AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Erythrocyte TransfusionCinnarizineFlunarizineBlood TransfusionErythrocytesBlood Loss, SurgicalAnemiaErythrocyte MembranePlatelet TransfusionExchange Transfusion, Whole BloodBlood Transfusion, AutologousBlood Component TransfusionErythrocyte AgingBlood Transfusion, IntrauterineFetofetal TransfusionErythrocyte DeformabilityAnion Exchange Protein 1, ErythrocyteHemolysisErythrocyte CountBlood Grouping and CrossmatchingHemoglobins
Erythrocyte Transfusion
The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
Cinnarizine
A piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.
Flunarizine
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Blood Transfusion
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
Erythrocytes
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Blood Loss, Surgical
Loss of blood during a surgical procedure.
Anemia
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
Erythrocyte Membrane
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
Platelet Transfusion
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
Exchange Transfusion, Whole Blood
Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
Blood Transfusion, Autologous
Reinfusion of blood or blood products derived from the patient's own circulation. (Dorland, 27th ed)
Blood Component Transfusion
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
Erythrocyte Aging
The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.
Blood Transfusion, Intrauterine
In utero transfusion of BLOOD into the FETUS for the treatment of FETAL DISEASES, such as fetal erythroblastosis (ERYTHROBLASTOSIS, FETAL).
Fetofetal Transfusion
Passage of blood from one fetus to another via an arteriovenous communication or other shunt, in a monozygotic twin pregnancy. It results in anemia in one twin and polycythemia in the other. (Lee et al., Wintrobe's Clinical Hematology, 9th ed, p737-8)
Erythrocyte Deformability
Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.
Anion Exchange Protein 1, Erythrocyte
A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
Erythrocyte Count
The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.
Blood Grouping and Crossmatching
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
Hemoglobins
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.

Intrauterine management of fetal parvovirus B19 infection. (1/717)

OBJECTIVES: The aim of our study was to determine the outcome of pregnancies after intrauterine management of fetal parvovirus B19 infection. DESIGN: Retrospective study. SUBJECTS: A total of 37 cases of maternofetal parvovirus B19 infection, 35 of which were associated with hydrops fetalis, were referred to our tertiary level center between 1989 and 1996. With regard to fetal hydrops, no apparent cause other than parvovirus B19 infection was found in any patient. METHODS: In all patients, cordocentesis was performed to assess the degree of fetal anemia. When anemia was present, cordocentesis was followed by intrauterine transfusion with packed red cells into the umbilical vein. Further management depended on the degree of fetal anemia and gestational age and included follow-up fetal blood sampling/transfusion as well as ultrasound examinations as deemed appropriate. RESULTS: Packed red cell transfusion was performed in 30 patients with significant fetal anemia (Z-score 1.6-7.8 below the mean for gestational age). The fetal hemoglobin values ranged from 2.1 to 9.6 g/dl. Serum levels of platelets in the transfusion group were 9-228 x 10(9)/l with Z-scores in the range of < 1 to 3.8 below the mean. During treatment and follow-up, there were five intrauterine deaths (13.5%), one neonatal death (2.7%) and 31 live births (83.8%). CONCLUSIONS: Fetal parvovirus infection can lead to marked anemia and hydrops formation. Cordocentesis allows precise assessment of fetal anemia which can then be corrected by intravenous transfusion. Under this regimen, the outcome proved favorable in the majority of fetuses, even those that were severely anemic.  (+info)

Allogeneic stem cell transplantation for agnogenic myeloid metaplasia: a European Group for Blood and Marrow Transplantation, Societe Francaise de Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study. (2/717)

Agnogenic myeloid metaplasia (AMM) is a chronic myeloproliferative disorder in which patients with poor prognostic features, receiving conventional treatments, have a median survival of less than 3 years. In this retrospective multicenter study, we analyze the results and try to define the indications for allogeneic stem cell transplantation in AMM. From January 1979 to November 1997, 55 patients with a median age of 42 years were transplanted from HLA-matched related (n = 49) or alternative (n = 6) donors for AMM. A multivariate analysis was conducted to identify factors associated with posttransplant outcome. The median posttransplant follow-up was 36 months (range, 6 to 223). The 5-year probability of survival was 47% +/- 8% for the overall group, and 54% +/- 8% for patients receiving an unmanipulated HLA-matched related transplant. The 1-year probability of transplant-related mortality was 27% +/- 6%. Hemoglobin level +info)

Survival of donor leukocyte subpopulations in immunocompetent transfusion recipients: frequent long-term microchimerism in severe trauma patients. (3/717)

We recently reported detection of a transient increase in circulating donor leukocytes (WBCs) in immunocompetent recipients 3 to 5 days posttransfusion (tx) (Blood 85:1207, 1995). We have now characterized survival kinetics of specific donor WBC subsets in additional tx populations. Eight female elective surgery patients (pts) were sampled pre-tx and on days 1, 3, 5, 7, and 14 post-tx. Ten female trauma pts transfused with a total of 4 to 18 U of relatively fresh red blood cells were sampled up to 1.5 years post-tx. WBC subsets from frozen whole blood were isolated using CD4, CD8 (T cell), CD15 (myeloid), and CD19 (B cell) antibody-coated magnetic beads. Donor WBCs were counted by quantitative polymerase chain reaction (PCR) of male-specific sex determining region (SRY) sequences. PCR HLA typing and mixed leukocyte reaction (MLR) between recipient and donor WBCs were performed on two of the trauma tx recipients who had long-term chimerism of donor cells post-tx. In 6 of 8 female surgery pts, circulating CD4(+) male donor cells peaked at day 3 or 5 (0.01 to 1 cell/microL), followed by clearance by day 14. In 7 of 10 female trauma pts, we observed multilineage persistence of male donor WBCs (CD4, CD8, CD15, CD19) for 6 months to 1.5 years post-tx at concentrations of 10 to 100 cells/microL. In 2 trauma recipients studied, MLR showed no, or very low, response to WBC of the single donor implicated as the source of microchimerism by HLA typing. Establishment of long-term multilineage chimerism in trauma recipients is probably caused by engraftment of donor stem cells and mutual tolerance between recipient and donor leukocytes. A better understanding of factors determining clearance versus chimerism of transfused leukocytes is critical to prevention of alloimmunization and transfusion-induced graft-versus-host disease, and, potentially, to induction of tolerance for transplantation.  (+info)

Acute normovolaemic haemodilution vs controlled hypotension for reducing the use of allogeneic blood in patients undergoing radical prostatectomy. (4/717)

Blood loss in patients undergoing radical prostatectomy may be substantial. In a randomized, prospective study, we assessed two methods of reducing the need for allogeneic blood transfusion with regard to efficacy and costs. Sixty patients undergoing retropubic radical prostatectomy were allocated randomly to one of three groups. In group 1 (n = 20), acute normovolaemic haemodilution (ANH) was initiated after induction of anaesthesia; autologous blood 15 ml kg-1 was withdrawn and replaced by colloid solutions (gelatin) to maintain haemodynamic stability. In group 2 (n = 20), controlled hypotension was established using sodium nitroprusside (target mean arterial pressure (MAP) approximately 50 mm Hg). Group 3 (n = 20), without manipulations, served as a control group. Troponin T (TnT), a sensitive marker for myocardial ischaemia, and various coagulation variables were measured in the perioperative period. Packed red blood cells (PRBC) were given when haemoglobin concentration was less than 7 g dl-1. Cost calculations did not include hospital overhead costs or staff costs. In the ANH group, mean 1278 (SD 150) ml of autologous blood were withdrawn. Significantly more volume was infused in the ANH patients (gelatin 2450 (550) ml) than in the two other groups. Coagulation data (platelet count, activated partial thromboplastin time (aPTT), fibrinogen, antithrombin III (AT III), D-dimers) did not differ significantly between the three groups. The hypotension group had significantly lower blood loss (1260 (570) ml), whereas the ANH (1820 (680) ml) and control group (1920 (590) ml) did not differ significantly. Patients in the hypotension group needed significantly less PRBC (total 14 units; 75% of patients did not need PRBC) than the ANH (total 21 units; 55% of patients did not need PRBC) or control patients (total 28 units; 40% of patients did not need PRBC). Total costs were lowest in the hypotension group (41% less than in the control patients) (P < 0.05). We conclude that the use of hypotension during radical prostatectomy resulted in approximately 40% reduction in total transfusion costs. ANH was less effective and more costly than controlled hypotension.  (+info)

Kinetics of peroxidases in guinea pig bone marrow under immunostimulation. (5/717)

Eosinophil peroxidase and myeloperoxidase play an important role in the host defense. Both enzymes are present in bone marrow, synthesized by blood progenitor cells. This research investigated the kinetic properties of peroxidases under immunostimulation in guinea pig bone marrow. Results suggest that there are at least two myeloperoxidase isozymes and at least three eosinophil peroxidase isozymes in guinea pig bone marrow and that some of these isozymes are expressed upon immunostimulation.  (+info)

Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports. (6/717)

OBJECTIVE: To receive and collate reports of death or major complications of transfusion of blood or components. DESIGN: Haematologists were invited confidentially to report deaths and major complications after blood transfusion during October 1996 to September 1998. SETTING: Hospitals in United Kingdom and Ireland. SUBJECTS: Patients who died or experienced serious complications, as defined below, associated with transfusion of red cells, platelets, fresh frozen plasma, or cryoprecipitate. MAIN OUTCOME MEASURES: Death, "wrong" blood transfused to patient, acute and delayed transfusion reactions, transfusion related acute lung injury, transfusion associated graft versus host disease, post-transfusion purpura, and infection transmitted by transfusion. Circumstances relating to these cases and relative frequency of complications. RESULTS: Over 24 months, 366 cases were reported, of which 191 (52%) were "wrong blood to patient" episodes. Analysis of these revealed multiple errors of identification, often beginning when blood was collected from the blood bank. There were 22 deaths from all causes, including three from ABO incompatibility. There were 12 infections: four bacterial (one fatal), seven viral, and one fatal case of malaria. During the second 12 months, 164/424 hospitals (39%) submitted a "nil to report" return. CONCLUSIONS: Transfusion is now extremely safe, but vigilance is needed to ensure correct identification of blood and patient. Staff education should include awareness of ABO incompatibility and bacterial contamination as causes of life threatening reactions to blood.  (+info)

Epoetin alpha prevents anaemia and reduces transfusion requirements in patients undergoing primarily platinum-based chemotherapy for small cell lung cancer. (7/717)

Anaemia commonly occurs in cancer patients receiving chemotherapy, often necessitating blood transfusion. This multicentre study was designed to evaluate the efficacy and safety of epoetin alpha in preventing the decline in haemoglobin (Hb) level, and to determine whether the transfusion requirement could be reduced, in patients receiving 4-6 cycles of primarily platinum-based combination cyclic chemotherapy for small cell lung cancer (SCLC). A total of 130 non-anaemic SCLC patients were randomized to receive no additional treatment (n = 44), epoetin alpha 150 IU kg(-1) subcutaneously (s.c.) three times a week (n = 42) or 300 IU kg(-1) s.c. three times a week (n = 44). Reductions in epoetin alpha dosage were made during the study if Hb level increased to >15 g dl(-1). The mean weekly dosage was 335 and 612 IU kg(-1), respectively, in the two active treatment groups. Significantly fewer (P < 0.05) epoetin alpha-treated patients experienced anaemia (Hb < 10 g dl(-1)) during the course of chemotherapy (300 IU kg(-1), 39%; 150 IU kg(-1), 48%; untreated, 66%). This was reflected in the significantly lower number of treated patients transfused [300 IU kg(-1), 20% (P< 0.001); 150 IU kg(-1), 45% (P< 0.05); untreated, 59%]. Epoetin alpha was well-tolerated, and there was no evidence of sustained, clinically significant, hypertension. In summary, epoetin alpha is effective and well-tolerated in maintaining Hb level and reducing transfusion requirement in patients undergoing cyclic chemotherapy for SCLC.  (+info)

Early IL-12 p70, but not p40, production by splenic macrophages correlates with host resistance to blood-stage Plasmodium chabaudi AS malaria. (8/717)

In this study, we compared synthesis of IL-12, a potent Th1-inducing cytokine, by splenic macrophages recovered from resistant C57Bl/6 (B6) mice, which develop predominantly Th1 responses, and susceptible A/J mice that mount primarily Th2 responses during early Plasmodium chabaudi AS infection. Quantitative analysis of IL-12 p40 and p70 release by ELISA revealed significant differences between resistant B6 and susceptible A/J mice in the synthesis of biologically active IL-12 p70, but not p40, by splenic macrophages during early blood-stage P. chabaudi AS infection. Despite up-regulation in p40 and p35 mRNA levels, spontaneous release of p40 in vitro by splenic macrophages was not significantly increased following infection in either mouse strain. In contrast, spontaneous release of p70 by splenic macrophages was increased in cells from B6 mice and levels were significantly higher compared with A/J mice. Furthermore, compared with infected A/J hosts, splenic macrophages recovered from infected B6 mice produced significantly greater quantities of IL-12 p70, but not p40, in vitro, following stimulation with lipopolysaccharide (LPS) or malaria parasite antigen (PRBC). Moreover, we found significant increases in the percentage of macrophages earlier in the spleens of infected B6 mice that could further contribute to differences in total p70 levels in vivo. Taken together, these data suggest that macrophage IL-12 synthesis may contribute to the polarization of Th responses seen in resistant B6 and susceptible A/J mice during acute blood-stage malaria.  (+info)

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with...
Many people diagnosed with haematological malignancies experience anaemia, and red blood cell (RBC) transfusion plays an essential supportive role in their management. Different strategies have been developed for RBC transfusions. A restrictive transfusion strategy seeks to maintain a lower haemoglobin level (usually between 70 g/L to 90 g/L) with a trigger for transfusion when the haemoglobin drops below 70 g/L), whereas a liberal transfusion strategy aims to maintain a higher haemoglobin (usually between 100 g/L to 120 g/L, with a threshold for transfusion when haemoglobin drops below 100 g/L). In people undergoing surgery or who have been admitted to intensive care a restrictive transfusion strategy has been shown to be safe and in some cases safer than a liberal transfusion strategy. However, it is not known whether it is safe in people with haematological malignancies.To determine the efficacy and safety of restrictive versus liberal RBC transfusion strategies for people diagnosed with
https://www.ndorms.ox.ac.uk/publications/673280
Liberal vs. Restrictive Transfusion Strategies: Are We Still Following the Results of the TRICC Trial? | Topics in Evidence...Liberal vs. Restrictive Transfusion Strategies: Are We Still Following the Results of the TRICC Trial? | Topics in Evidence...
A new randomized multicenter pilot study involving six ICUs in the United Kingdom was recently published in Critical Care Medicine journal.9 The authors in this study compared hemoglobin concentration (Hb), RBC use, and patient outcomes when restrictive or liberal blood transfusion strategies are used to treat anemic (Hb ≤ 90 g/L) critically ill patients of age ≥ 55 years requiring ≥ 4 days of mechanical ventilation in the ICU. One hundred patients were randomized to restrictive transfusion strategy targeting 71-90 g/L (n=51) and to liberal transfusion strategy targeting 91-110 g/L (n=49) for 14 days or the remainder of ICU stay, whichever was longest. ...
http://accesspharmacy.mhmedical.com/content.aspx?bookid=533§ionid=44337409
A restrictive policy for red blood cell transfusion in older hip fracture patients: experiences from a patient registerA restrictive policy for red blood cell transfusion in older hip fracture patients: experiences from a patient register
Background: Allogeneic red blood cell transfusions (ABT) are common in older hip fracture patients. Recent research supports a restrictive transfusion policy. The aim was to study variation in hemoglobin (Hb) concentration, and clinical outcomes in these patients.. Results: Cross-sectional study with one-year follow-up in an orthogeriatric unit. Data were obtained from a quality register with demographic and medical information collected by an interdisciplinary team. 106 (22 %) of the 491 patients admitted from September 2011 throughout September 2012 (76 % women, mean age 85 years) received ABT. When given ABT, 80 % had Hb ,80 g/l and mean Hb was 78 g/l. Mean Hb, regardless ABT, showed variation from 125 g/l (±16) on admission to 106 g/l (±17), 101 g/l (±16) and 102 g/l (±14) on 1st, 3rd and 5th postoperative day respectively. Patients with per-/subtrochanteric fractures more often received ABT than those with femur neck fractures (p , 0.001), 70 % of the patients receiving ABT had a ...
http://bora.uib.no/handle/1956/15759
Systematic review of the use of fibrin sealant to minimize perioperative allogeneic blood transfusion<...
TY - JOUR. T1 - Systematic review of the use of fibrin sealant to minimize perioperative allogeneic blood transfusion. AU - Carless, Paul A.. AU - Anthony, Danielle M.. AU - Henry, D. A.. PY - 2002. Y1 - 2002. N2 - Background: Fibrin sealants have become popular in improving perioperative haemostasis and reducing the need for allogeneic red cell transfusion. Methods: A systematic review of randomized controlled trials was conducted to examine the efficacy of fibrin sealants in reducing perioperative blood loss and allogeneic red blood cell transfusion. Studies were identified by computer searches of Medline, Embase, Current Contents, the Cochrane Library, manufacturer websites (to January 2001), and bibliographic searches of published articles. Trials were eligible for inclusion if they involved adult elective surgery and reported quantitative data on blood loss, the proportion of patients exposed to allogeneic red cell transfusion and/or the volume of blood transfused. Results: Twelve trials ...
https://research.bond.edu.au/en/publications/systematic-review-of-the-use-of-fibrin-sealant-to-minimize-periop
Transfusion Medicine - Choosing Wisely CanadaTransfusion Medicine - Choosing Wisely Canada
Indications for red blood transfusion depend on clinical assessment and the cause of the anemia. In a stable, non-bleeding patient, often a single unit of blood is adequate to relieve patient symptoms or to raise the hemoglobin to an acceptable level. Transfusions are associated with increased morbidity and mortality in high-risk hospitalized inpatients. Transfusion decisions should be influenced by symptoms and hemoglobin concentration. Single unit red cell transfusions should be the standard for non-bleeding, hospitalized patients. Additional units should only be prescribed after re-assessment of the patient and their hemoglobin value.. Sources:. Bracey AW, et al. Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome. Transfusion. 1999 Oct;39(10):1070-7. PMID: 10532600.. Carson JL, et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev. 2012 Apr 18;(4):CD002042. ...
https://choosingwiselycanada.org/transfusion-medicine/
Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. - NataonlineRandomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. - Nataonline
transfusion of red blood cells in preterm infants. The data confirm a significant reduction of the number of transfused red blood cell units with a restrictive transfusion strategy. However, the infants in the restrictive transfusion group were more likely ...
https://nataonline.com/2005/06/15/randomized-trial-of-liberal-versus-restrictive-guidelines-for-red-blood-cell-transfusion-in-preterm-infants/
Aneurysmal SubArachnoid Hemorrhage-Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial...Aneurysmal SubArachnoid Hemorrhage-Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial...
Transfusion threshold adherence will be described as the proportion of per protocol RBC transfusion events. A transfusion threshold event is defined as an occurrence which starts when a haemoglobin value is measured at or below the allocated threshold for the first time since the previous event and ends when one of the following occurs: (1) an RBC transfusion is administered; or (2) a repeat haemoglobin is obtained above the allocated threshold within 24 hours of the original measure.. Transfusion threshold non-adherence will be considered to have occurred with any of the following: (1) an RBC transfusion occurs before a transfusion threshold is crossed; or (2) in the liberal arm, a transfusion is not given following a threshold crossing. Transfusion threshold non-adherence will be considered a deviation if: (1) the early transfusion occurs within 5 g/L above the allocated threshold (eg, ≤105 g/L for the liberal arm or ≤85 g/L for the restrictive arm) or, (2) in the liberal arm, an RBC ...
http://bmjopen.bmj.com/content/6/12/e012623
Restrictive Versus Liberal Red Cell Transfusion Strategy in Orthopedic-Oncology Patients Undergoing Surgery - a Randomized...Restrictive Versus Liberal Red Cell Transfusion Strategy in Orthopedic-Oncology Patients Undergoing Surgery - a Randomized...
The rationale for perioperative red blood cell (RBC) transfusion is based on the observation that anemia is an independent risk factor for morbidity and mortality after cardiac operations. However, transfusions have been associated with high rates of morbidity and mortality in critically ill patients, and some recent studies have shown worse outcomes, including increased occurrence of renal failure and infection, as well as respiratory, cardiac, and neurological complications, in transfused compared with non transfused patients after cardiac surgery. On the basis of past clinical observations, some authors have suggested that hematocrit should be maintained at around 30% and hemoglobin concentration at 10 g/dL. Recently, however, this hemoglobin threshold has been reconsidered because of recognized risks associated with transfusion and greater appreciation of the importance of individual physiological responses to anemia. In a comparative trial of 428 patients undergoing elective coronary artery ...
https://clinicaltrials.gov/ct2/show/NCT01491308?recr=Open&cond=%22Blood+Cells%22&rank=15
Adverse effects of small-volume red blood cell transfusions in the neonatal population. - Nuffield Department of Orthopaedics,...
BACKGROUND: Adverse transfusion reactions in the neonatal population are poorly understood and defined. The incidence and pattern of adverse effects due to red blood cell (RBC) transfusion are not well known, and there has been no systematic review of published adverse events. RBC transfusions continue to be linked to the development of morbidities unique to neonates, including chronic lung disease, retinopathy of prematurity, intraventricular haemorrhage and necrotising enterocolitis. Uncertainties about the exact nature of risks alongside benefits of RBC transfusion may contribute to evidence of widespread variation in neonatal RBC transfusion practice.Our review aims to describe clinical adverse effects attributed to small-volume (10-20 mL/kg) RBC transfusions and, where possible, their incidence rates in the neonatal population through the systematic identification of all relevant studies. METHODS: A comprehensive search of the following bibliographic databases will be performed: MEDLINE (PubMed
https://www.ndorms.ox.ac.uk/publications/482512
Delayed hemolytic transfusion reaction with hyperhemolysis after first red blood cell transfusion in child with beta...Delayed hemolytic transfusion reaction with hyperhemolysis after first red blood cell transfusion in child with beta...
BACKGROUND: Delayed hemolytic transfusion reaction (DHTR) can manifest with hyperhemolysis, a serious complication of red blood cell (RBC) transfusions. This has mostly been described in sickle cell anemia but occasionally in beta-thalassemia. Treatment is challenging; immunosuppressive medication has been reported to be useful by some but not others., CASE REPORT: A 1.5-year-old girl with homozygous beta-thalassemia was put on a regular RBC transfusion program because of anemia with stunted growth and abnormal bone development. After the first transfusion she developed DHTR with hyperhemolysis. Further RBC transfusions could not be avoided. Despite treatment with prednisone, immunoglobulins, rituximab, and azathioprine hemolysis continued. She received an allogeneic bone marrow transplantation after conditioning using cyclophosphamide, treosulfan, melfalan, and ATG. The transplantation was followed by treatment with cyclosporin A, methotrexate, and prednisone. Because of poor engraftment and ...
https://notifylibrary.org/reference/4381
The effects of iron deficiency on red blood cell transfusion requirements in non-bleeding critically ill patients.The effects of iron deficiency on red blood cell transfusion requirements in non-bleeding critically ill patients.
The effects of iron deficiency on red blood cell transfusion requirements in non-bleeding critically ill patients., Mustafa Said Aydogan, Muharrem Uçar, Aytaç Yücel, Bugra Karak
https://www.alliedacademies.org/articles/the-effects-of-iron-deficiency-on-red-blood-cell-transfusion-requirements-in-nonbleeding-critically-ill-patients.html
Red Blood Cell Transfusions for Pets - Bloody BrilliantRed Blood Cell Transfusions for Pets - Bloody Brilliant
Many dogs and cats may benefit from red blood cell transfusions. Learn more about their blood types and transfusion medicine by reading this blog post.
https://criticalcaredvm.com/red-blood-cell-transfusions-pets-bloody-brilliant/
Red Cell TransfusionRed Cell Transfusion
www.MOLUNA.de Red Cell Transfusion [4189914] - From Donor to Patient, Sandra J. Nance. Overview of Immunology, Nancy M. Heddle. Compatibility Testing For Red Blood Cell Components: Approaches and Limitations, Kathleen Sazama. Transfusion in the Face of Autoantibodies, Steven R. Sloan and Leslie E. Silberstein. Red Blood Cell Transfusion of the Immunocompromised Patient, Christopher P. Stowell. Red
https://www.moluna.de/buch/4189914-red+cell+transfusion/
Anaemia management with red Blood Cell transfusion to improve post-intensive care disability: a randomised controlled trial ...
Anaemia management with red Blood Cell transfusion to improve post-intensive care disability: a randomised controlled trial (The ABC post-intensive care trial ...
https://www.research.ed.ac.uk/en/projects/anaemia-management-with-red-blood-cell-transfusion-to-improve-pos
PRIME PubMed | Red blood cell transfusion for people undergoing hip fracture surgerPRIME PubMed | Red blood cell transfusion for people undergoing hip fracture surger
PubMed journal article Red blood cell transfusion for people undergoing hip fracture surger were found in PRIME PubMed. Download Prime PubMed App to iPhone, iPad, or Android
https://www.unboundmedicine.com/medline/citation/25897628/Red_blood_cell_transfusion_for_people_undergoing_hip_fracture_surgery_
Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease - Full Text View ...Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease - Full Text View ...
BACKGROUND:. Red blood cell transfusions are an extremely common medical intervention in both the United States and worldwide; over 14 million units of blood are transfused in the United States. Between 60 and 70 percent of all blood is transfused in the surgical setting. Despite the common use of red blood cell transfusions, the threshold for transfusion has not been adequately evaluated and is very controversial. A decade ago, the standard of care was to administer a peri-operative transfusion whenever the hemoglobin (Hgb) level fell below 10 g/dl (the 10/30 rule). Concerns about the safety of blood, especially with respect to HIV and hepatitis, and the absence of data to support a 10 g/dl threshold led to the current standard of care, which is to administer blood transfusions based on the presence of symptoms, and not a specific Hgb/hematocrit level. However, there have not been any randomized clinical trials done with surgical patients that have tested the efficacy and safety of ...
https://clinicaltrials.gov/ct2/show/NCT00071032?term=heart+attack&lup_s=06%2F13%2F2013&lup_d=14&show_rss=Y&sel_rss=mod14
Uptake | Blood transfusion | Guidance and guidelines | NICEUptake | Blood transfusion | Guidance and guidelines | NICE
Neoh, K.; Gray, R.; Grant-Casey, J.; et al. National comparative audit of red blood cell transfusion practice in hospices: Recommendations for palliative care practice, Palliative Medicine, 33, 1, 102-108, 2019. https://doi.org/10.1177/ ...
https://www.nice.org.uk/guidance/QS138/uptake
1072. Red blood cell transfusion in acute cerebral injuries: a systematic review of preclinical animal studies | Intensive Care...1072. Red blood cell transfusion in acute cerebral injuries: a systematic review of preclinical animal studies | Intensive Care...
We identified 6031 records and included 24 unique studies. Cerebrovascular injury models were used in 15 studies: stroke models (n=12), subarachnoid haemorrhage models (n=3). Traumatic brain injury models were used in 9 studies (trauma n=6, cryogenic lesion n=2, epidural lesion n=1). Twelve studies were performed using murine models. Most studies compared RBC transfusion to no transfusion (n=23) and used whole blood (n=21). Five studies reported data on mortality and 6 on neurological function; others reported surrogate endpoints such as cerebral blood flow. RBC transfusion was associated with decreased mortality in 3 of 5 (60%) studies reporting this outcome. In studies assessing neurological function, 2 of 6 studies favoured transfusion compared to no transfusion. No studies compared different transfusion thresholds. Hemodynamic and vital signs were not systematically reported in all studies. High risk of bias was observed in the majority (15/24, 58%) of studies (all studies reporting ...
https://icm-experimental.springeropen.com/articles/10.1186/2197-425X-2-S1-P88
Increased hospital costs associated with red blood cell transfusionIncreased hospital costs associated with red blood cell transfusion
Background - Red blood cell (RBC) transfusion is independently associated in a dose-dependent manner with increased intensive care unit stay, total hospital length of stay, and hospital-acquired complications. Since little is known of the cost of these transfusion-associated adverse outcomes our aim was to determine the total hospital cost associated with RBC transfusion and to assess any dose-dependent relationship. Study Design and Methods - A retrospective cohort study of all multiday acute care inpatients discharged from a five hospital health service in Western Australia between July 2011 and June 2012 was conducted. Main outcome measures were incidence of RBC transfusion and mean inpatient hospital costs. Results - Of 89,996 multiday, acute care inpatient discharges, 4805 (5.3%) were transfused at least 1 unit of RBCs. After potential confounders were adjusted for, the mean inpatient cost was 1.83 times higher in the transfused group compared with the nontransfused group (95% confidence ...
https://espace.curtin.edu.au/handle/20.500.11937/25356
Traumatic Brain Injury: Red Blood Cells TransfusionTraumatic Brain Injury: Red Blood Cells Transfusion
Most trauma deaths are related to traumatic brain injury (TBI). Although the management of patients has improved, mortality remains unacceptably high, and half of survivors of moderate and severe TBI are left with major functional impairment. Current management guidelines are based on limited evidence and practice is highly variable. Most acutely ill patients with TBI will develop anemia, which may decrease oxygen delivery to a fragile brain. While clinical practice is moving towards transfusing at low hemoglobin (Hb) levels, experts have expressed concerns regarding restrictive strategies, which may adversely affect clinical outcomes in TBI. Our primary objective is to evaluate the effect of red blood cell (RBC) transfusion thresholds on neurological functional outcome. We hypothesize that a liberal transfusion strategy improves outcomes compared to a restrictive strategy.
https://ichgcp.net/clinical-trials-registry/NCT03260478/
Transfusion Overload | PSNetTransfusion Overload | PSNet
Case Objectives Understand that the traditional transfusion thresholds of hemoglobin below 10 g/dL and hematocrit below 30% are not supported by the evidence. List the common serious adverse effects of transfusion. Describe the evidence supporting a more restrictive transfusion strategy. State what transfusion threshold should be used in hospitalized patients with and without coronary artery disease. Case & Commentary-Part 1:
https://psnet.ahrq.gov/web-mm/transfusion-overload
Impact of Early Red Blood Cell Transfusion After Kidney Transplantation on De Novo HLA Sensitization in the Setting of...Impact of Early Red Blood Cell Transfusion After Kidney Transplantation on De Novo HLA Sensitization in the Setting of...
Introduction:. HLA specific antibodies detection (HSA) and that of Donor Specific Antibodies (DSA) were revolutionized by the introduction of solid phase assays (Luminex®), therefore making these antibodies a powerful biomarker for humoral injuries to the allograft. Determinants of HSA development entail non-adherence to immunosuppressive drugs but also allosensitizing events such as red blood cell (RBC) transfusions. Recent works showed a higher incidence of DSA in transplanted patients following RBC transfusion events, but no specific data exist for AntiThymocyte Globulin (ATG) induction.. This work aims at assessing whether peri-transplant RBC transfusion resulted in post-transplant HLA sensitization, in the setting of ATG induction therapy.. Patients and methods:. All consecutive patients benefiting from a first ATG-induced kidney allograft between 2004 and 2014 at our center with no history of HLA immunization were included retrospectively, provided transfusion history and HSA history were ...
https://atcmeetingabstracts.com/abstract/impact-of-early-red-blood-cell-transfusion-after-kidney-transplantation-on-de-novo-hla-sensitization-in-the-setting-of-antithymocyte-globulin-induction/
Amgen Oncology Highlights Upcoming Data Presentations at the 2007 European Conference on Clinical OncologyAmgen Oncology Highlights Upcoming Data Presentations at the 2007 European Conference on Clinical Oncology
Increased the risk of death when administered to target a hemoglobin of 12 g/dL in patients with active malignant disease receiving neither chemotherapy or radiation therapy. ESAs are not indicated for this population. Patients receiving ESAs pre-operatively for reduction of allogeneic red blood cell transfusions: A higher incidence of deep venous thrombosis was documented in patients receiving Epoetin alfa who were not receiving prophylactic anticoagulation. Aranesp(R) is not approved for this indication.. Aranesp is contraindicated in patients with uncontrolled hypertension.. About Vectibix. Vectibix(TM) is indicated for the treatment of EGFr-expressing, metastatic colorectal cancer with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens.. The effectiveness of Vectibix for the treatment of EGFr-expressing, metastatic colorectal cancer is based on progression-free survival. Currently no data are available that demonstrate an ...
https://www.amgen.com/media/news-releases/2007/09/amgen-oncology-highlights-upcoming-data-presentations-at-the-2007-european-conference-on-clinical-oncology/
Episode 140: Transfusion Triggers and The TRICS 3 Trial with David Mazer - ACCRAC PodcastEpisode 140: Transfusion Triggers and The TRICS 3 Trial with David Mazer - ACCRAC Podcast
In this 140th episode I welcome Dr. David Mazer to the show. Dr. Mazer was the PI and first author on the TRICS 3 trial looking at liberal versus restrictive transfusion strategies in moderate to high risk cardiac surgery patients published in the NEJM in 2017. Dr. Mazer would like to add the following random recommendation: For a great combination of live jazz and good food and drinks in Toronto, check out the Jazz Bistro just up the street from St. Michaels Hospital.. Reference: https://www.nejm.org/doi/full/10.1056/NEJMoa1711818. Dr. Mazer can be reached at [email protected] ...
http://accrac.com/episode-140-transfusion-triggers-and-the-trics-3-trial-with-david-mazer/
RANDOMIZED CLINICAL TRIAL COMPARING LIBERAL AND RESTRICTIVE RED BLOOD CELLS TRANSFUSION STRATEGIES IN SEVERE TRAUMATIC BRAIN...RANDOMIZED CLINICAL TRIAL COMPARING LIBERAL AND RESTRICTIVE RED BLOOD CELLS TRANSFUSION STRATEGIES IN SEVERE TRAUMATIC BRAIN...
Anemia is frequent among traumatic brain injured (TBI) patients, and it is associated with an increased risk of poor outcomes. The optimal hemoglobin (Hb) level
https://www.cns.org/meetings/archived-abstracts-detail/congress-of-neurological-surgeons-2017-annual-meeting---late-breaking-science-23332
Red Blood Cell Transfusion | Annals of Internal Medicine | American College of PhysiciansRed Blood Cell Transfusion | Annals of Internal Medicine | American College of Physicians
The conundrum is what clinical factors should influence the routine titrated transfusion decision. The largest trial evaluating transfusion thresholds used prespecified symptoms (such as chest pain, orthostatic hypotension, or tachycardia unresponsive to fluid resuscitation) (1), which we included in our guideline. Although this approach is based on a randomized trial, these symptoms will not apply to all clinical settings. We agree with the accompanying editorial (2) that other variables (such as fatigue, dyspnea, mechanical ventilation, or the use of low Svo2) are unproven. Unfortunately, there is no evidence to support other important individual patient laboratory and physiologic variables as the basis for transfusion decisions ...
http://annals.org/aim/article-abstract/1392223/red-blood-cell-transfusion
TGF-β1 AND TNF-α AFTER RED BLOOD CELL TRANSFUSION IN COLORECTAL CANCER PATIENTS | Experimental oncologyTGF-β1 AND TNF-α AFTER RED BLOOD CELL TRANSFUSION IN COLORECTAL CANCER PATIENTS | Experimental oncology
Operations in patients with cancer are associated with blood transfusion to restore normal physiology. Blood transfusion can cause the immunomodulatory effect.
https://exp-oncology.com.ua/article/1297/tgf-946-1-and-tnf-945-after-red-blood-cell-transfusion-in-colorectal-cancer-patients?pdf
Supra-Plasma Expanders: The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions? - Fingerprint - Albert...Supra-Plasma Expanders: The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions? - Fingerprint - Albert...
Fingerprint Dive into the research topics of Supra-Plasma Expanders: The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions?. Together they form a unique fingerprint. ...
https://einstein.pure.elsevier.com/en/publications/supra-plasma-expanders-the-future-of-treating-blood-loss-and-anem/fingerprints/
A randomized study comparing leukocyte-depleted versus packed red cell transfusions in prospective cadaver renal allograft...A randomized study comparing leukocyte-depleted versus packed red cell transfusions in prospective cadaver renal allograft...
A randomized study comparing leukocyte-depleted versus packed red cell transfusions in prospective cadaver renal allograft recipients.
https://scholars.duke.edu/display/pub664480
Restrictive RBC transfusion strategy non-inferior to liberal approach in cardiac surgery - PACE-CMERestrictive RBC transfusion strategy non-inferior to liberal approach in cardiac surgery - PACE-CME
A restrictive RBC transfusion strategy with 7.5 g/dL as trigger was non-inferior to a strategy with 9.5 g/dL for mortality and major morbidity in patients undergoing cardiac surgery in TRICS III.
https://pace-cme.org/2017/11/13/restrictive-rbc-transfusion-strategy-non-inferior-to-liberal-approach-in-cardiac-surgery/
Quality statement 3: Reassessment after red blood cell transfusions | Blood transfusion | Quality standards | NICEQuality statement 3: Reassessment after red blood cell transfusions | Blood transfusion | Quality standards | NICE
Evidence-based statements to deliver quality improvements in the general principles of blood transfusion in adults, young people and children over 1 year old
https://www.nice.org.uk/guidance/qs138/chapter/quality-statement-3-reassessment-after-red-blood-cell-transfusions
Considerations for Use of Hematopoietic Growth Factors in Patients With Cancer Related to the COVID-19 Pandemic in: Journal of...Considerations for Use of Hematopoietic Growth Factors in Patients With Cancer Related to the COVID-19 Pandemic in: Journal of...
Blood supply shortages have been demonstrated in areas significantly impacted by pandemic infection.17 The American Association of Blood Banks has addressed suggestions to extend the blood supply in this context.18 More restrictive transfusion thresholds for red cell transfusion (eg, a threshold of ,7 g/dL) have been studied and found to be safe in the context of intensive care unit and hematopoietic stem cell transplant.19,20 Many centers have adopted this lower threshold for transfusion-dependent patients with hematologic and other malignancies to avoid blood shortages in the context of COVID-19. It is important to note that tolerance for this lower threshold may be limited in patients with coexisting cardiopulmonary or other conditions and that in these patients, a higher transfusion threshold or strategies to improve erythropoiesis, such as ESAs (including FDA-approved biosimilars), may be appropriate.. ESA (erythropoietin alfa and darbepoetin alfa) use for patients with cancer was ...
https://jnccn.org/view/journals/jnccn/aop/article-10.6004-jnccn.2020.7610/article-10.6004-jnccn.2020.7610.xml?rskey=2iZaqp&result=6
Postoperative red blood cell transfusion and morbid outcome in uncomplicated cardiac surgery patients | SpringerLinkPostoperative red blood cell transfusion and morbid outcome in uncomplicated cardiac surgery patients | SpringerLink
To evaluate postoperative red blood cell (RBC) transfusion and its association with postoperative cardiac events and multiorgan morbidity in uncomplicated cardiac surgery patients. A cohort of 945 pat
https://link.springer.com/article/10.1007%2Fs00134-010-2017-z
What is the evidence for using hemostatic agents in surgery?<...
TY - CHAP. T1 - What is the evidence for using hemostatic agents in surgery?. AU - Erstad, Brian L. PY - 2005. Y1 - 2005. N2 - The pharmacological methods used to achieve systemic hemostasis have generated much discussion due to concerns of serious adverse effects (e.g., thromboembolic complications) and costs of therapy in addition to efficacy considerations. There are a limited number of well-controlled trials involving pharmacological hemostasis for spine surgery. In the largest doubleblinded randomized controlled trial to date involving spine surgery, there was a trend toward reduced homologous transfusion in patients receiving aprotinin, but the only statistically significant result (p,0.001) was a reduction in autologous red cell donations. The findings of this trial are important, since the investigators used a number of restrictive transfusion strategies (e.g., autologous donation, low hematocrit trigger for transfusion, blood-salvaging procedures with the exception of no cell saver) ...
https://arizona.pure.elsevier.com/en/publications/what-is-the-evidence-for-using-hemostatic-agents-in-surgery-2
Hematocrit as a predictor of preoperative transfusion-associated complications in spine surgery: A NSQIP study. | Physicians...Hematocrit as a predictor of preoperative transfusion-associated complications in spine surgery: A NSQIP study. | Physicians...
Preoperative optimization of medical comorbidities prior to spinal surgery is becoming an increasingly important intervention in decreasing postoperative complications and ensuring a satisfactory postoperative course. The treatment of preoperative anemia is based on guidelines made by the American College of Cardiology (ACC), which recommends packed red blood cell transfusion when hematocrit is less than 21% in patients without cardiovascular disease and 24% in patients with cardiovascular disease. The literature has yet to quantify the risk profile associated with preoperative pRBC transfusion ...
https://www.physiciansweekly.com/hematocrit-as-a-predictor-of-preoperative-transfusion-associated-complications-in-spine-surgery-a-nsqip-study/
clinico | MedicalCRITERIA.comclinico | MedicalCRITERIA.com
The red blood cell transfusions should not be dictated by a single hemoglobin trigger but instead should be based on the patients risks of developing complications of inadequate oxygenation. Red blood cell transfusion is rarely indicated when the hemoglobin concentration is greater than 10 g/dL and is almost always indicated when it is less than 6 g/dL ...
http://medicalcriteria.com/web/tag/clinico/
Transfusion for hemoglobin above 7 g/dL: no benefit in septic shock (TRISS Trial) - PulmCCMTransfusion for hemoglobin above 7 g/dL: no benefit in septic shock (TRISS Trial) - PulmCCM
Blood transfusions have been a central component of protocols for care of severe sepsis and septic shock, ever since the single-center 2001 Rivers trial included them in its interventions. Any benefit (or harm) caused by red cell transfusion independently was unknowable, and so the therapy became standard care as part of the so-called sepsis bundle. The Surviving Sepsis guidelines have generally advised transfusion to a hematocrit of 30% or hemoglobin of 10 g/dL during the first 6 hours of septic shock if hypoperfusion (low central venous oxygenation) is present despite fluids and vasopressors.. However, the inclusion of red cell transfusion in sepsis bundles has been frequently challenged, based on the weak observational evidence for its benefit, compared to robust evidence from randomized trials showing transfusion above a hemoglobin of 7 g/dL is unhelpful generally. This finding has been shown in the critically ill (the TRICC trial), after hip surgery (FOCUS trial) and in non-critically ill ...
https://pulmccm.org/randomized-controlled-trials/transfusion-hemoglobin-7-gdl-benefit-septic-shock/
Conference Notes 9-10-2014 - ACMC EMConference Notes 9-10-2014 - ACMC EM
Experimenting with new format today. About 5 take home points for each lecture. Burns (visiting professor) Transfusion Safety. 1. In general, Less is More when you are considering transfusions. U.S. physicians transfuse more blood products than European and Canadian physicians due to individual practice variation being greater in the U.S. Recent studies have shown that increasing # of units transfused of any blood product correlates directly with increased mortality, length of stay and wound complications even when controlled for patients severity of illness.. 2. Patient outcomes are better with a transfusion threshold of HGB=7 rather than 8 or 10 unless a patient is having ACS. Harwood comment: Is 8 really better than 7 for ACS? Dr. Burns: Yes there is data that the mortality is less for ACS at a transfusion trigger of HGB=8 rather than 7. When you do transfuse, only transfuse a single unit and then re-assess before deciding to give a second unit.. 3. Transfusion trigger for normotensive upper ...
http://www.christem.com/acmcem-conf-notes/2014/9/10/conference-notes-9-10-2014.html
Guidelines on the management of anaemia and red cell transfusion in adult critically ill patients Clinical Practice GuidelinesGuidelines on the management of anaemia and red cell transfusion in adult critically ill patients Clinical Practice Guidelines
Definitions:. Strength of Recommendations. Strong (grade 1): Strong recommendations (grade 1) are made when there is confidence that the benefits do or do not outweigh harm and burden. Grade 1 recommendations can be applied uniformly to most patients. Regard as recommend.. Weak (grade 2): Where the magnitude of benefit or not is less certain a weaker grade 2 recommendation is made. Grade 2 recommendations require judicious application to individual patients. Regard as suggest.. Quality of Evidence. (A) High: Further research is very unlikely to change confidence in the estimate of effect. Current evidence derived from randomised clinical trials without important limitations.. (B) Moderate: Further research may well have an important impact on confidence in the estimate of effect and may change the estimate. Current evidence derived from randomised clinical trials with important limitations (e.g., inconsistent results, imprecision - wide confidence intervals or methodological flaws - e.g., ...
https://www.guidelinecentral.com/summaries/guidelines-on-the-management-of-anaemia-and-red-cell-transfusion-in-adult-critically-ill-patients/
MedStartrMedStartr
1) E.A. Hod , S.L. Spitalnik; 7 June 2012; Stored red blood cell transfusions: Iron, inflammation, immunity, and infection; Transfus Clin Biol. 19 (2012) 84-89. 2) Eldad A. Hod, Steven L. Spitalnik; 15 APR 2011; Harmful effects of transfusion of older stored red blood cells: iron and inflammation; DOI: 10.1111/j.1537-2995.2011.03096.x. 3) Niels Liona,b,⁎, David Crettaza, Olivier Rubina, Jean-Daniel Tissota 4 November 2009, Stored red blood cells: A changing universe waiting for its map(s); J Proteomics, 2010 Jan 3;73(3):374-85. 4) Eldad A. Hod, Gary M. Brittenham, Genia B. Billote, Richard O. Francis, Yelena Z. Ginzburg, Jeanne E. Hendrickson, Jeffrey Jhang, Joseph Schwartz, Shruti Sharma, Sujit Sheth, Anthony N. Sireci, Hannah L. Stephens, Brie A. Stotler, Boguslaw S. Wojczyk, James C. Zimring and Steven L. Spitalnik; October 20, 2011; Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non − transferrin-bound iron; Blood. 2011 ...
https://www.medstartr.com/project/detail/296
Changing indications for red cell transfusion. - Radcliffe Department of MedicineChanging indications for red cell transfusion. - Radcliffe Department of Medicine
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
https://www.rdm.ox.ac.uk/publications/191165
High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients<...High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients<...
TY - JOUR. T1 - High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients. AU - Sambasivan, Chitra N.. AU - Kunio, Nicholas R.. AU - Nair, Prakash V.. AU - Zink, Karen A.. AU - Michalek, Joel E.. AU - Holcomb, John B.. AU - Schreiber, Martin. PY - 2011/8. Y1 - 2011/8. N2 - Background: Administration of high transfusion ratios in patients not requiring massive transfusion might be harmful. We aimed to determine the effect of high ratios of fresh frozen plasma (FFP) and platelets (PLT) to packed red blood cells (PRBC) in nonmassively transfused patients. Methods: Records of 1,788 transfused trauma patients who received 1:2 ratio of FFP:PRBCs or a ,1:2 ratio PLT:PRBCs had significantly decreased ICU-free days and ventilator-free days. Conclusions: FFP:PRBC and PLT:PRBC ratios were not associated with in-hospital mortality. Depending on the threshold analyzed, a high ratio of FFP:PRBC and PLT:PRBC transfusion was associated with fewer ...
https://ohsu.pure.elsevier.com/en/publications/high-ratios-of-plasma-and-platelets-to-packed-red-blood-cells-do--2
American Association Of Veterinary Laboratory Diagnosticians | Anemia | Karl E. Jandrey, DVM, MAS, DAVCECC
The treatment of the anemic patient often requires accurate type and cross-matching of red blood cells and an effective adminstration plan. This lecture will focus on patient examplesand case-based discussions to understand which patient are good candidates for red blood cell transfusion, how to plan for appropriate transfusion therapy, and create a protocol for watchful administration. Transfusion reactions will be discussed and as well as the step on how to attempt to mitigate them.
https://www.wcea.education/app/aavld/elearning/veterinarian/american-association-of-veterinary-laboratory-diagnosticians/155616/anemia
Greater St. Louis Veterinary Medical Association | Anemia | Karl E. Jandrey, DVM, MAS, DAVCECC
The treatment of the anemic patient often requires accurate type and cross-matching of red blood cells and an effective adminstration plan. This lecture will focus on patient examplesand case-based discussions to understand which patient are good candidates for red blood cell transfusion, how to plan for appropriate transfusion therapy, and create a protocol for watchful administration. Transfusion reactions will be discussed and as well as the step on how to attempt to mitigate them.
https://www.wcea.education/app/stlouisvma/elearning/veterinarian/greater-st-louis-veterinary-medical-association/155616/anemia
Sublingual microcirculation does not reflect red blood cell transfusion thresholds in the intensive care unit-a prospective...Sublingual microcirculation does not reflect red blood cell transfusion thresholds in the intensive care unit-a prospective...
Hemoglobin (Hb) transfusion thresholds are established in intensive care units. A restrictive transfusion threshold (Hb 70-75 g/l) is recommended in septic patients, and a liberal transfusion threshold (Hb 90 g/l) for cardiogenic shock. It is unclear whether these historically adopted transfusion thresholds meet the challenges of individual patients. We evaluated microvascular flow index (MFI) and proportion of perfused vessels (PPV) in the sublingual microcirculation with CytoCam-IDF microscopy and near-infrared spectroscopy (NIRS). A study team-independent, treating intensivist assigned a total of 64 patients to 1 of 2 two transfusion thresholds, 43 patients to the Hb 75 g/l threshold and 21 patients to the Hb 90 g/l threshold, at a surgical intensive care unit. We performed microcirculatory measurements 1 h before and 1 h after transfusion of 1 unit of red blood cells. Microcirculatory flow variables correlated negatively with pre-transfusion flow variables (ΔMFI: ρ = − 0.821, p | 0.001; ΔPPV:
https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-2728-7/email/correspondent/c1/new
Duration of red blood cell storage and outcomes in pediatric cardiac surgery: an association found for pump prime blood.<...
TY - JOUR. T1 - Duration of red blood cell storage and outcomes in pediatric cardiac surgery. T2 - an association found for pump prime blood.. AU - Ranucci, Marco. AU - Carlucci, Concetta. AU - Isgrò, Giuseppe. AU - Boncilli, Alessandra. AU - De Benedetti, Donatella. AU - De la Torre, Teresa. AU - Brozzi, Simonetta. AU - Frigiola, Alessandro. PY - 2009. Y1 - 2009. N2 - INTRODUCTION: Cardiac surgery using cardiopulmonary bypass in newborns, infants and small children often requires intraoperative red blood cell transfusions to prime the circuit and oxygenator and to replace blood lost during surgery. The purpose of this study was to investigate the influence of red blood cell storage time prior to transfusion on postoperative morbidity in pediatric cardiac operations. METHODS: One hundred ninety-two consecutive children aged five years or less who underwent cardiac operations using cardiopulmonary bypass and who received red blood cells for priming the cardiopulmonary bypass circuit comprised ...
https://moh-it.pure.elsevier.com/en/publications/duration-of-red-blood-cell-storage-and-outcomes-in-pediatric-card
Anemia, red blood cell transfusions, and necrotizing enterocolitis<...
TY - JOUR. T1 - Anemia, red blood cell transfusions, and necrotizing enterocolitis. AU - Maheshwari, Akhil. AU - Patel, Ravi M.. AU - Christensen, Robert D.. PY - 2018/2/1. Y1 - 2018/2/1. N2 - In the past 15 years, multiple clinical studies have identified a temporal association between red blood cell (RBC) transfusions and necrotizing enterocolitis (NEC). With some variability, most of these studies indicate that up to one-third of all cases of NEC involving very low-birth weight infants may occur within 24-48 h after receiving a RBC transfusion. There is also evidence that the risk of such transfusion-associated NEC may be higher in infants transfused with the greatest severity of anemia. In this article, we summarize the clinical evidence pertaining to these issues; specifically, the contribution of RBC transfusions, and the contribution of severity of underlying anemia, to the pathogenesis of a type of NEC potentially termed, transfusion/anemia-associated NEC.. AB - In the past 15 years, ...
https://jhu.pure.elsevier.com/en/publications/anemia-red-blood-cell-transfusions-and-necrotizing-enterocolitis
Red blood cell concentrate transfusion strategies utilised at a tertiary-level paediatric intensive care unit: A descriptive...Red blood cell concentrate transfusion strategies utilised at a tertiary-level paediatric intensive care unit: A descriptive...
Red blood cell concentrate transfusion strategies utilised at a tertiary-level paediatric intensive care unit: A descriptive study on impact and cost
https://www.ajol.info/index.php/sajchh/article/view/183917/173274
Letter by Augoustides Regarding Article Aprotinin Does Not Increase the Risk of Renal Failure in Cardiac Surgery Patients |...Letter by Augoustides Regarding Article Aprotinin Does Not Increase the Risk of Renal Failure in Cardiac Surgery Patients |...
To the Editor:. I read with great interest the excellent article by Furnary and colleagues1 detailing an analysis of aprotinin and acute dialysis-dependent renal failure in cardiac surgery patients. Their multivariate analysis has demonstrated that increasing perioperative red blood cell transfusion, rather than aprotinin, is an independent risk factor for acute renal failure after cardiac surgery.. The data analysis as presented, however, does not account for angiotensin blockade in the presence of aprotinin, a described significant risk factor for perioperative renal injury.2 Consequently, if a significant percentage of the aprotinin cohort were exposed to angiotensin-converting enzyme inhibition, it might confound the results of the multivariate analysis. If the data for this variable are readily available, it would be interesting see if this potential confounder could have had any significant statistical effect.. Furthermore, the authors state in their discussion that meta-analysis of ...
http://circ.ahajournals.org/content/117/22/e474
Overuse of blood transfusions increases infection risk | Veterinary Sciences Tomorrow
by Vetscite. Blood transfusions are one of the most common procedures patients receive in the hospital but the more red blood cells they receive, the greater their risk of infection, says a new study led by the University of Michigan Heath System and VA Ann Arbor Healthcare System. Researchers analyzed 21 randomized controlled trials for the study that appears in Journal of the American Medical Association (JAMA). Elderly patients undergoing hip or knee surgeries were most susceptible, with a 30 percent lower risk of infection when fewer transfusions were used. Overall, for every 38 hospitalized patients considered for a red blood cell transfusion (RBC), one patient would be spared a serious infection if fewer transfusions were used. Transfusions are often used for anemia or during surgery to make up for blood loss. The authors evaluated all health care-associated infections that were reported after receiving donor blood in the randomized trials. These included serious infections such as ...
http://vetscite.org/2014/04/overuse-of-blood-transfusions-increases-infection-risk/
Abstract 14026: The Impact of Hemoglobin Drop, Bleeding Events and Blood Transfusion on Long Term Mortality Following...Abstract 14026: The Impact of Hemoglobin Drop, Bleeding Events and Blood Transfusion on Long Term Mortality Following...
Background: Despite the minimally invasive nature of trans-catheter aortic valve implantation (TAVI), the procedure is associated with several complications. We analyzed the individual impact of bleeding events, hemoglobin (Hb) drop, and Red Blood Cells (RBC) transfusions on prognosis.. Methods and results: Consecutive patients (n=597) undergoing trans-femoral TAVI were prospectively enrolled. Peri-procedural Hb levels, RBC transfusions and major/life threatening bleeding events were documented and analyzed. To study the relationship between Hb drop, RBC transfusions and long-term mortality, the entire cohort was divided into 4 groups according to Hb drop (less or ≥ than 3 g/dl), and receiving RBC transfusion (yes /no). In the entire cohort mean Hb level decreased following TAVI (11.8±1.4 to 9.5 ±1.3 g/dl; p,0.001). Major/ life threatening bleedings occurred in 66 (10.1%) patients, and 179 (30%) patients received RBC transfusions. Major/life threatening bleedings were not independently ...
http://circ.ahajournals.org/content/132/Suppl_3/A14026
Penn Vet | Clinical Trial - Effect of duration of red blood cell storage on transfusion-associated inflammation in dogs with...
The shelf-life of stored red blood cells (RBCs) is typically 42 and 35 days for human and canine RBCs, respectively. Given that blood is a precious and limited resource, both human and veterinary blood banks typically dispense the oldest RBC units first to reduce wastage. However, accumulating evidence suggests that transfusion of RBCs stored ≥ 14 days is associated with increased rates of morbidity and mortality in hospitalized human patients. In our study of healthy dogs receiving autologous RBC transfusions stored for 7 (fresh) and 28 (old) days, administration of old, but not fresh, RBC units was associated with a pro-inflammatory cytokine response, exemplified by monocyte chemoattractant protein (MCP)-1, and accompanied by increased neutrophil counts and decreased platelet counts.. We propose to evaluate markers of inflammation, hemolysis, and endothelial activation in a randomized clinical trial in which client-owned dogs with primary immune-mediated hemolytic anemia (IMHA) and ...
http://www.vet.upenn.edu/research/clinical-trials/penn-vet-clinical-trials/clinical-trial/effect-of-duration-of-red-blood-cell-storage-on-transfusion-associated-inflammation-in-dogs-with-imha-and-imt
Defining transfusion triggers and utilization of fresh frozen plasma and platelets among patients undergoing...
TY - JOUR. T1 - Defining transfusion triggers and utilization of fresh frozen plasma and platelets among patients undergoing hepatopancreaticobiliary and colorectal surgery. AU - Ejaz, Aslam. AU - Frank, Steven M.. AU - Spolverato, Gaya. AU - Kim, Yuhree. AU - Pawlik, Timothy M.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Background: We sought to define the overall utilization of fresh frozen plasma (FFP) and platelets and the impact on perioperative outcomes among patients undergoing hepatopancreaticobiliary and colorectal resections, as well as analyze the utility of laboratory triggers in guiding transfusion practice. Methods: We identified 3027 patients undergoing pancreatic, hepatic, and colorectal resections between 2010 and 2013 at Johns Hopkins Hospital. Data on international normalized ratio (INR) and platelet counts that triggered the perioperative utilization of these non-RBC (red blood cell) products were obtained and analyzed. Results: Overall FFP and platelet transfusion rates were 8.9% ...
https://jhu.pure.elsevier.com/en/publications/defining-transfusion-triggers-and-utilization-of-fresh-frozen-pla-6
The Outcome of Preoperative Transfusion Guideline on Sickle Cell Disease Patients at King Fahd Hospital-Jeddah (KSA) | Open...The Outcome of Preoperative Transfusion Guideline on Sickle Cell Disease Patients at King Fahd Hospital-Jeddah (KSA) | Open...
Background: We developed a local hospital preoperative transfusion guideline for sickle cell disease (SCD) patients to reduce the perioperative and the postoperative comp..
https://www.omicsonline.org/open-access/the-outcome-of-preoperative-transfusion-guideline-on-sickle-cell-diseasepatients-at-king-fahd-hospitaljeddah-ksa-2155-9864-1000381.php?aid=88738
Blood Transfusion Guidelines | Atlantic Provinces Pediatric Hematology Oncology NetworkBlood Transfusion Guidelines | Atlantic Provinces Pediatric Hematology Oncology Network
Les directives sur les soinsde soutien ont été mises au point par des spécialistes en santé qualifiés des provinces atlantiques (médecins, pharmaciens, personnel infirmier et autres professionnels de santé) à laide de références fondées sur les preuves ou sur les pratiques exemplaires. Le format et le contenu des directives seront modifiés à loccasion dexamens et de révisions périodiques. Nous avons pris soin dassurer lexactitude de linformation. Toutefois, tout médecin ou professionnel de santé utilisant ces directives sera responsable de la vérification des doses et de ladministration des médicaments conformément aux formulaires, aux politiques et aux normes de soins reconnues au sein de son établissement.. Link to APPHON/ROHPPA French translated Blood Transfusion Guideline. The C17 Council is an organization composed of the institutionally appointed heads of the sixteen pediatric hematology, oncology, and stem cell transplant programs across Canada. They represent ...
http://apphon-rohppa.com/fr/blood-transfusion-guidelines
The Impact of Uncross-Matched Blood Transfusion on the Need for Massive Transfusion and Mortality: Analysis of 5,166 Uncross...
The Impact of Uncross-Matched Blood Transfusion on the Need for Massive Transfusion and Mortality: Analysis of 5,166 Uncross-Matched Units Academic Article ...
https://experts.mcmaster.ca/display/publication707445
The impact of an hematocrit of 20% during normothermic cardiopulmonary bypass for elective low risk coronary artery bypass...The impact of an hematocrit of 20% during normothermic cardiopulmonary bypass for elective low risk coronary artery bypass...
Cardiopulmonary bypass (CPB) induces hemodilutional anemia, which frequently requires the transfusion of blood products. The objective of this study was to evaluate oxygen delivery and consumption and clinical outcome in low risk patients who were allocated to an hematocrit (Hct) of 20% versus 25% during normothermic CPB for elective coronary artery bypass graft (CABG) surgery. This study was a prospective, randomized and controlled trial. Patients were subjected to normothermic CPB (35 to 36°C) and were observed until discharge from the intensive care unit (ICU). Outcome measures were calculated whole body oxygen delivery, oxygen consumption and clinical outcome. A nonparametric multivariate analysis of variance for repeated measurements and small sample sizes was performed. In a total of 54 patients (25% Hct, n = 28; 20% Hct, n = 26), calculated oxygen delivery (p = 0.11), oxygen consumption (p = 0.06) and blood lactate (p = 0.60) were not significantly different between groups. Clinical outcomes
https://ccforum.biomedcentral.com/articles/10.1186/cc4891
Results of a protocol of transfusion threshold and surgical technique on transfusion requirements in burn patients<...
TY - JOUR. T1 - Results of a protocol of transfusion threshold and surgical technique on transfusion requirements in burn patients. AU - OMara, Michael S.. AU - Hayetian, Fernando. AU - Slater, Harvey. AU - Goldfarb, I. William. AU - Tolchin, Eric. AU - Caushaj, Philip F.. PY - 2005/8/1. Y1 - 2005/8/1. N2 - Introduction: Blood loss and high rates of transfusion in burn centers remains an area of ongoing concern. Blood use brings the risk of infection, adverse reaction, and immunosuppression. Methods: A protocol to reduce blood loss and blood use was implemented. Analysis included 3-year periods before and after institution of the protocol. All patients were transfused for a hemoglobin below 8.0 gm/dL. Results: Operations per admission did not change during the two time periods (0.78 in each). Overall units transfused per operation decreased from 1.56 ± 0.06 to 1.25 ± 0.14 units after instituting the protocol (p , 0.05). Also, units transfused per admission decreased from 1.21 ± 0.15 to 0.96 ...
https://utsouthwestern.pure.elsevier.com/en/publications/results-of-a-protocol-of-transfusion-threshold-and-surgical-techn
Individual Probability of Allogeneic Erythrocyte Transfusion in Elective Spine Surgery:The Predictive Model of Transfusion in...Individual Probability of Allogeneic Erythrocyte Transfusion in Elective Spine Surgery:The Predictive Model of Transfusion in...
Patients scheduled to undergo elective spine surgery were included. More than 50% of the patients had an American Society of Anesthesiologists physical status of II or III. Exclusion criteria were exclusive cervical spine surgery, one-level laminectomy, and polytrauma. Clinical management was at the discretion of the attending anesthesiologists and surgeons. In the operating room, patients were continuously monitored with electrocardioscopy, blood pressure monitoring, pulse oximetry, capnography, and esophageal temperature monitoring. A Bair Hugger device (Arizant, Eden Prairie, MN) was used, and fluids were warmed. Anesthesia was induced with propofol (1.5-2.5 mg/kg), sufentanil (15 μg), and atracurium (0.7 mg/kg) and was maintained by a continuous infusion of sufentanil and atracurium, with desflurane in a 50%-50% vol/vol O2-N2O gas mixture. The rate of the sufentanil infusion and the inspired concentration of desflurane were adjusted to maintain mean blood pressure between 50 and 70 mm Hg ...
http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1923878
Effects of erythrocytapheresis transfusion on the viscoelastic...Effects of erythrocytapheresis transfusion on the viscoelastic...
Effects of erythrocytapheresis transfusion on the viscoelasticity of sickle cell blood.: Red blood cells containing hemoglobin S are less deformable than normal
https://www.mysciencework.com/publication/show/effects-erythrocytapheresis-transfusion-viscoelasticity-sickle-cell-blood-d17ce30e
Results for: Subject:Erythrocyte Transfusion | EthicShare CommunityResults for: Subject:Erythrocyte Transfusion | EthicShare Community
Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege / Deutsche Gesellschaft für Sozialpädiatrie und Deutsche Gesellschaft für Kinderheilkunde ...
http://ethicshare.org/publications/?subject=Erythrocyte%20Transfusion&sc=advanced
2018 ICD-10-CM Diagnosis Code E83.111: Hemochromatosis due to repeated red blood cell transfusions2018 ICD-10-CM Diagnosis Code E83.111: Hemochromatosis due to repeated red blood cell transfusions
Free, official coding info for 2018 ICD-10-CM E83.111 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
http://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E83-/E83.111
Systematic Review and Meta-Analysis of Platelet Transfusion Data - Transfusion NewsSystematic Review and Meta-Analysis of Platelet Transfusion Data - Transfusion News
In the United States, over two million patients receive platelet transfusions each year either prophylactically to reduce the risk of bleeding or therapeutically to control active bleeding.. A new systematic review from 17 randomized clinical trials and 55 observational studies summarizes the platelet transfusion literature focusing on dosage, transfusion thresholds and clinical conditions. The new AABB platelet transfusion guidelines are based on this systematic review. The systematic review also highlights that further research, especially for invasive procedures, is needed to optimize the transfusion of platelets.. References ...
http://transfusionnews.com/2015/05/29/systematic-review-and-meta-analysis-of-platelet-transfusion-data/
Duration of red blood cell storage and survival of transfused patients (CME) - PublicationlistASMDuration of red blood cell storage and survival of transfused patients (CME) - PublicationlistASM
Disquieting reports of increased complication and death rates after transfusions of red blood cells (RBCs) stored for more than 14 days prompted us to perform an observational retrospective cohort study of mortality in relation to storage time ...
https://publichealth.ku.dk/about-the-department/social/publications/publicationlistasm/?pure=en%2Fpublications%2Fduration-of-red-blood-cell-storage-and-survival-of-transfused-patients-cme
Duration of red blood cell storage and survival of transfused patients (CME) - StaffDuration of red blood cell storage and survival of transfused patients (CME) - Staff
Disquieting reports of increased complication and death rates after transfusions of red blood cells (RBCs) stored for more than 14 days prompted us to perform an observational retrospective cohort study of mortality in relation to storage time ...
https://publichealth.ku.dk/staff/?pure=en%2Fpublications%2Fduration-of-red-blood-cell-storage-and-survival-of-transfused-patients-cme
Myelodysplastic SyndromeMyelodysplastic Syndrome
Doctors are still working on a cure for MDS, though there are many ways to manage the disease. Patients with very low risk who do not need blood transfusions may be able to go without treatment for years, as long as they are checked regularly by a doctor. Other patients need more aggressive therapies. One treatment regimen that has worked for some patients is high doses of chemotherapy followed by a stem cell transplant. Other MDS treatments aim to reduce the need for blood transfusions, decrease the risk of infection and increase quality of life.. Blood transfusions - Some patients may need red cell to relieve symptoms of fatigue and shortness of breath. Blood transfusions increase the number of normal red blood cells in circulation, helping to relieve anemia. Platelet transfusions may be given to prevent or stop bleeding if platelet counts are very low.. During a transfusion, a technician will hang a bag containing the blood product you are receiving from a pole, then insert a narrow tube into ...
https://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/myelodysplastic_syndrome.html
Effect of blood transfusion on recurrence of head and neck carcinoma : retrospective review and meta-analysis. | Base...
To study the effect of transfusion on recurrence of squamous cell carcinoma of the head and neck, we analyzed the records of 143 patients with stage 11 through N squamous cell carcinoma of the supraglottic larynx or hypopharynx for whom follow-up to recurrence or 5 years after surgical therapy was available. Variables studied were age, gender,...
http://www.bdsp.ehesp.fr/Base/60986/
TRISS - Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive...TRISS - Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive...
Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled ...
https://ctu.dk/clinical-trial-posts/2011/triss-transfusion-requirements-in-septic-shock-triss-trial-comparing-the-effects-and-safety-of-liberal-versus-restrictive-red-blood-cell-transfusion-in-septic-shock-patients-in-the-intensive-car/
Which is worse? Anemia or transfusion? - Manuel Fontes, MD | DUKEHealth JAWhich is worse? Anemia or transfusion? - Manuel Fontes, MD | DUKEHealth JA
At the conclusion of this activity, participants should be able to:. • Understand acute anemia vs. chronic anemia. • Understand concerns of Liberal vs. Restrictive transfusion.. • Understand red blood cell storage lesions ...
https://ja.dh.duke.edu/content/which-worse-anemia-or-transfusion-manuel-fontes-md
Are blood transfusions from younger or female donors riskier? - ABC6 - Providence, RI and New Bedford, MA News, WeatherAre blood transfusions from younger or female donors riskier? - ABC6 - Providence, RI and New Bedford, MA News, Weather
HealthDay News) -- Red blood cell transfusions from young or female donors may lead to lower survival rates for recipients, according to a new Canadian study.. These results are intriguing and suggest that if you require a transfusion, your clinical outcome may be affected by the blood donors age and sex, said the studys senior author, Dr. Dean Fergusson. Hes director of the clinical epidemiology program at the Ottawa Hospital in Canada.. However, it is important to remember that our study was observational in nature, which means it cannot be considered definitive evidence, Fergusson said.. The researchers looked at blood transfusions at Ottawa Hospital between 2006 and 2013. The researchers linked more than 30,000 blood recipients with almost 81,000 donors.. The recipients health was followed for an average of just over two years.. Getting red blood cells from a woman instead of a man was linked with an 8 percent greater risk of death from any cause per unit of blood transfused, the ...
http://www.abc6.com/story/32417696/are-blood-transfusions-from-younger-or-female-donors-riskier
Transfusion of banked red blood cells and the effects on hemorrheology and microvascular hemodynamics in anemic hematology...Transfusion of banked red blood cells and the effects on hemorrheology and microvascular hemodynamics in anemic hematology...
BACKGROUND: The aim of this study was to investigate the effects of red blood cell (RBC) transfusion on the hemorrheologic properties and microcirculatory hemodynamics in anemic hematology outpatients receiving 2 to 4 RBC units of either fresh (leukoreduced storage for less than 1 week) or aged (leukoreduced storage for 3-4 weeks) RBCs.. STUDY DESIGN AND METHODS: Measurements were performed before and 30 minutes after RBC transfusion in hematology outpatients. Leukoreduced RBC suspensions were stored in saline-adenine-glucose-mannitol (SAGM) additive solution. Whole blood viscosity was measured using Couette low-shear viscometry, RBC deformability and aggregability were measured using laser-assisted optical rotational cell analysis, and microcirculatory density and perfusion were assessed using sidestream dark field imaging.. RESULTS: One group of patients (n = 10) received a median (interquartile range) of 3 (2-3) RBC bags that were stored for 7 (5-7) days (fresh) and the other group of ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1537-2995.2012.03905.x/full
Use of blood transfusions may be halved for patients with blood poisoning | Department of Clinical Medicine | UiBUse of blood transfusions may be halved for patients with blood poisoning | Department of Clinical Medicine | UiB
K1s Anne Berit Guttormsen and Brit Sjøbø from Haukeland University Hospital, published together with Nordic colleagues an article in the leading medical journal The New England Journal of Medicine which shows that blood transfusions can be halved in patients with sepsis.
https://www.uib.no/en/k1/81651/use-blood-transfusions-may-be-halved-patients-blood-poisoning
Does erythrocyte blood transfusion prevent acute kidney injury? Propensity-matched case control analysis.
BACKGROUND: Acute kidney injury is a common occurrence in intensive care unit patients with a reported incidence of 11-67% and is associated with an increased risk of death. In other patient populations, erythrocyte transfusion has been associated wi
http://www.biomedsearch.com/nih/Does-Erythrocyte-Blood-Transfusion-Prevent/20966666.html
NCCN Guidelines for Patients® | Myelodysplastic SyndromesNCCN Guidelines for Patients® | Myelodysplastic Syndromes
43 NCCN Guidelines for Patients ® : Myelodysplastic Syndromes, 2018 5 Treatment guide Lower-risk MDS with anemia The goal is to increase red blood cell counts and lessen the need for red blood cell transfusions. Doctors often assess the response about 2 to 4 months after the start of treatment with lenalidomide. If tests do not show a treatment response, then your next options are the same as those listed for MDS without del(5q). If tests show a response, you should continue this treatment until it stops working or side effects get too severe. Over time, your doctor may lower the dose of lenalidomide to lessen the side effects. (See page 33 for more details about lenalidomide.) Treatment options for MDS without del(5q) If tests show serum EPO ≤500 mU/mL, treatment with blood cell growth factors is recommended. The two main options are epoetin alfa and darbepoetin alfa. These drugs are red blood cell growth factors- also called ESAs. ESAs act like EPO and stimulate the body to make more red ...
https://www.nccn.org/patients/guidelines/mds/45/
EPOGEN® treatment for patients with anemia due to chronic kidney disease (CKD) | EPOGEN® (epoetin alfa)EPOGEN® treatment for patients with anemia due to chronic kidney disease (CKD) | EPOGEN® (epoetin alfa)
EPOGEN® (epoetin alfa) is used to treat a lower than normal number of red blood cells (anemia) caused by chronic kidney disease in patients on dialysis to reduce or avoid the need for red blood cell transfusions.
http://www.epogen.com
WHO | 10 facts on blood transfusionWHO | 10 facts on blood transfusion
Often transfusions are prescribed when simple and safe alternative treatments might be equally effective. As a result such a transfusion may not be necessary. An unnecessary transfusion exposes patients to the risk of infections such as HIV and hepatitis and adverse transfusion reactions.. ...
http://who.int/features/factfiles/blood_transfusion/blood_transfusion/en/index9.html
AABB Guidelines: RBC transfusion thresholds & storage | MDedge Hematology and OncologyAABB Guidelines: RBC transfusion thresholds & storage | MDedge Hematology and Oncology
Copyright © 2020 Frontline Medical Communications Inc., Parsippany, NJ, USA. All rights reserved. Unauthorized use prohibited. The information provided is for educational purposes only. Use of this Web site is subject to the medical disclaimer.. ...
https://www.mdedge.com/hematology-oncology/quiz/3927/clinical-guidelines/aabb-guidelines-rbc-transfusion-thresholds-storage?channel=306
Massive transfusion - Oxford MedicineMassive transfusion - Oxford Medicine
♦ Treatment of anaemia has changed substantially since the early 1990s♦ Although massive transfusion may be necessary, trauma surgeons have modified their practice to provide aggressive control of haemorrhage, prevent hypothermia and acidosis, optimize haemodynamic management in intensive care units, and rationalize transfusion support in severely injured patients. The result has been an improvement in the outcomes of these patients♦ Given the importance of early intervention in the care of the injured, understanding the physiology and true indications for early massive transfusion in trauma care has the potential to save many lives.
https://oxfordmedicine.com/view/10.1093/med/9780199550647.001.0001/med-9780199550647-chapter-012005
Josefs Story : JosefWood.com
Finally, after months of waiting & hoping, Josef was diagnosed with idiopathic aplastic anemia. To date, in the last 8 months, hes had about 23 platelet transfusions & 8 red blood cell transfusions. We tried steroids twice in 5 day bouts, with no change except in his white cell count a little. After numerous times in the hospital attempting to put in an IV and having his veins burst due to the low platelets, we decided to graduate to a more secure mode; he had surgery to put in a port for his transfusions. Around this time we began seeing a naturopath/chiropractic on a weekly basis. She began adjusting Josef every week, put him on a strict gluten-free, low sugar, organic diet, and got him on a herb/supplement regimen. We tried to treat his body naturally but ran short on time due to the iron overload concern. A couple months later we finally had to move ahead with a treatment plan. In April 2008 we underwent an immunosuppresive therapy of ATG, cyclosporin & prednisone (chemotherapy). While ...
http://josefwood.com/?page_id=22
Luspatercept Effective in Patients with Lower-Risk Myelodysplastic Syndromes
Pivotal phase 3 data demonstrated treatment with luspatercept resulted in statistically significant increased red blood cell transfusion independence compared with placebo.
http://theoncologynurse.com/ton-web-exclusives/18006-luspatercept-effective-in-patients-with-lower-risk-myelodysplastic-syndromes
Immune Mediated Hemolytic Anemia - Find a Vet SpecialistImmune Mediated Hemolytic Anemia - Find a Vet Specialist
Hospitalization, possibly with intensive care and red blood cell transfusions, may be necessary depending on the severity of the disease process. Supplemental oxygen therapy may be necessary. Your veterinarian may discuss discontinuing any recent medications which could trigger IMHA. If an infection is suspected, an appropriate medication for the infection will be given. High doses of steroid medications (such as prednisone or dexamethasone) are commonly given to help control the immune attack on the red blood cells. Additional immunosuppressive drugs may also be needed, especially in more severe cases. Because the red blood cell destruction can result in blood clots, anticoagulant drugs like aspirin may be needed. Newer advanced treatments like blood purification are being investigated and are sometimes recommended in severe cases.. Once immunosuppressive therapy is started, response to treatment is expected within 1 to7 days if the medications are effective. Additional medications are often ...
http://vetspecialists.com/immune-mediated-hemolytic-anemia/
AMs Story - Transformed follicular treated with SCT including HD Bexxar
I was supposed to have had an exit interview to be released from SCCA on Friday, October 10, which was subsequently changed to Monday, October 13. However, my neutrophil counts have been bouncing around. From over 1.0, they fell to .56 last Friday (almost neutropenic), but bounced back up to .95 a day or two later. My platelet count has been steadily declining to 12,000 on Friday, but it bounced up to 20,000 a day later and then started falling again. Dr. Holmberg consequently indicated I should stay in Seattle and be monitored at SCCA another couple of weeks to October 24. She prescribed G-CSF yesterday, which brought my neutrophil and white count up to the normal range today. I also received a red blood cell transfusion today because my hematocrit had dropped to 26%. Although, it was up to 27% today before the transfusion, it has slowly but consistently trended downward. I also received today an IL-11 (Neumega) shot to encourage platelet growth. The dosage was based on body weight, and I ...
http://lymphomation.org/story-AM-hdbexxar-SCT.htm
GYPEGYPE
"Entrez Gene: GYPE glycophorin E". Cartron JP, Rahuel C (1992). "Human erythrocyte glycophorins: protein and gene structure ... analyses". Transfusion Medicine Reviews. 6 (2): 63-92. doi:10.1016/S0887-7963(92)70158-8. PMID 1591491. Huang CH, Skov F, ...
https://en.wikipedia.org/wiki/GYPE
Coombs testCoombs test
"13.3: Pre-transfusion testing". www.transfusionguidelines.org. Joint United Kingdom (UK) Blood Transfusion and Tissue ... Reid ME, Lomas-Francis C (23 December 2015). "Chapter 136: Erythrocytes Antigens and Antibodies". Williams hematology (9th ed ... Donor blood for transfusion is also screened for infections in separate processes.[citation needed] Antibody screening A blood ... The indirect Coombs test is used in prenatal testing of pregnant women and in testing prior to a blood transfusion. The test ...
https://en.wikipedia.org/wiki/Coombs_test
Red blood cellRed blood cell
... and the erythrocyte sedimentation rate. The blood type needs to be determined to prepare for a blood transfusion or an organ ... Red blood cells may be given as part of a blood transfusion. Blood may be donated from another person, or stored by the ... Database of vertebrate erythrocyte sizes. Red Gold, PBS site containing facts and history (CS1 maint: uses authors parameter, ... Before blood is given, a small sample of the recipient's blood is tested with the transfusion in a process known as cross- ...
https://en.wikipedia.org/wiki/Red_blood_cell
Glycophorin AGlycophorin A
... created by attaching peptides onto erythrocytes". Transfusion. 50 (3): 635-641. doi:10.1111/j.1537-2995.2009.02480.x. PMID ... The erythrocyte binding antigen 175 of P. falciparum recognises the terminal Neu5Ac(alpha 2-3)Gal-sequences of glycophorin A. ... V) human erythrocytes". Eur. J. Biochem. 184 (2): 337-44. doi:10.1111/j.1432-1033.1989.tb15024.x. PMID 2792104. Tate CG, Tanner ... 2002). "Transfusion support with RBCs from an Mk homozygote in a case of autoimmune hemolytic anemia following diphtheria- ...
https://en.wikipedia.org/wiki/Glycophorin_A
Alexander VinokourovAlexander Vinokourov
His blood had a double population of erythrocytes, which implied a homologous transfusion. He delivered a positive for blood ... "Vinokourov positive for transfusion, Astana quits Tour". Cyclingnews. 25 July 2007. VeloNews , Thursday's EuroFile: Light Vino ...
https://en.wikipedia.org/wiki/Alexander_Vinokourov
KodevirionKodevirion
... created by attaching peptides onto erythrocytes". Transfusion. 50 (3): 635-641. doi:10.1111/j.1537-2995.2009.02480.x. PMID ... Oliver C, Blake D, Henry S (2011). "In vivo neutralization of anti-A and successful transfusion of A antigen incompatible red ... Oliver C, Blake D, Henry S (2011). "Modeling transfusion reactions and predicting in vivo cell survival with kodecytes". ... Transfusion. 51 (8): 1723-1730. doi:10.1111/j.1537-2995.2010.03034.x. PMID 21303367. Hadac EM, Federspiel MJ, Chernyy E, ...
https://en.wikipedia.org/wiki/Kodevirion
Hemolytic disease of the newborn (anti-Kell)Hemolytic disease of the newborn (anti-Kell)
IUT - Intrauterine Transfusion (IUT) is done either by intraperitoneal transfusion (IPT) or intravenous transfusion (IVT). IVT ... Erythrocyte Alloimmunization and Pregnancy at eMedicine "UpToDate". www.uptodate.com. Hemolytic Disease of Newborn~treatment at ... Hemolytic Disease of Newborn~followup at eMedicine Strobel, Erwin (2008). "Hemolytic Transfusion Reactions". Transfusion ... Exchange transfusion - Exchange transfusion is used when bilirubin reaches either the high or medium risk lines on the nonogram ...
https://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn_(anti-Kell)
Automated analyserAutomated analyser
Automatic erythrocyte sedimentation rate (ESR) readers, while not strictly analysers, do preferably have to comply to the 2011- ... Recent developments include automation for the immunohaematology lab, also known as transfusion medicine. These are used to ... "ICSH review of the measurement of the erythrocyte sedimentation rate", both indicating the only reference method, being ... published CLSI (Clinical and Laboratory Standards Institute) "Procedures for the Erythrocyte Sedimentation Rate Test: H02-A5 ...
https://en.wikipedia.org/wiki/Automated_analyser
Ozzie (gorilla)Ozzie (gorilla)
Antigenic Determinants on Gorilla Erythrocytes". Transfusion. 11 (5): 270-280. doi:10.1111/j.1537-2995.1971.tb04414.x. PMID ...
https://en.wikipedia.org/wiki/Ozzie_(gorilla)
Induced stem cellsInduced stem cells
... stem cell-derived erythrocytes as upcoming players in blood transfusion". Stem Cells. 30 (8): 1587-96. doi:10.1002/stem.1136. ... RBC transfusion is necessary for many patients. However, to date the supply of RBCs remains labile. In addition, transfusion ... Transfusion of in vitro-generated RBCs or erythroblasts does not sufficiently protect against tumor formation. The aryl ... Thon JN, Medvetz DA, Karlsson SM, Italiano JE (June 2015). "Road blocks in making platelets for transfusion". Journal of ...
https://en.wikipedia.org/wiki/Induced_stem_cells
GYPBGYPB
Raddon has been associated with severe transfusion reactions. Glycophorin B acts as a receptor for erythrocyte binding Ligand ( ... Baldwin ML, Barrasso C, Gavin J (1981). "The first example of a Raddon-like antibody as a cause of a transfusion reaction". ... Both anti-S and anti-s have been implicated in transfusion reactions and haemolytic disease of the newborn. Anti-M although ... There are ~80000 copies of glycophorin B per erythrocyte. Both glycophorin A and B are expressed on the renal endothelium and ...
https://en.wikipedia.org/wiki/GYPB
Giulio BizzozeroGiulio Bizzozero
In 1881 he described platelets as a third element in blood after the erythrocytes and leucocytes. Platelets had been described ... In 1869 he noted the value of blood transfusions in treating anemia. ...
https://en.wikipedia.org/wiki/Giulio_Bizzozero
Jack L. StromingerJack L. Strominger
Graft acceptance or rejection was only hinted at through previous knowledge of Blood type erythrocyte transfusion. In the mid- ...
https://en.wikipedia.org/wiki/Jack_L._Strominger
Function-spacer-lipid Kode constructFunction-spacer-lipid Kode construct
... created by attaching peptides onto erythrocytes". Transfusion. 50 (3): 635-641. doi:10.1111/j.1537-2995.2009.02480.x. PMID ... "Modeling transfusion reactions with kodecytes and enabling ABO incompatible transfusion with Function-Spacer-Lipid constructs ... Chesla, S; Henry, S; Eatz, R; Sinor, L (2010). "Solid phase syphilis test utilizing KODE technology". Transfusion. 50: 196A- ... Oliver, Caroline; Blake, Debbie; Henry, Stephen (2011). "In vivo neutralization of anti-A and successful transfusion of A ...
https://en.wikipedia.org/wiki/Function-spacer-lipid_Kode_construct
Duffy antigen systemDuffy antigen system
This species' erythrocytes possess the Duffy antigen and this antigen is used as the receptor for P. vivax on the erythrocytes ... A Duffy negative blood recipient may have a transfusion reaction if the donor is Duffy positive. Since most Duffy-negative ... On erythrocytes, the Duffy antigen acts as a receptor for invasion by the human malarial parasites P. vivax and P. knowlesi. ... Erythrocytes expressing Fya had 41-50% lower binding of P. vivax compared with Fyb cells. Individuals with the Fy(a+b-) ...
https://en.wikipedia.org/wiki/Duffy_antigen_system
KodecyteKodecyte
... created by attaching peptides onto erythrocytes". Transfusion. 50 (3): 635-641. doi:10.1111/j.1537-2995.2009.02480.x. PMID ... "Modeling transfusion reactions with kodecytes and enabling ABO incompatible transfusion with Function-Spacer-Lipid constructs ... Chesla, S; Henry, S; Eatz, R; Sinor, L (2010). "Solid phase syphilis test utilizing KODE technology". Transfusion. 50: 196A- ... Oliver, Caroline; Blake, Debbie; Henry, Stephen (2011). "In vivo neutralization of anti-A and successful transfusion of A ...
https://en.wikipedia.org/wiki/Kodecyte
VenipunctureVenipuncture
... mainly transfusion either in the donor or in another person. Blood analysis is an important diagnostic tool available to ... to remove blood due to excess levels of iron or erythrocytes (red blood cells); or to collect blood for later uses, ...
https://en.wikipedia.org/wiki/Venipuncture
Hemolytic disease of the newbornHemolytic disease of the newborn
Erythrocyte Alloimmunization and Pregnancy at eMedicine Moise Jr KJ (15 March 2018). "Intrauterine fetal transfusion of red ... Once a woman has antibodies, she is at high risk for a future transfusion reaction if she is in need of a blood transfusion. ... Transfusion Reactions at eMedicine "Fatalities Reported to FDA Following Blood Collection and Transfusion: Annual Summary for ... Mid- to late- pregnancy IUT - Intrauterine Transfusion (IUT) is done either by intraperitoneal transfusion (IPT) or intravenous ...
https://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn
Glycophorin CGlycophorin C
This interaction mediates a principal invasion pathway into the erythrocytes. The partial resistance of erythrocytes lacking ... Antibodies to the Gerbich antigens have been associated with transfusion reactions and mild hemolytic disease of the newborn. ... adult liver and erythrocyte. In the non erythroid cell lines, expression is lower than in the erythrocyte and the protein is ... In the erythrocyte glycophorin C makes up ~4% of the membrane sialoglycoproteins. The average number of O linked chains is 12 ...
https://en.wikipedia.org/wiki/Glycophorin_C
Samuel Mitja RapoportSamuel Mitja Rapoport
In World War II there was a great need of transfusions. Many scientists worked on an improvement of the defensibility of the ... His work focused on the water-electrolyte balance and the metabolism of the erythrocytes. He described the role of the 2,3- ... Rapoport detected the eminent importance of the ATP concentration for the survivability of the erythrocytes. ... and chemical changes of erythrocytes in stored blood. Blood preserved in sodium citrate, neutral, and acid citrate-glucose (ACD ...
https://en.wikipedia.org/wiki/Samuel_Mitja_Rapoport
SulfhemoglobinemiaSulfhemoglobinemia
The condition generally resolves itself with erythrocyte (red blood cell) turnover, although blood transfusions can be ...
https://en.wikipedia.org/wiki/Sulfhemoglobinemia
Plasmodium falciparumPlasmodium falciparum
Satchwell, T. J. (2016). "Erythrocyte invasion receptors for Plasmodium falciparum: new and old". Transfusion Medicine. 26 (2 ... The parasite can also alter the morphology of the erythrocyte, causing knobs on the erythrocyte membrane. Infected erythrocytes ... During erythrocyte invasion, merozoites release merozoite cap protein-1 (MCP1), apical membrane antigen 1 (AMA1), erythrocyte- ... to recognize and enter the host erythrocyte (red blood cell). The merozoites first bind to the erythrocyte in a random ...
https://en.wikipedia.org/wiki/Plasmodium_falciparum
Blood bankBlood bank
"Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration". Anesthesia and ... in addition to the very high direct and indirect costs of transfusions, along with the increasing view that many transfusions ... For example, exchange transfusion of RBC in neonates calls for use of blood product that is five days old or less, to "ensure" ... Platelet transfusion is transfused to those with low platelet count. Platelets can be stored at room temperature for up to 5-7 ...
https://en.wikipedia.org/wiki/Blood_bank
ART4ART4
Rios M, Hue-Roye K, Øyen R, Miller J, Reid ME (Jan 2002). "Insights into the Holley- and Joseph- phenotypes". Transfusion. 42 ( ... which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse ... transfusion reactions, are known. Several antigens have been recognised in this family. These are DO*A, DO*JO1, DO*A-WL, DO* ... ". "OBCD Consortium". Reid ME (Jan 2003). "The Dombrock blood group system: a review". Transfusion. 43 (1): 107-14. doi:10.1046 ...
https://en.wikipedia.org/wiki/ART4
Glycated hemoglobinGlycated hemoglobin
Results can be unreliable in many circumstances, for example after blood loss, after surgery, blood transfusions, anemia, or ... high erythrocyte turnover; in the presence of chronic renal or liver disease; after administration of high-dose vitamin C; or ...
https://en.wikipedia.org/wiki/Glycated_hemoglobin
Mycoplasma haemofelisMycoplasma haemofelis
Furthermore, blood transfusion and administration of glucocorticoids relieve the severe anemia resulting from M. haemofelis ... This spontaneous alteration of phenotype seems to allow individuals to detach from erythrocytes by the alteration or ... M. haemofelis has been transmitted by transfusion and oral administration of infected blood. Males show a significant ... Treatment usually includes the administration of doxycycline or enrofloxacin to quell the infection along with transfusion and ...
https://en.wikipedia.org/wiki/Mycoplasma_haemofelis
Fetal-maternal haemorrhageFetal-maternal haemorrhage
Detection of foetal erythrocytes in maternal blood post partum with the fluorescence-activated cell sorter. American Journal of ... Up to 30ml of foetal-maternal transfusion may take place with no significant signs or symptoms seen in either mother or foetus ... If the haemorrhage has already occurred and now stopped, an inutero transfusion of red cells to the foetus may be recommended. ... Fetomaternal Hemorrhage: Incidence, risk factors, time of occurrence, and clinical effects" Transfusion 1990; 30:344-357. ...
https://en.wikipedia.org/wiki/Fetal-maternal_haemorrhage
PorphyriaPorphyria
Blood transfusion is occasionally used to suppress innate heme production.[citation needed] The rarest is congenital ... These are associated with accumulation of porphyrins in erythrocytes and are rare. The pain, burning, swelling, and itching ...
https://en.wikipedia.org/wiki/Porphyria
CD38CD38
The use of Daratumumab can interfere with pre-blood transfusion tests, as CD38 is weakly expressed on the surface of ... This can be sidelined by either pretreatment of the erythrocytes with dithiothreitol (DTT) or by using an anti-CD38 antibody ... erythrocytes. Thus, a screening assay for irregular antibodies against red blood cell antigens or a direct immunoglobulin test ...
https://en.wikipedia.org/wiki/CD38
Erythropoietic protoporphyriaErythropoietic protoporphyria
... parenteral iron and transfusion of erythrocytes are alternative plans for treatment of EEP. Some over-the-counter drugs may ... Since FECH deficiency is associated with increased concentrations of protoporphyrin in erythrocytes, plasma, skin and liver, ... erythrocytes become unstable and injury to the skin is induced. A significant increase in the hepatobiliary excretion of ... erythrocytes), plasma, skin, and liver. The severity varies significantly from individual to individual. A clinically similar ...
https://en.wikipedia.org/wiki/Erythropoietic_protoporphyria
Blood dopingBlood doping
Blood transfusions can be traditionally classified as autologous, where the blood donor and transfusion recipient are the same ... Due to their small size, PFCs are able to permeate circulation where erythrocytes may not flow. In tiny capillaries, PFCs ... Blood transfusion begins by the withdrawal of 1 to 4 units of blood (1 unit = 450 mL of blood) several weeks before competition ... As a significant amount of iron is removed by each autologous transfusion, an adequate time for recovery of not less than 3 ...
https://en.wikipedia.org/wiki/Blood_doping
HemolysisHemolysis
... "lysis of erythrocytes" (erythro- ± cyto- + -lysis). Red blood cells (erythrocytes) have a short lifespan (approximately 120 ... an 18-year study of 865 cases referred to a regional transfusion centre". Br Med J (Clin Res Ed). 282 (6281): 2023-7. doi: ... This breakdown/replacement process is called erythrocyte turnover. In this sense, erythrolysis or hemolysis is a normal process ... "Erythrocyte Alloimmunization and Pregnancy: Overview, Background, Pathophysiology". 2019-02-02. {{cite journal}}: Cite journal ...
https://en.wikipedia.org/wiki/Hemolysis
Tibor J. GreenwaltTibor J. Greenwalt
"History of the International Society of Blood Transfusion". International Society of Blood Transfusion. Archived from the ... Greenwalt, T.J.; Bryan, D.J.; Dumaswala, U.J. (1984). "Erythrocyte membrane vesiculation and changes in membrane composition ... Stansbury, LG; Hess, JR (2010). "Tibor Jack Greenwalt: Father of Transfusion Medicine". Transfusion Medicine Reviews. 24 (4): ... He also developed a filter to remove white blood cells from donor blood to mitigate transfusion reactions (a process known as ...
https://en.wikipedia.org/wiki/Tibor_J._Greenwalt
David DanonDavid Danon
Transfusion. 1963 May-Jun; 3: 161-6. "IAGG Secretariat , Past Presidents". Iagg.info. Archived from the original on 2015-09-24 ... Danon became interested in the process of aging of erythrocytes, and joined the Israeli Association of Gerontology. In 1975 he ... His research during this period continued to focus on erythrocytes and thrombocytes, as well as the interaction between these ... His pearly research in the Institute's Electron Microscopy Laboratory involved the membrane structure of erythrocytes, their ...
https://en.wikipedia.org/wiki/David_Danon
ApheresisApheresis
Erythrocytapheresis - removal of erythrocytes (red blood cells) in people with iron overload as a result of Hereditary ... Transfusion Today, 2007, 71:7-9. Koch, Holger M.; Bolt, Hermann M.; Preuss, Ralf; Eckstein, Reinhold; Weisbach, Volker; Angerer ... The automated red blood cell collection procedure for donating erythrocytes is referred to as 'Double Reds' or 'Double Red Cell ... There is limited data to suggest the benefit of granulocyte transfusion. The complications of this procedure are the difficulty ...
https://en.wikipedia.org/wiki/Apheresis
Tumors of the hematopoietic and lymphoid tissuesTumors of the hematopoietic and lymphoid tissues
The myeloid cell line normally produces granulocytes, erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell ... blood transfusions in MDS). The more aggressive forms of disease require treatment with chemotherapy, radiotherapy, ...
https://en.wikipedia.org/wiki/Tumors_of_the_hematopoietic_and_lymphoid_tissues
Scott syndromeScott syndrome
... erythrocytes contain a membrane protein capable of mediating Ca2+-dependent transbilayer migration of membrane ... the only treatment for episodes of bleeding is the transfusion of normal platelets.[citation needed] Weiss HJ. Scott syndrome: ... Defective Ca2+ induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with ...
https://en.wikipedia.org/wiki/Scott_syndrome
Blood testBlood test
Erythrocyte sedimentation rate (ESR) Cross-matching. Determination of blood type for blood transfusion or transplants Blood ...
https://en.wikipedia.org/wiki/Blood_test
Malaria prophylaxisMalaria prophylaxis
Erythrocyte-binding-like proteins (EBLs) and reticulocyte-binding protein homologues (RHs) are both used by specialized P. ... Further additions to preventive care are sanctions on blood transfusions. Once the malaria parasite enters the erythrocytic ... Gao X, Gunalan K, Yap SS, Preiser PR (2013). "Triggers of key calcium signals during erythrocyte invasion by Plasmodium ...
https://en.wikipedia.org/wiki/Malaria_prophylaxis
Immunoglobulin MImmunoglobulin M
... together with erythrocytes, a much stronger antibody response to the erythrocytes is induced than when erythrocytes are ... of red blood cells if the recipient of a blood transfusion receives blood that is not compatible with their blood type. A ... This effect is used clinically to prevent Rh-negative mothers from becoming immunized against fetal Rh-positive erythrocytes, ... Such effects are well illustrated by experiments involving immunization with xenogenic (foreign) erythrocytes (red cells). For ...
https://en.wikipedia.org/wiki/Immunoglobulin_M
PancytopeniaPancytopenia
To tide over immediate crisis Blood transfusion with packed red blood cells (PRBC) or platelet transfusion may be done. ... The T cell activated macrophages engulf erythrocytes, leukocytes, platelets, as well as their progenitor cells. Along with ... In this selected cases even with severe anemia blood product transfusions can be avoided and vitamin B12 treatment itself ...
https://en.wikipedia.org/wiki/Pancytopenia
BabesiosisBabesiosis
Leiby DA (2011). "Transfusion-associated babesiosis: shouldn't we be ticked off?". Ann Intern Med. 155 (8): 556-7. doi:10.7326/ ... Diagnosis is confirmed post mortem by observation of Babesia-infected erythrocytes sludged in the cerebral cortical capillaries ... People can get infected with Babesia parasites by the bite of an infected tick, by getting a blood transfusion from an infected ... People with symptoms usually become ill 1 to 4 weeks after the bite, or 1 to 9 weeks after transfusion of contaminated blood ...
https://en.wikipedia.org/wiki/Babesiosis
JaundiceJaundice
... erythrocyte) hemolysis. The increased breakdown of erythrocytes → increased unconjugated serum bilirubin → increased deposition ... Jaundice in newborns may be treated with phototherapy or exchanged transfusion depending on age and prematurity when the ... These diseases may cause jaundice due to increased erythrocyte hemolysis: Sickle-cell anemia Spherocytosis Thalassemia Pyruvate ... infant may be treated with phototherapy or exchanged transfusion depending on the infant's age and prematurity status. A bili ...
https://en.wikipedia.org/wiki/Jaundice
Beta oxidationBeta oxidation
Stier A, Bize P, Schull Q, Zoll J, Singh F, Geny B, Gros F, Royer C, Massemin S, Criscuolo F (June 2013). "Avian erythrocytes ... Yoshida T, Shevkoplyas SS (October 2010). "Anaerobic storage of red blood cells". Blood Transfusion = Trasfusione del Sangue. 8 ... The enzyme catalase, found primarily in peroxisomes and the cytosol of erythrocytes (and sometimes in mitochondria), converts ...
https://en.wikipedia.org/wiki/Beta_oxidation
Urine test stripUrine test strip
An improper technique can produce false results, for example, leukocytes and erythrocytes precipitate at the bottom of the ... Hemoglobinuria can be caused by hemolytic anaemia, blood transfusions, extensive burns, the bite of the recluse spider ( ...
https://en.wikipedia.org/wiki/Urine_test_strip
Aquaporin-3Aquaporin-3
2009). "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte". Mol. Biochem ... Transfusion. 48 (6): 1164-8. doi:10.1111/j.1537-2995.2008.01683.x. PMID 18435676. S2CID 5795042. Wang S, Amidi F, Beall M, et ...
https://en.wikipedia.org/wiki/Aquaporin-3
List of MeSH codes (E02)List of MeSH codes (E02)
... erythrocyte transfusion MeSH E02.095.135.140.425 - leukocyte transfusion MeSH E02.095.135.140.425.445 - lymphocyte transfusion ... blood transfusion, intrauterine MeSH E02.095.135.469 - exchange transfusion, whole blood MeSH E02.095.135.750 - plasma exchange ... MeSH E02.095.135.140 - blood component transfusion MeSH E02.095.135.140.275 - ... MeSH E02.095.135.140.650 - platelet transfusion MeSH E02.095.135.164 - blood transfusion, autologous MeSH E02.095.135.264 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(E02)
HemolysinHemolysin
One way hemolysin lyses erythrocytes is by forming pores in phospholipid bilayers. Other hemolysins lyse erythrocytes by ... a blood transfusion. In rare cases, the spleen must be removed because it filters blood and removes dead or damaged cells from ... Upon investigating sheep erythrocytes, its toxic mechanism was discovered to be the hydrolysis of a specific membrane lipid, ... As the bone marrow cannot make erythrocytes fast enough to meet the body's needs, oxygen does not arrive to body tissues ...
https://en.wikipedia.org/wiki/Hemolysin
Sickle cell nephropathySickle cell nephropathy
Even in ESRD when those with SCD become transfusion dependent, ESAs can still be used to increase the interval between ... combined with ischemic tubule injury and sickled erythrocytes in the vasa recta of the inner medulla impairing free water ... IV iron therapy is recommended if not receiving the necessary iron from blood transfusions but the dosing is unclear. Diuretics ... If exhibiting hematuria, a CT scan should be done to exclude medullary carcinoma and due to multiple blood transfusions, ...
https://en.wikipedia.org/wiki/Sickle_cell_nephropathy
Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings - Kölner...Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings - Kölner...
Background: Group O erythrocytes and/or whole blood are used for urgent transfusions in patients of unknown blood type. This ... Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings. Anesthesiology ... Conclusions: The transfusion of smaller quantities of uncrossmatched type O erythrocyte-containing products, in particular up ... Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings ...
https://kups.ub.uni-koeln.de/34212/
EXPANDED ANTIGEN-MATCHING FOR ERYTHROCYTE TRANSFUSION OF WOMEN WITH SICKLE CELL DISEASE DURING PREGNANCY REDUCES TRANSFUSION...EXPANDED ANTIGEN-MATCHING FOR ERYTHROCYTE TRANSFUSION OF WOMEN WITH SICKLE CELL DISEASE DURING PREGNANCY REDUCES TRANSFUSION...
EXPANDED ANTIGEN-MATCHING FOR ERYTHROCYTE TRANSFUSION OF WOMEN WITH SICKLE CELL DISEASE DURING PREGNANCY REDUCES TRANSFUSION- ... EXPANDED ANTIGEN-MATCHING FOR ERYTHROCYTE TRANSFUSION OF WOMEN WITH SICKLE CELL DISEASE DURING PREGNANCY REDUCES TRANSFUSION- ... Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings Anesthesiology ( ...
https://pubs.asahq.org/anesthesiology/article/96/4/NA/42855/EXPANDED-ANTIGEN-MATCHING-FOR-ERYTHROCYTE
Erythrocyte ageing in vivo and in vitro: structural aspects and implications for transfusion.Erythrocyte ageing in vivo and in vitro: structural aspects and implications for transfusion.
Fresh frozen plasma for cardiovascular surgeryFresh frozen plasma for cardiovascular surgery
Transfusion with FFP was inferior to control for preventing patients receiving any red cell transfusion: Peto odds ratio (OR) ... Objectives: To evaluate the risk to benefit ratio of FFP transfusion in cardiovascular surgery for the treatment of bleeding ... There were no reported adverse events attributable to FFP transfusion, although there was a significant increase in the number ... Overall the evidence from randomised controlled trials for the safety and efficacy of prophylactic transfusion of FFP for ...
https://pubmed.ncbi.nlm.nih.gov/26171897/
Table 3 - Epidemiology of Hospitalized Patients with Babesiosis, United States, 2010-2016 - Volume 28, Number 2-February 2022 -...
Erythrocyte transfusion. 1560 (20.0). 1375 (21.6). 185 (12.8). Platelet transfusion. 208 (2.7). 183 (2.9). 25 (1.7). ...
https://wwwnc.cdc.gov/eid/article/28/2/21-0213-t3
When is a transfusion of blood components indicated - Banc de Sang i TeixitsWhen is a transfusion of blood components indicated - Banc de Sang i Teixits
When are transfusions of erythrocyte concentrates given?. Erythrocyte concentrates are transfused to correct the symptoms and ... When is a transfusion of blood components indicated Blood transfusions are indicated for the treatment of patients who, at any ... A platelet transfusion can cause the following side effects (which are more common than with other transfusions):. febrile ... The risks associated with plasma transfusions include: circulatory overload, destruction of erythrocytes resulting from ABO ...
https://www.bancsang.net/pacients/banc-sang/en_index/
EXTEND EXpanding Treatment for Existing Neurological Disease - Full Text View - ClinicalTrials.govEXTEND EXpanding Treatment for Existing Neurological Disease - Full Text View - ClinicalTrials.gov
Erythrocyte transfusion within the past 2 months. *Previous stem cell transplant or other myelosuppressive therapy (unless they ... Use of therapeutic agents for sickle cell disease (e.g., hydroxyurea, arginine, decitabine, magnesium, chronic transfusions) ...
https://clinicaltrials.gov/ct2/show/NCT02556099
Erythrocyte Aging | Harvard Catalyst Profiles | Harvard CatalystErythrocyte Aging | Harvard Catalyst Profiles | Harvard Catalyst
Blood transfusion promotes cancer progression: a critical role for aged erythrocytes. Anesthesiology. 2008 Dec; 109(6):989-97. ... "Erythrocyte Aging" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Erythrocyte Aging" by people in Harvard Catalyst Profiles by ... C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex. J Clin Invest. 2009 ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Erythrocyte%20Aging
Erythrocyte Morphology on Peripheral SmearErythrocyte Morphology on Peripheral Smear
... , Erythrocyte Morphology, Red Blood Cell Morphology, Macrocyte, Microcyte, Spherocyte ... Hemolytic Transfusion Reactions. *Severe Hypophosphatemia. *Acute Oxidant Injury: Hexose Monophosphate Shunt Defect ... Erythrocyte Morphology on Peripheral Smear. Erythrocyte Morphology on Peripheral Smear Aka: Erythrocyte Morphology on ... Erythrocyte Morphology on Peripheral Smear Erythrocyte Protoporphyrin Erythrocyte Sedimentation Rate Fibrin Degradation ...
https://fpnotebook.com/hemeonc/Lab/ErythrcytMrphlgyOnPrphrlSmr.htm
Babesiosis Treatment & Management: Approach Considerations, Pharmacologic Therapy, Exchange Transfusion and Supportive CareBabesiosis Treatment & Management: Approach Considerations, Pharmacologic Therapy, Exchange Transfusion and Supportive Care
... exchange transfusion reduces the level of parasitemia and may remove toxic erythrocyte, babesial, or macrophage-produced ... Exchange Transfusion and Supportive Care. Exchange transfusion is employed in patients who are profoundly ill with high levels ... Transfusion-transmitted babesiosis: a case report from a new endemic area. Transfusion. 1991 May. 31(4):365-8. [QxMD MEDLINE ... Treatment of transfusion-transmitted babesiosis by exchange transfusion. N Engl J Med. 1980 Nov 6. 303(19):1098-100. [QxMD ...
https://emedicine.medscape.com/article/212605-treatment
Postpartum Complications FlashcardsPostpartum Complications Flashcards
Need for erythrocyte transfusion. *Occurs in 18% of women. Term. Early, Acute, or Primary PPH. ...
https://www.flashcardmachine.com/postpartum-complications1.html
Epidemiologic Notes and Reports Update: Yersinia enterocolitica Bacteremia and Endotoxin Shock Associated with Red Blood Cell...Epidemiologic Notes and Reports Update: Yersinia enterocolitica Bacteremia and Endotoxin Shock Associated with Red Blood Cell...
Sepsis associated with transfusion of red cells contaminated with Yersinia enterocolitica. Transfusion 1990;30:207-13. ... Growth and endotoxin production of Yersinia enterocolitica and Enterobacter agglomerans in packed erythrocytes. J Clin ... Infectious complications due to transfusion acquired Yersinia enterocolitica. Transfusion 1989;29:372-3. ... The RBC units had been stored at 39.2 F (4 C) for a mean of 33 days (range: 25- 42 days) before transfusion. One of the units ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/00001932.htm
Blood bank storage of red blood cells increases RBC cytoplasmic membrane order and bending rigidity | PLOS ONEBlood bank storage of red blood cells increases RBC cytoplasmic membrane order and bending rigidity | PLOS ONE
Blood banks around the world store blood components for several weeks ensuring its availability for transfusion medicine. Red ... La Celle P (1969) Alteration of deformability of the erythrocyte membrane in stored blood. Transfusion 9(5):238-245. pmid: ... structural aspects and implications for transfusion. Transfusion Medicine 18(6):335-347. pmid:19140816 * View Article ... 6. Wang D, Sun J, Solomon SB, Klein HG, Natanson C (2012) Transfusion of older stored blood and risk of death: a meta-analysis ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0259267
Anemia: Practice Essentials, Pathophysiology, EtiologyAnemia: Practice Essentials, Pathophysiology, Etiology
Methods for measuring RBC mass are time consuming and expensive and usually require transfusion of radiolabeled erythrocytes. ... educate patients who require periodic transfusions about the symptoms that herald the need for transfusion. Likewise, they ... Erythrocytes are highly deformable and increase their diameter from 7 µm to 13 µm when they traverse capillaries with a 3-µm ... Because erythrocytes have no nucleus, they lack a Krebs cycle and rely on glycolysis via the Embden-Meyerhof and pentose ...
https://www.medscape.com/answers/198475-155019/what-is-the-life-cycle-of-erythrocytes
Upper Gastrointestinal Bleeding (UGIB) Guidelines: Perforated and Bleeding Peptic Ulcer Clinical Practice Guidelines (2020),...Upper Gastrointestinal Bleeding (UGIB) Guidelines: Perforated and Bleeding Peptic Ulcer Clinical Practice Guidelines (2020),...
Table 3. Effect of Number of Packed Erythrocyte Transfusions on Need for Surgery and Mortality from UGIB ... Table 3. Effect of Number of Packed Erythrocyte Transfusions on Need for Surgery and Mortality from UGIB ... Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with ... Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med. 2013 Jan 3. 368(1):11-21. [QxMD MEDLINE Link]. ...
https://emedicine.medscape.com/article/187857-guidelines
Neurology - Research output - Mayo Clinic
Investigation of acoustic whole blood plasmapheresis for minimization of endogenous blood loss in neonatal care | LUP Student...Investigation of acoustic whole blood plasmapheresis for minimization of endogenous blood loss in neonatal care | LUP Student...
Early erythrocyte transfusion is common in infants born extremely premature. Research has shown that these children are at ... Early erythrocyte transfusion is common in infants born extremely premature. Research has shown that these children are at ... misc{9066938, abstract = {{Early erythrocyte transfusion is common in infants born extremely premature. Research has shown that ... and that iatrogenic blood loss from blood sample analysis is one of the contributing factors to the need for transfusions.. ...
https://lup.lub.lu.se/student-papers/search/publication/9066938
Pathology Outlines - Plasmodium malariae
P. vivax and P. ovale parasites primarily infect young erythrocytes, whereas P. malariae infects older erythrocytes and P. ... Liver cells are infected only by sporozoites from the mosquito; thus, transfusion acquired P. vivax or P. ovale infection does ... Transfusion induced malaria may occur when blood donors have subclinical malaria and may prove fatal for the recipient * ... Neither transfusion nor congenital malaria is expected to relapse because exoerythrocytic schizogony does not occur ...
https://www.pathologyoutlines.com/topic/parasitologypmalariae.html
Prehospital plasma is associated with survival principally in patients transferred from the scene of injury: A secondary...
... erythrocyte ratios in trauma requiring massive transfusion. ... Massive transfusion and the response to prehospital plasma: it ... Prehospital blood product transfusion and combat injury survival-reply.. JAMA. 2018; 319: 1167-1168. View in Article *Scopus (2 ... Pre-hospital transfusion of plasma in hemorrhaging trauma patients independently improves hemostatic competence and acidosis. ... Association of prehospital plasma transfusion with survival in trauma patients with hemorrhagic shock when transport times are ...
https://www.surgjournal.com/article/S0039-6060
Variant Creutzfeldt-Jakob Disease Death, United States - Volume 11, Number 9-September 2005 - Emerging Infectious Diseases...
Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient. Lancet. 2004;364:527-9. DOIPubMedGoogle ... One of the 2 recipients was 62 years of age and had received 5 units of erythrocytes in 1996 (5). One of these units was traced ... In 2002 (6.5 years after the transfusion), vCJD developed in the recipient, who died 13 months after illness onset. An autopsy ... Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Lancet. 2004;363:417-21. DOIPubMedGoogle ...
https://wwwnc.cdc.gov/eid/article/11/9/05-0371_article
A GIANT BENIGN POLYP OF THE STOMACH | Article | NursingCenterA GIANT BENIGN POLYP OF THE STOMACH | Article | NursingCenter
She denied melena or hematemesis, but she had been given 3 units of erythrocyte transfusion 2 months before in another health ...
https://www.nursingcenter.com/journalarticle?Article_ID=3913030&Journal_ID=54035&Issue_ID=3912685
MKSAP Quiz: 5-day history of asymptomatic rash | ACP InternistMKSAP Quiz: 5-day history of asymptomatic rash | ACP Internist
He has a myelodysplastic syndrome and has received intermittent erythrocyte transfusions, and he takes azacitidine. Following a ... He has a myelodysplastic syndrome and has received intermittent erythrocyte transfusions, and he takes azacitidine. ...
https://acpinternist.org/archives/2014/11/mksap.htm
Home care for children following haematopoietic stem cell transplantation<...
Platelet Transfusion Medicine & Life Sciences 23% * Erythrocyte Transfusion Medicine & Life Sciences 23% ... Overall activity consisted of 1232 i.v. therapies, 501 blood tests, 58 red blood cell or platelet transfusions, 107 procedures ... Overall activity consisted of 1232 i.v. therapies, 501 blood tests, 58 red blood cell or platelet transfusions, 107 procedures ... Overall activity consisted of 1232 i.v. therapies, 501 blood tests, 58 red blood cell or platelet transfusions, 107 procedures ...
https://moh-it.pure.elsevier.com/en/publications/home-care-for-children-following-haematopoietic-stem-cell-transpl
Feline Anemias-Therapeutic Options and Transfusion Therapy - WSAVA2002 - VINFeline Anemias-Therapeutic Options and Transfusion Therapy - WSAVA2002 - VIN
Thus, only homozygous B/B cats express the type B antigen on their erythrocytes. Type A cats are either homozygous (A/A) or ... A mismatched transfusion with type A blood given to a type B cat will result in a very serious acute hemolytic transfusion ... Thus, mismatched transfusions are dangerous as well as ineffective. Hemolytic transfusion reactions are difficult to manage and ... Transfusion therapy has taken an increasingly important role in the life support of cats. Over the past decade the use of blood ...
https://www.vin.com/apputil/content/defaultadv1.aspx?pId=11147&catId=29496&id=3846212&ind=97&objTypeID=17
Famine-Affected, Refugee, and Displaced PopulationsFamine-Affected, Refugee, and Displaced Populations
For some patients (especially children), blood transfusion may be lifesaving. Recent studies indicate that blood transfusion ... Folic acid replacement may be helpful during the recovery period when rapid erythrocyte replacement occurs. Renal failure. ... Blood transfusion is indicated when Hb less than 4 g/dL, or Hb less than 6 g/dL is detected and the patient has signs of heart ... Because of the potential for HIV or hepatitis B transmission, blood transfusion should be reserved for medical emergencies for ...
https://wonder.cdc.gov/wonder/prevguid/p0000113/p0000113.asp
Unrelated HSCT in an adolescent affected by congenital erythropoietic porphyria | Semantic ScholarUnrelated HSCT in an adolescent affected by congenital erythropoietic porphyria | Semantic Scholar
Attempts to reduce erythropoiesis and to lower circulating porphyrin levels by means of erythrocyte transfusions have been ... However, the complications of a chronic transfusion regimen are potentially severe. Successful bone marrow transplantation has ... and attempts to reduce erythropoiesis and to lower circulating porphyrin levels by means of erythrocyte transfusions have been ... Attempts to reduce erythropoiesis and to lower circulating porphyrin levels by means of erythrocyte transfusions have been ...
https://www.semanticscholar.org/paper/Unrelated-HSCT-in-an-adolescent-affected-by-Faraci-Morreale/94233e72eb47727b717f336ccf752b172752c9f1
Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study<...
Erythrocytes Medicine & Life Sciences 90% * Wounds and Injuries Medicine & Life Sciences 55% ... Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study. ... Transfusion of RBC/FFP ≥1.5:1 or RBC/PLT ≥1.5:1 was significantly associated with mortality, most pronounced for the 18% of ... Transfusion of RBC/FFP ≥1.5:1 or RBC/PLT ≥1.5:1 was significantly associated with mortality, most pronounced for the 18% of ...
https://pennstate.pure.elsevier.com/en/publications/outcomes-after-ultramassive-transfusion-in-the-modern-era-an-east
Hemolytic Transfusion ReactionReceive blood transfusionsPlateletAcuteHemorrhageExchange TransfusionReactionSicklePatientsHematologyAnemiaAutologousReactionsChronicApheresisBlood cellOutcomesAbstract2020ThalassemiaClinicalFetalMyelodysplastic syndromeRBCsComplicationIncompatible bloodDonorsMedicineAntigensObjectiveOccursPracticeSurvivalProgressionConcentrates2018AntigenPertinentTherapyInfantsConclusionsDonorProteinsMembraneStudy aimedMethodsPatientTreatmentImplications
Hemolytic Transfusion Reaction2
  • A mismatched transfusion with type A blood given to a type B cat will result in a very serious acute hemolytic transfusion reaction. (vin.com)
  • Acute transfusion reactions can manifest in many forms including acute hemolytic transfusion reaction, allergic reaction and transfusion-related. (realtalifesciences.com)
Receive blood transfusions1
  • This will ensure that people with sickle cell disease receive blood transfusions that work best for them. (nih.gov)
Platelet4
  • Transfusions of platelet concentrates are usually given to prevent haemorrhage in patients who present with low levels of platelets in their blood or where there is something wrong with their platelets . (bancsang.net)
  • A reduction in the platelet count is not, in itself, a reason to carry out a transfusion of platelet concentrates. (bancsang.net)
  • In order for the post-transfusion platelet count to increase by about 20,000 / ?l, the appropriate dose for an adult is 3x1011 platelets, in other words, 300 billion platelets. (bancsang.net)
  • Overall activity consisted of 1232 i.v. therapies, 501 blood tests, 58 red blood cell or platelet transfusions, 107 procedures on Central Venous Catheter. (elsevier.com)
Acute3
  • These anti-A antibodies are responsible for the life-threatening incompatibility reactions such as neonatal isoerythrolysis and acute hemolytic transfusion reactions. (vin.com)
  • Incompatible Erythrocyte Transfusion With Lipopolysaccharide Induces Acute Lung Injury. (realtalifesciences.com)
  • b) Blood transfusion which may control EBOV-induced acute DIC, an excessive immune response. (biomedcentral.com)
Hemorrhage1
  • BACKGROUND Despite the widespread institution of modern massive transfusion protocols with balanced blood product ratios, survival for patients with traumatic hemorrhage receiving ultramassive transfusion (UMT) (defined as ≥20 U of packed red blood cells [RBCs]) in 24 hours) remains low and resource consumption remains high. (elsevier.com)
Exchange Transfusion1
  • To participate in this study, you must be at least 18 years old, have sickle cell disease, and have not been on a chronic exchange transfusion program for at least 2 months. (nih.gov)
Reaction2
  • Editorial Note: Bacteremia is a rare complication of blood transfusion, but it should be considered whenever a severe unexplained transfusion reaction occurs--particularly when fever and hypotension occur. (cdc.gov)
  • A first transfusion and as little as one milliliter of incompatible blood may cause a fatal reaction without prior sensitization. (vin.com)
Sickle6
  • Are you an adult who receives long-term red blood cell transfusion therapy for sickle cell disease? (nih.gov)
  • This research aims to inform new evidence-based policies on the age and use of donor blood in people with sickle cell disease that rely on blood transfusions. (nih.gov)
  • To participate in this study, you must be between 16 and 45 years old, have sickle cell disease, and be receiving long-term red blood cell transfusion therapy. (nih.gov)
  • Are you an adult who receives regular blood transfusions every 4 to 8 weeks for sickle cell disease? (nih.gov)
  • Iron overload due to multiple transfusions for chronic anemia (eg, thalassemia or sickle cell disorder) can be treated with chelation therapy. (medscape.com)
  • Erythrocytes in sickle form, cellular expression of polymerization of deoxygenated HbS, cause intermittent vascular obstruction, leading to tissue ischaemia and consequent chronic damage in organs and endocrine glands. (bvsalud.org)
Patients20
  • Background: Group O erythrocytes and/or whole blood are used for urgent transfusions in patients of unknown blood type. (uni-koeln.de)
  • Among patients who received up to 10 uncrossmatched type O erythrocyte-containing products, the median A antigen agglutination strength in A and AB individuals on forward typing (i.e., testing the recipient's erythrocytes for A and/or B antigens) was the maximum (4+), whereas the median B antigen agglutination strength among B and AB recipients of up to 10 units was 3 to 4+. (uni-koeln.de)
  • 95% CI, 93.9 to 97.0%) of these patients could be accurately determined on the first type and screen sample obtained after transfusion of uncrossmatched type O erythrocyte-containing products. (uni-koeln.de)
  • To evaluate the risk to benefit ratio of FFP transfusion in cardiovascular surgery for the treatment of bleeding patients or for prophylaxis against bleeding. (nih.gov)
  • There were no reported adverse events attributable to FFP transfusion, although there was a significant increase in the number of patients requiring red cell transfusion who were randomised to FFP. (nih.gov)
  • Home Patients Blood Bank When is a transfusion of blood components indicated? (bancsang.net)
  • In patients with fever of unknown origin (FUO), consider babesiosis as a diagnosis if the patient lives in an endemic area, has traveled to an endemic area, or received a blood transfusion in the past. (medscape.com)
  • this could include vasopressors for hypotensive patients, blood transfusions, and dialysis. (medscape.com)
  • Each of the six patients developed fever and hypotension within 50 minutes after the start of transfusion. (cdc.gov)
  • From April 1987 through February 1991, seven deaths occurred among the 10 reported patients with RBC transfusion-associated Y. enterocolitica in the United States. (cdc.gov)
  • Blod innehåller information i form av olika biomarkörer som läkare och vårdpersonal behöver för att ställa diagnos eller övervaka en patients hälsa. (lu.se)
  • CONCLUSION Despite modern massive transfusion protocols, one half of trauma patients receiving UMT are transfused with either RBC/FFP or RBC/PLT in unbalanced ratios ≥1.5:1, with increased associated mortality. (elsevier.com)
  • The objective of this study was to determine whether the CPG was associated with a change in the transfusion practices in combat-wounded patients. (uthscsa.edu)
  • The aim of the present study was to identify these modifications on blood samples stored in transfusion bags, at different storage time points.METHODS: Twenty-three hemochromatosis patients undergoing periodic phlebotomy sessions for therapeutic purposes at the San Luigi Gonzaga Hospital in Orbassano, Turin, were enrolled in the study. (unito.it)
  • Storage of blood of these patients leads to significantly increased K+ levels, with serious clinical implications for neonates and infants receiving large-volume transfusions of whole blood. (unina.it)
  • However, transfusions may be essential for patients with angina or a severely compromised cardiopulmonary status. (medscape.com)
  • A survey performed by an expert advisory board gathered information on the amounts reimbursed by health plans to blood centers per outpatient transfusion of a single RBC bag in multitransfused patients. (bvsalud.org)
  • we need blood grouping in cases of transfusion to avoid incompatibility, which often leads to blood clumping and agglutination then eventually death of patients, not only that but they are also important in pregnancies in cases of maternal fetal incompatibility. (cram.com)
  • Abnormal bleeding, as well as erythrocyte macrocytosis, is reported and patients usually become transfusion-dependent. (cdc.gov)
  • Le protocole utilisé dans le traitement du myélome multiple a été le VMCD-REV à 76,92% avec pour réponse thérapeutique complète chez 6 patients, 3 réponses partielles et 4 en cours de traitement. (bvsalud.org)
Hematology1
  • Medicoinfo cover several fields of General Medicine and Diagnostic Pathology including Hematology, Biochemistry, Microbiology Pathology Transfusion Medicine etc. (medicoinfo.org)
Anemia3
  • The usual neutrophil count ranged from 2 to 4×109/L. With the progression of anemia, more erythrocyte transfusions were gradually required.Blood cultures and specimens taken from cutaneous punctures yielded Pseudomonas aeruginosa. (deepdyve.com)
  • Hemolytic anemia in PNH results from the increased susceptibility of PNH erythrocytes to complement. (diseasesdic.com)
  • If the anemia is severe or rapidly progressive, however, supportive care with transfusions of packed red blood cells may be warranted. (medscape.com)
Autologous1
  • BACKGROUND: There is currently no direct method to detect the use of autologous blood transfusions in the context of anti-doping controls. (unito.it)
Reactions1
  • Hemolytic transfusion reactions are difficult to manage and no specific protocol has proven effective. (vin.com)
Chronic2
  • Therefore, the present study aimed to estimate the cost of chronic red blood cell (RBC) transfusion in this context. (bvsalud.org)
  • Chronic red blood cell transfusion cost was estimated in Brazil using reimbursement information from private health plans and Brazilian Hierarchical Classification of Medical Procedures parameters. (bvsalud.org)
Apheresis1
  • Transfusion and apheresis use, no. (cdc.gov)
Blood cell4
  • From April 1987 through August 1988, four cases of Yersinia enterocolitica bacteremia associated with red blood cell (RBC) transfusions were reported to CDC (1,2). (cdc.gov)
  • In addition, red blood cell (RBC) transfusion requirement at diagnosis (P = 0.001), but not the number of RBC units transfused during the disease course (P = 0.17), was independently associated with inferior survival. (elsevier.com)
  • In March 2006, the US Army issued a damage control resuscitation CPG, encouraging 1:1 plasma:red blood cell (RBC) transfusions and limiting crystalloid use. (uthscsa.edu)
  • Genetic defects of erythrocyte transport proteins cause disorders of red blood cell volume that are characterized by abnormal permeability to the cation and, consequently, by changes in red cell hydration. (unina.it)
Outcomes1
  • Erythropoietin (EPO) has been used to try to reduce transfusion requirements, with variable outcomes. (medscape.com)
Abstract1
  • ENGLISH ABSTRACT: Sub-Saharan Africa (SSA) has a unique set of challenges pertaining to blood transfusion. (sun.ac.za)
20201
  • Il s'agissait d'une étude rétrospective descriptive d'une durée de 2 ans 3 mois allant du 1er janvier 2018 au 31 Mars 2020 portant sur 80 dossiers de malades porteurs d'hémopathies malignes et prise en charge dans le centre. (bvsalud.org)
Thalassemia1
  • RANK/RANKL/OPG axis genes relation to cognitive impairment in children with transfusion-dependent thalassemia: a cross-sectional study. (cdc.gov)
Clinical2
  • However, bearing in mind that blood components are human products and, therefore, have their risks, each transfusion has to be treated as a clinical decision that must be based on the condition of the patient, on analytical data and on a positive risk/benefit evaluation. (bancsang.net)
  • Blood transfusion is a treatment that must adapt to clinical and biological status of each patient. (medical-actu.com)
Fetal2
  • Bilirubin production is elevated because of increased breakdown of fetal erythrocytes. (medscape.com)
  • This is the result of the shortened lifespan of fetal erythrocytes and the higher erythrocyte mass in neonates. (medscape.com)
Myelodysplastic syndrome1
  • He has a myelodysplastic syndrome and has received intermittent erythrocyte transfusions, and he takes azacitidine. (acpinternist.org)
RBCs2
  • From April 1987 through February 1991, Y. enterocolitica was responsible for seven of the eight total transfusion-associated fatalities linked to bacterial contamination of RBCs that had been reported to the Food and Drug Administration (FDA) (FDA, unpublished data). (cdc.gov)
  • This WBC was surrounded by numbers of normal red blood cells (RBCs), also referred to as erythrocytes. (cdc.gov)
Complication2
  • Blood loss, transfusion and complication rates were evaluated until three months after surgery. (biomedcentral.com)
  • The intraarticular application of 2 g TXA resulted in a significant reduction of blood loss and transfusion rate after primary TKA without increased complication rates. (biomedcentral.com)
Incompatible blood1
  • One should use the least incompatible blood if transfusions are indicated. (medscape.com)
Donors1
  • Furthermore, the need for blood typing and cross matching as well as testing of donors for transmittable diseases has now been recognized in order to assure safe and more efficacious transfusions. (vin.com)
Medicine4
  • Blood banks around the world store blood components for several weeks ensuring its availability for transfusion medicine. (plos.org)
  • The long term storage of blood components is essential in transfusion medicine. (plos.org)
  • Mochizuki, T, Tauxe, WN & Ramsey, G 1990, ' In vivo cross-match by chromium-51 urinary excretion from labeled erythrocytes: A case of anti-Gerbich ', Journal of Nuclear Medicine , vol. 31, no. 12, pp. 2042-2045. (northwestern.edu)
  • Division of Transfusion Medicine, University of Cambridge, UK. (openrepository.com)
Antigens1
  • Next to that antigen D, we must emphasize the importance (in transfusion and obstetrics) antigens C, c, E, e, which are among the most immunizing antigens. (medical-actu.com)
Objective1
  • why it is necessary , the objective of the transfusion, triggering mechanism corrective measures , possible therapeutic alternatives and their efficacy , as well as possible side effects which the transfusion may cause. (bancsang.net)
Occurs1
  • Binding to other proteins and erythrocytes also occurs, but the physiologic role is probably limited. (medscape.com)
Practice2
  • Contemporary transfusion practice : based on the Contemporary Transfusion Practice Technical Workshop, held in Orlando, Fla. in 1987 / editors, Jerry Kolins, Leo J. McCarthy. (who.int)
  • Contemporary Transfusion Practice Technical Workshop (1987 : Orlando, Fla. (who.int)
Survival1
  • Among the many possible contributing factors to improved survival is the availability of large-volume transfusion support and improved understanding of trauma-related defects in hemostasis. (biomedcentral.com)
Progression1
  • Blood transfusion promotes cancer progression: a critical role for aged erythrocytes. (harvard.edu)
Concentrates3
  • When are transfusions of erythrocyte concentrates given? (bancsang.net)
  • Erythrocyte concentrates are transfused to correct the symptoms and signs of a lack of oxygen in tissues that are found in anaemia produced by different causes. (bancsang.net)
  • Due to the lower cost of TXA compared to applied erythrocyte concentrates a side effect of the treatment was a cost reduction of € 1.609 within this cohort. (biomedcentral.com)
20181
  • Analyses using 2018 CBHPM parameters may lead to overestimation of transfusion cost. (bvsalud.org)
Antigen2
  • Thus, only homozygous B/B cats express the type B antigen on their erythrocytes. (vin.com)
  • The causative gene of this condition is ABCB6, encoding an erythrocyte membrane ABC transporter protein bearing the Langereis blood group antigen system. (unina.it)
Pertinent1
  • In June 2011 the Canadian National Advisory Committee on Blood and Blood Products sponsored a 3-day consensus conference, during which a field of international leaders presented data focused on six specific questions pertinent to trauma and transfusion support. (biomedcentral.com)
Therapy2
  • Transfusion therapy has taken an increasingly important role in the life support of cats. (vin.com)
  • EPO therapy costs more than transfusions. (medscape.com)
Infants1
  • Early erythrocyte transfusion is common in infants born extremely premature. (lu.se)
Conclusions2
  • Conclusions: The transfusion of smaller quantities of uncrossmatched type O erythrocyte-containing products, in particular up to 10 units, does not usually interfere with determining the recipient's ABO type. (uni-koeln.de)
  • The analysis of band 3 showed a gradual fragmentation of the protein during storage time.CONCLUSIONS: The results of the present study confirmed the observations of scientific literature demonstrating a modification of erythrocyte proteins during red blood cells (RBC) storage. (unito.it)
Donor2
  • This cross-match test was based on the determination of the urinary excretion rates of injected radioactive chromium-labeled donor erythrocytes by which it was possible to determine compatibility only 24 hr after the test was begun. (northwestern.edu)
  • The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor. (bvsalud.org)
Proteins1
  • The storage of erythrocytes causes changes in membrane proteins, which could be evidenced by proteomics. (unito.it)
Membrane2
  • C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex. (harvard.edu)
  • After identifying the most valid erythrocyte membrane extraction protocol and obtaining homogeneous protein samples by manual sonication, we performed Western blot assay (WB), by incubating the membranes with the primary anti beta-actin antibody and then with the anti-band 3 antibody. (unito.it)
Study aimed1
  • This study aimed to evaluate if blood loss and transfusion rate can be reduced in primary TKA by local application of TXA. (biomedcentral.com)
Methods1
  • Methods for measuring RBC mass are time consuming and expensive and usually require transfusion of radiolabeled erythrocytes. (medscape.com)
Patient1
  • One patient developed explosive diarrhea within 10 minutes after the start of transfusion. (cdc.gov)
Treatment1
  • The present results provide valuable information for future cost-effectiveness analyses focusing on disorders whose treatment involves routine RBC transfusion. (bvsalud.org)
Implications1
  • Erythrocyte ageing in vivo and in vitro: structural aspects and implications for transfusion. (ru.nl)
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