Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.
Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.
A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.
The formation of clumps of RED BLOOD CELLS under low or non-flow conditions, resulting from the attraction forces between the red blood cells. The cells adhere to each other in rouleaux aggregates. Slight mechanical force, such as occurs in the circulation, is enough to disperse these aggregates. Stronger or weaker than normal aggregation may result from a variety of effects in the ERYTHROCYTE MEMBRANE or in BLOOD PLASMA. The degree of aggregation is affected by ERYTHROCYTE DEFORMABILITY, erythrocyte membrane sialylation, masking of negative surface charge by plasma proteins, etc. BLOOD VISCOSITY and the ERYTHROCYTE SEDIMENTATION RATE are affected by the amount of erythrocyte aggregation and are parameters used to measure the aggregation.
Volume of circulating ERYTHROCYTES . It is usually measured by RADIOISOTOPE DILUTION TECHNIQUE.
The major sialoglycoprotein of the human erythrocyte membrane. It consists of at least two sialoglycopeptides and is composed of 60% carbohydrate including sialic acid and 40% protein. It is involved in a number of different biological activities including the binding of MN blood groups, influenza viruses, kidney bean phytohemagglutinin, and wheat germ agglutinin.
A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.
RED BLOOD CELL sensitivity to change in OSMOTIC PRESSURE. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst.
The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).
A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein contains no lipids or carbohydrates, is the predominant species of peripheral erythrocyte membrane proteins, and exists as a fibrous coating on the inner, cytoplasmic surface of the membrane.
Measurement of rate of settling of erythrocytes in anticoagulated blood.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)
ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC).
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
Proteins found in any species of protozoan.
The in vitro formation of clusters consisting of a cell (usually a lymphocyte) surrounded by antigenic cells or antigen-bearing particles (usually erythrocytes, which may or may not be coated with antibody or antibody and complement). The rosette-forming cell may be an antibody-forming cell, a memory cell, a T-cell, a cell bearing surface cytophilic antibodies, or a monocyte possessing Fc receptors. Rosette formation can be used to identify specific populations of these cells.
Molecular sites on or in some B-lymphocytes and macrophages that recognize and combine with COMPLEMENT C3B. The primary structure of these receptors reveal that they contain transmembrane and cytoplasmic domains, with their extracellular portion composed entirely of thirty short consensus repeats each having 60 to 70 amino acids.
The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.
The rate dynamics in chemical or physical systems.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Large woodland game BIRDS in the subfamily Meleagridinae, family Phasianidae, order GALLIFORMES. Formerly they were considered a distinct family, Melegrididae.
A system of universal human blood group isoantigens with many associated subgroups. The M and N traits are codominant and the S and s traits are probably very closely linked alleles, including the U antigen. This system is most frequently used in paternity studies.
A blood group consisting mainly of the antigens Fy(a) and Fy(b), determined by allelic genes, the frequency of which varies profoundly in different human groups; amorphic genes are common.
Molecules on the surface of some B-lymphocytes and macrophages, that recognize and combine with the C3b, C3d, C1q, and C4b components of complement.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
A family of membrane-associated proteins responsible for the attachment of the cytoskeleton. Erythrocyte-related isoforms of ankyrin attach the SPECTRIN cytoskeleton to a transmembrane protein (ANION EXCHANGE PROTEIN 1, ERYTHROCYTE) in the erythrocyte plasma membrane. Brain-related isoforms of ankyrin also exist.
Agglutination of ERYTHROCYTES by a virus.
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells. They are seen in thalassemias, enzymopathies, hemoglobinopathies, and after splenectomy.
A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
A method for the detection of very small quantities of antibody in which the antigen-antibody-complement complex adheres to indicator cells, usually primate erythrocytes or nonprimate blood platelets. The reaction is dependent on the number of bound C3 molecules on the C3b receptor sites of the indicator cell.
The sum of the weight of all the atoms in a molecule.
A genus of protozoa that comprise the malaria parasites of mammals. Four species infect humans (although occasional infections with primate malarias may occur). These are PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM OVALE, and PLASMODIUM VIVAX. Species causing infection in vertebrates other than man include: PLASMODIUM BERGHEI; PLASMODIUM CHABAUDI; P. vinckei, and PLASMODIUM YOELII in rodents; P. brasilianum, PLASMODIUM CYNOMOLGI; and PLASMODIUM KNOWLESI in monkeys; and PLASMODIUM GALLINACEUM in chickens.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.
Uninuclear cells or a stage in the life cycle of sporozoan protozoa. Merozoites, released from ruptured multinucleate SCHIZONTS, enter the blood stream and infect the ERYTHROCYTES.
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)
A group of familial congenital hemolytic anemias characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. The erythrocytes have increased osmotic fragility and are abnormally permeable to sodium ions.
An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)
A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
Stable chromium atoms that have the same atomic number as the element chromium, but differ in atomic weight. Cr-50, 53, and 54 are stable chromium isotopes.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed)
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Elements of limited time intervals, contributing to particular results or situations.
Proteins from BACTERIA and FUNGI that are soluble enough to be secreted to target ERYTHROCYTES and insert into the membrane to form beta-barrel pores. Biosynthesis may be regulated by HEMOLYSIN FACTORS.
Small, abnormal spherical red blood cells with more than the normal amount of hemoglobin.
Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2.
A blood group related both to the ABO and P systems that includes several different antigens found in most people on erythrocytes, in milk, and in saliva. The antibodies react only at low temperatures.
A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
An encapsulated lymphatic organ through which venous blood filters.
An intrinsic defect of erythrocytes inherited as an autosomal dominant trait. The erythrocytes assume an oval or elliptical shape.
Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.
An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.
GPI-linked membrane proteins broadly distributed among hematopoietic and non-hematopoietic cells. CD55 prevents the assembly of C3 CONVERTASE or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.
Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.
Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
A sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian cells.
Substances, usually of biological origin, that cause cells or other organic particles to aggregate and stick to each other. They include those ANTIBODIES which cause aggregation or agglutination of particulate or insoluble ANTIGENS.
The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 1.11.1.9.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.
Adherence of cells to surfaces or to other cells.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Immature, nucleated ERYTHROCYTES occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PRECURSOR CELLS and precedes formation of RETICULOCYTES. The normal series is called normoblasts. Cells called MEGALOBLASTS are a pathologic series of erythroblasts.
The relationship between an invertebrate and another organism (the host), one of which lives at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically.
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
Transport proteins that carry specific substances in the blood or across cell membranes.
Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
A commonly occurring abnormal hemoglobin in which lysine replaces a glutamic acid residue at the sixth position of the beta chains. It results in reduced plasticity of erythrocytes.
Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.
Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.
The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.
The larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g.
Various fish of the family SALMONIDAE, usually smaller than salmon. They are mostly restricted to cool clear freshwater. Some are anadromous. They are highly regarded for their handsome colors, rich well-flavored flesh, and gameness as an angling fish. The genera Salvelinus, Salmo, and ONCORHYNCHUS have been introduced virtually throughout the world.
An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.
Antibodies produced by a single clone of cells.
A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)
A cytotoxic member of the CYTOCHALASINS.
Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
A phenomenon manifested by an agent or substance adhering to or being adsorbed on the surface of a red blood cell, as tuberculin can be adsorbed on red blood cells under certain conditions. (Stedman, 25th ed)
A protozoan parasite of rodents transmitted by the mosquito Anopheles dureni.
A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
A sulfhydryl reagent that is widely used in experimental biochemical studies.
Multinucleate cells or a stage in the development of sporozoan protozoa. It is exemplified by the life cycle of PLASMODIUM FALCIPARUM in the MALARIA infection cycle.
The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.
The clumping together of suspended material resulting from the action of AGGLUTININS.
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.

Stomatocytosis is absent in "stomatin"-deficient murine red blood cells. (1/429)

To examine the relationship between erythrocyte membrane protein 7. 2b deficiency and the hemolytic anemia of human hereditary stomatocytosis, we created 7.2b knock-out mice by standard gene targeting approaches. Immunoblots showed that homozygous knock-out mice completely lacked erythrocyte protein 7.2b. Despite the absence of protein 7.2b, there was no hemolytic anemia and mouse red blood cells (RBCs) were normal in morphology, cell indices, hydration status, monovalent cation content, and ability to translocate lipids. The absence of the phenotype of hereditary stomatocytosis implies that protein 7.2b deficiency plays no direct role in the etiology of this disorder and casts doubt on the previously proposed role of this protein as a mediator of cation transport in RBC.  (+info)

Plasmodium falciparum infection: influence on hemoglobin levels in alpha-thalassemia and microcytosis. (2/429)

Plasmodium falciparum malaria, alpha-thalassemia, and anemia are frequent in African children. In 494 nonhospitalized Nigerian children, P. falciparum infection rates, alpha-globin genotypes, and hematologic parameters were determined. P. falciparum infection was observed in 78% of the children. The gene frequency of alpha-thalassemia was 0.28. Infection rates and parasitemia were similar for the 3 alpha-globin genotypes. In contrast to nonthalassemic and heterozygous persons, infection in children with homozygous alpha-thalassemia did not influence hemoglobin values. Because microcytosis and anemia are common features of alpha-thalassemia, their significance in P. falciparum infection was examined. Microcytosis was significantly associated with protection from hemoglobin decrease due to P. falciparum. Moreover, the rate of infection was lower in microcytic than in normocytic anemia.  (+info)

Dimethyl adipimidate: a new antisickling agent. (3/429)

A new approach to the prevention of sickling in vitro by use of the bifunctional crosslinking reagent, dimethyl adipimidate, is described. Prior treatment of sickle erythrocytes with dimethyl adipimidate will inhibit sickling in completely deoxygenated erythrocytes. Treated erythrocytes do not demonstrate the potassium loss and viscosity increase that usually accompany sickling. The oxygen affinity of hemoglobin in these cells is increased independently from changes in the concentration of 2,3-diphosphoglycerate. The hemoglobin obtained from treated erythrocytes contains a high-molecular-weight component as well as additional positively charged components. The relative degree to which chemical modification and/or crosslinking is an essential part of the antisickling properties of the material is not known.  (+info)

Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS1652. (4/429)

A low cation conductance and a high anion conductance are characteristic of normal erythrocytes. In sickle cell anemia, the polymerization of hemoglobin S (HbS) under conditions of low oxygen tension is preceded by an increase in cation conductance. This increase in conductance is mediated in part through Ca(++)-activated K(+) channels. A net efflux of potassium chloride (KCl) leads to a decrease in intracellular volume, which in turn increases the rate of HbS polymerization. Treatments minimizing the passive transport of ions and solvent to prevent such volume depletion might include inhibitors targeting either the Ca(++)-activated K(+) channel or the anion conductance. NS1652 is an anion conductance inhibitor that has recently been developed. In vitro application of this compound lowers the net KCl loss from deoxygenated sickle cells from about 12 mmol/L cells/h to about 4 mmol/L cells/h, a value similar to that observed in oxygenated cells. Experiments performed in mice demonstrate that NS1652 is well tolerated and decreases red cell anion conductance in vivo. (Blood. 2000;95:1842-1848)  (+info)

Dichloromethane as an antisickling agent in sickle cell hemoglobin. (5/429)

Microscopic studies of red cells from homozygous sickle cell patients show that dichloromethane does prevent sickle cell formation in vitro and does cause reversion of sickled cells to normal after exposure to dichloromethane. X-ray structural analysis of human deoxyhemoglobin crystals exposed to dichloromethane shows four unique binding sites. Arguments are presented to suggest that the binding site close to tryptophan 14alpha prevents the formation of helical polymers, i.e., prevent sickling.  (+info)

Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution. (6/429)

BACKGROUND: The peroxiredoxins (Prxs) are an emerging family of multifunctional enzymes that exhibit peroxidase activity in vitro, and in vivo participate in a range of cellular processes known to be sensitive to reactive oxygen species. Thioredoxin peroxidase B (TPx-B), a 2-Cys type II Prx from erythrocytes, promotes potassium efflux and down-regulates apoptosis and the recruitment of monocytes by endothelial tissue. RESULTS: The crystal structure of human decameric TPx-B purified from erythrocytes has been determined to 1.7 [corrected)] A resolution. The structure is a toroid comprising five dimers linked end-on through predominantly hydrophobic interactions, and is proposed to represent an intermediate in the in vivo reaction cycle. In the crystal structure, Cys51, the site of peroxide reduction, is oxidised to cysteine sulphinic acid. The residue Cys172, lies approximately 10 A away from Cys51 [corrected]. CONCLUSIONS: The oxidation of Cys51 appears to have trapped the structure into a stable decamer, as confirmed by sedimentation analysis. A comparison with two previously reported dimeric Prx structures reveals that the catalytic cycle of 2-Cys Prx requires significant conformational changes that include the unwinding of the active-site helix and the movement of four loops. It is proposed that the stable decamer forms in vivo under conditions of oxidative stress. Similar decameric structures of TPx-B have been observed by electron microscopy, which show the protein associated with the erythrocyte membrane.  (+info)

Pleiotropic syndrome of dehydrated hereditary stomatocytosis, pseudohyperkalemia, and perinatal edema maps to 16q23-q24. (7/429)

Dehydrated hereditary stomatocytosis (DHS) is a rare genetic disorder of red cell permeability to cations, leading to a well-compensated hemolytic anemia. DHS was shown previously to be associated in some families with a particular form of perinatal edema, which resolves in the weeks following birth and, in addition, with pseudohyperkalemia in one kindred. The latter condition was hitherto regarded as the separate entity, "familial pseudohyperkalemia." DHS and familial pseudohyperkalemia are thought to stem from the same gene, mapping to 16q23-q24. This study screened 8 French and 2 American families with DHS. DHS appeared to be part of a pleiotropic syndrome in some families: DHS + perinatal edema, DHS + pseudohyperkalemia, or DHS + perinatal edema + pseudohyperkalemia. If adequately attended to, the perinatal edema resolved spontaneously after birth. Logistic regression showed that increased mean corpuscular volume and mean corpuscular hemoglobin concentration were the parameters best related to DHS. In patients in whom cation fluxes were investigated, the temperature dependence of the monovalent cation leak exhibited comparable curves. Specific recombination events consistently suggested that the responsible gene lies between markers D16S402 and D16S3037 (16q23-q24). The 95% confidence limits (Z(max) >/= 3.02) spanned almost the complete 9-cM interval between these 2 markers.  (+info)

ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. (8/429)

ICL670A (formerly CGP 72 670) or 4-[3,5-bis-(hydroxyphenyl)-1,2,4-triazol-1-yl]- benzoic acid is a tridentate iron-selective synthetic chelator of the bis-hydroxyphenyl-triazole class of compounds. The present studies used selective radioiron probes of hepatocellular and reticuloendothelial (RE) iron stores in hypertransfused rats and iron-loaded heart cells to define the source of iron chelated in vivo by ICL670A and its mode of excretion, to examine its ability to remove iron directly from iron-loaded myocardial cells, and to examine its ability to interact with other chelators through a possible additive or synergistic effect. Results indicate that ICL670A given orally is 4 to 5 times more effective than parenteral deferoxamine (DFO) in promoting the excretion of chelatable iron from hepatocellular iron stores. The pattern of iron excretion produced by ICL670A is quite different from that of DFO and all iron excretion is restricted to the bile regardless of whether it is derived from RE or hepatocellular iron stores. Studies in heart cell cultures have shown a favorable interaction between DFO and ICL670A manifested in improved chelating efficiency of ICL670A, which is most probably explained by an exchange of chelated iron between ICL670A and DFO. These unique chelating properties of ICL670A may have practical implications for current efforts to design better therapeutic strategies for the management of transfusional iron overload.  (+info)

Discoid red blood cells (RBCs) deposited irreversibly on a horizontal glass surface are studied by means of optical microscopy and image analysis. The relative surface covered by the RBCs, as well as the variance of this surface coverage as a functio
Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion.
Sickle Erythrocytes , The band 3 molecule is an anion channel for bicarbonate in the erythrocyteâ s membrane that assumes a different role in sene..
I was listening to a portable radio today which is powered by 4 AA cells. After a few minutes the radio went silent and I thought the cells might be weak. I dec
The Myopia may develop in eyes that may focus the images in front of the retina instead of being in the retina, which may results in blurred vision.This may also occurs when the eyeball becomes too long and may prevents the incoming light from focusing directly on the retina.It may also be caused by an abnormal shape of the cornea or lens ...
A normal RBC is 6.7-7.8 µm in diameter, approximately the same size as the nucleus of a small lymphocyte, which is often used as a guideline when determining the size of the red cells on a slide. Notice that most of the red cells in this field are about the same size as the nucleus of the lymphocyte shown in the image.. ...
The deoxygenation of alcohols via p-toluic acid esters under single-electron reduction conditions is known as the Marko-Lam deoxygenation.. It has advantages over the Barton-McCombie deoxygenation, including higher stability of the precursors, faster and milder reaction conditions, and unnecessity of toxic (and difficult to remove) organic tin reagents.. ...
TY - JOUR. T1 - Sickle red cell calcium metabolism. T2 - Studies on Ca2+‐Mg2+ATPase and ca‐binding properties of sickle red cell membranes. AU - Litosch, Irene. AU - Lee, Kwang Soo. PY - 1980/6. Y1 - 1980/6. N2 - Sickle (Hb SS) red cells, preloaded with 45Ca by reversal of hemolysis, exhibit an incomplete 45Ca extrusion, retaining approximately four times more 45Ca than normal cells. Studies indicated that neither the reduction in Hb SS cell Ca2+-Mg2+ ATPase activity (84% of normal) nor the activation of Ca2+ -Mg2+ ATPase by calmodulin was sufficiently different from normal cells to attribute a major role to the calcium pump in 45Ca retention. These results suggested that 45Ca retention may reflect an alteration in the calcium-binding properties of Hb SS cell membranes. Low-affinity calcium- binding (freely dissociable) was similar in normal and Hb SS cell membranes. However, the total calcium bound with high-affinity (tightly bound) was four-to-five times greater in Hb SS cell membranes ...
Sickle cell disease is an autosomal recessive genetic red cell disorder with a worldwide distribution. Growing evidence suggests a possible involvement of complement activation in the severity of clinical complications of sickle cell disease. In this study we found activation of the alternative complement pathway with microvascular deposition of C5b-9 on skin biopsies from patients with sickle cell disease. There was also deposition of C3b on sickle red cell membranes, which is promoted locally by the exposure of phosphatidylserine. In addition, we showed for the first time a peculiar stop-and-go motion of sickle cell red blood cells on tumor factor-α-activated vascular endothelial surfaces. Using the C3b/iC3b binding plasma protein factor Has an inhibitor of C3b cell-cell interactions, we found that factor H and its domains 19-20 prevent the adhesion of sickle red cells to the endothelium, normalizing speed transition times of red cells. We documented that factor H acts by preventing the ...
Vaso-occlusive pain episodes in sickle cell anemia are hypothesized to be precipitated by adherence of sickle erythrocytes to vascular endothelium in the microcirculation. Febrile episodes, thought to be viral in etiology, are frequently associated with vaso-occlusion; however, a direct link between viral infection and vascular occlusion has not yet been established. Many pathogenic viruses contain double-stranded RNA or replicate through double- stranded RNA intermediates. Double-stranded RNA has been shown to induce vascular cell adhesion molecule-1 (VCAM-1) protein expression on endothelial cells. Recently, a new adhesion pathway has been described between VCAM-1 expressed on cytokine stimulated endothelium and the α4β1 integrin complex expressed on sickle reticulocytes. Based on these observations, the hypothesis was developed that vital infection, through double-stranded RNA intermediates, increases endothelial VCAM-1 expression leading to sickle erythrocyte adhesion to endothelium via an ...
The 2019 Point-in-Time (PIT) Count is fast approaching. To help prepare Continuums of Care (CoCs) for the 2019 PIT count, and address any other questions CoCs have about the PIT count, HUD is hosting its next PIT count office hours on October 30, 2018 from 1:30 to 3:00 PM EDT. HUD will start the call with a discussion of the 2019 Housing Inventory Count (HIC) and PIT count changes and will also discuss issues around PIT count volunteers, including recruitment, training, and waivers.. Note that HUD will not be conducting a separate webinar for the 2019 HIC and PIT Count Notice. HUD anticipates conducting one more office hours session preceding the 2019 PIT count.. Register for the October 30 PIT count office hours.. ...
BACKGROUND: Sickle cell disease is an autosomal recessive inherited haemoglobinopathy which causes painful vaso-occlusive crises due to sickle red blood cell dehydration. Vaso-occlusive crises are common painful events responsible for a variety of clinical complications; overall mortality is increased and life expectancy decreased compared to the general population. Experimental studies suggest that intravenous magnesium has proven to be well-tolerated in individuals hospitalised for the immediate relief of acute (sudden onset) painful crisis and has the potential to decrease the length of hospital stay. Some in vitro studies and open studies of long-term oral magnesium showed promising effect on pain relief but failed to show its efficacy. The studies show that oral magnesium therapy may prevent sickle red blood cell dehydration and prevent recurrent painful episodes. There is a need to access evidence for the impact of oral and intravenous magnesium effect on frequency of pain, length of ...
Under venular flow conditions, sickle cell adherence to endothelium is mediated by cell adhesion molecules and adhesive proteins associated with inflammation, coagulation, and endothelial perturbation. Periodic and reduced blood flow are observed in sickle microcirculation during hematologic steady state, suggesting that blood flow is compromised in sickle microcirculation. We tested the hypothesis that low blood flow enhances adherence by quantifying sickle cell adhesion to endothelium under venular flow (1.0 dyne/cm2 shear stress) and low flow (0.1 dyne/cm2 shear stress), with and without addition of adhesion promoting agonists. Under low flow, sickle cell adherence to endothelium increases with contact time in the absence of endothelial activation or adhesive protein addition. In contrast, at venular shear stress, sickle cell adherence only occurs following endothelial activation with TNF-α or addition of thrombospondin. Analysis of these data with a mathematical model reveals that at low ...
TY - JOUR. T1 - Activated monocytes in sickle cell disease. T2 - Potential role in the activation of vascular endothelium and vaso-occlusion. AU - Belcher, J. D.. AU - Marker, P. H.. AU - Weber, J. P.. AU - Hebbel, R. P.. AU - Vercellotti, G. M.. PY - 2000/10/1. Y1 - 2000/10/1. N2 - Sickle cell anemia is characterized by painful vaso-occlusive crises. It is hypothesized that monocytes are activated in sickle cell disease and can enhance vaso-occlusion by activating endothelium. To test this hypothesis, human umbilical vein endothelial cells (HUVEC) and human microvascular endothelial cells (MVEC) with sickle and normal mononuclear leukocytes were incubated, and endothelial activation was measured. Endothelial cells incubated with sickle mononuclear leukocytes were more activated than those incubated with normal mononuclear leukocytes, as judged by the increased endothelial expression of adhesion molecules and tissue factor and the adhesion of polymorphonuclear leukocytes (PMNL). Monocytes, not ...
The |i|Journal of Biomedical Optics|/i| (JBO) publishes peer-reviewed papers on the use of modern optical technology for improved health care and research.
Microcytic anemia is not caused by reduced DNA synthesis[citation needed].. Thalassemia can cause microcytosis. Depending upon how the terms are being defined, thalassemia can be considered a cause of microcytic anemia, or it can be considered a cause of microcytosis but not a cause of microcytic anemia.. There are many causes of microcytosis, which is essentially only a descriptor. Cells can be small because of mutations in the formation of blood cells (hereditary microcytosis) or because they are not filled with enough hemoglobin, as in iron-deficiency-associated microcytosis.. Red blood cells can be characterised by their haemoglobin content as well as by their size. The haemoglobin content is referred to as the cells colour. Therefore, there are both normochromic microcytotic red cells and hypochromic, microcytotic red cells. The normochromic cells have a normal concentration of haemoglobin, and are therefore red enough while the hypochromic cells do not; thus the value of the mean ...
Sickle cell disease (SCD) is the most common genetic disease in the United States inherited as an autosomal recessive disorder, where approximately 70,000 individuals have sickle cell disease. Acute painful vaso-occlusive crisis (VOCs) is one of the common complications of SCD that influences overall survival (Platt, Thorington et al. 1991). Pain, is also the most common cause of SCD morbidity, which has a negative impact on quality of life of these individuals and their families. There is significant inter-individual variation in the frequency and course of severe VOCs that result in hospital based treatment, the reasons for which have not been clearly elucidated. Vaso-occlusion of irreversibly sickle red cells within the microcirculation is believed to be the proximate cause of painful VOCs, however it is likely that other non-SCD related factors affecting pain perception and sensitivity to pain will also contribute to individuals susceptibility to pain and therefore contribute to the observed ...
Sickle cell disease (SCD) is the most common genetic disease in the United States inherited as an autosomal recessive disorder, where approximately 70,000 individuals have sickle cell disease. Acute painful vaso-occlusive crisis (VOCs) is one of the common complications of SCD that influences overall survival (Platt, Thorington et al. 1991). Pain, is also the most common cause of SCD morbidity, which has a negative impact on quality of life of these individuals and their families. There is significant inter-individual variation in the frequency and course of severe VOCs that result in hospital based treatment, the reasons for which have not been clearly elucidated. Vaso-occlusion of irreversibly sickle red cells within the microcirculation is believed to be the proximate cause of painful VOCs, however it is likely that other non-SCD related factors affecting pain perception and sensitivity to pain will also contribute to individuals susceptibility to pain and therefore contribute to the observed ...
Most common are the signs of anemia - fatigue, dizziness, headache, shortness of breath and cold hands and feet. Sickle cell disease has multiple complications. In the hand-foot syndrome, the sickle red blood cells block the small blood vessels of the hands and feet, causing pain, swelling and fever. Infections, such as pneumonia or the flu, are common. People with sickle cell disease are at higher risk for stroke, damage to the retina of the eye, development of gallstones, leg ulcers and delayed growth in children ...
Find information about vaso-occlusion and the associated risks that may occur even when its effects are not always seen in VOC/pain crises.
On the other hand when very similar in vivo experimental assessments are operate on sickle-mobile hemoglobin in whole purple blood cells, the procedure was only reversible around a specific duration of exposure time. After several several hours, the process could no longer be reversed. The explanations for this relate back to our before question of what was the exact outcome with the mutation around the crimson blood mobile and its contents. Each time a extensive-term sickled cell is broken open along with a ghost geared up, Despite having the hemoglobin extracted, additional hints the mobile retains its sickled condition. In-Textual content Issue 5: What could you hypothesize to get the cause of this phenomenon and how wouldnt it relate to the sooner conclusion that hemoglobin, not other mobile parts, are the internet site in the mutations result? In-Textual content Reply five The notion that sickle mobile anemia results from a specific amino acid substitution within a polypeptide was ...
Key Points. Sickle RBC ROS production is mediated in part by NADPH oxidase activity.Sickle RBC ROS production can be induced by plasma signaling molecules.
When adequately prepared and examined microscopically by an experienced technologist and pathologist, a Smear of Peripheral Blood is the most informative of all hematologic tests. All three hematologic cell lines-erythrocytes (Red Blood Cells), platelets, and leukocytes (White Blood Cells)-can be examined. In the peripheral blood, five different types of leukocytes can routinely be identified-neutrophils, eosinophils, basophils, lymphocytes, and monocytes. The first three are also referred to as Granulocytes.. Microscopic examination of the Red Blood Cells can reveal variations in RBC size (anisocytosis), shape (poikilocytosis), color, or intracellular content. Classification of RBCs according to these variables is most helpful in identifying the causes of anemia and the presence of other diseases. The following are the possible causes of abnormality that can seen microscopically on Red Blood Cells:. ...
Found during a carcass inspection on a Muntjac taken last week. Noticed Kidney was an abnormal shape and firm to feel. On further inspection discovered a cyst filled with a clear liquid with white flecks inside. No other abnormalities found. It was an older Buck (6+ years old at a guess). In good shape other than the effect a well placed bullet creates so no qualms about putting into the food chain. I am presuming a parasite of some kind. Had a look at some other posts on Kidney abnormalities
Does anyone know of a company that cells gradient seperation material made of arabinogalactan or stractan that comes pre-made in physiologic saline. I have a product called CelSep that Larex no longer sells and I am looking for a company that might sell something similar. My goal is to separate red cells specifically for reticulocyte enrichment. Christine Ponte, M.S. Dept. of Medicine/Division of Hematology/Cardeza 1015 Walnut St., Room 702 Phila. PA, 10107 215-955-1529 office, 215-955-2256 lab ...
ANISOCITOSIS DEFINICION PDF - Contextual translation of anisocitosis ligera definicion into English. Human translations with examples: slight anisocytosis. ejemplo, frente a una
FWIW, here is my best solution for the 34C: Take a lok in the battery compartment. On the left youll find the two contacts for + and - while on the right hand side there is a small metal plate - if I remember correctly, I may be wrong here. I removed this plate (if there was one ;-)) and replaced it with a piece of aluminum foil, folded several times. This way two standard Sanyo/Panasonic Eneloop AA cells (with standard button top) fit nicely into the compartment. You can do even better if you replace the aluminum foil with something more suitable ...
The main function of RBCs is the transport of oxygen from the lungs to body tissues. All of the cells in this Wright-stained peripheral blood smear are normal RBCs.. ...
Definition of mean corpuscular hemoglobin concentration (MCHC) in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is mean corpuscular hemoglobin concentration (MCHC)? Meaning of mean corpuscular hemoglobin concentration (MCHC) as a finance term. What does mean corpuscular hemoglobin concentration (MCHC) mean in finance?
Book Mean Corpuscular Haemoglobin Concentration (MCHC)-Calculated Lab Test appointment online at Home. View details of Mean Corpuscular Haemoglobin Concentration (MCHC)-Calculated: procedure, normal range and Get the reports Online
Book Mean Corpuscular Haemoglobin Concentration (MCHC)-Calculated Lab Test appointment online at Home. View details of Mean Corpuscular Haemoglobin Concentration (MCHC)-Calculated: procedure, normal range and Get the reports Online
This mean corpuscular hemoglobin concentration (MCHC) calculator determines the concentration of Hb in the erythrocytes as MCHC is one of the RBC indices.
Observations of visual acuity and the conjunctival, macular, and perimacular vascularity have been assessed in patients with homozygous sickle cell (SS) disease. There were 17 matched pairs, each consisting of one patient with a high count (greater than or equal to 15%) and one with a low count (less than or equal to 5%) of irreversibly sickled cells (ISCs). The macular vascular bed was assessed by measurements of the foveal avascular zone (FAZ), perimacular avascular zones, and counts of perimacular vascular abnormalities (perimacular counts). Small foveal avascular zones and high perimacular counts were commoner in younger than older patients and there was a significant inverse correlation between size of the FAZ and the perimacular count. These observations were compatible with the hypothesis that perimacular vessel anomalies represent the early vaso-occlusive phase which progresses to ischaemia and the formation and enlargement of avascular areas. Visual acuity was assessed by Snellens test ...
Bee venom phospholipase A2 and the fluorescent probe merocyanine 540 were used to examine plasma membrane phospholipid organization in the spicules released by deoxygenation and reoxygenation of sickle red cells, as well as in reversibly and irreversibly sickled erythrocytes. Digestion of phosphatidyl ethanolamine in spicules was comparable to that of phosphatidyl choline, and these structures were stained by the fluorescent probe. Both assays suggest that membrane lipid asymmetry is disrupted in spicules. The residual cells, from which the spicules were derived, retain the normal asymmetry in phospholipid distribution between the outer and inner leaflets of the plasma membrane bilayer. Comparable experiments with cell fractions enriched in irreversibly sickled cells revealed a partial enhancement of phosphatidyl ethanolamine digestion, confirming the similar experiments of Lubin et al (1981). Staining of these cells with merocyanine 540, however, did not reveal a subfraction of stainable cells, ...
Red cells that contain primarily HbS or HbS with one of the variants that interacts with it, such as HbC, are abnormal in many respects, including that as a result of hemolysis they are overall much younger than normal erythrocytes.1 The fundamental defect in sickle red blood cells (SS RBCs) is the insolubility of HbS when it becomes deoxygenated, leading to formation of polymers that aggregate into tubular fibers and, as they enlarge, deform red cells, causing the characteristic sickle shape. In addition, SS RBCs become dehydrated, have abnormally activated intracellular signaling pathways, have decreased nitric oxide2 and adenosine triphosphate3 content and antioxidant capacity, demonstrate oxidative damage to many cellular components,4 and reflect dysregulation of miRNAs and gene expression during erythropoiesis.5,6 Cellular dehydration contributes to deoxygenated hemoglobin polymer formation and ultimately cell sickling and hemolysis. Signaling pathways downstream of the β2 adrenergic ...
TY - JOUR. T1 - HO-1 hi patrolling monocytes protect against vaso-occlusion in sickle cell disease AU - Liu, Yunfeng. AU - Jing, Fangmiao. AU - Yi, Woelsung. AU - Mendelson, Avital. AU - Shi, Patricia. AU - Walsh, Ronald. AU - Friedman, David F.. AU - Minniti, Caterina. AU - Manwani, Deepa. AU - Chou, Stella T.. AU - Yazdanbakhsh, Karina. N1 - Funding Information: This study was supported by National Institutes of Health, National Heart, Lung, and Blood Institute (R01HL121415 and R01HL130139) (K.Y.) and American Heart Association (K.Y.). Publisher Copyright: © 2018 by The American Society of Hematology.. PY - 2018/4/5. Y1 - 2018/4/5. N2 - Patients with sickle cell disease (SCD) suffer from intravascular hemolysis associated with vascular injury and dysfunction in mouse models, and painful vaso-occlusive crisis (VOC) involving increased attachment of sickle erythrocytes and activated leukocytes to damaged vascular endothelium. Patrolling monocytes, which normally scavenge damaged cells and ...
Looking for online definition of stomatocytosis in the Medical Dictionary? stomatocytosis explanation free. What is stomatocytosis? Meaning of stomatocytosis medical term. What does stomatocytosis mean?
Severe Hemolytic Anemia Post-Renal Transplantation Produced by Donor Anti-D Passenger Lymphocytes: Case Report and Literature Review Academic Article ...
NICE asks for views on plans to recommend the Spectra Optia Apheresis System which automatically replaces sickle red blood cells with healthy red blood cells
Sickle Cell Anemia Facts tell you about the genetic disease on the red blood cells. In the normal condition, the red blood cells have the disk shape. Therefore, the red bloods cells can travel easily even inside the smallest blood vessels. But the people with the sickle cell anemia have crescent shaped red blood cells. This abnormal shape makes the cells unable to travel in the blood vessel due to the rigid and sticky texture and shape.. ...
To be in the perfect shape, people loans that are intended to be used for plastic and cosmetic surgeries. They may have trouble stopping the bleeding, the scars may be crooked, you may following: Breast Augmentation Both types of breast implants saline and silicone were introduced in the 1960s. Most surgeons will try to hide incision lines in places where they arent noticeable, like under the crease of the breast requires minimal instrumentation and infrastructure but high degree of innovative surgical skill. A well toned firmness of selective areas is achieved by removing any procedure, carries with it some degree of risk. 5 million cosmetic plastic surgery procedures were performed in the United States most patients to fend for themselves when it comes to paying the high cost of looking good. Also very many people never like to be referred as old, they appropriate choice of wound closure, use of Anesthesiologist home loan An Ideas Breakdown On Root Aspects Of Doctor Home Loan Sydney Australia ...
Author: Vereyken, I. J. et al.; Genre: Journal Article; Published in Print: 2003; Keywords: Liposomes. Vitrification. Dehydration. Bilayers. Phase. Membranes.|br/|Stress. Anhydrobiosis. Stability. Tobacco.|br/|Biochemistry & Biophysics in Current Contents(R)/Life Sciences.|br/|2003 week 47; Title: The effect of fructan on the phospholipid organization in the dry state
Moderate hemolytic anemia, abnormal erythrocyte morphology (spherocytosis), and decreased membrane stability are observed in mice with complete deficiency of all erythroid protein 4.1 protein isoforms (4.1(-/-); Shi TS et al. J Clin Invest 103: 331, 1999). We have examined the effects of erythroid protein 4.1 (4.1R) deficiency on erythrocyte cation transport and volume regulation. 4.1(-/-) mice exhibited erythrocyte dehydration that was associated with reduced cellular K and increased Na content. Increased Na permeability was observed in these mice, mostly mediated by Na/H exchange with normal Na-K pump and Na-K-2Cl cotransport activities. The Na/H exchange of 4.1(-/-) erythrocytes was markedly activated by exposure to hypertonic conditions (18.2 +/- 3.2 in 4.1(-/-) vs. 9.8 +/- 1.3 mmol/10(13) cell x h in control mice), with an abnormal dependence on osmolality (EC(50) = 417 +/- 42 in 4.1(-/-) vs. 460 +/- 35 mosmol/kgH(2)O in control mice), suggestive of an upregulated functional state.
Mean corpuscular hemoglobin concentration (MCHC) So youve gone to your doctor and had some blood test done. You are looking over the results wondering why the hell you have low MCHC? Here are some reasons why this can occur. The first reason would be anemia. This is when your body is low on what it…
Mean corpuscular hemoglobin concentration (MCHC) So youve gone to your doctor and had some blood test done. You are looking over the results wondering why the hell you have low MCHC? Here are some reasons why this can occur. The first reason would be anemia. This is when your body is low on what it…
In order to identify new biomarkers to assess the status of patients with sickle cell disease (SCD) we have assembled a team of 5 principal investigators with e...
Acanthocyte, in human biology and medicine, refers to a form of red blood cells with spikes on it. Acanthocytosis is the condition with acanthocyte-like red blood cells.These cells are coarse and irregularly crenellated resembling many-pointed stars.Red cells of normal size are said to be normocytic.Medical Tests Analyzer labtest bloodtest What does the test result mean?
Figure 2: Saline/chamomile e×tract treated group: On day 8, the jejunum shows nearly normal shape of villi (A1, Trichrome ×100), most of the villi seen cover by columnar epithelium, the crypt and the muscular layers appear normal (A2,A3 Trichrome ×400), or sometimes the epithelium of villi are missing with cellular infiltration in the lamina propria (A4, Trichrome ×400). On day 12, the villi appear with abnormal shape (B1, Trichrome ×40), the tips of some villi shows necrosis (upper arrow) with inflammatory cell infiltration in the lamina propria, lower arrow (B2,H&E ×400). Congested blood vessels in the lamina propria, arrow (B3, Trichrome ×400) with muscular edema are also seen, arrow (B4,H&E ×400). Mild and negative Ki-67 immuno reactivity in nuclei of cells at day eight and twelve respectively (C1, immunohistochemistry ×400, C2, immunohistochemistry ×400). Moderate and negative cytoplasmic reaction to Bcl-2 cells at day eight and twelve respectively (C3 immunohistochemistry ×400, ...
Craniosynostosis is a birth defect in which the bones of the skull prematurely fuse. This causes skull to develop an abnormal shape and can cause cognitive issues if severe enough. Interventions include either endoscopic or open surgery. Why would you choose one over the other?
Have you been told that you may have keratoconus? Dr. Susan Johnson would be happy to explain in detail. Keratoconus is a vision disorder that occurs when the normally round cornea (the front part of the eye) becomes thin and irregular (cone) shaped. This abnormal shape prevents the light entering the eye from being focused…
Short story - only about 320mA/h capacity each!!! Details; I have a flashlight sku.7503 that can take either two AA cells by using an extender tube or a single Li-Ion cell. Ive used it for years with two AAs. Then I was given an old Canon battery... Short story - only about 320mA/h capacity each!!! Details; I have a flashlight sku.7503 that can take either two AA cells by using an extender tube or a single Li-Ion cell. Ive used it for years with two AAs. Then I was given an old Canon battery pack from a dead camera. I opened it and found it had two Sony 14430 cells that were originally rated at 580mA/h. I tested them and was very pleased to find that after 5 years they still held over 400mA/h each and started using them in my flashlight. Then I thought it would be nice to have cells that lasted longer so I ordered two packs of these. At 900mA/h they should last twice as long as my recycled Sony cells... After I received my new 900mA/h cells I connected them up to my regular Li-Ion charging / ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015 ...
Ektacytometry was performed on RBC from the patient and his parents. Whole blood was mixed with isotonic buffer containing either Na+ or K+ ions and freed of white cells at room temperature. The suspensions were kept on ice, sequentially centrifuged and subjected to ektacytometry (1 h to 2 h) (Figure 1A). The osmoscans of both parents were super-imposable whether cells were pre-incubated with Na+- or K+-containing buffer. While the osmoscans of RBC from the mother (BN, BK) displayed a nearly normal pattern [see the corresponding control scan (con)], the two osmoscans from his fathers RBC (CN, CK) showed a left shift, implying a higher surface/volume ratio than normally observed, indicative of macrocytosis. The osmoscans from the patients RBC differed considerably from those of his parents and varied depending on the cation composition of the buffer (Figure 1A: AN, AK). When kept in Na+-containing buffer (AN), the RBC revealed a pattern similar to that seen for RBC from patients with hereditary ...
Liver: 90 - 95% of the tissue is replaced by a poorly demarcated, non encapsulated, infiltrative, multilobulated and densely cellular mass with small groups of remaining hepatocytes. Neoplastic cells are closely packed, supported by scant amount of fibrovascular stroma and arranged in anastomosing cords, islands and sheets. The neoplastic cells are polygonal to spindleoid, 15 to 30 μm in size with indistinct cell borders and have a high amount of granular eosinophilic cytoplasm and often contain birefringent olive-green to golden-brown granular pigment within the cytoplasm. Nuclei are round to oval to irregular with finely stippled chromatin and have up to three prominent nucleoli. Many cells contain up to five oval to irregular nuclei or have a huge nucleus (megakaryosis). Anisocytosis and anisokaryosis are high and there is anaplasia of neoplastic cells. In 10 HPF there are nine mitotic figures, some of which are bizarre. There are multifocal randomly distributed areas of necrosis, ...
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. Found 593 words containing cyto. Pathology → cytopathology. The prefix cyto- means the word is related to the cell. [G. kytos, a hollow (cell)] Found 248 words that start with cyto. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. It comes from the Greek kytos, meaning hollow receptacle. Cyto- definition: indicating a cell , Meaning, pronunciation, translations and examples cyto-: , cyt- ( sītō, sīt ), Do not confuse this combining form with sito- . cyto-, cyt-, -cyte, cytio- (Greek: cells, cell, hollow; used primarily in the extended sense of animal or plant cells [because cells were originally thought to be hollow]) anisocytosis Considerable variation in the size of cells that are normally uniform, ...
Many years ago, an old engineer gave me a valuable piece of advice, suggesting that a common mistake we make in trying to make our designs foolproof is to underestimate the ingenuity of fools. One of the simplest things we can do to thwart those ingenious fools is to prevent the power to our circuit being connected the wrong way. Id recommend you consider this for all your designs even if there is only the most remote possibility that a reverse polarity could occur.. Lets say we have a circuit powered by 2 AA cells that draws up to 100mA and operates over the 3.0V to 2.0V range, which is about what we can expect over the batterys useful life. Our circuit cant tolerate a reverse connection of the batteries so we can be assured that sooner or later someone will do exactly that. How can we protect the circuit?. The simplest approach is to add a diode in series with your power supply. As shown at left in Figure 1 below. This works well but there will be a forward voltage drop across the diode of ...
Futaba 2HR ideal for use on Tamiya and other R/C cars, Servo is not included. requires 4 x AA Cell batteries.The new Futaba 2HR radio is designed for those car, boat and glider modellers that need a high quality yet affordable 2 channel 2.4GHz system, and includes steering dual rates, servo reversin ...
Shortman, BCRP protein levels are lower in CA or AA cells than in CC cells. There are different perspectives on the effectiveness of omega-3 fatty acids in the treatment of schizophrenia. r0Fpфё.
Here is another possibility. My inventory notes that one of my 2550IIIs has a nine volt connector soldered to the battery pack connector. I cant tell you about polarity at this time. I expect to go to my winter home in a week or so. I can look at the unit then and tell you what I see.. The idea of wiring in a nine volt connector is similar in concept to what users did with the TI-55. It used nine volts generated by a battery pack, but the connector was different. There were several battery packs of that general design -- the BP-7 and BP-8, for example. They used two NiCad AA cells and a circuit board to convert the output from the cells to a nine volt output. Finding one that works is not so easy these days. If the cells leak the circuit board was typically damaged beyond repair ...
Angle, C. R.; Swanson, M. S.; Stohs, S. J.; Markin, R. S. (1985). "Abnormal erythrocyte pyrimidine nucleotides in uremic ... Angle, C. R.; Stohs, S. J.; McIntire, M. S.; Swanson, M. S.; Rovang, K. S. (1980). "Lead-induced accumulation of erythrocyte ... Angle, C. R.; McIntire, M. S.; Swanson, M. S.; Stohs, S. J. (1982). "Erythrocyte nucleotides in children--increased blood lead ... Angle, C. R.; Kuntzelman, D. R. (1989). "Increased erythrocyte protoporphyrins and blood lead-a pilot study of childhood growth ...
"Erythrocyte echinocytosis in liver disease. Role of abnormal plasma high density lipoproteins". Journal of Clinical ... Jeican, II; Matei, H; Istrate, A; Mironescu, E; Bâlici, S (April 2017). "Changes observed in erythrocyte cells exposed to an ... refers to a form of red blood cell that has an abnormal cell membrane characterized by many small, evenly spaced thorny ... "Electric field pulses induce reversible shape transformation of human erythrocytes". Mol Membr Biol. 14: 195-204. doi:10.3109/ ...
Rijksen, G; Staal, G E. (August 1978). "Human erythrocyte hexokinase deficiency. Characterization of a mutant enzyme with ... abnormal regulatory properties". J. Clin. Invest. 62 (2): 294-301. doi:10.1172/JCI109129. PMC 371766. PMID 27532. Wilson, ... and erythrocytes, the major components of blood and the bone marrow. An anemia is a decrease in number of red blood cells (RBCs ...
The abnormal erythrocytes are sphere-shaped (spherocytosis) rather than the normal biconcave disk shaped. Dysfunctional ... This shortage of erythrocytes results in hemolytic anemia. It was first described in 1871. It is the most common cause of ... The disorder is caused by mutations in genes relating to membrane proteins that allow for the erythrocytes to change shape. ... Hereditary spherocytosis is an abnormality of red blood cells, or erythrocytes. A chronic disease with a long term health ...
Theodor Boveri originally observed the fact that abnormal nuclear morphologies commonly occur in cancer. Micronuclei are also ... referred to Howell-Jolly bodies; discovered by hematologists William Henry Howell and Justin Marie Jolly in erythrocytes. ... The formation of an abnormal nuclear structure called chromosome bridge also predisposes to micronucleation. Bridges arise from ...
Liver enzymes are abnormal in half of the patients, with mild elevation of AST. The erythrocyte sedimentation rate and C- ...
Cardiac manifestations include life-threatening conditions such as cardiogenic shock or sudden death due to abnormal heart ... These include elevations in blood markers for systemic inflammation (e.g. C reactive protein, erythrocyte sedimentation rate) ... and cardiac injury (e.g. creatine kinase, troponins); and abnormal electrocardiograms ( mostly ST segment-T wave abnormalities ... supporting cardiac function by relieving heart failure and suppressing life-threatening abnormal heart rhythms; b) suppressing ...
"Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria". Nature. 435 (7045): 1117-1121 ... "Abnormal PfEMP1/knob display on Plasmodium falciparum-infected erythrocytes containing hemoglobin variants: fresh insights into ... Hemoglobin c (abbreviated as HbC) is an abnormal hemoglobin in which glutamic acid residue at the 6th position of the β-globin ... Genetically, the abnormal hemoglobin was only in heterozygous condition. The next year, Neel and his colleagues established ...
The mechanisms by which erythrocytes containing abnormal hemoglobins, or are G6PD deficient, are partially protected against P ... "Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria" (PDF). Nature. 435 (7045): 1117 ... SAO is caused by a mutation in the gene encoding the erythrocyte band 3 protein. There is a deletion of codons 400-408 in the ... Jarolim P, Palek J, Amato D, Hassan K, Sapak P, Nurse GT, Rubin HL, Zhai S, Sahr KE, Liu SC (1991). "Deletion in erythrocyte ...
These include elevations in blood markers for systemic inflammation (e.g. C reactive protein, erythrocyte sedimentation rate), ... These findings suggest that eosinophilic myocarditis is caused by the abnormal proliferation and activation of eosinophils and ... elevations in blood markers for cardiac injury (e.g. creatine kinase, troponins); and abnormal electrocardiograms ( mostly ST ... supporting cardiac function by relieving heart failure and suppressing life-threatening abnormal heart rhythms; b) suppressing ...
The mechanisms by which erythrocytes containing abnormal hemoglobins, or are G6PD deficient, are partially protected against P ... "Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria" (PDF). Nature. 435 (7045): 1117 ... Other erythrocyte mutations[edit]. Other genetic mutations besides hemoglobin abnormalities that confer resistance to Plasmodia ... Other rare erythrocyte mutations[edit]. See also: GYPA, GYPB, and MNS antigen system ...
C-reactive protein and the erythrocyte sedimentation rate) are typically elevated, and abnormal liver enzymes may be seen. If ...
If splenic macrophage function is abnormal or absent because of splenectomy, altered erythrocytes will not be removed from the ... which may cause an abnormal decrease in cell volume without affecting the amount of membrane area). The increase in the surface ...
G substitutions at codon 164 caused severe erythrocyte ADK deficiency. Two siblings had erythrocyte ADK deficiency, but one did ... In another patient, an abnormal fragment with homozygous and heterozygous A--> ... Abrusci P, Chiarelli LR, Galizzi A, Fermo E, Bianchi P, Zanella A, Valentini G (August 2007). "Erythrocyte adenylate kinase ... Qualtieri, A.; Pedace, V.; Bisconte, MG.; Bria, M.; Gulino, B.; Andreoli, V.; Brancati, C. (Dec 1997). "Severe erythrocyte ...
... its role in binding of autoantibodies against band 3 to abnormal and aged erythrocytes". Proc. Natl. Acad. Sci. U.S.A. 83 (16 ... The erythrocyte and kidney forms are different isoforms of the same protein. The erythrocyte isoform of AE1, known as eAE1, is ... Jarolim P, Palek J, Amato D, Hassan K, Sapak P, Nurse GT, Rubin HL, Zhai S, Sahr KE, Liu SC (1991). "Deletion in erythrocyte ... In mammals, it is present in two specific sites: the erythrocyte (red blood cell) cell membrane and the basolateral surface of ...
This includes a full blood count, clotting status (PT, aPTT, TT), and some screening tests (erythrocyte sedimentation rate, ... kidney function, liver enzymes, electrolytes). If one of these is abnormal, further investigations might be warranted to the ... a prospective multicenter cohort study of consecutive patients with abnormal perfusion scintigraphy". Journal of Thrombosis and ...
It is a subtype of basophilic granules of the erythrocyte, but which can only be seen in bone marrow. To count a cell as a ring ... Microscopic viewing of the red blood cells will reveal marked unequal cell size and abnormal cell shape. Basophilic stippling ... Normally, sideroblasts are present in the bone marrow, and enter the circulation after maturing into a normal erythrocyte. The ... In excess of 40% of the developing erythrocytes are ringed sideroblasts. Serum iron, percentage saturation and ferritin are ...
Abnormal heart rate characteristics (HRC) of transient decelerations and reduced baseline variability in heart rate are a risk ... micro ESR (erythrocyte sedimentation rate) titer > 15mm. gastric aspirate showing > 5 polymorphs per high power field. newborn ... "Abnormal heart rate characteristics preceding neonatal sepsis and sepsis-like illness". Pediatric Research. 53 (6): 920-926. ...
Creatinine is occasionally elevated and electrolytes are occasionally abnormal. A high blood calcium level is noted in ... Chemistry tests include lactate dehydrogenase (LDH) levels, uric acid levels, erythrocyte sedimentation rate (ESR), kidney and ...
Liver and kidney function tests are often abnormal.[citation needed] Thrombosis of the internal jugular vein can be displayed ... erythrocyte sedimentation rate and white blood cells (notably neutrophils). Platelet count can be low or high. ...
... the reduction of mutant JAK2 concentrations by givinostat is believed to slow down the abnormal growth of erythrocytes and ...
This is abnormal and provides evidence that increased erythrocyte dATP levels are the toxic metabolites responsible for immune ... Infusion of normal, non-enzyme deficient erythrocytes resulted in the loss of dATP in the erythrocytes of these individuals. ... "Deoxyadenosine triphosphate acting as an energy-transferring molecule in adenosine deaminase inhibited human erythrocytes". ... immunodeficient and adenosine deaminase deficient were found to have over 50 times the levels of dATP in their erythrocytes ...
No abnormal clinical signs were observed. In rabbits methiocarb was applied to the skin to a group of ten at doses of 0, 60, ... The erythrocyte acetylcholinesterase activity is apparently not inhibited in a dose-related fashion. The duration of the study ...
Where these branched tumor-associated endothelial cells form small gaps in the blood vessel wall, erythrocytes often pool and ... It has been suggested that these flow-mediated changes cause abnormal expression of transcription factors which promotes ... Tumor endothelial cells (TECs) have been documented to demonstrate abnormal morphologic characteristics such as ragged margins ... and its receptor on endothelial cells are molecular-level changes that can account for this abnormal loss in pericyte support. ...
While the white blood cell count, erythrocyte sedimentation rate, and C-reactive protein tests may be abnormal and there may be ...
... erythrocyte membrane MeSH A11.118.290.330 - erythrocytes, abnormal MeSH A11.118.290.330.100 - acanthocytes MeSH A11.118.290.330 ... erythrocytes, abnormal MeSH A11.443.240.330.100 - acanthocytes MeSH A11.443.240.330.531 - megaloblasts MeSH A11.443.240.330.802 ... erythrocyte inclusions MeSH A11.284.420.204.335 - heinz bodies MeSH A11.284.420.390 - inclusion bodies, viral MeSH A11.284. ... erythrocyte inclusions MeSH A11.118.290.330.315.335 - heinz bodies MeSH A11.118.290.330.531 - megaloblasts MeSH A11.118.290.330 ...
... recessive form of hemolytic anemia characterized by an abnormal sensitivity of red blood cells to heat and erythrocyte ... HPP has been associated with a defect of the erythrocyte membrane protein spectrin and with spectrin deficiency. It was ... Splenectomy is a possible treatment[citation needed] Erythrocyte Poikilocytosis List of hematologic conditions " ... "A congenital haemolytic anaemia with thermal sensitivity of the erythrocyte membrane". Br J Haematol. 29 (4): 537-43. doi: ...
... erythrocyte membrane MeSH A15.145.229.334.330 - erythrocytes, abnormal MeSH A15.145.229.334.330.100 - acanthocytes MeSH A15.145 ... MeSH A15.145.229.188 - blood platelets MeSH A15.145.229.334 - erythrocytes MeSH A15.145.229.334.270 - ... 330.340 - erythrocyte inclusions MeSH A15.145.229.334.330.340.335 - heinz bodies MeSH A15.145.229.334.330.531 - megaloblasts ...
... in which erythrocytes are destroyed before being released from the bone marrow. Abnormal hemoglobin precipitation Heinz bodies ... Cabot rings - ring-like structure and may appear in erythrocytes in megaloblastic anemia or in severe anemias, lead poisoning, ... Hemoglobin H inclusions - alpha thalassemia, greenish-blue inclusion bodies appear in many erythrocytes after four drops of ... dark-staining granules that appear near the periphery of a young erythrocyte in a Wright stain. Polychromatophilic red cells - ...
Red blood cells (erythrocytes) from donors contain normal hemoglobin (HbA), and transfusion of normal red blood cells into ... ultrasonography shows abnormal increased cerebral blood flow velocities. In those who have sustained a prior stoke event it ... people with sickle cell disease reduces the percentage of red cells in the circulation containing the abnormal hemoglobin (HbS ...
ICAM-4 and CD36 are implicated in the abnormal adhesiveness to endothelium of sickle cell SAD mouse erythrocytes ... ICAM-4 and CD36 are implicated in the abnormal adhesiveness to endothelium of sickle cell SAD mouse erythrocytes ... ICAM-4 and CD36 are implicated in the abnormal adhesiveness to endothelium of sickle cell SAD mouse erythrocytes ... Results CD36, CD47 and ICAM-4, but not Lu/BCAM, are present on mouse mature erythrocytes.α4β1 are not expressed on SAD and wild ...
Sensitivity to detect abnormal erythrocyte deformability Article type: Research Article. Authors: Ruef, P. , Pöschl, J.M.B. , ... Keywords: Density-separated erythrocytes, erythrocyte deformability, glutaraldehyde, shear stress diffractometer. DOI: 10.3233/ ... The results show that the Rheodyn SSD is a sensitive tool to detect abnormal RBC deformability. ... The shear stress diffractometer Rheodyn SSD for determination of erythrocyte deformability II. ...
The fetal-maternal erythrocyte distribution test is used to measure the number of the unborn babys red blood cells in a ... What Abnormal Results Mean. In an abnormal test result, blood from the unborn baby is leaking into the mothers blood ... Kleihauer-Betke stain; Flow cytometry - fetal-maternal erythrocyte distribution; Rh incompatibility - erythrocyte distribution ... The fetal-maternal erythrocyte distribution test is used to measure the number of the unborn babys red blood cells in a ...
Abnormal" by people in this website by year, and whether "Erythrocytes, Abnormal" was a major or minor topic of these ... "Erythrocytes, Abnormal" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Erythrocytes, Abnormal" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Erythrocytes, Abnormal". ...
Comments on Abnormal Erythrocytes and Malaria * James Bowman https://doi.org/10.4269/ajtmh.1964.13.159 ... Infections in ducklings produced by P. relictum produced a transient anemia and an increase in the immature erythrocytes. In ... Geographical association of certain genetic erythrocyte abnormalities with regions endemic for falciparum malaria, and the ... as well as taking full advantage of the osmotic fragility of erythrocytes ordinarily found in such infections. This brings me ...
An erythrocyte sedimentation rate measures how quickly red blood cells settle in a test tube. It can help detect inflammation ... Leukocytosis, an abnormal increase in white blood cells. If your results are not in the normal range, it doesnt necessarily ... What is an erythrocyte sedimentation rate (ESR)?. An erythrocyte sedimentation rate (ESR) is a type of blood test that measures ... Erythrocyte Sedimentation Rate (ESR); p. 267-68.. *Lab Tests Online [Internet]. Washington D.C.: American Association for ...
Erythrocyte Sedimentation Rate (ESR) is a commonly done test for inflammation. ESR is raised in many conditions and is a common ... Erythrocyte sedimentation rate is a non-specific test and is not diagnostic of any particular disease. It has a high ... Erythrocyte sedimentation rate (ESR) is a non-specific test for inflammation. It is easy to perform, widely available and ... Erythrocyte Sedimentation Rate. by Shashikiran Umakanth · Published June 10, 2018. · Updated March 27, 2019. ...
There is an exchangeable calcium pool in both normal and sickle cell erythrocytes, comprising about 10-15% of the total ... Erythrocytes / metabolism. Erythrocytes, Abnormal / metabolism*, physiopathology. Humans. Magnesium / blood. Osmolar ... There is an exchangeable calcium pool in both normal and sickle cell erythrocytes, comprising about 10-15% of the total ...
Erythrocyte Sedimentation Rate Definition The erythrocyte sedimentation rate (ESR), or sedimentation rate (sed rate), is a ... Rouleaux- The stacking up of red blood cells, caused by extra or abnormal proteins in the blood that decrease the normal ... Erythrocyte Sedimentation Rate. Definition. The erythrocyte sedimentation rate (ESR), or sedimentation rate (sed rate), is a ... Erythrocyte sedimentation rate (ESR)- The distance that red blood cells settle in a tube of blood in one hour. It is an ...
Functionally Abnormal Na+-K+ Pump in Erythrocytes of a Morbidly Obese Patient. ... Functionally Abnormal Na+-K+ Pump in Erythrocytes of a Morbidly Obese Patient. ... The Na+-K+ pump in the erythrocytes of a mordibly obese patient shows a unique constellation of functional abnormalities. The ... Binding by specific monoclonal Abs was assessed by two methods: rosetting with ox erythrocytes conjugated with goat anti-mouse ...
Erythrocytes of diabetic patients have abnormal membrane properties. We examined in vivo membrane lipid peroxidation in ... There was a significantly increased membrane lipid peroxidation in diabetic erythrocytes compared with nondiabetic erythrocytes ... Erythrocyte Membrane Lipid Peroxidation and Glycosylated Hemoglobin in Diabetes. Sushil K Jain, Robert McVie, John Duett, John ... Erythrocyte Membrane Lipid Peroxidation and Glycosylated Hemoglobin in Diabetes. Sushil K Jain, Robert McVie, John Duett, John ...
Abnormal membrane fluidity and acetylcholinesterase activity in erythrocytes from insulin-dependent diabetic patients. ... Fingerprint Dive into the research topics of Abnormal membrane fluidity and acetylcholinesterase activity in erythrocytes from ...
The condition is asymptomatic among many women, but some may experience an abnormal vaginal discharge and abnormal vaginal ... Elevated erythrocyte sedimentation rate, *. Elevated C-reactive protein, *. Laboratory documentation of cervical infection with ... If the cell count is still abnormal after 2 years, or if a downward trend is not present at each examination, the child should ... Abnormal results of serologic testing (unusually high, unusually low, and fluctuating titers) have been observed among HIV- ...
abnormal cervical mucopurulent discharge or cervical friability;. *presence of abundant numbers of WBC on saline microscopy of ... elevated erythrocyte sedimentation rate;. *elevated C-reactive protein; and. *laboratory documentation of cervical infection ...
Causes of decreased erythrocyte sedimentation rate. Common Causes. *Abnormal erythrocyte morphologies. *Hyperviscosity state ... Directions to Hospitals Treating Erythrocyte sedimentation rate Risk calculators and risk factors for Erythrocyte sedimentation ... The erythrocyte sedimentation rate (ESR), also called sedimentation rate, sed rate, or Biernacki Reaction, is a non-specific, ... 1999). "Clinical utility of the erythrocyte sedimentation rate". Am Fam Physician. 60 (5): 1443-50. PMID 10524488.. Unknown ...
The abnormal cells are usually white blood cells (leukocytes). The bone marrow also makes fewer healthy cells. The abnormal ... Red blood cells (erythrocytes). Red blood cells carry oxygen. When a child has a low level of healthy red blood cells, this is ... When a child has leukemia, the bone marrow makes abnormal blood cells that do not mature. The abnormal cells are usually white ... Its done to stop the bone marrow from making abnormal cells. The goal is to no longer being able to detect cancer cells. This ...
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Humans / Calmodulin / Goats / Erythrocytes / Animals ... Full text: Available Index: IMSEAR (South-East Asia) Main subject: Humans / Calmodulin / Goats / Erythrocytes / Animals ... The goat erythrocyte calmodulin stimulated (Ca(2+)-Mg2+)-ATPase but not (Mg2+)-ATPase and (Na(+)-K(+)-Mg2+)-ATPase. The (Ca(2+ ... Calmodulin was purified from goat erythrocyte hemolysate using heat treatment and Sephadex G-100 gel filtration chromatography ...
... in polychromatic erythrocytes (PCE) and for the ratio of PCE among total erythrocytes at 24 or 48 h after the treatment of mice ... no statistically significant increase was observed for the incidence of micronucleated polychromatic erythrocytes (MNPCE) ... No mortality and abnormal clinical signs in each animal were observed at any dose levels (data not shown). Due to no sex ... in polychromatic erythrocytes (PCE) and for the ratio of PCE among total erythrocytes at 24 or 48 h after the treatment of mice ...
Abnormal erythrocyte choline transport in patients with chronic renal failure Clin Sci (Lond) (February,1991) ... Membrane incorporation of non-esterified fatty acids and effects on the sodium pump of human erythrocytes J. F. St. J. Dwight ... Erythrocyte Membrane and Renal Function in Relation to Hypertension in Rats of the Milan Hypertensive Strain Clin Sci (Lond) ( ... Increased lysine transport capacity in erythrocytes from patients with chronic renal failure Clin Sci (Lond) (April,1989) ...
Note the abnormal membrane appearance of uninfected CC erythrocytes. Comparisons of erythrocyte shapes at early, mid, and late ... A) Parasitized AA erythrocytes surrounded by uninfected erythrocytes. (B) Parasitized CC erythrocytes surrounded by uninfected ... 2D,G). This change was more pronounced in CC erythrocytes. At the schizont stage, both AA and CC erythrocytes were completely ... Uninfected CC erythrocytes have increased band 3 oligomerization compared to uninfected AA erythrocytes, and a considerable ...
Number of Participants With Abnormal Findings in Urine Analysis [ Time Frame: Baseline up to Week 26 ]. The parameters analyzed ... Abbreviations: Abs=Absolute count; ERCS=Erythrocytes; MCHC=Mean corpuscular hemoglobin concentration; MCH=Mean cell hemoglobin. ... Urine analysis findings were considered abnormal as judged by the investigator.. *Number of Participants With Clinically ... Abnormal ECG findings were considered as clinically significant at the discretion of investigator. ...
Abnormal Red Cell Structure and Function in Neuroacanthocytosis. *Judith C. A. Cluitmans, Carlo Tomelleri, +6 authors Giel J. G ... Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte ... Monoclonal antibodies against human erythrocyte band 3 protein. Localization of proteolytic cleavage sites and ... article{Jennings1986MonoclonalAA, title={Monoclonal antibodies against human erythrocyte band 3 protein. Localization of ...
Alterations in this ratio result in abnormal morphology and reduced life span. Glycophorins are sialoglycoproteins that span ... The erythrocyte is a cell with no nucleus and few organelles, and is considered a carrier of oxygen without a role in ... About 40% of the weight of the erythrocyte is composed of lipid. The red cell membrane is comprised of a cholesterol rich ... Another erythrocyte membrane constituent that has been associated with atherosclerosis is hexacosanoate (C26:0), which is a ...
Sensitivity to detect abnormal erythrocyte deformability Authors: Ruef, P. , Pöschl, J.M.B. , Linderkamp, O. , Schmid-Schönbein ... Keywords: Density-separated erythrocytes, erythrocyte deformability, glutaraldehyde, shear stress diffractometer DOI: 10.3233/ ... Erythrocyte membrane alterations in thalassemia intermedia Authors: Fiorelli, G. , Turrini, F. , Mannu, F. , Porro, F. , ... Solubilized erythrocyte membrane proteins were gel-filtered and high-molecular-weight aggregates were isolated and analyzed for ...
The erythrocyte sedimentation rate is elevated. Specific measures of acute inflammation, such as C-reactive protein, are also ... Patients may find it difficult to straighten their fingers and toes, or their hands and feet may curve outward in an abnormal ... Primary OA is caused by abnormal stresses on healthy joints or by normal stresses on weakened joints. The joints most commonly ... Finally, some researchers believe that primary OA may be caused by bone disease, liver problems, or other abnormal conditions ...
Only abnormal lab values are listed. HGB: hemoglobin; TIBC: total iron binding capacity; CRP: C-reactive protein; ESR: ... erythrocyte sedimentation rate; PT: prothrombin time; INR: international normalized ratio; LDH: lactate dehydrogenase; HIV: ... Abnormal laboratory values and the results for the paracentesis are listed in Tables 1 and 2. ... Jejunal biopsies were negative for malignancy, ulcer, abnormal inflammation, or Giardia-like organisms. ...
Inheritence of abnormal erythrocyte sodium counter transport in children of parents with essential hypertension ... Inheritence of abnormal erythrocyte sodium counter transport in children of parents with e ... Index: IMEMR (Eastern Mediterranean) Main subject: Sodium Channels / Erythrocytes / Hypertension Limits: Female / Humans / Male ... Index: IMEMR (Eastern Mediterranean) Main subject: Sodium Channels / Erythrocytes / Hypertension Limits: Female / Humans / Male ...
The large number of abnormal cells. in the bone marrow interferes with the production of functional white blood cells, red ... white blood cells (leukocytes) that protect the body from infection; red blood cells (erythrocytes) that carry oxygen; and ... In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. ... which can result in easy bruising and abnormal bleeding. Other symptoms of familial acute myeloid leukemia with mutated CEBPA ...
The present invention is based on the surprising discovery that erythrocytes conj ... Abnormal values are obtained in many disorders associated with shortened in vivo erythrocyte survival (Clarck et al., 1983, ... Osmotic fragility of control erythrocytes and thrombo-erythrocytes. The lysis of control erythrocytes and thrombo-erythrocytes ... Such modified erythrocytes are termed herein "carrier erythrocytes". The carrier erythrocytes have use in delivery of such ...
Erythrocytes, Abnormal / metabolism * Erythrocytes, Abnormal / pathology* * Erythropoiesis / genetics* * Erythropoietin / ... which is transcriptionally up-regulated during Epo-stimulated in vitro erythrocyte differentiation. Nix null mice are viable ... with splenic and bone marrow erythroblastosis and reduced apoptosis in vivo during erythrocyte maturation. Hematopoietic ... apoptosis in opposition to the Epo-induced erythroblast survival pathway appears indispensable for regulation of erythrocyte ...
  • Erythrocyte sedimentation rate (ESR) is a non-specific test for inflammation. (mediscuss.org)
  • Erythrocyte sedimentation rate is a non-specific test and is not diagnostic of any particular disease. (mediscuss.org)
  • What is an erythrocyte sedimentation rate (ESR)? (medlineplus.gov)
  • An erythrocyte sedimentation rate (ESR) is a type of blood test that measures how quickly erythrocytes (red blood cells) settle at the bottom of a test tube that contains a blood sample. (medlineplus.gov)
  • The erythrocyte sedimentation rate (ESR), or sedimentation rate (sed rate), is a measure of the settling of red blood cells in a tube of blood during one hour. (encyclopedia.com)
  • Erythrocyte sedimentation rate (ESR) - The distance that red blood cells settle in a tube of blood in one hour. (encyclopedia.com)
  • The Erythrocyte Sedimentation Rate: Old and New Clinical Applications. (encyclopedia.com)
  • The erythrocyte sedimentation rate (ESR), also called sedimentation rate , sed rate , or Biernacki Reaction , is a non-specific, indirect measurement of the acute phase reactant concentration which is altered in conditions of inflammation . (wikidoc.org)
  • Although it is frequently ordered, the erythrocyte sedimentation rate (ESR) is not a useful screening test. (wikidoc.org)
  • The clinical usefulness of erythrocyte sedimentation rate (ESR) is limited to monitoring the response to therapy in certain inflammatory diseases such as temporal arteritis , polymyalgia rheumatica and rheumatoid arthritis . (wikidoc.org)
  • Polymyalgia rheumatica without significantly increased erythrocyte sedimentation rate. (nih.gov)
  • An erythrocyte sedimentation rate (ESR) of at least 40 mm/h is considered an important requisite for the diagnosis of polymyalgia rheumatica (PMR). (nih.gov)
  • An elevated erythrocyte sedimentation rate was the only abnormal laboratory finding. (cdc.gov)
  • The degree of membrane lipid peroxidative damage in erythrocytes was significantly correlated with the level of glycosylated hemoglobin, an index of mean glucose level for the preceding 3-4mo. (diabetesjournals.org)
  • Alterations in this ratio result in abnormal morphology and reduced life span. (bmj.com)
  • The laboratory will focus on methods used in the evaluation of abnormal erythrocyte morphology. (aum.edu)
  • There are still many unanswered features of the problem, the resolution of which will add to our understanding of these genetic abnormalities of the erythrocytes and of malaria. (ajtmh.org)
  • Geographical association of certain genetic erythrocyte abnormalities with regions endemic for falciparum malaria, and the absence of the genetic traits in races never so exposed is irrefutable. (ajtmh.org)
  • A study of erythrocyte abnormalities and associated disease states. (aum.edu)
  • Affected individuals also have a reduction in the amount of platelets (thrombocytopenia), which can result in easy bruising and abnormal bleeding. (medlineplus.gov)
  • The present invention is based on the surprising discovery that erythrocytes conjugated to certain peptides and polypeptides containing an R-G-D (Arg-Gly-Asp) sequence (collectively termed herein "RGD peptides") according to the invention, selectively bind to activated platelets but not to unactivated platelets. (freepatentsonline.com)
  • Biopsies of these sites may show macrophages phagocytosing erythrocytes, leukocytes and platelets [ 3 ]. (hindawi.com)
  • Cells derived from the myeloid lineage include red blood cells (erythrocytes), platelets (thrombocytes), and granulocytes and monocytes. (rarediseases.org)
  • Background and objectives Abnormal adhesiveness of red blood cells to endothelium has been implicated in vasoocclusive crisis of sickle cell disease. (haematologica.org)
  • Design and Methods The repertoire of adhesive molecules on mouse erythrocytes and bEnd.3 microvascular endothelial cells was determined by flow cytometry using monoclonal antibodies or by Western blot. (haematologica.org)
  • The fetal-maternal erythrocyte distribution test is used to measure the number of the unborn baby's red blood cells in a pregnant woman's blood. (ucsfhealth.org)
  • Acid pH induces formation of dense cells in sickle erythrocytes. (uchicago.edu)
  • Many diseases make extra or abnormal proteins that cause the red cells to move close together, stack up, and form a column (rouleaux). (encyclopedia.com)
  • Rouleaux - The stacking up of red blood cells, caused by extra or abnormal proteins in the blood that decrease the normal distance red cells maintain between each other. (encyclopedia.com)
  • T cells were prepared by sheep erythrocyte (E) rosetting after removal of adherent cells. (jci.org)
  • When a child has leukemia, the bone marrow makes abnormal blood cells that don't mature. (rochester.edu)
  • The abnormal cells are usually white blood cells (leukocytes). (rochester.edu)
  • The abnormal cells reproduce very quickly. (rochester.edu)
  • A child has symptoms when he or she has more abnormal cells and less normal cells. (rochester.edu)
  • Red blood cells (erythrocytes). (rochester.edu)
  • In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. (medlineplus.gov)
  • Absence of the tumor suppressor function of CCAAT enhancer-binding protein alpha is believed to disrupt the regulation of blood cell production in the bone marrow, leading to the uncontrolled production of abnormal cells that occurs in acute myeloid leukemia. (medlineplus.gov)
  • Erythrocytes are stored in the spleen, which acts as a reservoir for the blood system and discharges the cells into the blood as required. (thefreedictionary.com)
  • in vitro, when infected blood is incubated with monolayers of human melanoma cells, trophozoite/schizont-infected erythrocytes from intact animals but not from splenectomized animals bind to the melanoma cells. (pnas.org)
  • Immune serum can inhibit and reverse in vitro binding to melanoma cells of infected erythrocytes from intact animals. (pnas.org)
  • The health span of supercentenarians might be partly explained by the expansion of T cells that kill infected or abnormal cells. (pnas.org)
  • Sickled red blood cells have an abnormal shape and do not tend to form stacks of cells (rouleaux formation). (bartleby.com)
  • The characteristic that highlights GLUT1 is its association with erythrocytes and epithelial cells in the blood-brain barrier. (bartleby.com)
  • This remaining blood pool of HIV very likely reflects the continuous replication in infected cells, with subsequent release and attachment to erythrocytes. (jimmunol.org)
  • Because HIV on erythrocytes remains infectious, this pool of viruses might contribute to continuous reinfection of other cells. (jimmunol.org)
  • Whereas many cells have specific receptors for HIV, none is known on erythrocytes. (jimmunol.org)
  • The scalloped or notched appearance of the periphery of erythrocytes found when the cells are suspended in a hypertonic solution. (free-ed.net)
  • Defective DNA synthesis resulting in unusually large stem cells in the marrow that mature into unusually large erythrocytes in the circulation. (powershow.com)
  • The cytoplasm of erythrocytes is rich in hemoglobin , an iron -containing biomolecule that can bind oxygen and is responsible for the red color of the cells and the blood. (wikipedia.org)
  • A membrane skeleton lies on the inner surface of the lipid bilayer of the erythrocyte membrane and is important in maintaining the structural integrity of red blood cells. (els.net)
  • In a woman whose blood is Rh incompatible with her infant, this test helps find out how much Rh immune globulin (RhoGAM) she must receive to prevent her body from producing abnormal proteins that attack the unborn baby in future pregnancies. (ucsfhealth.org)
  • and the abnormal deposition of heme and heme proteins on membranes of sickle erythrocytes. (nih.gov)
  • Recent genomic research has shown that defects in proteins that constitute the erythrocyte membrane skeleton are often the causes of these disorders. (els.net)
  • The peripheral membrane proteins ankyrin, protein 4.2, actin and protein 4.1 anchor the spectrin scaffold to the lipid bilayer by attaching to the major erythrocyte integral membrane proteins, band 3 and the glycophorins. (els.net)
  • Changes in erythrocyte volume in relation to characteristics of protein phosphorylation of the membrane cytoskeleton in hypertension: role of protein kinase C]. Kardiologiia. (uchicago.edu)
  • Monoclonal antibodies against human erythrocyte band 3 protein. (semanticscholar.org)
  • The atheroma rich lesions were mainly observed in chronic thromboembolic pulmonary hypertension and stained strongly positive for the erythrocyte specific membrane protein glycophorin. (bmj.com)
  • In the thrombo-erythrocytes of the invention, preferably, the N-terminal Arg of the R-G-D sequence should be spaced within 9-50 Angstroms, more preferably 10-40 Angstroms, and most preferably 11-25 Angstroms, from the erythrocyte protein to which the RGD peptide is conjugated. (freepatentsonline.com)
  • Deletion of the retinoblastoma protein rescued the increased size displayed by erythrocytes lacking Cdk2 and Cdk4, indicating that the retinoblastoma/Cdk2/Cdk4 pathway regulates erythrocyte size. (haematologica.org)
  • PD and MSA are alpha-synucleinopathies, which are characterized by the abnormal accumulation of alpha-synuclein, while tau protein accumulates in PSP. (clinicaltrials.gov)
  • The oligomeric alpha-synuclein seems to be particularly involved in abnormal protein aggregation in alpha-synucleinopathies. (clinicaltrials.gov)
  • CSF is frequently abnormal in the presence of ADEM, with moderately increased leukocyte and protein levels. (ajnr.org)
  • The layer of leukocytes that collects immediately above the erythrocytes in sedimented or centrifuged whole blood. (free-ed.net)
  • Leukemia is defined as the uncontrolled proliferation of abnormal leukocytes in the blood and bone marrow. (rarediseases.org)
  • 2000). Thus, Plasmodium-infected erythrocytes are under increased oxidative stress exerted by the malaria parasite. (who.int)
  • Defects in SPTA1 gene leads to unstable RBCs membrane, characterized by peripheral accumulated RBCs with abnormal shape, such as hereditary spherocytosis (HS), hereditary elliptocytosis (HE) and hereditary pyropoikilocytosis (HPP). (lww.com)
  • Experiments in humans have shown that different Ag/Ab IC bind to erythrocytes and are transported to liver and spleen ( 17 , 18 ). (jimmunol.org)
  • Erythrocyte membrane disorders, such as hereditary spherocytosis and elliptocytosis, usually present with abnormal red cell shapes, hemolysis and anemia. (els.net)
  • The molecular stability of hemoglobin is critical for normal erythrocyte functions, including oxygen transport. (biologists.org)
  • The functions of erythrocytes include transportation of oxygen and carbon dioxide. (thefreedictionary.com)
  • If there is too much Oxygen then (EPO) falls and erythrocyte production slows. (prezi.com)
  • The growth of Plasmodium falciparum is abnormal in homozygous CC erythrocytes in vitro, and CC individuals show innate protection against severe P. falciparum malaria. (biologists.org)
  • We found that the accessibility of an intracellular band 3 epitope to antibody was markedly reduced in CC compared to AA erythrocytes, indicating a high degree of band 3 clustering in CC erythrocytes in vivo and during intracellular parasite development in vitro. (biologists.org)
  • We used gene targeting in the mouse to evaluate the BH3-only factor Nix, which is transcriptionally up-regulated during Epo-stimulated in vitro erythrocyte differentiation. (nih.gov)
  • We developed an in vitro model to study the factors involved in the adherence of HIV-1 to erythrocytes. (jimmunol.org)
  • The 1995 Meeting recommended re-evaluation of ethephon in 1997 to take into account the results of a study that was under way of the effects of the compound on rat plasma and erythrocyte cholinesterase activity in vitro. (inchem.org)
  • Potassium Cyanate as an Inhibitor of the Sickling of Erythrocytes In Vitro. (springer.com)
  • Increased Survival of Sickle-Cell Erythrocytes after Treatment In Vitro with Sodium Cyanate. (springer.com)
  • Similarly, antibody can reverse in vivo sequestration as shown by the appearance of trophozoite/schizont-infected erythrocytes in the peripheral blood of an intact animal after inoculation with immune serum. (pnas.org)
  • We observed that, when opsonized in normal human serum, not only HIV-IC, but also HIV, bound to erythrocytes, although the adherence of HIV was lower than that of HIV-IC. (jimmunol.org)
  • The results of erythrocyte and serum cholinesterase activity assays were concordant in 83% of patients. (aappublications.org)
  • We examined in vivo membrane lipid peroxidation in erythrocytes of diabetic subjects and its possible relationship with hyperglycemia. (diabetesjournals.org)
  • Nix null mice exhibited massive splenomegaly, with splenic and bone marrow erythroblastosis and reduced apoptosis in vivo during erythrocyte maturation. (nih.gov)
  • The mechanism by which HIV is attached to erythrocytes in vivo is unknown. (jimmunol.org)
  • Abnormal laboratory values and the results for the paracentesis are listed in Tables 1 and 2 . (hindawi.com)
  • Local laboratory standards determine which results are normal and which are abnormal. (medscape.com)
  • Erythrocyte: Structure & Metabolism หัวข้อบรรยาย 1. (bartleby.com)
  • Clinical Hemorheology and Microcirculation , a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. (iospress.com)
  • Brugnara C (1997) Erythrocyte membrane transport physiology. (els.net)
  • Erythrocyte formation ( erythropoiesis ) takes place in the red bone marrow in the adult, and in the liver, spleen, and bone marrow of the fetus. (thefreedictionary.com)
  • Results CD36, CD47 and ICAM-4, but not Lu/BCAM, are present on mouse mature erythrocytes.α 4 β 1 are not expressed on SAD and wild type reticulocytes. (haematologica.org)
  • The results show that the Rheodyn SSD is a sensitive tool to detect abnormal RBC deformability. (iospress.com)
  • If your ESR results are abnormal, your health care provider will need more information and will likely order more lab tests before making a diagnosis. (medlineplus.gov)
  • In sickle cell disease, the instability of HbS results in premature senescence of erythrocytes, as suggested by increased amounts of membrane-bound autologous IgG ( Bosman, 2004 ). (biologists.org)
  • Here, we present the results of single-cell studies of total fluorescence intensity and distribution of band 3 in uninfected and infected erythrocytes using power spectra and 1D autocorrelation analyses. (biologists.org)
  • If the results are abnormal, your child's healthcare provider may recommend that your child see a pediatric cancer specialist (pediatric oncologist). (ahealthyme.com)
  • These results indicate that the spleen modulates the expression of parasite alterations of the infected erythrocyte membrane responsible for sequestration and suggest that the prevention and reversal of sequestration could be one of the effector mechanisms involved in antibody-mediated protection against P. falciparum malaria. (pnas.org)
  • reference ranges for test results (normal, abnormal, etc. (findacode.com)
  • Sickle-cell disease is a genetic disease that results in abnormal hemoglobin molecules. (wikidoc.org)
  • Thalassemia is a genetic disease that results in the production of an abnormal ratio of hemoglobin subunits. (wikidoc.org)
  • Concern about mild bleeding history and abnormal coagulation tests prompted dialysis without heparin. (annals.org)
  • Sequestration, the adherence of infected erythrocytes containing late developmental stages of the parasite (trophozoites and schizonts) to the endothelium of capillaries and venules, is characteristic of Plasmodium falciparum infections. (pnas.org)
  • This suggests that peroxidation of membrane lipids and accumulation of MDA occurs in erythrocytes of diabetic patients. (diabetesjournals.org)
  • PD and MSA belong to the alpha-synucleinopathies, which are characterized by the abnormal accumulation of alpha-synuclein. (clinicaltrials.gov)
  • Echinocyte (from the Greek word echinos, meaning 'hedgehog' or 'sea urchin'), in human biology and medicine, refers to a form of red blood cell that has an abnormal cell membrane characterized by many small, evenly spaced thorny projections. (wikipedia.org)
  • Calcium exchange and calcium-related effects in normal and sickle cell anemia erythrocytes. (biomedsearch.com)
  • There is an exchangeable calcium pool in both normal and sickle cell erythrocytes, comprising about 10-15% of the total cellular calcium. (biomedsearch.com)
  • We investigated one possible mechanism of innate protection using a quantum dot technique to compare the distribution of host membrane band 3 molecules in genotypically normal (AA) to CC erythrocytes. (biologists.org)
  • Erythrocytes have diminished biconcavity, a smaller than normal diameter, increased density, an appearance of exovesiculation, and a short lifespan. (jax.org)
  • Erythrocytes also are important in the maintenance of a normal acid-base balance , and, since they help determine the viscosity of the blood, they also influence its specific gravity. (thefreedictionary.com)
  • SCT is the heterozygous form of sickle cell anemia, a severe disease resulting from a single genetic mutation occurring on the β-globin gene and responsible for the synthesis of abnormal hemoglobin (Hb), known as HbS. (diabetesjournals.org)
  • O28.5 Abnormal chromosomal and genetic finding on a. (icd10data.com)
  • However, data on the prevalence and impact of abnormal ROTEM(®) assays are scarce. (nih.gov)
  • Nucleated red blood cell (RBC) precursors stimulated by erythropoietin form erythrocytes in the bone marrow. (thefreedictionary.com)
  • Body weights and food consumption were measured at least weekly, and animals were observed daily for any abnormal clinical signs. (inchem.org)
  • Stewart GW and Turner EJ (1999) The hereditary stomatocytoses and allied disorders: congenital disorders of erythrocyte membrane permeability to Na and K. Baillière's Best Practice and Research: Clinical Haematology 12: 707-727. (els.net)
  • In addition, no statistically significant increase was observed for the incidence of micronucleated polychromatic erythrocytes (MNPCE) in polychromatic erythrocytes (PCE) and for the ratio of PCE among total erythrocytes at 24 or 48 h after the treatment of mice with ATEC or DEHP. (nature.com)
  • The ratio of cholesterol and phospholipid content is related to the fluid properties of the erythrocyte membrane. (bmj.com)
  • Animals were cytopenic, having reduced numbers of erythrocytes, monocytes and granulocytes. (springer.com)
  • 1. Sodium pump function has been assessed by measurement of ouabain-sensitive 86 Rb uptake in human erythrocytes after incorporation of palmitic, stearic, oleic and linoleic acids into the erythrocyte membrane. (portlandpress.com)
  • Radiolabeled HIV-1 (HIV) and preformed HIV-1/anti-HIV immune complexes (HIV-IC) were opsonized in various human sera, purified using sucrose density gradient ultracentrifugation, and incubated with human erythrocytes. (jimmunol.org)
  • The spleen may discharge extra erythrocytes into the blood during emergencies such as hemorrhage or shock. (thefreedictionary.com)
  • An abnormal decrease in the number of basophils. (free-ed.net)
  • This syndrome may result from cytotoxic immune dysregulation leading to abnormal T-lymphocyte and macrophage activation and subsequent inflammatory cytokine production [ 2 ]. (hindawi.com)
  • Most chronic infections and inflammatory syndromes have abnormal sed rates that run in the 80 to 100 range. (dummies.com)
  • The goat erythrocyte calmodulin stimulated (Ca(2+)-Mg2+)- ATPase but not (Mg2+)- ATPase and (Na(+)-K(+)-Mg2+)- ATPase . (bvsalud.org)
  • The (Ca(2+)-Mg2+)- ATPase of the erythrocyte membrane derived from human , rat , rabbit and pig were significantly stimulated. (bvsalud.org)
  • In spite of this constant destruction and production of erythrocytes, the body maintains a fairly constant number, between 4 and 5 million per mm 3 of blood in women and 5 to 6 million per mm 3 in men. (thefreedictionary.com)
  • The switch in cytoadherence characteristics of the infected erythrocytes from nonbinding to binding occurs with a cloned parasite. (pnas.org)
  • Erythrocytes, Abnormal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Thus, erythrocytes may not only deliver HIV-IC to organs susceptible to infection, but free HIV as well. (jimmunol.org)
  • Physical examination showed no distress, fever, or abnormal findings other than muscle tenderness. (annals.org)
  • O28.8 Other abnormal findings on antenatal screenin. (icd10data.com)
  • O28.9 Unspecified abnormal findings on antenatal sc. (icd10data.com)
  • R76 Other abnormal immunological findings in. (icd10data.com)
  • R79 Other abnormal findings of blood chemist. (icd10data.com)
  • R83.4 Abnormal immunological findings in cerebrospi. (icd10data.com)
  • R83.5 Abnormal microbiological findings in cerebros. (icd10data.com)
  • R83.6 Abnormal cytological findings in cerebrospina. (icd10data.com)
  • R83.8 Other abnormal findings in cerebrospinal flui. (icd10data.com)
  • R84 Abnormal findings in specimens from respirato. (icd10data.com)