DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsHealth Care
Erythromycin EstolateErythromycin EthylsuccinateErythromycinPainPain ManagementChronic PainPain MeasurementDentistryPain ThresholdPain, Postoperative
Erythromycin Estolate
A macrolide antibiotic, produced by Streptomyces erythreus. It is the lauryl sulfate salt of the propionic ester of erythromycin. This erythromycin salt acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Erythromycin Ethylsuccinate
A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Erythromycin
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Pain Management
A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing pain.
Chronic Pain
Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
Pain Measurement
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Dentistry
The profession concerned with the teeth, oral cavity, and associated structures, and the diagnosis and treatment of their diseases including prevention and the restoration of defective and missing tissue.
Pain Threshold
Amount of stimulation required before the sensation of pain is experienced.
Pain, Postoperative
Pain during the period after surgery.

Use of erythromycin for the treatment of severe chronic constipation in children. (1/11)

The efficacy of erythromycin was assessed in the treatment of 14 children aged 4 to 13 years with refractory chronic constipation, and presenting megarectum and fecal impaction. A double-blind, placebo- controlled, crossover study was conducted at the Pediatric Gastroenterology Outpatient Clinic of the University Hospital. The patients were randomized to receive placebo for 4 weeks followed by erythromycin estolate, 20 mg kg-1 day-1, divided into four oral doses for another 4 weeks, or vice versa. Patient outcome was assessed according to a clinical score from 12 (most severe clinical condition) to 0 (complete recovery). At enrollment in the study and on the occasion of follow-up medical visits at two-week intervals, patient score and laxative requirements were recorded. During the first 30 days, the mean SD clinical score for the erythromycin group (N = 6) decreased from 8.2+/-2.3 to 2.2+/-1.0 while the score for the placebo group (N = 8) decreased from 7.8+/-2.1 to 2.9+/-2.8. During the second crossover phase, the score for patients on erythromycin ranged from 2.9+/-2.8 to 2.4+/-2.1 and the score for the patients on placebo worsened from 2.2+/-1.0 to 4.3+/-2.3. There was a significant improvement in score when patients were on erythromycin (P < 0.01). Mean laxative requirement was lower when patients ingested erythromycin (P < 0.05). No erythromycin-related side effects occurred. Erythromycin was useful in this group of severely constipated children. A larger trial is needed to fully ascertain the prokinetic efficacy of this drug as an adjunct in the treatment of severe constipation in children.  (+info)

Comparison of the effects of the new azalide antibiotic, azithromycin, and erythromycin estolate on rat liver cytochrome P-450. (2/11)

Erythromycin and some other macrolide antibiotics can first induce a cytochrome P-450 isozyme similar to the one induced in rats by pregnenolone-16 alpha-carbonitrile and then inhibit it by forming a stable cytochrome P-450-metabolite complex. The purpose of this study was to compare azithromycin, a novel 15-membered ring azalide, and erythromycin estolate for the potential to cause hepatic microsomal enzyme induction and inhibition in Sprague-Dawley rats. The daily oral administration of 800 mg of erythromycin estolate per kg for 7 days resulted in statistically significant elevations of NADPH-cytochrome c reductase, erythromycin N-demethylase (3.2-fold), and total cytochrome P-450 content. Approximately 40% of cytochrome P-450 was complexed with erythromycin metabolite. In contrast, the daily administration of 200 mg of azithromycin per kg for 7 days caused significant elevations of N-demethylase (2.5-fold) only and did not produce any increases in total cytochrome P-450 content or NADPH-cytochrome c reductase. No complexed cytochrome P-450 was detected in the azithromycin-dosed rats despite liver concentrations of azithromycin that were 118 times greater than the liver concentrations of erythromycin estolate in erythromycin estolate-dosed rats. Although the short-term oral administration of azithromycin produced hepatic accumulation of the drug and elevated azithromycin demethylase activity, there was no other evidence of hepatic cytochrome P-450 induction or inactivation via cytochrome-metabolite complex formation. In contrast to erythromycin estolate, azithromycin is not expected to inhibit its own metabolism or that of other drugs via this pathway.  (+info)

Hepatotoxicity of erythromycin estolate during pregnancy. (3/11)

Women in the second half of pregnancy, who were infected with genital mycoplasmas and who gave written informed consent, were randomly assigned to receive capsules of identical appearance containing erythromycin estolate, clindamycin hydrochloride, or a placebo for 6 weeks. Levels of serum glutamic oxalacetic transaminase (SGOT) were determined before and during treatment by a fluorometric method. All pretreatment levels of SGOT were normal (<41 units). Participants who received erythromycin estolate had significantly more abnormally elevated levels of SGOT (16/161, 9.9%) than did those who received clindamycin (4/168, 2.4%, P < 0.01) or those who received placebo (3/165, 1.8%, P < 0.01). Elevated levels of SGOT ranged from 44 to 130 U. Serum bilirubin levels were normal. Gamma-glutamyl transpeptidase activity was abnormal in six of six participants who had abnormal levels of SGOT while receiving erythromycin estolate. There were few associated symptoms, and all levels of SGOT returned to normal after cessation of treatment. The treatment of pregnant women with erythromycin estolate may be inadvisable.  (+info)

Effects of a new fluorinated macrolide (P-0501A) and other erythromycins on drug metabolizing enzymes in rat liver. (4/11)

The effects of a new fluorinated macrolide (P-0501A) on drug metabolizing enzymes of rat liver were compared with three erythromycins--the base, the stearate and the estolate--after 7 days of dosing (1.36 mmol/kg po daily). The three erythromycins induced the synthesis of microsomal enzymes, but the products of their metabolism inactivated cytochrome P-450 in the order base less than or equal to stearate less than estolate. N-Demethylation of erythromycin and aminopyrine increased, while O-demethylation of 4-nitroanisole was reduced and hydroxylation of aniline was not changed after in vivo treatment. Pentobarbital sleeping time was prolonged and liver glutathione levels were lower in treated rats than in controls. In contrast to the three erythromycins, P-0501A did not induce the synthesis of microsomal enzymes, did not form an inactive complex with cytochrome P-450 and did not affect mono-oxygenase activities or pentobarbital narcosis.  (+info)

Plasma bactericidal activity after administration of erythromycin estolate and erythromycin ethylsuccinate to healthy volunteers. (5/11)

In a crossover design study, we compared the plasma bactericidal activities of erythromycin estolate (500 mg) and erythromycin ethylsuccinate (600 mg) after administration of a single oral dose to 12 healthy volunteers. Both erythromycin esters displayed very good plasma bactericidal activities against Streptococcus pneumoniae. The median bactericidal titers produced in plasma against Streptococcus pyogenes and Streptococcus pneumoniae were significantly higher with erythromycin estolate than with the ethylsuccinate ester at both 2 and 8 h after dosing (P less than 0.05 by Student's t test). Both erythromycin esters showed rather weak bactericidal activity against Branhamella catarrhalis; a further look at these results indicated that erythromycin estolate presented 50% of the plasma samples at 2 h with bactericidal titers superior or equal to 1:8, versus 11% for the ethylsuccinate ester. Of the 60 plasma bactericidal activity tests performed against Staphylococcus aureus, only 6 (10%) and 3 (5%) exhibited titers of 1:8 or greater for erythromycin estolate and erythromycin ethylsuccinate, respectively. Clinical trials are warranted in which these products are compared in infections other than Streptococcus pyogenes pharyngitis, for which the clinical superiority of erythromycin estolate has been demonstrated.  (+info)

Toxicity, uptake, and subcellular distribution in rat hepatocytes of roxithromycin, a new semisynthetic macrolide, and erythromycin base. (6/11)

Rat hepatocytes were used to study the toxicity of a new semisynthetic macrolide, roxithromycin, in comparison with erythromycin base and erythromycin estolate. Roxithromycin caused lactate dehydrogenase leakage close to that of erythromycin estolate and higher than erythromycin base after 21 h of exposure to the drugs. This effect was, at least in part, explained by the higher uptake: roxithromycin was two to three times more concentrated by liver cells than erythromycin base. For both roxithromycin and erythromycin base, the uptake depended on time, temperature, and extracellular antibiotic concentration. The accumulated macrolides egressed rapidly when cells were incubated in antibiotic-free medium. No uptake and no loss of accumulated drugs were observed at 4 degrees C. After accumulation by hepatocytes, roxithromycin and erythromycin base underwent similar subcellular distribution, mostly concentrating in cytosol and lysosomes. The small amount accumulated in the other particulate fractions followed the order mitochondria much greater than nuclei greater than microsomes. Roxithromycin, however, was less concentrated than erythromycin base in the microsomes.  (+info)

Pharmacokinetic advantages of erythromycin estolate over ethylsuccinate as determined by high-pressure liquid chromatography. (7/11)

The pharmacokinetics of erythromycin estolate (500 mg) and erythromycin ethylsuccinate (600 mg) were compared in 12 healthy volunteers after single doses and after repeated oral doses (every 8 h). High-pressure liquid chromatography with electrochemical detection was used to determine concentrations in plasma and urine of estolate, ethylsuccinate, and erythromycin base. The maximum concentration of drug in the serum, the half-life, and the area under the curve for erythromycin estolate were significantly greater than those of erythromycin ethylsuccinate after both regimens. After single and multiple doses, the respective areas under the curve of erythromycin base generated by estolate formulation were 3 and 1.6 times greater (P less than 0.05) than those of ethylsuccinate. The lower percentage of hydrolysis of erythromycin estolate (41 versus 69%) combined with its longer half-life (5.47 versus 2.72 h) and its larger area under the curve (30.61 versus 4.68 micrograms/h/ml, after multiple doses) could explain these differences. This study underscores the need for a specific high-pressure liquid chromatography assay and the importance of wide variability, rate-limited processes, changes with multiple doses, and the appearance of a second peak when one studies the pharmacokinetics of erythromycin esters. The pharmacokinetic data presented in this study reinforce the clinical advantages of erythromycin estolate over erythromycin ethylsuccinate.  (+info)

Amine content of vaginal fluid from untreated and treated patients with nonspecific vaginitis. (8/11)

We examined the vaginal washings from patients with nonspecific vaginitis (NSV) to seek biochemical markers and possible explanations for the signs and symptoms of this syndrome. Seven amines were identified including methylamine, isobutylamine, putrescine, cadaverine, histamine, tyramine, and phenethylamine. These amines may contribute to the symptoms of NSV and may contribute to the elevated pH of the vaginal discharge. They may also be partly responsible for the "fishy" odor that is characteristic of vaginal discharges from these patients. Among the seven amines, putrescine and cadaverine were the most abundant and were present in all vaginal discharges from each of ten patients before treatment. These amines are produced in vitro during growth of mixed vaginal bacteria in chemically defined medium, presumably by decarboxylation of the corresponding amino acids. We hypothesize the anaerobic vaginal organisms, previously shown to be quantitatively increased in NSV, are responsible for the amine production, because metronidazole inhibited the production of amines by vaginal bacteria in vitro, and Haemophilus vaginalis did not produce amines. H. vaginalis did release high concentrations of pyruvic acid and of amino acids during growth in peptone-starch-dextrose medium, whereas, other vaginal flora consumed both pyruvic acid and amino acids in the same medium during growth. These findings suggest that a symbiotic relationship may exist between H. vaginalis and other vaginal flora in patients with NSV.  (+info)

Erythromycin Estolate is an antibiotic medication, a salt of erythromycin, used to treat various bacterial infections and known for its potential to cause cholestatic hepatitis as a side effect.

Erythromycin Estolate is a type of antibiotic that belongs to the macrolide class. It is a formulation of erythromycin, an antibiotic produced naturally by the bacterium Saccharopolyspora erythraea, which is combined with estolic acid, a type of fatty acid, to create a stable salt. This medication works by inhibiting protein synthesis in bacteria, which helps to stop the growth and multiplication of harmful bacteria in the body.

Erythromycin Estolate is commonly used to treat a variety of bacterial infections, including respiratory tract infections, skin infections, and sexually transmitted diseases. It is also sometimes used as an alternative treatment for people who are allergic to penicillin or other antibiotics.

Like all medications, Erythromycin Estolate can have side effects, including stomach upset, diarrhea, and skin rashes. In rare cases, it may cause more serious side effects such as liver damage or hearing loss. It is important to follow the instructions of a healthcare provider when taking this medication and to report any unusual symptoms or side effects promptly.

Erythromycin Ethylsuccinate is a form of the antibiotic Erythromycin, where the active ingredient is combined with ethylsuccinate to improve its absorption and stability in the digestive system when administered orally.

Erythromycin Ethylsuccinate is a type of antibiotic that belongs to the macrolide class. It is a formulation of erythromycin, an antibiotic produced naturally by the bacterium Saccharopolyspora erythraea, which has been chemically modified by combining it with succinic acid and ethyl alcohol. This results in a more soluble and stable form of erythromycin that is better suited for oral administration.

Erythromycin Ethylsuccinate works by inhibiting bacterial protein synthesis, which prevents the bacteria from growing and multiplying. It is effective against a wide range of gram-positive and gram-negative bacteria, making it a useful antibiotic for treating various types of infections, such as respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases.

Like all antibiotics, Erythromycin Ethylsuccinate should be used only under the direction of a healthcare professional, as misuse can lead to antibiotic resistance and other complications. It is important to follow the dosage instructions carefully and complete the full course of treatment, even if symptoms improve before the medication is finished.

Erythromycin is a macrolide antibiotic medication, derived from the bacterium Saccharopolyspora erythraea, that inhibits protein synthesis by binding to the 50S subunit of the ribosome, used in the treatment of various bacterial infections including respiratory, skin, and soft tissue infections, as well as syphilis, chlamydia, and Legionnaires' disease.

Erythromycin is a type of antibiotic known as a macrolide, which is used to treat various types of bacterial infections. It works by inhibiting the bacteria's ability to produce proteins, which are necessary for the bacteria to survive and multiply. Erythromycin is often used to treat respiratory tract infections, skin infections, and sexually transmitted diseases. It may also be used to prevent endocarditis (inflammation of the lining of the heart) in people at risk of this condition.

Erythromycin is generally considered safe for most people, but it can cause side effects such as nausea, vomiting, and diarrhea. It may also interact with other medications, so it's important to tell your doctor about all the drugs you are taking before starting erythromycin.

Like all antibiotics, erythromycin should only be used to treat bacterial infections, as it is not effective against viral infections such as the common cold or flu. Overuse of antibiotics can lead to antibiotic resistance, which makes it harder to treat infections in the future.

"Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, typically described in terms of severity such as mild, moderate, severe or excruciating, and intensity, which may be acute or chronic." (Based on International Association for the Study of Pain definition)

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. It is a complex phenomenon that can result from various stimuli, such as thermal, mechanical, or chemical irritation, and it can be acute or chronic. The perception of pain involves the activation of specialized nerve cells called nociceptors, which transmit signals to the brain via the spinal cord. These signals are then processed in different regions of the brain, leading to the conscious experience of pain. It's important to note that pain is a highly individual and subjective experience, and its perception can vary widely among individuals.

"Pain management is a multidisciplinary medical approach aimed at reducing, eliminating or otherwise managing pain and improving quality of life through pharmacological, psychological, behavioral and interventional methods."

Pain management is a branch of medicine that focuses on the diagnosis and treatment of pain and improvement in the quality of life of patients with chronic pain. The goal of pain management is to reduce pain levels, improve physical functioning, and help patients cope mentally and emotionally with their pain. This may involve the use of medications, interventional procedures, physical therapy, psychological therapy, or a combination of these approaches.

The definition of pain management can vary depending on the medical context, but it generally refers to a multidisciplinary approach that addresses the complex interactions between biological, psychological, and social factors that contribute to the experience of pain. Pain management specialists may include physicians, nurses, physical therapists, psychologists, and other healthcare professionals who work together to provide comprehensive care for patients with chronic pain.

'Chronic pain' is defined as persistent, recurring pain lasting weeks or months, beyond the normal healing period, which significantly alters the individual's emotional and physical well-being, potentially leading to limitations in daily activities and impaired quality of life.

Chronic pain is defined as pain that persists or recurs for a period of 3 months or longer, beyond the normal healing time for an injury or illness. It can be continuous or intermittent and range from mild to severe. Chronic pain can have various causes, such as nerve damage, musculoskeletal conditions, or chronic diseases like cancer. It can significantly impact a person's quality of life, causing limitations in mobility, sleep disturbances, mood changes, and decreased overall well-being. Effective management of chronic pain often involves a multidisciplinary approach, including medications, physical therapy, psychological interventions, and complementary therapies.

"Pain measurement is the quantification of subjective pain experiences, typically through self-reported scales, behavioral observations, or physiological responses, to assess the intensity or unpleasantness of perceived harm or potential damage to an individual's tissues or bodily functions."

Pain measurement, in a medical context, refers to the quantification or evaluation of the intensity and/or unpleasantness of a patient's subjective pain experience. This is typically accomplished through the use of standardized self-report measures such as numerical rating scales (NRS), visual analog scales (VAS), or categorical scales (mild, moderate, severe). In some cases, physiological measures like heart rate, blood pressure, and facial expressions may also be used to supplement self-reported pain ratings. The goal of pain measurement is to help healthcare providers better understand the nature and severity of a patient's pain in order to develop an effective treatment plan.

Dentistry is the specialized branch of medicine that deals with the diagnosis, prevention, and treatment of diseases, disorders, and conditions of the oral cavity, maxillofacial region, and the adjacent structures, primarily focusing on the teeth and gums.

Dentistry is the branch of medicine that is concerned with the examination, diagnosis, prevention, and treatment of diseases, disorders, and conditions of the oral cavity (mouth), including the teeth, gums, and other supporting structures. Dentists use a variety of treatments and procedures to help patients maintain good oral health and prevent dental problems from developing or worsening. These may include:

* Routine cleanings and checkups to remove plaque and tartar and detect any potential issues early on
* Fillings, crowns, and other restorative treatments to repair damaged teeth
* Root canal therapy to treat infected or inflamed tooth pulp
* Extractions of severely decayed or impacted teeth
* Dentures, bridges, and implants to replace missing teeth
* Orthodontic treatment to align crooked or misaligned teeth
* Treatment for temporomandibular joint (TMJ) disorders and other issues affecting the jaw and surrounding muscles

Dental health is an important part of overall health and well-being. Poor oral health has been linked to a variety of systemic conditions, including heart disease, diabetes, and respiratory infections. Regular dental checkups and good oral hygiene practices can help prevent these and other dental problems from developing.

'Pain threshold' is the minimum level or intensity of a painful stimulus that an individual can reliably detect and recognize as painful, which varies between individuals and can be influenced by various factors including psychological, cultural, and physiological conditions.

Pain threshold is a term used in medicine and research to describe the point at which a stimulus begins to be perceived as painful. It is an individual's subjective response and can vary from person to person based on factors such as their pain tolerance, mood, expectations, and cultural background.

The pain threshold is typically determined through a series of tests where gradually increasing levels of stimuli are applied until the individual reports feeling pain. This is often used in research settings to study pain perception and analgesic efficacy. However, it's important to note that the pain threshold should not be confused with pain tolerance, which refers to the maximum level of pain a person can endure.

Postoperative pain is defined as tissue injury-related discomfort that occurs following a surgical procedure, which may be experienced at the incision site or in remote areas, and can vary in intensity and duration based on the type and extent of surgery, individual pain thresholds, and presence of any preexisting chronic pain conditions.

Postoperative pain is defined as the pain or discomfort experienced by patients following a surgical procedure. It can vary in intensity and duration depending on the type of surgery performed, individual pain tolerance, and other factors. The pain may be caused by tissue trauma, inflammation, or nerve damage resulting from the surgical intervention. Proper assessment and management of postoperative pain is essential to promote recovery, prevent complications, and improve patient satisfaction.

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Antibiotics1
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Treatment4
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Adverse effects2
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Stomach1
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Drugs1
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Drug2
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