated. (dovepress.com)
  • Five-year survival for both M0 and M1 oesophageal carcinoma doubled over the last 20 years. (eur.nl)
  • CONCLUSION: Esophageal MGCT requires a detailed presentation including long-term survival. (medworm.com)
  • Histological typing of gastric and oesophageal tumours / H. Watanabe, J. R. Jass and L. H. Sobin, in collaboration with pathologists in 8 countries. (who.int)
  • LCI and BLI combined with iodine staining produce characteristic images that overcomes the pink-color sign, reflecting the histological features of a flat esophageal neoplasm. (bvsalud.org)
  • Oesophageal haemangiomas are rare, benign, vascular tumours that have characteristic features on computed tomography and magnetic resonance imaging. (hkmj.org)
  • The data of 3,714 patients with thoracic esophageal carcinoma from Apr, 1979 to Dec. 1994 were analysed in purpose to estimate the value of cervical esophagogastrotomy (cervical reconstruction) in the treatment of thoracic esophageal carcinoma. (springer.com)
  • Lymph node metastasis in thoracic esophageal carcinoma. (springer.com)
  • Shin JH, Song HY, Kim JH et al (2005) Comparison of temporary and permanent stent placement with concurrent radiation therapy in patients with esophageal carcinoma. (springer.com)
  • Ultrasound and ultrasound-guided fine needle aspiration biopsy of supraclavicular lymph nodes in patients with esophageal carcinoma. (springermedizin.at)