Erythrocytes
Hematocrit
Blood Cell Count
Hemoglobins
Erythrocyte Membrane
Leukocyte Count
Erythrocyte Aging
Erythrocyte Deformability
Anion Exchange Protein 1, Erythrocyte
Hemolysis
CD4 Lymphocyte Count
Erythrocyte Aggregation
Terminology as Topic
Clinical Laboratory Information Systems
Encyclopedias as Topic
Electronic Health Records
Vocabulary, Controlled
Systematized Nomenclature of Medicine
No-Observed-Adverse-Effect Level
Toxicity Tests, Acute
Fatty Alcohols
Lanolin
Social Isolation
Salivation
Infleuce of dietary levels of vitamin E and selenium on tissue and blood parameters in pigs. (1/796)
Eighteen barrows approximately three weeks of age were used in a 3 X 3 factorial arrangement to investigate the effect of level of supplemental vitamin E and selenium on tissue and blood parameters. Tissue selenium concentrations increased in a quadratic manner with increased selenium intake with kidney tissue containing considerably greater concentrations than liver, heart or muscle. Supplementation of the diet caused a three-fold increase in serum selenium within the first week with a slight tendency to further increases in subsequent weeks. Serum vitamin E of unsupplemented pigs declined by fifty percent during the experiment, whereas supplemental vitamin E resulted in increased serum vitamin E. There was a considerable viration in percent peroxide hemolysis. Correlation of -0.63 between percent peroxide hemolysis and vitamin E intake and -0.85 between percent peroxide hemolysis and serum vitamin E were observed. (+info)Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. (2/796)
High levels of fetal hemoglobin (Hb F) protect from many of the complications of sickle cell disease and lead to improved survival. Butyrate and other short chain fatty acids were previously shown to increase Hb F production in erythroid cells in vitro and in animal models in vivo. However, butyrates are also known to inhibit the proliferation of many cell types, including erythroid cells. Experience with the use of butyrate in animal models and in early clinical trials demonstrated that the Hb F response may be lost after prolonged administration of high doses of butyrate. We hypothesized that this loss of response may be a result of the antiproliferative effects of butyrate. We designed a regimen consisting of intermittent or pulse therapy in which butyrate was administered for 4 days followed by 10 to 24 days with no drug exposure. This pulse regimen induced fetal globin gene expression in 9 of 11 patients. The mean Hb F in this group increased from 7.2% to 21.0% (P <.002) after intermittent butyrate therapy for a mean duration of 29.9 weeks. This was associated with a parallel increase in the number of F cells and F reticulocytes. The total hemoglobin levels also increased from a mean of 7.8 g/dL to a mean of 8.8 g/dL (P <.006). The increased levels of Hb F were sustained in all responders, including 1 patient who has been on pulse butyrate therapy for more than 28 months. This regimen, which resulted in a marked and sustained increase in Hb F levels in more than two thirds of the adult sickle cell patients enrolled in this study, was well tolerated without adverse side effects. These encouraging results require confirmation along with an appropriate evaluation of clinical outcomes in a larger number of patients with sickle cell disease. (+info)Neutrophil activation and hemostatic changes in healthy donors receiving granulocyte colony-stimulating factor. (3/796)
Granulocyte colony-stimulating factor (G-CSF) enhances neutrophil functions in vitro and in vivo. It is known that neutrophil-derived products can alter the hemostatic balance. To understand whether polymorphonuclear leukocyte (PMN) activation, measured as PMN degranulation and phenotypical change, may be associated to hemostatic alterations in vivo, we have studied the effect of recombinant human G-CSF (rHuG-CSF) administration on leukocyte parameters and hemostatic variables in healthy donors of hematopoietic progenitor cells (HPCs). Twenty-six consecutive healthy donors receiving 10 micrograms/kg/d rHuG-CSF subcutaneously for 5 to 7 days to mobilize HPCs for allogeneic transplants were included in the study. All of them responded to rHuG-CSF with a significant white blood cell count increase. Blood samples were drawn before therapy on days 2 and 5 and 1 week after stopping rHuG-CSF treatment. The following parameters were evaluated: (1) PMN activation parameters, ie, surface CD11b/CD18 antigen expression, plasma elastase antigen levels and cellular elastase activity; (2) plasma markers of endothelium activation, ie, thrombomodulin (TM) and von Willebrand factor (vWF) antigens; (3) plasma markers of blood coagulation activation, ie, F1+2, TAT complex, D-dimer; and (4) mononuclear cell (MNC) procoagulant activity (PCA) expression. The results show that, after starting rHuG-CSF, an in vivo PMN activation occurred, as demonstrated by the significant increment of surface CD11b/CD18 and plasma elastase antigen levels. Moreover, PMN cellular elastase activity, which was significantly increased at 1 day of treatment, returned to baseline at day 5 to 6, in correspondence with the elastase antigen peak in the circulation. This change was accompanied by a parallel significant increase in plasma levels of the two endothelial and the three coagulation markers. The PCA generated in vitro by unstimulated MNC isolated from rHuG-CSF-treated subjects was not different from that of control cells from untreated subjects. However, endotoxin-stimulated MNC isolated from on-treatment individuals produced significantly more PCA compared with both baseline and control samples. All of the parameters were decreased or normal 1 week after stopping treatment. These data show that rHuG-CSF induces PMN activation and transiently affects some hemostatic variables in healthy HPC donor subjects. The clinical significance of these findings remains to be established. (+info)Betamethasone-mediated vascular dysfunction and changes in hematological profile in the ovine fetus. (4/796)
Glucocorticoid administration to fetal sheep induces a sustained systemic blood pressure rise and an associated increase in femoral vascular resistance. We utilized a small vessel myograph to compare isometric vascular responses of small femoral arterial branches from fetal sheep infused intravenously with either betamethasone or vehicle in vivo from 128 days gestation. Changes in hematological parameters were also determined. Betamethasone was infused for 48 h to produce fetal plasma betamethasone concentrations similar to those observed in human fetuses after maternal treatment with betamethasone to accelerate fetal lung maturation. When compared with vessels removed from vehicle-infused fetuses, vessels obtained from betamethasone-treated fetuses exhibited 1) enhanced sensitivity to depolarizing potassium solutions; 2) no differences in response to the thromboxane mimetic U-46619 or norepinephrine; and 3) differential responses to vasodilators, enhanced sensitivity to ACh, but decreased response to bradykinin and forskolin. In addition, erythrocyte and leukocyte counts were increased in betamethasone-infused fetuses. These observations indicate that multiple mechanisms operate to increase fetal vascular resistance during antenatal betamethasone exposure. (+info)Prevention of transfusion-associated graft-versus-host disease by photochemical treatment. (5/796)
Photochemical treatment (PCT) with the psoralen S-59 and long wavelength ultraviolet light (UVA) inactivates high titers of contaminating viruses, bacteria, and leukocytes in human platelet concentrates. The present study evaluated the efficacy of PCT to prevent transfusion-associated graft-versus-host disease (TA-GVHD) in vivo using a well-characterized parent to F1 murine transfusion model. Recipient mice in four treatment groups were transfused with 10(8) splenic leukocytes. (1) Control group mice received syngeneic splenic leukocyte transfusions; (2) GVHD group mice received untreated allogeneic splenic leukocytes; (3) gamma radiation group mice received gamma irradiated (2,500 cGy) allogeneic splenic leukocytes; and (4) PCT group mice received allogeneic splenic leukocytes treated with 150 micromol/L S-59 and 2.1 J/cm2 UVA. Multiple biological and clinical parameters were used to monitor the development of TA-GVHD in recipient mice over a 10-week posttransfusion observation period: peripheral blood cell levels, spleen size, engraftment by donor T cells, thymic cellularity, clinical signs of TA-GVHD (weight loss, activity, posture, fur texture, skin integrity), and histologic lesions of liver, spleen, bone marrow, and skin. Mice in the control group remained healthy and free of detectable disease. Mice in the GVHD group developed clinical and histological lesions of TA-GVHD, including pancytopenia, marked splenomegaly, wasting, engraftment with donor derived T cells, and thymic hypoplasia. In contrast, mice transfused with splenic leukocytes treated with (2,500 cGy) gamma radiation or 150 micromol/L S-59 and 2.1 J/cm2 UVA remained healthy and did not develop detectable TA-GVHD. Using an in vitro T-cell proliferation assay, greater than 10(5.1) murine T cells were inactivated by PCT. Therefore, in addition to inactivating high levels of pathogenic viruses and bacteria in PC, these data indicate that PCT is an effective alternative to gamma irradiation for prevention of TA-GVHD. (+info)Immunohematological reference ranges for adult Ethiopians. (6/796)
A cross-sectional survey was carried out with 485 healthy working adult Ethiopians who are participating in a cohort study on the progression of human immunodeficiency virus type 1 (HIV-1) infection to establish hematological reference ranges for adult HIV-negative Ethiopians. In addition, enumeration of absolute numbers and percentages of leukocyte subsets was performed for 142 randomly selected HIV-negative individuals. Immunological results were compared to those of 1,356 healthy HIV-negative Dutch blood donor controls. Immunohematological mean values, medians, and 95th percentile reference ranges were established. Mean values were as follows: leukocyte (WBC) counts, 6.1 x 10(9)/liter (both genders); erythrocyte counts, 5.1 x 10(12)/liter (males) and 4.5 x 10(12)/liter (females); hemoglobin, 16.1 (male) and 14.3 (female) g/dl; hematocrit, 48.3% (male) and 42.0% (female); platelets, 205 x 10(9)/liter (both genders); monocytes, 343/microl; granulocytes, 3, 057/microl; lymphocytes, 1,857/microl; CD4 T cells, 775/microl; CD8 T cells, 747/microl; CD4/CD8 T-cell ratio, 1.2; T cells, 1, 555/microl; B cells, 191/microl; and NK cells, 250/microl. The major conclusions follow. (i) The WBC and platelet values of healthy HIV-negative Ethiopians are lower than the adopted reference values of Ethiopia. (ii) The absolute CD4 T-cell counts of healthy HIV-negative Ethiopians are considerably lower than those of the Dutch controls, while the opposite is true for the absolute CD8 T-cell counts. This results in a significantly reduced CD4/CD8 T-cell ratio for healthy Ethiopians, compared to the ratio for Dutch controls. (+info)Oxidative modification of lipids and proteins in aniline-induced splenic toxicity. (7/796)
Our earlier studies with aniline suggested the involvement of oxidative stress as an early toxic event in the spleen. In order to understand the status and consequences of the damaging oxidative reactions, especially during the progression of characteristic splenic lesions, time-dependent subchronic studies were conducted in rats. Male Sprague-Dawley rats were treated with 65 mg/kg/day aniline in the drinking water, while control rats received drinking water only. The animals were euthanized after 1, 2, or 3 months of aniline exposure. Total iron content was remarkably greater in the aniline-treated rats than in age-matched controls. There were time-dependent increases in splenic lipid peroxidation of aniline-treated rats. Malondialdehyde-protein adducts were quantitated by a competitive ELISA and showed greater concentrations in the spleens of aniline-treated rats, further substantiating our lipid peroxidation results. Protein oxidation in the spleens of aniline-treated rats was also greater, with a maximum increase of approximately 76% at 3 months. Western blot analysis for oxidized proteins showed two distinct protein bands at approximately 114 kD and approximately 69 kD in both post-nuclear and mitochondrial fractions of the spleens. Furthermore, densitometric analysis of the blot showed increased band intensities of the oxidized proteins in both these spleen fractions from aniline-treated rats, suggesting the susceptibility of these proteins to aniline-induced oxidative stress. The most prominent morphological changes in the spleens of aniline-treated rats included thickening of the capsule, and capsular cells with nuclear prominence and hyperchromia indicative of capsular hyperplasia. These capsular changes and fibrosis of capsule, splenic trabeculae, and red pulp were noted at all three time points after aniline exposure. Our studies thus suggest that aniline-induced oxidative stress in the spleen is an ongoing event that leads to oxidative modifications of biomolecules. Such oxidative modifications, directly or indirectly, could contribute to the splenic toxicity leading to deleterious consequences, including capsular hyperplasia and fibrosis, as observed in this study, and possibly tumorigenesis in chronic aniline exposure conditions. (+info)Selection for high and low virulence in the malaria parasite Plasmodium chabaudi. (8/796)
What stops parasites becoming ever more virulent? Conventional wisdom and most parasite-centred models of the evolution of virulence suppose that risk of host (and, hence, parasite) death imposes selection against more virulent strains. Here we selected for high and low virulence within each of two clones of the rodent malaria parasite Plasmodium chabaudi on the basis of between-host differences in a surrogate measure of virulence--loss of live weight post-infection. Despite imposing strong selection for low virulence which mimicked 50-75% host mortality, the low virulence lines increased in virulence as much as the high virulence lines. Thus, artificial selection on between-host differences in virulence was unable to counteract natural selection for increased virulence caused by within-host selection processes. The parasite's asexual replication rate and number of sexual transmission forms also increased in all lines, consistent with evolutionary models explaining high virulence. An upper bound to virulence, though not the asexual replication rate, was apparent, but this bound was not imposed by host mortality. Thus, we found evidence of the factors assumed to drive evolution of increased virulence, but not those thought to counter this selection. (+info)Erythrocyte count, also known as red blood cell (RBC) count, is a laboratory test that measures the number of red blood cells in a sample of blood. Red blood cells are important because they carry oxygen from the lungs to the rest of the body. A low erythrocyte count may indicate anemia, while a high count may be a sign of certain medical conditions such as polycythemia. The normal range for erythrocyte count varies depending on a person's age, sex, and other factors.
Erythrocytes, also known as red blood cells (RBCs), are the most common type of blood cell in circulating blood in mammals. They are responsible for transporting oxygen from the lungs to the body's tissues and carbon dioxide from the tissues to the lungs.
Erythrocytes are formed in the bone marrow and have a biconcave shape, which allows them to fold and bend easily as they pass through narrow blood vessels. They do not have a nucleus or mitochondria, which makes them more flexible but also limits their ability to reproduce or repair themselves.
In humans, erythrocytes are typically disc-shaped and measure about 7 micrometers in diameter. They contain the protein hemoglobin, which binds to oxygen and gives blood its red color. The lifespan of an erythrocyte is approximately 120 days, after which it is broken down in the liver and spleen.
Abnormalities in erythrocyte count or function can lead to various medical conditions, such as anemia, polycythemia, and sickle cell disease.
Hematocrit is a medical term that refers to the percentage of total blood volume that is made up of red blood cells. It is typically measured as part of a complete blood count (CBC) test. A high hematocrit may indicate conditions such as dehydration, polycythemia, or living at high altitudes, while a low hematocrit may be a sign of anemia, bleeding, or overhydration. It is important to note that hematocrit values can vary depending on factors such as age, gender, and pregnancy status.
Hematologic tests, also known as hematology tests, are a group of diagnostic exams that evaluate the health and function of different components of blood, such as red and white blood cells, platelets, and clotting factors. These tests can detect various disorders, including anemia, infection, bleeding problems, and several types of cancer. Common hematologic tests include complete blood count (CBC), coagulation studies, peripheral smear examination, and erythrocyte sedimentation rate (ESR). The specific test or combination of tests ordered will depend on the patient's symptoms, medical history, and physical examination findings.
A "Blood Cell Count" is a medical laboratory test that measures the number of red blood cells (RBCs), white blood cells (WBCs), and platelets in a sample of blood. This test is often used as a part of a routine check-up or to help diagnose various medical conditions, such as anemia, infection, inflammation, and many others.
The RBC count measures the number of oxygen-carrying cells in the blood, while the WBC count measures the number of immune cells that help fight infections. The platelet count measures the number of cells involved in clotting. Abnormal results in any of these counts may indicate an underlying medical condition and further testing may be required for diagnosis and treatment.
Hemoglobin (Hb or Hgb) is the main oxygen-carrying protein in the red blood cells, which are responsible for delivering oxygen throughout the body. It is a complex molecule made up of four globin proteins and four heme groups. Each heme group contains an iron atom that binds to one molecule of oxygen. Hemoglobin plays a crucial role in the transport of oxygen from the lungs to the body's tissues, and also helps to carry carbon dioxide back to the lungs for exhalation.
There are several types of hemoglobin present in the human body, including:
* Hemoglobin A (HbA): This is the most common type of hemoglobin, making up about 95-98% of total hemoglobin in adults. It consists of two alpha and two beta globin chains.
* Hemoglobin A2 (HbA2): This makes up about 1.5-3.5% of total hemoglobin in adults. It consists of two alpha and two delta globin chains.
* Hemoglobin F (HbF): This is the main type of hemoglobin present in fetal life, but it persists at low levels in adults. It consists of two alpha and two gamma globin chains.
* Hemoglobin S (HbS): This is an abnormal form of hemoglobin that can cause sickle cell disease when it occurs in the homozygous state (i.e., both copies of the gene are affected). It results from a single amino acid substitution in the beta globin chain.
* Hemoglobin C (HbC): This is another abnormal form of hemoglobin that can cause mild to moderate hemolytic anemia when it occurs in the homozygous state. It results from a different single amino acid substitution in the beta globin chain than HbS.
Abnormal forms of hemoglobin, such as HbS and HbC, can lead to various clinical disorders, including sickle cell disease, thalassemia, and other hemoglobinopathies.
An erythrocyte, also known as a red blood cell, is a type of cell that circulates in the blood and is responsible for transporting oxygen throughout the body. The erythrocyte membrane refers to the thin, flexible barrier that surrounds the erythrocyte and helps to maintain its shape and stability.
The erythrocyte membrane is composed of a lipid bilayer, which contains various proteins and carbohydrates. These components help to regulate the movement of molecules into and out of the erythrocyte, as well as provide structural support and protection for the cell.
The main lipids found in the erythrocyte membrane are phospholipids and cholesterol, which are arranged in a bilayer structure with the hydrophilic (water-loving) heads facing outward and the hydrophobic (water-fearing) tails facing inward. This arrangement helps to maintain the integrity of the membrane and prevent the leakage of cellular components.
The proteins found in the erythrocyte membrane include integral proteins, which span the entire width of the membrane, and peripheral proteins, which are attached to the inner or outer surface of the membrane. These proteins play a variety of roles, such as transporting molecules across the membrane, maintaining the shape of the erythrocyte, and interacting with other cells and proteins in the body.
The carbohydrates found in the erythrocyte membrane are attached to the outer surface of the membrane and help to identify the cell as part of the body's own immune system. They also play a role in cell-cell recognition and adhesion.
Overall, the erythrocyte membrane is a complex and dynamic structure that plays a critical role in maintaining the function and integrity of red blood cells.
A leukocyte count, also known as a white blood cell (WBC) count, is a laboratory test that measures the number of leukocytes in a sample of blood. Leukocytes are a vital part of the body's immune system and help fight infection and inflammation. A high or low leukocyte count may indicate an underlying medical condition, such as an infection, inflammation, or a bone marrow disorder. The normal range for a leukocyte count in adults is typically between 4,500 and 11,000 cells per microliter (mcL) of blood. However, the normal range can vary slightly depending on the laboratory and the individual's age and sex.
Erythrocyte aging, also known as red cell aging, is the natural process of changes and senescence that occur in red blood cells (erythrocytes) over time. In humans, mature erythrocytes are devoid of nuclei and organelles, and have a lifespan of approximately 120 days.
During aging, several biochemical and structural modifications take place in the erythrocyte, including:
1. Loss of membrane phospholipids and proteins, leading to increased rigidity and decreased deformability.
2. Oxidative damage to hemoglobin, resulting in the formation of methemoglobin and heinz bodies.
3. Accumulation of denatured proteins and aggregates, which can impair cellular functions.
4. Changes in the cytoskeleton, affecting the shape and stability of the erythrocyte.
5. Increased expression of surface markers, such as Band 3 and CD47, that signal the spleen to remove aged erythrocytes from circulation.
The spleen plays a crucial role in removing senescent erythrocytes by recognizing and phagocytosing those with altered membrane composition or increased expression of surface markers. This process helps maintain the overall health and functionality of the circulatory system.
Erythrocyte deformability refers to the ability of red blood cells (erythrocytes) to change shape and bend without rupturing, which is crucial for their efficient movement through narrow blood vessels. This deformability is influenced by several factors including the cell membrane structure, hemoglobin concentration, and intracellular viscosity. A decrease in erythrocyte deformability can negatively impact blood flow and oxygen delivery to tissues, potentially contributing to various pathological conditions such as sickle cell disease, diabetes, and cardiovascular diseases.
Anion Exchange Protein 1, Erythrocyte (AE1), also known as Band 3 protein or SLC4A1, is a transmembrane protein found in the membranes of red blood cells (erythrocytes). It plays a crucial role in maintaining the pH and bicarbonate levels of the blood by facilitating the exchange of chloride ions (Cl-) with bicarbonate ions (HCO3-) between the red blood cells and the plasma.
The anion exchange protein 1 is composed of three major domains: a cytoplasmic domain, a transmembrane domain, and an extracellular domain. The cytoplasmic domain interacts with various proteins involved in regulating the cytoskeleton of the red blood cell, while the transmembrane domain contains the ion exchange site. The extracellular domain is responsible for the interaction between red blood cells and contributes to their aggregation.
Mutations in the AE1 gene can lead to various inherited disorders, such as hereditary spherocytosis, Southeast Asian ovalocytosis, and distal renal tubular acidosis type 1. These conditions are characterized by abnormal red blood cell shapes, impaired kidney function, or both.
Hemolysis is the destruction or breakdown of red blood cells, resulting in the release of hemoglobin into the surrounding fluid (plasma). This process can occur due to various reasons such as chemical agents, infections, autoimmune disorders, mechanical trauma, or genetic abnormalities. Hemolysis may lead to anemia and jaundice, among other complications. It is essential to monitor hemolysis levels in patients undergoing medical treatments that might cause this condition.
A platelet count is a laboratory test that measures the number of platelets, also known as thrombocytes, in a sample of blood. Platelets are small, colorless cell fragments that circulate in the blood and play a crucial role in blood clotting. They help to stop bleeding by sticking together to form a plug at the site of an injured blood vessel.
A normal platelet count ranges from 150,000 to 450,000 platelets per microliter (µL) of blood. A lower than normal platelet count is called thrombocytopenia, while a higher than normal platelet count is known as thrombocytosis.
Abnormal platelet counts can be a sign of various medical conditions, including bleeding disorders, infections, certain medications, and some types of cancer. It is important to consult with a healthcare provider if you have any concerns about your platelet count or if you experience symptoms such as easy bruising, prolonged bleeding, or excessive menstrual flow.
A CD4 lymphocyte count is a laboratory test that measures the number of CD4 T-cells (also known as CD4+ T-cells or helper T-cells) in a sample of blood. CD4 cells are a type of white blood cell that plays a crucial role in the body's immune response, particularly in fighting off infections caused by viruses and other pathogens.
CD4 cells express a protein on their surface called the CD4 receptor, which is used by human immunodeficiency virus (HIV) to infect and destroy these cells. As a result, people with HIV infection or AIDS often have low CD4 lymphocyte counts, which can make them more susceptible to opportunistic infections and other complications.
A normal CD4 lymphocyte count ranges from 500 to 1,200 cells per cubic millimeter of blood (cells/mm3) in healthy adults. A lower than normal CD4 count is often used as a marker for the progression of HIV infection and the development of AIDS. CD4 counts are typically monitored over time to assess the effectiveness of antiretroviral therapy (ART) and to guide clinical decision-making regarding the need for additional interventions, such as prophylaxis against opportunistic infections.
Erythrocyte aggregation, also known as rouleaux formation, is the clumping together of red blood cells (erythrocytes) in a way that resembles a stack of coins. This phenomenon is typically observed under low-shear conditions, such as those found in small blood vessels and capillaries.
The aggregation of erythrocytes is influenced by several factors, including the concentration of plasma proteins, the charge and shape of the red blood cells, and the flow characteristics of the blood. One of the most important proteins involved in this process is fibrinogen, a large plasma protein that can bridge between adjacent red blood cells and cause them to stick together.
Erythrocyte aggregation can have significant effects on blood flow and rheology (the study of how blood flows), particularly in diseases such as diabetes, sickle cell disease, and certain types of anemia. Increased erythrocyte aggregation can lead to reduced oxygen delivery to tissues, increased blood viscosity, and impaired microcirculatory flow, all of which can contribute to tissue damage and organ dysfunction.
"Terminology as a topic" in the context of medical education and practice refers to the study and use of specialized language and terms within the field of medicine. This includes understanding the meaning, origins, and appropriate usage of medical terminology in order to effectively communicate among healthcare professionals and with patients. It may also involve studying the evolution and cultural significance of medical terminology. The importance of "terminology as a topic" lies in promoting clear and accurate communication, which is essential for providing safe and effective patient care.
A Clinical Laboratory Information System (CLIS) is a type of healthcare information system that is designed to automate and manage the workflow, data management, and reporting capabilities of a clinical laboratory. It serves as a centralized repository for all laboratory data and test results, allowing for efficient communication between healthcare providers, laboratorians, and patients.
The CLIS typically includes modules for specimen tracking, order entry, result reporting, data analysis, and quality control. It interfaces with other hospital information systems such as the electronic health record (EHR), radiology information system (RIS), and pharmacy information system (PIS) to provide a comprehensive view of the patient's medical history and test results.
The CLIS is used to manage a wide range of laboratory tests, including clinical chemistry, hematology, microbiology, immunology, molecular diagnostics, and toxicology. It helps laboratories to streamline their operations, reduce errors, improve turnaround times, and enhance the overall quality of patient care.
In summary, a Clinical Laboratory Information System is an essential tool for modern clinical laboratories that enables them to manage large volumes of data, improve efficiency, and provide accurate and timely test results to healthcare providers and patients.
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
A laboratory (often abbreviated as lab) is a facility that provides controlled conditions in which scientific or technological research, experiments, and measurements may be performed. In the medical field, laboratories are specialized spaces for conducting diagnostic tests and analyzing samples of bodily fluids, tissues, or other substances to gain insights into patients' health status.
There are various types of medical laboratories, including:
1. Clinical Laboratories: These labs perform tests on patient specimens to assist in the diagnosis, treatment, and prevention of diseases. They analyze blood, urine, stool, CSF (cerebrospinal fluid), and other samples for chemical components, cell counts, microorganisms, and genetic material.
2. Pathology Laboratories: These labs focus on the study of disease processes, causes, and effects. Histopathology involves examining tissue samples under a microscope to identify abnormalities or signs of diseases, while cytopathology deals with individual cells.
3. Microbiology Laboratories: In these labs, microorganisms like bacteria, viruses, fungi, and parasites are cultured, identified, and studied to help diagnose infections and determine appropriate treatments.
4. Molecular Biology Laboratories: These labs deal with the study of biological molecules, such as DNA, RNA, and proteins, to understand their structure, function, and interactions. They often use techniques like PCR (polymerase chain reaction) and gene sequencing for diagnostic purposes.
5. Immunology Laboratories: These labs specialize in the study of the immune system and its responses to various stimuli, including infectious agents and allergens. They perform tests to diagnose immunological disorders, monitor immune function, and assess vaccine effectiveness.
6. Toxicology Laboratories: These labs analyze biological samples for the presence and concentration of chemicals, drugs, or toxins that may be harmful to human health. They help identify potential causes of poisoning, drug interactions, and substance abuse.
7. Blood Banks: Although not traditionally considered laboratories, blood banks are specialized facilities that collect, test, store, and distribute blood and its components for transfusion purposes.
Medical laboratories play a crucial role in diagnosing diseases, monitoring disease progression, guiding treatment decisions, and assessing patient outcomes. They must adhere to strict quality control measures and regulatory guidelines to ensure accurate and reliable results.
An Electronic Health Record (EHR) is a digital version of a patient's medical history that is stored and maintained electronically rather than on paper. It contains comprehensive information about a patient's health status, including their medical history, medications, allergies, test results, immunization records, and other relevant health information. EHRs can be shared among authorized healthcare providers, which enables better coordination of care, improved patient safety, and more efficient delivery of healthcare services.
EHRs are designed to provide real-time, patient-centered records that make it easier for healthcare providers to access up-to-date and accurate information about their patients. They can also help reduce errors, prevent duplicative tests and procedures, and improve communication among healthcare providers. EHRs may include features such as clinical decision support tools, which can alert healthcare providers to potential drug interactions or other health risks based on a patient's medical history.
EHRs are subject to various regulations and standards to ensure the privacy and security of patients' health information. In the United States, for example, EHRs must comply with the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule, which sets national standards for the protection of personal health information.
A controlled vocabulary in a medical context refers to a specific set of standardized terms and phrases that are used in clinical documentation and communication. These vocabularies are often created and maintained by professional organizations or governmental bodies to ensure consistency, accuracy, and interoperability in the sharing and retrieval of health information.
Controlled vocabularies can include terminologies such as Systematized Nomenclature of Medicine (SNOMED), International Classification of Diseases (ICD), Logical Observation Identifiers Names and Codes (LOINC), and RxNorm, among others. By using a controlled vocabulary, healthcare providers can more easily share and analyze health data, support clinical decision-making, and facilitate accurate coding and billing.
The Systematized Nomenclature of Medicine (SNOMED) is a systematically organized collection of medical terms that are used to describe medical diagnoses, findings, procedures, and other health-related concepts. It is a standardized terminology that is widely adopted in the field of healthcare and clinical research to facilitate accurate and consistent exchange of health information among different healthcare providers, institutions, and electronic health records (EHRs) systems.
SNOMED is designed to capture detailed clinical data and support effective clinical decision-making by providing a common language for describing and sharing clinical information. It includes over 350,000 concepts that are organized into hierarchies based on their relationships to each other. The hierarchical structure of SNOMED allows users to navigate through the terminology and find the most specific concept that describes a particular clinical phenomenon.
SNOMED is maintained by the International Health Terminology Standards Development Organization (IHTSDO), which is responsible for updating and expanding the terminology to reflect changes in medical knowledge and practice. SNOMED is used in many countries around the world, including the United States, Canada, Australia, and several European countries.
The No-Observed-Adverse-Effect Level (NOAEL) is a term used in toxicology and safety assessments, which refers to the highest dose or concentration of a chemical or substance that does not cause any harmful or adverse effects in test subjects during a specific study. It is typically determined through laboratory experiments on animals, where different doses of the substance are administered to various groups, and the effects are closely monitored and evaluated for a specified period. The NOAEL is established based on the dose at which no observable adverse effects were found in comparison to a control group that did not receive the substance. It serves as an essential reference point in risk assessment to estimate safe exposure levels for humans. However, it is important to note that extrapolating NOAEL values from animal studies to human health risks involves many uncertainties and assumptions.
Acute toxicity tests are a category of medical or biological testing that measure the short-term adverse effects of a substance on living organisms. These tests are typically performed in a laboratory setting and involve exposing test subjects (such as cells, animals, or isolated organs) to a single high dose or multiple doses of a substance within a short period of time, usually 24 hours or less.
The primary objective of acute toxicity testing is to determine the median lethal dose (LD50) or concentration (LC50) of a substance, which is the amount or concentration that causes death in 50% of the test subjects. This information can be used to help assess the potential health hazards associated with exposure to a particular substance and to establish safety guidelines for its handling and use.
Acute toxicity tests are required by regulatory agencies around the world as part of the process of evaluating the safety of chemicals, drugs, and other substances. However, there is growing concern about the ethical implications of using animals in these tests, and many researchers are working to develop alternative testing methods that do not involve the use of live animals.
Fatty alcohols, also known as long-chain alcohols or long-chain fatty alcohols, are a type of fatty compound that contains a hydroxyl group (-OH) and a long alkyl chain. They are typically derived from natural sources such as plant and animal fats and oils, and can also be synthetically produced.
Fatty alcohols can vary in chain length, typically containing between 8 and 30 carbon atoms. They are commonly used in a variety of industrial and consumer products, including detergents, emulsifiers, lubricants, and personal care products. In the medical field, fatty alcohols may be used as ingredients in certain medications or topical treatments.
Lanolin is not strictly a medical term, but it is often used in medical contexts. Medically, lanolin is referred to as "wool fat" or "wool wax." It's a yellow, waxy substance that is secreted by the sebaceous glands of wool-bearing animals, most notably sheep. Lanolin is composed primarily of esters, alcohols, and fatty acids, and it has excellent emollient properties, making it a valuable ingredient in various medical and cosmetic products.
In medical contexts, lanolin is often used as an emollient or moisturizer in topical preparations, such as creams, ointments, and lotions. It helps to soften and soothe dry, chapped, or irritated skin by creating a protective barrier that locks in moisture. Lanolin is also used in the pharmaceutical industry as an excipient (an inactive substance that serves as a vehicle or medium for a drug) in various formulations, including tablets and capsules.
It's worth noting that some people may have allergic reactions to lanolin, so it's essential to perform a patch test before using products containing this ingredient, especially if you have sensitive skin or a history of allergies.
Social isolation, in the context of health and medicine, refers to the lack of social connections, interactions, or engagement with other people or communities. It is a state of being separated from others, lacking companionship or meaningful communication, which can lead to feelings of loneliness and disconnection. Social isolation can be self-imposed or imposed by external factors such as mobility issues, loss of loved ones, or discrimination. Prolonged social isolation has been linked to various negative health outcomes, including mental health disorders, cognitive decline, and increased risk for chronic conditions like heart disease and stroke.
Salivation is the process of producing and secreting saliva by the salivary glands in the mouth. It is primarily a reflex response to various stimuli such as thinking about or tasting food, chewing, and speaking. Saliva plays a crucial role in digestion by moistening food and helping to create a food bolus that can be swallowed easily. Additionally, saliva contains enzymes like amylase which begin the process of digesting carbohydrates even before food enters the stomach. Excessive salivation is known as hypersalivation or ptyalism, while reduced salivation is called xerostomia.
'Arachis hypogaea' is the scientific name for the peanut plant. It is a legume crop that grows underground, which is why it is also known as a groundnut. The peanut plant produces flowers above ground, and when the flowers are pollinated, the ovary of the flower elongates and grows downwards into the soil where the peanut eventually forms and matures.
The peanut is not only an important food crop worldwide but also has various industrial uses, including the production of biodiesel, plastics, and animal feed. The plant is native to South America and was domesticated by indigenous peoples in what is now Brazil and Peru thousands of years ago. Today, peanuts are grown in many countries around the world, with China, India, and the United States being the largest producers.
NPU terminology
Autosplenectomy
Camptodactyly-arthropathy-coxa vara-pericarditis syndrome
Orders of magnitude (molar concentration)
Delta-beta thalassemia
Automated analyser
Thrombocythemia
Calabash chalk
HBS1 like translational GTPase
Eosinophilic pneumonia
Gout
Kathryn B. H. Clancy
ImageJ
Perilipin-5
Aagenaes syndrome
Peripheral ulcerative keratitis
Constance Tom Noguchi
Primary tumors of the heart
Hyperbilirubinemia in adults
Fibromyalgia
Clinical descriptions of chronic fatigue syndrome
Schnitzler syndrome
Denis Jourdanet
Psychogenic pruritus
Medical slang
Erythema nodosum
Kawasaki disease
Alimentary toxic aleukia
Boulengerula taitana
Microfluidics
Pott's disease
Erythrocyte Count (RBC): Reference Range, Interpretation, Collection and Panels
Erythrocyte Count | Profiles RNS
Erythrocyte Count (RBC Count) - Medha Diagnostics Nellore
Erythrocyte Count (RBC): Reference Range, Interpretation, Collection and Panels
Erythrocyte Count (RBC): Reference Range, Interpretation, Collection and Panels
The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans - Wellcome...
Body fluid cycle - HORIBA Yumizen H2500 hematology analyzer
RBC count: MedlinePlus Medical Encyclopedia
RTECS:AS1050000 - Acrolein - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH
Benefin CASRN 1861-40-1 | DTXSID3023899 | IRIS | US EPA, ORD
First Isolation of West Nile virus from a Patient with Encephalitis in the United States - Volume 8, Number 12-December 2002 -...
NPU terminology - Wikipedia
Registration Dossier - ECHA
Registration Dossier - ECHA
Registration Dossier - ECHA
Registration Dossier - ECHA
Advanced Search Results - Public Health Image Library(PHIL)
Complete Blood Count (CBC) Test: Results, Chart, Ranges & Values
IndexCat
Riverland Laboratory - Accredited Organisation (Site No. 5821) - NATA
Erowid.org: Erowid Reference 8734 : Prazosin and priapism : Bhalla AK, Hoffbrand BI, Phatak PS, Reuben SR
Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult...
Coccidioidomycosis and Valley Fever Workup: Approach Considerations, Serologic Studies, Cultures
Erowid.org: Erowid Reference 1490 : Ascorbic acid, glucose-l-phosphate, and lysergic-acid diethylamide in rheumatoid arthritis....
Erythrocyte definition | Health Dictionary
NIOSHTIC-2 Search Results - Full View
Acrylonitrile (EHC 28, 1983)
Sedimentation rate12
- we analysed its effect on fever, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, numbers of swollen and tender joints, the assessment of disease activity (by physician and parent/patient) and pain (by parent/patient), and American College of Rheumatology (ACR) pediatric core set criteria for JIA activity. (bmj.com)
- General laboratory tests include a complete blood count (CBC) and erythrocyte sedimentation rate (ESR). (medscape.com)
- Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have been studied previously in this regard and were not useful. (amrita.edu)
- for complete blood count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and DNA isolation. (exposed-skin-care.net)
- These can include a complete blood count, blood chemistry, and erythrocyte sedimentation rate (ESR) to look for evidence of inflammation. (dana-farber.org)
- Other common acute phase reactants include the ESR (Erythrocyte Sedimentation Rate) and blood platelet count. (successcds.net)
- Tests for markers of inflammation, such as C-reactive protein and Erythrocyte sedimentation rate (ESR). (kyoto2.org)
- The research was conducted to observe the effect of shoti meal on weight gain and some selected hematological values such as total erythrocyte count (TEC), hemoglobin (Hb) and erythrocyte sedimentation rate (ESR) and biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), uric acid and creatinine in broilers. (banglajol.info)
- Investigations showed normal white cell count, C-reactive protein, erythrocyte sedimentation rate, and a negative vasculitis profile. (neurology.org)
- These analyzers offer complete blood count (CBC) and erythrocyte sedimentation rate (ESR) testing capabilities. (factmr.com)
- White blood cell count and erythrocyte sedimentation rate are normal. (msdmanuals.com)
- Pulmonary tuberculosis count, erythrocyte sedimentation rate, be aware of such toxicity. (who.int)
Platelet6
- Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. (ox.ac.uk)
- No significant changes occurred in leukocyte or platelet counts. (cdc.gov)
- p class=\'abstract\'>Cyclic thrombocytopenia (CTP) is a rare disease of periodic platelet count oscillations. (stanford.edu)
- Blood transcriptome analysis revealed cycling of platelet-specific genes, which are in parallel with and precede platelet count oscillation, indicating that cyclical platelet production leads platelet count cycling in both patients. (stanford.edu)
- Additionally, neutrophil and erythrocyte-specific genes also showed fluctuations correlating with platelet count changes, consistent with TPO effects on hematopoietic progenitors. (stanford.edu)
- In addition, both patients had clonal T-cell populations that remained stable throughout platelet count cycles. (stanford.edu)
Leukocyte3
- 74 out of 98 samples were used to compare leukocyte and erythrocyte count. (horiba.com)
- The correlation coefficient between the 2 analyzers was 0.991 for leukocyte (figure 2) and 0.955 between Yumizen H2500 and the conventional chamber counting method (figure 3). (horiba.com)
- In addition, data from this study allowed the leukocyte count and the scattergram thresholds used for the differential to be optimized. (horiba.com)
Protein1
- Erythrocytes contain iron and HEMOGLOBIN, a pigmented protein that gives them their red color. (beltina.org)
Hematocrit3
- Red blood cell count is part of a standard complete blood count (CBC) and is used along with hemoglobin concentration and hematocrit to determine if a patient has anemia , polycythemia, dehydration, or response to treatment related to those conditions. (medscape.com)
- The RBC count usually rises or falls along with hemoglobin or hematocrit. (medscape.com)
- Red blood cell count along with hemoglobin concentration, and hematocrit should be interpreted with cautions because the measurement is relative to plasma volume. (medscape.com)
Polycythemia vera1
- RBC count then increases either due to relatively decreased plasma volume such as dehydration/hemoconcentration or due to absolute increase in red blood cell production such as in renal cell carcinoma (due to erythropoietin production) or polycythemia vera. (medscape.com)
Hemoglobin content1
- variability in number, size and hemoglobin content of the erythrocytes during the first 5 years of life. (nih.gov)
Complete blood18
- The RBC count is almost always part of a complete blood count ( CBC ) test. (medlineplus.gov)
- What Is a Complete Blood Count (CBC) Test? (emedicinehealth.com)
- The complete blood count (CBC) test is one of the most commonly ordered blood tests. (emedicinehealth.com)
- The complete blood count test measures the quantity of all the different types of cells in the blood. (emedicinehealth.com)
- The complete blood count test is performed by drawing a few milliliters (one to two teaspoons) of blood from a vein. (emedicinehealth.com)
- The complete blood count may be done in many different healthcare settings including doctors' offices, clinics, urgent care facilities, emergency rooms, hospitals, and outpatient medical laboratories. (emedicinehealth.com)
- This sample is then taken to the laboratory for analysis, and the complete blood count results may be available within hours after collection. (emedicinehealth.com)
- What Are Components of Complete Blood Count? (emedicinehealth.com)
- The complete blood count interpretation is done by doctors who review the results of the testing. (emedicinehealth.com)
- The complete blood count measures many important values pertaining to the blood cells. (emedicinehealth.com)
- The different types of WBCs that have specific functions that are routinely reported in a complete blood count are neutrophils, lymphocytes, basophils, eosinophils, and monocytes. (emedicinehealth.com)
- What Is an Analysis of the Complete Blood Count? (emedicinehealth.com)
- The blood sample drawn for a complete blood count is analyzed in a medical laboratory. (emedicinehealth.com)
- The complete blood count analysis is routinely and reliably done by automated machines in most laboratories. (emedicinehealth.com)
- A small sample of the blood drawn from a person is fed into the machine and within a few minutes, the values of the components of the complete blood count are displayed and printed for review. (emedicinehealth.com)
- This method is still widely used when results of a complete blood count need further review to confirm certain abnormal values, or a doctor wants to see how the blood cells look (for example, if any abnormal features are present which would not be reported by an automated complete blood count). (emedicinehealth.com)
- Routine screening tests for undifferentiated connective-tissue disease (UCTD) should include the following: Complete blood count. (kyoto2.org)
- The complete blood count showed low values for red cells. (bvsalud.org)
Bacterial1
- Also, the results of the bacterial reverse mutation test and the erythrocyte micronucleus assay in mouse bone marrow suggest that CinDura® (GMCT) is neither mutagenic nor clastogenic. (hindawi.com)
Bone1
- The BONE MARROW thus must continuously produce erythrocytes, which it does at the rate of about 2 million per minute. (beltina.org)
Estimation1
- Estimation of erythrocytes from a blood smear by a dry chamber method. (nih.gov)
Carries1
- Erythrocytes account for 99 percent of the blood cells the blood carries. (beltina.org)
Conventional2
- Results were compared to a conventional microscopic count and to the XN10 (Sysmex) reference analyzer in body fluid mode. (horiba.com)
- This study confirmed the good analytical performance of the Yumizen H2500 in comparison with conventional microscopic count as well as with the XN10 analyzer. (horiba.com)
Anemia2
- RBC count decreases in anemia or blood loss. (medscape.com)
- My clinic includes all types of hematologic disorders, ranging from anemia, clotting/bleeding disorders, and low blood counts to complex malignancies such as leukemia, myelodysplastic syndrome, myeloma, and lymphoma. (stanford.edu)
Significantly1
- Similarly, the range of erythrocyte count of healthy patients was significantly higher (3.69-5.29 million/µl) than chronic periodontitis patients (3.33-5.97 million/µl). (bvsalud.org)
White2
- Background: Prediction of outcome in diabetic foot infection (DFI) remains difficult due to lack of active signs of infection, and apparently normal white blood cell (WBC) count. (amrita.edu)
- If an infectious etiology is suspected (due to the presence of fever, erythema, previous puncture wounds, or cellulitis), the olecranon bursa should be aspirated and the fluid sent for culture, for a cell count (white blood cells [WBCs], red blood cells [RBCs]), and for Gram staining for bacteria. (medscape.com)
Venous2
- Relation between hemoglobin, cell count and cell volume in the venous blood of normal human subjects. (nih.gov)
- Under aseptic conditions, venous blood samples were obtained by vein-puncture in the ante-cubital fossa without excessive venous stasis and the mean value of erythrocytes (EC), hemoglobin concentration (HGB), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were measured. (bvsalud.org)
Variability1
- Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. (ox.ac.uk)
Percentage2
- The hemoglobin percentage and red blood cell count in Bright's disease, myocardial insufficiency and hypertension. (nih.gov)
- Men have a somewhat higher percentage of erythrocytes in their blood, about 47 percent, than women, who have about 42 percent, primarily because women lose blood each month with MENSTRUATION . (beltina.org)
Lungs1
- The primary function of erythrocytes is to carry oxygen from the LUNGS to the cells of tissues throughout the body and return carbon dioxide, a metabolic waste, to the lungs for removal from the body. (beltina.org)
Method2
Decrease1
- NOEL = 20 mg/kg (A male at 200 mg/kg was killed moribund, due to a severe weight decrease (2 kg), decreased hemoglobin and RBC counts. (fluoridealert.org)
Test1
- An RBC count is a blood test that measures how many red blood cells (RBCs) you have. (medlineplus.gov)
Subjects1
- WBC count, ESR, CRP, and PCT were done for all subjects at admission after obtaining informed consent. (amrita.edu)
Volume1
- Red blood cell (RBC) count is a number of red blood cells per unit volume of blood. (medscape.com)
Abnormal2
- The samples were analyzed in duplicate by the Yumizen H2500 to determine the number of leukocytes and erythrocytes, the partial formula (% of mononuclear cells (%MN) and % of polymorphonuclear cells (%PN)) and to detect abnormal cells. (horiba.com)
- The presence of abnormal plasma cells in the sample caused discrepant results between both analyzers (figure 4B, figure 6) and between the Yumizen H2500 and manual count. (horiba.com)
Diagnosis1
- Red blood cell (RBC) count can also be used with MCV to aid in the differential diagnosis between iron deficiency and β- or α-thalassemia trait. (medscape.com)
Total1
- This graph shows the total number of publications written about "Erythrocyte Count" by people in this website by year, and whether "Erythrocyte Count" was a major or minor topic of these publications. (jefferson.edu)
Types1
- Peu de types de voix humaines peuvent être considérés comme étant aux confins de la vocalité et de la théorie queer , mais celui de la vocalité transsexuelle de la femme vers l'homme (FTM), à savoir la transvocalité, en serait le meilleur exemple. (openedition.org)
Cells1
- Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). (ox.ac.uk)
Cell1
- This is called an automated cell count and differential. (emedicinehealth.com)
Effect1
- Gluce-l-phosphate and LSD had no effect on eosinophil counts or erythrocyte sedimentation rates. (erowid.org)
Higher1
- Your RBC count will increase for several weeks when you are in a higher altitude. (medlineplus.gov)
People1
- Below are the most recent publications written about "Erythrocyte Count" by people in Profiles. (jefferson.edu)
Study1
- A study of the erythrocyte curve at various ages and its relationship to hemoglobin curve. (nih.gov)
Full1
- Full blood count, erythrocyte sedi- fourth left finger. (cdc.gov)
Approximately2
- No particle counts above the minimum resolvable level (approximately 200 particles/cm3) were detected. (europa.eu)
- For each patient, we analysed all the blood counts carried out approximately 16 to 18 days after the previous treatment session, and 3 to 5 days before the following one. (bvsalud.org)
Plasma1
- Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate across the plasma membrane of erythrocytes. (rcsb.org)