Erythromycin. Medical search

A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

A macrolide antibiotic, produced by Streptomyces erythreus. It is the lauryl sulfate salt of the propionic ester of erythromycin. This erythromycin salt acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

Substances that reduce the growth or reproduction of BACTERIA.

A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.

An antibiotic complex produced by Streptomyces kitasatoensis. The complex consists of a mixture of at least eight biologically active components, A1 and A3 to A9. Leucomycins have both antibacterial and antimycoplasmal activities.

An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.

Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).

A genus of gram-positive bacteria whose spores are round to oval and covered by a sheath.

An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.

The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.

Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections.

Compounds based on ERYTHROMYCIN with the 3-cladinose replaced by a ketone. They bind the 23S part of 70S bacterial RIBOSOMES.

A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.

The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.

A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER.

A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.

A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.

Infections with bacteria of the genus STREPTOCOCCUS.

A macrolide antibiotic that has a wide antimicrobial spectrum and is particularly effective in respiratory and genital infections.

A cyclic polypeptide antibiotic complex from Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. It consists of 2 major components, VIRGINIAMYCIN FACTOR M1 and virginiamycin Factor S1. It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine, and poultry.

A family of LINCOMYCIN-related glycosides that contain a pyrrolidine ring linked via an amide-bond to a pyranose moiety. Individual members of this family are defined by the arrangement of specific constituent groups on the lyncomycin molecule. Many lincosamides are ANTIBIOTICS produced by a variety STREPTOMYCES species.

A peptide of about 22-amino acids isolated from the DUODENUM. At low pH it inhibits gastric motor activity, whereas at high pH it has a stimulating effect.

Antibiotic macrolide produced by Streptomyces antibioticus.

A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)

An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)

A macrolide antibiotic that is similar to ERYTHROMYCIN.

A species of gram-negative, rod-shaped bacteria isolated from the intestinal tract of swine, poultry, and man. It may be pathogenic.

Nonsusceptibility of bacteria to the action of TETRACYCLINE which inhibits aminoacyl-tRNA binding to the 30S ribosomal subunit during protein synthesis.

The evacuation of food from the stomach into the duodenum.

Nonsusceptibility of an organism to the action of penicillins.

A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.

Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.

A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.

A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.

Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.

The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Deoxyribonucleic acid that makes up the genetic material of bacteria.

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

Proteins found in any species of bacterium.

Constituent of 50S subunit of prokaryotic ribosomes containing about 3200 nucleotides. 23S rRNA is involved in the initiation of polypeptide synthesis.

The functional hereditary units of BACTERIA.

A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.

A bacterium which causes mastitis in cattle and occasionally in man.

Gram-negative aerobic rods, isolated from surface water or thermally polluted lakes or streams. Member are pathogenic for man. Legionella pneumophila is the causative agent for LEGIONNAIRES' DISEASE.

A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.

A genus of bacteria found in the reproductive organs, intestinal tract, and oral cavity of animals and man. Some species are pathogenic.

Macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans.

A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.

Multicomponent ribonucleoprotein structures found in the CYTOPLASM of all cells, and in MITOCHONDRIA, and PLASTIDS. They function in PROTEIN BIOSYNTHESIS via GENETIC TRANSLATION.

Infections with bacteria of the genus STAPHYLOCOCCUS.

The motor activity of the GASTROINTESTINAL TRACT.

A species of gram-positive, coccoid bacteria commonly isolated from clinical specimens and the human intestinal tract. Most strains are nonhemolytic.

A species of bacteria that resemble small tightly coiled spirals. Its organisms are known to cause abortion in sheep and fever and enteritis in man and may be associated with enteric diseases of calves, lambs, and other animals.

Process of determining and distinguishing species of bacteria or viruses based on antigens they share.

A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.

Inflammation of the throat (PHARYNX).

An acute, sometimes fatal, pneumonia-like bacterial infection characterized by high fever, malaise, muscle aches, respiratory disorders and headache. It is named for an outbreak at the 1976 Philadelphia convention of the American Legion.

Physiological role of the N-terminal processed P4501A1 targeted to mitochondria in erythromycin metabolism and reversal of erythromycin-mediated inhibition of mitochondrial protein synthesis. (1/2077)

Recently, we showed that the major species of beta-naphthoflavone-inducible rat liver mitochondrial P450MT2 consists of N-terminal truncated microsomal P4501A1 (+33/1A1) and that the truncated enzyme exhibits different substrate specificity as compared with intact P4501A1. The results of the present study show that P450MT2 targeted to COS cell mitochondria by transient transfection of P4501A1 cDNA is localized inside the mitochondrial inner membrane in a membrane-extrinsic orientation. Co-expression with wild type P4501A1 and adrenodoxin (Adx) cDNAs resulted in 5-7-fold higher erythromycin N-demethylation (ERND) in the mitochondrial fraction but minimal changes in the microsomal fraction of transfected cells. Erythromycin, a potent inhibitor of bacterial and mitochondrial protein synthesis, caused 8-12-fold higher accumulation of CYP1A1 mRNA, preferential accumulation of P450MT2, and 5-6-fold higher ERND activity in the mitochondrial compartment of rat C6 glioma cells. Consistent with the increased mitochondrial ERND activity, co-expression with P4501A1 and Adx in COS cells rendered complete protection against erythromycin-mediated mitochondrial translation inhibition. Mutations that specifically affect the mitochondrial targeting of P4501A1 also abolished protection against mitochondrial translation inhibition. These results for the first time suggest a physiological function for the xenobiotic inducible cytochrome P4501A1 against drug-mediated mitochondrial toxicity. (+info)

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. (2/2077)

The structures of complex polyketide natural products, such as erythromycin, are programmed by multifunctional polyketide synthases (PKSs) that contain modular arrangements of functional domains. The colinearity between the activities of modular PKS domains and structure of the polyketide product portends the generation of novel organic compounds-"unnatural" natural products-by genetic manipulation. We have engineered the erythromycin polyketide synthase genes to effect combinatorial alterations of catalytic activities in the biosynthetic pathway, generating a library of >50 macrolides that would be impractical to produce by chemical methods. The library includes examples of analogs with one, two, and three altered carbon centers of the polyketide products. The manipulation of multiple biosynthetic steps in a PKS is an important milestone toward the goal of producing large libraries of unnatural natural products for biological and pharmaceutical applications. (+info)

Increased activity of 16-membered lactone ring macrolides against erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae: characterization of South African isolates. (3/2077)

The susceptibility of 40 erythromycin-resistant isolates of Streptococcus pyogenes and 40 multiply-resistant isolates of Streptococcus pneumoniae to six macrolide antibiotics, representing 14-, 15- and 16-membered lactone ring structures, was tested. The genetic basis for macrolide resistance in the strains was also determined. Both erm and mef determinants were encountered in the 36 S. pneumoniae isolates tested, but only mef in the five S. pyogenes isolates tested. All isolates showed cross-resistance among the 14-membered macrolides erythromycin, clarithromycin and roxithromycin and the 15-membered macrolide, azithromycin. However, the erythromycin-resistant S. pyogenes isolates retained full susceptibility to spiramycin and josamycin (16-membered agents). These latter two antibiotics were also more active than the other macrolides against erythromycin-resistant S. pneumoniae isolates, especially josamycin which was 8-64 times more active than erythromycin; spiramycin was only two to eight times more active than erythromycin. (+info)

A pilot study of low-dose erythromycin in bronchiectasis. (4/2077)

Patients with bronchiectasis suffer from sputum production, recurrent exacerbations, and progressive airway destruction. Erythromycin is effective in diffuse panbronchiolitis, another suppurative airway disorder, although its efficacy is unknown in idiopathic bronchiectasis. A double-blind placebo-controlled study was therefore conducted to evaluate the effects of 8-week administration of low dose erythromycin (500 mg b.i.d.) in steady-state idiopathic bronchiectasis. Patients in the erythromycin group (n=11, 8 female, mean age 50+/-15 yrs), but not the placebo group (n=10, 8 female, mean age 59+/-16 yrs) had significantly improved forced expiratory volume in one second, forced vital capacity and 24-h sputum volume after 8 weeks (p<0.05). There was no parallel improvement in sputum pathogens, leukocytes, interleukin (IL)-1alpha and IL-8, tumour necrosis factor-alpha, or leukotriene B4. The results of this pilot study show that low-dose erythromycin improves lung function and sputum volume in bronchiectasis. Further studies are indicated to evaluate the efficacy of long-term erythromycin therapy in bronchiectasis. (+info)

Extremely high incidence of macrolide and trimethoprim-sulfamethoxazole resistance among clinical isolates of Streptococcus pneumoniae in Taiwan. (5/2077)

From January 1996 to December 1997, 200 isolates of Streptococcus pneumoniae recovered from 200 patients treated at National Taiwan University Hospital were serotyped and their susceptibilities to 16 antimicrobial agents were determined by the agar dilution method. Sixty-one percent of the isolates were nonsusceptible to penicillin, exhibiting either intermediate resistance (28%) or high-level resistance (33%). About two-fifths of the isolates displayed intermediate or high-level resistance to cefotaxime, ceftriaxone, cefepime, imipenem, and meropenem. Extremely high proportions of the isolates were resistant to erythromycin (82%), clarithromycin (90%), and trimethoprim-sulfamethoxazole (TMP-SMZ) (87%). Among the isolates nonsusceptible to penicillin, 23.8% were resistant to imipenem; more than 60% displayed resistance to cefotaxime, ceftriaxone, cefepime, and carbapenems; 96.7% were resistant to erythromycin; and 100% were resistant to TMP-SMZ. All isolates were susceptible to rifampin and vancomycin. The MICs at which 50% and 90% of the isolates were inhibited were 0.12 and 1 microgram/ml, respectively, for cefpirome, and 0.12 and 0.25 microgram/ml, respectively, for moxifloxacin. Six serogroups or serotypes (23F, 19F, 6B, 14, 3, and 9) accounted for 77.5% of all isolates. Overall, 92.5% of the isolates were included in the serogroups or serotypes represented in the 23-valent pneumococcal vaccine. The incidence of macrolide and TMP-SMZ resistance for S. pneumoniae isolates in Taiwan in this study is among the highest in the world published to date. (+info)

Erythromycin enhances early postoperative contractility of the denervated whole stomach as an esophageal substitute. (6/2077)

OBJECTIVE: To determine whether early postoperative administration of erythromycin accelerates the spontaneous motor recovery process after elevation of the denervated whole stomach up to the neck. SUMMARY BACKGROUND DATA: Spontaneous motor recovery after gastric denervation is a slow process that progressively takes place over years. METHODS: Erythromycin was administered as follows: continuous intravenous (i.v.) perfusion until postoperative day 10 in ten whole stomach (WS) patients at a dose of either 1 g (n = 5) or 2 g (n = 5) per day; oral intake at a dose of 1 g/day during 1.5 to 8 months after surgery in 11 WS patients, followed in 7 of them by discontinuation of the drug during 2 to 4 weeks. Gastric motility was assessed with intraluminal perfused catheters in these 21 patients, in 23 WS patients not receiving erythromycin, and in 11 healthy volunteers. A motility index was established by dividing the sum of the areas under the curves of >9 mmHg contractions by the time of recording. RESULTS: The motility index after IV or oral administration of erythromycin at and after surgery was significantly higher than that without erythromycin (i.v., 1 g: p = 0.0090; i.v., 2 g: p = 0.0090; oral, 1 g: p = 0.0017). It was similar to that in healthy volunteers (i.v., 1 g: p = 0.2818; oral, 1 g: p = 0.7179) and to that in WS patients with >3 years of follow-up who never received erythromycin (i.v., 1 g: p = 0.2206; oral, 1 g: p = 0.8326). The motility index after discontinuation of the drug was similar or superior to that recorded under medication in four patients who did not experience any modification of their alimentary comfort, whereas it dropped dramatically parallel to deterioration of the alimentary comfort in three patients. CONCLUSIONS: Early postoperative contractility of the denervated whole stomach pulled up to the neck under either i.v. or oral erythromycin is similar to that recovered spontaneously beyond 3 years of follow-up. In some patients, this booster effect persists after discontinuation of the drug. (+info)

Effect of cyclosporine A on cytochrome P-450-mediated drug metabolism in the partially hepatectomized rat. (7/2077)

Despite its hepatotoxic potential, cyclosporine A (CsA) has been reported to positively influence compensatory liver growth. To probe the physiological consequences of CsA on the recovery of liver function, studies were initiated in the 2/3 partially hepatectomized (PHx) rat, taking the recovery of cytochromes P-450-dependent drug metabolism as primary outcome. CsA was administered at a dose of 3. 33 mg/kg/day for 10 days. Drug metabolism was evaluated by the recovery of 14CO2 after administration of isotopically labeled model drugs and by studying the expression of the P-450 transcripts involved in their biotransformation before and 24 to 96 h after PHx. Before PHx, neither the steady-state mRNA nor the in vivo disposition of caffeine (CYP1A2), erythromycin (CYP3A2 and 3A1), or aminopyrine (CYP2B1 and 2C11) were influenced by CsA. Studies 24 h after PHx revealed a 29 to 39% reduction in the elimination of [14C]aminopyrine and [14C]erythromycin, which was unaffected by CsA. Their metabolism at 48 to 96 h after PHx also remained unaffected by CsA. By contrast, postPHx, [14C]caffeine elimination decreased to a level closely proportional to the loss in liver mass. In addition, CsA accelerated the recovery and/or prevented the decrease of caffeine elimination 24 h after PHx but not at later time points, indicating an early, but unsustained, beneficial effect of CsA on the recovery of CYP1A2-mediated activities. These data show that at the critical time of greatest loss in liver mass, CsA has only a selective influence on the biotransformation of cytochrome P-450 protein-dependent activities and that its effect on the regeneration process does not translate into an overall accelerated recovery of the hepatic drug-metabolizing function. (+info)

Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors. (8/2077)

Macrolide antibiotics such as erythromycin have been reported to be effective for asthma. However, the precise mechanisms of this effect remain unclear. We studied the effect of erythromycin, clarithromycin, josamycin, and other antibiotics on the release by eosinophils of interleukin-8 (IL-8), a potent chemokine for inflammatory cells, including eosinophils themselves. Human eosinophils were isolated from atopic patients, and the effects of the drugs on IL-8 release were evaluated. Only 14-member macrolides (erythromycin and clarithromycin) showed a concentration-dependent suppressive effect on IL-8 release (control, 100%; erythromycin at 1 microgram/ml, 67.82% +/- 3.45% [P < 0.01]; clarithromycin at 5 micrograms/ml, 56.81% +/- 9.61% [P < 0.01]). The effect was found at therapeutic concentrations and appeared to occur at the posttranscriprtional level. In contrast, a 16-member macrolide (josamycin) had no significant effect. We suggest that 14-member macrolides inhibit IL-8 release by eosinophils and may thereby prevent the autocrine cycle necessary for the recruitment of these cells into the airways. (+info)

... A has been found to have the most antibacterial activity, followed by erythromycin B. Erythromycins C and D are ... Erythromycin/tretinoin, a combination of tretinoin and the antibiotic erythromycin "Erythromycin". The American Society of ... The following erythromycin combinations are available for oral dosage: erythromycin base (capsules, tablets) erythromycin ... erythromycin gluceptate erythromycin lactobionate For ophthalmic use: erythromycin base (ointment) Gastrointestinal ...

https://en.wikipedia.org/wiki/Erythromycin

... (EC 1.14.13.154, EryK) is an enzyme with systematic name erythromycin-D,NADPH:oxygen oxidoreductase ... erythromycin C + NADP+ + H2O Erythromycin 12 hydroxylase is responsible for the C-12 hydroxylation of the macrolactone ring. ... Erythromycin+12+hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology v t e ( ... Lambalot RH, Cane DE, Aparicio JJ, Katz L (February 1995). "Overproduction and characterization of the erythromycin C-12 ...

https://en.wikipedia.org/wiki/Erythromycin_12_hydroxylase

The erythromycin breath test (ERMBT) is a method used to measure metabolism (oxidation and elimination from the system) by a ... Erythromycin is tagged with carbon-14 and given as an intravenous injection; after 20 minutes the subject blows up a balloon ... Erythromycin produces 14CO2, and this 14CO2 can be measured to study drugs that interact with the cytochrome P450 system. ... Erythromycin is a drug that treats bacterial infections like bronchitis, sexually transmitted diseases, and pneumonia. The ...

https://en.wikipedia.org/wiki/Erythromycin_breath_test

... erythromycin B The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C. Paulus TJ, Tuan JS, Luebke VE, ... erythromycin A (2) S-adenosyl-L-methionine + erythromycin D ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + ... Erythromycin+3''-O-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology v t ... Erythromycin 3''-O-methyltransferase (EC 2.1.1.254, EryG) is an enzyme with systematic name S-adenosyl-L-methionine: ...

https://en.wikipedia.org/wiki/Erythromycin_3''-O-methyltransferase

"ERYTHROMYCIN". Br Med J. 2 (4793): 1085-6. November 1952. doi:10.1136/bmj.2.4793.1085. PMC 2022076. PMID 12987755. Anderson, ... erythromycin (discovered at Eli Lilly and Co.) and their extension to an increasingly wide range of bacterial pathogens. ...

https://en.wikipedia.org/wiki/Pharmaceutical_industry

Erythromycin-based medications can also be used. A single study suggests superiority of azithromycin over doxycycline. Another ... "Erythromycin" (PDF). Davis. 2017. Archived from the original (PDF) on 2017-09-10. Retrieved March 24, 2017. "Pelvic ...

https://en.wikipedia.org/wiki/Pelvic_inflammatory_disease

Erythromycin, Saccharopolyspora erythraea. Nystatin, from Streptomyces noursei. Rifamycin, from Amycolatopsis rifamycinica. ...

https://en.wikipedia.org/wiki/Secondary_metabolite

Erythromycin, an antibiotic. Aflatoxin B1 known carcinogenic compounds Macrolides Pikromycin, the first isolated macrolide ( ... 1951) The antibiotics erythromycin A, clarithromycin, and azithromycin The antihelminthics ivermectin Ansamycins The antitumor ...

https://en.wikipedia.org/wiki/Polyketide

Erythromycin is similar. A 4.8% tranexamic acid solution is sometimes used as an antifibrinolytic mouthwash to prevent bleeding ...

https://en.wikipedia.org/wiki/Mouthwash

... produces erythromycin. Miller, E. S.; Woese, C. R.; Brenner, S. (1 July 1991). "Description of the ... Harrell, Erin A.; Miller, Eric S. (21 April 2016). "Genome Sequence of Aeromicrobium erythreum NRRL B-3381, an Erythromycin- ... "Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum". Metabolic Engineering. 6 (4): 300 ... Erythromycin-Producing Bacterium Arthrobacter sp. Strain NRRL B-3381 as Aeromicrobium erythreum gen. nov., sp. nov". ...

https://en.wikipedia.org/wiki/Aeromicrobium_erythreum

... erythromycin precursor synthase) show only a 45% common identity. Note that unlike in the erythromycin precursor synthase, ... However, unlike erythromycin and its effective synthetic derivatives, it lacks a 12-hydroxyl group and a 3-methoxy group. This ... Like erythromycin, oleandomycin binds to the 50s subunit of bacterial ribosomes, inhibiting the completion of proteins vital to ... It is weaker than erythromycin. It used to be sold under the brand name Sigmamycine, combined with tetracycline, and made by ...

https://en.wikipedia.org/wiki/Oleandomycin

Erythromycin may be an alternative. For use in combination regimens for eradication of H. pylori in adults Imipenem/cilastatin ... vaccine Atracurium Neostigmine Suxamethonium Vecuronium Pyridostigmineα Vecuroniumα Aciclovir Azithromycin Erythromycin ...

https://en.wikipedia.org/wiki/WHO_Model_List_of_Essential_Medicines

Antibiotics, e.g. erythromycin, rifampicin. Ergot derivatives used to treat migraine or Parkinson's disease may cause an ...

https://en.wikipedia.org/wiki/Selective_norepinephrine_reuptake_inhibitor

Weisblum, B (March 1995). "Erythromycin resistance by ribosome modification". Antimicrobial Agents and Chemotherapy. 39 (3): ... or erythromycin ribosome methylase family of genes. Nearly 40 erm genes have been reported to date, which are transferred ...

https://en.wikipedia.org/wiki/Lincosamides

"Asymmetric total synthesis of erythromycin. 3. Total synthesis of erythromycin". Journal of the American Chemical Society. 103 ... Notable work during his postdoctoral career includes the total synthesis of erythromycin. RajanBabu was a Member of Research ...

https://en.wikipedia.org/wiki/T._V._Rajan_Babu

Human studies are planned for erythromycin. Erythromycin has been used successfully in patients with gastric issues. "myotonic ... A recent study in December 2015 showed that a common FDA approved antibiotic, Erythromycin reduced myotonia in mice. ... Nakamori M, Taylor K, Mochizuki H, Sobczak K, Takahashi MP (January 2016). "Oral administration of erythromycin decreases RNA ...

https://en.wikipedia.org/wiki/Myotonic_dystrophy

These include tetracycline, doxycycline, and erythromycin. Erythromycin may be used as a cream. Doxycycline is most often the ...

https://en.wikipedia.org/wiki/Perioral_dermatitis

Occasionally erythromycin ophthalmic ointment is recommended. Other antibiotics, such as chloramphenicol or amoxicillin may ...

https://en.wikipedia.org/wiki/Stye

Erythromycin has an advantage over metoclopramide in gastric emptying due to lack of central nervous system side-effects. It is ... Erythromycin and related antibiotics act as non-peptide motilin agonists, and are sometimes used for their ability to stimulate ... In the case of erythromycin, it is its hemiketal intermediate, formed after an oral dose in the low-pH environment of the ... However, some of erythromycin's properties, including antibiotic activity, are not appropriate for a drug designed for chronic ...

https://en.wikipedia.org/wiki/Motilin

The first macrolide discovered was erythromycin, which was first used in 1952. Erythromycin was widely used as a substitute to ... Macrolides, mainly erythromycin and clarithromycin, also have a class effect of QT prolongation, which can lead to torsades de ... The macrolide antibiotics erythromycin, clarithromycin, and roxithromycin have proven to be an effective long-term treatment ... In infants the use of erythromycin has been associated with pyloric stenosis. Some macrolides are also known to cause ...

https://en.wikipedia.org/wiki/Macrolide

... the antibiotics erythromycin, clarithromycin, or telithromycin; HIV protease inhibitors; the antidepressant nefazodone; the ...

https://en.wikipedia.org/wiki/Simvastatin

... erythromycin Mycoplasma pneumoniae - erythromycin Coxiella burnetti - doxycycline Legionella pneumophila - erythromycin, with ... Streptococcus pneumoniae - amoxicillin (or erythromycin in patients allergic to penicillin); cefuroxime and erythromycin in ...

https://en.wikipedia.org/wiki/Bacterial_pneumonia

... erythromycin has been shown to cause both QT prolongation and TdP. Erythromycin works inhibiting the CYP3A protein. Patients ... Macrolides Azithromycin Clarithromycin Erythromycin When taken independently, ...

https://en.wikipedia.org/wiki/Drug-induced_QT_prolongation

Unlike erythromycin, telithromycin is acid-stable and can therefore be taken orally while being protected from gastric acids. ... Telithromycin is a semi-synthetic erythromycin derivative. It is created by substituting a ketogroup for the cladinose sugar ... Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, telithromycin strongly bind ...

https://en.wikipedia.org/wiki/Telithromycin

... produces nonactin, erythromycin and werramycine. List of Streptomyces species LPSN bacterio.net ... "Isolation and partial purification of erythromycin from alkaliphilic Streptomyces werraensis isolated from Rajkot, India". ... "Isolation and partial purification of erythromycin from alkaliphilic Streptomyces werraensis isolated from Rajkot, India". ...

https://en.wikipedia.org/wiki/Streptomyces_werraensis

C. hominis is often resistant to erythromycin. Since cefotaxime use may be not appropriate for C. hominis endocarditis, an ...

https://en.wikipedia.org/wiki/Cardiobacterium_hominis

Erythromycin and Other Antibiotics, 303 pages, 1960. Centre for Transformative Innovation, Swinburne University of Technology ...

https://en.wikipedia.org/wiki/Mary_Ethel_Florey

US 4382086, Sciavolino, Frank C. & Hauske, James R., "9-Dihydro-11,12-ketal derivatives of erythromycin A and epi-erythromycin ... Diethyl carbonate is used as a solvent such as in erythromycin intramuscular injections. It can be used as a component of ... Anderson, Robert C.; Harris, Paul N.; Chen, K. K. (1955). "Further toxicological studies with ilotycin® (Erythromycin, Lilly ... US 4363803, Hauske, James R., "3",4"-Oxyallylene erythromycin and oleandomycin, composition and method of use", published 1982- ...

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Anatomy1

Organisms12

Diseases5

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes11

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Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. (2/2077)

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Macrolides

Leucomycins

Lincomycin

Microbial Sensitivity Tests

Saccharopolyspora

Clindamycin

Drug Resistance, Microbial

Azithromycin

Roxithromycin

Ketolides

Josamycin

Drug Resistance, Bacterial

Tetracycline

Streptococcus pyogenes

Streptococcus pneumoniae

Gastrointestinal Agents

Clarithromycin

Streptococcal Infections

Miocamycin

Virginiamycin

Lincosamides

Motilin

Oleandomycin

Penicillins

Chloramphenicol

Troleandomycin

Campylobacter coli

Tetracycline Resistance

Gastric Emptying

Penicillin Resistance

Methyltransferases

Pneumococcal Infections

Streptococcus

Staphylococcus

Staphylococcus aureus

Drug Resistance, Multiple, Bacterial

DNA, Bacterial

Anti-Infective Agents

Bacterial Proteins

RNA, Ribosomal, 23S

Genes, Bacterial

Penicillin G

Streptococcus agalactiae

Legionella

Cytochrome P-450 CYP3A

Campylobacter

Tylosin

R Factors

Ribosomes

Staphylococcal Infections

Gastrointestinal Motility

Enterococcus faecalis

Campylobacter jejuni

Serotyping

Ofloxacin

Plasmids

Conjugation, Genetic

Pharyngitis

Legionnaires' Disease

Physiological role of the N-terminal processed P4501A1 targeted to mitochondria in erythromycin metabolism and reversal of erythromycin-mediated inhibition of mitochondrial protein synthesis. (1/2077)

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. (2/2077)

Increased activity of 16-membered lactone ring macrolides against erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae: characterization of South African isolates. (3/2077)

A pilot study of low-dose erythromycin in bronchiectasis. (4/2077)

Extremely high incidence of macrolide and trimethoprim-sulfamethoxazole resistance among clinical isolates of Streptococcus pneumoniae in Taiwan. (5/2077)

Erythromycin enhances early postoperative contractility of the denervated whole stomach as an esophageal substitute. (6/2077)

Effect of cyclosporine A on cytochrome P-450-mediated drug metabolism in the partially hepatectomized rat. (7/2077)

Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors. (8/2077)

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