An autosomal dominant inherited partial epilepsy syndrome with onset between age 3 and 13 years. Seizures are characterized by PARESTHESIA and tonic or clonic activity of the lower face associated with drooling and dysarthria. In most cases, affected children are neurologically and developmentally normal. (From Epilepsia 1998 39;Suppl 4:S32-S41)
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Recurrent conditions characterized by epileptic seizures which arise diffusely and simultaneously from both hemispheres of the brain. Classification is generally based upon motor manifestations of the seizure (e.g., convulsive, nonconvulsive, akinetic, atonic, etc.) or etiology (e.g., idiopathic, cryptogenic, and symptomatic). (From Mayo Clin Proc, 1996 Apr;71(4):405-14)
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)
Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)
A clinically diverse group of epilepsy syndromes characterized either by myoclonic seizures or by myoclonus in association with other seizure types. Myoclonic epilepsy syndromes are divided into three subtypes based on etiology: familial, cryptogenic, and symptomatic (i.e., occurring secondary to known disease processes such as infections, hypoxic-ischemic injuries, trauma, etc.).
Drugs used to prevent SEIZURES or reduce their severity.
A subtype of epilepsy characterized by seizures that are consistently provoked by a certain specific stimulus. Auditory, visual, and somatosensory stimuli as well as the acts of writing, reading, eating, and decision making are examples of events or activities that may induce seizure activity in affected individuals. (From Neurol Clin 1994 Feb;12(1):57-8)
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
A disorder characterized by the onset of myoclonus in adolescence, a marked increase in the incidence of absence seizures (see EPILEPSY, ABSENCE), and generalized major motor seizures (see EPILEPSY, TONIC-CLONIC). The myoclonic episodes tend to occur shortly after awakening. Seizures tend to be aggravated by sleep deprivation and alcohol consumption. Hereditary and sporadic forms have been identified. (From Adams et al., Principles of Neurology, 6th ed, p323)
A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Area of the parietal lobe concerned with receiving sensations such as movement, pain, pressure, position, temperature, touch, and vibration. It lies posterior to the central sulcus.
Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex.
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)
A localization-related (focal) form of epilepsy characterized by seizures which arise in the FRONTAL LOBE. A variety of clinical syndromes exist depending on the exact location of the seizure focus. Frontal lobe seizures may be idiopathic (cryptogenic) or caused by an identifiable disease process such as traumatic injuries, neoplasms, or other macroscopic or microscopic lesions of the frontal lobes (symptomatic frontal lobe seizures). (From Adams et al., Principles of Neurology, 6th ed, pp318-9)
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)
A syndrome characterized by the onset of isolated language dysfunction in otherwise normal children (age of onset 4-7 years) and epileptiform discharges on ELECTROENCEPHALOGRAPHY. Seizures, including atypical absence (EPILEPSY, ABSENCE), complex partial (EPILEPSY, COMPLEX PARTIAL), and other types may occur. The electroencephalographic abnormalities and seizures tend to resolve by puberty. The language disorder may also resolve although some individuals are left with severe language dysfunction, including APHASIA and auditory AGNOSIA. (From Menkes, Textbook of Child Neurology, 5th ed, pp749-50; J Child Neurol 1997 Nov;12(8):489-495)
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
The appearance of the face that is often characteristic of a disease or pathological condition, as the elfin facies of WILLIAMS SYNDROME or the mongoloid facies of DOWN SYNDROME. (Random House Unabridged Dictionary, 2d ed)
The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
A childhood seizure disorder characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)
Printed publications usually having a format with no binding and no cover and having fewer than some set number of pages. They are often devoted to a single subject.
A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.

Benign rolandic epilepsy: neuropsychological findings. (1/45)

Benign rolandic epilepsy (BRE) is a partial idiopathic epilepsy of childhood presenting with a nocturnal seizure and with a typical EEG showing centrotemporal spike and multifocal or generalized sharp slow waves. Although normal neurological and intellectual development are expected in BRE, it is not infrequent to detect subtle defects in neuropsychological functions and neuromotor development. This study included 20 cases of BRE diagnosed according to the criteria of ILAE. The patients underwent several tests of neuropsychological functions as well as detailed neurological examination and the results were compared statistically to normal controls. In the patient group, a family history of language delay or learning disability (P < 0.005), presence of consanguinity (P < 0. 05), dyspraxia in the lower extremities (to imitation) (P < 0.05), difficulties in go-no-go test (P < 0.001), as well as some problems related to language such as dysprosody (P = 0.05), minor motor deficits in the left (P < 0.05) and right upper extremity (P < 0.05) were significantly more frequent compared to the control group. One should be rather guarded against the prognosis in BRE with respect to the higher cortical functions and neurodevelopmental problems.  (+info)

Benign rolandic epilepsy: clinical and electroencephalographic correlates. (2/45)

Benign rolandic epilepsy (BRE) is known for its dissociation from structural alterations. Nevertheless, the number of cases with reported organic lesions has been increasing. This led to the creation of two subgroups, "benign" and "non benign" BRE, and resulted in the need for additional parameters to define electrographic benignity. We assessed the possible associations between interictal electroencephalographic findings and clinical behavior in 60 BRE cases, testing four parameters of electrographic benignity (paroxysm morphology, horizontal dipole, base rhythms, laterality of rolandic spikes). We also assessed the relationship between neuroimaging findings and electrographic and clinical classifications, and found a statistically significant association (sensitivity=73.5%; specificity=81.8%; positive predictive value=94. 8%; negative predictive value=40.9%). Three of the electrographic parameters proposed were associated with clinical classification: paroxysm morphology, horizontal dipole, and base rhythms. Cases electrographically classified as benign have 21 times more chances to be equally classified as clinically benign according with the tested criteria.  (+info)

Clinical correlations of electroencephalographic occipital epileptiform paroxysms in children. (3/45)

A longitudinal prospective approach was used to investigate clinical correlations of interictal occipital paroxysms with or without fixation-off sensitivity (FOS). Occipital paroxysms were recorded in the electroencephalograms (EEGs) of 76 children with heterogeneous clinical conditions including seizures in 39 patients. Occipital paroxysms with FOS (42 patients ) were only fractionally more frequent than non-FOS (34 patients ) and were not specific of any clinical condition. Although present and FOS-related in all 11 children with benign childhood epilepsies with occipital paroxysms (CEOP), they were also frequently encountered in symptomatic occipital epilepsy. The differentiation of CEOP from other syndromes established on clinical grounds could also be aided by the analysis of background EEG activity that was frequently significantly more abnormal in symptomatic than CEOP. Clinical characteristics and ictal seizure semiology as well as follow-up clearly distinguish two type of idiopathic CEOP syndromes: (1) early onset type or Panayiotopoulos syndrome characterized by excellent prognosis and rare, prolonged nocturnal seizures with tonic deviations of the eyes and vomiting, and (2) late onset or Gastaut type showing a common ictal visual symptomatology, co-occurrence of migraine, diurnal complex partial seizures and less favourable EEG-clinical prognosis.  (+info)

Seizure's outcome after cortical resections including the face and tongue rolandic areas in patients with refractory epilepsy and normal MRI submitted to subdural grids' implantation. (4/45)

PURPOSE: To study the seizure's outcome in patients with refractory epilepsy and normal MRI submitted to resections including the rolandic cortex. METHODS: Four adult patients were studied. All patients had motor or somatosensory simple partial seizures and normal MRI and were submitted to subdural grids' implantation with extensive coverage of the cortical convexity (1 in the non-dominant and 3 in the dominant hemisphere). RESULTS: ECoG was able to define focal areas of seizures' onset in every patient. All patients were submitted to resection of the face and tongue motor and sensitive cortex; two patients had resections including the perirolandic cortex and 2 had additional cortical removals. Three patients are seizures' free and one had a greater then 90% reduction in seizure frequency. CONCLUSION: Resections including the face and tongue rolandic cortex can be safely performed even within the dominant hemisphere.  (+info)

Phenobarbital-induced atypical absence seizure in benign childhood epilepsy with centrotemporal spikes. (5/45)

This report describes atypical absence seizures induced by phenobarbital (PB) in a patient with benign childhood epilepsy with centrotemporal spikes. An 11-year-old girl had nocturnal motor seizures, beginning at the age of 7 years. Interictal EEG displayed centrotemporal sharp waves in the left and right sides alternatively, which increased significantly in frequency during sleep. She was given a diagnosis of benign childhood epilepsy with centrotemporal spike and was treated with valproic acid (VPA), which controlled her seizures for 3 years. She experienced nocturnal Rolandic seizures again, at the age of 10 years 2 months, 10 years 10 months in spite of the regular medication, and PB 60 mg daily was added to the VPA. Her parents noted de novo a few seconds of unresponsive fits 7 days after PB administration. Ictal EEG of the fits revealed diffuse irregular spike and wave bursts (1-4 seconds). VPA and PB in her blood was within the therapeutic ranges. After discontinuing PB, the atypical absence seizures immediately disappeared. Phenobarbital should be added to the list of drugs that potentially provoke de novo seizures.  (+info)

Benign focal epilepsy of childhood with centrotemporal spikes (BECTS): clinical characteristics of seizures according to age at first seizure. (6/45)

BECTS is characterized by the presence of simple partial motor seizures in the face and/or oropharynx, with or without sensory symptoms and often with secondary generalization. These seizures tend to occur more often during sleep or drowsiness. According to some authors, generalized seizures prevail over other types particularly among children aged five or less. The purpose of this study is to determine the characteristics of the first epileptic episode among children with BECTS, grouped by age as of their first epileptic seizure, as well as to analyze how such seizures change over the course of clinical evolution. A total of 61 children were examined, 16 of whom below the age of 5 and 45 above. With regard to the first and recurrent epileptic episodes, our final assessment showed that partial seizures occurred more frequently than generalized tonic-clonic seizures in both groups. Although no conclusive relation could be established between the type of partial seizure (i.e. simple versus complex) and the children's age as of their first epileptic episode, it was possible to correlate the type of epileptic seizure with their clinical evolution, in which case simple partial seizures proved to be more frequent than complex partial seizures. It should be noted that the number of children under the age of five was relatively small, which evidences the need for further studies. It should also be borne in mind that the reported frequency of generalized seizures in these children's first epileptic episode may be due to their parents' lack of attention and familiarity with this pathology and their attendant difficulty in characterizing its clinical symptoms.  (+info)

A comparison between averaged spikes and individual visually-analyzed spikes in rolandic epileptiform discharges. (7/45)

PURPOSE: This study compared some morphological features of individual rolandic epileptiform discharges, used to obtain an averaged estimate, with those of the resulting estimate. METHOD: Twenty-four averaged discharges from EEGs of 24 children showing rolandic spikes were compared with 480 individual discharges used in the averaging. The analysis was based on the occurrence of tangential dipole and "double spike" patterns. RESULTS: In 15 averaged discharges the tangential dipole pattern was found. Individual spikes used in the averaging process displayed the same pattern in 35-100% of them; in the remaining 9 averaged discharges, up to 20% of the individual spikes showed the same pattern, although this was not found in the averaged waveforms. "Double spike" pattern was found in 11 of the averaged waveforms and was recognized in 50-100% of its individual discharges, whereas up to 45% of individual spikes showed this pattern without expression in the averaged waveform. CONCLUSION: When visually analyzing an EEG with rolandic spikes, caution should be exercised in characterizing these patterns, since a few discharges showing them may not be expressed in the averaged waveform and the clinical correlations proposed for these patterns may not apply.  (+info)

Atypical benign partial epilepsy of childhood (pseudo-Lennox syndrome): report of two brothers. (8/45)

Two brothers (3 and 2 year old) with characteristic findings of atypical benign partial epilepsy of childhood (pseudo-Lennox syndrome) are reported, to emphasize the presence of a possibility of a genetic basis of this disorder and the importance of intravenous immune globulin (IVIG), vigabatrin (VGB) and lamotrigine (LTG) therapy. Sleep EEGs of both the patients showed typical features of Lennox-Gastaut syndrome. On follow-up, the convulsions were found to be resistant to numerous antiepileptic agents in one patient while they were easily controlled with LTG monotherapy in the other patient. In the elder brother, who was diagnosed as intractable epilepsy, the convulsions disappeared with IVIG and VGB. During the long term follow-up, they were seizure free for five and two years respectively, and their mental motor development was excellent.  (+info)

Rolandic epilepsy, also known as benign focal epilepsy of childhood with centrotemporal spikes (BFEC), is a type of epilepsy that primarily affects children. It is called "Rolandic" because the seizures often originate in or near the Rolandic area of the brain, which is involved in speech and motor function.

The hallmark feature of Rolandic epilepsy is focal seizures that typically involve tingling or numbness sensations on one side of the face, tongue, or mouth, followed by speech difficulties and sometimes weakness or jerking movements on one side of the body. These seizures usually occur during sleep or drowsiness and can cause awakening from sleep.

Rolandic epilepsy is typically outgrown by adolescence, and many children with this condition do not require long-term treatment. However, some children may experience cognitive or behavioral difficulties that warrant evaluation and management.

It's important to note that while Rolandic epilepsy is considered benign, it can still have a significant impact on a child's quality of life and daily functioning. Proper diagnosis and management are essential to ensure the best possible outcomes for children with this condition.

Epilepsy is a chronic neurological disorder characterized by recurrent, unprovoked seizures. These seizures are caused by abnormal electrical activity in the brain, which can result in a wide range of symptoms, including convulsions, loss of consciousness, and altered sensations or behaviors. Epilepsy can have many different causes, including genetic factors, brain injury, infection, or stroke. In some cases, the cause may be unknown.

There are many different types of seizures that can occur in people with epilepsy, and the specific type of seizure will depend on the location and extent of the abnormal electrical activity in the brain. Some people may experience only one type of seizure, while others may have several different types. Seizures can vary in frequency, from a few per year to dozens or even hundreds per day.

Epilepsy is typically diagnosed based on the patient's history of recurrent seizures and the results of an electroencephalogram (EEG), which measures the electrical activity in the brain. Imaging tests such as MRI or CT scans may also be used to help identify any structural abnormalities in the brain that may be contributing to the seizures.

While there is no cure for epilepsy, it can often be effectively managed with medication. In some cases, surgery may be recommended to remove the area of the brain responsible for the seizures. With proper treatment and management, many people with epilepsy are able to lead normal, productive lives.

Generalized epilepsy is a type of epilepsy characterized by seizures that involve both halves of the brain (generalized onset) from the beginning of the seizure. These types of seizures include tonic-clonic (grand mal) seizures, absence (petit mal) seizures, and myoclonic seizures. Generalized epilepsy can be caused by genetic factors or brain abnormalities, and it is typically treated with medication. People with generalized epilepsy may experience difficulties with learning, memory, and behavior, and they may have a higher risk of injury during a seizure. It's important for individuals with generalized epilepsy to work closely with their healthcare team to manage their condition and reduce the frequency and severity of seizures.

Electroencephalography (EEG) is a medical procedure that records electrical activity in the brain. It uses small, metal discs called electrodes, which are attached to the scalp with paste or a specialized cap. These electrodes detect tiny electrical charges that result from the activity of brain cells, and the EEG machine then amplifies and records these signals.

EEG is used to diagnose various conditions related to the brain, such as seizures, sleep disorders, head injuries, infections, and degenerative diseases like Alzheimer's or Parkinson's. It can also be used during surgery to monitor brain activity and ensure that surgical procedures do not interfere with vital functions.

EEG is a safe and non-invasive procedure that typically takes about 30 minutes to an hour to complete, although longer recordings may be necessary in some cases. Patients are usually asked to relax and remain still during the test, as movement can affect the quality of the recording.

Temporal lobe epilepsy (TLE) is a type of focal (localized) epilepsy that originates from the temporal lobes of the brain. The temporal lobes are located on each side of the brain and are involved in processing sensory information, memory, and emotion. TLE is characterized by recurrent seizures that originate from one or both temporal lobes.

The symptoms of TLE can vary depending on the specific area of the temporal lobe that is affected. However, common symptoms include auras (sensory or emotional experiences that occur before a seizure), strange smells or tastes, lip-smacking or chewing movements, and memory problems. Some people with TLE may also experience automatisms (involuntary movements such as picking at clothes or fumbling with objects) during their seizures.

Treatment for TLE typically involves medication to control seizures, although surgery may be recommended in some cases. The goal of treatment is to reduce the frequency and severity of seizures and improve quality of life.

Epilepsy, partial is a type of epilepsy characterized by recurrent, unprovoked seizures that originate in a specific, localized area of the brain. These seizures are also known as focal seizures and can vary in severity and symptoms depending on the location of the abnormal electrical activity in the brain.

Partial epilepsies can be further classified into two main categories: simple partial seizures and complex partial seizures. Simple partial seizures do not involve a loss of consciousness, while complex partial seizures are associated with impaired awareness or responsiveness during the seizure.

The causes of partial epilepsies can include brain injury, infection, stroke, tumors, genetic factors, or an unknown cause. Treatment typically involves anti-seizure medications, and in some cases, surgery may be recommended to remove the specific area of the brain responsible for the seizures.

Myoclonic epilepsies are a group of epilepsy syndromes characterized by the presence of myoclonic seizures. A myoclonic seizure is a type of seizure that involves quick, involuntary muscle jerks or twitches. These seizures can affect one part of the body or multiple parts simultaneously and may vary in frequency and severity.

Myoclonic epilepsies can occur at any age but are more common in infancy, childhood, or adolescence. Some myoclonic epilepsy syndromes have a genetic basis, while others may be associated with brain injury, infection, or other medical conditions.

Some examples of myoclonic epilepsy syndromes include:

1. Juvenile Myoclonic Epilepsy (JME): This is the most common type of myoclonic epilepsy and typically begins in adolescence. It is characterized by myoclonic jerks, often occurring upon awakening or after a period of relaxation, as well as generalized tonic-clonic seizures.
2. Progressive Myoclonic Epilepsies (PME): These are rare inherited disorders that typically begin in childhood or adolescence and involve both myoclonic seizures and other types of seizures. PMEs often progress to include cognitive decline, movement disorders, and other neurological symptoms.
3. Lennox-Gastaut Syndrome (LGS): This is a severe form of epilepsy that typically begins in early childhood and involves multiple types of seizures, including myoclonic seizures. LGS can be difficult to treat and often results in cognitive impairment and developmental delays.
4. Myoclonic Astatic Epilepsy (MAE): Also known as Doose syndrome, MAE is a childhood epilepsy syndrome characterized by myoclonic seizures, atonic seizures (brief periods of muscle weakness or loss of tone), and other types of seizures. It often responds well to treatment with antiepileptic drugs.

The management of myoclonic epilepsies typically involves a combination of medication, lifestyle changes, and, in some cases, dietary modifications. The specific treatment plan will depend on the type of myoclonic epilepsy and its underlying cause.

Anticonvulsants are a class of drugs used primarily to treat seizure disorders, also known as epilepsy. These medications work by reducing the abnormal electrical activity in the brain that leads to seizures. In addition to their use in treating epilepsy, anticonvulsants are sometimes also prescribed for other conditions, such as neuropathic pain, bipolar disorder, and migraine headaches.

Anticonvulsants can work in different ways to reduce seizure activity. Some medications, such as phenytoin and carbamazepine, work by blocking sodium channels in the brain, which helps to stabilize nerve cell membranes and prevent excessive electrical activity. Other medications, such as valproic acid and gabapentin, increase the levels of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which has a calming effect on nerve cells and helps to reduce seizure activity.

While anticonvulsants are generally effective at reducing seizure frequency and severity, they can also have side effects, such as dizziness, drowsiness, and gastrointestinal symptoms. In some cases, these side effects may be managed by adjusting the dosage or switching to a different medication. It is important for individuals taking anticonvulsants to work closely with their healthcare provider to monitor their response to the medication and make any necessary adjustments.

Reflex epilepsy is a type of epilepsy in which seizures are consistently triggered by specific, recurring sensory stimuli. These triggers can vary widely and may include visual patterns, flashes of light, touch, sound, or even emotional experiences. When the brain receives input from these triggers, it responds with an abnormal electrical discharge that can lead to a seizure.

Reflex epilepsy is relatively rare, accounting for only about 5-10% of all epilepsy cases. It's important to note that not everyone who experiences seizures in response to these triggers has reflex epilepsy; the defining characteristic of this condition is the consistent and reproducible nature of the seizure response to a specific stimulus.

There are several different types of reflex epilepsy, each characterized by its own unique set of triggers. For example, some people with this condition may experience seizures in response to visual patterns or flashes of light (known as photosensitive epilepsy), while others may have seizures triggered by certain sounds or tactile sensations.

Treatment for reflex epilepsy typically involves identifying and avoiding triggers whenever possible, as well as using medication to control seizures. In some cases, surgery may be recommended to remove the specific area of the brain that is responsible for the abnormal electrical activity. With proper treatment and management, many people with reflex epilepsy are able to lead full and active lives.

The cerebral cortex is the outermost layer of the brain, characterized by its intricate folded structure and wrinkled appearance. It is a region of great importance as it plays a key role in higher cognitive functions such as perception, consciousness, thought, memory, language, and attention. The cerebral cortex is divided into two hemispheres, each containing four lobes: the frontal, parietal, temporal, and occipital lobes. These areas are responsible for different functions, with some regions specializing in sensory processing while others are involved in motor control or associative functions. The cerebral cortex is composed of gray matter, which contains neuronal cell bodies, and is covered by a layer of white matter that consists mainly of myelinated nerve fibers.

Brain mapping is a broad term that refers to the techniques used to understand the structure and function of the brain. It involves creating maps of the various cognitive, emotional, and behavioral processes in the brain by correlating these processes with physical locations or activities within the nervous system. Brain mapping can be accomplished through a variety of methods, including functional magnetic resonance imaging (fMRI), positron emission tomography (PET) scans, electroencephalography (EEG), and others. These techniques allow researchers to observe which areas of the brain are active during different tasks or thoughts, helping to shed light on how the brain processes information and contributes to our experiences and behaviors. Brain mapping is an important area of research in neuroscience, with potential applications in the diagnosis and treatment of neurological and psychiatric disorders.

Juvenile Myoclonic Epilepsy (JME) is a genetic condition that is characterized by the occurrence of myoclonic seizures, which are sudden, brief, shock-like jerks of muscles typically occurring in the arms and legs. These seizures usually begin in adolescence or early adulthood, between 12 to 18 years of age.

JME is a type of generalized epilepsy, meaning that it involves abnormal electrical activity throughout the brain rather than just one area. In addition to myoclonic seizures, individuals with JME may also experience absence seizures (brief periods of staring and unresponsiveness) and/or tonic-clonic seizures (generalized convulsions).

The condition is often inherited in an autosomal dominant manner, meaning that a child has a 50% chance of inheriting the gene mutation from a parent with JME. However, not all cases are familial, and some may result from new genetic changes (mutations) that occur spontaneously.

JME is typically treated with anticonvulsant medications such as valproate or lamotrigine to control seizures. Lifestyle modifications, including avoiding sleep deprivation, stress, and excessive alcohol consumption, may also help reduce the frequency of seizures. With appropriate treatment, most individuals with JME can lead normal or near-normal lives.

Tonic-clonic epilepsy, also known as grand mal epilepsy, is a type of generalized seizure that affects the entire brain. This type of epilepsy is characterized by two distinct phases: the tonic phase and the clonic phase.

During the tonic phase, which usually lasts for about 10-20 seconds, the person loses consciousness and their muscles stiffen, causing them to fall to the ground. This can result in injuries if the person falls unexpectedly or hits an object on the way down.

The clonic phase follows immediately after the tonic phase and is characterized by rhythmic jerking movements of the limbs, face, and neck. These movements are caused by alternating contractions and relaxations of the muscles and can last for several minutes. The person may also lose bladder or bowel control during this phase.

After the seizure, the person may feel tired, confused, and disoriented. They may also have a headache, sore muscles, and difficulty remembering what happened during the seizure.

Tonic-clonic epilepsy can be caused by a variety of factors, including genetics, brain injury, infection, or stroke. It is typically diagnosed through a combination of medical history, physical examination, and diagnostic tests such as an electroencephalogram (EEG) or imaging studies. Treatment may include medication, surgery, or dietary changes, depending on the underlying cause and severity of the seizures.

Medical Definition:

Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic imaging technique that uses a strong magnetic field and radio waves to create detailed cross-sectional or three-dimensional images of the internal structures of the body. The patient lies within a large, cylindrical magnet, and the scanner detects changes in the direction of the magnetic field caused by protons in the body. These changes are then converted into detailed images that help medical professionals to diagnose and monitor various medical conditions, such as tumors, injuries, or diseases affecting the brain, spinal cord, heart, blood vessels, joints, and other internal organs. MRI does not use radiation like computed tomography (CT) scans.

The somatosensory cortex is a part of the brain located in the postcentral gyrus of the parietal lobe, which is responsible for processing sensory information from the body. It receives and integrates tactile, proprioceptive, and thermoception inputs from the skin, muscles, joints, and internal organs, allowing us to perceive and interpret touch, pressure, pain, temperature, vibration, position, and movement of our body parts. The somatosensory cortex is organized in a map-like manner, known as the sensory homunculus, where each body part is represented according to its relative sensitivity and density of innervation. This organization allows for precise localization and discrimination of tactile stimuli across the body surface.

The motor cortex is a region in the frontal lobe of the brain that is responsible for controlling voluntary movements. It is involved in planning, initiating, and executing movements of the limbs, body, and face. The motor cortex contains neurons called Betz cells, which have large cell bodies and are responsible for transmitting signals to the spinal cord to activate muscles. Damage to the motor cortex can result in various movement disorders such as hemiplegia or paralysis on one side of the body.

Functional laterality, in a medical context, refers to the preferential use or performance of one side of the body over the other for specific functions. This is often demonstrated in hand dominance, where an individual may be right-handed or left-handed, meaning they primarily use their right or left hand for tasks such as writing, eating, or throwing.

However, functional laterality can also apply to other bodily functions and structures, including the eyes (ocular dominance), ears (auditory dominance), or legs. It's important to note that functional laterality is not a strict binary concept; some individuals may exhibit mixed dominance or no strong preference for one side over the other.

In clinical settings, assessing functional laterality can be useful in diagnosing and treating various neurological conditions, such as stroke or traumatic brain injury, where understanding any resulting lateralized impairments can inform rehabilitation strategies.

Complex partial epilepsy, also known as temporal lobe epilepsy or focal impaired awareness epilepsy, is a type of epilepsy characterized by recurrent, unprovoked seizures that originate in the temporal lobe or other localized areas of the brain. These seizures typically involve alterations in consciousness or awareness, and may include automatisms (involuntary, repetitive movements), such as lip smacking, fidgeting, or picking at clothes. Complex partial seizures can last from a few seconds to several minutes and may be followed by a post-ictal period of confusion or fatigue.

Complex partial epilepsy is often associated with structural abnormalities in the brain, such as hippocampal sclerosis, tumors, or malformations. It can also be caused by infectious or inflammatory processes, vascular disorders, or genetic factors. The diagnosis of complex partial epilepsy typically involves a thorough neurological evaluation, including a detailed history of seizure symptoms, neuroimaging studies (such as MRI or CT scans), and electroencephalography (EEG) to record brain activity during and between seizures.

Treatment for complex partial epilepsy usually involves medication therapy with antiepileptic drugs (AEDs). In some cases, surgery may be recommended if medications are not effective in controlling seizures or if there is a structural lesion that can be safely removed. Other treatment options may include dietary modifications, such as the ketogenic diet, or vagus nerve stimulation.

Frontal lobe epilepsy is a type of focal epilepsy, which means that the seizures originate from a specific area in the brain called the frontal lobe. The frontal lobe is located at the front part of the brain and is responsible for various functions such as motor function, problem-solving, decision making, emotional expression, and social behavior.

In frontal lobe epilepsy, seizures can be quite varied in their presentation, but they often occur during sleep or wakefulness and may include symptoms such as:

* Brief staring spells or automatisms (such as lip smacking, chewing, or fumbling movements)
* Sudden and frequent falls or drops
* Vocalizations or sounds
* Complex behaviors, such as agitation, aggression, or sexual arousal
* Auras or warning sensations before the seizure

Frontal lobe epilepsy can be difficult to diagnose due to the varied nature of the seizures and their occurrence during sleep. Diagnostic tests such as electroencephalogram (EEG) and imaging studies like magnetic resonance imaging (MRI) may be used to help confirm the diagnosis. Treatment typically involves medication, but in some cases, surgery may be recommended if medications are not effective or cause significant side effects.

A seizure is an uncontrolled, abnormal firing of neurons (brain cells) that can cause various symptoms such as convulsions, loss of consciousness, altered awareness, or changes in behavior. Seizures can be caused by a variety of factors including epilepsy, brain injury, infection, toxic substances, or genetic disorders. They can also occur without any identifiable cause, known as idiopathic seizures. Seizures are a medical emergency and require immediate attention.

The brain is the central organ of the nervous system, responsible for receiving and processing sensory information, regulating vital functions, and controlling behavior, movement, and cognition. It is divided into several distinct regions, each with specific functions:

1. Cerebrum: The largest part of the brain, responsible for higher cognitive functions such as thinking, learning, memory, language, and perception. It is divided into two hemispheres, each controlling the opposite side of the body.
2. Cerebellum: Located at the back of the brain, it is responsible for coordinating muscle movements, maintaining balance, and fine-tuning motor skills.
3. Brainstem: Connects the cerebrum and cerebellum to the spinal cord, controlling vital functions such as breathing, heart rate, and blood pressure. It also serves as a relay center for sensory information and motor commands between the brain and the rest of the body.
4. Diencephalon: A region that includes the thalamus (a major sensory relay station) and hypothalamus (regulates hormones, temperature, hunger, thirst, and sleep).
5. Limbic system: A group of structures involved in emotional processing, memory formation, and motivation, including the hippocampus, amygdala, and cingulate gyrus.

The brain is composed of billions of interconnected neurons that communicate through electrical and chemical signals. It is protected by the skull and surrounded by three layers of membranes called meninges, as well as cerebrospinal fluid that provides cushioning and nutrients.

Post-traumatic epilepsy (PTE) is a type of epilepsy that is caused by brain injury or trauma. The head injury can be either traumatic (such as from a car accident, fall, or physical assault) or non-traumatic (such as stroke, infection, or brain tumor).

In PTE, the first seizure occurs within one week to one year after the initial injury. The seizures may be immediate (within the first 24 hours of the injury) or delayed (occurring more than one week after the injury).

PTE is characterized by recurrent seizures that are caused by abnormal electrical activity in the brain. These seizures can vary in severity and frequency, and may cause a range of symptoms such as convulsions, loss of consciousness, and altered sensations or emotions.

The diagnosis of PTE is typically made based on the patient's history of head trauma, along with the results of an electroencephalogram (EEG) and neuroimaging studies such as MRI or CT scans. Treatment for PTE may include medication to control seizures, as well as surgery or other interventions in some cases.

Landau-Kleffner Syndrome (LKS) is a rare childhood neurological disorder characterized by the sudden or gradual development of an aphasia (language disturbance), which is often accompanied by various seizure types. It primarily affects children between the ages of 5 and 7, with normal language development followed by a regression.

The hallmark of LKS is the loss of the ability to understand spoken language (receptive aphasia) and, in some cases, the inability to speak (expressive aphasia). This language disorder may occur either suddenly or gradually, and it can sometimes be accompanied by various types of epileptic seizures.

The EEG (electroencephalogram), which measures electrical activity in the brain, often shows abnormalities during sleep stages in children with LKS. However, these abnormalities may not always correlate with the occurrence of seizures.

Although the exact cause of Landau-Kleffner Syndrome is unknown, it's believed to be related to an abnormality in the language-dominant hemisphere (usually the left) of the brain. Treatment typically involves anti-seizure medications and, in some cases, corticosteroids or other immunosuppressive therapies. Speech and language therapy are also crucial components of treatment to help children regain their communication skills.

MedlinePlus is not a medical term, but rather a consumer health website that provides high-quality, accurate, and reliable health information, written in easy-to-understand language. It is produced by the U.S. National Library of Medicine, the world's largest medical library, and is widely recognized as a trusted source of health information.

MedlinePlus offers information on various health topics, including conditions, diseases, tests, treatments, and wellness. It also provides access to drug information, medical dictionary, and encyclopedia, as well as links to clinical trials, medical news, and patient organizations. The website is available in both English and Spanish and can be accessed for free.

Intellectual disability (ID) is a term used when there are significant limitations in both intellectual functioning and adaptive behavior, which covers many everyday social and practical skills. This disability originates before the age of 18.

Intellectual functioning, also known as intelligence, refers to general mental capacity, such as learning, reasoning, problem-solving, and other cognitive skills. Adaptive behavior includes skills needed for day-to-day life, such as communication, self-care, social skills, safety judgement, and basic academic skills.

Intellectual disability is characterized by below-average intelligence or mental ability and a lack of skills necessary for day-to-day living. It can be mild, moderate, severe, or profound, depending on the degree of limitation in intellectual functioning and adaptive behavior.

It's important to note that people with intellectual disabilities have unique strengths and limitations, just like everyone else. With appropriate support and education, they can lead fulfilling lives and contribute to their communities in many ways.

"Facies" is a medical term that refers to the typical appearance of a person or part of the body, particularly the face, which may provide clues about their underlying medical condition or genetic background. A specific facies is often associated with certain syndromes or disorders. For example, a "downsyndrome facies" refers to the distinctive facial features commonly found in individuals with Down syndrome, such as a flattened nasal bridge, almond-shaped eyes, and an upward slant to the eyelids.

It's important to note that while facies can provide valuable diagnostic information, it should be used in conjunction with other clinical findings and genetic testing to make a definitive diagnosis. Additionally, facies should be described objectively and without judgment, as they are simply physical characteristics associated with certain medical conditions.

Sleep deprivation is a condition that occurs when an individual fails to get sufficient quality sleep or the recommended amount of sleep, typically 7-9 hours for adults. This can lead to various physical and mental health issues. It can be acute, lasting for one night or a few days, or chronic, persisting over a longer period.

The consequences of sleep deprivation include:

1. Fatigue and lack of energy
2. Difficulty concentrating or remembering things
3. Mood changes, such as irritability or depression
4. Weakened immune system
5. Increased appetite and potential weight gain
6. Higher risk of accidents due to decreased reaction time
7. Health problems like high blood pressure, diabetes, and heart disease over time

Sleep deprivation can be caused by various factors, including stress, shift work, sleep disorders like insomnia or sleep apnea, poor sleep hygiene, and certain medications. It's essential to address the underlying causes of sleep deprivation to ensure proper rest and overall well-being.

In the context of medical terminology, tablets refer to pharmaceutical dosage forms that contain various active ingredients. They are often manufactured in a solid, compressed form and can be administered orally. Tablets may come in different shapes, sizes, colors, and flavors, depending on their intended use and the manufacturer's specifications.

Some tablets are designed to disintegrate or dissolve quickly in the mouth, making them easier to swallow, while others are formulated to release their active ingredients slowly over time, allowing for extended drug delivery. These types of tablets are known as sustained-release or controlled-release tablets.

Tablets may contain a single active ingredient or a combination of several ingredients, depending on the intended therapeutic effect. They are typically manufactured using a variety of excipients, such as binders, fillers, and disintegrants, which help to hold the tablet together and ensure that it breaks down properly when ingested.

Overall, tablets are a convenient and widely used dosage form for administering medications, offering patients an easy-to-use and often palatable option for receiving their prescribed treatments.

Absence epilepsy is a type of epilepsy characterized by recurrent brief episodes of "absences," or staring spells, that can last from a few seconds to several minutes. These episodes are often accompanied by subtle body movements such as lip smacking or eyelid flutters. Absence epilepsy is most commonly diagnosed in children and adolescents, and it is more common in girls than boys.

The seizures in absence epilepsy are caused by abnormal electrical activity in the brain, specifically in a part of the brain called the cortex. These abnormal electrical discharges occur in a pattern that involves both sides of the brain simultaneously. This differs from other types of epilepsy, which may involve only one side of the brain or specific areas within a single hemisphere.

Absence seizures are typically brief and do not cause confusion or disorientation after they end. However, if they occur frequently, they can interfere with learning and social development. In some cases, absence epilepsy may be associated with other types of seizures, such as generalized tonic-clonic (grand mal) seizures or myoclonic jerks.

The diagnosis of absence epilepsy is usually made based on the characteristic symptoms and the results of an electroencephalogram (EEG), which can detect the abnormal electrical activity in the brain during a seizure. Treatment typically involves medication to control the seizures, such as ethosuximide or valproic acid. In some cases, a ketogenic diet may also be recommended as an alternative treatment option.

I'm sorry for any confusion, but "pamphlets" is not a medical term. It refers to a small paper booklet or leaflet that can be used to provide information on various topics, including non-medical subjects. If you have any questions about medical terminology or concepts, I'd be happy to help with those!

Neurology is a branch of medicine that deals with the study and treatment of diseases and disorders of the nervous system, which includes the brain, spinal cord, peripheral nerves, muscles, and autonomic nervous system. Neurologists are medical doctors who specialize in this field, diagnosing and treating conditions such as stroke, Alzheimer's disease, epilepsy, Parkinson's disease, multiple sclerosis, and various types of headaches and pain disorders. They use a variety of diagnostic tests, including imaging studies like MRI and CT scans, electrophysiological tests like EEG and EMG, and laboratory tests to evaluate nerve function and identify any underlying conditions or abnormalities. Treatment options may include medication, surgery, rehabilitation, or lifestyle modifications.

Benign Rolandic epilepsy or self-limited epilepsy with centrotemporal spikes (formerly benign childhood epilepsy with ... Benign Rolandic epilepsy. Retrieved August 8, 2008. Beaussart, Marc (December 1972). "Benign epilepsy of children with Rolandic ... Learning can remain unimpaired while a child is afflicted with Rolandic epilepsy. Benign epilepsy with centrotemporal spikes is ... August 2012). "Neuropsychological assessment of children with rolandic epilepsy: Executive functions". Epilepsy Behav. 24 (4): ...
ROR2 Rolandic epilepsy, mental retardation, and speech dyspraxia; 300643; SRPX2 Rothmund-Thomson syndrome; 268400; RECQL4 ... KRT9 Epilepsy, benign neonatal, type 2; 121201; KCNQ3 Epilepsy, benign, neonatal, type 1; 121200; KCNQ2 Epilepsy, female- ... CHRNA4 Epilepsy, nocturnal frontal lobe, 3; 605375; CHRNB2 Epilepsy, nocturnal frontal lobe, type 4; 610353; CHRNA2 Epilepsy, ... KCTD7 Epilepsy, pyridoxine-dependent; 266100; ALDH7A1 Epilepsy, severe myoclonic, of infancy; 607208; SCN1A Epilepsy, X-linked ...
"Neurosurgical management of intractable Rolandic epilepsy in children; role of resection in eloquen cortex". J Neurosurg ... His main clinical interests include the neurosurgical treatment of children with brain tumours and epilepsy. His research ... epilepsy surgery, and surgical education. In 2014, he was appointed as the 7th Editor-in-Chief of the Journal of Neurosurgery, ... and epilepsy. With his colleagues, he helped introduce digital camera technology to assist with mapping of intra-operative ...
2013). "Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes". Nat Genet. 45 (9): 1067-72. doi:10.1038/ng. ... Myers KA, Scheffer IE (2016). "GRIN2A-Related Speech Disorders and Epilepsy". GeneReviews. University of Washington, Seattle. ... Clinical features of GRIN-related disorders typically include intellectual disability and epilepsy along with other ...
This is the first gene to be linked with rolandic epilepsy. It has been found that children with Rolandic epilepsy have a ... Although Rolandic epilepsy (RE), which has been observed as autosomal dominant with high penetrance, develops around age 3 and ... The expression of ELP and the fourth sub-unit (ELP4) in particular is the cause of Rolandic epilepsy and possibly other ... In a study published in February 2009, researcher linked this gene to the most common form of human epilepsy, namely Rolandic ...
A duplication of the C16orf78 gene was associated with at least one case of Rolandic Epilepsy. C16orf78 has no known paralogs ... "16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy". Human Molecular Genetics. 23 (22): 6069- ...
Mutations in SRPX2 were linked in one 2006 study to a family with a form of Rolandic epilepsy with intellectual disability and ... "OMIM Entry - # 300643 - ROLANDIC EPILEPSY, MENTAL RETARDATION, AND SPEECH DYSPRAXIA, X-LINKED; RESDX". omim.org. Retrieved 2020 ... Additionally, no mutations in SRPX2 have been reported with Rolandic epilepsy since. In mice, mutations in SRPX2 lead to ... "Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas". BMC Genetics ...
16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy. Hum Mol Genet 23:6069-80 with Quednow, BB, ...
Also the Rolandic epilepsy was investigated with the MEG for the first time. For the localisation of motor, sensory, speech ... This led to the classification of two subtypes of patients with medial temporal lobe epilepsy, who have different distribution ... Research of the study group Baumgartner yielded new insights into temporal lobe epilepsy. By investigating 30 patients of this ... Benign focal epilepsy of childhood - A combined neuro¬electric and neuromagnetic study. In: C. Baumgartner, L. Deecke, G. ...
August 2019). "Heterozygous loss of function of NR4A2 is associated with intellectual deficiency, rolandic epilepsy, and ...
It is classified amongst benign idiopathic childhood focal epilepsies such as rolandic epilepsy and Panayiotopoulos syndrome. ... Idiopathic childhood occipital epilepsy of Gastaut (ICOE-G) is a pure but rare form of idiopathic occipital epilepsy that ... "Idiopathic Childhood Occipital Epilepsy of Gastaut: A Review and Differentiation From Migraine and Other Epilepsies". Journal ... Benign epilepsy of childhood with occipital spike and wave complexes. In: Andermann F, Lugaresi E, editors. Migraine and ...
Those with Rolandic seizures may be allowed to fly if they are seizure-free for at least four years. Children who have had a ... UK Epilepsy Action: Driving and Epilepsy, I've had a seizure. What should I do? Archived 2008-10-15 at the Wayback Machine UK ... Ben-Menachem E (2004). "Toward a more pragmatic view of driving and epilepsy". Epilepsy Curr. 4 (4): 133-4. doi:10.1111/j.1535- ... "Can you drive with epilepsy". 8 February 2016. "Factsheet 17 -- Epilepsy/seizures and driving" (PDF). NZ Transport Agency. ...
"2017 Revised Classification of Seizures". Epilepsy Foundation. "Types of Seizures". Epilepsy Foundation. Steven C. Schachter, ... This is due to the varying locations of the brain in which the seizures originate (e.g., Rolandic). A simple partial seizure ... "International League Against Epilepsy." 2008. Trescher, William H., and Ronald P. Lescher 2000, p. 1747. (Webarchive template ... The symptoms of these seizures can also be misconstrued as auras, especially for epilepsy patients with multiple types of ...
She has lived with benign rolandic epilepsy (BRE), a syndrome that caused her to have feelings of exclusion from others, ... about her battle with benign rolandic epilepsy. Her mission in writing the song was to say thank you to her primary school ...
March 1999). "Autosomal recessive rolandic epilepsy with paroxysmal exercise-induced dystonia and writer's cramp: delineation ... While PED can occur in isolation it was also noted that it occurs in association with epilepsy as well. In this study the ... A correlation between epilepsy and PED has been observed in several families across multiple generations, demonstrating an ... PED also has been associated with Parkinson's disease, epilepsy and migraines, although the exact relationship between these is ...
It is unclear if there are any benefits to clobazam over other seizure medications for children with Rolandic epilepsy or other ... "Clobazam". Epilepsy Ontario. 2020. Retrieved 2020-08-21. Larrieu JL, Lagueny A, Ferrer X, Julien J (December 1986). "[Epilepsy ... Clobazam is used for its anxiolytic effect, and as an adjunctive therapy in epilepsy. As an adjunctive therapy in epilepsy, it ... Clobazam is sometimes used for refractory epilepsies. However, long-term prophylactic treatment of epilepsy may have ...
Some examples of epilepsy syndromes include benign rolandic epilepsy (2.8 per 100,000), childhood absence epilepsy (0.8 per ... Benign centrotemporal lobe epilepsy of childhood or benign Rolandic epilepsy is an idiopathic localization-related epilepsy ... Catamenial epilepsy is the term denoting seizures linked to the menstrual cycle. Primary reading epilepsy is a reflex epilepsy ... Pyridoxine-dependent epilepsy Progressive myoclonic epilepsies define a group of symptomatic generalized epilepsies ...
Less serious examples are benign rolandic epilepsy (2.8 per 100,000), childhood absence epilepsy (0.8 per 100,000) and juvenile ... Wikiquote has quotations related to Epilepsy. "Epilepsy Basics: An Overview for Behavioral Health Providers". YouTube. Epilepsy ... Bromfield EB (2006). "Basic Mechanisms Underlying Seizures and Epilepsy". An Introduction to Epilepsy. American Epilepsy ... for instance benign rolandic epilepsy. Clinical syndromes in which epilepsy is not the main feature (e.g. Angelman syndrome) ...
Today, sulthiame is the drug of choice for benign focal epilepsies of childhood (such as benign rolandic epilepsy) in the ... Sultiame became established as a second-line drug for treatment of partial epilepsy in the 1960s and 1970s and was often used ... Koepp MJ, Patsalos PN, Sander JW (August 2002). "Sulthiame in adults with refractory epilepsy and learning disability: an open ... Doose H, Baier WK, Ernst JP, Tuxhorn I, Völzke E (October 1988). "Benign partial epilepsy--treatment with sulthiame". ...
... with rolandic epilepsy as their main representative, are probably linked due to a common, genetically determined, mild, and ... although siblings with Panayiotopoulos syndrome or Panayiotopoulos syndrome and rolandic epilepsy or, less common, ... rolandic) sulci. Patients with frontal spikes were significantly older than patients with spikes on rolandic, parieto-occipital ... early onset benign childhood occipital epilepsy, nocturnal childhood occipital epilepsy.[citation needed]The reason for this is ...
... and Rolandic epilepsy. Saggio sopra la vera struttura del cervello dell'uomo e degli animali e sopra le funzioni del sistema ... the Rolandic artery (central sulcal artery), the pre-Rolandic artery (precentral sulcal artery), the Rolandic operculum (post- ... A range of neuroanatomical and neurological entities are named after him: the Rolandic vein, ... central operculum), the Rolandic area (primary motor cortex), the substantia gelatinosa of Rolando, the fissure of Rolando ( ...
Henri Louis Roger Rolandic epilepsy - Luigi Rolando Rotor syndrome - Arturo Belleza Rotor Rubinstein-Taybi syndrome - Jack ...
... a DNA sequence benign Rolandic epilepsy, a syndrome BRE (gene), human gene Bloom-Richardson-Elston grading system for breast ...
For focal epilepsy, resective surgery is one of the mainstay treatment options for medication resistant epilepsy. Through the ... Ferrier and Horsley employed CSM to further grasp the structure and function of the pre-Rolandic and post-Rolandic areas, also ... Noachtar, Soheyl; Rémi, Jan (2009). "The role of EEG in epilepsy: A critical review". Epilepsy & Behavior. 15 (1): 22-33. doi: ... CSM is routinely utilized for patients with epilepsy in order to pin point the focal point of the seizures. It is used once ...
... epilepsy, rolandic MeSH C10.228.140.490.360.290 - epilepsy, temporal lobe MeSH C10.228.140.490.370 - epilepsy, benign neonatal ... epilepsy, frontal lobe MeSH C10.228.140.490.360.272 - epilepsy, partial, motor MeSH C10.228.140.490.360.275 - epilepsy, partial ... epilepsy MeSH C10.228.140.490.250 - epilepsies, myoclonic MeSH C10.228.140.490.250.300 - myoclonic epilepsy, juvenile MeSH ... epilepsy, absence MeSH C10.228.140.490.375.290 - epilepsy, tonic-clonic MeSH C10.228.140.490.375.760 - spasms, infantile MeSH ...
In the XX century, in the process of treating epilepsy, Wilder Penfield produced maps of the location of various functions ( ... including the Rolandic area. Phineas Gage became one of the first lesion case studies in 1848 when an explosion drove a large ...
When a routine EEG is normal and there is a high suspicion or need to confirm epilepsy, it may be repeated or performed with a ... Gastaut H (1952). "[Electrocorticographic study of the reactivity of rolandic rhythm]". Revue Neurologique. 87 (2): 176-182. ... An admission to an Epilepsy Monitoring Unit typically lasts several days but may last for a week or longer. While in the ... During (inpatient) epilepsy monitoring, a patient's typical seizure medications may be withdrawn. The digital EEG signal is ...
Benign Rolandic epilepsy or self-limited epilepsy with centrotemporal spikes (formerly benign childhood epilepsy with ... Benign Rolandic epilepsy. Retrieved August 8, 2008. Beaussart, Marc (December 1972). "Benign epilepsy of children with Rolandic ... Learning can remain unimpaired while a child is afflicted with Rolandic epilepsy. Benign epilepsy with centrotemporal spikes is ... August 2012). "Neuropsychological assessment of children with rolandic epilepsy: Executive functions". Epilepsy Behav. 24 (4): ...
epilepsy and seizures. Introduction. With an incidence of 1/2500, rolandic epilepsy (RE) or benign epilepsy with centrotemporal ... Background Rolandic epilepsy (RE) is the most common genetic childhood epilepsy, consisting of focal, nocturnal seizures and ... A subset of genomic alterations detected in rolandic epilepsies contains candidate or known epilepsy genes including GRIN2A and ... Rolandic epilepsy: an incidence study in Iceland. Epilepsia 1998;39:884-6.doi:10.1111/j.1528-1157.1998.tb01185.x ...
... is an essential component in the evaluation of epilepsy. The EEG provides important information about background EEG and ... Benign rolandic epilepsy. Patients with benign rolandic epilepsy are typically aged 3-10 years. They may present with a history ... Epilepsy syndromes. Epilepsy syndromes include symptomatic, cryogenic, and idiopathic epilepsy. Symptomatic epilepsy is defined ... Benign Partial Epilepsies. Two benign partial epilepsy syndromes of childhood have been well defined: (1) benign rolandic ...
Rolandic epilepsy (ER) corresponds to 15 - 25 percent of all childhood epilepsy prior to fifteen years of age, characterized by ... Palavras-chave : Rolandic epilepsy; Antiepileptic drugs; Cognition; Children. · resumo em Português · texto em Português · ... ZANINOTTO, Ana Luiza Costa e HAMAD, Ana Paula. Neurological and neuropsychological characteristics in rolandic epilepsy. Psicol ...
... Author: Lemke, Johannes R.; Lal, Dennis; Reinthaler, ... Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. DSpace Repository. Login ...
Benign Rolandic Epilepsy. Kids with benign rolandic epilepsy have seizures that involve twitching, numbness, or tingling of the ...
Objective: Rolandic epilepsy is a common genetic focal epilepsy of childhood characterized by centrotemporal sharp waves on ... N2 - Objective: Rolandic epilepsy is a common genetic focal epilepsy of childhood characterized by centrotemporal sharp waves ... AB - Objective: Rolandic epilepsy is a common genetic focal epilepsy of childhood characterized by centrotemporal sharp waves ... abstract = "Objective: Rolandic epilepsy is a common genetic focal epilepsy of childhood characterized by centrotemporal sharp ...
The epilepsy-aphasia spectrum is a group of conditions that have overlapping signs and symptoms. Explore symptoms, inheritance ... autosomal dominant rolandic epilepsy with speech dyspraxia (ADRESD), intermediate epilepsy-aphasia disorder (IEAD), atypical ... CECTS is at the mild end of the epilepsy-aphasia spectrum. Affected children have rolandic seizures; these seizures are ... Individuals with an epilepsy-aphasia spectrum disorder may have family members with a condition in the epilepsy-aphasia ...
... subunit genes contribute to the etiology of rolandic epilepsy (RE) or its atypical variants (ARE). METHODS: We performed exome ... Rare variants in γ-aminobutyric acid type A receptor genes in rolandic epilepsy and related syndromes. ... Epilepsy, Rolandic, European Continental Ancestry Group, Exome, Female, HEK293 Cells, Humans, Landau-Kleffner Syndrome, ... Rare variants in γ-aminobutyric acid type A receptor genes in rolandic epilepsy and related syndromes. ...
Benign Rolandic Epilepsy Kids with benign rolandic epilepsy have seizures that involve twitching, numbness, or tingling of the ... Temporal Lobe Epilepsy Kids with temporal lobe epilepsy have seizures that start in one of the temporal lobes of the brain. ... Epilepsy Epilepsy causes electrical signals in the brain to misfire, which can lead to multiple seizures. Anyone can get ... Intractable Epilepsy Intractable epilepsy is when a childs seizures cant be controlled by medicines. Doctors may recommend ...
Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. Nat Genet 2013; 45 (9) 1067-1072 ... Journal of Pediatric Epilepsy LinksClose Window References. Lemke JR, Lal D, Reinthaler EM , et al. ...
Epilepsy-aphasia spectrum ... seizures (epilepsy), and some have mild to severe intellectual disability. The ... rolandic ...
Epilepsy in children is a condition that causes seizures. It happens when brain cells experience uncontrolled electrical ... Rolandic epilepsy (self-limited epilepsy with centrotemporal spikes): Affecting an estimated 15% of children diagnosed with ... While epilepsy causes seizures, not all seizures are the result of epilepsy in children. To receive an epilepsy diagnosis, a ... What is epilepsy in children?. Epilepsy in children is a brain condition that causes seizures. The cells in your childs brain ...
Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4). Eur J Hum Genet. 2009 Sep ... Educational problems related to quantitative EEG changes in benign childhood epilepsy with centrotemporal spikes. Epilepsy ... Epileptic negative myoclonus as the presenting seizure type in rolandic epilepsy. Pediatr Neurol. 2009 Jul. 41(1):59-64. [QxMD ... Identification of Novel Genomic Risk Loci Shared Between Common Epilepsies and Psychiatric Disorders ...
Acting Out, Au Pairs, Rolandic Epilepsy - PediaCast 308. Posted by Dr. Mike on February 12, 2015. ... and benign rolandic epilepsy. TOPICS Measles & Vaccinations Breastfeeding […] ...
Since then, basic and clinical researchers in epilepsy have gathered together about every 14 years to assess where epilepsy ... In a foreword written for the second edition of Basic Mechanisms of the Epilepsies, published in 1983, Jasper reminded us that ... on the Epilepsies of the National Institutes of Health published the first edition of Basic Mechanisms of the Epilepsies. The ... Major Susceptibility Genes for Common Idiopathic Epilepsies: ELP4 in Rolandic Epilepsy and BRD2 in Juvenile Myoclonic Epilepsy ...
BRE(C) (BECTS) Benign Rolandic Epilepsy of Childhood / Benign Epilepsy with Centro-Tempro Spikes Focal or biphasic spikes in ... Can accompany BECTS/Rolandic Epilepsy, distinctive, focal in the central head region, may spread to T3 & T4. Usually biphasic ... Occipital epilepsy, usually in children. It is distinctive and has visual symptoms (hallucinations may be CP) and a favorable ... centro/Rolandic). Normal Variants - Subclinical Rhythmic Encepholographic Discharges of Adults (SREDA):. Looks like ictal ...
Benign epilepsy with centrotemporal spikes or rolandic epilepsy (RE) is the most common childhood epilepsy. The centrotemporal ... Quality of life of children with benign rolandic epilepsy. Pediatr Neurol 2006;35:240-5.doi:10.1016/j.pediatrneurol.2006.03.012 ... We waited a week and were then told they thought he had something called benign rolandic epilepsy. It is not a helpful name as ... Epilepsy is a common long-term condition affecting 0.5%-1% of children and often starts in childhood.5 Epilepsy is an umbrella ...
Benign neonatal epilepsy. *Benign Rolandic epilepsy. *Bicuculline. *Bifunctional peroxisomal enzyme deficiency. *Birth hypoxia ... Now I face the potential diagnosis of epilepsy without knowing if it was a result of the accident trauma or if the third ...
Benign childhood epilepsy syndromes. In benign childhood epilepsy with centro-temporal spikes (benign rolandic epilepsy), the ... USES OF EEG IN DIAGNOSIS OF EPILEPSY. EEG helps determine seizure type and epilepsy syndrome in patients with epilepsy, and ... EEG FINDINGS IN EPILEPSY SYNDROMES. Many of the epilepsy syndromes associated with specific EEG features present in early life ... Photosensitive epilepsy. Photosensitivity is found in about 5% of all epilepsies, usually IGE, but occurring also in ...
16p11.2 600 kb duplications confer risk for typical and atypical Rolandic epilepsy. Hum Mol Genet 2014, 23: 6069-6080 ... Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. Nature Genetics 2013; 45: 1067-72 ... DEPDC5 mutations in genetic focal epilepsies of childhood. Ann Neurol. 2014, 75: 788-792 ... KCNQ2 and KCNQ3 mutations contribute to different idiopathic epilepsy syndromes. Neurology 71, 177-83 2008 ...
He is being worked up for migraines, rolandic and or idiopathic epilepsy . My husband is hoping its a fluke he had a seizure ... Her diagnosis has changed from absence epilepsy to myoclonic epilepsy to finally earlier this year myoclonic absence epilepsy ... Just remember that many people live successfully with epilepsy, and if it is something like Rolandic he will be just fine. Our ... She has also been re-diagnosed as Myoclonic-Astatic Epilepsy, a developmental degenerative form of epilepsy if we cant get the ...
Racial/ethnic disparities in the treatment of epilepsy: what do we know? What do we need to know? Epilepsy & behavior : E&B, 9 ... Racial/ethnic disparities in the treatment of epilepsy: what do we know? What do we need to know? Epilepsy & behavior : E&B, 9 ... Assessment of adverse events and quality of life in epilepsy: design of a new community-based trial Epilepsy & behavior : E&B, ... Behavioral intervention as an add-on therapy in epilepsy: designing a clinical trial. Epilepsy & behavior : E&B, 25 4, 505-10 ...
Absence épileptique (Absence Epilepsy). *Épilepsie rolandique bénigne (ÉRB) à pointes centro-temporales (Benign Rolandic ... Les femmes et lépilepsie (Women and Epilepsy). *Les hormones et lépilepsie chez les femmes (Hormones and Epilepsy in Women) ... Faits épilepsie (Epilepsy Facts). *Feuillet de renseignements sur lépilepsie (Epilepsy Fact Sheet) ... Lépilepsie et la contraception (Epilepsy and Contraception). *Épilepsie et sexualité chez les femmes (Epilepsy and Sexual ...
A routine EEG had shown left central sharp waves during sleep, so the suspicion was Benign Rolandic Epilepsy (BRE). Since the ... Epilepsy Walk. Join the Neurodiagnostic community in the Walk to End Epilepsy. ... larry Interest Section, Members Only acute, ambulatory monitoring, autonomic testing, clinical EEG, epilepsy monitoring, ... EPILEPSY MONITORING. By Magdalena Warzecha, R. EEG/EP T., CLTM. As NDT professionals working in medical field, we are ...
AVC , Rolandic epilepsy and cognitive dysfunction, is it really a benign entity?. Abstract. Authors conclusions: children with ... rolandic epilepsy display a profile of pervasive cognitive difficulties. These results challenge current conceptions of this ... limitations of the study make necessary to assess with caution the magnitude of the cognitive dysfunction in rolandic epilepsy ... kind of epilepsy as a benign disease or of limited specific or localized cognitive effect. ...
  • Benign Rolandic epilepsy or self-limited epilepsy with centrotemporal spikes (formerly benign childhood epilepsy with centrotemporal spikes (BECTS)) is the most common epilepsy syndrome in childhood. (wikipedia.org)
  • The conditions in the epilepsy-aphasia spectrum, which all begin in childhood, include Landau-Kleffner syndrome (LKS), epileptic encephalopathy with continuous spike-and-wave during sleep syndrome (ECSWS), autosomal dominant rolandic epilepsy with speech dyspraxia (ADRESD), intermediate epilepsy-aphasia disorder (IEAD), atypical childhood epilepsy with centrotemporal spikes (ACECTS), and childhood epilepsy with centrotemporal spikes (CECTS). (medlineplus.gov)
  • Atypical features in benign epilepsy of childhood with centrotemporal spikes (BECTS) are not uncommon. (elsevierpure.com)
  • Self-limited epilepsy with centrotemporal spikes (SeLECTS) is the new name for the previous epilepsy syndrome of benign epilepsy with centrotemporal spikes. (medlink.com)
  • Thus, the new term "self-limited epilepsy with centrotemporal spikes" (SeLECTS) was proposed for this epilepsy syndrome. (medlink.com)
  • Sleep related hypermotor epilepsy (SHE), benign partial epilepsy with centrotemporal spikes or benign rolandic epilepsy (BECTS), and Panayiotopoulos Syndrome (PS) are three of the most frequently implicated epilepsies occurring during the sleep state. (elsevierpure.com)
  • The seizures, sometimes referred to as sylvian seizures, start around the central sulcus of the brain (also called the centrotemporal area, located around the Rolandic fissure, after Luigi Rolando). (wikipedia.org)
  • The cardinal features of Rolandic epilepsy are infrequent, often single, focal seizures consisting of: a. unilateral facial sensorimotor symptoms (30% of patients) b. oropharyngolaryngeal manifestations (53% of patients) c. speech arrest (40% of patients), and d. hypersalivation (30% of patients) Hemifacial sensorimotor seizures are often entirely localised in the lower lip or spread to the ipsilateral hand. (wikipedia.org)
  • Consciousness and recollection are fully retained in more than half (58%) of Rolandic seizures. (wikipedia.org)
  • Duration and circadian distribution: Rolandic seizures are usually brief, lasting for 1-3 minutes. (wikipedia.org)
  • Other seizure types: Despite prominent hypersalivation, focal seizures with primarily autonomic manifestations (autonomic seizures) are not considered part of the core clinical syndrome of Rolandic epilepsy. (wikipedia.org)
  • However, some children may present with independent autonomic seizures or seizures with mixed Rolandic-autonomic manifestations including emesis as in Panayiotopoulos syndrome. (wikipedia.org)
  • Background Rolandic epilepsy (RE) is the most common genetic childhood epilepsy, consisting of focal, nocturnal seizures and frequent neurodevelopmental impairments in speech, language, literacy and attention. (bmj.com)
  • Symptomatic epilepsy is defined as seizures resulting from an identifiable cerebral disorder. (medscape.com)
  • Cryptogenic epilepsy consists of seizures that occur without an identifiable cause in a patient with cognitive impairment or with neurologic deficits (eg, Lennox-Gastaut syndrome (LGS), infantile spasms [see the first image below], and myoclonic astatic epilepsy of Doose. (medscape.com)
  • Rolandic epilepsy (ER) corresponds to 15 - 25 percent of all childhood epilepsy prior to fifteen years of age, characterized by partial or generalized seizures, which typically occur during sleep or waking hours. (bvsalud.org)
  • Kids with benign rolandic epilepsy have seizures that involve twitching, numbness, or tingling of the face or tongue. (childrensdayton.org)
  • Many people with conditions in this spectrum develop recurrent seizures (epilepsy), and some have mild to severe intellectual disability. (medlineplus.gov)
  • Epilepsy in children is a condition that causes seizures. (clevelandclinic.org)
  • While epilepsy causes seizures, not all seizures are the result of epilepsy in children. (clevelandclinic.org)
  • Affecting an estimated 15% of children diagnosed with epilepsy, Rolandic epilepsy seizures happen when falling asleep or waking up. (clevelandclinic.org)
  • Common during puberty, myoclonic epilepsy seizures cause uncontrolled muscle movements like twitching and jerking their arms around. (clevelandclinic.org)
  • Seizures are the main symptom of epilepsy in children. (clevelandclinic.org)
  • Epilepsy-specific quality of life is not determined solely by seizures, but rather by factors such as a child's learning, mental health, sleep and social support. (bmj.com)
  • Differences in paracingulate connectivity associated with epileptiform discharges and uncontrolled seizures in genetic generalized epilepsy. (uc.edu)
  • Comparisons of childhood trauma, alexithymia, and defensive styles in patients with psychogenic non-epileptic seizures vs. epilepsy: Implications for the etiology of conversion disorder. (uc.edu)
  • Neurologists have recently stressed the importance of quickly finding an effective treatment in childhood epilepsy because children have the best chance of recovering and avoiding long term impairment (learning difficulty, etc.) if seizures are controlled early. (oregonstate.edu)
  • Seizures involving the rolandic region of the brain are characteristic of this type of epilepsy. (medigac.com)
  • In cases when the onset of seizures is preceded by a febrile illness, these rare conditions are referred to as FIRES (Febrile Infection-Related Epilepsy Syndrome). (epilepsygenetics.net)
  • Sleep-related epilepsy is nocturnal seizures that manifest solely during the sleep state. (elsevierpure.com)
  • Epilepsy is a chronic disease of the brain characterised by an enduring predisposition to generate seizures, unprovoked by any immediate central nervous system insult, and by the neurobiological, cognitive, psychological, and social consequences of seizure recurrences. (medanta.org)
  • Recurrent seizures are the most common symptom of epilepsy, however there are other signs and symptoms that may indicate epilepsy. (medanta.org)
  • Kids with juvenile myoclonic epilepsy have myoclonic seizures that usually begin during the teen years. (kidshealth.org)
  • Different types of seizures can happen in juvenile myoclonic (my-uh-KLON-ik) epilepsy. (kidshealth.org)
  • Seizures in juvenile myoclonic epilepsy typically happen within 30 minutes of waking up in the morning or after a nap. (kidshealth.org)
  • People with epilepsy have repeated seizures . (kidshealth.org)
  • Often, kids with epilepsy have both generalized seizures and focal seizures. (kidshealth.org)
  • Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate seizures and by the neurobiologic, cognitive, psychological, and social consequences of this condition. (clinicalgate.com)
  • Thus, the occurrence of a single seizure or of febrile seizures does not necessarily imply the diagnosis of epilepsy. (clinicalgate.com)
  • Seizure disorder is a general term that is usually used to include any one of several disorders including epilepsy, febrile seizures, and possibly single seizures and seizures secondary to metabolic, infectious, or other etiologies (e.g., hypocalcemia, meningitis). (clinicalgate.com)
  • Psychological trauma, somatization, dissociation, and psychiatric comorbidities in patients with psychogenic nonepileptic seizures compared with those in patients with intractable partial epilepsy. (epilepsygroup.com)
  • Focal or biphasic spikes in the left or right Rolandic head regions (C3, C4, T3, or T4) independently during drowsiness. (studystack.com)
  • The childhood epilepsies traditionally referred to as Benign Rolandic Epilepsy (BRE) or benign epilepsy with centro-temporal spikes (BECTS) have had various names in the past, which reflects somewhat the difficulties of fully putting this group of seizure disorders into clear categories. (epilepsygenetics.net)
  • OBJECTIVE: To test whether mutations in γ-aminobutyric acid type A receptor (GABAA -R) subunit genes contribute to the etiology of rolandic epilepsy (RE) or its atypical variants (ARE). (ox.ac.uk)
  • 16p11.2 600 kb duplications confer risk for typical and atypical Rolandic epilepsy. (ukgm.de)
  • While most presentations are relatively mild and self-limited childhood epilepsies, a sizeable fraction of these non-lesional focal epilepsies have an atypical course. (epilepsygenetics.net)
  • A recent publication examined the genetic basis of self-limited focal epilepsies of childhood and found interesting new candidate genes in atypical presentations. (epilepsygenetics.net)
  • Neurologic examination and imaging in the essential idiopathic, typically genetic, epilepsies are usually normal. (medscape.com)
  • Normal background suggests primary epilepsy (ie, idiopathic or possibly genetic epilepsy). (medscape.com)
  • Epilepsy syndromes include symptomatic, cryogenic, and idiopathic epilepsy. (medscape.com)
  • Electroencephalogram demonstrating polyspike and wave discharges, which can be seen in idiopathic generalized epilepsy. (medscape.com)
  • Electroencephalogram demonstrating a run of generalized polyspikes, which are more left predominant and can be seen in idiopathic generalized epilepsies. (medscape.com)
  • This week, Dr. Monica Aleman presented an overview at the Platinum Summit in San Antonio of Juvenile Idiopathic Epilepsy (JIE) in Egyptian Arabian foals-an epileptic syndrome similar to one found in infants. (farms.com)
  • More than half of epilepsy cases are idiopathic, meaning there's no clear cause. (kidshealth.org)
  • Idiopathic epilepsy is an epilepsy syndrome that is genetic or presumed genetic and in which there is no underlying disorder affecting development or other neurologic function (e.g., petit mal epilepsy). (clinicalgate.com)
  • Electroencephalogram demonstrating polyspike and wave discharges seen in juvenile myoclonic epilepsy. (medscape.com)
  • Juvenile myoclonic epilepsy (or JME for short) is a common type of epilepsy that usually begins in teenage years (12-18 years old). (childhoodepilepsy.org)
  • This kind of seizure is the most common type in juvenile myoclonic epilepsy, and is the hallmark of this condition. (kidshealth.org)
  • The cause of juvenile myoclonic epilepsy isn't known, but it tends to run in families. (kidshealth.org)
  • How Is Juvenile Myoclonic Epilepsy Diagnosed? (kidshealth.org)
  • How Is Juvenile Myoclonic Epilepsy Treated? (kidshealth.org)
  • Juvenile myoclonic epilepsy is a lifelong condition. (kidshealth.org)
  • Elevated impulsivity is a key component of attention-deficit hyperactivity disorder (ADHD), bipolar disorder and juvenile myoclonic epilepsy (JME). (bvsalud.org)
  • EEG characteristics of these specific electroclinical epilepsy syndromes are discussed in this article. (medscape.com)
  • Rare variants in γ-aminobutyric acid type A receptor genes in rolandic epilepsy and related syndromes. (ox.ac.uk)
  • They can be found in a number of epilepsy syndromes, each with its own set of symptoms. (medigac.com)
  • In the present review, we aim to discuss the predominance of sleep-related epilepsy during NREM, established familial links to the pathogenesis of SHE, BECTS and PS, and highlight the present available pharmacotherapy options. (elsevierpure.com)
  • Our research explores the genetics of childhood epilepsy in order to improve the outlook for both diagnosis and treatment. (childhoodepilepsy.org)
  • Quite a lot has happened since then in epilepsy genetics, including the discovery of at least twenty additional genes, initial clinical trials, and large-scale studies such as our Epi25 initiative. (epilepsygenetics.net)
  • The genetics of the rolandic epilepsies and the related epilepsy-aphasia spectrum are tightly linked to GRIN2A , the most prominent gene in this group of conditions. (epilepsygenetics.net)
  • Childhood epilepsies include some of the simplest as well as the most difficult seizure types to treat. (childhoodepilepsy.org)
  • Chilhoodepilepsy.org is the website for Pal Neuro Lab at King's College London, where you can find out what studies we are working on, as well as reliable information for families about the different childhood epilepsies that we study. (childhoodepilepsy.org)
  • Infantile spasms are a severe type of epilepsy that affects infants when they fall asleep or wake up. (clevelandclinic.org)
  • The age when epilepsy in children starts varies based on what type of epilepsy your child has. (clevelandclinic.org)
  • It is an effective treatment for many epilepsy types, such as Jaron's Doose Syndrome, and can be effective for epilepsy with an unknown cause, such as Nora's. (oregonstate.edu)
  • Lennox-Gastaut syndrome (LGS) is a severe form of epilepsy that usually manifests in early childhood or infancy. (medigac.com)
  • Dravet syndrome is a rare, drug-resistant epilepsy that strikes an otherwise healthy infant in the first year of life. (medigac.com)
  • It was first reported in the 1950s and is now recognized as the most frequent epilepsy syndrome in children between the ages of 4 and 13 years. (medlink.com)
  • The term "benign" was applied to this syndrome to differentiate it from other sinister causes for focal epilepsies. (medlink.com)
  • Kids with Down syndrome , autism , and some metabolic disorders also may have epilepsy. (kidshealth.org)
  • In general, seizure type is the primary determinant of the type of medications the patient is likely to respond to, and the epilepsy syndrome determines the type of prognosis one could expect. (clinicalgate.com)
  • An epileptic encephalopathy is an epilepsy syndrome in which the severe EEG abnormality is thought to result in cognitive and other impairments in the patient. (clinicalgate.com)
  • Symptomatic epilepsy is an epilepsy syndrome caused by an underlying brain disorder (e.g., epilepsy secondary to tuberous sclerosis). (clinicalgate.com)
  • A cryptogenic epilepsy (also termed presumed symptomatic epilepsy ) is an epilepsy syndrome in which there is a presumed underlying brain disorder causing the epilepsy and affecting neurologic function, but the underlying disorder is not known. (clinicalgate.com)
  • What are the types of epilepsy in children? (clevelandclinic.org)
  • There are several types of epilepsy in children. (clevelandclinic.org)
  • Some types of epilepsy also respond particularly well to the diet, so the diet should be the first choice of treatment in those cases. (oregonstate.edu)
  • Many types of epilepsy only occur in childhood, often starting and finishing before 16 years of age. (childhoodepilepsy.org)
  • There are treatments for many types of epilepsy (EP-eh-lep-see). (kidshealth.org)
  • Some types of epilepsy run in families. (kidshealth.org)
  • Since then, basic and clinical researchers in epilepsy have gathered together about every 14 years to assess where epilepsy research has been, what it has accomplished, and where it should go. (nih.gov)
  • These wide ranges can be explained partly by diverse case selection and differences in clinical requirements for diagnosis of epilepsy in population studies of EEG specificity and sensitivity. (bmj.com)
  • Secondly, correlation between different EEG patterns and epilepsy varies, and only IED are associated with seizure disorders at a sufficiently high rate to be of clinical use. (bmj.com)
  • Some types of epileptiform phenomena-3 per second spike wave discharge, hypsarrhythmia, and generalised photoparoxysmal response-are strongly correlated with clinical epilepsy, whereas focal sharp waves in centro-temporal or occipital regions have moderate association with clinically active epilepsy. (bmj.com)
  • Bioequivalence Between Generic and Branded Lamotrigine in People With Epilepsy: The EQUIGEN Randomized Clinical Trial. (uc.edu)
  • Our epilepsy research is aimed at understanding the basic level of cause and mechanism, as well as the clinical level of symptom management. (childhoodepilepsy.org)
  • The clinical diagnosis of epilepsy usually requires the occurrence of at least 1 unprovoked epileptic seizure with either a second such seizure or enough EEG and clinical information to convincingly demonstrate an enduring predisposition to develop recurrences. (clinicalgate.com)
  • Absence epilepsy causes short moments when your child experiences confusion and stares off into the distance. (clevelandclinic.org)
  • During an absence epilepsy seizure, your child won't be able to respond if you talk to them. (clevelandclinic.org)
  • EEG continues to play a central role in diagnosis and management of patients with seizure disorders-in conjunction with the now remarkable variety of other diagnostic techniques developed over the last 30 or so years-because it is a convenient and relatively inexpensive way to demonstrate the physiological manifestations of abnormal cortical excitability that underlie epilepsy. (bmj.com)
  • The Northeast Regional Epilepsy Group doctors work steadily every year to advance knowledge of epilepsy diagnosis and treatment and other seizure disorders (e.g. psychogenic non-epileptic seizires). (epilepsygroup.com)
  • In addition, our doctors' research and published articles on epilepsy and seizure disorders in peer reviewed journals can also be found below. (epilepsygroup.com)
  • In the same year, Loiseau and colleagues presented an electroclinical series of 122 children with what they called "a particular form of epilepsy in childhood," stressing its benign character. (medlink.com)
  • Rolandic epilepsy is a common form of epilepsy in children which occurs primarily during sleep. (gesundheitsindustrie-bw.de)
  • Rolandic epilepsy and cognitive dysfunction, is it really a benign entity? (evidenciasenpediatria.es)
  • although the limitations of the study make necessary to assess with caution the magnitude of the cognitive dysfunction in rolandic epilepsy, it seems clear that this association exists. (evidenciasenpediatria.es)
  • This study provides, for the first time, evidence of a noncoding genomic variant contributing to the etiology of a common human epilepsy via a posttranscriptional regulatory mechanism. (elsevierpure.com)
  • In the last several decades, sleep-related epilepsy has drawn considerable attention among epileptologists and neuroscientists in the interest of new paradigms of the disease etiology, pathogenesis and management. (elsevierpure.com)
  • It is crucial to recognise that a normal EEG does not exclude epilepsy, as around 10% of patients with epilepsy never show epileptiform discharges. (bmj.com)
  • Short sounds played during sleep can partially suppress the neuronal discharges characteristic of epilepsy. (gesundheitsindustrie-bw.de)
  • Generic-to-generic lamotrigine switches in people with epilepsy: the randomised controlled EQUIGEN trial. (uc.edu)
  • Nearly 80% of people with epilepsy live in low- and middle-income countries. (medanta.org)
  • The risk of premature death in people with epilepsy is up to three times higher than in the general population. (medanta.org)
  • INTRODUCTION: The prevalence of mental health symptoms in people with epilepsy (PWE) is elevated compared with that of the general population. (bvsalud.org)
  • Further, this disorder resembles some inherited epileptic disorders in children such as Rolandic epilepsy in which children also outgrow epilepsy as they mature. (farms.com)
  • Abnormalities of background cerebral rhythms, focal slow activity or regional attenuation are much less specific than epileptiform activity, although they can indicate localised structural pathology underlying the seizure disorder, or diffuse cortical dysfunction as in symptomatic generalised epilepsies. (bmj.com)
  • Hypothalamic-pituitary-adrenocortical axis dysfunction in epilepsy. (uc.edu)
  • However, interictal background EEG frequencies that are slower than normal for age usually suggest a symptomatic epilepsy (ie, epilepsy secondary to brain insult). (medscape.com)
  • Its potential applications in epilepsy rapidly became clear, when Gibbs and colleagues in Boston demonstrated 3 per second spike wave discharge in what was then termed petit mal epilepsy. (bmj.com)
  • Does the Ketogenic Diet for Epilepsy Work? (oregonstate.edu)
  • Our families tried the ketogenic diet to treat our children's epilepsies because medications were not working, and we stuck with it because the diet worked. (oregonstate.edu)
  • Five patients with RE carried a rare CNV that disrupted genes associated with other epilepsies ( KCTD7 , ARHGEF15 , CACNA2D1, GRIN2A and ARHGEF4 ), and 17 cases carried CNVs that disrupted genes associated with other neurological conditions or that are involved in neuronal signalling/development. (bmj.com)
  • Variants (also known as mutations) in the GRIN2A gene can cause conditions in the epilepsy-aphasia spectrum. (medlineplus.gov)
  • As a parent, you have choices about your child's epilepsy treatment. (oregonstate.edu)
  • Therefore, it is important to be aware of this when considering a child's epilepsy diagnosis. (childhoodepilepsy.org)
  • The Rolandic (centrotemporal) region is named after Luigi Rolando (1773-1831), an Italian anatomist known for his pioneer research in localization of function in the human brain. (medlink.com)
  • You might hear your child's healthcare provider refer to their condition as pediatric epilepsy or seizure disorder. (clevelandclinic.org)
  • We were unable to identify genetic causes for FIRES, but we found interesting candidate genes and demonstrated that the genetic architecture of FIRES is substantially different from what we see in other genetic epilepsies. (epilepsygenetics.net)
  • Antiepileptic drugs, as well as other non-pharmacological epilepsy interventions can all affect sleep quality. (bmj.com)
  • Uncontrolled electrical activity in your child's brain causes epilepsy in children. (clevelandclinic.org)
  • These results challenge current conceptions of this kind of epilepsy as a benign disease or of limited specific or localized cognitive effect. (evidenciasenpediatria.es)
  • Basically what I know from the crash course I've had over the last two days is that if you had to go to the epilepsy store and buy a kind of epilepsy for your kid, this one is the one you should get. (lookydaddy.com)
  • The kind of epilepsy that somone has depends on the seizure type . (kidshealth.org)
  • Temporal sampling is also limited, and the relatively short duration of routine interictal EEG recording is one reason why patients with epilepsy may not show interictal epileptiform discharge (IED) in the first EEG study. (bmj.com)
  • Parents and children are key team players in dietary treatment for epilepsy. (oregonstate.edu)
  • Surgical treatment for epilepsy remains underutilized, due, in part, to misconceptions about this alternative therapy. (medanta.org)
  • To receive an epilepsy diagnosis, a healthcare provider will examine whether your child has more than one seizure that isn't caused by an underlying medical condition. (clevelandclinic.org)
  • Table 1 lists the areas in epilepsy diagnosis and management for which interictal and ictal EEG are useful, strongly so in some, but in a more limited way in others. (bmj.com)
  • Epileptiform activity is specific, but not sensitive, for diagnosis of epilepsy as the cause of a transient loss of consciousness or other paroxysmal event that is clinically likely to be epilepsy. (bmj.com)
  • The epilepsy-aphasia spectrum is a group of conditions that have overlapping signs and symptoms. (medlineplus.gov)
  • Another feature of epilepsy-aphasia spectrum disorders is certain patterns of abnormal electrical activity in the brain, which are detected by a test called an electroencephalogram (EEG). (medlineplus.gov)
  • CECTS is at the mild end of the epilepsy-aphasia spectrum. (medlineplus.gov)
  • The other conditions in the epilepsy-aphasia spectrum are less common and fall in the middle of the spectrum. (medlineplus.gov)
  • The prevalence of the epilepsy-aphasia spectrum is unknown. (medlineplus.gov)
  • Surgery - In some cases of epilepsy, surgery is indicated where the epileptic foci can be removed or structurally altered so that the need of medicine can be decreased or sometimes stopped altogether. (medanta.org)
  • These symptoms can negatively impact epilepsy management and patient outcomes but can be treated once recognised. (bvsalud.org)
  • Unfortunately, mental health symptoms are rarely addressed in epilepsy services due to time constraints, lack of resources and communication between psychological and medical professionals. (bvsalud.org)
  • The most prevalent type of infantile epilepsy is benign rolandic epilepsy (BRE). (medigac.com)

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