A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
A macrolide antibiotic, produced by Streptomyces erythreus. It is the lauryl sulfate salt of the propionic ester of erythromycin. This erythromycin salt acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Substances that reduce the growth or reproduction of BACTERIA.
A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.
An antibiotic complex produced by Streptomyces kitasatoensis. The complex consists of a mixture of at least eight biologically active components, A1 and A3 to A9. Leucomycins have both antibacterial and antimycoplasmal activities.
An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A genus of gram-positive bacteria whose spores are round to oval and covered by a sheath.
An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections.
Compounds based on ERYTHROMYCIN with the 3-cladinose replaced by a ketone. They bind the 23S part of 70S bacterial RIBOSOMES.
A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER.
A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.
Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
Infections with bacteria of the genus STREPTOCOCCUS.
A macrolide antibiotic that has a wide antimicrobial spectrum and is particularly effective in respiratory and genital infections.
A cyclic polypeptide antibiotic complex from Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. It consists of 2 major components, VIRGINIAMYCIN FACTOR M1 and virginiamycin Factor S1. It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine, and poultry.
A family of LINCOMYCIN-related glycosides that contain a pyrrolidine ring linked via an amide-bond to a pyranose moiety. Individual members of this family are defined by the arrangement of specific constituent groups on the lyncomycin molecule. Many lincosamides are ANTIBIOTICS produced by a variety STREPTOMYCES species.
A peptide of about 22-amino acids isolated from the DUODENUM. At low pH it inhibits gastric motor activity, whereas at high pH it has a stimulating effect.
Antibiotic macrolide produced by Streptomyces antibioticus.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
A macrolide antibiotic that is similar to ERYTHROMYCIN.
A species of gram-negative, rod-shaped bacteria isolated from the intestinal tract of swine, poultry, and man. It may be pathogenic.
Nonsusceptibility of bacteria to the action of TETRACYCLINE which inhibits aminoacyl-tRNA binding to the 30S ribosomal subunit during protein synthesis.
The evacuation of food from the stomach into the duodenum.
Nonsusceptibility of an organism to the action of penicillins.
A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.
Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.
A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Proteins found in any species of bacterium.
Constituent of 50S subunit of prokaryotic ribosomes containing about 3200 nucleotides. 23S rRNA is involved in the initiation of polypeptide synthesis.
The functional hereditary units of BACTERIA.
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
A bacterium which causes mastitis in cattle and occasionally in man.
Gram-negative aerobic rods, isolated from surface water or thermally polluted lakes or streams. Member are pathogenic for man. Legionella pneumophila is the causative agent for LEGIONNAIRES' DISEASE.
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
A genus of bacteria found in the reproductive organs, intestinal tract, and oral cavity of animals and man. Some species are pathogenic.
Macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans.
A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.
Multicomponent ribonucleoprotein structures found in the CYTOPLASM of all cells, and in MITOCHONDRIA, and PLASTIDS. They function in PROTEIN BIOSYNTHESIS via GENETIC TRANSLATION.
Infections with bacteria of the genus STAPHYLOCOCCUS.
The motor activity of the GASTROINTESTINAL TRACT.
A species of gram-positive, coccoid bacteria commonly isolated from clinical specimens and the human intestinal tract. Most strains are nonhemolytic.
A species of bacteria that resemble small tightly coiled spirals. Its organisms are known to cause abortion in sheep and fever and enteritis in man and may be associated with enteric diseases of calves, lambs, and other animals.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
Inflammation of the throat (PHARYNX).
An acute, sometimes fatal, pneumonia-like bacterial infection characterized by high fever, malaise, muscle aches, respiratory disorders and headache. It is named for an outbreak at the 1976 Philadelphia convention of the American Legion.

Physiological role of the N-terminal processed P4501A1 targeted to mitochondria in erythromycin metabolism and reversal of erythromycin-mediated inhibition of mitochondrial protein synthesis. (1/2077)

Recently, we showed that the major species of beta-naphthoflavone-inducible rat liver mitochondrial P450MT2 consists of N-terminal truncated microsomal P4501A1 (+33/1A1) and that the truncated enzyme exhibits different substrate specificity as compared with intact P4501A1. The results of the present study show that P450MT2 targeted to COS cell mitochondria by transient transfection of P4501A1 cDNA is localized inside the mitochondrial inner membrane in a membrane-extrinsic orientation. Co-expression with wild type P4501A1 and adrenodoxin (Adx) cDNAs resulted in 5-7-fold higher erythromycin N-demethylation (ERND) in the mitochondrial fraction but minimal changes in the microsomal fraction of transfected cells. Erythromycin, a potent inhibitor of bacterial and mitochondrial protein synthesis, caused 8-12-fold higher accumulation of CYP1A1 mRNA, preferential accumulation of P450MT2, and 5-6-fold higher ERND activity in the mitochondrial compartment of rat C6 glioma cells. Consistent with the increased mitochondrial ERND activity, co-expression with P4501A1 and Adx in COS cells rendered complete protection against erythromycin-mediated mitochondrial translation inhibition. Mutations that specifically affect the mitochondrial targeting of P4501A1 also abolished protection against mitochondrial translation inhibition. These results for the first time suggest a physiological function for the xenobiotic inducible cytochrome P4501A1 against drug-mediated mitochondrial toxicity.  (+info)

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. (2/2077)

The structures of complex polyketide natural products, such as erythromycin, are programmed by multifunctional polyketide synthases (PKSs) that contain modular arrangements of functional domains. The colinearity between the activities of modular PKS domains and structure of the polyketide product portends the generation of novel organic compounds-"unnatural" natural products-by genetic manipulation. We have engineered the erythromycin polyketide synthase genes to effect combinatorial alterations of catalytic activities in the biosynthetic pathway, generating a library of >50 macrolides that would be impractical to produce by chemical methods. The library includes examples of analogs with one, two, and three altered carbon centers of the polyketide products. The manipulation of multiple biosynthetic steps in a PKS is an important milestone toward the goal of producing large libraries of unnatural natural products for biological and pharmaceutical applications.  (+info)

Increased activity of 16-membered lactone ring macrolides against erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae: characterization of South African isolates. (3/2077)

The susceptibility of 40 erythromycin-resistant isolates of Streptococcus pyogenes and 40 multiply-resistant isolates of Streptococcus pneumoniae to six macrolide antibiotics, representing 14-, 15- and 16-membered lactone ring structures, was tested. The genetic basis for macrolide resistance in the strains was also determined. Both erm and mef determinants were encountered in the 36 S. pneumoniae isolates tested, but only mef in the five S. pyogenes isolates tested. All isolates showed cross-resistance among the 14-membered macrolides erythromycin, clarithromycin and roxithromycin and the 15-membered macrolide, azithromycin. However, the erythromycin-resistant S. pyogenes isolates retained full susceptibility to spiramycin and josamycin (16-membered agents). These latter two antibiotics were also more active than the other macrolides against erythromycin-resistant S. pneumoniae isolates, especially josamycin which was 8-64 times more active than erythromycin; spiramycin was only two to eight times more active than erythromycin.  (+info)

A pilot study of low-dose erythromycin in bronchiectasis. (4/2077)

Patients with bronchiectasis suffer from sputum production, recurrent exacerbations, and progressive airway destruction. Erythromycin is effective in diffuse panbronchiolitis, another suppurative airway disorder, although its efficacy is unknown in idiopathic bronchiectasis. A double-blind placebo-controlled study was therefore conducted to evaluate the effects of 8-week administration of low dose erythromycin (500 mg b.i.d.) in steady-state idiopathic bronchiectasis. Patients in the erythromycin group (n=11, 8 female, mean age 50+/-15 yrs), but not the placebo group (n=10, 8 female, mean age 59+/-16 yrs) had significantly improved forced expiratory volume in one second, forced vital capacity and 24-h sputum volume after 8 weeks (p<0.05). There was no parallel improvement in sputum pathogens, leukocytes, interleukin (IL)-1alpha and IL-8, tumour necrosis factor-alpha, or leukotriene B4. The results of this pilot study show that low-dose erythromycin improves lung function and sputum volume in bronchiectasis. Further studies are indicated to evaluate the efficacy of long-term erythromycin therapy in bronchiectasis.  (+info)

Extremely high incidence of macrolide and trimethoprim-sulfamethoxazole resistance among clinical isolates of Streptococcus pneumoniae in Taiwan. (5/2077)

From January 1996 to December 1997, 200 isolates of Streptococcus pneumoniae recovered from 200 patients treated at National Taiwan University Hospital were serotyped and their susceptibilities to 16 antimicrobial agents were determined by the agar dilution method. Sixty-one percent of the isolates were nonsusceptible to penicillin, exhibiting either intermediate resistance (28%) or high-level resistance (33%). About two-fifths of the isolates displayed intermediate or high-level resistance to cefotaxime, ceftriaxone, cefepime, imipenem, and meropenem. Extremely high proportions of the isolates were resistant to erythromycin (82%), clarithromycin (90%), and trimethoprim-sulfamethoxazole (TMP-SMZ) (87%). Among the isolates nonsusceptible to penicillin, 23.8% were resistant to imipenem; more than 60% displayed resistance to cefotaxime, ceftriaxone, cefepime, and carbapenems; 96.7% were resistant to erythromycin; and 100% were resistant to TMP-SMZ. All isolates were susceptible to rifampin and vancomycin. The MICs at which 50% and 90% of the isolates were inhibited were 0.12 and 1 microgram/ml, respectively, for cefpirome, and 0.12 and 0.25 microgram/ml, respectively, for moxifloxacin. Six serogroups or serotypes (23F, 19F, 6B, 14, 3, and 9) accounted for 77.5% of all isolates. Overall, 92.5% of the isolates were included in the serogroups or serotypes represented in the 23-valent pneumococcal vaccine. The incidence of macrolide and TMP-SMZ resistance for S. pneumoniae isolates in Taiwan in this study is among the highest in the world published to date.  (+info)

Erythromycin enhances early postoperative contractility of the denervated whole stomach as an esophageal substitute. (6/2077)

OBJECTIVE: To determine whether early postoperative administration of erythromycin accelerates the spontaneous motor recovery process after elevation of the denervated whole stomach up to the neck. SUMMARY BACKGROUND DATA: Spontaneous motor recovery after gastric denervation is a slow process that progressively takes place over years. METHODS: Erythromycin was administered as follows: continuous intravenous (i.v.) perfusion until postoperative day 10 in ten whole stomach (WS) patients at a dose of either 1 g (n = 5) or 2 g (n = 5) per day; oral intake at a dose of 1 g/day during 1.5 to 8 months after surgery in 11 WS patients, followed in 7 of them by discontinuation of the drug during 2 to 4 weeks. Gastric motility was assessed with intraluminal perfused catheters in these 21 patients, in 23 WS patients not receiving erythromycin, and in 11 healthy volunteers. A motility index was established by dividing the sum of the areas under the curves of >9 mmHg contractions by the time of recording. RESULTS: The motility index after IV or oral administration of erythromycin at and after surgery was significantly higher than that without erythromycin (i.v., 1 g: p = 0.0090; i.v., 2 g: p = 0.0090; oral, 1 g: p = 0.0017). It was similar to that in healthy volunteers (i.v., 1 g: p = 0.2818; oral, 1 g: p = 0.7179) and to that in WS patients with >3 years of follow-up who never received erythromycin (i.v., 1 g: p = 0.2206; oral, 1 g: p = 0.8326). The motility index after discontinuation of the drug was similar or superior to that recorded under medication in four patients who did not experience any modification of their alimentary comfort, whereas it dropped dramatically parallel to deterioration of the alimentary comfort in three patients. CONCLUSIONS: Early postoperative contractility of the denervated whole stomach pulled up to the neck under either i.v. or oral erythromycin is similar to that recovered spontaneously beyond 3 years of follow-up. In some patients, this booster effect persists after discontinuation of the drug.  (+info)

Effect of cyclosporine A on cytochrome P-450-mediated drug metabolism in the partially hepatectomized rat. (7/2077)

Despite its hepatotoxic potential, cyclosporine A (CsA) has been reported to positively influence compensatory liver growth. To probe the physiological consequences of CsA on the recovery of liver function, studies were initiated in the 2/3 partially hepatectomized (PHx) rat, taking the recovery of cytochromes P-450-dependent drug metabolism as primary outcome. CsA was administered at a dose of 3. 33 mg/kg/day for 10 days. Drug metabolism was evaluated by the recovery of 14CO2 after administration of isotopically labeled model drugs and by studying the expression of the P-450 transcripts involved in their biotransformation before and 24 to 96 h after PHx. Before PHx, neither the steady-state mRNA nor the in vivo disposition of caffeine (CYP1A2), erythromycin (CYP3A2 and 3A1), or aminopyrine (CYP2B1 and 2C11) were influenced by CsA. Studies 24 h after PHx revealed a 29 to 39% reduction in the elimination of [14C]aminopyrine and [14C]erythromycin, which was unaffected by CsA. Their metabolism at 48 to 96 h after PHx also remained unaffected by CsA. By contrast, postPHx, [14C]caffeine elimination decreased to a level closely proportional to the loss in liver mass. In addition, CsA accelerated the recovery and/or prevented the decrease of caffeine elimination 24 h after PHx but not at later time points, indicating an early, but unsustained, beneficial effect of CsA on the recovery of CYP1A2-mediated activities. These data show that at the critical time of greatest loss in liver mass, CsA has only a selective influence on the biotransformation of cytochrome P-450 protein-dependent activities and that its effect on the regeneration process does not translate into an overall accelerated recovery of the hepatic drug-metabolizing function.  (+info)

Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors. (8/2077)

Macrolide antibiotics such as erythromycin have been reported to be effective for asthma. However, the precise mechanisms of this effect remain unclear. We studied the effect of erythromycin, clarithromycin, josamycin, and other antibiotics on the release by eosinophils of interleukin-8 (IL-8), a potent chemokine for inflammatory cells, including eosinophils themselves. Human eosinophils were isolated from atopic patients, and the effects of the drugs on IL-8 release were evaluated. Only 14-member macrolides (erythromycin and clarithromycin) showed a concentration-dependent suppressive effect on IL-8 release (control, 100%; erythromycin at 1 microgram/ml, 67.82% +/- 3.45% [P < 0.01]; clarithromycin at 5 micrograms/ml, 56.81% +/- 9.61% [P < 0.01]). The effect was found at therapeutic concentrations and appeared to occur at the posttranscriprtional level. In contrast, a 16-member macrolide (josamycin) had no significant effect. We suggest that 14-member macrolides inhibit IL-8 release by eosinophils and may thereby prevent the autocrine cycle necessary for the recruitment of these cells into the airways.  (+info)

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TY - JOUR. T1 - Plasma erythromycin concentrations predict feeding outcomes in critically ill patients with feed intolerance. AU - Nguyen, N. Q.. AU - Grgurinovich, N. G.. AU - Bryant, L. K.. AU - Chapman, M. J.. AU - Holloway, R. H.. AU - Mangoni, A. A.. AU - Fraser, R. J.. PY - 2011/4. Y1 - 2011/4. N2 - Objective: Motilin receptors are rapidly down-regulated by exposure to erythromycin, and its progressive loss of clinical prokinetic effect may relate to higher plasma drug concentrations. This study aimed to evaluate the relationship between plasma erythromycin concentrations and feeding outcomes in critically ill patients.Design: Observational comparative study.Setting: Tertiary critical care unit.Patients: Twenty-nine feed-intolerant (gastric residual volume ,250 mL) mechanically ventilated, medical critically ill patients.Interventions: Patients received intravenous erythromycin 200 mg twice daily for feed intolerance.Measurements: Plasma erythromycin concentrations were measured 1 and 7 ...
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Our results indicate that VLBW infants with feed intolerance due to non-anatomically obstructive gastrointestinal dysmotility achieved full enteral feeding significantly earlier after treatment with oral erythromycin. The median times taken to establish half, three quarters, and full enteral nutrition were 3.5, 8.5, and 13.5 days after the start of oral erythromycin. The median times taken to achieve half and full oral feeding in the placebo group were almost twice as long (table2). These findings agree with those of previous case series in preterm infants.13-15 Although a recent randomised controlled study did not show any benefit of intravenous erythromycin in improving the tolerance of enteral feeding in preterm infants,25these findings were not entirely unexpected because the study was not primarily designed to investigate the effectiveness of erythromycin on enteral feeding, but rather focused on the relation between chronic lung disease and intravenous erythromycin treatment for ...
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The genes for ribosomal proteins L4 and L22 from two erythromycin-resistant mutants of Escherichia coli have been isolated and sequenced. In the L4 mutant, an A-to-G transition in codon 63 predicted a Lys-to-Glu change in the protein. In the L22 strain, a 9-bp deletion removed codons 82 to 84, eliminating the sequence Met-Lys-Arg from the protein. Consistent with these DNA changes, in comparison with wild-type proteins, both mutant proteins had reduced first-dimension mobilities in two-dimensional polyacrylamide gels. Complementation of each mutation by a wild-type gene on a plasmid vector resulted in increased erythromycin sensitivity in the partial-diploid strains. The fraction of ribosomes containing the mutant form of the protein was increased by growth in the presence of erythromycin. Erythromycin binding was increased by the fraction of wild-type protein present in the ribosome population. The strain with the L4 mutation was found to be cold sensitive for growth at 20 degrees C, and ...
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Erythromycin combines the antimicrobial effect and prokinetic properties in Hepatic encephalopathy Liver cirrhosis Erythromycin Neomycin. Cholestasis is a condition where bile cannot flow from the liver to the duodenum. The two basic cholangitis, associated with inflammatory bowel disease; some drugs (e.g.. flucloxacillin and erythromycin) cimetidine, erythromycin, estrogen, and statins can cause cholestasis and may result in damage to the liver. Prescribing should be carefully done in all patients with severe liver disease. The main problems They include macrolides like erythromycin, azithro- mycin. The following antibiotics belong to this family: Erythromycin, Some of these antibiiotics can actually put us into liver failure.. i carry a list in my. Of erythromycin that contains a methoxy substitution at. C-6 of the erythronolide ring (6-0-methylerythromycin). Mild reversible liver injury, predominantly. Clinical manifestations of erythromycin estolate- induced liver disease were severe ...
The current study confirms our earlier findings that erythromycin administered intravenously in healthy volunteers has a dose related effect on the interdigestive motility of the stomach and the small intestine.3 A low dose (40 mg) of erythromycin induced a premature activity front at the antral level which migrated through the small intestine. A higher dose of erythromycin (200 mg) induced strong and prolonged antral contractile activity which was not propagated to the small intestine. The effect of a single dose of atropine or sumatriptan was used to investigate the effect of both treatments on the antral motor effects of two different doses of erythromycin. Prior administration of the muscarinic antagonist atropine blocked the generation of a premature activity front in the stomach by a low dose of erythromycin. However, prolonged antral contractile activity induced by a high dose of erythromycin remained unaffected by atropine. Similar findings were observed after administration of the ...
BioAssay record AID 369229 submitted by ChEMBL: Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent resistant isolates by CLSI breakpoint method.
TY - JOUR. T1 - Determination of erythromycin concentrations in rat plasma and liver by high-performance liquid chromatography with amperometric detection. AU - Hanada, Erika. AU - Ohtani, Hisakazu. AU - Kotaki, Hajime. AU - Sawada, Yasufumi. AU - Iga, Tatsuji. PY - 1997/5/9. Y1 - 1997/5/9. N2 - A simple method for the quantitative determination of erythromycin (EM) concentrations in rat plasma and liver by high-performance liquid chromatography with amperometric detection was developed. EM was extracted from 200 μl of plasma or liver homogenate sample under sodium hydroxide alkaline conditions with tert.-butyl methyl ether. Oleandomycin was used as an internal standard. The recovery rate of EM was up to 100%. The detector cell potential for the oxidation of EM was +1100 mV. The calibration curves were linear over the concentration ranges 0.1-20.0 μg/ml for plasma and 0.5-100.0 μg/g for liver. The method was applied to the determination of the plasma and liver concentrations of EM in rats ...
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Apr 03, 2020 · Erythromycin is an antibiotic that fights bacteria. Apply a 1-2cm ribbon of ointment to the lower conjunctival sac of each eye: the medicines may also be used in drop form. Erythromycin topical (for the skin) is used to treat acne vulgaris in adults. 1. erythromycin [ĕ-rith″ro-mi´sin] a broad-spectrum antibiotic produced by a strain of Streptomyces erythreus, administered orally, parenterally, and topically to the skin or to the eye, and effective against a wide variety of organisms, including gram-negative and gram-positive bacteria. One of the most common uses of erythromycin ointment is to prevent neonatal conjunctivitis, an eye infection in newborns 1 3.According to the University of Hawaiis School of Medicine, between 2 to 12 percent of newborns have eye infections 2.In many infants, the condition often results from the erythromycin what is it used for birth canal, particularly if the mother has herpes or gonorrhea Dec 03, 2019 · Erythromycin 500 MG Tablet, a macrolide ...
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OBJECTIVES: To test four 16-membered macrolides (josamycin, spiramycin, midecamycin and rokitamycin) along with other compounds in the same class (erythromycin, clarithromycin, roxithromycin and azithromycin) plus clindamycin and telithromycin, against Streptococcus pyogenes and Streptococcus pneumoniae isolates with well-characterized resistance genotypes. METHODS: Four hundred and eighty-six isolates of S. pyogenes and 375 isolates of S. pneumoniae were assayed for their macrolide susceptibilities and investigated by PCR to detect their different erythromycin resistance genes. All strains had been isolated over the period 2002-2003 from specimens of different human origin obtained in 14 different Italian centres. RESULTS: All 16-membered macrolides showed very low MICs (MIC(50)s and MIC(90)s, , or =0.06-0.5 mg/L) for the erythromycin-susceptible isolates and for those with the M phenotype, but the telithromycin MICs for the M-type isolates were at least four times higher (MIC(90)s, 0.5 mg/L). ...
This study evaluated the chronic impact of erythromycin, a macrolide antibiotic, on microbial activities, mainly focusing on changes in process kinetics induced on substrate biodegradation and all related biochemical processes of microbial metabolism. Experiments involved two fill/draw reactors sustained at steady state at two different sludge ages of 10 and 2.0 days, fed with peptone mixture and continuous erythromycin dosing of 50 mg/L. Oxygen uptake rate profiles were generated in a series of parallel batch reactors seeded with biomass from fill/draw systems at selected periods of steady-state operation. Experimental data were evaluated by model calibration reflecting inhibitory effect on process kinetics: continuous erythromycin dosing inhibited microbial growth, reduced the rate of hydrolysis, blocked substrate storage and accelerated endogenous respiration. Adverse impact was mainly due to changes inflicted on the composition of microbial community. Interruption of erythromycin feeding ...
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"ERYTHROMYCIN". Br Med J. 2 (4793): 1085-6. November 1952. doi:10.1136/bmj.2.4793.1085. PMC 2022076. PMID 12987755. Anderson, ... erythromycin (discovered at Eli Lilly and Co.) and their extension to an increasingly wide range of bacterial pathogens. ...
Erythromycin-based medications can also be used. A single study suggests superiority of azithromycin over doxycycline. Another ... "Erythromycin" (PDF). Davis. 2017. Archived from the original (PDF) on 2017-09-10. Retrieved March 24, 2017. "Pelvic ...
Erythromycin, an antibiotic. Aflatoxin B1 one of the most carcinogenic compounds known. Polyketides are produced in bacteria, ... The antibiotics erythromycin A, clarithromycin, and azithromycin The antihelminthics avermectin and ivermectin The insecticide ...
Erythromycin is similar. 4.8% tranexamic acid solution is sometimes used as an antifibrinolytic mouthwash to prevent bleeding ...
... erythromycin precursor synthase) show only a 45% common identity. Note that unlike in the erythromycin precursor synthase, ... However, unlike erythromycin and its effective synthetic derivatives, it lacks a 12-hydroxyl group and a 3-methoxy group. This ... Like erythromycin, oleandomycin binds to the 50s subunit of bacterial ribosomes, inhibiting the completion of proteins vital to ... It is weaker than erythromycin. It used to be sold under the brand name Sigmamycine, combined with tetracycline, and made by ...
Erythromycin may be an alternative. For use in combination regimens for eradication of H. pylori in adults Imipenem/cilastatin ... vaccine Atracurium Neostigmine Suxamethonium Vecuronium Pyridostigmineα Vecuroniumα Aciclovir Azithromycin Erythromycin ...
Weisblum, B (March 1995). "Erythromycin resistance by ribosome modification". Antimicrobial Agents and Chemotherapy. 39 (3): ... or erythromycin ribosome methylase family of genes. Nearly 40 erm genes have been reported to date, which are transferred ...
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These include tetracycline, doxycycline, and erythromycin. Erythromycin may be used as a cream. Doxycycline is most often the ...
The first macrolide discovered was erythromycin, which was first used in 1952. Erythromycin was widely used as a substitute to ... Macrolides, mainly erythromycin and clarithromycin, also have a class effect of QT prolongation, which can lead to torsades de ... The macrolide antibiotics erythromycin, clarithromycin, and roxithromycin have proven to be an effective long-term treatment ... In infants the use of erythromycin has been associated with pyloric stenosis. Some macrolides are also known to cause ...
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... erythromycin Mycoplasma pneumoniae - erythromycin Coxiella burnetti - doxycycline Legionella pneumophila - erythromycin, with ... Streptococcus pneumoniae - amoxicillin (or erythromycin in patients allergic to penicillin); cefuroxime and erythromycin in ...
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Use of 1% tetracycline ointment or 0.5% erythromycin ointment or 1% silver nitrate solution (Crede's method) into the eyes of ... Neonatal inclusion conjunctivitis caused by Chlamydia trachomatis should be treated with oral erythromycin. Topical therapy is ... "Topical sulfacetamide vs oral erythromycin for neonatal chlamydial conjunctivitis." American Journal of diseases of children ... Infants with chlamydia pneumonitis should be treated with oral erythromycin for 10-14 days.[6] ...
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Unlike erythromycin, telithromycin is acid-stable and can therefore be taken orally while being protected from gastric acids. ... Telithromycin is a semi-synthetic erythromycin derivative. It is created by substituting a ketogroup for the cladinose sugar ... Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, telithromycin strongly bind ...
... produces nonactin, erythromycin and werramycine. List of Streptomyces species LPSN bacterio.net ... "Isolation and partial purification of erythromycin from alkaliphilic Streptomyces werraensis isolated from Rajkot, India". ... "Isolation and partial purification of erythromycin from alkaliphilic Streptomyces werraensis isolated from Rajkot, India". ...
Schachner, L.; Eaglstein, W.; Kittles, C.; Mertz, P. (1990). "Topical erythromycin and zinc therapy for acne". Journal of the ... or combined with an antibiotic such as erythromycin for the topical treatment of acne. It is commonly sold as a topical anti- ...
In case of legionellosis, erythromycin or fluoroquinolone. A third generation cephalosporin (ceftazidime) + carbapenems ( ...
Apr 2010). "Erythromycin as a prokinetic agent: risk factors". Journal of Visceral Surgery. 147 (2): e13-8. doi:10.1016/j. ... Other molecules, including macrolides such as mitemcinal and erythromycin, have affinity for the motilin receptor where they ...
Drugs that decrease the metabolism of carbamazepine or otherwise increase its levels include erythromycin, cimetidine, ... "Erythromycin-induced carbamazepine toxicity: a continuing problem". Archives of Pediatrics & Adolescent Medicine. 149 (1): 99- ...
Cupp-Vickery, JR; Poulos, TL (February 1995). "Structure of cytochrome P450eryF involved in erythromycin biosynthesis". Nature ... Saccharopolyspora erythraea produces the macrolide antibiotic erythromycin. Cytochrome P450 eryF (CYP107A1) originally from the ... "Complete genome sequence of the erythromycin-producing bacterium : Saccharopolyspora erythraea: NRRL23338". Nature ...
Weber JM, Leung JO, Swanson SJ, Idler KB, McAlpine JB (April 1991). "An erythromycin derivative produced by targeted gene ... Cupp-Vickery JR, Poulos TL (February 1995). "Structure of cytochrome P450eryF involved in erythromycin biosynthesis". Nature ... which is the first step of biosynthesis of the macrolide antibiotic erythromycin. This bacterial enzyme belongs to CYP family ...
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Erythromycin: This is a wide spectrum antibiotic that has a similar range on the antibacterial spectrum to penicillin, making ... Erythromycin, clindamycin and metronidazole are antibiotics that would require dose adjustments when administered to patients ... Therefore, in the cases of allergies, erythromycin is used instead. Antibiotics should only be used for oral infections where ... Alternative antibiotics include Erythromycin, cephalosporin and several others. Tetracycline: A wide spectrum antibiotic used ...
... interacts with the antibiotic erythromycin, a strong inhibitor of CYP3A4, which affects concentration peak time. ... Luurila H, Olkkola KT, Neuvonen PJ (April 1995). "Interaction between erythromycin and nitrazepam in healthy volunteers". ... Coadministration of benzodiazepine drugs at therapeutic doses with erythromycin may cause serious psychotic symptoms, ... Following administration of nitrazepam, triazolam, and subsequently erythromycin, the patient experienced repetitive ...
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erythromycin is a Conjugate Acid of. erythromycin cation Definition : An organic cation obtained by protonation of any ... CHEBI:48923 - erythromycin. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .bx-loading { display: none ...
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  • Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin , and is often used for people who have an allergy to penicillins. (princeton.edu)
  • Erythromycin is a type of medicine known as a macrolide antibiotic. (netdoctor.co.uk)
  • Erythromycin is a broad-spectrum antibiotic that is active against a wide variety of bacteria that cause a wide variety of infections. (netdoctor.co.uk)
  • Erythromycin (0.5%) ophthalmic ointment is the only antibiotic ointment currently recommended and the only drug cleared by the FDA for the prophylaxis of gonococcal ophthalmia neonatorum. (cdc.gov)
  • Erythromycin is a macrolide antibiotic . (sourcewatch.org)
  • Erythromycin is an antibiotic produced from a strain of Streptomyces erythraeus. (news-medical.net)
  • Stiemycin alcoholic solution contains the active ingredient erythromycin, which is a type of medicine known as a macrolide antibiotic. (netdoctor.co.uk)
  • ERYTHROMYCIN (er ith roe MYE sin) is a macrolide antibiotic. (nationwidechildrens.org)
  • Erythromycin is a macrolide antibiotic produced from a strain of the actinomycete Saccharopolyspora erythraea , formerly known as Streptomyces erythraeus . (newworldencyclopedia.org)
  • Erythromycin is an antibiotic that fights bacteria. (rexhealth.com)
  • Erythromycin is an antibiotic used for the treatment of a number of bacterial infections . (wikipedia.org)
  • Erythromycin is a primarily gram positive antibiotic with a slightly 'wider' antimicrobial spectrum to otherwise similar to penicillin. (liberalconspiracy.org)
  • Fish Mycin™ (Erythromycin) from Thomas Labs is an antibiotic that exerts a bactericidal action on gram-positive and some gram-negative bacteria in fish. (liberalconspiracy.org)
  • Erythromycin is a macrolide antibiotic, and it is active principally against gram-positive cocci and bacilli, as well as-to a lesser extent-gram-negative cocci and bacilli. (uspharmacist.com)
  • Erythromycin is an wide-spectrum antibiotic that is used in ophthalmic, topical, and systemic treatment of bacterial infections. (fsu.edu)
  • Erythromycin ophthalmic ointment is an antibiotic cream applied to the eye to treat eye infections. (wisegeek.com)
  • A macrolide antibiotic, erythromycin is derived from the actinomycete Saccharopolyspora erythraea genus. (wisegeek.com)
  • Erythromycin is a bacteriostatic antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics which consists of Azithromycin , Clarithromycin , Spiramycin and others. (drugbank.ca)
  • Erythromycin is an antibiotic. (cigna.com)
  • There are no specific warnings about drinking alcohol while taking erythromycin, but there's some evidence that alcohol might result in delayed absorption of the antibiotic. (everydayhealth.com)
  • Scientists at Chugai Pharmaceuticals discovered an erythromycin-derived motilin agonist called Mitemcinal that is believed to have strong prokinetic properties (similar to erythromycin,) but lacking antibiotic properties. (thefullwiki.org)
  • Erythromycin topical is an antibiotic that fights skin infection caused by bacteria. (wellspan.org)
  • Erythromycin is a macrolide antibiotic produced by Saccharopolyspora erythraea . (sgs.com)
  • As the result of increasing awareness of food safety among consumers with respect to antimicrobial resistance, maximum residue limits (MRLs) for erythromycin in foods have been established by international bodies and organizations including the European Union (EU), Heath Canada, and Codex in order to control antibiotic abuse. (sgs.com)
  • Erythromycin is a macrolide antibiotic that fights bacteria in the body. (emedicinehealth.com)
  • Preterm Premature Rupture of Membranes (PPROM) is treated with an antibiotic, erythromycin or azithromycin, to prolong pregnancy. (clinicaltrials.gov)
  • The goal of this study is to see if there is a difference between the antibiotic (azithromycin) compared to the antibiotic ( erythromycin ) in prolonging pregnancy in patients with Preterm Premature Rupture of Membranes (PPROM). (clinicaltrials.gov)
  • The working hypothesis is that there is no difference in the clinical effectiveness between antibiotic regimens containing the macrolides azithromycin and erythromycin for prolonging latency in PPROM. (clinicaltrials.gov)
  • It contains the active ingredient erythromycin, which is a type of medicine known as a macrolide antibiotic. (dokteronline.com)
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  • Bacterial cells control resistance to the macrolide antibiotic erythromycin using the MphR(A) repressor protein . (rsc.org)
  • Erythromycin is an antibiotic that has an effect on the gastrointestinal tract and may help infants with feeding problems. (cochrane.org)
  • Molecular model of human cytochrome P450 complexed with the antibiotic erythromycin. (sciencephoto.com)
  • It was first marketed by Eli Lilly and Company , and it is today commonly known as EES (erythromycin ethylsuccinate, an ester prodrug that is commonly administered). (princeton.edu)
  • However, long-term (2-year) oral studies in rats with erythromycin ethylsuccinate and erythromycin base did not provide evidence of tumorigenicity. (rxlist.com)
  • In the treatment of streptococcal infections, a therapeutic dosage of erythromycin ethylsuccinate should be administered for at least 10 days. (liberalconspiracy.org)
  • For oral erythromycin (not erythromycin ethylsuccinate) products, the standard adult dosage ranges from 250 mg to 500 mg every 6 to 12 hours, depending on the particular infection and the product being used. (liberalconspiracy.org)
  • Erythromycin Ethylsuccinate EP 250 mg/5 ml (where each mg of base is taken to be equivalent to 1000 units of activity) Excipients with known effect. (liberalconspiracy.org)
  • Ca/documents/drug-shortages/Erythromycin Erythromycin Suspension All Erythromycin suspensions are currently unavailable with Erythromycin content is listed as the equivalent of the base thus erythromycin ethylsuccinate 400 mg is equivalent to erythromycin base 400mg. (liberalconspiracy.org)
  • COMPOSITION: Each 5 mL of the reconstituted suspension contains: (1) Erythromycin ethylsuccinate equivalent to 125 mg erythromycin base (2) Best Pills Worst Pills Lexapro Erythromycin ethylsuccinate equivalent to 250 mg erythromycin base. (liberalconspiracy.org)
  • The Food and Drug Administration (FDA) released a report of an erythromycin (0.5%) ophthalmic ointment shortage on March 5, 2019. (cdc.gov)
  • If erythromycin ointment is not available, CDC recommends that neonates at risk for exposure to N. gonorrhoeae during delivery (especially those born to a mother at risk for gonococcal infection or with no prenatal care) be administered ceftriaxone 25-50 mg/kg IV or IM, not to exceed 125 mg in a single dose. (cdc.gov)
  • Current information regarding the availability of erythromycin (0.5%) ophthalmic ointment is available at the FDA Drug Shortage Website External . (cdc.gov)
  • Ophthalmic erythromycin comes as an ointment to apply to the eyes. (medlineplus.gov)
  • Use erythromycin eye ointment exactly as directed. (medlineplus.gov)
  • Erythromycin eye ointment may cause side effects. (medlineplus.gov)
  • After using erythromycin eye ointment, wipe the tip of the ointment tube with a clean tissue and keep the tube tightly closed. (mayoclinic.org)
  • what is Erythromycin Ophthalmic Ointment? (wisegeek.com)
  • Erythromycin ophthalmic ointment can be used to treat conjunctivitis. (wisegeek.com)
  • In addition to the treatment of bacterial infections, erythromycin ophthalmic ointment is a preventative treatment for infants for neisseria gonorrhoeae or chlamydia trachomatis at birth. (wisegeek.com)
  • Incidence of opthalmia in newborns has been found to decrease dramatically after a regimen of erythromycin ophthalmic ointment. (wisegeek.com)
  • Erythromycin ophthalmic ointment can be used to prevent bacterial infections in the eyes of newborns. (wisegeek.com)
  • Common side effects of erythromycin ophthalmic ointment are mild and might include irritation, itching, redness, excessive tearing and light sensitivity. (wisegeek.com)
  • Erythromycin ophthalmic ointment is only available by prescription. (wisegeek.com)
  • What do you treat with erythromycin ophthalmic ointment? (reference.com)
  • It is important to closely adhere to the instructions on the prescription label when using erythromycin ophthalmic ointment. (reference.com)
  • Side effects from erythromycin ophthalmic ointment include burning of the eye, stinging, itching and redness. (reference.com)
  • A formulation for preparing Erythromycin 1% and Neomycin Sulfate Ointment. (ijpc.com)
  • Erythromycin ointment is fine to use, and is used the same a terramycin ointment for respiratory diseases or conjunctivitis (pinkeye. (backyardchickens.com)
  • Wife has a prosthetic eye so we always have Erythromycin ointment on hand. (backyardchickens.com)
  • [5] Erythromycin is available in the strengths 250mg and 500mg. (sourcewatch.org)
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  • The protocol will enroll 250 eligible women who will then be randomized to receive either azithromycin 1 gm orally at enrollment or erythromycin 250mg IV every 6 hours for 48 hours followed by 500mg orally every 8hours for 5 days. (clinicaltrials.gov)
  • Erythromycin doesn't directly kill the bacteria, but leaves them unable to increase in numbers. (netdoctor.co.uk)
  • To make sure the bacteria causing an infection are susceptible to erythromycin your doctor may take a tissue sample, for example a swab from the throat or skin. (netdoctor.co.uk)
  • Erythromycin is also active against the bacteria associated with acne, Propionebacterium acnes . (netdoctor.co.uk)
  • If you stop using ophthalmic erythromycin too soon, your infection may not be completely cured and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • Erythromycin is used to treat infections caused by bacteria. (netdoctor.co.uk)
  • The erythromycin works by attacking the bacteria associated with acne, Propionibacterium acnes. (netdoctor.co.uk)
  • Erythromycin prevens these bacteria from producing proteins that are essential to them. (netdoctor.co.uk)
  • Erythromycins are prescribed for a wide variety of infections caused by bacteria , including pneumonia, strep throat , bronchitis , ear infections, urinary tract infections, and tonsillitis (Ross-Flanigan 2004). (newworldencyclopedia.org)
  • Erythromycin represents one of the many helpful drugs derived from nature-in this case, a drug used to kill or impede the growth of bacteria that actually is derived from a bacterial strain itself. (newworldencyclopedia.org)
  • Clindamycin are more effective than erythromycin for treatment of infections caused by anaerobic bacteria (ones that grow in the absence of oxygen) (Ross-Flanigan and Uretsky 2005). (newworldencyclopedia.org)
  • Erythromycin was first isolated in 1952 from the bacteria Saccharopolyspora erythraea . (wikipedia.org)
  • Erythromycin can be used to treat bacteria responsible for causing infections of the skin and upper respiratory tract, including Streptococcus , Staphylococcus , Haemophilus and Corynebacterium genera. (wikipedia.org)
  • 20 Erythromycin is widely used for treating a variety of infections, including those caused by gram-positive and gram-negative bacteria. (drugbank.ca)
  • Erythromycin topical prevents bacteria from growing on the skin. (cigna.com)
  • Erythromycin belongs to group of drugs known as macrolide antibiotics, which work by stopping bacteria from making proteins that they need to survive and function properly. (everydayhealth.com)
  • Taking erythromycin for a long period of time may make you more likely to develop infections caused by bacteria or fungus that are much more difficult to treat. (everydayhealth.com)
  • First isolated from the soil fungus Streptomyces erythraeus in 1952 by a team of researchers led by American scientist J. M. McGuire, erythromycin is most successful at fighting gram-positive bacteria, though it also exhibits some action against some types of gram-negative bacteria. (fsu.edu)
  • I am trying to clon a cDNA (fused to GFP) in pTRKH3 but when I do the transformation (using DH5alpha) with Erythromycin (150ug/ml or 250ug/ml) the plate is full of bacteria (there are no colonies). (protocol-online.org)
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  • Erythromycin is used to treat or prevent many different types of infections caused by bacteria. (emedicinehealth.com)
  • Other antibiotics may be preferred for acne however, as strains of the Propionebacterium that are resistant to erythromycin are becoming widespread. (netdoctor.co.uk)
  • Erythromycin is in a class of medications called macrolide antibiotics. (medlineplus.gov)
  • Antibiotics such as erythromycin will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • The interest of this extract and its association with antibiotics was checked on P acnes strains presenting sensitivity or acquired resistance to erythromycin and clindamycin. (thefreedictionary.com)
  • The term erythromycins is used for a group of antibiotics that include not only erythromycin but also those chemically related to or derived from erythromycin, such as azithromycin (Zithromax) and clarithromycin (Biaxin) (Ross-Flanigan 2004). (newworldencyclopedia.org)
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  • Erythromycin belongs to the family of medicines called antibiotics. (allinahealth.org)
  • In these strains, erythromycin acts as an inducer of resistance to three different classes of inhibitors of the 50 S ribosomal subunit-the macrolides, lincosamides, and streptogramin B-type antibiotics. (asm.org)
  • Constitutively erythromycin-resistant strains which do not require the presence of erythromycin for expression of resistance can be selected on media containing antibiotics which belong to any one of the three classes. (asm.org)
  • 50 S ribosomal subunits isolated from induced or constitutively resistant cells show decreased ability to bind erythromycin and lincomycin, and possible enzymatic inactivation of these antibiotics has been rigorously excluded. (asm.org)
  • You are allergic to erythromycin or related lincomycin antibiotics, or any other ingredient in this medicine. (dokteronline.com)
  • 3.Milne RW, Coulthard K, Nation RL, Penna AC, Roberts G, Sansom LN. Lack of effect of erythromycin on the pharmacokinetics of single oral doses of phenytoin. (webmd.com)
  • Exposure to erythromycin (especially long courses at antimicrobial doses, and also through breastfeeding) has been linked to an increased probability of pyloric stenosis in young infants. (wikipedia.org)
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  • Erythromycin topical solution has been tested in children 12 years of age and older and, in effective doses, has not been shown to cause different side effects or problems than it does in adults. (allinahealth.org)
  • Upper respiratory tract infections of mild to moderate degree caused by Streptococcus pyogenes , Streptococcus pneumoniae , or Haemophilus influenzae (when used concomitantly with adequate doses of sulfonamides, since many strains of H. influenzae are not susceptible to the erythromycin concentrations ordinarily achieved). (wikidoc.org)
  • Although optimal dosage and duration have not been established, doses of erythromycin utilized in reported clinical studies were 40 to 50 mg/kg/day, given in divided doses for 5 to 14 days. (wikidoc.org)
  • These are usually mild erythromycin 125mg may be reduced by taking your doses after a meal or snack. (thedomains.com)
  • There is not enough evidence to show any benefit from erythromycin used in large or small doses for the prevention or treatment of feeding problems in premature infants. (cochrane.org)
  • However, this review found that there is not enough evidence to recommend the use of erythromycin in small or large doses to prevent or treat premature infants with feeding problems. (cochrane.org)
  • There is insufficient evidence to recommend the use of erythromycin in low or high doses for preterm infants with or at risk of feeding intolerance. (cochrane.org)
  • 17 ), who found that low doses of an erythromycin-like compound, EM-574, were ineffective at increasing gastroduodenal motility during vagal cooling. (physiology.org)
  • Ophthalmic erythromycin is used to treat bacterial infections of the eye. (medlineplus.gov)
  • Erythromycin is used to treat a wide variety of bacterial infections . (webmd.com)
  • Erythromycin topical (for the skin) is used to treat bacterial infections such as severe acne. (wellspan.org)
  • Erythromycin is prescribed to treat short-term acute bacterial infections, such as chest respiratory infections, urine infections, skin infections, and mouth infections. (thedomains.com)
  • For respiratory tract infections, erythromycins have better coverage of atypical organisms , including mycoplasma and Legionellosis. (newworldencyclopedia.org)
  • Azithromycin and clarithromycin are better than erythromycin at reaching the lungs and respiratory tract, and thus are preferred for respiratory tract infections. (newworldencyclopedia.org)
  • In humans Erythromycin is often used respiratory tract infections, which of coarse does not exist in fish (gills versus lungs). (liberalconspiracy.org)
  • This pictures skin injuries, respiratory tract infections, chlamydia infections, jeopardy erythromycin 125mg pelvic inflammatory disease. (thedomains.com)
  • Erythromycin comes as a capsule, tablet, delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) capsule, delayed-release tablet, and an oral suspension (liquid) to take by mouth. (medlineplus.gov)
  • Erythromycin ophthalmic may also be used for purposes not listed in this medication guide. (rexhealth.com)
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  • Erythromycin is taken for several days and can result in stomach upset in some patients, causing them to stop taking the medication. (clinicaltrials.gov)
  • What conditions does Erythromycin Stearate treat? (webmd.com)
  • List Erythromycin Stearate side effects by likelihood and severity. (webmd.com)
  • In one large cohort from Canada, older adults taking an implicated statin alongside erythromycin or clarithromycin were significantly more likely to be admitted to hospital with rhabdomyolysis or acute kidney injury, and significantly more likely to die within 30 days than similar adults taking azithromycin instead. (thefreedictionary.com)
  • Erythromycin may also be prescribed to prevent this infection in people who haven't been vaccinated against whooping cough and who are in close contact with someone who has it. (netdoctor.co.uk)
  • Erythromycin may also used to prevent bacterial infection following surgery, burns or trauma. (netdoctor.co.uk)
  • The dose of erythromycin prescribed, how often to take it and how long for, depends on the type of infection you have, your age and your kidney function. (netdoctor.co.uk)
  • Erythromycin is usually taken twice a day (every 12 hours) or four times a day (every six hours), depending on the type of infection being treated. (netdoctor.co.uk)
  • Unless your doctor tells you otherwise, it is important that you finish the prescribed course of erythromycin, even if you feel better or it seems the infection has cleared up. (netdoctor.co.uk)
  • Erythromycin is also used sometimes used to prevent heart infection in people having dental or other procedures. (medlineplus.gov)
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  • Erythromycin injection is given as an infusion into a vein, for a severe infection. (emedicinehealth.com)
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  • Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells," American Journal of Respiratory and Critical Care Medicine , vol. 165, no. 8, pp. 1113-1118, 2002. (hindawi.com)
  • The Global Erythromycin Industry Report 2016 is a professional and in-depth study on the current state of the Erythromycin industry. (mynewsdesk.com)
  • On August 2, 2016 Japan notified its draft amendment related to MRLs for Erythromycin in foods to the World Trade Organization (WTO). (sgs.com)
  • What are the possible side effects of erythromycin ophthalmic? (rexhealth.com)
  • Potential side effects of erythromycin include vomiting, diarrhea, stomach cramps and mild skin rash. (reference.com)
  • The effects of erythromycin lactobionate (10 mg/kg) on transpyloric flow pattern and pyloric resistance were evaluated during repetitive bilateral vagal cooling in anesthetized pigs. (physiology.org)
  • Presently, erythromycin is commonly used off-label for gastric motility indications such as gastroparesis . (thefullwiki.org)
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  • tell your doctor and pharmacist if you are allergic to erythromycin, any other medications, or any of the ingredients in erythromycin capsules, tablets, or suspension. (medlineplus.gov)
  • You should not use this medicine if you are allergic to erythromycin. (rexhealth.com)
  • Some patients are allergic to erythromycin and might experience swelling of the eyelids and pain in the eye. (wisegeek.com)
  • Over the years since the discovery of erythromycin A and its activity as an antimicrobial, many attempts have been made to synthesize it in the laboratory. (thefullwiki.org)
  • A rapid and simple microdilution technique on 96-well microplate based on turbidimetry was optimized and validated for screening of antimicrobial activity against erythromycin-resistant bacterial strains of Streptococcus pyogenes and Staphylococcus simulans isolated from Finnish patients. (springer.com)
  • More than one in five invasive GAS infections are caused by throat--imagine if it were erythromycin- and clindamycin-resistant strains, limiting the untreatable. (cdc.gov)
  • 5% to erythromycin and other macrolides, and to clindamycin complicates the treatment of both strep throat and severe c ent of R er invasive infections. (cdc.gov)
  • 10,11,12) Staphylococcal isolates with msr A-mediated efflux mechanism also appear erythromycin resistant and clindamycin susceptible by in vitro tests, but such isolates do not become clindamycin resistant in vivo. (thefreedictionary.com)
  • Erythromycin 250 mg / 5 ml Oral Suspension 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each 5 ml of reconstituted product contains 250 mg of erythromycin as erythromycin ethyl succinate. (liberalconspiracy.org)
  • To evaluate the efficacy of early treatment with erythromycin on the duration of fecal excretion and of diarrhea associated with Campylobacter jejuni, 170 patients, age 3 to 60 months, were randomly assigned in a double-blind fashion to receive either erythromycin ethyl succinate or placebo immediately after being seen at Cayetano Heredia Hospital because of acute dysentery. (nih.gov)
  • Through a MEDLINE search of all English medical literature (1966 to 1994) documenting possible interactions between quinidine and erythromycin, retrospective patient chart review, and analysis of the relationship between serum quinidine concentrations and significant clinical events, deduce the possibility of a quinidine and erythromycin pharmacokinetic and pharmacodynamic interaction in this particular patient case. (biomedsearch.com)
  • Erythromycin estolate has been associated with reversible hepatotoxicity in pregnant women in the form of elevated serum glutamic-oxaloacetic transaminase and is not recommended during pregnancy. (wikipedia.org)
  • The pain often occurs once or a few times daily, erythromycin estolate 250 mg typically two to three … 4/5 (30) [PDF] Erythromycin Suspension - medSask https://medsask. (liberalconspiracy.org)
  • How do I take erythromycin? (netdoctor.co.uk)
  • Take erythromycin exactly as directed. (medlineplus.gov)
  • Continue to take erythromycin even if you feel well. (medlineplus.gov)
  • tell your doctor if you are taking astemizole (Hismanal) (not available in the U.S.), cisapride (Propulsid) (not available in the U.S.), dihydroergotamine (DHE 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), pimozide (Orap), or terfenadine (Seldane) (not available in the U.S.). Your doctor will probably tell you not to take erythromycin if you are taking one or more of these medications. (medlineplus.gov)
  • It is best to take erythromycin one hour before or two hours after meals and to avoid taking erythromycin with fruit juices and carbonated beverages. (reference.com)
  • [2] Erythromycin also appears to be safe to use during pregnancy. (wikipedia.org)
  • How much does erythromycin suspension cost erythromycin 250 mg in pregnancy. (liberalconspiracy.org)
  • FDA pregnancy category C. It is not known whether benzoyl peroxide and erythromycin topical will harm an unborn baby. (cigna.com)
  • Erythromycin is a pregnancy category B drug, which means it should be generally safe to use in pregnancy. (everydayhealth.com)
  • It's Securely to Buy at Discounts Erythromycin 500mg Online. (lanyrd.com)
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  • Ophthalmic erythromycin is usually applied one time in the hospital soon after delivery to prevent eye infections in newborn babies. (medlineplus.gov)
  • Does long-term erythromycin treatment reduce the number of common cold infections and subsequent exacerbations in patients with chronic obstructive pulmonary disease (COPD)? (nih.gov)
  • In pregnant patients, the CDC recommends additional regimens of erythromycin base 250 mg PO or erythromycin 400 mg PO 4 times daily for 14 days as an alternative to azithromycin or amoxicillin in chlamydial infections. (liberalconspiracy.org)
  • EMGEL (erythromycin) Topical Gel is indicated for the topical treatment of acne vulgaris . (rxlist.com)
  • BENZAMYCIN (erythromycin) Topical Gel is indicated for the topical treatment of acne vulgaris . (rxlist.com)
  • Many other medications may also interact with erythromycin, so tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting erythromycin. (medhelp.org)
  • Therefore, before using erythromycin, report all medications you are currently using to your doctor or pharmacist. (medhelp.org)
  • Avoid using other medications on the areas you treat with benzoyl peroxide and erythromycin topical unless your doctor tells you to. (cigna.com)
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  • At least two functionally different types of ribosomes are found in strains of Staphylococcus aureus which display "dissociated" resistance to erythromycin. (asm.org)
  • Latest prescription information about Erythromycin. (medindia.net)
  • Bottles of erythromycin suspension should be shaken before measuring out a dose. (netdoctor.co.uk)
  • Erythromycin suspension - an additional. (thedomains.com)
  • Erythromycin has a similar range of antibacterial activity to penicillin and so is also useful as an alternative to penicillin in people who are allergic to penicillins. (netdoctor.co.uk)
  • Pseudomembranous colitis has been reported with nearly all antibacterial agents, including erythromycin , and may range in severity from mild to life-threatening. (rxlist.com)
  • This is zithromax erythromycin especially buffalo's most other levaquin antibacterial. (sezame.cz)
  • In this study, Erythromycin was one of the drugs that had an inhibitory effect on the bacterial population. (sourcewatch.org)
  • [11] Of those tested, Philadelphia tested positive for erythromycin (as well as 55 other drugs). (sourcewatch.org)
  • What other drugs will affect erythromycin ophthalmic? (rexhealth.com)
  • The activity of the CYP3A enzymes can be induced or inhibited by certain drugs (e.g., dexamethasone), which can cause it to affect the metabolism of many different drugs, including erythromycin. (wikipedia.org)
  • If other CYP3A substrates - drugs that are broken down by CYP3A - such as simvastatin (Zocor), lovastatin (Mevacor), or atorvastatin (Lipitor)-are taken concomitantly with erythromycin, levels of the substrates increase, often causing adverse effects. (wikipedia.org)
  • Erythromycin interacts with many more drugs than what appears here, so be sure to talk to you pharmacist or doctor before taking erythromycin. (everydayhealth.com)
  • 4.Bachmann K, Schwartz JI, Forney RB Jr, Jauregui L. Single dose phenytoin clearance during erythromycin treatment. (webmd.com)
  • Low-dose erythromycin therapy (EM) (400 to 600 mg/d) has been found to improve the survival of patients with DPB, and most patients with DPB in Japan have been treated with this erythromycin regime since 1984. (nih.gov)
  • A single dose of 200 mg erythromycin has been shown to induce a prolonged period of enhanced phasic contractile activity. (clinicaltrials.gov)
  • Eli Lilly's research team, led by J. M. McGuire, managed to isolate Erythromycin from the metabolic products of a strain of Streptomyces erythreus (designation changed to " Saccharopolyspora erythraea ") found in the samples. (princeton.edu)
  • He was glucocorticoid at keeping me therapeutic, purchase and erythromycin making fat i was senior. (site-du-hdmi.com)
  • Erythromycin is a motilin agonist that exerts its prokinetic effect by stimulating propagative contractile activity in the interdigestive phase. (cochrane.org)
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  • No Prescription Needed for Erythromycin. (lanyrd.com)
  • You should not use this medicine if you are allergic to benzoyl peroxide or erythromycin (Akne-Mycin, Eryderm, Erythrocin, Pediazole, and others). (cigna.com)
  • Erythromycin Lactobionate infusion: 200 mg i.v. infusion over a period of 20 minutes. (clinicaltrials.gov)
  • Places to purchase erythromycin 125mg online pay with paypal? (thedomains.com)
  • Each gram of Erythromycin Topical Gel USP, 2% (clear, colorless, gel) contains 20 mg of erythromycin USP in a vehicle consisting of alcohol (92% v/v) and hydroxypropyl cellulose. (nih.gov)
  • Erythromycin Topical Gel USP, 2% is contraindicated in those individuals who have shown hypersensitivity to any of its components. (nih.gov)
  • ERYTHROMYCIN powder helps broad spectrum treatment and control of bacterial disease, such as body slime, mouth fungus, Furunculosis (open lesions and swelling), bacterial gill disease and hemorrhagic septicemia (blood spots without sign of skin damage). (liberalconspiracy.org)
  • Patients were randomly assigned to erythromycin therapy or to no active treatment in September 1997. (nih.gov)
  • Erythromycin may interfere with the absorption and/or activity of calcium , folic acid , magnesium , vitamin B6 and vitamin B12 , which may cause problems, especially with long-term erythromycin treatment. (adventisthealthcare.com)
  • The purpose of this study was to evaluate the effects of treatment with erythromycin on the survival rate of patients with DPB in Japan. (nih.gov)
  • Doxycycline is allergy erythromycin doxycycline excreted in treatment thatdoesnt. (infoglob.se)
  • After 2 days of treatment, none of the patients in the placebo group and 36% of those in the erythromycin group had normal stools (P less than 0.05). (nih.gov)
  • In the category Acne treatment you will find alternatives, like Erythromycin . (dokteronline.com)
  • Clinical studies have provided evidence that erythromycin is the first-line treatment. (curehunter.com)
  • To evaluate the efficacy of erythromycin in the prevention and treatment of feeding intolerance in preterm infants. (cochrane.org)
  • Ng E, Shah VS. Erythromycin for the prevention and treatment of feeding intolerance in preterm infants. (cochrane.org)
  • Use ophthalmic erythromycin until you finish the prescription, even if you feel better. (medlineplus.gov)
  • Sometimes patients taking Erythromycin experience side effects. (sourcewatch.org)
  • Although there is no specific information comparing use of topical erythromycin in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. (allinahealth.org)
  • However, this protocol requires a multi-day dosing regimen of erythromycin and it has been known to have untoward gastrointestinal side effects leading to decreased patient compliance. (clinicaltrials.gov)
  • in addition many of the unwanted side effects seen with erythromycin are not seen or greatly reduced with azithromycin, making it an attractive alternative. (clinicaltrials.gov)
  • Erythromycin MG Mustard also have few side effects. (thedomains.com)
  • Erythromycin gastro-resistant tablets and capsules should be swallowed whole with a drink and not broken, crushed or chewed. (netdoctor.co.uk)
  • Pharmaceutical company Amneal Pharmaceuticals reported on Wednesday the receipt of approval from the US FDA for Erythromycin Tablets USP in 250 mg and 500 mg strengths. (thefreedictionary.com)
  • Enhancement of gastric outflow by erythromycin is also modulated by the vagus, since pyloric resistance was able to overcome increased gastric motility. (physiology.org)
  • Erythromycin topical preparations are used on the skin to help control acne. (allinahealth.org)
  • It is a white crystalline powder and has a solubility of approximately 1 mg/mL in water and is soluble in alcohol at 25°C. Benzamycin (erythromycin) ® Pak also contains benzoyl peroxide for topical use. (rxlist.com)
  • What is the most important information I should know about benzoyl peroxide and erythromycin topical? (cigna.com)
  • Benzoyl peroxide and erythromycin topical (for the skin) is a combination medicine used to treat acne. (cigna.com)
  • What should I discuss with my healthcare provider before using benzoyl peroxide and erythromycin topical? (cigna.com)
  • It is not known whether benzoyl peroxide and erythromycin topical passes into breast milk or if it could harm a nursing baby. (cigna.com)
  • How should I use benzoyl peroxide and erythromycin topical? (cigna.com)
  • Benzoyl peroxide and erythromycin topical is usually applied twice daily in the morning and evening. (cigna.com)
  • Do not cover the treated skin area after applying benzoyl peroxide and erythromycin topical. (cigna.com)
  • An overdose of benzoyl peroxide and erythromycin topical is not expected to be dangerous. (cigna.com)
  • What should I avoid while taking benzoyl peroxide and erythromycin topical? (cigna.com)
  • Also avoid using benzoyl peroxide and erythromycin topical on wounds or on areas of eczema. (cigna.com)
  • If you have diarrhea that is watery or bloody, stop using benzoyl peroxide and erythromycin topical and call your doctor. (cigna.com)
  • Avoid using sunscreen containing PABA on the same skin treated with benzoyl peroxide and erythromycin topical, or skin discoloration may occur. (cigna.com)
  • It is sometimes sold under the brand names ERY-C, Ery-Tab, Erythromycin Base Filmtab, and PCE® Dispertab. (sourcewatch.org)
  • If you become pregnant while taking erythromycin, call your doctor. (medlineplus.gov)