Exchange Transfusion, Whole Blood
Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
Blood Transfusion, Autologous
Blood Component Transfusion
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
Blood Transfusion, Intrauterine
Anion Exchange Protein 1, Erythrocyte
A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.
Blood Grouping and Crossmatching
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
Acute Kidney Injury
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A diverse family of extracellular proteins that bind to small hydrophobic molecules. They were originally characterized as transport proteins, however they may have additional roles such as taking part in the formation of macromolecular complexes with other proteins and binding to CELL SURFACE RECEPTORS.
Encyclopedias as Topic
Portraits as Topic
An enzyme that catalyzes the formation of glycerol 3-phosphate from ATP and glycerol. Dihydroxyacetone and L-glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway. EC 184.108.40.206.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Nitric Oxide Synthase
Blood Buffy Coat
Multiple Organ Failure
Members of a religious denomination founded in the United States during the late 19th century in which active evangelism is practiced, the imminent approach of the millennium is preached, and war and organized government authority in matters of conscience are strongly opposed (from American Heritage Dictionary of the English Language, 4th ed). Jehovah's Witnesses generally refuse blood transfusions and other blood-based treatments based on religious belief.
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Intrauterine management of fetal parvovirus B19 infection. (1/717)OBJECTIVES: The aim of our study was to determine the outcome of pregnancies after intrauterine management of fetal parvovirus B19 infection. DESIGN: Retrospective study. SUBJECTS: A total of 37 cases of maternofetal parvovirus B19 infection, 35 of which were associated with hydrops fetalis, were referred to our tertiary level center between 1989 and 1996. With regard to fetal hydrops, no apparent cause other than parvovirus B19 infection was found in any patient. METHODS: In all patients, cordocentesis was performed to assess the degree of fetal anemia. When anemia was present, cordocentesis was followed by intrauterine transfusion with packed red cells into the umbilical vein. Further management depended on the degree of fetal anemia and gestational age and included follow-up fetal blood sampling/transfusion as well as ultrasound examinations as deemed appropriate. RESULTS: Packed red cell transfusion was performed in 30 patients with significant fetal anemia (Z-score 1.6-7.8 below the mean for gestational age). The fetal hemoglobin values ranged from 2.1 to 9.6 g/dl. Serum levels of platelets in the transfusion group were 9-228 x 10(9)/l with Z-scores in the range of < 1 to 3.8 below the mean. During treatment and follow-up, there were five intrauterine deaths (13.5%), one neonatal death (2.7%) and 31 live births (83.8%). CONCLUSIONS: Fetal parvovirus infection can lead to marked anemia and hydrops formation. Cordocentesis allows precise assessment of fetal anemia which can then be corrected by intravenous transfusion. Under this regimen, the outcome proved favorable in the majority of fetuses, even those that were severely anemic. (+info)
Allogeneic stem cell transplantation for agnogenic myeloid metaplasia: a European Group for Blood and Marrow Transplantation, Societe Francaise de Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study. (2/717)Agnogenic myeloid metaplasia (AMM) is a chronic myeloproliferative disorder in which patients with poor prognostic features, receiving conventional treatments, have a median survival of less than 3 years. In this retrospective multicenter study, we analyze the results and try to define the indications for allogeneic stem cell transplantation in AMM. From January 1979 to November 1997, 55 patients with a median age of 42 years were transplanted from HLA-matched related (n = 49) or alternative (n = 6) donors for AMM. A multivariate analysis was conducted to identify factors associated with posttransplant outcome. The median posttransplant follow-up was 36 months (range, 6 to 223). The 5-year probability of survival was 47% +/- 8% for the overall group, and 54% +/- 8% for patients receiving an unmanipulated HLA-matched related transplant. The 1-year probability of transplant-related mortality was 27% +/- 6%. Hemoglobin level +info)
Survival of donor leukocyte subpopulations in immunocompetent transfusion recipients: frequent long-term microchimerism in severe trauma patients. (3/717)We recently reported detection of a transient increase in circulating donor leukocytes (WBCs) in immunocompetent recipients 3 to 5 days posttransfusion (tx) (Blood 85:1207, 1995). We have now characterized survival kinetics of specific donor WBC subsets in additional tx populations. Eight female elective surgery patients (pts) were sampled pre-tx and on days 1, 3, 5, 7, and 14 post-tx. Ten female trauma pts transfused with a total of 4 to 18 U of relatively fresh red blood cells were sampled up to 1.5 years post-tx. WBC subsets from frozen whole blood were isolated using CD4, CD8 (T cell), CD15 (myeloid), and CD19 (B cell) antibody-coated magnetic beads. Donor WBCs were counted by quantitative polymerase chain reaction (PCR) of male-specific sex determining region (SRY) sequences. PCR HLA typing and mixed leukocyte reaction (MLR) between recipient and donor WBCs were performed on two of the trauma tx recipients who had long-term chimerism of donor cells post-tx. In 6 of 8 female surgery pts, circulating CD4(+) male donor cells peaked at day 3 or 5 (0.01 to 1 cell/microL), followed by clearance by day 14. In 7 of 10 female trauma pts, we observed multilineage persistence of male donor WBCs (CD4, CD8, CD15, CD19) for 6 months to 1.5 years post-tx at concentrations of 10 to 100 cells/microL. In 2 trauma recipients studied, MLR showed no, or very low, response to WBC of the single donor implicated as the source of microchimerism by HLA typing. Establishment of long-term multilineage chimerism in trauma recipients is probably caused by engraftment of donor stem cells and mutual tolerance between recipient and donor leukocytes. A better understanding of factors determining clearance versus chimerism of transfused leukocytes is critical to prevention of alloimmunization and transfusion-induced graft-versus-host disease, and, potentially, to induction of tolerance for transplantation. (+info)
Acute normovolaemic haemodilution vs controlled hypotension for reducing the use of allogeneic blood in patients undergoing radical prostatectomy. (4/717)Blood loss in patients undergoing radical prostatectomy may be substantial. In a randomized, prospective study, we assessed two methods of reducing the need for allogeneic blood transfusion with regard to efficacy and costs. Sixty patients undergoing retropubic radical prostatectomy were allocated randomly to one of three groups. In group 1 (n = 20), acute normovolaemic haemodilution (ANH) was initiated after induction of anaesthesia; autologous blood 15 ml kg-1 was withdrawn and replaced by colloid solutions (gelatin) to maintain haemodynamic stability. In group 2 (n = 20), controlled hypotension was established using sodium nitroprusside (target mean arterial pressure (MAP) approximately 50 mm Hg). Group 3 (n = 20), without manipulations, served as a control group. Troponin T (TnT), a sensitive marker for myocardial ischaemia, and various coagulation variables were measured in the perioperative period. Packed red blood cells (PRBC) were given when haemoglobin concentration was less than 7 g dl-1. Cost calculations did not include hospital overhead costs or staff costs. In the ANH group, mean 1278 (SD 150) ml of autologous blood were withdrawn. Significantly more volume was infused in the ANH patients (gelatin 2450 (550) ml) than in the two other groups. Coagulation data (platelet count, activated partial thromboplastin time (aPTT), fibrinogen, antithrombin III (AT III), D-dimers) did not differ significantly between the three groups. The hypotension group had significantly lower blood loss (1260 (570) ml), whereas the ANH (1820 (680) ml) and control group (1920 (590) ml) did not differ significantly. Patients in the hypotension group needed significantly less PRBC (total 14 units; 75% of patients did not need PRBC) than the ANH (total 21 units; 55% of patients did not need PRBC) or control patients (total 28 units; 40% of patients did not need PRBC). Total costs were lowest in the hypotension group (41% less than in the control patients) (P < 0.05). We conclude that the use of hypotension during radical prostatectomy resulted in approximately 40% reduction in total transfusion costs. ANH was less effective and more costly than controlled hypotension. (+info)
Kinetics of peroxidases in guinea pig bone marrow under immunostimulation. (5/717)Eosinophil peroxidase and myeloperoxidase play an important role in the host defense. Both enzymes are present in bone marrow, synthesized by blood progenitor cells. This research investigated the kinetic properties of peroxidases under immunostimulation in guinea pig bone marrow. Results suggest that there are at least two myeloperoxidase isozymes and at least three eosinophil peroxidase isozymes in guinea pig bone marrow and that some of these isozymes are expressed upon immunostimulation. (+info)
Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports. (6/717)OBJECTIVE: To receive and collate reports of death or major complications of transfusion of blood or components. DESIGN: Haematologists were invited confidentially to report deaths and major complications after blood transfusion during October 1996 to September 1998. SETTING: Hospitals in United Kingdom and Ireland. SUBJECTS: Patients who died or experienced serious complications, as defined below, associated with transfusion of red cells, platelets, fresh frozen plasma, or cryoprecipitate. MAIN OUTCOME MEASURES: Death, "wrong" blood transfused to patient, acute and delayed transfusion reactions, transfusion related acute lung injury, transfusion associated graft versus host disease, post-transfusion purpura, and infection transmitted by transfusion. Circumstances relating to these cases and relative frequency of complications. RESULTS: Over 24 months, 366 cases were reported, of which 191 (52%) were "wrong blood to patient" episodes. Analysis of these revealed multiple errors of identification, often beginning when blood was collected from the blood bank. There were 22 deaths from all causes, including three from ABO incompatibility. There were 12 infections: four bacterial (one fatal), seven viral, and one fatal case of malaria. During the second 12 months, 164/424 hospitals (39%) submitted a "nil to report" return. CONCLUSIONS: Transfusion is now extremely safe, but vigilance is needed to ensure correct identification of blood and patient. Staff education should include awareness of ABO incompatibility and bacterial contamination as causes of life threatening reactions to blood. (+info)
Epoetin alpha prevents anaemia and reduces transfusion requirements in patients undergoing primarily platinum-based chemotherapy for small cell lung cancer. (7/717)Anaemia commonly occurs in cancer patients receiving chemotherapy, often necessitating blood transfusion. This multicentre study was designed to evaluate the efficacy and safety of epoetin alpha in preventing the decline in haemoglobin (Hb) level, and to determine whether the transfusion requirement could be reduced, in patients receiving 4-6 cycles of primarily platinum-based combination cyclic chemotherapy for small cell lung cancer (SCLC). A total of 130 non-anaemic SCLC patients were randomized to receive no additional treatment (n = 44), epoetin alpha 150 IU kg(-1) subcutaneously (s.c.) three times a week (n = 42) or 300 IU kg(-1) s.c. three times a week (n = 44). Reductions in epoetin alpha dosage were made during the study if Hb level increased to >15 g dl(-1). The mean weekly dosage was 335 and 612 IU kg(-1), respectively, in the two active treatment groups. Significantly fewer (P < 0.05) epoetin alpha-treated patients experienced anaemia (Hb < 10 g dl(-1)) during the course of chemotherapy (300 IU kg(-1), 39%; 150 IU kg(-1), 48%; untreated, 66%). This was reflected in the significantly lower number of treated patients transfused [300 IU kg(-1), 20% (P< 0.001); 150 IU kg(-1), 45% (P< 0.05); untreated, 59%]. Epoetin alpha was well-tolerated, and there was no evidence of sustained, clinically significant, hypertension. In summary, epoetin alpha is effective and well-tolerated in maintaining Hb level and reducing transfusion requirement in patients undergoing cyclic chemotherapy for SCLC. (+info)
Early IL-12 p70, but not p40, production by splenic macrophages correlates with host resistance to blood-stage Plasmodium chabaudi AS malaria. (8/717)In this study, we compared synthesis of IL-12, a potent Th1-inducing cytokine, by splenic macrophages recovered from resistant C57Bl/6 (B6) mice, which develop predominantly Th1 responses, and susceptible A/J mice that mount primarily Th2 responses during early Plasmodium chabaudi AS infection. Quantitative analysis of IL-12 p40 and p70 release by ELISA revealed significant differences between resistant B6 and susceptible A/J mice in the synthesis of biologically active IL-12 p70, but not p40, by splenic macrophages during early blood-stage P. chabaudi AS infection. Despite up-regulation in p40 and p35 mRNA levels, spontaneous release of p40 in vitro by splenic macrophages was not significantly increased following infection in either mouse strain. In contrast, spontaneous release of p70 by splenic macrophages was increased in cells from B6 mice and levels were significantly higher compared with A/J mice. Furthermore, compared with infected A/J hosts, splenic macrophages recovered from infected B6 mice produced significantly greater quantities of IL-12 p70, but not p40, in vitro, following stimulation with lipopolysaccharide (LPS) or malaria parasite antigen (PRBC). Moreover, we found significant increases in the percentage of macrophages earlier in the spleens of infected B6 mice that could further contribute to differences in total p70 levels in vivo. Taken together, these data suggest that macrophage IL-12 synthesis may contribute to the polarization of Th responses seen in resistant B6 and susceptible A/J mice during acute blood-stage malaria. (+info)
Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with...
Many people diagnosed with haematological malignancies experience anaemia, and red blood cell (RBC) transfusion plays an essential supportive role in their management. Different strategies have been developed for RBC transfusions. A restrictive transfusion strategy seeks to maintain a lower haemoglobin level (usually between 70 g/L to 90 g/L) with a trigger for transfusion when the haemoglobin drops below 70 g/L), whereas a liberal transfusion strategy aims to maintain a higher haemoglobin (usually between 100 g/L to 120 g/L, with a threshold for transfusion when haemoglobin drops below 100 g/L). In people undergoing surgery or who have been admitted to intensive care a restrictive transfusion strategy has been shown to be safe and in some cases safer than a liberal transfusion strategy. However, it is not known whether it is safe in people with haematological malignancies.To determine the efficacy and safety of restrictive versus liberal RBC transfusion strategies for people diagnosed with
Liberal vs. Restrictive Transfusion Strategies: Are We Still Following the Results of the TRICC Trial? | Topics in Evidence...
A new randomized multicenter pilot study involving six ICUs in the United Kingdom was recently published in Critical Care Medicine journal.9 The authors in this study compared hemoglobin concentration (Hb), RBC use, and patient outcomes when restrictive or liberal blood transfusion strategies are used to treat anemic (Hb ≤ 90 g/L) critically ill patients of age ≥ 55 years requiring ≥ 4 days of mechanical ventilation in the ICU. One hundred patients were randomized to restrictive transfusion strategy targeting 71-90 g/L (n=51) and to liberal transfusion strategy targeting 91-110 g/L (n=49) for 14 days or the remainder of ICU stay, whichever was longest. ...
A restrictive policy for red blood cell transfusion in older hip fracture patients: experiences from a patient register
Background: Allogeneic red blood cell transfusions (ABT) are common in older hip fracture patients. Recent research supports a restrictive transfusion policy. The aim was to study variation in hemoglobin (Hb) concentration, and clinical outcomes in these patients.. Results: Cross-sectional study with one-year follow-up in an orthogeriatric unit. Data were obtained from a quality register with demographic and medical information collected by an interdisciplinary team. 106 (22 %) of the 491 patients admitted from September 2011 throughout September 2012 (76 % women, mean age 85 years) received ABT. When given ABT, 80 % had Hb ,80 g/l and mean Hb was 78 g/l. Mean Hb, regardless ABT, showed variation from 125 g/l (±16) on admission to 106 g/l (±17), 101 g/l (±16) and 102 g/l (±14) on 1st, 3rd and 5th postoperative day respectively. Patients with per-/subtrochanteric fractures more often received ABT than those with femur neck fractures (p , 0.001), 70 % of the patients receiving ABT had a ...
Systematic review of the use of fibrin sealant to minimize perioperative allogeneic blood transfusion<...
TY - JOUR. T1 - Systematic review of the use of fibrin sealant to minimize perioperative allogeneic blood transfusion. AU - Carless, Paul A.. AU - Anthony, Danielle M.. AU - Henry, D. A.. PY - 2002. Y1 - 2002. N2 - Background: Fibrin sealants have become popular in improving perioperative haemostasis and reducing the need for allogeneic red cell transfusion. Methods: A systematic review of randomized controlled trials was conducted to examine the efficacy of fibrin sealants in reducing perioperative blood loss and allogeneic red blood cell transfusion. Studies were identified by computer searches of Medline, Embase, Current Contents, the Cochrane Library, manufacturer websites (to January 2001), and bibliographic searches of published articles. Trials were eligible for inclusion if they involved adult elective surgery and reported quantitative data on blood loss, the proportion of patients exposed to allogeneic red cell transfusion and/or the volume of blood transfused. Results: Twelve trials ...
Transfusion Medicine - Choosing Wisely Canada
Indications for red blood transfusion depend on clinical assessment and the cause of the anemia. In a stable, non-bleeding patient, often a single unit of blood is adequate to relieve patient symptoms or to raise the hemoglobin to an acceptable level. Transfusions are associated with increased morbidity and mortality in high-risk hospitalized inpatients. Transfusion decisions should be influenced by symptoms and hemoglobin concentration. Single unit red cell transfusions should be the standard for non-bleeding, hospitalized patients. Additional units should only be prescribed after re-assessment of the patient and their hemoglobin value.. Sources:. Bracey AW, et al. Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome. Transfusion. 1999 Oct;39(10):1070-7. PMID: 10532600.. Carson JL, et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev. 2012 Apr 18;(4):CD002042. ...
Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. - Nataonline
transfusion of red blood cells in preterm infants. The data confirm a significant reduction of the number of transfused red blood cell units with a restrictive transfusion strategy. However, the infants in the restrictive transfusion group were more likely ...
Aneurysmal SubArachnoid Hemorrhage-Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial...
Transfusion threshold adherence will be described as the proportion of per protocol RBC transfusion events. A transfusion threshold event is defined as an occurrence which starts when a haemoglobin value is measured at or below the allocated threshold for the first time since the previous event and ends when one of the following occurs: (1) an RBC transfusion is administered; or (2) a repeat haemoglobin is obtained above the allocated threshold within 24 hours of the original measure.. Transfusion threshold non-adherence will be considered to have occurred with any of the following: (1) an RBC transfusion occurs before a transfusion threshold is crossed; or (2) in the liberal arm, a transfusion is not given following a threshold crossing. Transfusion threshold non-adherence will be considered a deviation if: (1) the early transfusion occurs within 5 g/L above the allocated threshold (eg, ≤105 g/L for the liberal arm or ≤85 g/L for the restrictive arm) or, (2) in the liberal arm, an RBC ...
Restrictive Versus Liberal Red Cell Transfusion Strategy in Orthopedic-Oncology Patients Undergoing Surgery - a Randomized...
The rationale for perioperative red blood cell (RBC) transfusion is based on the observation that anemia is an independent risk factor for morbidity and mortality after cardiac operations. However, transfusions have been associated with high rates of morbidity and mortality in critically ill patients, and some recent studies have shown worse outcomes, including increased occurrence of renal failure and infection, as well as respiratory, cardiac, and neurological complications, in transfused compared with non transfused patients after cardiac surgery. On the basis of past clinical observations, some authors have suggested that hematocrit should be maintained at around 30% and hemoglobin concentration at 10 g/dL. Recently, however, this hemoglobin threshold has been reconsidered because of recognized risks associated with transfusion and greater appreciation of the importance of individual physiological responses to anemia. In a comparative trial of 428 patients undergoing elective coronary artery ...
Adverse effects of small-volume red blood cell transfusions in the neonatal population. - Nuffield Department of Orthopaedics,...
BACKGROUND: Adverse transfusion reactions in the neonatal population are poorly understood and defined. The incidence and pattern of adverse effects due to red blood cell (RBC) transfusion are not well known, and there has been no systematic review of published adverse events. RBC transfusions continue to be linked to the development of morbidities unique to neonates, including chronic lung disease, retinopathy of prematurity, intraventricular haemorrhage and necrotising enterocolitis. Uncertainties about the exact nature of risks alongside benefits of RBC transfusion may contribute to evidence of widespread variation in neonatal RBC transfusion practice.Our review aims to describe clinical adverse effects attributed to small-volume (10-20 mL/kg) RBC transfusions and, where possible, their incidence rates in the neonatal population through the systematic identification of all relevant studies. METHODS: A comprehensive search of the following bibliographic databases will be performed: MEDLINE (PubMed
Delayed hemolytic transfusion reaction with hyperhemolysis after first red blood cell transfusion in child with beta...
BACKGROUND: Delayed hemolytic transfusion reaction (DHTR) can manifest with hyperhemolysis, a serious complication of red blood cell (RBC) transfusions. This has mostly been described in sickle cell anemia but occasionally in beta-thalassemia. Treatment is challenging; immunosuppressive medication has been reported to be useful by some but not others., CASE REPORT: A 1.5-year-old girl with homozygous beta-thalassemia was put on a regular RBC transfusion program because of anemia with stunted growth and abnormal bone development. After the first transfusion she developed DHTR with hyperhemolysis. Further RBC transfusions could not be avoided. Despite treatment with prednisone, immunoglobulins, rituximab, and azathioprine hemolysis continued. She received an allogeneic bone marrow transplantation after conditioning using cyclophosphamide, treosulfan, melfalan, and ATG. The transplantation was followed by treatment with cyclosporin A, methotrexate, and prednisone. Because of poor engraftment and ...
The effects of iron deficiency on red blood cell transfusion requirements in non-bleeding critically ill patients.
The effects of iron deficiency on red blood cell transfusion requirements in non-bleeding critically ill patients., Mustafa Said Aydogan, Muharrem Uçar, Aytaç Yücel, Bugra Karak
Red Blood Cell Transfusions for Pets - Bloody Brilliant
Many dogs and cats may benefit from red blood cell transfusions. Learn more about their blood types and transfusion medicine by reading this blog post.
Red Cell Transfusion
www.MOLUNA.de Red Cell Transfusion  - From Donor to Patient, Sandra J. Nance. Overview of Immunology, Nancy M. Heddle. Compatibility Testing For Red Blood Cell Components: Approaches and Limitations, Kathleen Sazama. Transfusion in the Face of Autoantibodies, Steven R. Sloan and Leslie E. Silberstein. Red Blood Cell Transfusion of the Immunocompromised Patient, Christopher P. Stowell. Red
Anaemia management with red Blood Cell transfusion to improve post-intensive care disability: a randomised controlled trial ...
Anaemia management with red Blood Cell transfusion to improve post-intensive care disability: a randomised controlled trial (The ABC post-intensive care trial ...
PRIME PubMed | Red blood cell transfusion for people undergoing hip fracture surger
PubMed journal article Red blood cell transfusion for people undergoing hip fracture surger were found in PRIME PubMed. Download Prime PubMed App to iPhone, iPad, or Android
Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease - Full Text View ...
BACKGROUND:. Red blood cell transfusions are an extremely common medical intervention in both the United States and worldwide; over 14 million units of blood are transfused in the United States. Between 60 and 70 percent of all blood is transfused in the surgical setting. Despite the common use of red blood cell transfusions, the threshold for transfusion has not been adequately evaluated and is very controversial. A decade ago, the standard of care was to administer a peri-operative transfusion whenever the hemoglobin (Hgb) level fell below 10 g/dl (the 10/30 rule). Concerns about the safety of blood, especially with respect to HIV and hepatitis, and the absence of data to support a 10 g/dl threshold led to the current standard of care, which is to administer blood transfusions based on the presence of symptoms, and not a specific Hgb/hematocrit level. However, there have not been any randomized clinical trials done with surgical patients that have tested the efficacy and safety of ...
Uptake | Blood transfusion | Guidance and guidelines | NICE
Neoh, K.; Gray, R.; Grant-Casey, J.; et al. National comparative audit of red blood cell transfusion practice in hospices: Recommendations for palliative care practice, Palliative Medicine, 33, 1, 102-108, 2019. https://doi.org/10.1177/ ...
Increased hospital costs associated with red blood cell transfusion
Background - Red blood cell (RBC) transfusion is independently associated in a dose-dependent manner with increased intensive care unit stay, total hospital length of stay, and hospital-acquired complications. Since little is known of the cost of these transfusion-associated adverse outcomes our aim was to determine the total hospital cost associated with RBC transfusion and to assess any dose-dependent relationship. Study Design and Methods - A retrospective cohort study of all multiday acute care inpatients discharged from a five hospital health service in Western Australia between July 2011 and June 2012 was conducted. Main outcome measures were incidence of RBC transfusion and mean inpatient hospital costs. Results - Of 89,996 multiday, acute care inpatient discharges, 4805 (5.3%) were transfused at least 1 unit of RBCs. After potential confounders were adjusted for, the mean inpatient cost was 1.83 times higher in the transfused group compared with the nontransfused group (95% confidence ...
Traumatic Brain Injury: Red Blood Cells Transfusion
Most trauma deaths are related to traumatic brain injury (TBI). Although the management of patients has improved, mortality remains unacceptably high, and half of survivors of moderate and severe TBI are left with major functional impairment. Current management guidelines are based on limited evidence and practice is highly variable. Most acutely ill patients with TBI will develop anemia, which may decrease oxygen delivery to a fragile brain. While clinical practice is moving towards transfusing at low hemoglobin (Hb) levels, experts have expressed concerns regarding restrictive strategies, which may adversely affect clinical outcomes in TBI. Our primary objective is to evaluate the effect of red blood cell (RBC) transfusion thresholds on neurological functional outcome. We hypothesize that a liberal transfusion strategy improves outcomes compared to a restrictive strategy.
Transfusion Overload | PSNet
Case Objectives Understand that the traditional transfusion thresholds of hemoglobin below 10 g/dL and hematocrit below 30% are not supported by the evidence. List the common serious adverse effects of transfusion. Describe the evidence supporting a more restrictive transfusion strategy. State what transfusion threshold should be used in hospitalized patients with and without coronary artery disease. Case & Commentary-Part 1:
Impact of Early Red Blood Cell Transfusion After Kidney Transplantation on De Novo HLA Sensitization in the Setting of...
Introduction:. HLA specific antibodies detection (HSA) and that of Donor Specific Antibodies (DSA) were revolutionized by the introduction of solid phase assays (Luminex®), therefore making these antibodies a powerful biomarker for humoral injuries to the allograft. Determinants of HSA development entail non-adherence to immunosuppressive drugs but also allosensitizing events such as red blood cell (RBC) transfusions. Recent works showed a higher incidence of DSA in transplanted patients following RBC transfusion events, but no specific data exist for AntiThymocyte Globulin (ATG) induction.. This work aims at assessing whether peri-transplant RBC transfusion resulted in post-transplant HLA sensitization, in the setting of ATG induction therapy.. Patients and methods:. All consecutive patients benefiting from a first ATG-induced kidney allograft between 2004 and 2014 at our center with no history of HLA immunization were included retrospectively, provided transfusion history and HSA history were ...
Amgen Oncology Highlights Upcoming Data Presentations at the 2007 European Conference on Clinical Oncology
Increased the risk of death when administered to target a hemoglobin of 12 g/dL in patients with active malignant disease receiving neither chemotherapy or radiation therapy. ESAs are not indicated for this population. Patients receiving ESAs pre-operatively for reduction of allogeneic red blood cell transfusions: A higher incidence of deep venous thrombosis was documented in patients receiving Epoetin alfa who were not receiving prophylactic anticoagulation. Aranesp(R) is not approved for this indication.. Aranesp is contraindicated in patients with uncontrolled hypertension.. About Vectibix. Vectibix(TM) is indicated for the treatment of EGFr-expressing, metastatic colorectal cancer with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens.. The effectiveness of Vectibix for the treatment of EGFr-expressing, metastatic colorectal cancer is based on progression-free survival. Currently no data are available that demonstrate an ...
Episode 140: Transfusion Triggers and The TRICS 3 Trial with David Mazer - ACCRAC Podcast
In this 140th episode I welcome Dr. David Mazer to the show. Dr. Mazer was the PI and first author on the TRICS 3 trial looking at liberal versus restrictive transfusion strategies in moderate to high risk cardiac surgery patients published in the NEJM in 2017. Dr. Mazer would like to add the following random recommendation: For a great combination of live jazz and good food and drinks in Toronto, check out the Jazz Bistro just up the street from St. Michaels Hospital.. Reference: https://www.nejm.org/doi/full/10.1056/NEJMoa1711818. Dr. Mazer can be reached at [email protected] ...
RANDOMIZED CLINICAL TRIAL COMPARING LIBERAL AND RESTRICTIVE RED BLOOD CELLS TRANSFUSION STRATEGIES IN SEVERE TRAUMATIC BRAIN...
Anemia is frequent among traumatic brain injured (TBI) patients, and it is associated with an increased risk of poor outcomes. The optimal hemoglobin (Hb) level
Red Blood Cell Transfusion | Annals of Internal Medicine | American College of Physicians
The conundrum is what clinical factors should influence the routine titrated transfusion decision. The largest trial evaluating transfusion thresholds used prespecified symptoms (such as chest pain, orthostatic hypotension, or tachycardia unresponsive to fluid resuscitation) (1), which we included in our guideline. Although this approach is based on a randomized trial, these symptoms will not apply to all clinical settings. We agree with the accompanying editorial (2) that other variables (such as fatigue, dyspnea, mechanical ventilation, or the use of low Svo2) are unproven. Unfortunately, there is no evidence to support other important individual patient laboratory and physiologic variables as the basis for transfusion decisions ...
TGF-β1 AND TNF-α AFTER RED BLOOD CELL TRANSFUSION IN COLORECTAL CANCER PATIENTS | Experimental oncology
Operations in patients with cancer are associated with blood transfusion to restore normal physiology. Blood transfusion can cause the immunomodulatory effect.
Supra-Plasma Expanders: The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions? - Fingerprint - Albert...
Fingerprint Dive into the research topics of Supra-Plasma Expanders: The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions?. Together they form a unique fingerprint. ...
A randomized study comparing leukocyte-depleted versus packed red cell transfusions in prospective cadaver renal allograft...
A randomized study comparing leukocyte-depleted versus packed red cell transfusions in prospective cadaver renal allograft recipients.
Restrictive RBC transfusion strategy non-inferior to liberal approach in cardiac surgery - PACE-CME
A restrictive RBC transfusion strategy with 7.5 g/dL as trigger was non-inferior to a strategy with 9.5 g/dL for mortality and major morbidity in patients undergoing cardiac surgery in TRICS III.
Quality statement 3: Reassessment after red blood cell transfusions | Blood transfusion | Quality standards | NICE
Evidence-based statements to deliver quality improvements in the general principles of blood transfusion in adults, young people and children over 1 year old
Postoperative red blood cell transfusion and morbid outcome in uncomplicated cardiac surgery patients | SpringerLink
To evaluate postoperative red blood cell (RBC) transfusion and its association with postoperative cardiac events and multiorgan morbidity in uncomplicated cardiac surgery patients. A cohort of 945 pat
What is the evidence for using hemostatic agents in surgery?<...
TY - CHAP. T1 - What is the evidence for using hemostatic agents in surgery?. AU - Erstad, Brian L. PY - 2005. Y1 - 2005. N2 - The pharmacological methods used to achieve systemic hemostasis have generated much discussion due to concerns of serious adverse effects (e.g., thromboembolic complications) and costs of therapy in addition to efficacy considerations. There are a limited number of well-controlled trials involving pharmacological hemostasis for spine surgery. In the largest doubleblinded randomized controlled trial to date involving spine surgery, there was a trend toward reduced homologous transfusion in patients receiving aprotinin, but the only statistically significant result (p,0.001) was a reduction in autologous red cell donations. The findings of this trial are important, since the investigators used a number of restrictive transfusion strategies (e.g., autologous donation, low hematocrit trigger for transfusion, blood-salvaging procedures with the exception of no cell saver) ...
Hematocrit as a predictor of preoperative transfusion-associated complications in spine surgery: A NSQIP study. | Physicians...
Preoperative optimization of medical comorbidities prior to spinal surgery is becoming an increasingly important intervention in decreasing postoperative complications and ensuring a satisfactory postoperative course. The treatment of preoperative anemia is based on guidelines made by the American College of Cardiology (ACC), which recommends packed red blood cell transfusion when hematocrit is less than 21% in patients without cardiovascular disease and 24% in patients with cardiovascular disease. The literature has yet to quantify the risk profile associated with preoperative pRBC transfusion ...
clinico | MedicalCRITERIA.com
The red blood cell transfusions should not be dictated by a single hemoglobin trigger but instead should be based on the patients risks of developing complications of inadequate oxygenation. Red blood cell transfusion is rarely indicated when the hemoglobin concentration is greater than 10 g/dL and is almost always indicated when it is less than 6 g/dL ...
Transfusion for hemoglobin above 7 g/dL: no benefit in septic shock (TRISS Trial) - PulmCCM
Blood transfusions have been a central component of protocols for care of severe sepsis and septic shock, ever since the single-center 2001 Rivers trial included them in its interventions. Any benefit (or harm) caused by red cell transfusion independently was unknowable, and so the therapy became standard care as part of the so-called sepsis bundle. The Surviving Sepsis guidelines have generally advised transfusion to a hematocrit of 30% or hemoglobin of 10 g/dL during the first 6 hours of septic shock if hypoperfusion (low central venous oxygenation) is present despite fluids and vasopressors.. However, the inclusion of red cell transfusion in sepsis bundles has been frequently challenged, based on the weak observational evidence for its benefit, compared to robust evidence from randomized trials showing transfusion above a hemoglobin of 7 g/dL is unhelpful generally. This finding has been shown in the critically ill (the TRICC trial), after hip surgery (FOCUS trial) and in non-critically ill ...
Conference Notes 9-10-2014 - ACMC EM
Experimenting with new format today. About 5 take home points for each lecture. Burns (visiting professor) Transfusion Safety. 1. In general, Less is More when you are considering transfusions. U.S. physicians transfuse more blood products than European and Canadian physicians due to individual practice variation being greater in the U.S. Recent studies have shown that increasing # of units transfused of any blood product correlates directly with increased mortality, length of stay and wound complications even when controlled for patients severity of illness.. 2. Patient outcomes are better with a transfusion threshold of HGB=7 rather than 8 or 10 unless a patient is having ACS. Harwood comment: Is 8 really better than 7 for ACS? Dr. Burns: Yes there is data that the mortality is less for ACS at a transfusion trigger of HGB=8 rather than 7. When you do transfuse, only transfuse a single unit and then re-assess before deciding to give a second unit.. 3. Transfusion trigger for normotensive upper ...
Guidelines on the management of anaemia and red cell transfusion in adult critically ill patients Clinical Practice Guidelines
Definitions:. Strength of Recommendations. Strong (grade 1): Strong recommendations (grade 1) are made when there is confidence that the benefits do or do not outweigh harm and burden. Grade 1 recommendations can be applied uniformly to most patients. Regard as recommend.. Weak (grade 2): Where the magnitude of benefit or not is less certain a weaker grade 2 recommendation is made. Grade 2 recommendations require judicious application to individual patients. Regard as suggest.. Quality of Evidence. (A) High: Further research is very unlikely to change confidence in the estimate of effect. Current evidence derived from randomised clinical trials without important limitations.. (B) Moderate: Further research may well have an important impact on confidence in the estimate of effect and may change the estimate. Current evidence derived from randomised clinical trials with important limitations (e.g., inconsistent results, imprecision - wide confidence intervals or methodological flaws - e.g., ...
1) E.A. Hod , S.L. Spitalnik; 7 June 2012; Stored red blood cell transfusions: Iron, inflammation, immunity, and infection; Transfus Clin Biol. 19 (2012) 84-89. 2) Eldad A. Hod, Steven L. Spitalnik; 15 APR 2011; Harmful effects of transfusion of older stored red blood cells: iron and inflammation; DOI: 10.1111/j.1537-2995.2011.03096.x. 3) Niels Liona,b,⁎, David Crettaza, Olivier Rubina, Jean-Daniel Tissota 4 November 2009, Stored red blood cells: A changing universe waiting for its map(s); J Proteomics, 2010 Jan 3;73(3):374-85. 4) Eldad A. Hod, Gary M. Brittenham, Genia B. Billote, Richard O. Francis, Yelena Z. Ginzburg, Jeanne E. Hendrickson, Jeffrey Jhang, Joseph Schwartz, Shruti Sharma, Sujit Sheth, Anthony N. Sireci, Hannah L. Stephens, Brie A. Stotler, Boguslaw S. Wojczyk, James C. Zimring and Steven L. Spitalnik; October 20, 2011; Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non − transferrin-bound iron; Blood. 2011 ...
Changing indications for red cell transfusion. - Radcliffe Department of Medicine
High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients<...
TY - JOUR. T1 - High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients. AU - Sambasivan, Chitra N.. AU - Kunio, Nicholas R.. AU - Nair, Prakash V.. AU - Zink, Karen A.. AU - Michalek, Joel E.. AU - Holcomb, John B.. AU - Schreiber, Martin. PY - 2011/8. Y1 - 2011/8. N2 - Background: Administration of high transfusion ratios in patients not requiring massive transfusion might be harmful. We aimed to determine the effect of high ratios of fresh frozen plasma (FFP) and platelets (PLT) to packed red blood cells (PRBC) in nonmassively transfused patients. Methods: Records of 1,788 transfused trauma patients who received 1:2 ratio of FFP:PRBCs or a ,1:2 ratio PLT:PRBCs had significantly decreased ICU-free days and ventilator-free days. Conclusions: FFP:PRBC and PLT:PRBC ratios were not associated with in-hospital mortality. Depending on the threshold analyzed, a high ratio of FFP:PRBC and PLT:PRBC transfusion was associated with fewer ...
American Association Of Veterinary Laboratory Diagnosticians | Anemia | Karl E. Jandrey, DVM, MAS, DAVCECC
The treatment of the anemic patient often requires accurate type and cross-matching of red blood cells and an effective adminstration plan. This lecture will focus on patient examplesand case-based discussions to understand which patient are good candidates for red blood cell transfusion, how to plan for appropriate transfusion therapy, and create a protocol for watchful administration. Transfusion reactions will be discussed and as well as the step on how to attempt to mitigate them.
Greater St. Louis Veterinary Medical Association | Anemia | Karl E. Jandrey, DVM, MAS, DAVCECC
The treatment of the anemic patient often requires accurate type and cross-matching of red blood cells and an effective adminstration plan. This lecture will focus on patient examplesand case-based discussions to understand which patient are good candidates for red blood cell transfusion, how to plan for appropriate transfusion therapy, and create a protocol for watchful administration. Transfusion reactions will be discussed and as well as the step on how to attempt to mitigate them.
Parkers Battle with ADA: Busy Bees**
On Monday, Parker went to the hospital for a series of blood tests and an ultra sound of his organs. Tuesday brought more blood tests and a red blood cell transfusion to help decrease the number of toxic metabolites in Parkers blood. Wednesday, again some more blood to check for antibodies prior to beginning his first of three IgG transfusions. Today, Parker had his second transfusion of IgG and tomorrow will be his third. We are hoping that the IgG is enough to combat the antibodies in his blood causing his ...
JENKINTOWN, Pa., March 5, 2007 - The National Comprehensive Cancer Network (NCCN) announces important updates to the NCCN Cancer- and Treatment-Related Anemia Guidelines. The NCCN Clinical Practice Guidelines in Oncology™ are widely recognized and applied as the standard of care in oncology in the United States in both the community and the academic practice settings. A significant issue the panel addressed was the results of a trial by Amgen, Inc. studying the use of Aranesp® (darbepoetin alfa) in patients with cancer-related anemia. In this large, multicenter, randomized, placebo-controlled study, darbepoetin failed to reduce red blood cell transfusions in patients with active cancer who have anemia but are not on chemotherapy or radiation therapy. The study also showed higher mortality in patients receiving darbepoetin. As a result, the NCCN panel added a statement to the Adverse Effects of Erythropoietic Therapy section of the guidelines. It states that, until new research evidence ...
Sublingual microcirculation does not reflect red blood cell transfusion thresholds in the intensive care unit-a prospective...
Hemoglobin (Hb) transfusion thresholds are established in intensive care units. A restrictive transfusion threshold (Hb 70-75 g/l) is recommended in septic patients, and a liberal transfusion threshold (Hb 90 g/l) for cardiogenic shock. It is unclear whether these historically adopted transfusion thresholds meet the challenges of individual patients. We evaluated microvascular flow index (MFI) and proportion of perfused vessels (PPV) in the sublingual microcirculation with CytoCam-IDF microscopy and near-infrared spectroscopy (NIRS). A study team-independent, treating intensivist assigned a total of 64 patients to 1 of 2 two transfusion thresholds, 43 patients to the Hb 75 g/l threshold and 21 patients to the Hb 90 g/l threshold, at a surgical intensive care unit. We performed microcirculatory measurements 1 h before and 1 h after transfusion of 1 unit of red blood cells. Microcirculatory flow variables correlated negatively with pre-transfusion flow variables (ΔMFI: ρ = − 0.821, p | 0.001; ΔPPV:
Duration of red blood cell storage and outcomes in pediatric cardiac surgery: an association found for pump prime blood.<...
TY - JOUR. T1 - Duration of red blood cell storage and outcomes in pediatric cardiac surgery. T2 - an association found for pump prime blood.. AU - Ranucci, Marco. AU - Carlucci, Concetta. AU - Isgrò, Giuseppe. AU - Boncilli, Alessandra. AU - De Benedetti, Donatella. AU - De la Torre, Teresa. AU - Brozzi, Simonetta. AU - Frigiola, Alessandro. PY - 2009. Y1 - 2009. N2 - INTRODUCTION: Cardiac surgery using cardiopulmonary bypass in newborns, infants and small children often requires intraoperative red blood cell transfusions to prime the circuit and oxygenator and to replace blood lost during surgery. The purpose of this study was to investigate the influence of red blood cell storage time prior to transfusion on postoperative morbidity in pediatric cardiac operations. METHODS: One hundred ninety-two consecutive children aged five years or less who underwent cardiac operations using cardiopulmonary bypass and who received red blood cells for priming the cardiopulmonary bypass circuit comprised ...
Anemia, red blood cell transfusions, and necrotizing enterocolitis<...
TY - JOUR. T1 - Anemia, red blood cell transfusions, and necrotizing enterocolitis. AU - Maheshwari, Akhil. AU - Patel, Ravi M.. AU - Christensen, Robert D.. PY - 2018/2/1. Y1 - 2018/2/1. N2 - In the past 15 years, multiple clinical studies have identified a temporal association between red blood cell (RBC) transfusions and necrotizing enterocolitis (NEC). With some variability, most of these studies indicate that up to one-third of all cases of NEC involving very low-birth weight infants may occur within 24-48 h after receiving a RBC transfusion. There is also evidence that the risk of such transfusion-associated NEC may be higher in infants transfused with the greatest severity of anemia. In this article, we summarize the clinical evidence pertaining to these issues; specifically, the contribution of RBC transfusions, and the contribution of severity of underlying anemia, to the pathogenesis of a type of NEC potentially termed, transfusion/anemia-associated NEC.. AB - In the past 15 years, ...
Red blood cell concentrate transfusion strategies utilised at a tertiary-level paediatric intensive care unit: A descriptive...
Red blood cell concentrate transfusion strategies utilised at a tertiary-level paediatric intensive care unit: A descriptive study on impact and cost
Letter by Augoustides Regarding Article Aprotinin Does Not Increase the Risk of Renal Failure in Cardiac Surgery Patients |...
To the Editor:. I read with great interest the excellent article by Furnary and colleagues1 detailing an analysis of aprotinin and acute dialysis-dependent renal failure in cardiac surgery patients. Their multivariate analysis has demonstrated that increasing perioperative red blood cell transfusion, rather than aprotinin, is an independent risk factor for acute renal failure after cardiac surgery.. The data analysis as presented, however, does not account for angiotensin blockade in the presence of aprotinin, a described significant risk factor for perioperative renal injury.2 Consequently, if a significant percentage of the aprotinin cohort were exposed to angiotensin-converting enzyme inhibition, it might confound the results of the multivariate analysis. If the data for this variable are readily available, it would be interesting see if this potential confounder could have had any significant statistical effect.. Furthermore, the authors state in their discussion that meta-analysis of ...
Overuse of blood transfusions increases infection risk | Veterinary Sciences Tomorrow
by Vetscite. Blood transfusions are one of the most common procedures patients receive in the hospital but the more red blood cells they receive, the greater their risk of infection, says a new study led by the University of Michigan Heath System and VA Ann Arbor Healthcare System. Researchers analyzed 21 randomized controlled trials for the study that appears in Journal of the American Medical Association (JAMA). Elderly patients undergoing hip or knee surgeries were most susceptible, with a 30 percent lower risk of infection when fewer transfusions were used. Overall, for every 38 hospitalized patients considered for a red blood cell transfusion (RBC), one patient would be spared a serious infection if fewer transfusions were used. Transfusions are often used for anemia or during surgery to make up for blood loss. The authors evaluated all health care-associated infections that were reported after receiving donor blood in the randomized trials. These included serious infections such as ...
Abstract 14026: The Impact of Hemoglobin Drop, Bleeding Events and Blood Transfusion on Long Term Mortality Following...
Background: Despite the minimally invasive nature of trans-catheter aortic valve implantation (TAVI), the procedure is associated with several complications. We analyzed the individual impact of bleeding events, hemoglobin (Hb) drop, and Red Blood Cells (RBC) transfusions on prognosis.. Methods and results: Consecutive patients (n=597) undergoing trans-femoral TAVI were prospectively enrolled. Peri-procedural Hb levels, RBC transfusions and major/life threatening bleeding events were documented and analyzed. To study the relationship between Hb drop, RBC transfusions and long-term mortality, the entire cohort was divided into 4 groups according to Hb drop (less or ≥ than 3 g/dl), and receiving RBC transfusion (yes /no). In the entire cohort mean Hb level decreased following TAVI (11.8±1.4 to 9.5 ±1.3 g/dl; p,0.001). Major/ life threatening bleedings occurred in 66 (10.1%) patients, and 179 (30%) patients received RBC transfusions. Major/life threatening bleedings were not independently ...
Penn Vet | Clinical Trial - Effect of duration of red blood cell storage on transfusion-associated inflammation in dogs with...
The shelf-life of stored red blood cells (RBCs) is typically 42 and 35 days for human and canine RBCs, respectively. Given that blood is a precious and limited resource, both human and veterinary blood banks typically dispense the oldest RBC units first to reduce wastage. However, accumulating evidence suggests that transfusion of RBCs stored ≥ 14 days is associated with increased rates of morbidity and mortality in hospitalized human patients. In our study of healthy dogs receiving autologous RBC transfusions stored for 7 (fresh) and 28 (old) days, administration of old, but not fresh, RBC units was associated with a pro-inflammatory cytokine response, exemplified by monocyte chemoattractant protein (MCP)-1, and accompanied by increased neutrophil counts and decreased platelet counts.. We propose to evaluate markers of inflammation, hemolysis, and endothelial activation in a randomized clinical trial in which client-owned dogs with primary immune-mediated hemolytic anemia (IMHA) and ...
Defining transfusion triggers and utilization of fresh frozen plasma and platelets among patients undergoing...
TY - JOUR. T1 - Defining transfusion triggers and utilization of fresh frozen plasma and platelets among patients undergoing hepatopancreaticobiliary and colorectal surgery. AU - Ejaz, Aslam. AU - Frank, Steven M.. AU - Spolverato, Gaya. AU - Kim, Yuhree. AU - Pawlik, Timothy M.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Background: We sought to define the overall utilization of fresh frozen plasma (FFP) and platelets and the impact on perioperative outcomes among patients undergoing hepatopancreaticobiliary and colorectal resections, as well as analyze the utility of laboratory triggers in guiding transfusion practice. Methods: We identified 3027 patients undergoing pancreatic, hepatic, and colorectal resections between 2010 and 2013 at Johns Hopkins Hospital. Data on international normalized ratio (INR) and platelet counts that triggered the perioperative utilization of these non-RBC (red blood cell) products were obtained and analyzed. Results: Overall FFP and platelet transfusion rates were 8.9% ...
The Outcome of Preoperative Transfusion Guideline on Sickle Cell Disease Patients at King Fahd Hospital-Jeddah (KSA) | Open...
Background: We developed a local hospital preoperative transfusion guideline for sickle cell disease (SCD) patients to reduce the perioperative and the postoperative comp..
Blood Transfusion Guidelines | Atlantic Provinces Pediatric Hematology Oncology Network
Les directives sur les soinsde soutien ont été mises au point par des spécialistes en santé qualifiés des provinces atlantiques (médecins, pharmaciens, personnel infirmier et autres professionnels de santé) à laide de références fondées sur les preuves ou sur les pratiques exemplaires. Le format et le contenu des directives seront modifiés à loccasion dexamens et de révisions périodiques. Nous avons pris soin dassurer lexactitude de linformation. Toutefois, tout médecin ou professionnel de santé utilisant ces directives sera responsable de la vérification des doses et de ladministration des médicaments conformément aux formulaires, aux politiques et aux normes de soins reconnues au sein de son établissement.. Link to APPHON/ROHPPA French translated Blood Transfusion Guideline. The C17 Council is an organization composed of the institutionally appointed heads of the sixteen pediatric hematology, oncology, and stem cell transplant programs across Canada. They represent ...
The Impact of Uncross-Matched Blood Transfusion on the Need for Massive Transfusion and Mortality: Analysis of 5,166 Uncross...
The Impact of Uncross-Matched Blood Transfusion on the Need for Massive Transfusion and Mortality: Analysis of 5,166 Uncross-Matched Units Academic Article ...
The impact of an hematocrit of 20% during normothermic cardiopulmonary bypass for elective low risk coronary artery bypass...
Cardiopulmonary bypass (CPB) induces hemodilutional anemia, which frequently requires the transfusion of blood products. The objective of this study was to evaluate oxygen delivery and consumption and clinical outcome in low risk patients who were allocated to an hematocrit (Hct) of 20% versus 25% during normothermic CPB for elective coronary artery bypass graft (CABG) surgery. This study was a prospective, randomized and controlled trial. Patients were subjected to normothermic CPB (35 to 36°C) and were observed until discharge from the intensive care unit (ICU). Outcome measures were calculated whole body oxygen delivery, oxygen consumption and clinical outcome. A nonparametric multivariate analysis of variance for repeated measurements and small sample sizes was performed. In a total of 54 patients (25% Hct, n = 28; 20% Hct, n = 26), calculated oxygen delivery (p = 0.11), oxygen consumption (p = 0.06) and blood lactate (p = 0.60) were not significantly different between groups. Clinical outcomes
Results of a protocol of transfusion threshold and surgical technique on transfusion requirements in burn patients<...
TY - JOUR. T1 - Results of a protocol of transfusion threshold and surgical technique on transfusion requirements in burn patients. AU - OMara, Michael S.. AU - Hayetian, Fernando. AU - Slater, Harvey. AU - Goldfarb, I. William. AU - Tolchin, Eric. AU - Caushaj, Philip F.. PY - 2005/8/1. Y1 - 2005/8/1. N2 - Introduction: Blood loss and high rates of transfusion in burn centers remains an area of ongoing concern. Blood use brings the risk of infection, adverse reaction, and immunosuppression. Methods: A protocol to reduce blood loss and blood use was implemented. Analysis included 3-year periods before and after institution of the protocol. All patients were transfused for a hemoglobin below 8.0 gm/dL. Results: Operations per admission did not change during the two time periods (0.78 in each). Overall units transfused per operation decreased from 1.56 ± 0.06 to 1.25 ± 0.14 units after instituting the protocol (p , 0.05). Also, units transfused per admission decreased from 1.21 ± 0.15 to 0.96 ...
Individual Probability of Allogeneic Erythrocyte Transfusion in Elective Spine Surgery:The Predictive Model of Transfusion in...
Patients scheduled to undergo elective spine surgery were included. More than 50% of the patients had an American Society of Anesthesiologists physical status of II or III. Exclusion criteria were exclusive cervical spine surgery, one-level laminectomy, and polytrauma. Clinical management was at the discretion of the attending anesthesiologists and surgeons. In the operating room, patients were continuously monitored with electrocardioscopy, blood pressure monitoring, pulse oximetry, capnography, and esophageal temperature monitoring. A Bair Hugger device (Arizant, Eden Prairie, MN) was used, and fluids were warmed. Anesthesia was induced with propofol (1.5-2.5 mg/kg), sufentanil (15 μg), and atracurium (0.7 mg/kg) and was maintained by a continuous infusion of sufentanil and atracurium, with desflurane in a 50%-50% vol/vol O2-N2O gas mixture. The rate of the sufentanil infusion and the inspired concentration of desflurane were adjusted to maintain mean blood pressure between 50 and 70 mm Hg ...
Effects of erythrocytapheresis transfusion on the viscoelastic...
Effects of erythrocytapheresis transfusion on the viscoelasticity of sickle cell blood.: Red blood cells containing hemoglobin S are less deformable than normal
Results for: Subject:Erythrocyte Transfusion | EthicShare Community
Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege / Deutsche Gesellschaft für Sozialpädiatrie und Deutsche Gesellschaft für Kinderheilkunde ...
2018 ICD-10-CM Diagnosis Code E83.111: Hemochromatosis due to repeated red blood cell transfusions
Free, official coding info for 2018 ICD-10-CM E83.111 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Systematic Review and Meta-Analysis of Platelet Transfusion Data - Transfusion News
In the United States, over two million patients receive platelet transfusions each year either prophylactically to reduce the risk of bleeding or therapeutically to control active bleeding.. A new systematic review from 17 randomized clinical trials and 55 observational studies summarizes the platelet transfusion literature focusing on dosage, transfusion thresholds and clinical conditions. The new AABB platelet transfusion guidelines are based on this systematic review. The systematic review also highlights that further research, especially for invasive procedures, is needed to optimize the transfusion of platelets.. References ...
Duration of red blood cell storage and survival of transfused patients (CME) - Staff
Disquieting reports of increased complication and death rates after transfusions of red blood cells (RBCs) stored for more than 14 days prompted us to perform an observational retrospective cohort study of mortality in relation to storage time ...
Duration of red blood cell storage and survival of transfused patients (CME) - PublicationlistASM
Disquieting reports of increased complication and death rates after transfusions of red blood cells (RBCs) stored for more than 14 days prompted us to perform an observational retrospective cohort study of mortality in relation to storage time ...
Doctors are still working on a cure for MDS, though there are many ways to manage the disease. Patients with very low risk who do not need blood transfusions may be able to go without treatment for years, as long as they are checked regularly by a doctor. Other patients need more aggressive therapies. One treatment regimen that has worked for some patients is high doses of chemotherapy followed by a stem cell transplant. Other MDS treatments aim to reduce the need for blood transfusions, decrease the risk of infection and increase quality of life.. Blood transfusions - Some patients may need red cell to relieve symptoms of fatigue and shortness of breath. Blood transfusions increase the number of normal red blood cells in circulation, helping to relieve anemia. Platelet transfusions may be given to prevent or stop bleeding if platelet counts are very low.. During a transfusion, a technician will hang a bag containing the blood product you are receiving from a pole, then insert a narrow tube into ...
Effect of blood transfusion on recurrence of head and neck carcinoma : retrospective review and meta-analysis. | Base...
To study the effect of transfusion on recurrence of squamous cell carcinoma of the head and neck, we analyzed the records of 143 patients with stage 11 through N squamous cell carcinoma of the supraglottic larynx or hypopharynx for whom follow-up to recurrence or 5 years after surgical therapy was available. Variables studied were age, gender,...
TRISS - Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive...
Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled ...
Which is worse? Anemia or transfusion? - Manuel Fontes, MD | DUKEHealth JA
At the conclusion of this activity, participants should be able to:. • Understand acute anemia vs. chronic anemia. • Understand concerns of Liberal vs. Restrictive transfusion.. • Understand red blood cell storage lesions ...
Are blood transfusions from younger or female donors riskier? - ABC6 - Providence, RI and New Bedford, MA News, Weather
HealthDay News) -- Red blood cell transfusions from young or female donors may lead to lower survival rates for recipients, according to a new Canadian study.. These results are intriguing and suggest that if you require a transfusion, your clinical outcome may be affected by the blood donors age and sex, said the studys senior author, Dr. Dean Fergusson. Hes director of the clinical epidemiology program at the Ottawa Hospital in Canada.. However, it is important to remember that our study was observational in nature, which means it cannot be considered definitive evidence, Fergusson said.. The researchers looked at blood transfusions at Ottawa Hospital between 2006 and 2013. The researchers linked more than 30,000 blood recipients with almost 81,000 donors.. The recipients health was followed for an average of just over two years.. Getting red blood cells from a woman instead of a man was linked with an 8 percent greater risk of death from any cause per unit of blood transfused, the ...
Transfusion of banked red blood cells and the effects on hemorrheology and microvascular hemodynamics in anemic hematology...
BACKGROUND: The aim of this study was to investigate the effects of red blood cell (RBC) transfusion on the hemorrheologic properties and microcirculatory hemodynamics in anemic hematology outpatients receiving 2 to 4 RBC units of either fresh (leukoreduced storage for less than 1 week) or aged (leukoreduced storage for 3-4 weeks) RBCs.. STUDY DESIGN AND METHODS: Measurements were performed before and 30 minutes after RBC transfusion in hematology outpatients. Leukoreduced RBC suspensions were stored in saline-adenine-glucose-mannitol (SAGM) additive solution. Whole blood viscosity was measured using Couette low-shear viscometry, RBC deformability and aggregability were measured using laser-assisted optical rotational cell analysis, and microcirculatory density and perfusion were assessed using sidestream dark field imaging.. RESULTS: One group of patients (n = 10) received a median (interquartile range) of 3 (2-3) RBC bags that were stored for 7 (5-7) days (fresh) and the other group of ...
Use of blood transfusions may be halved for patients with blood poisoning | Department of Clinical Medicine | UiB
K1s Anne Berit Guttormsen and Brit Sjøbø from Haukeland University Hospital, published together with Nordic colleagues an article in the leading medical journal The New England Journal of Medicine which shows that blood transfusions can be halved in patients with sepsis.
Does erythrocyte blood transfusion prevent acute kidney injury? Propensity-matched case control analysis.
BACKGROUND: Acute kidney injury is a common occurrence in intensive care unit patients with a reported incidence of 11-67% and is associated with an increased risk of death. In other patient populations, erythrocyte transfusion has been associated wi
NCCN Guidelines for Patients® | Myelodysplastic Syndromes
43 NCCN Guidelines for Patients ® : Myelodysplastic Syndromes, 2018 5 Treatment guide Lower-risk MDS with anemia The goal is to increase red blood cell counts and lessen the need for red blood cell transfusions. Doctors often assess the response about 2 to 4 months after the start of treatment with lenalidomide. If tests do not show a treatment response, then your next options are the same as those listed for MDS without del(5q). If tests show a response, you should continue this treatment until it stops working or side effects get too severe. Over time, your doctor may lower the dose of lenalidomide to lessen the side effects. (See page 33 for more details about lenalidomide.) Treatment options for MDS without del(5q) If tests show serum EPO ≤500 mU/mL, treatment with blood cell growth factors is recommended. The two main options are epoetin alfa and darbepoetin alfa. These drugs are red blood cell growth factors- also called ESAs. ESAs act like EPO and stimulate the body to make more red ...
EPOGEN® treatment for patients with anemia due to chronic kidney disease (CKD) | EPOGEN® (epoetin alfa)
EPOGEN® (epoetin alfa) is used to treat a lower than normal number of red blood cells (anemia) caused by chronic kidney disease in patients on dialysis to reduce or avoid the need for red blood cell transfusions.
WHO | 10 facts on blood transfusion
Often transfusions are prescribed when simple and safe alternative treatments might be equally effective. As a result such a transfusion may not be necessary. An unnecessary transfusion exposes patients to the risk of infections such as HIV and hepatitis and adverse transfusion reactions.. ...
AABB Guidelines: RBC transfusion thresholds & storage | MDedge Hematology and Oncology
Copyright © 2020 Frontline Medical Communications Inc., Parsippany, NJ, USA. All rights reserved. Unauthorized use prohibited. The information provided is for educational purposes only. Use of this Web site is subject to the medical disclaimer.. ...
Massive transfusion - Oxford Medicine
♦ Treatment of anaemia has changed substantially since the early 1990s♦ Although massive transfusion may be necessary, trauma surgeons have modified their practice to provide aggressive control of haemorrhage, prevent hypothermia and acidosis, optimize haemodynamic management in intensive care units, and rationalize transfusion support in severely injured patients. The result has been an improvement in the outcomes of these patients♦ Given the importance of early intervention in the care of the injured, understanding the physiology and true indications for early massive transfusion in trauma care has the potential to save many lives.
Josefs Story : JosefWood.com
Finally, after months of waiting & hoping, Josef was diagnosed with idiopathic aplastic anemia. To date, in the last 8 months, hes had about 23 platelet transfusions & 8 red blood cell transfusions. We tried steroids twice in 5 day bouts, with no change except in his white cell count a little. After numerous times in the hospital attempting to put in an IV and having his veins burst due to the low platelets, we decided to graduate to a more secure mode; he had surgery to put in a port for his transfusions. Around this time we began seeing a naturopath/chiropractic on a weekly basis. She began adjusting Josef every week, put him on a strict gluten-free, low sugar, organic diet, and got him on a herb/supplement regimen. We tried to treat his body naturally but ran short on time due to the iron overload concern. A couple months later we finally had to move ahead with a treatment plan. In April 2008 we underwent an immunosuppresive therapy of ATG, cyclosporin & prednisone (chemotherapy). While ...
Luspatercept Effective in Patients with Lower-Risk Myelodysplastic Syndromes
Pivotal phase 3 data demonstrated treatment with luspatercept resulted in statistically significant increased red blood cell transfusion independence compared with placebo.
Immune Mediated Hemolytic Anemia - Find a Vet Specialist
Hospitalization, possibly with intensive care and red blood cell transfusions, may be necessary depending on the severity of the disease process. Supplemental oxygen therapy may be necessary. Your veterinarian may discuss discontinuing any recent medications which could trigger IMHA. If an infection is suspected, an appropriate medication for the infection will be given. High doses of steroid medications (such as prednisone or dexamethasone) are commonly given to help control the immune attack on the red blood cells. Additional immunosuppressive drugs may also be needed, especially in more severe cases. Because the red blood cell destruction can result in blood clots, anticoagulant drugs like aspirin may be needed. Newer advanced treatments like blood purification are being investigated and are sometimes recommended in severe cases.. Once immunosuppressive therapy is started, response to treatment is expected within 1 to7 days if the medications are effective. Additional medications are often ...
AMs Story - Transformed follicular treated with SCT including HD Bexxar
I was supposed to have had an exit interview to be released from SCCA on Friday, October 10, which was subsequently changed to Monday, October 13. However, my neutrophil counts have been bouncing around. From over 1.0, they fell to .56 last Friday (almost neutropenic), but bounced back up to .95 a day or two later. My platelet count has been steadily declining to 12,000 on Friday, but it bounced up to 20,000 a day later and then started falling again. Dr. Holmberg consequently indicated I should stay in Seattle and be monitored at SCCA another couple of weeks to October 24. She prescribed G-CSF yesterday, which brought my neutrophil and white count up to the normal range today. I also received a red blood cell transfusion today because my hematocrit had dropped to 26%. Although, it was up to 27% today before the transfusion, it has slowly but consistently trended downward. I also received today an IL-11 (Neumega) shot to encourage platelet growth. The dosage was based on body weight, and I ...
Red blood cell
... and the erythrocyte sedimentation rate. The blood type needs to be determined to prepare for a blood transfusion or an organ ... The cytoplasm of erythrocytes is rich in hemoglobin, an iron-containing biomolecule that can bind oxygen and is responsible for ... Red blood cells may be given as part of a blood transfusion. Blood may be donated from another person, or stored by the ... Before blood is given, a small sample of the recipient's blood is tested with the transfusion in a process known as cross- ...
"Entrez Gene: GYPE glycophorin E". Cartron JP, Rahuel C (1992). "Human erythrocyte glycophorins: protein and gene structure ... analyses". Transfusion Medicine Reviews. 6 (2): 63-92. doi:10.1016/S0887-7963(92)70158-8. PMID 1591491. Huang CH, Skov F, ...
... created by attaching peptides onto erythrocytes". Transfusion. 50 (3): 635-641. doi:10.1111/j.1537-2995.2009.02480.x. PMID ... The erythrocyte binding antigen 175 of P. falciparum recognises the terminal Neu5Ac(alpha 2-3)Gal-sequences of glycophorin A. ... V) human erythrocytes". Eur. J. Biochem. 184 (2): 337-44. doi:10.1111/j.1432-1033.1989.tb15024.x. PMID 2792104. Tate CG, Tanner ... 2002). "Transfusion support with RBCs from an Mk homozygote in a case of autoimmune hemolytic anemia following diphtheria- ...
Hemolytic disease of the newborn
Erythrocyte Alloimmunization and Pregnancy at eMedicine Moise Jr KJ (15 March 2018). "Intrauterine fetal transfusion of red ... Once a woman has antibodies, she is at high risk for a future transfusion reaction if she is in need of a blood transfusion. ... Transfusion Reactions at eMedicine "Fatalities Reported to FDA Following Blood Collection and Transfusion: Annual Summary for ... Mid- to late- pregnancy IUT - Intrauterine Transfusion (IUT) is done either by intraperitoneal transfusion (IPT) or intravenous ...
His blood had a double population of erythrocytes, which implied a homologous transfusion. He delivered a positive for blood ... "Vinokourov positive for transfusion, Astana quits Tour". Cyclingnews. 25 July 2007. "Versus Daily Reports, The 94th Tour de ...
... created by attaching peptides onto erythrocytes". Transfusion. 50 (3): 635-641. doi:10.1111/j.1537-2995.2009.02480.x. PMID ... Oliver C, Blake D, Henry S (2011). "In vivo neutralization of anti-A and successful transfusion of A antigen incompatible red ... Oliver C, Blake D, Henry S (2011). "Modeling transfusion reactions and predicting in vivo cell survival with kodecytes". ... Transfusion. 51 (8): 1723-1730. doi:10.1111/j.1537-2995.2010.03034.x. PMID 21303367. Hadac EM, Federspiel MJ, Chernyy E, ...
Raddon has been associated with severe transfusion reactions. Glycophorin B acts as a receptor for erythrocyte binding Ligand ( ... Baldwin ML, Barrasso C, Gavin J (1981). "The first example of a Raddon-like antibody as a cause of a transfusion reaction". ... Both anti-S and anti-s have been implicated in transfusion reactions and haemolytic disease of the newborn. Anti-M although ... There are ~80000 copies of glycophorin B per erythrocyte. Both glycophorin A and B are expressed on the renal endothelium and ...
... mainly transfusion either in the donor or in another person. Blood analysis is an important diagnostic tool available to ... to remove blood due to excess levels of iron or erythrocytes (red blood cells); or to collect blood for later uses, ...
Satchwell, T. J. (2016). "Erythrocyte invasion receptors for Plasmodium falciparum: new and old". Transfusion Medicine. 26 (2 ... The parasite can also alter the morphology of the erythrocyte, causing knobs on the erythrocyte membrane. Infected erythrocytes ... During erythrocyte invasion, merozoites release merozoite cap protein-1 (MCP1), apical membrane antigen 1 (AMA1), erythrocyte- ... to recognize and enter the host erythrocyte (red blood cell). The parasite first binds to the erythrocyte in a random ...
Induced stem cells
Stem Cell-Derived Erythrocytes as Upcoming Players in Blood Transfusion". Stem Cells. 30 (8): 1587-1596. doi:10.1002/stem.1136 ... RBC transfusion is necessary for many patients. However, to date the supply of RBCs remains labile. In addition, transfusion ... Transfusion of in vitro-generated RBCs or erythroblasts does not sufficiently protect against tumor formation. The aryl ... Ex vivo erythroid cell generation may provide alternative transfusion products to meet present and future clinical requirements ...
In 1881 he described platelets as a third element in blood after the erythrocytes and leucocytes. Platelets had been described ... In 1869 he noted the value of blood transfusions in treating anemia. ...
Function-spacer-lipid Kode construct
... created by attaching peptides onto erythrocytes". Transfusion. 50 (3): 635-641. doi:10.1111/j.1537-2995.2009.02480.x. PMID ... "Modeling transfusion reactions with kodecytes and enabling ABO incompatible transfusion with Function-Spacer-Lipid constructs ... Chesla, S; Henry, S; Eatz, R; Sinor, L (2010). "Solid phase syphilis test utilizing KODE technology". Transfusion. 50: 196A- ... Oliver, Caroline; Blake, Debbie; Henry, Stephen (2011). "In vivo neutralization of anti-A and successful transfusion of A ...
Duffy antigen system
This species' erythrocytes possess the Duffy antigen and this antigen is used as the receptor for P. vivax on the erythrocytes ... A Duffy negative blood recipient may have a transfusion reaction if the donor is Duffy positive. Since most Duffy-negative ... On erythrocytes, the Duffy antigen acts as a receptor for invasion by the human malarial parasites P. vivax and P. knowlesi. ... Erythrocytes expressing Fya had 41-50% lower binding of P. vivax compared with Fyb cells. Individuals with the Fy(a+b-) ...
"Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration". Anesthesia and ... in addition to the very high direct and indirect costs of transfusions, along with the increasing view that many transfusions ... For example, exchange transfusion of RBC in neonates calls for use of blood product that is five days old or less, to "ensure" ... Duran joined the Transfusion Service at the Barcelona Hospital at the start of the conflict, but the hospital was soon ...
G substitutions at codon 164 caused severe erythrocyte ADK deficiency. Two siblings had erythrocyte ADK deficiency, but one did ... At least two patients have exhibited neonatal icterus and splenomegaly and required blood transfusions due to this deficiency. ... Abrusci P, Chiarelli LR, Galizzi A, Fermo E, Bianchi P, Zanella A, Valentini G (August 2007). "Erythrocyte adenylate kinase ... Qualtieri, A.; Pedace, V.; Bisconte, MG.; Bria, M.; Gulino, B.; Andreoli, V.; Brancati, C. (Dec 1997). "Severe erythrocyte ...
This interaction mediates a principal invasion pathway into the erythrocytes. The partial resistance of erythrocytes lacking ... Antibodies to the Gerbich antigens have been associated with transfusion reactions and mild hemolytic disease of the newborn. ... adult liver and erythrocyte. In the non erythroid cell lines, expression is lower than in the erythrocyte and the protein is ... In the erythrocyte glycophorin C makes up ~4% of the membrane sialoglycoproteins. The average number of O linked chains is 12 ...
Samuel Mitja Rapoport
In World War II there was a great need of transfusions. Many scientists worked on an improvement of the defensibility of the ... His work focused on the water-electrolyte balance and the metabolism of the erythrocytes. He described the role of the 2,3- ... Rapoport detected the eminent importance of the ATP concentration for the survivability of the erythrocytes. ... and chemical changes of erythrocytes in stored blood. Blood preserved in sodium citrate, neutral, and acid citrate-glucose (ACD ...
The condition generally resolves itself with erythrocyte (red blood cell) turnover, although blood transfusions can be ...
Results can be unreliable in many circumstances, for example after blood loss, after surgery, blood transfusions, anemia, or ... high erythrocyte turnover; in the presence of chronic renal or liver disease; after administration of high-dose vitamin C; or ...
Furthermore, blood transfusion and administration of glucocorticoids relieve the severe anemia resulting from M. haemofelis ... This spontaneous alteration of phenotype seems to allow individuals to detach from erythrocytes by the alteration or ... Treatment usually includes the administration of doxycycline or enrofloxacin to quell the infection along with transfusion and ... M. haemofelis has been transmitted by transfusion and oral administration of infected blood. Males show a significant ...
Hemolytic disease of the newborn
IUT - Intrauterine Transfusion (IUT) is done either by intraperitoneal transfusion (IPT) or intravenous transfusion (IVT). ... Erythrocyte antigen status. Types (classified by serology). Types of HDN are classified by the type of antigens involved ... Transfusion Reactions. Once a woman has antibodies, she is at high risk for a future transfusion reaction if she is in ... Exchange transfusion - Exchange transfusion is used when bilirubin reaches either the high or medium risk lines on the nonogram ...
The Rh blood group antigens (MIM 111700) are associated with human erythrocyte membrane proteins of approximately 30 kD, the so ... Transfusion Clinique et Biologique. 13 (1-2): 139-46. doi:10.1016/j.tracli.2006.02.008. PMID 16564724. Ripoche P, Goossens D, ... Westhoff CM, Ferreri-Jacobia M, Mak DO, Foskett JK (Apr 2002). "Identification of the erythrocyte Rh blood group glycoprotein ... Dahl KN, Westhoff CM, Discher DE (Feb 2003). "Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual ...
Detection of foetal erythrocytes in maternal blood post partum with the fluorescence-activated cell sorter. American Journal of ... Up to 30 mL of foetal-maternal transfusion may take place with no significant signs or symptoms seen in either mother or foetus ... If the haemorrhage has already occurred and now stopped, an inutero transfusion of red cells to the foetus may be recommended. ... Fetomaternal Hemorrhage: Incidence, risk factors, time of occurrence, and clinical effects" Transfusion 1990; 30:344-357. ...
2009). "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte". Mol. Biochem ... Transfusion. 48 (6): 1164-8. doi:10.1111/j.1537-2995.2008.01683.x. PMID 18435676. S2CID 5795042. Wang S, Amidi F, Beall M, et ...
Transfusion. 1963 May-Jun; 3: 161-6. "IAGG Secretariat , Past Presidents". Iagg.info. Archived from the original on 2015-09-24 ... Danon became interested in the process of aging of erythrocytes, and joined the Israeli Association of Gerontology. In 1975 he ... His research during this period continued to focus on erythrocytes and thrombocytes, as well as the interaction between these ... His pearly research in the Institute's Electron Microscopy Laboratory involved the membrane structure of erythrocytes, their ...
Red blood cell
... and the erythrocyte sedimentation rate. The blood type needs to be determined to prepare for a blood transfusion or an organ ... Transfusion. Main article: Blood transfusion. Red blood cells may be given as part of a blood transfusion. Blood may be donated ... Red blood cells, also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek ... "Transfusion Medicine and Hemotherapy. 39 (5): 308-314. doi:10.1159/000342534. PMC 3678267. PMID 23801921.. CS1 maint: Uses ...
The use of Daratumumab can interfere with pre-blood transfusion tests, as CD38 is weakly expressed on the surface of ... This can be sidelined by either pretreatment of the erythrocytes with dithiothreitol (DTT) or by using an anti-CD38 antibody ... erythrocytes. Thus, a screening assay for irregular antibodies against red blood cell antigens or a direct immunoglobulin test ...
... parenteral iron and transfusion of erythrocytes are alternative plans for treatment of EEP. Some over-the-counter supplements ... Since FECH deficiency is associated with increased concentrations of protoporphyrin in erythrocytes, plasma, skin and liver, ... erythrocytes become unstable and injury to the skin is induced. A significant increase in the hepatobiliary excretion of ... erythrocytes), plasma, skin, and liver. The severity varies significantly from individual to individual. A clinically similar ...
Erythrocyte transfusions have been shown to be a successful measure in decreasing the appearance of the disease by trying to ... Unfortunately, having chronic erythrocyte transfusions, it can be extremely harmful to the body and can cause severe ... Photomutilation and transfusion dependent anemia are common complications. Liver disease is also observed in some cases ... treated with blood transfusion and iron chelation: lack of benefit from oral charcoal". Biomedical Chromatography. 12 (6): 350- ...
ABO blood group system
"Transfusion to blood group A and O patients of group B RBCs that have been enzymatically converted to group O.". Transfusion. ... The ABO blood group system is used to denote the presence of one, both, or neither of the A and B antigens on erythrocytes. In ... The first practical use of blood typing in transfusion was by an American physician Reuben Ottenberg in 1907. And the large- ... These two subgroups are not always interchangeable as far as transfusion is concerned, as some A2 individuals produce ...
Index of HIV/AIDS-related articles
... transfusion - translation - transmission - transplacental - treatment IND - triglycerides - tuberculin skin test (TST) - ... erythrocytes - etiology - exogenous - exotoxin - expanded access - experimental drug - expression system ...
... is also observed in the maturation of erythrocytes (a red blood cell) and the neutrophil (a type of white blood cell). The ...
ஏபிஓ குருதி குழு முறைமை - தமிழ் விக்கிப்பீடியா
"Irish Blood Transfusion Service - Irish Blood Group Type Frequency Distribution". Irish Blood Transfusion Service. பார்த்த நாள் ... Laine, R.A. and Rush, J.S. (1988) "Chemistry of Human Erythrocyte Polylactosamine Glycopeptides (Erythroglycans) as Related to ... Blood Transfusion Division, United States Army Medical Research Laboratory (1971). Selected contributions to the literature of ... குருதி மாற்றீட்டு ஒவ்வாமை (blood transfusion incompatibility) பற்றிப் பார்க்கும்போது, தனியாக இந்த ஏபிஓ இரத்த குழு முறைமை பற்றி ...
"Blood transfusion = Trasfusione del sangue. 15 (4): 357-364. doi:10.2450/2017.0320-16. PMC 5490732 . PMID 28665269Note: ... and the major flavoprotein in erythrocyte. The measurement of the activity coefficient of erythrocyte glutathione reductase ( ... "Improving the safety of whole blood-derived transfusion products with a riboflavin-based pathogen reduction technology" ...
A neutrophil with a segmented nucleus (center and surrounded by erythrocytes), the intra-cellular granules are visible in the ... so transfusion of granulocytes as a therapeutic strategy would confer a very short-lasting benefit. In addition, there are many ...
Blood transfusion with packed red blood cells (PRBC) may be indicated according to need. ... The T cell activated macrophages engulf erythrocytes, leukocytes, platelets, as well as their progenitor cells. Along with ...
Leiby DA (2011). "Transfusion-associated babesiosis: shouldn't we be ticked off?". Ann Intern Med. 155 (8): 556-7. doi:10.7326/ ... Babesia canis and B. bigemina are "large Babesia species" that form paired merozoites in the erythrocytes, commonly described ... In life-threatening cases, exchange transfusion is performed. In this procedure, the infected red blood cells are removed ... It develops in patients who live in or travel to an endemic area or receive a contaminated blood transfusion within the ...
One way hemolysin lyses erythrocytes is by forming pores in phospholipid bilayers. Other hemolysins lyse erythrocytes by ... a blood transfusion. In rare cases, the spleen must be removed because it filters blood and removes from the bloodstream dead ... Many hemolysins are pore-forming toxins (PFT), which are able to cause the lysis of erythrocytes, leukocytes, and platelets by ... Upon investigating sheep erythrocytes, its toxic mechanism was discovered to be the hydrolysis of a specific membrane lipid, ...
Magnesium in biology
... endodermis and transfusion parenchyma cells at different seasons of the year". Botanica Acta. 103: 415-423. doi:10.1111/j.1438- ... "Spectrochemical Analysis of Sodium, Potassium, Calcium, Magnesium, Copper, and Zinc in Normal Human Erythrocytes". Journal of ...
"Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration". Anesthesia and ... Kilduffe R, DeBakey M (1942). The blood bank and the technique and therapeutics of transfusion. St. Louis: The C.V.Mosby ... Opinions vary as to the best way to determine transfusion efficacy in a patient in vivo. In general, there are not yet any ... Transfusion. 52 (1): 108-17. doi:10.1111/j.1537-2995.2011.03239.x. hdl:10945/48003. PMID 21756261.. ...
ಮಲೇರಿಯಾ - ವಿಕಿಪೀಡಿಯ
Murphy S, Harrison T, Hamm H, Lomasney J, Mohandas N, Haldar K (2006). "Erythrocyte G protein as a novel target for malarial ... Marcucci C, Madjdpour C, Spahn D (2004). "Allogeneic blood transfusions: benefit, risks and clinical indications in countries ...
Of high risk in kidney transplants is rapid clumping, namely agglutination, of red blood cells (RBCs or erythrocytes), as an ... This is typical of minor blood group exposure (e.g. Kell) following allogenic blood transfusion or trauma during pregnancy. At ...
Relative polycythemia is an apparent rise of the erythrocyte level in the blood; however, the underlying cause is reduced blood ... undergoing twin-to-twin transfusion syndrome. ... concentrate the erythrocytes, and return them to the body. ... In secondary polycythemia, 6 to 8 million and occasionally 9 million erythrocytes may occur per cubic millimeter of blood. ...
Blood transfusionEdit. Blood transfusion is sometimes used to treat iron deficiency with hemodynamic instability. Sometimes ... erythrocytes) or hemoglobin. When the body lacks sufficient amounts of iron, production of the protein hemoglobin is reduced. ... Transfusion Medicine Reviews. 27 (4): 221-34. doi:10.1016/j.tmrv.2013.09.001. PMID 24135037.. ... transfusions are considered for people who have chronic iron deficiency or who will soon go to surgery, but even if such people ...
Principles of Transfusion Medicine Baltimore: Williams & Wilkins; 1990: 47-56 *^ Beutler E, et al. Bone marrow transplantation ... Beutler,E. Erythrocyte carbohydrate metabolism. In: Weinstein,I.M.; Beutler,E., eds. Mechanisms of Anemia in Man New York: ... This he accomplished by showing that two populations of erythrocytes exist in the blood of African American women who are ...
Symptomatic treatment can be given by blood transfusion, if there is marked anemia. A positive Coombs test is a relative ... Bosman GJ, Willekens FL, Werre JM (2005). "Erythrocyte aging: a more than superficial resemblance to apoptosis?". Cellular ... February 1998). "Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review". Biochimie. ...
Blood transfusion is not usually required.. *Class III Hemorrhage involves loss of 30-40% of circulating blood volume. The ... "18F-positron-emitting/fluorescent labeled erythrocytes allow imaging of internal hemorrhage in a murine intracranial ... Fluid resuscitation with crystalloid and blood transfusion are usually necessary.. *Class IV Hemorrhage involves loss of ,40% ... Deficiencies of platelet function may require platelet transfusion while deficiencies of clotting factors may require ...
Giant cell arteritis
Erythrocyte sedimentation rate, an inflammatory marker, ,60 mm/hour (normal 1-40 mm/hour). ...
The use of Daratumumab can interfere with pre-Blood transfusion tests, as CD38 is weakly expressed on the surface of ... This can be sidelined by either pretreatment of the erythrocytes with dithiothreitol (DTT) or by using an anti-CD38 antibody ... erythrocytes. Thus, a screening assay for irregular antibodies against red blood cell antigens or a direct immunoglobulin test ...
Erythrocyte sedimentation rate (ESR). *Cross-matching. Determination of blood type for blood transfusion or transplants ... Erythrocyte Sedimentation Rate. Indicates the time it takes for red blood cells to move down a tube. This shows signs of ...
Transfusion dependentEdit. Transfusion dependent anemia is a form of anemia where ongoing blood transfusion are required. ... Hereditary spherocytosis is a hereditary defect that results in defects in the RBC cell membrane, causing the erythrocytes ... Blood transfusionsEdit. Blood transfusions in those without symptoms is not recommended until the hemoglobin is below 60 to 80 ... Beta thalassemia may also result in transfusion dependence. Concerns from repeated blood transfusions include iron ...
ಕೆಂಪು ರಕ್ತ ಕಣ - ವಿಕಿಪೀಡಿಯ
Föller M, Huber SM, Lang F (2008). "Erythrocyte programmed cell death". IUBMB Life. 60 (10): 661-8. doi:10.1002/iub.106. PMID ... Transfusion Medicine Reviews. 14 (4): 364-74. doi:10.1053/tmrv.2000.16232. PMID 11055079.. Unknown parameter ,month=. ignored ( ... Ruud JT (1954). "Vertebrates without erythrocytes and blood pigment". Nature. 173 (4410): 848-50. doi:10.1038/173848a0. PMID ... Cohen, W. D. (1982). "The cytomorphic system of anucleate non-mammalian erythrocytes". Protoplasma. 113: 23. doi:10.1007/ ...
Results can be unreliable in many circumstances, for example after blood loss, after surgery, blood transfusions, anemia, or ... high erythrocyte turnover; in the presence of chronic renal or liver disease; after administration of high-dose vitamin C; or ...
Colorado tick fever
Evidence suggests viral presence in mature erythrocytes is a result of replication of the virus in hematopoitic erythrocyte ... However, rare cases of transmission from blood transfusions have been reported. The virus which causes Colorado tick fever may ... particularly erythrocytes, which explains how the virus is transmitted by ticks and also accounts for the incidence of ... transmission by blood transfusion. The disease develops from March to September, with the highest infections occurring in June ...
Exchange transfusions. Much like with phototherapy the level at which exchange transfusion should occur depends on the ... Harrison, K. L. (1979). "Fetal Erythrocyte Lifespan". Journal of Paediatrics and Child Health. 15 (2): 96-97. doi:10.1111/j. ... Exchange transfusions performed to lower high bilirubin levels are an aggressive treatment. ... or exchange transfusions. In those who are born early more aggressive treatment tends to be required. Physiologic ...
... which can be discussed under the terms erythrocyte deformability and erythrocyte aggregation. Because of that, blood behaves as ... Effects of Erythrocytapheresis Transfusion on the Viscoelasticity of Sickle Cell Blood, Clinical Hemorheology and ... This effect is generated in the concentration entrance length of the tube, in which erythrocytes move towards the central ... April 2010). "Cardiovascular risks of anemia correction with erythrocyte stimulating agents: should blood viscosity be ...
The T cell activated macrophages engulf erythrocytes, leukocytes, platelets, as well as their progenitor cells. Along with ... Blood transfusion (PRBC) may be indicated according to need. ReferencesEdit. *^ Kossenko MM, Akleyev AA, Degteva MO, Kozheurov ...
Schizonts next form merozoites that break out of the macrophage cells and infect the red blood cells (erythrocytes). The ... and often blood transfusion. ... erythrocytes that have phagocytized merozoites) can be seen on ...
Mapping Rare Erythrocyte Phenotypes in Morocco: A Tool to Overcome Transfusion Challenges
... and clinical studies related to all aspects of blood transfusion. ... Journal of Blood Transfusion is a peer-reviewed, Open Access ... Mapping Rare Erythrocyte Phenotypes in Morocco: A Tool to Overcome Transfusion Challenges. A. Benahadi,1,2 S. Boulahdid,1,2 B. ... J. J. Lefrêre and P. Rouger, Pratique Nouvelle de la Transfusion Sanguine, Elsevier Masson, 2nd edition, 2006. ... C. T. Tagny, S. Owusu-Ofori, D. Mbanya, and V. Deneys, "The blood donor in sub-Saharan Africa: a review," Transfusion Medicine ...
Results for: Subject:Erythrocyte Transfusion | EthicShare Community
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine (1) ... Extent of physicians explanation regarding transfusions--risk of infection in donor blood transfusions must be considered] ... Transfusion medicine (Oxford, England) (3). *American journal of kidney diseases : the official journal of the National Kidney ... 3. Update: Yersinia enterocolitica bacteremia and endotoxin shock associated with red blood cell transfusions--United States, ...
Does erythrocyte blood transfusion prevent acute kidney injury? Propensity-matched case control analysis.
In other patient populations, erythrocyte transfusion has been associated wi ... CONCLUSIONS: Transfusion of erythrocytes to patients with acute lung injury had no effect on the development of acute kidney ... Erythrocyte Transfusion / adverse effects, methods*. Female. Humans. Kidney Failure, Acute / blood, etiology*, prevention & ... The purpose of this study was to determine the effect of erythrocyte transfusion on the development of acute kidney injury. ...
Blood transfusion promotes cancer progression: a critical role for aged erythrocytes
Further studies should address mediating mechanisms through which erythrocytes storage duration can impact the rate of ... transfusion of fresh blood is less harmful than transfusion of stored blood in the context of progressing malignancies. ... Blood transfusion promotes cancer progression: a critical role for aged erythrocytes Anesthesiology. 2008 Dec;109(6):989-97. ... The effects of erythrocytes transfusion in the MADB106 model emerged immediately and dissipated within 24 h. ...
The Release of Erythrocyte Membrane Antigens to the Plasma as Membrane Microvesicles during the Storage of Human Blood for...
... of Erythrocyte Membrane Antigens to the Plasma as Membrane Microvesicles during the Storage of Human Blood for Transfusion ... WENDY F. COLE, MARTIN G. RUMSBY, GEORGE H. LONGSTER, L. A. DERRICK TOVEY; The Release of Erythrocyte Membrane Antigens to the ... Plasma as Membrane Microvesicles during the Storage of Human Blood for Transfusion. Biochem Soc Trans 1 December 1978; 6 (6): ...
Pretransfusion Testing and Transfusion of Uncrossmatched Erythrocytes | Anesthesiology | ASA Publications
Individual Probability of Allogeneic Erythrocyte Transfusion in Elective Spine Surgery: The Predictive Model of Transfusion in ... Pretransfusion Testing and Transfusion of Uncrossmatched Erythrocytes Michael L. Boisen, M.D.; Ryan A. Collins, M.D.; Mark H. ... Pretransfusion Testing and Transfusion of Uncrossmatched Erythrocytes You will receive an email whenever this article is ... Because group O erythrocytes do not express A or B antigens, ABO-incompatibility hemolytic transfusion reactions are avoided. ...
Erythrocyte transfusions in neonates: is it safe to co-infuse dextrose-containing solutions? | ADC Fetal & Neonatal Edition
Erythrocyte transfusions in neonates: is it safe to co-infuse dextrose-containing solutions? ... Erythrocyte transfusions in neonates: is it safe to co-infuse dextrose-containing solutions? ... When a neonate with only one intravenous tube needs a transfusion, a concern about hypoglycaemia during the transfusion raises ... receive one or more RBC transfusions and that the average transfused neonate receives 2.4 RBC transfusions during their stay in ...
The influence of different erythrocyte lysing procedures on flow cytometric determination of CD34+ cells in umbilical cord...
Transfusion Medicine" on DeepDyve, the largest online rental service for scholarly research with thousands of academic ... "The influence of different erythrocyte lysing procedures on flow cytometric determination of CD34+ cells in umbilical cord ... Transfusion Medicine, 8(2),. MLA. Cassens,, Gutensohn, Garritsen, Kelsch, Kuehnl, and Sibrowski. "The influence of different ... erythrocyte lysing procedures on flow cytometric determination of CD34+ cells in umbilical cord blood transplants." Transfusion ...
Erythrocyte Transfusion | REACH
"Erythrocyte Transfusion" by people in this website by year, and whether "Erythrocyte Transfusion" was a major or minor topic of ... "Erythrocyte Transfusion" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Erythrocyte Transfusion" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Erythrocyte Transfusion". ...
Erythrocyte Transfusion | Anesthesiology | American Society of Anesthesiologists
... "erythrocyte transfusion" is more likely to reflect consequences of the "actual" erythrocyte transfusion than it was with the ... One of the next steps in transfusion research could be to better define the patients requiring erythrocyte transfusion, because ... Erythrocyte Transfusion: Remedy or Poison? Yannick Le Manach, M.D., Ph.D.; Yannick Le Manach, M.D., Ph.D. ... 1used an alternative approach to estimate the impact of erythrocyte transfusion based on the rate of transfusion observed in ...
Blood transfusion - Wikipedia
"Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration". Anesthesia and ... Transfusion Evidence Library searchable source of evidence for transfusion medicine.. Blood Transfusion Societies. * ... Compatibility of ABO and Rh system for Red Cell (Erythrocyte) Transfusion. This chart shows possible matches in blood ... Red cell transfusion. Main article: Packed red blood cells. Historically, red blood cell transfusion was considered when ...
Estimate of the number of urea transport sites in erythrocyte ghosts using a hydrophobic mercurial | SpringerLink
Transfusion 22:70-71Google Scholar. *. Jay, A.W.L. 1975. Geometry of the human erythrocyte. Biophys. J. 15:205-222Google ... urea transport erythrocytes mercurials spin labels electron spin resonance hydrophobicity We would like to thank Kate Van ... Effects of calcium on potassium and water transport in human erythrocyte ghosts. Biochim. Biophys. Acta 363:226-239CrossRef ... Localization of erythrocyte membrane sulfhydryl groups essential for glucose transport. J. Gen. Physiol. 48:617-632Google ...
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes | PNAS
Human blood for routine culturing was obtained from the United Kingdom National Blood Transfusion service. Blood for analysis ... 1975) Erythrocyte receptors for (Plasmodium knowlesi) malaria: Duffy blood group determinants. Science 189(4202):561-563. ... Adaptation of the P. knowlesi A1 strain to continuous culture in human erythrocytes. (A) Strategy used to adapt the parasites ... 2011) Fy(a)/Fy(b) antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria. ...
Erythrocyte storage increases rates of NO and nitrite scavenging: Implications for transfusion-related toxicity
... Academic ... Storage of erythrocytes in blood banks is associated with biochemical and morphological changes to RBCs (red blood cells). It ... Significant loss of whole-blood nitrite was also observed in stable trauma patients after transfusion with 1 RBC unit, with the ... reactions between intact RBCs and NO and nitrite may contribute to mechanisms that lead to storage-lesion-related transfusion ...
Rapid removal of glycerol from frozen-thawed red blood cells - Lusianti - 2013 - Biotechnology Progress - Wiley Online Library
Hematology Archives - Nova Science Publishers
Exposure of stored packed erythrocytes to nitric oxide prevents transfusion-associated pulmonary hypertension. - Nataonline
Exposure of stored packed erythrocytes to nitric oxide prevents transfusion-associated pulmonary hypertension.. ... Reducing transfusions in critically injured patients using a restricted-criteria order set. ... Does the severity of preoperative anemia or blood transfusion have a stronger impact on long-term survival after cardiac ... before transfusion in a stable haemodynamic and non-inflammatory animal model. The authors show that pretreatment of older ...
Erythrocyte fragility - Wikipedia
Transfusion. 48 (6): 1188-1191. doi:10.1111/j.1537-2995.2008.01670.x. PMID 18346016. Vox Sang. 2010 Nov;99(4):325-31. The use ... Erythrocyte fragility refers to the propensity of erythrocytes (red blood cells, RBC) to hemolyse (rupture) under stress. It ... Uses of erythrocyte mechanical fragility can include diagnostic testing, calibrations to aid comparisons of hemolysis caused by ... For example, photons or radicals can induce hemolysis.Erythrocytes/RBC may also be tested for related membrane properties aside ...
Mechanism and Repository Study for the Red Cell Storage Duration Study - Full Text View - ClinicalTrials.gov
Cardiac Surgery Erythrocyte Transfusion Show Detailed Description Study Design. Go to Study Description Study Design Groups and ... and who received at least one RBC transfusion between randomization and 96 hours after the cardiac surgery ends ... and who received at least one RBC transfusion between randomization and 96 hours after the cardiac surgery ends ... each examine hypotheses addressing mechanisms potentially able to relate storage time to clinical outcomes in RBC transfusion ...
Table 1 - Severe Plasmodium vivax Malaria, Brazilian Amazon - Volume 16, Number 10-October 2010 - Emerging Infectious Diseases...
A Study to Determine the Efficacy and Safety of Luspatercept in Adults With Non Transfusion Dependent Beta (β)-Thalassemia -...
Red Blood Cell Transfusions. Erythrocyte transfusion. Hb increase. NTDT. Additional relevant MeSH terms:. Layout table for MeSH ... Subject must not be on a regular transfusion program and must be RBC transfusion-free for at least ≥ 8 weeks prior to ... The non-transfusion dependent β- thalassemia-patient reported outcome (NTDT-PRO) is administered as a daily diary for 24 weeks ... The non-transfusion dependent β- thalassemia-patient reported outcome (NTDT-PRO) is administered as a daily diary for 24 weeks ...
AAEM Resident and Student Association : I Was Just Filling up the Tank, Right? When Erythrocyte Transfusion Goes Awry
I Was Just Filling up the Tank, Right? When Erythrocyte Transfusion Goes Awry ... 1. Vamvakas EC, Taswell HF: Long-term survival after blood transfusion. Transfusion 1994; 4:471- 477. ... Allergic reactions to blood transfusion run the spectrum from isolated urticaria (1/100 transfusions) to full blown anaphylaxis ... However, the transfusion of blood and blood products is a hazardous activity, and we all agree that there are several dangers ...
Score for neonatal acute physiology and phlebotomy blood loss predict erythrocyte transfusions in premature infants<...
... of the infants given transfusions. Infants who were given transfusions vs those who were not given transfusions were of a lower ... of the infants given transfusions. Infants who were given transfusions vs those who were not given transfusions were of a lower ... of the infants given transfusions. Infants who were given transfusions vs those who were not given transfusions were of a lower ... of the infants given transfusions. Infants who were given transfusions vs those who were not given transfusions were of a lower ...
Frontiers | Erythrocyte Aging, Protection via Vesiculation: An Analysis Methodology via Oscillatory Flow | Physiology
We introduce a novel theoretical-simulation-experimental approach to subject erythrocytes to tailored shear deformations that, ... We introduce a novel theoretical-simulation-experimental approach to subject erythrocytes to tailored shear deformations that, ... Dumaswala, U. J., and Greenwalt, T. J. (1984). Human erythrocytes shed exotic vesicles in vivo. Transfusion 24, 490-492. doi: ... mechanistic pathway by which erythrocyte aging occurs and by which erythrocytes are removed. This process involves a general ...
Relationship of Erythrocyte Transfusion with Short- and Long-term Mortality in a Population-based Surgical Cohort |...
Erythrocyte transfusion has many side effects, ranging from mild (e.g ., febrile reactions) to serious (e.g ., transfusion- ... Thus, if transfusion is harmful, high-transfusion rate hospitals will be expected to have worse outcomes than low-transfusion ... at 66 hospitals with widely different erythrocyte transfusion rates was to explore the effects of erythrocyte transfusion on ... high-transfusion centers were lower-volume hospitals and had greater autologous erythrocyte, plasma, and platelet transfusions ...
December 2008 - Volume 65 - Issue 6 : Journal of Trauma and Acute Care Surgery
Early packed red blood cell trans... preview & related info | Mendeley
BACKGROUND: Transfusion of packed red blood cells (PRBCs) is a risk factor for acute respiratory distress syndrome (ARDS) in ... Early transfusion of PRBCs is an independent predictor of ARDS in adult trauma patients. Conservative transfusion strategies ... BACKGROUND: Transfusion of packed red blood cells (PRBCs) is a risk factor for acute respiratory distress syndrome (ARDS) in ... Early packed red blood cell transfusion and acute respiratory distress syndrome after trauma. *Chaiwat O ...
Frequency of dog erythrocyte antigen 1 blood group and risk of incompatible transfusion in dogs of different breeds and...
Full text: Available Index: LILACS (Americas) Main subject: Blood Transfusion / Dogs / Erythrocyte Indices Type of study: ... Full text: Available Index: LILACS (Americas) Main subject: Blood Transfusion / Dogs / Erythrocyte Indices Type of study: ... The dog erythrocyte antigen 1 (DEA 1) is the most immunogenic blood group in dogs, and blood transfusions may trigger some ... Frequency of dog erythrocyte antigen 1 blood group and risk of incompatible transfusion in dogs of different breeds and ...
Erythrocyte Transfusion and Alloimmunisation Patterns among Sickle Cell Disease Patients, Benin City, Nigeria | Journal...
Erythrocyte Transfusion and Alloimmunisation Patterns among Sickle Cell Disease Patients, Benin City, Nigeria * S. Ademola ... 74.5% of the subjects have a past history of blood transfusion. Four (7.3%) of the subjects had unexpected erythrocyte allo- ... Adewoyin, S. (2015). Erythrocyte Transfusion and Alloimmunisation Patterns among Sickle Cell Disease Patients, Benin City, ... The risk of alloimmunisation increased with total lifetime transfusions (p = 0.002). Conclusion: Erythrocyte alloimmunisation ...
The Iron Status of Very Low Birth Weight Infants Receiving Multiple Erythrocyte Transfusions during Hospitalization in the...
A total of 38 (82.6%) of very low birth weight infants received a mean volume of 99.3+/-93.5 mL of erythrocyte transfusions in ... erythrocyte transfusions (p=0.026 and p=0.022, respectively). Infants with morbidity including bronchopulmonary dysplasia or ... We collected individual data of the frequency and volume of erythrocyte transfusion and the amount of iron intake. RESULTS:. ... Bronchopulmonary Dysplasia , Erythrocyte Transfusion , Ferritins , Hospitalization , Humans , Infant , Infant, Newborn , Infant ...
Cell transfusionErythropoietinInstitute for Transfusion MedicineRegular Blood TransfusionsAnemiaHistory of blood transfusionImpact of erythrocyte transfusionHumansMortalityReceive transfusionsNeonatalEffect of the transfusionPost-transfusion survivalAcute lung iCONCLUSIONSMedicineComponent TransfusionDonorRestrictivePlateletPatientsHemoglobin levelAutologousPlateletsExchange transfusionAntigenAntibodiesInfantsRBCsCoagulationAllogeneicOutcomesSurvivalObservationalClinicalDeformabilityNeonatesCentersMembraneNitric oxideTherapy1991FragilityRisksAntigensBlood cellsFrequencyIntensive careErythropoiesis
- Consensus statement on red cell transfusion. (ethicshare.org)
- Fontanals M, O'Leary JD, Zaarour C, Skelton T, Faraoni D. Preoperative anemia increases the risk of red blood cell transfusion and prolonged hospital length of stay in children undergoing spine arthrodesis surgery. (sickkids.ca)
- Roumeliotis N, Ducruet T, Bateman ST, Randolph AG, Lacroix J, Emeriaud G. Determinants of red blood cell transfusion in pediatric trauma patients admitted to the intensive care unit. (sickkids.ca)
- 4. Consensus Conference on Perioperative Red Blood Cell Transfusion. (blogspot.com)
- There is need to upgrade local/regional transfusion services to include routine allo-antibody screening/identification as part of precompatibility testing particularly SCD patients who have received more than 10 units of red cell transfusion. (journaljammr.com)
- HCV presence in immunocomplexes immunoadhering on the erythrocytes might explain the association between HCV infection and red cell transfusion. (elsevier.com)
- OBJECTIVE To examine the number and volume of red blood cell transfusions (RBCTs) in very and extremely low birthweight infants under restrictive red blood cell transfusion guidelines without erythropoietin administration, and to compare the results with those reported in similar infants receiving erythropoietin. (bmj.com)
- Autologous blood transfusion with recombinant erythropoietin treatment. (biomedsearch.com)
- As earlier treatment with recombinant human erythropoietin may be more efficacious, early identification of which infants currently undergo transfusion may identify those who will receive the greatest benefit from recombinant human erythropoietin therapy. (elsevier.com)
- Red blood cell transfusions in very and extremely low birthweight infants under restrictive transfusion guidelines: is exogenous erythropoietin necessary? (bmj.com)
- Erythropoietin therapy for prevention and treatment of anaemia of prematurity is still not generally recommended, 11 although it has been shown to effectively stimulate erythropoiesis in vitro 12 13 and in vivo, 14-18 and was shown to be effective in reducing the need for transfusion in various age groups of preterm infants. (bmj.com)
- 14 16 17 19-22 Studies have been criticised for examining relatively large preterm infants or those in a stable condition, or for giving transfusions to maintain packed cell volume at unusually high levels, thereby showing an effect of erythropoietin in infants who may not need to be transfused at all. (bmj.com)
- The process of increasing the number of circulating red blood cells in order to increase the oxygen-carrying capacity of the blood for improved athletic endurance, performed by blood transfusion or administering erythropoietin. (thefreedictionary.com)
- Response to treatment with erythropoietin +/- granulocyte colony-stimulating factor (G-CSF) is associated with improved QoL, but whether transfusion therapy with higher haemoglobin (Hb) target levels has similar effects is unknown. (diva-portal.org)
Institute for Transfusion Medicine1
- Department of Pathology, University of Pittsburgh and Institute for Transfusion Medicine, Pittsburgh, Pennsylvania (M.H.Y. (asahq.org)
Regular Blood Transfusions1
- The majority of β-thalassemia patients depend on regular blood transfusions combined with iron chelation therapy for their survival. (termedia.pl)
- Recommendations on RBC Transfusion in Infants and Children With Acquired and Congenital Heart Disease From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. (sickkids.ca)
-  The advisory caution to use blood transfusion only with more severe anemia is in part due to evidence that outcomes are worsened if larger amounts are given. (wikipedia.org)
- To evaluate the effect of luspatercept in non-transfusion dependent β-thalassemia-patient versus placebo on anemia, as measured by mean hemoglobin concentration in the absence of transfusions over a continuous 12-week interval, from Week 13 to Week 24, compared to baseline. (clinicaltrials.gov)
- Erythrocyte growth factors can help relieve the symptoms of anemia including weakness, dizziness and fatigue. (cancer.ca)
- One of the most common is sickle cell anemia, which, due to sickling of erythrocytes, causes vaso-occlusive phenomena. (scielo.br)
- When the blood of one of the patients was subjected to the action of hypotonic salt solution, the oval cells resembled normal erythrocytes in their behavior rather than the poikilocytes of a patient with anemia. (annals.org)
- Luspatercept has been used in trials studying the treatment of Anemia, Beta-Thalassemia, Erythrocyte Transfusion, and Myelodysplastic Syndromes. (drugbank.ca)
- Prolonged Severe Anemia and Transfusion Refusal Following Abdominal Surgery. (omicsonline.org)
- Mura P, Deiana M, Musu M, Finco G (2015) Prolonged Severe Anemia and Transfusion Refusal Following Abdominal Surgery. (omicsonline.org)
History of blood transfusion2
Impact of erythrocyte transfusion2
- 1 use population-based administrative healthcare databases to estimate the impact of erythrocyte transfusion on postoperative outcomes after elective hip or knee replacement surgeries. (asahq.org)
- They demonstrate that there is a major discrepancy in the estimation of the impact of erythrocyte transfusion according to the approach used to analyze the data. (asahq.org)
- The most sensitive endpoint following oral exposure to cobalt in humans appears to be an increase in erythrocyte numbers (polycythemia). (cdc.gov)
- Blood transfusion was found to be an independent and significant risk factor for cancer progression in both models, causing up to a fourfold increase in lung tumor retention and doubling mortality rates. (nih.gov)
- in contrast, using an alternative approach based on characteristics of the centers studied, erythrocyte transfusion was found to have no impact on mortality. (asahq.org)
- In this already critical situation, it is important to remember that transfusion reactions themselves carry their own morbidity and mortality risk. (blogspot.com)
- The SNAP distinguished those infants who were given transfusions from those who did not receive transfusions, even after adjusting for phlebotomy blood loss. (elsevier.com)
- Nonetheless, observational studies comparing patients who did or did not receive transfusions may yield biased results if there are prognostically important unmeasured differences between treated and untreated patients, because multivariable regression and propensity score methods that are generally used to risk-adjust for between-group differences cannot account for unmeasured confounders. (asahq.org)
- Red blood cell (RBC) transfusions are an integral part of neonatal intensive care medicine. (bmj.com)
- 1 We recently reported that 14% of patients admitted to the Intermountain Healthcare neonatal intensive care units (NICUs) receive one or more RBC transfusions and that the average transfused neonate receives 2.4 RBC transfusions during their stay in the NICU. (bmj.com)
- Objective: To test the hypothesis that utilization of a previously described measure of acuity (ie, the score for neonatal acute physiology [SNAP]) during the first 7 postnatal days predicts which infants with a birth weight of 1500 g or less received erythrocyte transfusions during the initial hospitalization. (elsevier.com)
- We investigated the iron status of very low birth weight infants receiving multiple erythrocyte transfusions during hospitalization in the neonatal intensive care unit (NICU). (bvsalud.org)
- Exchange Transfusion in the Treatment of Neonatal Septic Shock: A Ten-Year Experience in a Neonatal Intensive Care Unit. (harvard.edu)
- Technical issues in neonatal transfusions. (harvard.edu)
Effect of the transfusion1
- In cancer patients, allogeneic blood transfusion is associated with poorer prognosis, but the independent effect of the transfusion is controversial. (nih.gov)
Acute lung i3
- CONCLUSIONS: Transfusion of erythrocytes to patients with acute lung injury had no effect on the development of acute kidney injury. (biomedsearch.com)
- Finally, acute lung injury (TRALI) is found in 1 in 5,000 transfusions. (blogspot.com)
- 8 Endothelial dysfunction has been implicated in transfusion-related acute lung injury, sepsis and multiple organ dysfunction. (haematologica.org)
- CONCLUSIONS: Early transfusion of PRBCs is an independent predictor of ARDS in adult trauma patients. (mendeley.com)
- Conclusions: In elderly anaemic MDS patients, an increment in haemoglobin is associated with improved QoL, whether induced by growth factor treatment or transfusion therapy. (diva-portal.org)
- Transfusion medicine (Oxford, England). (ethicshare.org)
- Blood transfusion is of huge importance in medicine, especially in emergency or life threatening situations. (hubpages.com)
- This cutting-edge resource covers all the important clinical aspects of transfusion medicine in diverse clinical settings, with a special emphasis on alternatives to transfusion. (ecampus.com)
- Professor Alice Maniatis , Haematology Department of Internal Medicine, University of Greece, Athens, Greece and former President of Network for Advancement of Transfusion Alternatives (NATA). (ecampus.com)
- Section 1: History and Development of Transfusion Medicine. (ecampus.com)
- 1 From blood transfusion to transfusion medicine ( Alice Maniatis ). (ecampus.com)
- Until recently the only biomedical use of erythrocytes was in transfusion medicine to restore a normal oxygen delivery. (waterstones.com)
- Manuscript Title: 'Critical Value Reporting in Transfusion Medicine: A Survey of U.S. Facilities' Communication Practices. (aabb.org)
- When a transfusion is administered to a newborn infant, the intravenous tubing through which the donor cells are infused is temporarily dedicated to this sole purpose. (bmj.com)
- The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor. (sickkids.ca)
- In developing countries the donor is sometimes specifically recruited by or for the recipient, typically a family member, and the donation occurs immediately before the transfusion. (wikipedia.org)
- The present study aimed to investigate the frequency of positive DEA 1 blood group in blood donor dogs from a blood bank in Salvador, Bahia, Brazil , and also to calculate the risk of managing incompatible blood in both first and second transfusion. (bvsalud.org)
- In conclusion, the frequency of the DEA 1 group varied between the studied breeds and the risk of incompatible blood transfusions varies according to donor and recipiente breeds, but this can be overridden if blood typing tests are performed along with the cross-reaction test for compatibility. (bvsalud.org)
- 2-4 Furthermore, some randomized controlled trials suggest that a restrictive strategy of erythrocyte transfusion is at least as effective as, and possibly superior to, a liberal transfusion strategy in critically ill patients. (asahq.org)
- Erythrocyte transfusion was implemented according to a restrictive transfusion trigger strategy. (asahq.org)
- A preoperative bolus of tranexamic acid, associated with a restrictive transfusion trigger strategy, resulted in low erythrocyte transfusion rates in patients undergoing hip arthroplasty. (asahq.org)
- In addition, a restrictive transfusion strategy will reduce exposure to allogeneic transfusions, result in more efficient use of red blood cells (RBCs), save blood overall, and decrease health care costs. (nih.gov)
- Survival over 30 days in all cardiac patients in the restrictive and liberal allogeneic RBC transfusion groups. (nih.gov)
- 73] sought to examine further whether a restrictive transfusion strategy was at least as effective as a liberal strategy in critically ill patients with cardiac disease. (nih.gov)
- Nonhemolytic fever occurs in 1 in 200 RBC recipients, but can occur in up to 20-30% of platelet transfusions. (blogspot.com)
- On transfusion, blood products interact with blood cells and plasma components to alter platelet activation, leukocyte function and red blood cell (RBC) oxygen-carrying capacity. (haematologica.org)
- Laboratory studies show hemoglobin 6.0 g/dL (60 g/L), leukocyte count 55,000/µL (55 × 10 9 /L) with 90% lymphocytes, platelet count 115,000/µL (115 × 10 9 /L), reticulocyte count 12% of erythrocytes, total bilirubin 2.8 mg/dL (47.9 µmol/L), direct bilirubin 0.6 mg/dL (10.26 µmol/L), direct antiglobulin (Coombs test) positive for IgG, ABO/Rh blood type A positive. (acphospitalist.org)
- 38% of transfused patients had a rise in creatinine the day after transfusion compared with 33% of their nontransfused matches (P = 0.315). (biomedsearch.com)
- Intraoperative blood transfusion in pediatric patients undergoing renal transplant-Effect of renal graft size. (sickkids.ca)
- 5 However, some studies provide contrasting results suggesting that transfusion might not be as deleterious in critically ill patients. (asahq.org)
- Indeed, the need for erythrocyte transfusion remains a daily clinical question for most anesthesiologists, because the optimal strategy for managing patients with low hemoglobin is not well established. (asahq.org)
- BACKGROUND: Transfusion of packed red blood cells (PRBCs) is a risk factor for acute respiratory distress syndrome (ARDS) in trauma patients. (mendeley.com)
- RESULTS: A total of 521 (4.6%) of 14070 patients developed ARDS, and 331 patients (63.5%) who developed ARDS received PRBCs transfusion. (mendeley.com)
- Conservative transfusion strategies that decrease PRBC exposure by even 1 unit may be warranted to reduce the risk of ARDS in injured patients. (mendeley.com)
- The dog erythrocyte antigen 1 (DEA 1) is the most immunogenic blood group in dogs , and blood transfusions may trigger some undesirable effects in veterinary patients , which are directly associated with incompatible transfusions. (bvsalud.org)
- A prospective study was therefore undertaken to assess patterns of blood transfusion and allo-immunisation among SCD patients in Benin City, Nigeria. (journaljammr.com)
- Antioxidant defense status was investigated in HIV-infected patients by measuring serum selenium, erythrocyte glutathione peroxidase (GSH-Px) activity, plasma thiol (-SH) and glutathione (GSH) concentrations along with the assessment of the clinical stage and surrogate markers of HIV-disease. (nature.com)
- Within 6 weeks postsurgery, three patients in each group (3.6%) underwent erythrocyte transfusion and two patients in the bolus group experienced distal deep-vein thrombosis. (asahq.org)
- 8 g/dL * Patients may receive erythrocyte transfusions to achieve this hemoglobin level at the discretion of the investigator. (cancer.gov)
- Granulocyte transfusions are indicated to protect neutropenic patients from infections. (hubpages.com)
- Meeting the needs of patients while minimizing blood transfusions requires special expertise, precise monitoring and innovative techniques. (ecampus.com)
- However, many patients seldom need whole blood transfusion. (alliedacademies.org)
- The purpose of this study was to determine the effects of aerobic exercise on erythrocyte indices in cancer patients after autologous hematopoietic stem cell transplantation. (sid.ir)
- In this study we investigated how splenectomy affects complement regulatory proteins on erythrocytes in β-TM patients. (termedia.pl)
- These patients were seen during their routine follow-up visits at the outpatients clinic and a detailed history was taken from all patients regarding age, time of the first blood transfusion, time of the last transfusion, frequency of transfusions and other information that concern the patient's status. (termedia.pl)
- β-TM patients received blood transfusion according to their blood counts (patients without splenectomy: 1-2 weeks, patients with splenectomy: 3-4 weeks intervals). (termedia.pl)
- In fact, the search for a universal threshold for hemoglobin level requiring erythrocyte transfusion is probably not the most accurate way to predict the need for transfusion. (asahq.org)
- Blood transfusions use as sources of blood either one's own ( autologous transfusion), or someone else's ( allogeneic or homologous transfusion). (wikipedia.org)
- Early transfusions used whole blood , but modern medical practice commonly uses only components of the blood, such as red blood cells , white blood cells , plasma , clotting factors , and platelets . (wikipedia.org)
- Anti-HCV was associated with elevated serum ALT levels (P = 0.0001) and with red cells (P = 0.045), but not with platelets and plasma transfusions. (elsevier.com)
- Mongan PD , Moon-Massat PF, Rentko V, Mihok S, Dragovich A, Sharma P. Regional blood flow after serial normovolemic exchange transfusion with HBOC-201 (Hemopure) in anesthetized swine. (mayoclinic.org)
- Exchange Transfusion, Whole Blood" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- This graph shows the total number of publications written about "Exchange Transfusion, Whole Blood" by people in Harvard Catalyst Profiles by year, and whether "Exchange Transfusion, Whole Blood" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Exchange Transfusion, Whole Blood" by people in Profiles. (harvard.edu)
- American society for apheresis guidelines support use of red cell exchange transfusion for severe malaria with high parasitemia. (harvard.edu)
- Blood typing is a screening test to determine blood groups and Rh antigen for blood transfusion and pregnancy. (findacode.com)
- If some rare clinical hazards manifest as acute inflammation symptoms of various origin, most of them linked with conflicting and undesirable biological material accompanying the therapeutic component (infectious pathogen, pathogenic antibody, unwanted antigen, or allergen), the general feature is subtler and less visible, and essentially consists of alloimmunization or febrile non-hemolytic transfusion reaction. (frontiersin.org)
- In its earliest days, transfusion was clearly associated with acute inflammation, though the connection was not acknowledged as such: indeed, the very first reported serious adverse events (SAEs) of "modern" transfusion in the early twentieth century were dual in nature: first, immune-hematological [i.e., antigen-antibody (ABO)] conflicts, and second, blood-borne and blood-transmitted infections, such as syphilis and malaria ( 2 ). (frontiersin.org)
- the number of units ordered for any given patient may need to be modified in the light of the patient's preoperative condition, coagulation status, and clinically significant antibodies that may make finding compatible erythrocytes difficult. (asahq.org)
- Flow cytometric determinations of CD34+ cells were performed from 20 cord blood samples, using three different erythrocyte lysing procedures and two monoclonal CD34 antibodies (n = 360). (deepdyve.com)
- In contrast, the determination of CD34+ cells by two CD34 antibodies showed a good reproducibility without significant differences between both antibodies for each of the erythrocyte lysing techniques. (deepdyve.com)
- Four (7.3%) of the subjects had unexpected erythrocyte allo-antibodies. (journaljammr.com)
- Thus, researchers in this field have an extraordinary opportunity to specifically modify the erythrocytes by the introduction of enzymes that generate new metabolic abilities, antibodies that inactivate single metabolic steps, or metabolites that can influence oxygen delivery and/or other cell properties. (waterstones.com)
- Design and Methods The repertoire of adhesive molecules on mouse erythrocytes and bEnd.3 microvascular endothelial cells was determined by flow cytometry using monoclonal antibodies or by Western blot. (haematologica.org)
- Based on literature analysis using database search engines PubMed, Google Scholar, Ovid in field of erythrocyte antibodies, laboratory diagnostics and clinical importance up-to-date knowledge. (prolekare.cz)
- Erythrocyte alloimunization anti-D antibodies decreases in connection with the introduction of immunoprofylaxis. (prolekare.cz)
- These antibodies are used to prevent sensitization by catching erythrocytes that reach the mother's bloodstream from the fetal bloodstream already before birth. (news-medical.net)
- Main Outcome Measures: Occurrence or nonoccurrence of erythrocyte transfusion was determined in 47 infants who were compared for demographic information, phlebotomy blood loss, diagnoses, medications, and the SNAP at 0, 1, 2, and 7 days of life. (elsevier.com)
- Results: Infants with a birth weight of 1500 g or less received a mean±SD of 1.9±2.9 transfusions, with 22 (47%) of the infants given transfusions. (elsevier.com)
- The logistic model predicted which infants had been administered transfusions with 86% sensitivity and 88% specificity. (elsevier.com)
- A total of 38 (82.6%) of very low birth weight infants received a mean volume of 99.3+/-93.5 mL of erythrocyte transfusions in NICU. (bvsalud.org)
- Very low birth weight infants undergoing multiply erythrocyte transfusions had excessive iron stores and non-transfused infants also might had a risk of iron overload during hospitalization in the NICU. (bvsalud.org)
- Red blood cell transfusions (RBCTs) are often given to very low birthweight infants, and 50-80% of these infants receive multiple RBCTs during their initial hospital stay. (bmj.com)
- This study investigated the potential role of of nitric oxide (NO) treatment of stored red blood cells (RBCs) before transfusion in a stable haemodynamic and non-inflammatory animal model. (nataonline.com)
- The authors show that pretreatment of older stored RBCs (>40 days) with NO can limit the increase in mean pulmonary arterial pressure (PAPm) observed after transfusion. (nataonline.com)
- Interestingly, although little discussed in the article, limitation of the increase in PAPm was also obtained after transfusion of fresh RBCs (2 days of storage) without NO. This study adds to current knowlegde on the potential effects of RBC storage. (nataonline.com)
- Laboratories with expertise in RBC function, nitric oxide mechanisms, the coagulation cascade, microparticle analysis and immunology will each examine hypotheses addressing mechanisms potentially able to relate storage time to clinical outcomes in RBC transfusion recipients. (clinicaltrials.gov)
- 3 Current Information on the Infectious Risks of Allogeneic Blood Transfusion (A. Kitchen and J. Barbara). (ecampus.com)
- 5 Immunomodulation and Allogeneic Transfusion ( M. Waanders, L. van de Watering, A. Brand ). (ecampus.com)
- 7 The Benefits of Allogeneic Erythrocyte Transfusion: What Evidence Do We Have? (ecampus.com)
- In other patient populations, erythrocyte transfusion has been associated with increased risk of adverse outcomes including sepsis, multisystem organ dysfunction, and death. (biomedsearch.com)
- It has been observed that erythrocyte transfusion is associated with worse outcomes in most of the observational studies. (asahq.org)
- 1 There is, however, ongoing concern that transfusions may worsen outcomes. (asahq.org)
- Sheelagh is the Head of Student Experience and Academic Outcomes and also serves as a principal lecturer in Clinical Biochemistry, Haematology and Transfusion Science. (londonmet.ac.uk)
- Consequently, observational studies may overestimate risks attributable to transfusions. (asahq.org)
- In this clinical commentary, key points related to pretransfusion testing are reviewed with an emphasis on the electronic crossmatch, as well as the use of uncrossmatched erythrocytes in situations where crossmatch-compatible units are not yet available for transfusion. (asahq.org)
- Sibrowski, 1998-06-01 00:00:00 Since the correct determination of CD34+ cells is of great clinical importance for successful transplantation with haematopoietic progenitor cells (HPCs) from cord blood, we investigated the influence of different erythrocyte lysing techniques on the quantification of CD34+ cells in umbilical cord blood. (deepdyve.com)
- The aim of this review is to give comprehensive summary of erythrocyte alloimunization of pregnant women, laboratory dignostics and clinical importance. (prolekare.cz)
- For example, photons or radicals can induce hemolysis.Erythrocytes/RBC may also be tested for related membrane properties aside from fragility, including erythrocyte deformability and cell morphology. (wikipedia.org)
- Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration. (hopkinsmedicine.org)
- Cluster of erythrocyte band 3: a potential molecular target of exhaustive exercise-induced dysfunction of erythrocyte deformability. (semanticscholar.org)
- Erythrocyte transfusions in neonates: is it safe to co-infuse dextrose-containing solutions? (bmj.com)
- This leads to a major discrepancy not only between transfusion strategies used between centers but also between anesthesiologists. (asahq.org)
- Transfusion of whole blood is currently being practiced in many centers in Nigeria despite the sustained short supply from voluntary donation. (alliedacademies.org)
- Furthermore, transfusion services involving blood compo nents are not readily available in many centers, thereby limiting service providers to storage and transfusion of whole blood. (alliedacademies.org)
- p -(chloromercuri)benzenesulfonate binding by membrane proteins and the inhibition of water transport in human erythrocytes. (springer.com)
- Identification, purification, and partial characterization of a novel M r 28,000 integral membrane protein from erythrocytes and renal tubules. (springer.com)
- Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. (springer.com)
- Without a nucleus, a mature erythrocyte (or RBC) contains a cytosol enclosed within a highly flexible cell membrane. (frontiersin.org)
- We here report on the usefulness of the D4 fragment of Clostridium perfringens toxin fused to mCherry (theta*), as specific, non-toxic, sensitive and quantitative cholesterol-labeling tool, using erythrocyte flat membrane. (springer.com)
- Cholesterol domains on spread erythrocytes are stable in time and space, restricted by membrane:spectrin anchorage via 4.1R complexes, and depend on temperature and sphingomyelin, indicating combined regulation by extrinsic membrane:cytoskeleton interaction and by intrinsic lipid packing. (springer.com)
- Membrane markers profiling: Comparative analysis of microvesicles derived from erythrocyte and HeLa cells infected with Human Rhinovirus type 16. (londonmet.ac.uk)
- Contribution of the band 3-ankyrin interaction to erythrocyte membrane mechanical stability. (semanticscholar.org)
- For this purpose erythrocytes were equilibrated overnight in nutrient-containing buffers at a range of elevated pHs and then examined for changes in mechanical stability and membrane skeletal composition. (semanticscholar.org)
- Regulation of membrane-cytoskeletal interactions by tyrosine phosphorylation of erythrocyte band 3. (semanticscholar.org)
- Isolation and characterization of the hemichrome-stabilized membrane protein aggregates from sickle erythrocytes. (semanticscholar.org)
- CD55 and CD59, which are glycosylphosphatidylinositol anchored, inhibit formation of the C3 convertases and prevent the terminal polymerization of the membrane attack complex on the cell surface of erythrocytes. (termedia.pl)
- Exposure of stored packed erythrocytes to nitric oxide prevents transfusion-associated pulmonary hypertension. (nataonline.com)
- Blood transfusion remains a mainstay therapy in sickle cell disease (SCD).Transfusional therapy may be complicated by allo-immunisation due to exposure to foreign red cell antigens. (journaljammr.com)
- Erythrocyte alloimmunisation is a significant therapy related complication in Nigerian SCD. (journaljammr.com)
- He has not received specific therapy and has never required a blood transfusion. (acphospitalist.org)
- Corticosteroid therapy is begun, and a cross-match for two units of packed erythrocytes is ordered. (acphospitalist.org)
- This book, The Use of Resealed Erythrocytes, is based on the fourth meeting of the "International Society for the Use of Resealed Erythrocytes as Carriers and Bioreactors" (I. S. U. R. E. ), held in Urbino, Italy, in 1991, and examines the most recent applications and developments of this technology. (waterstones.com)
- Erythrocyte fragility refers to the propensity of erythrocytes (red blood cells, RBC) to hemolyse (rupture) under stress. (wikipedia.org)
- Uses of erythrocyte mechanical fragility can include diagnostic testing, calibrations to aid comparisons of hemolysis caused by blood-handling devices, or assessment of sublethal (i.e., non-hemolysing) damage caused to cells from devices that manipulate blood (such as for dialysis or intraoperative autotransfusion). (wikipedia.org)
- 3. Goodnough, LT: Risks of Blood Transfusion. (blogspot.com)
- Currently, a number of teams have shown that engineered erythrocytes can behave as circulating bioreactors for the degradation of toxic metabolites or the inactivation of xenobiotics, as drug delivery systems, as carriers of antigens of vaccinal interest, and in many others biomedical applications. (waterstones.com)
- Blood groups are characterized by erythrocyte (red blood cell) antigens with common immunologic properties (eg, group A). Blood group systems are series of such antigens encoded by a single gene or by a cluster of 2 or 3 closely linked homologous genes (eg, ABO system). (amamanualofstyle.com)
- There are about 600 recognized erythrocyte antigens. (amamanualofstyle.com)
- The International Society of Blood Transfusion (ISBT) designates around 270 blood group antigens. (amamanualofstyle.com)
- White blood cells are not commonly used during transfusion, but are part of the immune system, and fight infections. (wikipedia.org)
- Packed red blood cells (pRBC) are red blood cells that have been donated, processed, and stored in a blood bank for blood transfusion. (wikipedia.org)
- Erythrocyte growth factors are drugs that help the body make more red blood cells. (cancer.ca)
- The stages of differentiation of the red line starts from multipotent stem cells (also called hemocytoblasts), goes through common multipotent myeloid progenitors, unipotent stem cells, proerythroblasts (also called pronormoblast), basophilic normoblasts (also called erythroblast-secretes erythroferrone that inhibits the hepcidin secretion), intermediate normoblast-polychromatophilic, orthochrome normoblast (the nucleus is expelled) and reticulocytes (normally accounts for 1% of blood cells and lasts for 1-2 days until maturation to erythrocytes). (spandidos-publications.com)
- The average lifespan of an erythrocyte is 120 days and, every day, 200 billion red blood cells are released into circulation and 'withdrawn' respectively ( 1 ). (spandidos-publications.com)
- 45% Red blood cells or erythrocytes » 5.5 million red cells in men and » 4.7 million in women, but there is a considerable normal variation in these values. (issuu.com)
- Kasturi Haldar and col leagues from Northwestern University Medical School, Chicago, investigated a protein in red blood cells (erythrocyte guanine nucleotide regulatory protein Gs) as a novel antimalarial target. (brightsurf.com)
- The rhesus factor is an inherited characteristic of the red blood cells (erythrocytes). (news-medical.net)
- We collected individual data of the frequency and volume of erythrocyte transfusion and the amount of iron intake. (bvsalud.org)
- Edited by a multidisciplinary team consisting of a transfusion specialist, an anesthesiologist and an intensive care specialist this book is endorsed by the Network for Advancement of Transfusion Alternatives. (ecampus.com)
- Patient refusal to receive blood transfusion was respected throughout general anaesthesia and subsequent intensive care unit and ward stay. (omicsonline.org)
- use of erythrocyte transfusions or erythropoiesis-enhancing drugs to improve athletic performance. (thefreedictionary.com)