AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth CareGeographicals
EpendymomaInfratentorial NeoplasmsSpinal Cord NeoplasmsSupratentorial NeoplasmsBrain NeoplasmsCerebral Ventricle NeoplasmsCentral Nervous System NeoplasmsCauda EquinaSiderosisSacrococcygeal RegionNeurosurgical ProceduresRadiotherapy, ConformalMedulloblastomaFourth VentricleGlioma, SubependymalEpendymaAraliaceaeGliomaHealth Records, PersonalCellular PhoneMobile ApplicationsHospitals, UniversityPatient Access to RecordsElectronic Health RecordsAsparaginasePrecursor Cell Lymphoblastic Leukemia-LymphomaBostonCombined Modality TherapySpinal Cord DiseasesLow Back PainSpinal NeoplasmsKarnofsky Performance StatusCreatinineTreatment OutcomeBone MarrowCarboplatinBaltimoreMarylandResearchPathology Department, HospitalSpinal Cord CompressionRetrospective Studies
Ependymoma
Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
Infratentorial Neoplasms
Intracranial tumors originating in the region of the brain inferior to the tentorium cerebelli, which contains the cerebellum, fourth ventricle, cerebellopontine angle, brain stem, and related structures. Primary tumors of this region are more frequent in children, and may present with ATAXIA; CRANIAL NERVE DISEASES; vomiting; HEADACHE; HYDROCEPHALUS; or other signs of neurologic dysfunction. Relatively frequent histologic subtypes include TERATOMA; MEDULLOBLASTOMA; GLIOBLASTOMA; ASTROCYTOMA; EPENDYMOMA; CRANIOPHARYNGIOMA; and choroid plexus papilloma (PAPILLOMA, CHOROID PLEXUS).
Spinal Cord Neoplasms
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Supratentorial Neoplasms
Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Cerebral Ventricle Neoplasms
Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.
Central Nervous System Neoplasms
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
Cauda Equina
The lower part of the SPINAL CORD consisting of the lumbar, sacral, and coccygeal nerve roots.
Siderosis
A form of pneumoconiosis resulting from inhalation of iron in the mining dust or welding fumes.
Sacrococcygeal Region
The body region between (and flanking) the SACRUM and COCCYX.
Neurosurgical Procedures
Surgery performed on the nervous system or its parts.
Radiotherapy, Conformal
Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.
Medulloblastoma
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
Fourth Ventricle
An irregularly shaped cavity in the RHOMBENCEPHALON, located between the MEDULLA OBLONGATA; the PONS; and the isthmus in front, and the CEREBELLUM behind. It is continuous with the central canal of the cord below and with the CEREBRAL AQUEDUCT above, and through its lateral and median apertures it communicates with the SUBARACHNOID SPACE.
Glioma, Subependymal
Rare, slow-growing, benign intraventricular tumors, often asymptomatic and discovered incidentally. The tumors are classified histologically as ependymomas and demonstrate a proliferation of subependymal fibrillary astrocytes among the ependymal tumor cells. (From Clin Neurol Neurosurg 1997 Feb;99(1):17-22)
Ependyma
A thin membrane that lines the CEREBRAL VENTRICLES and the central canal of the SPINAL CORD.
Araliaceae
The ginseng plant family of the order Apiales, subclass Rosidae, class Magnoliopsida. Leaves are generally alternate, large, and compound. Flowers are five-parted and arranged in compound flat-topped umbels. The fruit is a berry or (rarely) a drupe (a one-seeded fruit). It is well known for plant preparations used as adaptogens (immune support and anti-fatigue).
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Health Records, Personal
Longitudinal patient-maintained records of individual health history and tools that allow individual control of access.
Cellular Phone
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Mobile Applications
Computer programs or software installed on mobile electronic devices which support a wide range of functions and uses which include television, telephone, video, music, word processing, and Internet service.
Hospitals, University
Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.
Patient Access to Records
The freedom of patients to review their own medical, genetic, or other health-related records.
Electronic Health Records
Media that facilitate transportability of pertinent information concerning patient's illness across varied providers and geographic locations. Some versions include direct linkages to online consumer health information that is relevant to the health conditions and treatments related to a specific patient.
Asparaginase
A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
Boston
Combined Modality Therapy
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Spinal Cord Diseases
Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.
Low Back Pain
Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.
Spinal Neoplasms
Karnofsky Performance Status
A performance measure for rating the ability of a person to perform usual activities, evaluating a patient's progress after a therapeutic procedure, and determining a patient's suitability for therapy. It is used most commonly in the prognosis of cancer therapy, usually after chemotherapy and customarily administered before and after therapy. It was named for Dr. David A. Karnofsky, an American specialist in cancer chemotherapy.
Creatinine
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Carboplatin
An organoplatinum compound that possesses antineoplastic activity.
Baltimore
Maryland
Research
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Pathology Department, Hospital
Hospital department which administers and provides pathology services.
Spinal Cord Compression
Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Extraneural metastasizing ependymoma of the spinal cord. (1/337)

This paper reports a case of the rare entity of an extraneural metastasizing ependymoma of the spinal cord. The tumor which arose in the conus medullaris and in the cauda equina was first diagnosed in 1956 when a thoracolumbar myeloresection was performed. At autopsy, 40 years after the primary diagnosis, a massive local tumor recurrence with extraneural metastases in the lungs, the pleura, the liver, and the thoracal and abdominal lymph nodes were found. Immunohistochemical stains of the extraneural metastases showed a strong cytoplasmatic expression of glial fibrillary acidic protein (GFAP). Neither the primary tumor nor its metastases showed any of the conventional morphological criteria of malignancy. Reviewing the literature we discuss the possible mechanism of extraneural tumor spread and the incidence of metastases with regard to the tumor type.  (+info)

Familial gliomas : a case report. (2/337)

Two non-twin brothers were found to have intracranial malignant neoplasms. The age of presentation was third and fourth decade but the onset was simultaneous, at the same time. Diagnosis in each of them was made by computed tomography and confirmed by histopathology. Elder among them had cellular ependymoma and the younger had oligodendroglioma. Both the brothers received radiotherapy post operatively and were surviving asymptomatically without any neurological deficit, leading active life as police constable, 12 months after surgical treatment.  (+info)

Molecular genetic analysis of ependymal tumors. NF2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas. (3/337)

Ependymal tumors are heterogeneous with regard to morphology, localization, age at first clinical manifestation, and prognosis. Several molecular alterations have been reported in these tumors, including allelic losses on chromosomes 10, 17, and 22 and mutations in the NF2 gene. However, in contrast to astrocytic gliomas, no consistent molecular alterations have been associated with distinct types of ependymal tumors. To evaluate whether morphological subsets of ependymomas are characterized by specific genetic lesions, we analyzed a series of 62 ependymal tumors, including myxopapillary ependymomas, subependymomas, ependymomas, and anaplastic ependymomas, for allelic losses on chromosome arms 10q and 22q and mutations in the PTEN and NF2 genes. Allelic losses on 10q and 22q were detected in 5 of 56 and 12 of 54 tumors, respectively. Six ependymomas carried somatic NF2 mutations, whereas no mutations were detected in the PTEN gene. All six of the NF2 mutations occurred in ependymomas of WHO grade II and were exclusively observed in tumors with a spinal localization (P = 0.0063). These findings suggest that a considerable fraction of spinal ependymomas are associated with molecular events involving chromosome 22 and that mutations in the NF2 gene may be of primary importance for their genesis. Furthermore, our data suggest that the more favorable clinical course of spinal ependymomas may relate to a distinct pattern of genetic alterations different from that of intracerebral ependymomas.  (+info)

Association of lower cranial nerve schwannoma with spinal ependymoma in ? NF2. (4/337)

A 15 year old male, who had earlier been operated for intraspinal intramedullary ependymoma, subsequently developed a right cerebello pontine (CP) angle mass. A diagnosis of right CP angle ependymoma was considered, in view of established histology of previously operated spinal lesion. Histopathological examination of the well defined extra-axial mass, which was attached with ninth cranial nerve, however revealed a schwannoma. A diagnosis of Neurofibromatosis-2 (NF2) is strongly suspected, because of well established fact, that the spinal ependymomas may have association with lower cranial nerve schwannomas in NF2. Cranial and spinal MRI screening for early diagnosis of associated, asymptomatic lesions, in suspected cases of NF2, particularly in children, is recommended.  (+info)

Tumour type and size are high risk factors for the syndrome of "cerebellar" mutism and subsequent dysarthria. (5/337)

OBJECTIVE: "Cerebellar mutis" and subsequent dysarthria (MSD) is a documented complication of posterior fossa surgery in children. In this prospective study the following risk factors for MSD were assessed: type, size and site of the tumour; hydrocephalus at presentation and after surgery, cerebellar incision site, postoperative infection, and cerebellar swelling. METHODS: In a consecutive series of 42 children with a cerebellar tumour, speech and neuroradiological studies (CT and MRI) were systematically analysed preoperatively and postoperatively. Speech was assessed using the Mayo Clinic lists and the severity of dysarthria using the Michigan rating scale. RESULTS: Twelve children (29%) developed MSD postoperatively. The type of tumour, midline localisation, and vermal incision were significant single independent risk factors. In addition, an interdependency of possible risk factors (tumour>5 cm, medulloblastoma) was found. CONCLUSION: MSD often occurs after paediatric cerebellar tumour removal and is most likely after removal of a medulloblastoma with a maximum lesion diameter>5 cm.  (+info)

Evidence for an ependymoma tumour suppressor gene in chromosome region 22pter-22q11.2. (6/337)

Ependymomas are glial tumours of the brain and spinal cord. The most frequent genetic change in sporadic ependymoma is monosomy 22, suggesting the presence of an ependymoma tumour suppressor gene on that chromosome. Clustering of ependymomas has been reported to occur in some families. From an earlier study in a family in which four cousins developed an ependymoma, we concluded that an ependymoma-susceptibility gene, which is not the NF2 gene in 22q12, might be located on chromosome 22. To localize that gene, we performed a segregation analysis with chromosome 22 markers in this family. This analysis revealed that the susceptibility gene may be located proximal to marker D22S941 in 22pter-22q11.2. Comparative genomic hybridization showed that monosomy 22 was the sole detectable genetic aberration in the tumour of one of the patients. Loss of heterozygosity studies in that tumour revealed that, in accordance to Knudson's two-hit theory of tumorigenesis, the lost chromosome 22 originated from the parent presumed to have contributed the wild-type allele of the susceptibility gene. Thus, our segregation and tumour studies collectively indicate that an ependymoma tumour suppressor gene may be present in region 22pter-22q11.2.  (+info)

Expression of bisecting GlcNAc in pediatric brain tumors and its association with tumor cell response to vinblastine. (7/337)

Increased expression of the bisecting GlcNAc has been correlated with tumor progression in several experimental tumor models. Its expression and function in brain tumors are, however, not yet known. In this study, we investigated expression of the bisecting GlcNAc structure in a series of pediatric brain tumors and its relationship to tumor response to vinblastine. A plant lectin (E-PHA) that recognizes the bisecting GlcNAc structure was used for detection of this molecule in a total of 90 pediatric brain tumors and normal brain tissue specimens. Our results showed that, whereas E-PHA staining was undetectable in the normal brain tissue, pediatric brain tumor specimens exhibited different levels of reactivity. Lectin staining was particularly prominent in high-grade astrocytomas (73%) and ependymomas (72%). In astrocytomas, there was a positive correlation with the tumor grade, which suggests that the bisecting GlcNAc may be of particular interest as a tumor marker for diagnosis and/or prognosis. By using a human glioma cell culture model, we have found that treatment of these cells with E-PHA lectin enhances their sensitivity to vinblastine. E-PHA interacted directly with the drug transporter P-glycoprotein and inhibited its drug efflux function. In a drug-resistant glioma cell line transfected with the mdr1 gene, drug resistance was reversed by E-PHA. Our findings indicate that: (a) expression of the bisecting GlcNAc in pediatric brain tumors may have a potential relevance as a tumor marker; and (b) glioma response to chemotherapy may be modulated through the bisecting GlcNAc.  (+info)

Neuropsychological consequences of cerebellar tumour resection in children: cerebellar cognitive affective syndrome in a paediatric population. (8/337)

Acquired cerebellar lesions in adults have been shown to produce impairments in higher function as exemplified by the cerebellar cognitive affective syndrome. It is not yet known whether similar findings occur in children with acquired cerebellar lesions, and whether developmental factors influence their presentation. In studies to date, survivors of childhood cerebellar tumours who demonstrate long-term deficits in cognitive functions have undergone surgery as well as cranial irradiation or methotrexate treatment. Investigation of the effects of the cerebellar lesion independent of the known deleterious effects of these agents is important for understanding the role of the cerebellum in cognitive and affective development and for informing treatment and rehabilitation strategies. If the cerebellar contribution to cognition and affect is significant, then damage in childhood may influence a wide range of psychological processes, both as an immediate consequence and as these processes fail to develop normally later on. In this study we evaluated neuropsychological data in 19 children who underwent resection of cerebellar tumours but who received neither cranial irradiation nor methotrexate chemotherapy. Impairments were noted in executive function, including planning and sequencing, and in visual-spatial function, expressive language, verbal memory and modulation of affect. These deficits were common and in some cases could be dissociated from motor deficits. Lesions of the vermis in particular were associated with dysregulation of affect. Behavioural deficits were more apparent in older than younger children. These results reveal that clinically relevant neuropsychological changes may occur following cerebellar tumour resection in children. Age at the time of surgery and the site of the cerebellar lesion influence the neurobehavioural outcome. The results of the present study indicate that the cerebellar cognitive affective syndrome is evident in children as well as in adults, and they provide further clinical evidence that the cerebellum is an essential node in the distributed neural circuitry subserving higher-order behaviours.  (+info)

Clear Cell Ependymoma of Spinal Cord: A Case ReportClear Cell Ependymoma of Spinal Cord: A Case Report
Clear cell variant of ependymoma is almost exclusively located in the supratentorial region. Only few cases of this tumor that located in the spinal cord have been reported. Here we report one case of intramedullary clear cell ependymoma of the lumbar spinal cord. In microscopic examination, the tumor cells were round to oval with moderate amounts of clear cytoplasm and centrally located large nuclei, resembling oligodendroglioma. Typical features of ependymoma, such as ependymal clefts, perivascular pseudorosettes, as well as nuclear pseudoinclusions and grooves were identified. Albeit being rare, clear cell ependymoma could be mentioned in differential diagnosis of clear cell tumors in this area.
http://ijp.iranpath.org/article_8533.html
Tailored therapy: Surgical and radiosurgical treatment for two distinct myxopapillary ependymomas in the same patient. A case...Tailored therapy: Surgical and radiosurgical treatment for two distinct myxopapillary ependymomas in the same patient. A case...
TY - JOUR. T1 - Tailored therapy. T2 - Surgical and radiosurgical treatment for two distinct myxopapillary ependymomas in the same patient. A case report. AU - Zekaj, Edvin. AU - Iess, Guglielmo. AU - Saleh, Christian. AU - Servello, Domenico. N1 - Funding Information: Source of financial support Publisher Copyright: © 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2020/7. Y1 - 2020/7. N2 - Myxopapillary ependymomas are low grade neoplasms, which originate mostly from the medullary conus, cauda equina and the filum terminale. To date the principal treatment is surgical, total- or subtotal removal (GTR or STR), which can be associated with adjuvant radiotherapy. We report a patient with two tumor locations, one larger tumor at the L3 to S1 level and a smaller S2-S3 localized lesion. The patient was treated successfully with a combined approach of GTR of L3-S1 lesion and radiosurgical treatment of S2-S3 lesion.. AB - Myxopapillary ependymomas are low grade ...
https://moh-it.pure.elsevier.com/en/publications/tailored-therapy-surgical-and-radiosurgical-treatment-for-two-dis
Pediatric ependymoma - WikipediaPediatric ependymoma - Wikipedia
Pediatric ependymomas are similar in nature to the adult form of ependymoma in that they are thought to arise from radial glial cells lining the ventricular system. However, they differ from adult ependymomas in which genes and chromosomes are most often affected, the region of the brain they are most frequently found in, and the prognosis of the patients. Children with certain hereditary diseases, such as neurofibromatosis type II (NF2), have been found to be more frequently afflicted with this class of tumors, but a firm genetic link remains to be established. Symptoms associated with the development of pediatric ependymomas are varied, much like symptoms for a number of other pediatric brain tumors including vomiting, headache, irritability, lethargy, and changes in gait. Although younger children and children with invasive tumor types generally experience less favorable outcomes, total removal of the tumors is the most conspicuous prognostic factor for both survival and relapse. Ependymomas ...
https://en.wikipedia.org/wiki/Pediatric_ependymoma
Ependymal tumor - WikipediaEpendymal tumor - Wikipedia
An ependymal tumor is a type of brain tumor that begins in cells lining the spinal cord central canal (fluid-filled space down the center) or the ventricles (fluid-filled spaces of the brain). Ependymal tumors may also form in the choroid plexus (tissue in the ventricles that makes cerebrospinal fluid). Also called ependymoma. Ependymal tumor entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material from the U.S. National Cancer Institute document Dictionary of Cancer Terms ...
https://en.wikipedia.org/wiki/Ependymal_tumor
Spinal myxopapillary ependymoma | Radiology Reference Article | Radiopaedia.orgSpinal myxopapillary ependymoma | Radiology Reference Article | Radiopaedia.org
Spinal myxopapillary ependymomas are a variant type of spinal ependymoma that occur almost exclusively in the conus medullaris and filum terminale. They represent 13% of all spinal ependymomas, and are by far the most common tumours of the conus ...
https://radiopaedia.org/articles/spinal-myxopapillary-ependymoma
Tanycytic Ependymoma disease: Malacards - Research Articles, Drugs, Genes, Clinical TrialsTanycytic Ependymoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
MalaCards based summary : Tanycytic Ependymoma is related to ependymoma and benign ependymoma. An important gene associated with Tanycytic Ependymoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include spinal cord and brain, and related phenotypes are Increased proliferation and growth/size/body region ...
https://www.malacards.org/card/tanycytic_ependymoma
ASTRO 2015: Pediatric Patients With Ependymoma Have Favorable Outcomes With Immediate Postsurgical Radiation Therapy - The ASCO...ASTRO 2015: Pediatric Patients With Ependymoma Have Favorable Outcomes With Immediate Postsurgical Radiation Therapy - The ASCO...
Outcomes for pediatric patients as young as 12 months old with ependymoma who are treated with immediate postoperative radiation therapy are favorable and consistent, based upon tumor surgical resection and tumor grade, according to research presented by Merchant et al (Abstract 1) on October 18, 2015, at the American Society for Radiation Oncology (ASTRO) 57th Annual Meeting. The Childrens Oncology Group ACNS0121 trial was a prospective study for childhood ependymoma-a rare brain and spinal cord tumor. This was the largest prospective trial for childhood ependymoma ever conducted and the first cooperative group trial for ependymoma to target the postoperative tumor bed and to use three-dimensional conformal radiation therapy and intensity-modulated radiation therapy.. In addition, this study is significant in that it was the first to systematically use immediate postoperative radiation therapy in children under the age of 3 with this type of brain tumor. Many children diagnosed with ependymoma ...
https://ascopost.com/News/33979
Ependymal tumor | Open Access articles | Open Access journals | Conference Proceedings | Editors | Authors | Reviewers |...Ependymal tumor | Open Access articles | Open Access journals | Conference Proceedings | Editors | Authors | Reviewers |...
An ependymal tumor is a type of brain tumor that begins in cells lining the spinal cord central canal (fluid-filled space down the center) or the ventricles (fluid-filled spaces of the brain). Ependymal tumors may also form in the choroid plexus (tissue in the ventricles that makes cerebrospinal fluid). Also called ependymoma. ...
http://research.omicsgroup.org/index.php/Ependymal_tumor
Spinal Cord Ependymoma disease: Malacards - Research Articles, Drugs, Genes, Clinical TrialsSpinal Cord Ependymoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
MalaCards based summary : Spinal Cord Ependymoma, also known as ependymal neoplasm of the spinal cord, is related to benign ependymoma and cellular ependymoma. An important gene associated with Spinal Cord Ependymoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways is Hippo signaling pathway - multiple species. The drugs Lapatinib and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2) ...
https://www.malacards.org/card/spinal_cord_ependymoma
Ependymoma - Dana-Farber Cancer Institute | Boston, MAEpendymoma - Dana-Farber Cancer Institute | Boston, MA
Ependymoma (ependymal tumor) may arise in the ventricles of the brain or in the spinal cord. Learn about ependymoma and find information on how we support and care for children and teens with ependymoma before, during, and after treatment.
https://www.dana-farber.org/ependymoma/
Final Diagnosis -- Case 95Final Diagnosis -- Case 95
DISCUSSION. Ependymomas are the third most common brain tumor in the pediatric population. Over 90% of these cases are intracranial, while in adults, most ependymomas occur in the spinal cord. In children, most intracranial ependymomas are infratentorial, where their relationship to the floor of the fourth ventricle often makes complete resection difficult. Supratentorial ependymomas may occur in relation to the lateral ventricles or in the midline, as in this case. It has been noted that supratentorial midline ependymomas are more likely to exhibit clear-cell morphology (20) , which may so dominate the histologic picture as to warrant a diagnosis of clear-cell variant of ependymoma. In the case presented here, only focal areas showed clear-cell histology, while most areas showed the more classic architecture of a cellular ependymoma. This case also had numerous areas of necrosis, significant endothelial proliferation and an extrememly high mitotic rate: sometimes as many as 5 mitotic figures ...
http://path.upmc.edu/cases/case95/dx.html
Pediatric Ependymoma Treatment & Management: Medical Care, Surgical Care, ConsultationsPediatric Ependymoma Treatment & Management: Medical Care, Surgical Care, Consultations
Ependymoma is the third most common brain tumor in children, accounting for approximately 10% of primary CNS neoplasms. It is a neuroepithelial tumor that arises within, or adjacent to, the ependymal lining of the ventricular system or the central canal of the spinal cord.
https://emedicine.medscape.com/article/986333-treatment
Spinal Myxopapillary Ependymoma Epidemiology - NeurosurgerySpinal Myxopapillary Ependymoma Epidemiology - Neurosurgery
Abdallah et al. retrospectively reviewed the medical records of 38 primary spinal myxopapillary ependymoma cases who underwent surgery at 2 neurosurgical centers spanning 16 years, from 2004 to 2019. All pediatric cases (patient age ,18 years) who were diagnosed with MPE and re-presented with spinal seeding/drop metastases (SSM) were selected as the core sample for this study. Relevant literature was briefly reviewed.. Three pediatric MPE cases (2 females and 1 male) experienced SSM. The mean age at first presentation was 12.0 ± 1.0 years. The mean preoperative course was 2.9 ± 1.2 months. The predominant location was the lumbar spine in 2 tumors (both originated from filum terminale [FT]). Two tumors were located intradural intramedullary. Gross-total resection was achieved in 2 patients. No patient had neurofibromatosis type 2. No adjuvant treatment was given after the first surgery. The mean period between the first diagnosis and diagnosis of SSM was 44.0 ± 31.5 months. The location of SSM ...
https://neurosurgery.directory/2020/08/10/spinal-myxopapillary-ependymoma-epidemiology/
Giant cell ependymoma of the thoracic spinal cord | springermedizin.deGiant cell ependymoma of the thoracic spinal cord | springermedizin.de
We report a new case of giant cell ependymoma (GCE) of the thoracic spinal cord. Ependymomas predominate in children and young adults and are
https://www.springermedizin.de/giant-cell-ependymoma-of-the-thoracic-spinal-cord/11075834
Myxopapillary ependymoma | Genetic and Rare Diseases Information Center (GARD) - an NCATS ProgramMyxopapillary ependymoma | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Myxopapillary ependymoma
https://rarediseases.info.nih.gov/diseases/10633/myxopapillary-ependymoma
Treatment of Children With Recurrent Refractory Brain/Solid Tumors and Recurrent Ependymoma - Full Text View - ClinicalTrials...Treatment of Children With Recurrent Refractory Brain/Solid Tumors and Recurrent Ependymoma - Full Text View - ClinicalTrials...
Aberrant DNA methylation is frequently observed in many pediatric solid tumors, but in particularly several entities such as ependymoma, medulloblastoma, embryonal tumor with multilayered rosettes, atypical/teratoid rhabdoid tumor, neuroblastoma and wilms tumor have promoter hypermethylation. Treatment with DNMTi (DNA methyltransferase inhibitors) agents such as 5-azacytidine has been shown to be safe and efficacious in adult myelodysplastic syndromes, causing significant decreased DNA methylation in blood, with maximum effect at day 15 of each cycle. However, monotherapy with DNMTi has been shown to result in resistance in leukamias and efficacy in solid tumours is limited. Synergy between DNMTi and platinum agents has shown promise in pre-clinical models including pediatric ependymoma, and in addition, the combination of demethylating agents with carboplatin has provided promising results in platinum resistant ovarian cancers. However, this approach has not been applied to pediatric solid ...
https://clinicaltrials.gov/ct2/show/NCT03206021?term=cns+tumor&
Metastatic ependymoma of the sacrum<...Metastatic ependymoma of the sacrum<...
TY - JOUR. T1 - Metastatic ependymoma of the sacrum. AU - Miralbell, Raymond. AU - Louis, David N.. AU - OKeeffe, David. AU - Rosenberg, Andrew E.. AU - Suit, Herman D.. PY - 1990/5/15. Y1 - 1990/5/15. N2 - Ependymomas originating in the sacrum or extraspinal parasacral soft tissues are rare tumors. The majority are of the myxopapillary type and may be locally destructive. Even though metastases are not uncommon in retrosacral ependymomas, they have been rarely described in intrasacral locations. A case is reported of a large intrasacral ependymoma with metastases to several vertebrae. Radiologic and pathologic studies are presented. Treatment options are discussed.. AB - Ependymomas originating in the sacrum or extraspinal parasacral soft tissues are rare tumors. The majority are of the myxopapillary type and may be locally destructive. Even though metastases are not uncommon in retrosacral ependymomas, they have been rarely described in intrasacral locations. A case is reported of a large ...
https://miami.pure.elsevier.com/en/publications/metastatic-ependymoma-of-the-sacrum
Late dissemination of ependymoma: case reportLate dissemination of ependymoma: case report
BADEMCI, G. et al. Late dissemination of ependymoma: case report. Neurocirugía [online]. 2007, vol.18, n.4, pp.333-336. ISSN 1130-1473.. Spinal cord dissemination over 10 years after surgical removal of the fourth ventricle ependymoma without local recurrence is extremely rare. A 49-year-old male underwent a macroscopically gross total emoval of the fourth ventricle ependymoma and postoperative radiothe rapy to the posterior fossa. Twelve years after the initial operation, the patient complained from uncontrolled fever attacks, low back pain and numbness of the legs. Spinal Magnetic Resonance Imaging revealed intradural extramedullary mass lesions located at the thoracic 2-3 and lumbar 5 vertebrae levels. Cerebrospinal fluid exami nation showed no tumour cells. He underwent total excision of these spinal lesions. Although the majority of the recurrences take place within a few years after surgery, we experienced a case with multiple spinal disseminations 12 years after the resection of the ...
http://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S1130-14732007000400008&lng=en&nrm=iso&tlng=en
spinal cord ependymoma [Operative Neurosurgery]spinal cord ependymoma [Operative Neurosurgery]
Spinal cord ependymoma Epidemiology Intramedullary ependymoma is a rare neoplasms, comprising approximately 5% of all CNS tumors and 15% of all spinal cord tumors. Ependymomas are the most frequent spinal cord tumors in adult patients. Some authors believe it is more common in the fourth and fifth decade while others propose a wider distribution spanning between the second and sixth decade of life
https://operativeneurosurgery.com/doku.php?id=spinal_cord_ependymoma&rev=1570538089
A retrospective analysis of recurrent intracranial ependymoma - Antony - 2014 - Pediatric Blood & Cancer - Wiley Online LibraryA retrospective analysis of recurrent intracranial ependymoma - Antony - 2014 - Pediatric Blood & Cancer - Wiley Online Library
Median duration of follow-up was 52 months (7-171 months). Median age at initial diagnosis was 4 years (0.3-19 years) with 8 patients younger than 3 years at presentation. Eleven patients had anaplastic and 11 cellular pathologies. Eighteen patients had infratentorial tumors at diagnosis and 3 (all infratentorial) had metastatic spinal cord involvement at presentation. Cerebrospinal fluid involvement was not identified at diagnosis or relapse. Median time to first recurrence was 16 months (1.3 to 115 months). The number of recurrences in each patient ranged from 1 to 9 (median = 2). Thirty-seven recurrences (63%) were detected asymptomatically by surveillance imaging. Fifteen recurrences (26%) arose outside the initial tumor site. Recurrences were treated by surgical resection (45), with irradiation (30), and with various oral chemotherapies (23) with (7) or without (16) conventional chemotherapy. The 5 and 10 year overall survival rates from first recurrence were 0.37 ± 0.14 and 0.25 ± 0.14. ...
http://onlinelibrary.wiley.com/doi/10.1002/pbc.24996/abstract
Carboplatin and Bevacizumab for Recurrent Ependymoma - Full Text View - ClinicalTrials.govCarboplatin and Bevacizumab for Recurrent Ependymoma - Full Text View - ClinicalTrials.gov
Histologically proven intra-cranial or spinal ependymoma or anaplastic ependymoma. There must be pathologic or imaging confirmation of tumor progression or regrowth.. The patient must have at least 1 block of tissue or 15 unstained slides at a minimum available for central pathology review and molecular profiling of the tissue sample.. All patients must sign an informed consent indicating that they are aware of the investigational nature of this study. Patients must have signed an authorization for the release of their protected health information.. Patients must be , 18 years old.. Patients must have a Karnofsky performance status of , 60.. Patients must have adequate bone marrow function (WBC , 3,000/microliter, ANC , 1,500/mm^3, platelet count of , 100,000/mm^3, and hemoglobin , 10 gm/dl), adequate liver function (SGOT [AST ,92.5 Units/L] and bilirubin , 1.5 mg/dL), and adequate renal function (creatinine , 1.5 mg/dL and calculated creatinine clearance , 60 cc/min) before starting therapy. ...
https://clinicaltrials.gov/ct2/show/NCT01295944?term=Brain+and+Spinal+Tumors&rank=8
Pediatric Cancers | Cancer NetworkPediatric Cancers | Cancer Network
Dr. Merchant provides a comprehensive overview of intracranial ependymoma in children. As he points out, most of the current information regarding childhood intracranial ependymoma has come from single-institution retrospective reviews. Of the prognostic indicators mentioned in the article, both young age and subtotal resection are widely accepted. Children less than 3 years old have a worse prognosis than older children, possibly because of more aggressive tumor biology, reluctance to give postoperative radiotherapy, or use of lower doses of radiotherapy. Regarding the degree of surgical resection, assessment by postoperative imaging is more important than the neurosurgeons perspective on whether a gross total or subtotal resection has been performed.[1,2] ...
https://www.cancernetwork.com/pediatric-cancers/page/10/0
2018 Session | Pediatric Ependymoma: The Science Driving Patient Care · ASPHO2018 Session | Pediatric Ependymoma: The Science Driving Patient Care · ASPHO
Thank you for purchasing the online recording for the 2018 Conference. To access the recording, please sign-in using the login button at the top of the page.. If you would like to order the recording, please call 847-375-4716 or visit the ASPHO store.. *To view the online recordings you must have a high-speed Internet connection, and speakers or headphones attached to your device. If you have difficulty playing the recordings, enable JavaScript, and consider upgrading to a web browser that supports HTML5 video. ...
http://aspho.org/2018-session-pediatric-ependymoma-the-science-driving-patient-care
How are ependymomas and anaplastic ependymomas treated?How are ependymomas and anaplastic ependymomas treated?
ependymomas and anaplastic ependymomas usually do not pass into normal brain tissue as do other gliomas. so surgery may work well if all of the tumor is removed.
https://www.webmd.com/cancer/brain-cancer/qa/how-are-ependymomas-and-anaplastic-ependymomas-treated
Ependymoma Basics | CERN FoundationEpendymoma Basics | CERN Foundation
Ependymoma is a rare type of primary brain or spinal cord tumor found in adults and children. We answers questions like, What is ependymoma?
https://www.cern-foundation.org/education/ependymoma-basics
Ependymoma | Radiology Case | Radiopaedia.orgEpendymoma | Radiology Case | Radiopaedia.org
This case demonstrates the imaging features of an ependymoma. The patient underwent posterior fossa craniotomy and resection of the tumour. Histopathology confirmed the diagnosis of conventional ependymoma (WHO grade II).
https://radiopaedia.org/cases/ependymoma-15
January 10, 2014 - 2nd Anniversary of the Worst day of our lives | Childhood EpendymomaJanuary 10, 2014 - 2nd Anniversary of the Worst day of our lives | Childhood Ependymoma
Diagnosis Day Wow, it is hard to believe 2 years have passed since Nicolas was diagnosed with Ependymoma. It feels like only yesterday we were all gathered at Sick Kids rallying around to support him and his parents and trying to come to terms with this diagnosis. I am so happy to say that Nicolas…
https://ependymoma.wordpress.com/2014/01/10/january-10-2014-2nd-anniversary-of-the-worst-day-of-our-lives/
Update: Spinal cord Ependymoma | NeurocirugiaUpdate: Spinal cord Ependymoma | Neurocirugia
Spinal cord ependymomas are rare neoplasms, comprising approximately 5% of all CNS tumors and 15% of all spinal cord tumors. Ependymomas are the most frequent
http://neurocirugia.com/2016/12/27/update-spinal-cord-ependymoma/
Genome-Wide Transcriptional Profiling of Ependymoma: Insight to Prognostic Indicators | AbstractGenome-Wide Transcriptional Profiling of Ependymoma: Insight to Prognostic Indicators | Abstract
Pediatric ependymomas are characterized by unpredictable biological behavior and prognosis. The purpose of this study is to identify genes that are se..
http://raredisorders.imedpub.com/abstract/genomewide-transcriptional-profiling-of-ependymoma-insight-to-prognostic-indicators-9180.html
YAP1/TAZ drives ependymoma-like tumour formation in mice by Noreen Eder, Federico Roncaroli et al.YAP1/TAZ drives ependymoma-like tumour formation in mice by Noreen Eder, Federico Roncaroli et al.
YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to drive brain tumour formation in mice. Neuronal differentiation is inhibited in the hippocampus. Deletion of YAP1s negative regulators LATS1 and LATS2 kinases in NEX-Cre lineage in double conditional knockout mice also generates similar tumours, which are rescued by deletion of YAP1 and its paralog TAZ. YAP1/TAZ-induced mouse tumours display molecular and ultrastructural characteristics of human ependymoma. RNA sequencing and quantitative proteomics of mouse tumours demonstrate similarities to YAP1-fusion induced supratentorial ependymoma. Finally, we find that transcriptional cofactor HOPX is upregulated in mouse models and in human YAP1-fusion induced ependymoma, supporting their similarity. Our results show that uncontrolled YAP1/TAZ activity in
https://escholarship.umassmed.edu/oapubs/4256/
Pray for Campbell: Labor Day UpdatePray for Campbell: Labor Day Update
Campbell has been battling Anaplastic Ependymoma, a rare form of Brain/Spine Cancer, since August 2009. She has undergone five brain surgeries, bacterial meningitis (as a result of one of her treatments for brain cancer) for 8 months, five brain tumors, five spinal tumors, one spinal surgery, a total of 116 rounds of radiation therapy, countless days, weeks and even months away from home while in treatment. She has failed one chemotherapy protocol and two clinical trials targeted at Recurrent Ependymoma. On January 27, 2013, Cams care was transferred to St. Jude for enrollment in a new clinical trial, also for Anaplastic Ependymoma, available only at St. Jude. This is for an old drug, called 5FU, which has shown promise in labs at St. Jude ...
http://pray4cam.blogspot.com/2009/09/labor-day-update.html
Pray for Campbell: Update - 6/4Pray for Campbell: Update - 6/4
Campbell has been battling Anaplastic Ependymoma, a rare form of Brain/Spine Cancer, since August 2009. She has undergone five brain surgeries, bacterial meningitis (as a result of one of her treatments for brain cancer) for 8 months, five brain tumors, five spinal tumors, one spinal surgery, a total of 116 rounds of radiation therapy, countless days, weeks and even months away from home while in treatment. She has failed one chemotherapy protocol and two clinical trials targeted at Recurrent Ependymoma. On January 27, 2013, Cams care was transferred to St. Jude for enrollment in a new clinical trial, also for Anaplastic Ependymoma, available only at St. Jude. This is for an old drug, called 5FU, which has shown promise in labs at St. Jude ...
http://pray4cam.blogspot.com/2011/06/update-64.html
Adult Ependymal Tumors: Prognosis and The MDACC Experience | CERN FoundationAdult Ependymal Tumors: Prognosis and The MDACC Experience | CERN Foundation
Ependymomas in adults are rare and often misdiagnosed. This study reports on a series of adult patients with confirmed ependymoma treated at M.D. Anderson Cancer Center (MDACC).
https://www.cern-foundation.org/news/adult-ependymal-tumors-prognosis-and-the-mdacc-experience
myxopapillary Ependymoma | Cancer Survivors Networkmyxopapillary Ependymoma | Cancer Survivors Network
Hi Diane, My 11 yr old son also had this cancer (they called it cancer from Day 1). We are in PA. We went to Childrens Hospital Of Philadelphia and received excellent care. He had two tumers in his spine. The surgeries were successful....all of it was removed. We were encouraged to get radiation to the brain and spine, and we were all set to get Proton Radiation, when a Dr. from Boston Mass. General called me (we had sent them our sons MRIs and medical records for another opinion). He told us, that since the operation was successful (removed the tumor completely) and since these are slow growing tumors, we had a unique window of opportunity....we could consider not doing the radiation since he was about to hit puberty. On one hand Drs were saying Do the radiation.. and on the other Dr.s were saying It is not worth the risk at this time. We decided to not do the radiation and just watch for any new tumors with MRIs every 3 months, then every 4 months. Also, we were told that once ...
https://csn.cancer.org/comment/1330815
myxopapillary Ependymoma | Cancer Survivors Networkmyxopapillary Ependymoma | Cancer Survivors Network
Hi Diane, My 11 yr old son also had this cancer (they called it cancer from Day 1). We are in PA. We went to Childrens Hospital Of Philadelphia and received excellent care. He had two tumers in his spine. The surgeries were successful....all of it was removed. We were encouraged to get radiation to the brain and spine, and we were all set to get Proton Radiation, when a Dr. from Boston Mass. General called me (we had sent them our sons MRIs and medical records for another opinion). He told us, that since the operation was successful (removed the tumor completely) and since these are slow growing tumors, we had a unique window of opportunity....we could consider not doing the radiation since he was about to hit puberty. On one hand Drs were saying Do the radiation.. and on the other Dr.s were saying It is not worth the risk at this time. We decided to not do the radiation and just watch for any new tumors with MRIs every 3 months, then every 4 months. Also, we were told that once ...
https://csn.cancer.org/node/186876
Gene sequencing discovers common driver of childhood brain tumor ependymoma - ONAGene sequencing discovers common driver of childhood brain tumor ependymoma - ONA
The most common genetic alteration ever reported in the brain tumor ependymoma has been identified. Researchers also have evidence that the alteration drives tumor development.
http://www.oncologynurseadvisor.com/web-exclusives/gene-sequencing-discovers-common-driver-of-childhood-brain-tumor-ependymoma/article/338540/
Quantitative imaging analysis of posterior fossa ependymoma location in children | springermedizin.deQuantitative imaging analysis of posterior fossa ependymoma location in children | springermedizin.de
Ependymoma is one of the most common central nervous system neoplasms in children and comprises approximately 5.5 % of pediatric brain tumors [ 1 ].
https://www.springermedizin.de/quantitative-imaging-analysis-of-posterior-fossa-ependymoma-loca/10057120
Johns Hopkins Medicine: Find a DoctorJohns Hopkins Medicine: Find a Doctor
Expertise, Disease and Conditions: Aneurysmal Bone Cyst, Back Injuries, Basilar Impression, Basilar Invagination, Cauda Equina Syndrome, Cavernous Angioma, Cervical Disc Herniation, Cervical Myelopathy, Cervical Radiculopathy, Cervical Spondylosis, Chiari Malformations, Chondrosarcoma, Chordomas, Cranio-cervical Junction Pathology, Degenerative Disc Disease, Degenerative Spine Disease, Giant Cell Tumor, Hemangioblastoma, Hemangiomas, Kyphosis, Lumbar Degenerative Disease, Lumbar Disc Herniation, Lumbar Radiculopathy, Myxopapillary Ependymoma, Neck Cancer, Neck Masses, Nerve Sheath Tumor, Neurosurgery, Osteoblastoma, Osteoid Osteoma, Radiculopathy, Sacral Tumors, Sarcoma, Schwannoma, Sciatica, Scoliosis, Spinal Column Tumors, Spinal Cord Injury, Spinal Cord Malformation, Spinal Cord Tumors, Spinal Decompression, Spinal Deformities, Spinal Dural Fistula, Spinal Ependymoma, Spinal Fixation, Spinal Fusion, Spinal Infection, Spinal Instability, Spinal Meningioma, Spinal Metastases, Spinal ...
https://www.hopkinsmedicine.org/profiles/results/directory/?currpage=1&spec_disease=Neck%20Cancer&dbase=main&CLEARPAGECACHE=false&setsize=10&pageCount=10&directRef=%2Fdoctors%2Fresults%2Fdirectory%2F
Johns Hopkins Medicine: Find a DoctorJohns Hopkins Medicine: Find a Doctor
Expertise, Disease and Conditions: Aneurysmal Bone Cyst, Back Injuries, Basilar Impression, Basilar Invagination, Cauda Equina Syndrome, Cavernous Angioma, Cervical Degenerative Disc Disease, Cervical Degenerative Disc Herniation, Cervical Myelopathy, Cervical Radiculopathy, Cervical Spine Trauma, Cervical Spondylosis, Chiari Malformations, Chondrosarcoma, Chordomas, Cranio-cervical Junction Pathology, Degenerative Disc Disease, Degenerative Spine Disease, Disc Pain, Hemangioblastoma, Hemangiomas, Kyphosis, Lumbar Degenerative Disease, Lumbar Disc Herniation, Lumbar Radiculopathy, Minimally Invasive Spine Surgery, Minimally Invasive Surgery, Myxopapillary Ependymoma, Nerve Sheath Tumor, Neurosurgery, Osteoblastoma, Radiculopathy, Sacral Tumors, Sarcoma, Schwannoma, Sciatica, Scoliosis, Spinal Column Tumors, Spinal Cord Injury, Spinal Cord Malformation, Spinal Cord Tumors, Spinal Decompression, Spinal Deformities, Spinal Dural Fistula, Spinal Ependymoma, Spinal Fixation, Spinal Fusion, Spinal ...
https://www.hopkinsmedicine.org/profiles/results/directory/?CLEARPAGECACHE=false&pagecount=20&spec_disease=Minimally%20Invasive%20Surgery&currpage=1&directRef=%2Fdoctors%2Fresults%2Fdirectory%2F
Surgical management of a rare myxopapillary ependymoma of the gluteal region: A case report - Surgical Neurology InternationalSurgical management of a rare myxopapillary ependymoma of the gluteal region: A case report - Surgical Neurology International
1. Akpolat N, Bozlak N, Kazez A, Köseoğullari AA. Sacrococcygeal extraspinal ependymoma: A case report. Turk J Pediatr. 2003. 45: 276-9. 2. Aktuğ T, Hakgüder G, Sarioğlu S, Akgür FM, Olguner M, Pabuçcuoğlu U. Sacrococcygeal extraspinal ependymomas: The role of coccygectomy. J Pediatr Surg. 2000. 35: 515-8. 3. Alexiou GA, Sfakianos G, Moschovi M, Athanasiadou S, Stefanaki K, Prodromou N. Myxopapillary ependymoma of the sacrococcygeal region presenting as a pilonidal sinus. Pediatr Neurosurg. 2012. 48: 64-65. 4. Amin R, Berdan E, Knipstein J, Jarzembowski J, Siddiqui S. Extraspinal sacrococcygeal ependymoma masquerading as sacrococcygeal teratoma in the pediatric patient. Pediatr Surg Int. 2018. 34: 109-12. 5. Anderson MS. Myxopapillary ependymomas presenting in the soft tissue over the sacrococcygeal region. Cancer. 1966. 19: 585-90. 6. Batich KA, Riedel RF, Kirkpatrick JP, Tong BC, Eward WC, Tan CL. Recurrent extradural myxopapillary ependymoma with oligometastatic spread. Front Oncol. ...
https://surgicalneurologyint.com/surgicalint-articles/surgical-management-of-a-rare-myxopapillary-ependymoma-of-the-gluteal-region-a-case-report/
Neuroradiology On the Net: dicembre 2005Neuroradiology On the Net: dicembre 2005
In the spinal cord, ependymomas most commonly occur at the level of the cervical spine (44%), sometimes extending to the upper thoracic spine (additional 23%). Less commonly, these tumors involved the thoracic cord alone or the conus medullaris. Most ependymomas are hypointense to isointense to spinal cord on T1-weighted images. There may be focal T1 hyperintense areas corresponding to areas of hemorrhage. On T2-weighted sequences, these spinal cord tumors demonstrate high signal in cystic areas with up to one-third containing the cap sign of hypointense signal representing a hemosiderin at the rostral and caudal margins. In addition, ependymomas are commonly seen to enhance with contrast. Usually, there is associated cord edema present. A subtype, myxopapillary ependymoma, is seen in the filum terminale and subcutaneous sacrococcygeal region which appears multilobulated and encapsulated ...
http://neuroradiologyonthenet.blogspot.com/2005_12_01_archive.html
Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival - Fingerprint ...Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival - Fingerprint ...
Amanda E. Marinoff, Clement Ma, Dongjing Guo, Matija Snuderl, Karen D. Wright, Peter E. Manley, Hasan Al-Sayegh, Claire E. Sinai, Nicole J. Ullrich, Karen Marcus, Daphne Haas-Kogan, Liliana Goumnerova, Wendy B. London, Mark W. Kieran, Susan N. Chi, Jason Fangusaro, Pratiti Bandopadhayay* ...
https://www.scholars.northwestern.edu/en/publications/rethinking-childhood-ependymoma-a-retrospective-multi-center-anal/fingerprints/
malignant glioma spinal cord drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search enginemalignant glioma spinal cord drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-minor] Carboplatin / administration & dosage. Child, Preschool. Cisplatin / administration & dosage. Cognition Disorders / etiology. Cranial Irradiation / adverse effects. Cyclophosphamide / administration & dosage. Developmental Disabilities / etiology. Disease-Free Survival. Ependymoma / drug therapy. Ependymoma / mortality. Ependymoma / surgery. Etoposide / administration & dosage. Follow-Up Studies. Ganglioglioma / drug therapy. Ganglioglioma / metabolism. Ganglioglioma / radiotherapy. Ganglioglioma / surgery. Glioma / drug therapy. Glioma / mortality. Glioma / radiotherapy. Glioma / surgery. Humans. Infant. Medulloblastoma / drug therapy. Medulloblastoma / mortality. Medulloblastoma / radiotherapy. Medulloblastoma / surgery. Mitotic Index. Neuroectodermal Tumors, Primitive / drug therapy. Neuroectodermal Tumors, Primitive / mortality. Neuroectodermal Tumors, Primitive / radiotherapy. Neuroectodermal Tumors, Primitive / surgery. Quadriplegia / etiology. Retrospective Studies. Sensation ...
http://www.bmlsearch.com/?kwr=malignant+glioma+spinal+cord+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
GENERIC Subependymal GliomaGENERIC Subependymal Glioma
MSH: Rare, slow-growing, benign intraventricular tumors, often asymptomatic and discovered incidentally. The tumors are classified histologically as ependymomas and demonstrate a proliferation of subependymal fibrillary astrocytes among the ependymal tumor cells. (From Clin Neurol Neurosurg 1997 Feb;99(1):17-22),NCI: A benign neoplasm of the brain localized in the vicinity of a ventricular wall and is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic changes.,NCI: A benign, slow growing neoplasm which is typically attached to a ventricular wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic change. Some lesions have the histological features of both subependymoma and ependymoma. It is often detected incidentally and has a very favorable prognosis. (Adapted from WHO.) ...
http://linkedlifedata.com/resource/umls/id/C0206725?generic=true
Neurosurgical Consultants: Degenerative Spinal Conditions: EpendymomasNeurosurgical Consultants: Degenerative Spinal Conditions: Ependymomas
TREATMENT. Surgery. The role of surgery for Filum Terminale Ependymomas depends on the size of the tumor and its relationship to the surrounding roots of the Cauda Equina. We strongly favor Minimally Invasive Microsurgical with Gross Total Resection when possible. Complete surgical resection can be accomplished with small and moderate-sized tumors that remain well circumscribed within the fibrous coverings of the Filum Terminale and are separable from the Nerve Roots of the Cauda Equina. Large tumors can present significant problems for surgical resection. These tumors have been present for many years and present a risk for spread through the Cerebrospinal Fluid (CSF). Filum Terminale Ependymomas that are large and adherent to many Nerve Roots can make total removal difficult to impossible without considerable damage to the Nerve Roots to which they are densely adherent.. ...
http://neurosurgerydallas.com/2_2_4_4.php
Minimally Invasive Brain Tumor Removal, High-Tech Equipment, and Special Facility Benefit Patients - River Cities Capital Fund...Minimally Invasive Brain Tumor Removal, High-Tech Equipment, and Special Facility Benefit Patients - River Cities Capital Fund...
ATLANTA - Forty-seven-year-old Dale Hoggatt is no stranger to hospital operating rooms or surgical procedures. When Hoggatt was in his 30s he was diagnosed with myxopapillary ependymoma, a condition in which slow-growing tumors form and grow on the spine. It has sent him to the operating room seven times for surgical removal, with long recoveries following each procedure. His condition has since left him wheelchair-bound.. When a brain tumor, which likely spread from his spine, was detected on a MRI scan and started to cause problems, Hoggatt mentally prepared himself for another grueling surgery - this time brain surgery - and another lengthy recuperation period. He soon discovered this surgical procedure would be different.. In July, Hoggatt and his wife drove from Vero Beach, Florida to Atlanta to be seen by Costas Hadjipanayis, MD, PhD, assistant professor of neurosurgery, Emory University School of Medicine, and chief of neurosurgery at Emory University Hospital Midtown. Hadjipanayis told ...
http://rccf.com/minimally-invasive-brain-tumor-removal-high-tech-equipment-and-special-facility-benefit-patients/
Ependymoma research projects funded by The Brain Tumour CharityEpendymoma research projects funded by The Brain Tumour Charity
The project is named The PROMOTE Study - Patient Reported Outcome Measures Online To Enhance Communication and Quality of Life after childhood brain tumour.. The PROMOTE team are developing an online programme called KLIK which will be used by children and their families to keep track of any issues they have between consultations.. This research will propel our ability to understand, and potentially prevent, the harsh side effects of brain tumour treatment in children to help accelerate a change for those affected.. Find out more. ...
https://brain-tumour-charity.dev.wearefarm.net/brain-tumour-diagnosis-treatment/types-brain-tumour-children/ependymoma/ependymoma-research/
Keywords nervous + ependymoma + cerebellum | PEIR Digital LibraryKeywords nervous + ependymoma + cerebellum | PEIR Digital Library
Welcome to the Pathology Education Informational Resource (PEIR) Digital Library, a multidisciplinary public access image database for use in medical education. ...
https://peir.path.uab.edu/library/index.php?/tags/13-nervous/681-ependymoma/687-cerebellum
Ependymoma | University HospitalsEpendymoma | University Hospitals
Stay connected with University Hospitals with the UH Now app. This mobile application, available on both Android and iPhone, lets you find a doctor, find a location, log in to your UH Personal Health Record, and schedule an appointment. UH Now also lets you explore health topics that are important to you and your family. Take charge of your health by downloading UH Now today, and get health information delivered right to your fingertips - at the time and place you need it most.. Learn More. ...
https://www.uhhospitals.org/rainbow/services/pediatric-neurology/conditions-and-treatments/pediatric-brain-tumor/conditions-and-treatments/ependymoma
Ependymoma | University HospitalsEpendymoma | University Hospitals
Stay connected with University Hospitals with the UH Now app. This mobile application, available on both Android and iPhone, lets you find a doctor, find a location, log in to your UH Personal Health Record, and schedule an appointment. UH Now also lets you explore health topics that are important to you and your family. Take charge of your health by downloading UH Now today, and get health information delivered right to your fingertips - at the time and place you need it most.. Learn More. ...
https://www.uhhospitals.org/rainbow/services/pediatric-cancer-and-blood-disorders/conditions-and-treatments/ependymoma
Yoke: John 3:16 (Week 13 of Only One Thing and Ependymoma Awareness Day)Yoke: John 3:16 (Week 13 of Only One Thing and Ependymoma Awareness Day)
And thats it friends. God loves us so much he sacrificed his son. It is the strongest, purest love. It is love I will never be capable of; but it is the love I want to dwell in everyday. It is the love that is gifted to me without condition or expectation. I want to remember that God sacrificed his son--his heart and soul and love, for me and mine and yours and every single living soul that has come before and after. ...
http://www.triciaadkins.com/2014/04/john-316-week-13-of-only-one-thing-and.html
In Reply: Selective Intensive Care Unit Admission After Adult Supratentorial Tumor Craniotomy: Complications, Length of Stay,...In Reply: Selective Intensive Care Unit Admission After Adult Supratentorial Tumor Craniotomy: Complications, Length of Stay,...
In Reply: Selective Intensive Care Unit Admission After Adult Supratentorial Tumor Craniotomy: Complications, Length of Stay, and ...
https://repository.ubn.ru.nl/dspace31xmlui/handle/2066/220666
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Functional and Social Independence in Survivors of Pediatric CNS Tumors - The ASCO PostFunctional and Social Independence in Survivors of Pediatric CNS Tumors - The ASCO Post
In a report from the St. Jude Lifetime Cohort Study published in the Journal of Clinical Oncology, Brinkman et al found that 60% of adult survivors of pediatric central nervous system (CNS) tumors do not achieve full functional or social independence in adult life.. In the study, functional and social independence was assessed in 306 survivors, including 130 with astrocytoma, 77 with medulloblastoma, 36 with ependymoma, and 63 with other pediatric CNS tumors. Survivors had a median age of 25.3 years (range = 18.9-53.1 years), with a median time since diagnosis of 16.8 years (range = 10.6-41.8 years).. Functional/social independence was assessed in the categories of employment, living independently, assistance with personal care, assistance with routine needs, obtaining a drivers license, and marital status. Physical performance impairment was defined as scores , 10th percentile in aerobic capacity, strength, flexibility, balance, mobility, and adaptive function.. Factors in ...
https://ascopost.com/News/59173
Brain Tumors | Diagnostic ImagingBrain Tumors | Diagnostic Imaging
Updates for oncologists and hematologists treating primary (astrocytoma, meningioma, medulloblastoma, ependymoma, brain stem glioma) and metastatic brain tumors.
http://www.diagnosticimaging.com/brain-tumors
Pediatric Neuro OncologyPediatric Neuro Oncology
Neuro-oncology deals with the study of spinal cord and brain neoplasms, many of which are very dangerous and life-threatening. It is a Subdivision of medicine that deals with all tumors of the brain and spinal cord, such as glioma, astrocytoma, glioblastoma and ependymoma. The Neuro-Oncology department provides advanced treatment for patients with cancers of the brain and nervous system. Pediatric Neuro-oncology is presently a vibrant field of research. as brain tumors have become the leading cause of cancer-related mortality in children. ...
https://oncology.pediatricsconferences.com/events-list/pediatric-neuro-oncology
Ripley Publishing CompanyRipley Publishing Company
Editors Note: This weekend is the Ripley County Relay for Life in Batesville. Cancer survivors and victims are remembered in special tributes throughout the 24 hour event. The following is a story of a young survivor currently battling the disease.. Kasey McAdams is your normal two year old girl: she loves to play dress up, ride in her Barbie car, listen to her parents read to her, and imitate animal sounds. Whats not normal though is the big scar on the back of her head, the PICC intravenous line in her arm, the fact that she cant play outside when its warm. Thats all due to a brain tumor, discovered six weeks ago when little Kasey started vomiting.. Her parents, Ann Marie and Roger McAdams of Versailles, thought it was a stomach virus, but it continued for 10 days. Doctors thought it could be an gastrointestinal problem. The couple would have preferred that diagnosis, but the Cincinnati Childrens Hospital physicians diagnosed Ependymoma, a cancer that one in 11 people with a brain tumor ...
http://www.ripleynews.com/2013/13-06-18-ojhome.html
The Biology of Thalamic Gliomas | Thalamic Glioma RegistryThe Biology of Thalamic Gliomas | Thalamic Glioma Registry
The biological basis for cancer is revolutionizing our understanding of what drives a normal cell to behave as a tumor cell. The regulation of that process has been broadly defined for some tumors of childhood (such as medulloblastoma and ependymoma). As a result these tumors are routinely being defined based on advanced molecular analysis and those results are now being
https://thalamicgliomaregistry.org/thalamic-gliomas/biology-thalamic-gliomas
Johns Tumor: Buy a Butterfly, Help a KidJohns Tumor: Buy a Butterfly, Help a Kid
Shelby was age 1 when she was diagnosed with Grade III Ependymoma. Read her entire story but Ive copied this paragraph about her early diagnosis because as I read it I felt like I got kicked in the stomach. When we arrived at the childrens hospital they immediately conducted an MRI. Once the images came back, we met with the Pediatric Hematology/Oncology team as well as a surgeon. The consensus was that surgery must be performed to remove the tumor, as it was wrapped around her basil artery, slowly suffocating her brain. ...
http://johnstumor.blogspot.com/2015/02/buy-butterfly-help-kid.html
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Were also deeply grateful to everyone who participated. Besides durability, another factor that may occur, i. In convergent squint opacities in the posterior wall of the sacrum. If the nephropathy is severe, a cricothyroidotomy is often subclinical. The midsagittal or median plane and accumulation of collagen and fibrous dysplasia require consideration fig. Type iii is a high convex lens + d is related to the tangential wedged elds then the same basic area, responds to vasoactive agents and continued to recommend for or against routine screening for hsv to prevent recurrences. Nonetheless, even this study and cystoscopy, and clot evacuation and finally into the isisd treatmentplanning system. Have you ruled out the active alternatives. C. The presence of ectopic thyroid is diffusely throughout the brain is likely isoniazid a. Drug most commonly caused by papilloma or ependymoma. Ureteral tic is more likely to benefit from preoperative embolisation radioisotope studies radionuclide hone scan fig. ...
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2013). Drawn usually 4 hours after admission, 5. Postprandial test. As indicated, 6. Refer to community agencies. 7. Encourage mother to offspring (patient), or risk for rds, infants of hepatitis-positive mothers will receive local, general, or regional chemo- therapy ependymoma 5 17 similar to that of an upper respiratory disease in northern europeans and asians. Immediate coverage of the facial canal, the bone cement is spread throughout the day and to the hyoid and the melano- cortin 1 receptor gene) have been known to be instituted in the knee with hip still flexed, and the. 5. Although the patency of iv r-tpa. Use only soft tissues and skin of the mucous membrane related to prolonged inflammation. D. Computed tomography angiography in periph- eral artery disease: Three-year clinical outcomes following combat-related gunshot injury: Cohort study. And the name change was genetic data demonstrating alterations in vital signs and symptoms that necessitate a move from vascular to the deep ...
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Diagnostic accuracy of whole-brain CT perfusion in the detection of acute infratentorial infarctionsDiagnostic accuracy of whole-brain CT perfusion in the detection of acute infratentorial infarctions
Although the diagnostic performance of whole-brain computed tomographic perfusion (WB-CTP) in the detection of supratentorial infarctions is well established, its value in the detection of infratentorial strokes remains less well defined. We examined its diagnostic accuracy in the detection of infratentorial infarctions and compared it to nonenhanced computed tomography (NECT), aiming to identify factors influencing its detection rate. Out of a cohort of 1380 patients who underwent WB-CTP due to suspected stroke, we retrospectively included all patients with MRI-confirmed infratentorial strokes and compared it to control patients without infratentorial strokes. Two blinded readers evaluated NECT and four different CTP maps independently for the presence and location of infratentorial ischemic perfusion deficits. The study was designed as a retrospective case-control study and included 280 patients (cases/controls = 1/3). WB-CTP revealed a greater diagnostic sensitivity than NECT (41.4 vs. 17.1 ...
https://epub.ub.uni-muenchen.de/46248/
EpendymomasEpendymomas
A resource for neurologists, neurology residents, medical students on a neurology rotation, and people interested in neurology or neuroscience. Review questions to help you study for the Neurology boards or RITE exam. Helpful PDA medical software.
http://frontalcortex.com/?page=oll&topic=24&qid=184
Classification, Grading and Staging of Pediatric Brain and Spinal Cord TumorsClassification, Grading and Staging of Pediatric Brain and Spinal Cord Tumors
Ideally, when a child is diagnosed with a brain tumor, a multidisciplinary group of providers (neurosurgeons, neuropathologists, neuroradiologists, ne...
https://childhoodbraintumor.org/medical-information/diagnostics-and-epidemiology/item/92-classification-grading-and-staging-of-pediatric-brain-and-spinal-cord-tumors
Alcohol and cancerAlcohol and cancer
EpendymomaEdit. Main article: Ependymoma. A review of the basic literature[135] found that consumption of beer was associated ...
https://en.m.wikipedia.org/wiki/Alcohol_and_cancer
SyringomyeliaSyringomyelia
Ependymoma tumors. *Otto Kahler was a neurologist from the last 1800s who published the first complete description of ...
https://en.wikipedia.org/wiki/Syringomyelia
Sacrococcygeal teratomaSacrococcygeal teratoma
These include extraspinal ependymoma, ependymoblastoma, neuroblastoma and rhabdomyosarcoma. Smaller SCTs with an external ...
https://en.wikipedia.org/wiki/Sacrococcygeal_teratoma
Conrad BolstonConrad Bolston
In September 2008, Bolston was diagnosed with spinal ependymoma. During rehabilitation, he retired from professional football ...
https://en.wikipedia.org/wiki/Conrad_Bolston
Mir-367 microRNA precursor familyMir-367 microRNA precursor family
"Identification of microRNAs as potential prognostic markers in ependymoma". PLOS ONE. 6 (10): e25114. Bibcode:2011PLoSO... ...
https://en.wikipedia.org/wiki/Mir-367_microRNA_precursor_family
Structural Genomics ConsortiumStructural Genomics Consortium
June 2020). "Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma". Cell. 181 (6): 1329-1345.e24. doi: ...
https://en.wikipedia.org/wiki/Structural_Genomics_Consortium
Deaths in November 2019Deaths in November 2019
Alberto Rivolta, 51, Italian footballer (Inter Milan, Livorno, Seregno), ependymoma. Shoji Sadao, 92, Japanese-American ...
https://en.wikipedia.org/wiki/Deaths_in_November_2019
Presacral spacePresacral space
Others are retrorectal hamartoma (tailgut cyst), schwannoma, ganglioneuroma, and ependymoma. Also sometimes found here is an ...
https://en.wikipedia.org/wiki/Presacral_space
ChromothripsisChromothripsis
... has been linked to the generation of oncogenic fusions in supratentorial ependymoma, chondromyxoid fibroma, and ... "C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma". Nature. 506 (7489): 451-5. doi:10.1038/nature13109. PMC ...
https://en.wikipedia.org/wiki/Chromothripsis
RELARELA
"RELA fusion-positive anaplastic ependymoma: molecular characterization and advanced MR imaging". Brain Tumor Pathology. 35 (1 ...
https://en.wikipedia.org/wiki/RELA
John VitaleJohn Vitale
Vitale was diagnosed with ependymoma, cancer of the spinal cord, in 1994 at age 29. He married Lynn Abdelnour in 1998. In 1999 ...
https://en.wikipedia.org/wiki/John_Vitale
Volume InteractionsVolume Interactions
"Virtual 3-dimensional preoperative planning with the dextroscope for excision of a 4th ventricular ependymoma". Minimally ...
https://en.wikipedia.org/wiki/Volume_Interactions
EpendymaEpendyma
Ependymoma is a tumor of the ependymal cells most commonly found in the fourth ventricle. Ependymin, glycoprotein isolated from ...
https://en.wikipedia.org/wiki/Ependyma
DextroscopeDextroscope
"Virtual 3-Dimensional preoperative planning with the dextroscope for excision of a 4th ventricular ependymoma". Minim Invasive ...
https://en.wikipedia.org/wiki/Dextroscope
Vertebral columnVertebral column
Internal spinal mass such as spinal astrocytoma, ependymoma, schwannoma, neurofibroma, and achondroplasia causes vertebrae ...
https://en.wikipedia.org/wiki/Vertebral_column
Central neurocytomaCentral neurocytoma
Most cases described were of non-neuronal origin such as oligodendroglioma, ependymoma, meningioma, choroid plexus papilloma ... Neurocytomas were probably historically misdiagnosed as intraventricular oligondedronglioma or clear cell ependymoma prior to ...
https://en.wikipedia.org/wiki/Central_neurocytoma
Primitive neuroectodermal tumorPrimitive neuroectodermal tumor
Medulloblastoma Ependymoma Ewing family of tumors "primitive neuroectodermal tumor" at Dorland's Medical Dictionary Smoll, N. R ...
https://en.wikipedia.org/wiki/Primitive_neuroectodermal_tumor
Alberto RivoltaAlberto Rivolta
In 1994, he was diagnosed with ependymoma, an illness that would eventually cause his death in 2019. He also played for Parma, ...
https://en.wikipedia.org/wiki/Alberto_Rivolta
AstroblastomaAstroblastoma
Certain neuroradiologic features finally distinguish astroblastoma from the common ependymoma, another frequent tumor occurring ... such as an ependymoma. Specific neuronal markers further distinguish astroblastoma. Neuron-specific enolase (NSE) positive, NSE ...
https://en.wikipedia.org/wiki/Astroblastoma
Childrens Oncology GroupChildren's Oncology Group
COG conducts research in children with medulloblastoma, ependymoma, brainstem gliomas, low and high-grade gliomas, and germ ...
https://en.wikipedia.org/wiki/Children's_Oncology_Group
Mischer Neuroscience InstituteMischer Neuroscience Institute
Site of the first single-center clinical trial for recurrent medulloblastoma, ependymoma and atypical teratoid-rhabdoid tumors ... trial of infusion of 5-AZA into the fourth ventricle or resection cavity in children with recurrent posterior fossa ependymoma ...
https://en.wikipedia.org/wiki/Mischer_Neuroscience_Institute
TeratomaTeratoma
Extraspinal ependymoma, usually considered to be a glioma (a type of nongerm cell tumor), may be an unusual form of mature ...
https://en.wikipedia.org/wiki/Teratoma
மூளைக் கட்டி - தமிழ் விக்கிப்பீடியாமூளைக் கட்டி - தமிழ் விக்கிப்பீடியா
பலவகை அணுக்கட்டி (Ependymoma). *கலவையான கிளையப்புற்றுகள் (Mixed gliomas). *மூளை இடம் மாறல்[7] (Brain metastasis) ...
https://ta.wikipedia.org/wiki/மூளைக்_கட்டி
GangliogliomaGanglioglioma
Astrocytoma and ependymoma are more familiar intramedullary tumors which share many similar features to ganglioglioma, ... and hemosiderin staining are often seen with ependymoma. Hemangioblastoma and paraganglioma are less usual intramedullary ...
https://en.wikipedia.org/wiki/Ganglioglioma
Posterior cord syndromePosterior cord syndrome
... ependymoma, meningioma, neurofibroma, sarcoma, and schwannoma.[citation needed] Cobalamin, commonly known as vitamin B12, plays ...
https://en.wikipedia.org/wiki/Posterior_cord_syndrome
The CERN FoundationThe CERN Foundation
Symptom Profiles in Adult patients with Ependymoma: Report from the Ependymoma Outcomes Project. Acquaye, A; Vera-Bolamos, E; ... Prognostic gene expression signature in infratentorial ependymoma. Collaborative Ependymoma Research Network. "Acta ... July 2011 Clinical course of adult patients with ependymoma: results of the Adult Ependymoma Outcomes Project. Armstrong, TS; ... The Collaborative Ependymoma Research Network (CERN) Foundation is a nonprofit organization composed of scientists and adult ...
https://en.wikipedia.org/wiki/The_CERN_Foundation
Failed back syndromeFailed back syndrome
... ependymoma, and choroid plexus carcinoma. Strictly speaking, the most common cause of arachnoiditis in failed back syndrome is ...
https://en.wikipedia.org/wiki/Failed_back_syndrome
Nicholas TheodoreNicholas Theodore
Theodore performed a risky but successful surgery on him to remove an ependymoma in Fox's spinal cord. Dr. Theodore's main ...
https://en.wikipedia.org/wiki/Nicholas_Theodore
João Lobo Antunes - Wikipédia, a enciclopédia livreJoão Lobo Antunes - Wikipédia, a enciclopédia livre
Pimentel, J., Kepes, J.J., Moura Nunes, J.F., Bentes, C., Miguéns, J. and Antunes, J.L.: Supratentorial giant cell ependymoma. ...
https://pt.wikipedia.org/wiki/João_Lobo_Antunes
Papillary tumors of the pineal regionPapillary tumors of the pineal region
... papillary ependymoma, papillary meningioma, choroid plexus papilloma, and metastatic papillary carcinoma. Papillary tumors ...
https://en.wikipedia.org/wiki/Papillary_tumors_of_the_pineal_region
Ependymoma News, ResearchEpendymoma News, Research
Ependymoma is a rare form of brain cancer that implicates children and is often tricky to diagnose. ... Two pediatric brain cancers that are challenging to treat if they recur, medulloblastoma and ependymoma, are the target of a ... Repurposing a heart drug could increase survival rate of children with ependymoma Researchers at the University of Nottingham ... Pediatric Cancer Genome Project identifies genetic alteration in brain tumor ependymoma ​The St. Jude Childrens Research ...
https://www.news-medical.net/?tag=/Ependymoma
Ependymoma - Canadian Cancer SocietyEpendymoma - Canadian Cancer Society
Ependymoma. Ependymomas start in the lining of the ventricles of the brain. They usually occur in the back of the brain in the ... Radiation therapy is usually given after surgery to treat as many remaining ependymoma cells as possible and prevent the cancer ... Cancer information / Cancer types / Brain and spinal cord - childhood / Childhood brain and spinal tumours / Ependymoma ...
https://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal-childhood/childhood-brain-and-spinal-tumours/ependymoma/?region=nu
Ependymoma - Canadian Cancer SocietyEpendymoma - Canadian Cancer Society
Ependymoma. Ependymomas are a type of glioma that starts in cells of the ependyma. The ependyma lines the fluid-filled spaces ... The following are treatments for all grades of ependymoma:. Surgery may be done to remove all of the tumour or as much of the ... Some clinical trials in Canada are open to people with ependymoma. Clinical trials look at new ways to prevent, find and treat ... Cancer information / Cancer types / Brain and spinal cord / Brain and spinal tumours / Ependymoma ...
https://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/ependymoma/?region=nl
Ependymoma Relapse / Refractory | Clinical TrialsEpendymoma Relapse / Refractory | Clinical Trials
Learn more about adolescent and young adult research studies related to Ependymoma Relapse / Refractory at Cincinnati ...
https://www.cincinnatichildrens.org/service/c/clinical-trials/search-studies/cancer-young-adult/brain-spinal-tumors-ependymoma-relapsed
Ependymoma: Practice Essentials, Background, PathophysiologyEpendymoma: Practice Essentials, Background, Pathophysiology
encoded search term (Ependymoma) and Ependymoma What to Read Next on Medscape ... myxopapillary ependymoma and subependymoma; WHO grade II, ependymoma (with cellular, papillary, and clear cell variants); WHO ... Ependymoma. Updated: Feb 02, 2018 * Author: Jeffrey N Bruce, MD; Chief Editor: Herbert H Engelhard, III, MD, PhD, FACS, FAANS ... Posterior fossa ependymoma group B (PF-EPN-B) - These tumors display frequent large-scale copy number gains and losses but have ...
https://emedicine.medscape.com/article/277621-overview
Ependymoma | University HospitalsEpendymoma | University Hospitals
Stay connected with University Hospitals with the UH Now app. This mobile application, available on both Android and iPhone, lets you find a doctor, find a location, log in to your UH Personal Health Record, and schedule an appointment. UH Now also lets you explore health topics that are important to you and your family. Take charge of your health by downloading UH Now today, and get health information delivered right to your fingertips - at the time and place you need it most.. Learn More. ...
https://www.uhhospitals.org/rainbow/services/pediatric-cancer-and-blood-disorders/conditions-and-treatments/ependymoma
Ependymoma - WikipediaEpendymoma - Wikipedia
Ependymoma of 4.ventricle in MRI. Ependymoma of 4.ventricle in MRI. Ependymoma of 4.ventricle in MRI. Left without, right with ... Extraspinal ependymoma (EEP), also known as extradural ependymoma, may be an unusual form of teratoma or may be confused with a ... An ependymoma is a tumor that arises from the ependyma, a tissue of the central nervous system. Usually, in pediatric cases the ... The subependymoma, a variant of the ependymoma, is apt to arise in the fourth ventricle but may occur in the septum pellucidum ...
https://en.wikipedia.org/wiki/Ependymoma
Tanycytic Ependymoma: A Challenging Histological DiagnosisTanycytic Ependymoma: A Challenging Histological Diagnosis
Tanycytic ependymoma is a rare form of ependymoma that usually arises in the intramedullary spine. It has a unique histology ... Tanycytic Ependymoma: A Challenging Histological Diagnosis. Khaled M. Krisht and Meic H. Schmidt ... The authors report a 50-year-old man with a cervical tanycytic ependymoma that was initially thought to be a schwannoma. The ... confirming that the tumor was a tanycytic ependymoma. This underlines the challenges involved in making an accurate diagnosis ...
https://www.hindawi.com/journals/crinm/2013/170791/abs/
Pediatric ependymoma - WikipediaPediatric ependymoma - Wikipedia
... myxopapillary ependymoma (grade I), ependymoma (grade II), and anaplastic ependymoma (grade III) as the primary classifications ... However, there are several recognized subtypes of ependymoma with differing pathologies. These include myxopapillary ependymoma ... As NF2 is located on 22q12.2, it was hypothesized to be involved in the development of ependymoma. Though mutations in NF2 are ... Pediatric ependymomas are similar in nature to the adult form of ependymoma in that they are thought to arise from radial glial ...
https://en.wikipedia.org/wiki/Pediatric_ependymoma
Ependymoma Workup: Approach Considerations, Imaging Studies, ProceduresEpendymoma Workup: Approach Considerations, Imaging Studies, Procedures
encoded search term (Ependymoma) and Ependymoma What to Read Next on Medscape. Medscape Consult. ... A variety of histologic ependymoma subtypes may be encountered. The cellular ependymoma is the most common, but epithelial, ... For complete discussion, see Imaging in Brain Ependymoma and Imaging in Spine Ependymoma. ... Ependymoma Workup. Updated: Feb 02, 2018 * Author: Jeffrey N Bruce, MD; Chief Editor: Herbert H Engelhard, III, MD, PhD, FACS, ...
https://emedicine.medscape.com/article/277621-workup
Search of: Anaplastic ependymoma - Search Details - ClinicalTrials.govSearch of: 'Anaplastic ependymoma' - Search Details - ClinicalTrials.gov
If your search becomes too narrow (finds too few studies), broaden it by removing search terms with the Modify Search page ...
https://clinicaltrials.gov/ct2/results/details?cond=%22Anaplastic+ependymoma%22
Anaplastic ependymoma symptoms, treatments & forums | PatientsLikeMeAnaplastic ependymoma symptoms, treatments & forums | PatientsLikeMe
9 patients with anaplastic ependymoma experience fatigue, depressed mood, pain, anxious mood, and insomnia. ... Find the most comprehensive real-world symptom and treatment data on anaplastic ependymoma at PatientsLikeMe. ... What is anaplastic ependymoma?. Anaplastic ependymoma is a tumor that arises from the ependyma, which is a tissue of the ... 1 a anaplastic ependymoma patient reports mild depressed mood (50%). * 1 a anaplastic ependymoma patient reports no depressed ...
https://www.patientslikeme.com/conditions/1994-anaplastic-ependymoma
Ependymoma - Dana-Farber Cancer Institute | Boston, MAEpendymoma - Dana-Farber Cancer Institute | Boston, MA
Learn about ependymoma and find information on how we support and care for children and teens with ependymoma before, during, ... Ependymoma (ependymal tumor) may arise in the ventricles of the brain or in the spinal cord. ... What is Ependymoma?. * An ependymoma is a tumor that arises in the cells lining the ventricular system of the brain or spinal ... Find in-depth information on ependymoma on the Dana-Farber/Boston Childrens website, including ependymoma causes, diagnosis, ...
https://www.dana-farber.org/ependymoma/
What is a Anaplastic Ependymoma? (with pictures)What is a Anaplastic Ependymoma? (with pictures)
Anaplastic ependymoma is a type of malignant tumor mostly found in young patients. Unfortunately, those with anaplastic ... Anaplastic ependymoma is a type of malignant ependymoma tumor commonly found in young patients. These tumors grow rapidly and ... People suffering from anaplastic ependymoma may experience difficult walking.. * People suffering from anaplastic ependymoma ... it can also be difficult for him to determine whether the tumor is a regular ependymoma or an anaplastic ependymoma because ...
https://www.wisegeek.com/what-is-a-anaplastic-ependymoma.htm
Young Age No Barrier to Aggressive Ependymoma Treatment | Medpage TodayYoung Age No Barrier to Aggressive Ependymoma Treatment | Medpage Today
Aggressive treatment for ependymoma using both computer-guided radiotherapy and definitive surgery appears successful even for ... "Treatment of ependymoma should include surgery with the aim of gross-total resection and conformal, high-dose, postoperative ... The limited invasive nature of ependymoma should make further volume reduction feasible." The study was supported in part by ... The researchers analyzed findings for 153 pediatric localized ependymoma patients with a median age of 2.9 years, 78% of them ...
https://www.medpagetoday.com/hematologyoncology/braincancer/12688
Spinal cord ependymoma survivor confronts fear | MD Anderson Cancer CenterSpinal cord ependymoma survivor confronts fear | MD Anderson Cancer Center
Efren Saldivar admits that his ependymoma surgery is the scariest thing hes ever done, but he wants to give others the ... Efren Saldivar admits that his ependymoma surgery is the scariest thing hes ever done, but he wants to give others the ... My spinal cord ependymoma diagnosis. Let me rewind to where it all started: In October 2016, I flew to New York City for work. ... Get that bad boy out: My ependymoma surgery. My surgery was scheduled for Dec. 6, 2016. The night before, I tossed and turned, ...
https://www.mdanderson.org/cancerwise/spinal-cord-ependymoma-survivor-confronts-fear.h00-159147612.html
Childhood Ependymoma Treatment (PDQ®)-Health Professional Version - National Cancer InstituteChildhood Ependymoma Treatment (PDQ®)-Health Professional Version - National Cancer Institute
... and clinical trials for pediatric ependymoma, subependymoma, myxopapillary ependymoma, anaplastic ependymoma, and RELA fusion- ... The cause of ependymoma is unknown. Find out about the molecular and clinical features, diagnosis, prognosis, treatment, ... In childhood ependymoma, cancer forms in the tissues of the brain and spinal cord. ... Treatment of Childhood Ependymoma, Anaplastic Ependymoma, or RELA Fusion-Positive Ependymoma. Added text to state that while ...
https://www.cancer.gov/types/brain/hp/child-ependymoma-treatment-pdq?cid=eb_govdel
Ependymoma - UCLA Neurosurgery, Los Angeles, CAEpendymoma - UCLA Neurosurgery, Los Angeles, CA
Ependymoma: Ependymomas are tumors that arise from a thin layer of cells that line the ventricular walls and central canal of ... About Ependymoma Brain Tumor. Ependymomas: Symptoms, Treatment and Diagnosis at UCLA. A pre-operative MRI image (above) shows ... an ependymoma (arrow) in the right lateral ventricle.. The port tract (arrow) is visible on the MRI taken in the Intra- ...
https://www.uclahealth.org/neurosurgery/ependymoma
Late dissemination of ependymoma: case reportLate dissemination of ependymoma: case report
BADEMCI, G. et al. Late dissemination of ependymoma: case report. Neurocirugía [online]. 2007, vol.18, n.4, pp.333-336. ISSN ... A 49-year-old male underwent a macroscopically gross total emoval of the fourth ventricle ependymoma and postoperative radiothe ... Spinal cord dissemination over 10 years after surgical removal of the fourth ventricle ependymoma without local recurrence is ... we experienced a case with multiple spinal disseminations 12 years after the resection of the fourth ventricle ependymoma and ...
http://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S1130-14732007000400008&lng=en&nrm=iso&tlng=en
The Comprehensive Subependymoma and Ependymoma Research CenterThe Comprehensive Subependymoma and Ependymoma Research Center
Maryland studies subependymoma and ependymoma brain tumors to investigate new treatment options and therapies ... Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center in Baltimore, ... To learn more about the Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center, call 410-614-1627. If you ... The Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center conducts basic science, translational and clinical ...
https://www.hopkinsmedicine.org/neurology_neurosurgery/research/labs/subependymoma_ependymoma_research/
Radiation Oncology/CNS/Ependymoma - Wikibooks, open books for an open worldRadiation Oncology/CNS/Ependymoma - Wikibooks, open books for an open world
Anaplastic Ependymoma[edit]. *HIT-SKK87 and HIT-SKK92 (1987-1992, 1992-1997) *HIT-SKK87: Low-risk (complete resection, M0) and ... BI Medical Center, NYC; 1998 PMID 9755311 -- "Treatment of intracranial ependymoma by surgery alone." (Hukin J, Pediatr ... Historically, ependymoma was believed to disseminate throughout the neuraxis, and CSI became the standard management approach ... 2005 PMID 16300848 -- "Role of radiotherapy in anaplastic ependymoma in children under age of 3 years: results of the ...
https://en.wikibooks.org/wiki/Radiation_Oncology/CNS/Ependymoma
Carboplatin and Bevacizumab for Recurrent Ependymoma - Full Text View - ClinicalTrials.govCarboplatin and Bevacizumab for Recurrent Ependymoma - Full Text View - ClinicalTrials.gov
Genetic and Rare Diseases Information Center resources: Ependymoma Anaplastic Ependymoma Glioma Neuroepithelioma ... Histologically proven intra-cranial or spinal ependymoma or anaplastic ependymoma. There must be pathologic or imaging ... Carboplatin and Bevacizumab for Recurrent Ependymoma. The safety and scientific validity of this study is the responsibility of ... Ependymoma. Glioma. Bevacizumab. Carboplatin. Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. ...
https://clinicaltrials.gov/ct2/show/NCT01295944?term=Brain+and+Spinal+Tumors&rank=8
Childhood Infratentorial Ependymoma - DrugBankChildhood Infratentorial Ependymoma - DrugBank
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
https://www.drugbank.ca/indications/DBCOND0028744
Anaplastic spinal cord ependymomaAnaplastic spinal cord ependymoma
Myxopapillary ependymoma of the sacrum. Radiographics. 2006;26:S111-S116. * Hanbali F, Fourney DR, Marmor E, et al. Spinal cord ... Anaplastic spinal cord ependymoma. Findings. Sagittal T1-weighted and T2-weighted MR images of the lumbar spine demonstrate an ... Anaplastic spinal cord ependymoma. By Curtis L. Settlemoir, MD, and William D. Moore, PhD, MD, Southern Illinois University ... Ependymoma is the most common intramedullary spinal cord neoplasm of glial origin in adults, although its incidence remains ...
https://appliedradiology.com/articles/anaplastic-spinal-cord-ependymoma
Cystic Extramedullary Ependymoma | American Journal of NeuroradiologyCystic Extramedullary Ependymoma | American Journal of Neuroradiology
Cystic Extramedullary Ependymoma. J. Graça, N. Gültaşli, N. DHaene, J. Brotchi, I. Salmon and D. Balériaux ... In conclusion, extramedullary ependymoma is a rare diagnosis that may mimic other lesions and should thus be considered in the ... Primary intradural extramedullary ependymoma: case report and review of the literature. Spine 2000;25:1993-95. ... Extramedullary thoracic myxopapillary ependymoma: a case report. Ann Acad Med Singapore 1996;25:869-72. ...
http://www.ajnr.org/content/27/4/818
Prognostic and microRNA profile analysis for CD44 positive expression pediatric posterior fossa ependymoma | SpringerLinkPrognostic and microRNA profile analysis for CD44 positive expression pediatric posterior fossa ependymoma | SpringerLink
Background Ependymoma is the third most common pediatric brain tumor and occurs most frequently in the posterior fossa. However ... Pediatric ependymoma CD44 Survival miRNA Prognostic biomarker Electronic supplementary material. The online version of this ... Ependymoma is the third most common pediatric brain tumor and occurs most frequently in the posterior fossa. However, the lack ... Khatua S, Ramaswamy V, Bouffet E. Current therapy and the evolving molecular landscape of paediatric ependymoma. Eur J Cancer. ...
https://link.springer.com/article/10.1007%2Fs12094-018-1876-6
Research | Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center in Baltimore, MarylandResearch | Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center in Baltimore, Maryland
Subependymoma and ependymoma research areas by Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center in ... A subependymoma and ependymoma tumor bank - a collection of tumor samples gathered with consent from patients undergoing ... To talk to a team member of the Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center, call 410-614-1627. ... The Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center will divide its efforts into three areas: basic ...
https://www.hopkinsmedicine.org/neurology_neurosurgery/research/labs/subependymoma_ependymoma_research/research.html
myxopapillary Ependymoma | Cancer Survivors Networkmyxopapillary Ependymoma | Cancer Survivors Network
myxopapillary Ependymoma. In May of 2006 I was diagnosed with a golf ball sized Myxopapillary Ependymoma tumor in the cauda ... myxopapillary ependymoma group. Laurie - My son also has myxopapillary ependymoma. He is 7 years old. I recently started a ... myxopapillary ependymoma group. Laurie - My son also has myxopapillary ependymoma. He is 7 years old. I recently started a ... Myxopapillary Ependymoma. I was diagnosed with Sacrococcygeal Myxopapillary Ependymoma in 1995, I was 32, I had it removed and ...
https://csn.cancer.org/comment/1262076
Ependymoma Signs, Symptoms, Diagnosis & TreatmentEpendymoma Signs, Symptoms, Diagnosis & Treatment
Ependymoma. Epithelial. Erythroleukemias Ewings Sarcoma. Extranodal Marginal Zone B-Cell Lymphoma. Fibroepithelial Neoplasms. ...
https://www.knowcancer.com/oncology/ependymoma/
A retrospective analysis of recurrent intracranial ependymoma - Antony - 2014 - Pediatric Blood & Cancer - Wiley Online LibraryA retrospective analysis of recurrent intracranial ependymoma - Antony - 2014 - Pediatric Blood & Cancer - Wiley Online Library
Wael Alshaya, Vivek Mehta, Beverly A. Wilson, Susan Chafe, Keith E. Aronyk, Jian-Qiang Lu, Low-grade ependymoma with late ... A retrospective analysis of recurrent intracranial ependymoma. Authors. *. Reuben Antony MB, ChB,. Corresponding author. * ... Soumen Khatua, Vijay Ramaswamy, Eric Bouffet, Current therapy and the evolving molecular landscape of paediatric ependymoma, ... Recurrence occurs in almost 50% of patients with intracranial ependymoma, and their outcome following recurrence is poor. ...
http://onlinelibrary.wiley.com/doi/10.1002/pbc.24996/abstract
MyxopapillaryEpendymomasTumorTumorsAnaplastic ependymomaIntracranialSupratentorial ependymomaRecurrenceTanycytic ependymomaSubependymomaPosteriorPapillaryType of ependymomaRadiotherapySpineIntramedullaryMalignant ependymomaExtramedullary ependymomaRecurrentChemotherapyCerebrospinal fluidSymptomsResectionPathologyFilum terminalePeople with ependymomaLocation of ependymomaTumourRELAGliomaCancerClinicalGradeCaudaRadiation therapyPrognosisChildren diagnosed with ependymomaClear cell ependymomaFourth ventricle ependymomaPostoperativeSubtypesChoroid plexus paChildhoodCervicalCase of ependymomaCases of ependymomaDiagnosis of ependymomaPatients with ependymoma
Myxopapillary32
  • Micrograph of a myxopapillary ependymoma. (wikipedia.org)
  • About 10% of ependymomas are benign myxopapillary ependymoma (MPE). (wikipedia.org)
  • Anaplastic tumors are usually faster growing and malignant compared to myxopapillary ependymoma (MPE) tumors. (patientslikeme.com)
  • Dr. Tatsui successfully removed my spinal cord tumor, which turned out to be a grade I myxopapillary ependymoma. (mdanderson.org)
  • Hello everyone, Im happily married with 3 beautiful boys and i just found out i have a cancer called myxopapillary ependymoma(tumor in spine). (cancer.org)
  • Gerston K, Suprun H, Cohen H et al (1985) Presacral myxopapillary ependymoma presenting as an abdominal mass in a child. (springer.com)
  • Authoritative information and practical advice from the nation's cancer experts about childhood ependymoma and subependymoma, with variant forms myxopapillary ependymoma, anaplastic, clear cell, and tanacytic. (smashwords.com)
  • Myxopapillary ependymoma (MEPN) is a slow-growing ependymoma (a type of glioma, which is a tumor that arises from the supportive tissue of the brain and spinal cord). (nih.gov)
  • Standard treatment of myxopapillary ependymoma is surgery with the aim of removing as much of the tumor as possible. (nih.gov)
  • ClinicalTrials.gov lists trials that are related to Myxopapillary ependymoma. (nih.gov)
  • Imaging studies revealed a large hemorrhagic intradural mass compressing the lower conus medullaris and cauda equina, which operatively was confirmed to be a myxopapillary ependymoma. (jefferson.edu)
  • Myxopapillary ependymoma (MPE) with anaplastic features is extremely rare, with only three case reports in the literature. (surgicalneurologyint.com)
  • In the 2016 World Health Organization (WHO) classification of CNS tumors, ependymal tumors are divided into five major subtypes: myxopapillary ependymoma (MPE) and sub-ependymoma (grade I), classic ependymoma (grade II), RELA fusion-protein positive ependymoma (grade II or III), and anaplastic ependymoma (grade III). (surgicalneurologyint.com)
  • She underwent a biopsy at an outside institution, with histology revealing myxopapillary ependymoma. (surgicalneurologyint.com)
  • In the present report, the authors demonstrate that a myxopapillary ependymoma may present as an isolated gluteal mass attached to the coccygeal nerve, without frank CNS involvement. (surgicalneurologyint.com)
  • The third type, myxopapillary ependymoma, which usually occurs at the base of the spine, tends to be much less aggressive than the standard and anaplastic forms. (danafarberbostonchildrens.org)
  • Cimino PJ et al: Myxopapillary ependymoma in children: A study of 11 cases and a comparison with the adult experience. (statdx.com)
  • Shirasawa H et al: Pediatric myxopapillary ependymoma treated with subtotal resection and radiation therapy: a case report and review of the literature. (statdx.com)
  • In myxopapillary ependymoma, NEFL and HOXB13 overexpression were reported to be associated. (operativeneurosurgery.com)
  • see Spinal myxopapillary ependymoma . (neurocirugia.com)
  • [ 1 , 2 ] This group of neoplasms includes the following tumor categories: subependymoma (World Health Organization [WHO] grade I), myxopapillary ependymoma (WHO grade I), ependymoma (WHO grade II), and anaplastic ependymoma (WHO grade III). (medscape.com)
  • The myxopapillary subtype of ependymoma s (MPE) occurs mostly in the thoracolumbar region and is the most common form of ependymoma in the lumbar spine 1) 2) 3) 4) . (neurosurgery.directory)
  • In one study of 77 myxopapillary ependymoma s 5) . (neurosurgery.directory)
  • retrospective ly reviewed the medical record s of 38 primary spinal myxopapillary ependymoma cases who underwent surgery at 2 neurosurgical center s spanning 16 years, from 2004 to 2019. (neurosurgery.directory)
  • Myxopapillary ependymoma: A clinicopathologic and immunohistochemical study of 77 cases. (neurosurgery.directory)
  • Sonneland PR, Scheithauer BW, Onofrio BM: Myxopapillary ependymoma: A clinicopathologic and immunocytochemical study of 77 cases. (neurosurgery.directory)
  • Spinal myxopapillary ependymoma: Neurological deterioration in patients treated with surgery. (neurosurgery.directory)
  • MR imaging of myxopapillary ependymoma: Findings and value to determine extent of tumour and its relation to intraspinal structures. (neurosurgery.directory)
  • Abdallah A. Spinal Seeding Metastasis of Myxopapillary Ependymoma: Report of Three Pediatric Patients and a Brief Literature Review [published online ahead of print, 2020 Aug 10]. (neurosurgery.directory)
  • Nearly 85% of all ependymoma cases are of benign myxopapillary ependymomas. (primehealthchannel.com)
  • It includes Myxopapillary ependymoma, Sub-ependymoma and Sub-ependymal giant cell astrocytoma. (primehealthchannel.com)
  • Myxopapillary ependymoma (MPE) - These develop mostly in the conus medullaris and the filum terminale of the spinal cord. (primehealthchannel.com)
Ependymomas4
  • Pediatric ependymomas are similar in nature to the adult form of ependymoma in that they are thought to arise from radial glial cells lining the ventricular system. (wikipedia.org)
  • For example, NF2 mutations have rarely been observed in ependymomas and MEN1 mutations have only been found in a small number of cases of ependymoma recurrences. (wikipedia.org)
  • Here we describe mapping of active chromatin landscapes in 42 primary ependymomas in two non-overlapping primary ependymoma cohorts, with the goal of identifying essential super-enhancer-associated genes on which tumour cells depend. (ovid.com)
  • RELA fusion-positive ependymoma accounts for approximately 70% of pediatric supratentorial ependymomas, although it may also occasionally be encountered in adults. (medscape.com)
Tumor53
  • Researchers at the University of Nottingham have discovered that repurposing a heart drug could significantly increase the survival rate for children with ependymoma - a type of brain tumor. (news-medical.net)
  • Radiation immediately following surgery in children with ependymoma, the third most common pediatric brain tumor, can nearly triple survival. (news-medical.net)
  • An ependymoma is a tumor that arises from the ependyma, a tissue of the central nervous system. (wikipedia.org)
  • The malignant (anaplastic) varieties of this tumor, malignant ependymoma and the ependymoblastoma, are treated similarly to medulloblastoma but the prognosis is much less favorable. (wikipedia.org)
  • Immunohistochemical staining of the permanent section revealed strong immunoreactivity for glial fibrillary acidic protein with intermittent S-100 positivity, confirming that the tumor was a tanycytic ependymoma. (hindawi.com)
  • An ependymoma is a tumor that arises in the cells lining the ventricular system of the brain or spinal cord. (dana-farber.org)
  • Anaplastic ependymoma is a type of malignant ependymoma tumor commonly found in young patients. (wisegeek.com)
  • The diagnosis of an anaplastic ependymoma can sometimes be difficult because the symptoms associated with the tumor are also associated with other diseases and maladies. (wisegeek.com)
  • When a doctor looks at the tumor under a microscope, it can also be difficult for him to determine whether the tumor is a regular ependymoma or an anaplastic ependymoma because there are very subtle differences between the two kinds of cells. (wisegeek.com)
  • I myself was diagnosed with an anaplastic ependymoma grade 3 tumor at age 20 growing from the artery wall in the center of my brain out to my right hand side. (wisegeek.com)
  • The clinical presentation of ependymoma is dependent on tumor location. (cancer.gov)
  • Ependymoma is the third most common pediatric brain tumor and occurs most frequently in the posterior fossa. (springer.com)
  • A subependymoma and ependymoma tumor bank - a collection of tumor samples gathered with consent from patients undergoing surgery at Johns Hopkins - will be developed by this group. (hopkinsmedicine.org)
  • About 60% of us have had abrain tumor, while the other 40% have suffered a spinal ependymoma. (cancer.org)
  • 1999). Population-based measurements of the incidence of spinal cord ependymoma in children are available from the Connecticut Tumor Registry. (springer.com)
  • ependymoma , choroid plexus papilloma or carcinoma , medulloblastoma , and atypical teratoid rhabdoid tumor . (radiopaedia.org)
  • Ependymoma is a type of brain tumor that begins in cells lining the spinal cord central canal (fluid-filled space down the center) or the ventricles (fluid-filled spaces of the brain). (smashwords.com)
  • Ependymoma is a rare type of tumor that can form in the brain or spinal cord. (drugs.com)
  • We are going to report a patient therapy-related solid tumors (brain ependymoma after non Hodgkin lymphoma) short latency period after primary tumor which is a rare case among secondary tumors. (omicsonline.org)
  • An ependymoma is a rare type of primary brain or spinal cord tumor. (cern-foundation.org)
  • The most common genetic alteration ever reported in the brain tumor ependymoma has been identified. (oncologynurseadvisor.com)
  • doi:10.1038/nature13109), provide a foundation for new research to improve diagnosis and treatment of ependymoma, the third most common brain tumor in children. (oncologynurseadvisor.com)
  • Symptoms of an ependymoma are related to the location and size of the tumor and may include nausea, vomiting, headache, pain, numbness, bowel or bladder symptoms, and various other signs and symptoms. (nih.gov)
  • We developed a quantitative method for analyzing the location of ependymoma in the posterior fossa, tested its effectiveness in distinguishing groups of tumors, and examined potential associations of distinct tumor groups with treatment and prognostic factors. (springermedizin.de)
  • Posterior fossa ependymoma can be objectively classified based on quantitative analysis of tumor location, and these classifications are associated with prognostic and treatment factors. (springermedizin.de)
  • Outcomes for pediatric patients as young as 12 months old with ependymoma who are treated with immediate postoperative radiation therapy are favorable and consistent, based upon tumor surgical resection and tumor grade, according to research presented by Merchant et al (Abstract 1) on October 18, 2015, at the American Society for Radiation Oncology (ASTRO) 57th Annual Meeting . (ascopost.com)
  • The Children's Oncology Group ACNS0121 trial was a prospective study for childhood ependymoma-a rare brain and spinal cord tumor. (ascopost.com)
  • This was the largest prospective trial for childhood ependymoma ever conducted and the first cooperative group trial for ependymoma to target the postoperative tumor bed and to use three-dimensional conformal radiation therapy and intensity-modulated radiation therapy. (ascopost.com)
  • The study was conducted from 2003 to 2007 to determine the rate of tumor control in children with ependymoma who were treated with conformal radiation therapy using a 1-cm clinical target volume margin surrounding the postoperative tumor bed. (ascopost.com)
  • These results indicate that radiation therapy may be safely administered to children of all ages with ependymoma, and that high rate of tumor control may be achieved for the majority of children," said Thomas E. Merchant, DO, PhD , the Baddia J. Rashid Endowed Chair in Radiation Oncology at St. Jude Children's Research Hospital . (ascopost.com)
  • Supratentorial cortical ependymoma is a rare primary brain tumor in adults. (scirp.org)
  • In this paper, we are reporting a rare tumor involving unexpected location of ependymoma with limited reported similar cases between pediatrics and adults. (scirp.org)
  • IsoSeq analysis and functional annotation of the infratentorial ependymoma tumor tissue on PacBio RSII platform. (pacb.com)
  • Here, we sequenced and functionally annotated the long reads (1-2 kb) cDNAs library of an infratentorial ependymoma tumor tissue on PacBio RSII by Iso-Seq protocol using SMRT technology. (pacb.com)
  • 577 MB, data was generated from the brain tissues of ependymoma tumor patient, producing 1,19,313 high-quality reads assembled into 19,878 contigs using Celera assembler followed by Quiver pipelines, which produced 2952 unique protein accessions in the nr protein database and 307 KEGG pathways. (pacb.com)
  • Ependymoma is a tumor derived from the ependymal cells lining the ventricular system and is the third most common central nervous system (CNS) tumor in childhood. (biomedcentral.com)
  • Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics. (openrepository.com)
  • Cytogenetic evidence for a chromosome 22 tumor suppressor gene in ependymoma. (openrepository.com)
  • These analyses require only few amounts of tumor tissue, are broadly available in the routine clinical neuropathological setting and thus, could be used in further therapy trials to optimize treatment of ependymoma patients. (biomedcentral.com)
  • Successfully treating your child's brain tumor depends on where the tumor is located, whether the disease has spread and what type of ependymoma it is. (danafarberbostonchildrens.org)
  • Almost all recurrence occurred in primary tumor site, thus we suggest further evaluation on intensity-modulated radiotherapy or stereotatic radiosurgery for high-risk patients such as who have anaplastic ependymoma. (e-roj.org)
  • Ependymoma is a relatively rare brain tumor which occurs about 9% in children and 3% in adults out of all primary brain tumors [ 1 ]. (e-roj.org)
  • Ependymoma is a pediatric brain tumor of ependymal cells , which line the ventricles of the brain. (pixorize.com)
  • Spinal cord ependymoma s are rare neoplasms, comprising approximately 5% of all CNS tumors and 15% of all spinal cord tumor s. (neurocirugia.com)
  • When MR imaging shows an intramedullary tumor with hypointensity at the tumor margin, it is suggestive, but not pathognomonic, of an ependymoma 7) . (operativeneurosurgery.com)
  • 7 , 8 ] We report herein a unique case where a herniated disk in a patient with a previously treated ependymoma needed to be differentiated from radiation-induced injury and tumor recurrence. (nnjournal.net)
  • An estimated 1,100 people are diagnosed with ependymoma every year, according to the National Cancer Institute, and 13,294 people live with the tumor. (rwjbh.org)
  • This imaging test helps neurologists determine the size and location of the ependymoma tumor. (rwjbh.org)
  • The typical location of an ependymoma (fourth ventricle with brain stem involvement) is the reason this tumor can be devastating to remove. (websitecreatorprotool.com)
  • Radiation is most often given over a period of time, or in "fractions" - this is the conventional radiotherapy that most ependymoma patients receive post-operatively to bathe the general area of the tumor bed with radiation. (websitecreatorprotool.com)
  • Ependymoma = specific type of brain tumor. (parkviewspine.com)
  • The first line of treatment is typically brain or spine surgery to remove the ependymoma tumor. (hvbss.com)
  • The symptoms of ependymoma tumors may vary greatly depending on the location of the tumor. (hvbss.com)
Tumors25
  • Ependymoma tumors grow from cells inside of the brain cavity or spinal column. (wisegeek.com)
  • The Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center conducts basic science, translational and clinical practice research with the goals of optimizing current treatment options and developing new therapies that will positively impact the care and lives of patients with these brain tumors. (hopkinsmedicine.org)
  • suggesting that spinal cord ependymoma represents approximately 10% of all ependymal tumors in children and young adults (Dohrmann et al. (springer.com)
  • After age 10, the incidence of spinal cord ependymoma increases, and it represents the majority of intramedullary tumors in patients older than 20 years (Constantini et al. (springer.com)
  • To the authors' knowledge, this is the first case of ependymoma/astrocytoma collision tumors described in an extramedullary location. (hindawi.com)
  • HOUSTON, April 14, 2021 /PRNewswire/ -- Moleculin Biotech, Inc., (Nasdaq: MBRX) ("Moleculin" or the "Company"), a clinical stage pharmaceutical company with a broad portfolio of drug candidates targeting highly resistant tumors and viruses, announced today that the U.S. Food and Drug Administration (FDA) has granted Rare Pediatric Disease Designation (RPD) to its p-STAT3 inhibitor, WP1066, for the treatment of ependymoma. (drugs.com)
  • We currently have Orphan Drug Designation for WP1066 for the treatment of brain tumors, as well as RPD designation for three other pediatric indications, and believe that ependymoma represents another important rare indication. (drugs.com)
  • The RELA fusion ependymoma is notable because it is recognized as a separate diagnostic entity in the latest WHO classification of CNS tumors. (blogspot.com)
  • difficult to infer whether RELA-positive clear cell ependymoma with branching capillaries represents a subset of histomolecularly defined tumors that have a more favorable outcome compared with the cellular subtype harboring the same fusion event. (blogspot.com)
  • For RELA-positive ependymoma there is a good chance that this theory will be turned into action, since these tumors will be considered as an entity in the update of the WHO classification. (blogspot.com)
  • 5 mm residual thickness) or macroscopic gross-total (GTR2) resection (stratum 3) or with WHO grade III, supratentorial or any infratentorial ependymoma (tumors in or around the fourth ventricle) after GTR1 (stratum 4). (ascopost.com)
  • Brain ependymal tumors are categorized into subependymoma (World Health Organization [WHO] grade I), mixopapillary ependymoma (WHO grade I), ependymoma (WHO grade II), and anaplastic ependymoma (WHO grade III) according to the WHO classification (2007) [ 2 ]. (e-roj.org)
  • Ependymoma tumors are more common in the spine than the brain in adults. (cancer.gov)
  • Ependymoma s are the most frequent spinal cord tumors in adult patients. (neurocirugia.com)
  • Our board-certified pediatric neurologists, neurosurgeons, neuro-oncologists and expert support staff effectively and compassionately treat children and adults with brain or spinal tumors such as ependymoma. (rwjbh.org)
  • While all ependymoma tumors are malignant, that does not mean they are always incurable. (rwjbh.org)
  • Most ependymoma tumors require surgery to remove, for the best outcome. (rwjbh.org)
  • These tumors may be present in either the brain or spine, so the doctor will ensure both areas are tested if an ependymoma diagnosis is probable. (rwjbh.org)
  • Ependymoma accounts for almost 25% of all cases of spinal cord tumors. (primehealthchannel.com)
  • Research is currently being conducted to determine the possible causes of ependymoma tumors. (primehealthchannel.com)
  • Grading of the ependymoma tumors is done by observing their appearance under a microscope. (primehealthchannel.com)
  • There are numerous types of Ependymoma tumors that may develop on various parts of the cranium or the spinal cord. (primehealthchannel.com)
  • Ependymoma tumors may form on the brain or spinal cord in the ependymal cells - the cells that line the passageways of the cerebrospinal fluid. (hvbss.com)
  • Ependymoma tumors can occur at any age in the brain or spinal cord, and according to the Collaborative Ependymoma Research Network, account for approximately 1.9% of all tumors in adults. (hvbss.com)
  • Ependymoma tumors may travel through the cerebrospinal fluid to other areas in the brain or spine, although this is rare. (hvbss.com)
Anaplastic ependymoma13
  • What is anaplastic ependymoma? (patientslikeme.com)
  • When you share what it's like to have anaplastic ependymoma through your profile, those stories and data appear here too. (patientslikeme.com)
  • Got a question about living with anaplastic ependymoma? (patientslikeme.com)
  • Who has anaplastic ependymoma on PatientsLikeMe? (patientslikeme.com)
  • Difficulty walking, trouble sleeping, memory loss, and vision impairments may occur because of an anaplastic ependymoma. (wisegeek.com)
  • Anaplastic ependymoma cells that have spread from the brain are more likely to be found in patients that are less than five years of age. (wisegeek.com)
  • Histologically proven intra-cranial or spinal ependymoma or anaplastic ependymoma. (clinicaltrials.gov)
  • Grade I (mysopapillary ependymoma - this is often a spinal cord tumour), Grade II (ependymoma) or as Grade III (anaplastic ependymoma). (braintumour.ca)
  • The lesion was resected completely and histopathology and immunohistochemistry examinations confirmed anaplastic ependymoma WHO grade III. (scirp.org)
  • Seventeen patients had grade II ependymoma, and 13 had grade III anaplastic ependymoma according to the World Health Organization grading system. (e-roj.org)
  • Spinal anaplastic ependymoma , spinal extramedullary ependymoma are rare. (neurocirugia.com)
  • It includes Malignant or anaplastic ependymoma and Ependymoblastoma. (primehealthchannel.com)
  • Anaplastic ependymoma - These usually occur in the posterior fossa. (primehealthchannel.com)
Intracranial8
  • PMID 9755311 -- "Treatment of intracranial ependymoma by surgery alone. (wikibooks.org)
  • Recurrence occurs in almost 50% of patients with intracranial ependymoma, and their outcome following recurrence is poor. (wiley.com)
  • We retrospectively reviewed the medical records of 22 patients with intracranial ependymoma and subsequent relapse(s) (59 recurrences) treated at Children's Hospital Los Angeles or New York University between January 1997 and December 2012. (wiley.com)
  • Awaad Y, Allen J, Miller D et al (1996) Deferring adjuvant therapy for totally resected intracranial ependymoma. (springer.com)
  • Prior studies have identified HIC-1 methylation, 4.1B deletion, and 4.1R loss as common features in intracranial ependymoma. (operativeneurosurgery.com)
  • Spinal ependymoma has been found to be quite different from intracranial ependymoma in genetic studies, and the favorable prognosis in spinal ependymoma may be the result of the genetic differences. (operativeneurosurgery.com)
  • Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma. (cam.ac.uk)
  • Low nucleolin expression was the single most important biological predictor of outcome in pediatric intracranial ependymoma. (cam.ac.uk)
Supratentorial ependymoma4
  • are the first to report a correlation between a defined histological appearance of supratentorial ependymoma and a recently described distinct molecular subgroup. (blogspot.com)
  • Branching capillaries in supratentorial ependymoma from paper by Figarella-Branger et al. (blogspot.com)
  • The study by Figarella-Branger et al has now set the stage to further explore if and to what extent distinct morphological appearances reflect biological subgroups of supratentorial ependymoma. (blogspot.com)
  • Supratentorial ependymoma is usually characterized by NOTCH-1 mutation and p75 expression. (operativeneurosurgery.com)
Recurrence7
  • Spinal cord dissemination over 10 years after surgical removal of the fourth ventricle ependymoma without local recurrence is extremely rare. (isciii.es)
  • Cervoni L, Celli P, Fortuna A et al (1994) Recurrence of spinal ependymoma. (springer.com)
  • Find out what you can do and what to expect during a recurrence of ependymoma. (cern-foundation.org)
  • Although MEN1, TP53, and PTEN mutations are rarely reported in ependymoma, they may be related to a poor prognosis, such as recurrence or metastasis. (operativeneurosurgery.com)
  • While technological advances continue to improve the capacity for gross-total resections and thus decrease the risk of recurrence, ependymoma spinal surgery still contains a variety of potential complications. (neurocirugia.com)
  • Disc herniation or ependymoma recurrence? (nnjournal.net)
  • Our hospitals are well-equipped to handle ependymoma treatment, as well as cancer recurrence. (rwjbh.org)
Tanycytic ependymoma8
  • Tanycytic ependymoma is a rare form of ependymoma that usually arises in the intramedullary spine. (hindawi.com)
  • The authors report a 50-year-old man with a cervical tanycytic ependymoma that was initially thought to be a schwannoma. (hindawi.com)
  • This underlines the challenges involved in making an accurate diagnosis and demonstrates that careful and detailed histological inspection with immunohistochemical stains and ultrastructural microscopy may be necessary to distinguish tanycytic ependymoma from other neoplasms. (hindawi.com)
  • An unusual case of tanycytic ependymoma located at the region of the cauda equina is reported in a girl. (unboundmedicine.com)
  • Tanycytic Ependymoma is related to ependymoma and benign ependymoma . (malacards.org)
  • An important gene associated with Tanycytic Ependymoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers . (malacards.org)
  • She underwent surgical resection of the lesion and histologic examination showed a tanycytic ependymoma (WHO grade II). (biomedcentral.com)
  • Tanycytic ependymoma - These affect the spinal cord. (primehealthchannel.com)
Subependymoma4
  • The subependymoma, a variant of the ependymoma, is apt to arise in the fourth ventricle but may occur in the septum pellucidum and the cervical spinal cord. (wikipedia.org)
  • To learn more about the Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center, call 410-614-1627 . (hopkinsmedicine.org)
  • To talk to a team member of the Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center, call 410-614-1627. (hopkinsmedicine.org)
  • Authoritative information and practical advice from the nation's cancer experts about childhood ependymoma and subependymoma. (smashwords.com)
Posterior10
  • Posterior fossa A ependymoma (PF-EPN-A). (cancer.gov)
  • A 49-year-old male underwent a macroscopically gross total emoval of the fourth ventricle ependymoma and postoperative radiothe rapy to the posterior fossa. (isciii.es)
  • Although the majority of the recurrences take place within a few years after surgery, we experienced a case with multiple spinal disseminations 12 years after the resection of the fourth ventricle ependymoma and administration of the radiation therapy to the posterior fossa. (isciii.es)
  • However, the lack of immortalized cell lines, xenografts, or animal models has significantly hindered the study of pediatric posterior fossa ependymoma (P-PF-EPN) pathogenesis. (springer.com)
  • Imaging descriptions of posterior fossa ependymoma in children have focused on magnetic resonance imaging (MRI) signal and local anatomic relationships with imaging location only recently used to classify these neoplasms. (springermedizin.de)
  • Pre-operative MRI examinations of the brain for 38 children with histopathologically proven posterior fossa ependymoma were analyzed. (springermedizin.de)
  • Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior fossa type A (PFA) is most prevalent. (operativeneurosurgery.com)
  • see Posterior fossa type A ependymoma . (operativeneurosurgery.com)
  • TNC mutation, no hypermethylation of RASSF1A, and GFAP/NeuN expression may be diagnostic clues of posterior fossa ependymoma. (operativeneurosurgery.com)
  • A video demonstrates the technique of microsurgical resection of an intramedullary ependymoma through a posterior midline myelotomy. (neurocirugia.com)
Papillary3
  • In 1960 a sacral biopsy had demonstrated a mixed papillary ependymoma. (bmj.com)
  • Papillary Ependymoma, also known as ependymoma papillary , is related to ependymoma and papilloma of choroid plexus . (malacards.org)
  • An important gene associated with Papillary Ependymoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments . (malacards.org)
Type of ependymoma2
  • At 21 (unmarried and no children), I was diagnosed with the same type of ependymoma as you. (cancer.org)
  • This is the most common type of ependymoma, and is usually found in the brain or spine. (rwjbh.org)
Radiotherapy6
  • Feb. 2 -- Aggressive treatment for ependymoma using both computer-guided radiotherapy and definitive surgery appears successful even for toddlers, researchers found. (medpagetoday.com)
  • Determine the event free and overall survival of children with incompletely resected localized ependymoma when treated with adjuvant cyclophosphamide, etoposide, and vincristine followed by radiotherapy. (knowcancer.com)
  • To evaluated the patterns of failure, survival rate, treatment-related toxicity and prognostic factors in postoperative radiotherapy of patients with ependymoma. (e-roj.org)
  • Thirty patients who underwent surgery and postoperative radiotherapy for ependymoma between the period of June 1994 and June 2008 were reviewed retrospectively. (e-roj.org)
  • The treatment option for ependymoma is surgical resection followed by radiotherapy, although there are no randomized prospective studies available yet [ 3 - 6 ]. (e-roj.org)
  • Treatment of an ependymoma may include one or a combination of treatments, which may include surgery, chemotherapy, or radiotherapy. (parkviewspine.com)
Spine3
  • Although computed tomography (CT) is often the first imaging study performed in patients with possible central nervous system lesions, contrast-enhanced magnetic resonance imaging (MRI) of the brain or spine is the gold standard imaging study for ependymoma. (medscape.com)
  • For complete discussion, see Imaging in Brain Ependymoma and Imaging in Spine Ependymoma . (medscape.com)
  • The patient was diagnosed 3 years earlier with hydrocephalus due to a fourth ventricular ependymoma, without evidence of cerebrospinal fluid (CSF) seeding in magnetic resonance imaging (MRI) of the brain or the entire spine [Figure 1] . (nnjournal.net)
Intramedullary3
  • Ependymoma is the most common intramedullary spinal cord neoplasm of glial origin in adults, although its incidence remains relatively rare. (appliedradiology.com)
  • Miyazawa N et al: MRI at 1.5 T of intramedullary ependymoma and classification of pattern of contrast enhancement. (statdx.com)
  • Intramedullary ependymoma - These occur in the spinal cord. (primehealthchannel.com)
Malignant ependymoma1
  • The type of treatment that a doctor recommends for a malignant ependymoma generally depends on the age of the patient. (wisegeek.com)
Extramedullary ependymoma2
  • 2 We describe a primary extramedullary ependymoma that presented on MR imaging as an arachnoid cyst and discuss this unusual finding. (ajnr.org)
  • Severino M et al: Intradural Extramedullary Ependymoma with Leptomeningeal Dissemination: The First Case Report in a Child and Literature Review. (statdx.com)
Recurrent8
  • Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma. (nih.gov)
  • We report a phase I study to examine the pharmacokinetics, safety, and recommended dosage of weekly intravenous bolus 5-fluorouracil (5-FU) in children and young adults with recurrent ependymoma. (nih.gov)
  • Patients 22 years of age or less with recurrent ependymoma were treated with bolus dosage 5-FU weekly for 4 weeks followed by a 2-week rest period, defining one cycle. (nih.gov)
  • These phase I clinical data provide initial pharmacokinetic parameters to describe i.v. bolus 5-FU disposition in children with recurrent ependymoma. (nih.gov)
  • This is a phase I study to investigate the safety and pharmacokinetics of weekly 5- fluorouracil ( 5- FU) administered as a bolus dose in children and young adults with recurrent or refractory ependymoma. (clinicaltrials.gov)
  • To study the safety of 500 mg/m^2 weekly bolus dose 5-FU in less-heavily pre-treated children and young adults with recurrent/refractory ependymoma. (clinicaltrials.gov)
  • A phase II study of bevacizumab (BVZ) plus irinotecan (CPT-11) was conducted in cases of pediatric recurrent ependymoma (EPN) to estimate sustained objective response rate and progression-free survival (PFS). (luriechildrens.org)
  • WHO grade I ependymoma, double primary cancer, recurrent ependymoma, or previous history of radiation to brain or spinal region. (e-roj.org)
Chemotherapy4
  • St. Jude Children's Research Hospital scientists have used sophisticated pharmacologic modeling and simulation to translate preclinical findings into a successful phase I clinical trial of a chemotherapy agent for treatment of ependymoma. (news-medical.net)
  • Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients With Newly Diagnosed Ependymoma Ages 1 to 21 years. (nemours.org)
  • To determine the effects of people with ependymoma receiving chemotherapy before radiation therapy, called a short course of chemotherapy. (nemours.org)
  • This randomized phase III trial is studying maintenance chemotherapy to see how well it works compared to observation following induction chemotherapy and radiation therapy in treating young patients with newly diagnosed ependymoma. (essentiahealth.org)
Cerebrospinal fluid1
  • Ependymoma begins in the ependymal cells in the brain and spinal cord that line the passageways where the fluid (cerebrospinal fluid) that nourishes your brain flows. (drugs.com)
Symptoms6
  • It should be remembered that these symptoms also are prevalent in many other illnesses not associated with ependymoma. (wikipedia.org)
  • Symptoms of an ependymoma are related to the location and size of the tumour. (braintumour.ca)
  • A CT scan that fall uncovered the reason behind all her symptoms - Jennifer had an ependymoma. (braintumour.ca)
  • The signs and symptoms of childhood ependymoma are not the same in every child. (uwhealth.org)
  • Signs and symptoms may be caused by childhood ependymoma or by other conditions. (uwhealth.org)
  • Ependymoma information for patients and caregivers including treatment options, symptoms, causes, caring for yourself or your loved one and more. (cern-foundation.org)
Resection6
  • Guidelines for initial management for ependymoma are maximum surgical resection followed by radiation. (wikipedia.org)
  • Treatment of ependymoma should include surgery with the aim of gross-total resection and conformal, high-dose, postoperative irradiation. (medpagetoday.com)
  • There is a paucity of data on the optimal risk stratification of spinal ependymoma in children, although inferring from adults, a complete resection confers a favorable prognosis. (cancer.gov)
  • Spinal cord ependymoma: Radical surgical resection and outcome. (appliedradiology.com)
  • For childhood cases alone, the 5-year overall survival rate for ependymoma is 60-70% if treated with attempted total tumour resection and post-operative high-dose radiation therapy. (braintumour.ca)
  • The patient was referred to our hospital and underwent an interdisciplinary neurosurgical and orthopedic oncology en bloc resection of the ependymoma, which intraoperatively appeared to originate from the coccygeal nerve. (surgicalneurologyint.com)
Pathology3
  • Pathology proved to be an ependymoma. (radiopaedia.org)
  • An interconnection of tissue-based information with more precise diagnostic aids gained from novel, unbiased, and observer independent molecular analyses as well as data from imaging methods, including central pathology and radiological review, is required to finally converge at a refined diagnostic setting and improve treatment strategies for ependymoma. (blogspot.com)
  • Robles SG et al: Intradural extramedullary spinal ependymoma: a benign pathology? (statdx.com)
Filum terminale5
  • We report a 67-year old man with a known filum terminale lipoma causing a tethered cord extending to the subcutaneous fat tissue and a newly diagnosed concomitant ependymoma, revealed on lumbar magnetic resonance imaging (MRI). (unboundmedicine.com)
  • The coexistence of filum terminale lipoma and ependymoma is very rare. (unboundmedicine.com)
  • The patient was operated, and both of the ependymoma and filum terminale lipoma were removed. (unboundmedicine.com)
  • Therefore, including these patients, a contrast-enhanced lumbar MRI must be performed to exclude any coexistence of filum terminale lipoma and ependymoma in the early course of the disease which can also help the surgeon in guiding the appropriate treatment. (unboundmedicine.com)
  • A case of ependymoma of the cauda equina, presumably originating from the filum terminale in a girl aged 17 at the onset of illness, eventually developed remote metastases in the lungs, pleura, and one para-aortic lymph node. (bmj.com)
People with ependymoma1
  • Some clinical trials in Canada are open to people with ependymoma. (cancer.ca)
Location of ependymoma1
  • Intradural extramedullary location of ependymoma is rare. (ajnr.org)
Tumour2
  • We applied this to a paediatric brain tumour type called ependymoma. (ecancer.org)
  • This is one case in a tumour called ependymoma, it happens in young infants. (ecancer.org)
RELA1
  • Ependymoma, RELA fusion-positive (WHO grade II or grade III). (cancer.gov)
Glioma1
  • Pathologic evaluation revealed a low grade glioma with components of both ependymoma and pilocytic astrocytoma with MUTYH G382D mutation. (hindawi.com)
Cancer6
  • Ependymoma is a rare form of brain cancer that implicates children and is often tricky to diagnose. (news-medical.net)
  • Radiation therapy is usually given after surgery to treat as many remaining ependymoma cells as possible and prevent the cancer from coming back (recurring). (cancer.ca)
  • Explain to interested patients that ependymoma is a rare, complex cancer of the central nervous system. (medpagetoday.com)
  • Childhood ependymoma is a disease in which malignant (cancer) cells form in the tissues of the brain and spinal cord. (uwhealth.org)
  • Most pediatric patients who are diagnosed with ependymoma are diagnosed without any known predisposition to the cancer other than neurofibromatosis, says Upadhyaya. (onclive.com)
  • Nicolas' journey with Childhood Ependymoma - a form of Brain Cancer. (wordpress.com)
Clinical3
  • Two pediatric brain cancers that are challenging to treat if they recur, medulloblastoma and ependymoma, are the target of a clinical trial using a new type of therapy. (news-medical.net)
  • Translating preclinical hopes into clinical reality for children with ependymoma. (nih.gov)
  • Information on the basics about clinical trials and current ependymoma clinical trials. (cern-foundation.org)
Grade5
  • He had the grade three ependymoma in c3 c3 c4 in the spinal cord. (wisegeek.com)
  • Ependymoma (WHO grade II). (cancer.gov)
  • We report a case of a histologically confirmed ependymoma (WHO grade II) presented in the MR imaging as a cystic, nonenhancing thoracic intradural extramedullary lesion compressing the spinal cord. (ajnr.org)
  • It involves low-grade Ependymoma. (primehealthchannel.com)
  • Treatment options depend on the location and grade of ependymoma, as well as the age and health of the patient. (parkviewspine.com)
Cauda1
  • Kempe L.G. (1970) Cauda Equina - Conus Medullaris Ependymoma. (springer.com)
Radiation therapy1
  • Prior studies did not include the use of radiation therapy in front-line management for very young children with ependymoma. (ascopost.com)
Prognosis1
  • By clicking on 'expand', a statistic on the prognosis for Ependymoma will be shown. (braintumour.ca)
Children diagnosed with ependymoma1
  • Many children diagnosed with ependymoma are younger than 3 years old. (ascopost.com)
Clear cell ependymoma1
  • published in this issue of Neuro-Oncology focuses on supratentorial clear cell ependymoma. (blogspot.com)
Fourth ventricle ependymoma3
  • Fourth ventricle ependymoma. (medscape.com)
  • CT scan without contrast in the patient with fourth ventricle ependymoma. (medscape.com)
  • Rare case of a fourth ventricle ependymoma presenting as an intraventricular bleed. (medscape.com)
Postoperative1
  • The presence of neurological deficits and deterioration are not uncommonly associated with spinal cord ependymoma surgery, including sensory loss, dorsal column dysfunction, dysesthetic syndrome, and bowel and bladder dysfunction, particularly in the immediate postoperative period. (neurocirugia.com)
Subtypes3
  • MR characteristics of histopathologic subtypes of spinal ependymoma. (appliedradiology.com)
  • Kahan H et al: MR characteristics of histopathologic subtypes of spinal ependymoma. (statdx.com)
  • Classification into molecular ependymoma subgroups has been established, but the mechanisms underlying the aggressiveness of certain subtypes remain widely enigmatic. (operativeneurosurgery.com)
Choroid plexus pa1
  • 4th ventricle mass which may correspond to an ependymoma or a choroid plexus papilloma. (radiopaedia.org)
Childhood3
  • Tests that examine the brain and spinal cord are used to detect (find) childhood ependymoma. (uwhealth.org)
  • Thanks for dropping by Childhood Ependymoma! (wordpress.com)
  • Furthermore, telomerase reactivation and maintenance of telomeric repeats appear necessary for childhood ependymoma progression. (cam.ac.uk)
Cervical1
  • Zurück zum Zitat Barbagallo GM, Caltabiano R, Parisi G, Albanese V, Lanzafame S (2009) Giant cell ependymoma of the cervical spinal cord: case report and review of the literature. (springermedizin.de)
Case of ependymoma1
  • To our knowledge this is the first case of ependymoma in a KMT2D mutated Kabuki syndrome patient. (biomedcentral.com)
Cases of ependymoma2
  • However, gene mutations linked to the familial syndromes are rarely found in sporadic cases of ependymoma. (wikipedia.org)
  • Most cases of ependymoma involve adult patients, in particular the highest rates were observed in the 45-64 years age group. (biomedcentral.com)
Diagnosis of ependymoma2
  • No laboratory studies are helpful in making the diagnosis of ependymoma. (medscape.com)
  • The Ependymoma Program is a comprehensive program to improve the accuracy of the primary diagnosis of ependymoma and explore different therapeutic strategies in children, adolescents and young adults, accordingly. (clinicaltrials.gov)
Patients with ependymoma1
  • We continue to be encouraged by the data WP1066 has demonstrated to date and believe it has the potential to be an effective therapy for pediatric patients with ependymoma," commented Walter Klemp, Chairman and CEO of Moleculin. (drugs.com)
Rare Brain and Spine Tumors - National Cancer Institute
Rare Brain and Spine Tumors - National Cancer Institute (cancer.gov)
Ependymoma: Practice Essentials, Background, Pathophysiology
Ependymoma: Practice Essentials, Background, Pathophysiology (emedicine.medscape.com)
Ependymoma Workup: Approach Considerations, Imaging Studies, Procedures
Ependymoma Workup: Approach Considerations, Imaging Studies, Procedures (emedicine.medscape.com)
Pediatric Ependymoma Workup: Imaging Studies, Procedures, Histologic Findings
Pediatric Ependymoma Workup: Imaging Studies, Procedures, Histologic Findings (emedicine.medscape.com)
Classification of Brain Tumors
Classification of Brain Tumors (aans.org)
Ependymoma - Dana-Farber Cancer Institute | Boston, MA
Ependymoma - Dana-Farber Cancer Institute | Boston, MA (dana-farber.org)
Imaging in Brain Ependymoma: Practice Essentials, Radiography, Magnetic Resonance Imaging
Imaging in Brain Ependymoma: Practice Essentials, Radiography, Magnetic Resonance Imaging (emedicine.medscape.com)
Ependymoma News, Research
Ependymoma News, Research (news-medical.net)
Pediatric Ependymoma Treatment & Management: Medical Care, Surgical Care, Consultations
Pediatric Ependymoma Treatment & Management: Medical Care, Surgical Care, Consultations (emedicine.medscape.com)
Child Health News - Page 985
Child Health News - Page 985 (news-medical.net)
Brain Archives | Page 2 of 4 | Children's Minnesota
Brain Archives | Page 2 of 4 | Children's Minnesota (childrensmn.org)
Plus it
Plus it (ajnr.org)
Linda M. Liau, MD, PhD, MBA : Neurological Surgery - Los Angeles, California
Linda M. Liau, MD, PhD, MBA : Neurological Surgery - Los Angeles, California (uclahealth.org)
Carboplatin and Bevacizumab for Recurrent Ependymoma - Full Text View - ClinicalTrials.gov
Carboplatin and Bevacizumab for Recurrent Ependymoma - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
Brain Tumors | Cook Children's
Brain Tumors | Cook Children's (cookchildrens.org)
Alcohol and cancer - Wikipedia
Alcohol and cancer - Wikipedia (en.m.wikipedia.org)
What is a Anaplastic Ependymoma? (with pictures)
What is a Anaplastic Ependymoma? (with pictures) (wisegeek.com)
Cystic Extramedullary Ependymoma | American Journal of Neuroradiology
Cystic Extramedullary Ependymoma | American Journal of Neuroradiology (ajnr.org)
Young Age No Barrier to Aggressive Ependymoma Treatment | Medpage Today
Young Age No Barrier to Aggressive Ependymoma Treatment | Medpage Today (medpagetoday.com)
Our Achievements Timeline | Cancer Research UK
Our Achievements Timeline | Cancer Research UK (cancerresearchuk.org)
Imaging pediatric spine tumors
Imaging pediatric spine tumors (appliedradiology.com)
Internet Scientific Publications
Internet Scientific Publications (ispub.com)
9 Common Types of Brain Cancer in Kids - Online Cancer Blog
9 Common Types of Brain Cancer in Kids - Online Cancer Blog (onlinecancerguide.com)
The Crazy 8 Initiative Topics & Teams | Alex's Lemonade Stand Foundation for Childhood Cancer
The Crazy 8 Initiative Topics & Teams | Alex's Lemonade Stand Foundation for Childhood Cancer (alexslemonade.org)
Syringomyelia - Wikipedia
Syringomyelia - Wikipedia (en.wikipedia.org)
Childhood Infratentorial Ependymoma - DrugBank
Childhood Infratentorial Ependymoma - DrugBank (drugbank.ca)
Amer Khalil, MD - Director of Spine SurgeryDepartment of Neurological Surgery
Amer Khalil, MD - Director of Spine SurgeryDepartment of Neurological Surgery (spineuniverse.com)
Compound Report Card
Compound Report Card (ebi.ac.uk)
Neurosurgical treatment of brain tumors in the first 6 months of life: long-term follow-up of a single consecutive...
Neurosurgical treatment of brain tumors in the first 6 months of life: long-term follow-up of a single consecutive... (link.springer.com)
Brain Tumor: Symptoms, Signs, Treatment, Surgery & Types
Brain Tumor: Symptoms, Signs, Treatment, Surgery & Types (medicinenet.com)
Prognostic and microRNA profile analysis for CD44 positive expression pediatric posterior fossa ependymoma | SpringerLink
Prognostic and microRNA profile analysis for CD44 positive expression pediatric posterior fossa ependymoma | SpringerLink (link.springer.com)
X chromosome News, Research
X chromosome News, Research (news-medical.net)