Abnormal increase of EOSINOPHILS in the blood, tissues or organs.
A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells.
A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.
A heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of EOSINOPHILS in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
A CC-type chemokine that is specific for CCR3 RECEPTORS. It is a potent chemoattractant for EOSINOPHILS.
Cytotaxins liberated from normal or invading cells that specifically attract eosinophils; they may be complement fragments, lymphokines, neutrophil products, histamine or other; the best known is the tetrapeptide ECF-A, released mainly by mast cells.
Infection by round worms of the genus TOXOCARA, usually found in wild and domesticated cats and dogs and foxes, except for the larvae, which may produce visceral and ocular larva migrans in man.
Chronic ESOPHAGITIS characterized by esophageal mucosal EOSINOPHILIA. It is diagnosed when an increase in EOSINOPHILS are present over the entire esophagus. The reflux symptoms fail to respond to PROTON PUMP INHIBITORS treatment, unlike in GASTROESOPHAGEAL REFLUX DISEASE. The symptoms are associated with IgE-mediated hypersensitivity to food or inhalant allergens.
Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
A species of parasitic nematode found in the intestine of dogs. Lesions in the brain, liver, eye, kidney, and lung are caused by migrating larvae. In humans, these larvae do not follow normal patterns and may produce visceral larva migrans (LARVA MIGRANS, VISCERAL).
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A 66-kDa peroxidase found in EOSINOPHIL granules. Eosinophil peroxidase is a cationic protein with a pI of 10.8 and is comprised of a heavy chain subunit and a light chain subunit. It possesses cytotoxic activity towards BACTERIA and other organisms, which is attributed to its peroxidase activity.
Proteins found in EOSINOPHIL granules. They are primarily basic proteins that play a role in host defense and the proinflammatory actions of activated eosinophils.
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
A CC-type chemokine with specificity for CCR3 RECEPTORS. It is a chemoattractant for EOSINOPHILS.
Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.
Infections with nematodes of the order STRONGYLIDA.
An infection with TRICHINELLA. It is caused by eating raw or undercooked meat that is infected with larvae of nematode worms TRICHINELLA genus. All members of the TRICHINELLA genus can infect human in addition to TRICHINELLA SPIRALIS, the traditional etiological agent. It is distributed throughout much of the world and is re-emerging in some parts as a public health hazard and a food safety problem.
A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils.
Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.
A 19-kDa cationic peptide found in EOSINOPHIL granules. Eosinophil-derived neurotoxin is a RIBONUCLEASE and may play a role as an endogenous antiviral agent.
Infection with nematodes of the genus STRONGYLOIDES. The presence of larvae may produce pneumonitis and the presence of adult worms in the intestine could lead to moderate to severe diarrhea.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Vaccines or candidate vaccines used to prevent infection with RESPIRATORY SYNCYTIAL VIRUSES.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.
The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.
A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)
Infections of the lungs with parasites, most commonly by parasitic worms (HELMINTHS).
Opportunistic fungal infection by a member of ALTERNARIA genus.
Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.
A genus of ascarid nematodes commonly parasitic in the intestines of cats and dogs.
Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.
A genus of parasitic nematodes widely distributed as intestinal parasites of mammals.
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
Delivery of medications through the nasal mucosa.
A genus of nematodes of the superfamily ASCARIDOIDEA whose species usually inhabit the intestine.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A condition produced in man by the prolonged migration of animal nematode larvae in extraintestinal tissues other than skin; characterized by persistent hypereosinophilia, hepatomegaly, and frequently pneumonitis, commonly caused by Toxocara canis and Toxocara cati.
Infection with TREMATODA of the genus PARAGONIMUS.
Immunoglobulins produced in a response to HELMINTH ANTIGENS.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Disordered formation of various types of leukocytes or an abnormal accumulation or deficiency of these cells.
A heterogenous group of disorders characterized by the abnormal increase of MAST CELLS in only the skin (MASTOCYTOSIS, CUTANEOUS), in extracutaneous tissues involving multiple organs (MASTOCYTOSIS, SYSTEMIC), or in solid tumors (MASTOCYTOMA).
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Blocking of a blood vessel by CHOLESTEROL-rich atheromatous deposits, generally occurring in the flow from a large artery to small arterial branches. It is also called arterial-arterial embolization or atheroembolism which may be spontaneous or iatrogenic. Patients with spontaneous atheroembolism often have painful, cyanotic digits of acute onset.
A genus of tapeworm, containing several species, found as adults in birds and mammals. The larvae or cysticercoid stage develop in invertebrates. Human infection has been reported and is probably acquired from eating inadequately cooked meat of animals infected with the second larval stage known as the tetrahythridium.
A characteristic symptom complex.
A genus of intestinal nematode parasites belonging to the superfamily HELIGMOSOMATOIDEA, which commonly occurs in rats but has been experimentally transmitted to other rodents and rabbits. Infection is usually through the skin.
Severe drug eruption characterized by high fever, erythematous rash and inflammation of internal organ(s).
CCR receptors with specificity for CHEMOKINE CCL11 and a variety of other CC CHEMOKINES. They are expressed at high levels in T-LYMPHOCYTES; EOSINOPHILS; BASOPHILS; and MAST CELLS.
The most benign and common form of Langerhans-cell histiocytosis which involves localized nodular lesions predominantly of the bones but also of the gastric mucosa, small intestine, lungs, or skin, with infiltration by EOSINOPHILS.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
Infections by nematodes, general or unspecified.
Infections or infestations with parasitic organisms. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.
Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
Phthalic acid anhydrides. Can be substituted on any carbon atom. Used extensively in industry and as a reagent in the acylation of amino- and hydroxyl groups.
Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.
Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.
A group of viruses in the PNEUMOVIRUS genus causing respiratory infections in various mammals. Humans and cattle are most affected but infections in goats and sheep have also been reported.
Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.
The presence of parasites in food and food products. For the presence of bacteria, viruses, and fungi in food, FOOD MICROBIOLOGY is available.
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
A glandular epithelial cell or a unicellular gland. Goblet cells secrete MUCUS. They are scattered in the epithelial linings of many organs, especially the SMALL INTESTINE and the RESPIRATORY TRACT.
Methylmaleic anhydrides.
INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
A genus of parasitic nematodes that occurs in mammals including man. Infection in humans is either by larvae penetrating the skin or by ingestion of uncooked fish.
Infections with nematodes of the genus GNATHOSTOMA, superfamily THELAZIOIDEA. Gnathostomiasis is a food-borne zoonosis caused by eating undercooked or raw fish or meat.
A species of parasitic nematodes distributed throughout the Pacific islands that infests the lungs of domestic rats. Human infection, caused by consumption of raw slugs and land snails, results in eosinophilic meningitis.
The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.
Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
A multifunctional cytokine secreted by primarily by activated TH2 CELLS that may play a role as a regulator of allergic INFLAMMATION. It has been shown to enhance the growth and CELL DIFFERENTIATION of MAST CELLS, and can act on a variety of other immune cells.
Substances that reduce or suppress INFLAMMATION.
One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil major basic protein is a 14-kDa cytotoxic peptide with a pI of 10.9. In addition to its direct cytotoxic effects, it stimulates the release of variety of INFLAMMATION MEDIATORS.
Pathological processes involving any part of the LUNG.
A superfamily of nematodes of the order ENOPLIDA. Its organisms have a well developed intestine and rectum.
Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
Infestation with parasitic worms of the helminth class.
INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.
Substances that are recognized by the immune system and induce an immune reaction.
Agents causing the narrowing of the lumen of a bronchus or bronchiole.

Toxic oil syndrome mortality: the first 13 years. (1/1319)

BACKGROUND: The toxic oil syndrome (TOS) epidemic that occurred in Spain in the spring of 1981 caused approximately 20000 cases of a new illness. Overall mortality and mortality by cause in this cohort through 1994 are described for the first time in this report. METHODS: We contacted, via mail or telephone, almost every living member of the cohort and family members of those who were known to have died in order to identify all deaths from 1 May 1981 through 31 December 1994. Cause of death data were collected from death certificates and underlying causes of death were coded using the International Classification of Diseases, 9th Revision. RESULTS: We identified 1663 deaths between 1 May 1981 and 31 December 1994 among 19 754 TOS cohort members, for a crude mortality rate of 8.4%. Mortality was highest during 1981, with a standardized mortality ratio (SMR) of 4.92 (95% confidence interval [CI]: 4.39-5.50) compared with the Spanish population as a whole. The highest SMR, (20.41, 95% CI: 15.97-25.71) was seen among women aged 20-39 years during the period from 1 May 1981 through 31 December 1982. Women <40 years old, who were affected by TOS , were at greater risk for death in most time periods than their unaffected peers, while older women and men were not. Over the follow-up period, mortality of the cohort was less than expected when compared with mortality of the general Spanish population, or with mortality of the population of the 14 provinces where the epidemic occurred. We also found that, except for deaths attributed to external causes including TOS and deaths due to pulmonary hypertension, all causes of death were decreased in TOS patients compared to the Spanish population. The most frequent underlying causes of death were TOS, 350 (21.1%); circulatory disorders, 536 (32.3%); and malignancies, 310 (18.7%). CONCLUSIONS: We conclude that while on average people affected by toxic oil syndrome are not at greater risk for death over the 13-year study period than any of the comparison groups, women <40 years old were at greater risk of death.  (+info)

Eotaxin contributes to renal interstitial eosinophilia. (2/1319)

BACKGROUND: A potent eosinophil chemotactic cytokine, human eotaxin, is directly chemotactic for eosinophils. Therefore, the specific expression of eotaxin in tissue might play a crucial role in tissue eosinophilia. However, the precise molecular mechanism of the recruitment and activation of eosinophils in human renal diseases remains to be investigated. We evaluated the role of eotaxin in the pathogenesis of human diffuse interstitial nephritis with marked infiltration of eosinophils. METHODS: In this study, we examined 20 healthy volunteers. 56 patients with primary or secondary glomerular diseases and two hypereosinophilic syndrome patients without renal involvement. Urinary and serum eotaxin levels were determined by an enzyme-linked immunosorbent assay. We also detected the presence of eotaxin protein immunohistochemically. RESULTS: On the one hand, urinary levels of eotaxin were significantly higher before the initiation of glucocorticoid administration in the patient with interstitial nephritis with marked infiltration of eosinophils. On the other hand, urinary eotaxin levels were not detected in any patients with nephrotic syndrome, interstitial nephritis without eosinophils, hypereosinophilic syndrome without renal involvement or other renal diseases. Serum eotaxin levels were not detected in any of the patients. Therefore, the detection of eotaxin in the urine was specific for renal interstitial eosinophilia. Moreover, endothelial cells, infiltrating mononuclear cells and renal epithelial cells in the tubulointerstitial lesions were immunostained with specific anti-eotaxin antibodies. Furthermore, the elevated urinary levels of eotaxin decreased dramatically during glucocorticoid-induced convalescence. HYPOTHESIS: We hypothesize that in situ expression of eotaxin may provide a new mechanism to explain the renal interstitial eosinophil infiltration.  (+info)

A case of eosinophilic myocarditis complicated by Kimura's disease (eosinophilic hyperplastic lymphogranuloma) and erythroderma. (3/1319)

This report describes a patient with eosinophilic myocarditis complicated by Kimura's disease (eosinophilic hyperplastic lymphogranuloma) and erythroderma. A 50-year-old man presented with a complaint of precordial pain. However, the only abnormal finding on examinatioin was eosinophilia (1617 eosinophils/microl). Three years later, the patient developed chronic eczema, and was diagnosed with erythroderma posteczematosa. One year later, a tumor was detected in the right auricule, and a diagnosis of Kimura's disease was made, based on the biopsy findings. The patient developed progressive dyspnea 6 months later and was found to have cardiomegaly and a depressed left ventricular ejection fraction (17%). A diagnosis of eosinophilic myocarditis was made based on the results of a right ventricular endomyocardial biopsy. The eosinophilic myocarditis and erythrodrema were treated with steroids with improvement of both the eosinophilia and left ventricular function.  (+info)

Differential chemokine expression in tissues involved by Hodgkin's disease: direct correlation of eotaxin expression and tissue eosinophilia. (4/1319)

Hodgkin's disease (HD) is a lymphoid malignancy characterized by infrequent malignant cells surrounded by abundant inflammatory cells. In this study, we examined the potential contribution of chemokines to inflammatory cell recruitment in different subtypes of HD. Chemokines are small proteins that are active as chemoattractants and regulators of cell activation. We found that HD tissues generally express higher levels of interferon-gamma-inducible protein-10 (IP-10), Mig, RANTES, macrophage inflammatory protein-1alpha (MIP-1alpha), and eotaxin, but not macrophage-derived chemotactic factor (MDC), than tissues from lymphoid hyperplasia (LH). Within HD subtypes, expression of IP-10 and Mig was highest in the mixed cellularity (MC) subtype, whereas expression of eotaxin and MDC was highest in the nodular sclerosis (NS) subtype. A significant direct correlation was detected between evidence of Epstein-Barr virus (EBV) infection in the neoplastic cells and levels of expression of IP-10, RANTES, and MIP-1alpha. Levels of eotaxin expression correlated directly with the extent of tissue eosinophilia. By immunohistochemistry, IP-10, Mig, and eotaxin proteins localized in the malignant Reed-Sternberg (RS) cells and their variants, and to some surrounding inflammatory cells. Eotaxin was also detected in fibroblasts and smooth muscle cells of vessels. These results provide evidence of high level chemokine expression in HD tissues and suggest that chemokines may play an important role in the recruitment of inflammatory cell infiltrates into tissues involved by HD.  (+info)

Treatment with interleukin-2 (IL-2) and interferon (IFN(alpha 2b)) after autologous bone marrow or peripheral blood stem cell transplantation in onco-hematological malignancies with a high risk of relapse. (5/1319)

Nine patients with onco-hematological malignancies with a poor prognosis due to high risk of relapse received immunotherapy with interleukin-2 (IL-2) and interferon (IFN(alpha 2b)) s.c. as maintenance therapy after receiving autologous bone marrow or peripheral blood stem cell transplantation (ABMT/PBSCT). All the patients were considered at very high risk of relapse. We attempted to assess the efficiency, toxicity and clinical effects of these cytokines in these patients. Five patients were treated with high-dose of IL-2 and the other four patients with escalating doses every month. Side-effects in the first group of patients consisted of fever, chills, weakness, nausea, anorexia, loss of weight and local dermatitis in the injection site. Toxicity on the WHO scale was grade II in three patients and grade IV in the other two patients. In the second group of patients, the same clinical signs of toxicity appeared, but these were grade I on the WHO scale in all patients. None of the patients had infections or died in relation to administration of IL-2. Four patients died of relapse or progression of their hematological malignancies. The other five patients are alive, one in chronic phase of CML and the other four patients are in complete remission of their malignancies.  (+info)

CD8 T cells are essential in the development of respiratory syncytial virus-induced lung eosinophilia and airway hyperresponsiveness. (6/1319)

Viral respiratory infections can cause bronchial hyperresponsiveness and exacerbate asthma. In mice, respiratory syncytial virus (RSV) infection results in airway hyperresponsiveness (AHR) and eosinophil influx into the airways. The immune cell requirements for these responses to RSV infection are not well defined. To delineate the role of CD8 T cells in the development of RSV-induced AHR and lung eosinophilia, we tested the ability of mice depleted of CD8 T cells to develop these symptoms of RSV infection. BALB/c mice were depleted of CD8 T cells using anti-CD8 Ab treatment before intranasal administration of infectious RSV. Six days postinfection, airway responsiveness to inhaled methacholine was assessed by barometric body plethysmography, and numbers of lung eosinophils and levels of IFN-gamma, IL-4, and IL-5 in bronchoalveolar lavage fluid were monitored. RSV infection resulted in airway eosinophilia and AHR in control mice, but not in CD8-depleted animals. Further, whereas RSV-infected mice secreted increased amounts of IL-5 into the airways as compared with noninfected controls, no IL-5 was detectable in both bronchoalveolar lavage fluid and culture supernatants from CD8-depleted animals. Treatment of CD8-depleted mice with IL-5 fully restored both lung eosinophilia and AHR. We conclude that CD8 T cells are essential for the influx of eosinophils into the lung and the development of AHR in response to RSV infection.  (+info)

Poverty and eosinophilia are risk factors for endomyocardial fibrosis (EMF) in Uganda. (7/1319)

OBJECTIVE: To determine the relative risks of socio-demographic, dietary, and environmental factors for endomyocardial fibrosis (EMF) in Uganda. METHOD: Unmatched case control study in Mulago Hospital, Kampala. Cases (n = 61) were sequential patients hospitalized with an echocardiographic diagnosis of EMF from June 1995 to March 1996. Controls (n = 120) were concurrent patients with other forms of heart disease (heart controls, n = 59) and subjects admitted for trauma or elective surgery (hospital controls, n = 61). All consenting subjects answered a structured questionnaire administered by trained interviewers. Complete blood counts, malaria films and stool examination for ova and parasites were performed. Questionnaires elicited information on home address, economic circumstances, variables concerned with environmental exposures and usual diet before becoming ill. RESULTS: After adjustment for age and sex, cases were significantly more likely than controls to have Rwanda/Burundi ethnic origins (P = 0.008). Compared with controls, cases had a lower level of education (P < 0.001 for heart controls and P = 0.07 for hospital controls), were more likely to be peasants (P < 0.001), and to come from Luwero or Mukono Districts (P = 0.003). After further adjustment for peasant occupation, cases were more likely than controls to walk barefoot (P = 0.015), consume cassava as their staple food (P < 0.001) and to lack fish or meat in dietary sauces (P = 0.02). Cases were more likely to exhibit absolute eosinophilia (P = 0.006). The effect of cassava diet was more marked in the younger age group, while the effect of eosinophilia was greater in adults. Socio-economic disadvantage is a risk for EMF. Absolute eosinophilia is a putative cause of EMF, a finding not explained by parasitism. CONCLUSION: Data indicate that relative poverty and environmental factors triggering eosinophilia appear to act in a geographically restricted region of Uganda in the aetiology of EMF.  (+info)

An adoptive transfer model of allergic lung inflammation in mice is mediated by CD4+CD62LlowCD25+ T cells. (8/1319)

Animal models of allergic lung inflammation have provided important insight into the cellular and biochemical factors involved in the pathogenesis of human asthma. Herein, we describe an adoptive transfer model of OVA-specific eosinophilic lung inflammation in the mouse that is used to characterize the cells involved in mediating the pulmonary inflammatory response. We report that freshly isolated spleen cells from OVA-sensitized mice are unable to prime naive recipient mice to respond to a subsequent OVA aerosol challenge. Subjecting the spleen cells to short term restimulation with Ag in vitro, however, renders the cells competent to transfer activity. The magnitude and the kinetics of the eosinophilic pulmonary inflammation in the adoptive transfer recipients are nearly identical with those generated by a more conventional active sensitization/challenge protocol, with the notable exception of differential production of plasma IgE in the two models. Extensive negative and positive selection of splenocyte subtypes indicates that the transfer of Ag-primed CD4+ T cells is both necessary and sufficient to establish full responsiveness in the recipient mice. Additional phenotypic characterization of the transfer-reactive CD4+ T cells indicates that they are found within the CD62LlowCD25+ subset and secrete high levels of IL-5 in response to Ag stimulation. Limiting dilution analysis-derived minimal frequency estimates indicate that approximately 1 in 8500 of the sensitized, cultured spleen cells produces IL-5 in response to OVA stimulation in vitro, suggesting that eosinophilic lung inflammation can be induced in naive mice by the transfer of <1200 Ag-specific CD4+ T cells.  (+info)

Synonyms for Eosinophilic gastroenteritis in Free Thesaurus. Antonyms for Eosinophilic gastroenteritis. 2 synonyms for gastroenteritis: intestinal flu, stomach flu. What are synonyms for Eosinophilic gastroenteritis?
TY - JOUR. T1 - Peripheral eosinophilia in the diagnosis of chronic rhinosinusitis. AU - Bhattacharyya, Neil. AU - Fried, Marvin P.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - Purpose: To determine the relationship between peripheral blood eosinophilia and chronic rhinosinusitis. Materials and Methods: A retrospective review was conducted of consecutive operative cases during 1 calendar year. The preoperative complete blood count (CBC) were tabulated for three groups of patients: Those undergoing endoscopic sinus surgery, those undergoing septoplasty with turbinate reduction alone, and a nonrhinologic control group. Statistical analysis was performed to determine differences in the components of the CBC among these three groups of patients and to identify significant associations between abnormal peripheral eosinophil counts and these diagnoses. Results: A total of 87, 32, and 92 patients were identified for the endoscopic sinus surgery (ESS), septoplasty, and control groups, respectively. Significant ...
The purpose of this study was to quantify peripheral eosinophil count and percentage of eosinophils in white blood cell (WBC) count of the patients with chronic rhinosinusitis (CRS) and look for the correlation between the CT scores and peripheral eosinophilia. Peripheral eosinophil counts and the percentages of eosinophils in white blood cell count (WBC) were statistically compared with CT scores in chronic rhinosinusitis (CRS) patients. We also statistically analyzed the peripheral eosinophil counts and the percentages of eosinophils in WBC counts between CRS patients and healthy ones. We found significant difference between CRS group and control group for peripheral eosinophil count, and percentage of eosinophils in WBC count (p=0.001 and p<0.001) respectively. We observed no correlation between CT scores and both peripheral eosinophil counts, or percentages of eosinophils in WBC counts (p=0.067and p=0.051) respectively. Although eosinophil seems as the dominator cell of CRS patients in ...
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Yen on causes of eosinophilic gastroenteritis: It is a viral infection of the GI tract. It can be picked up from contact with surfaces, foods, living things, etc. That are carrying the virus. The best prevention is frequent hand washing and proper food preparation. for topic: Causes Of Eosinophilic Gastroenteritis
Eosinophilia (e-o-sin-o-FILL-e-uh) is a higher than normal level of eosinophils. Eosinophils are a type of disease-fighting white blood cell. This condition most often indicates a parasitic infection, an allergic reaction or cancer.. You can have high levels of eosinophils in your blood (blood eosinophilia) or in tissues at the site of an infection or inflammation (tissue eosinophilia).. Tissue eosinophilia may be found in samples taken during an exploratory procedure or in samples of certain fluids, such as mucus released from nasal tissues. If you have tissue eosinophilia, the level of eosinophils in your bloodstream is likely normal.. Blood eosinophilia may be detected with a blood test, usually as part of a complete blood count. A count of more than 500 eosinophils per microliter of blood is generally considered eosinophilia in adults. A count of more than 1,500 eosinophils per microliter of blood that lasts for several months is called hypereosinophilia.. Eosinophils play two roles in your ...
Interleukin (IL)-9 is a Th2-derived cytokine with pleiotropic biological effects, which recently has been proposed as a candidate gene for asthma and allergy. We aimed to evaluate the therapeutic effect of a neutralizing anti-IL-9 antibody in a mouse model of airway eosinophilic inflammation and compared any such effect with anti-IL-5 treatment. OVA-sensitized Balb/c mice were intraperitoneally pretreated with a single dose (100 μg) of an anti-mouse IL-9 monoclonal antibody (clone D9302C12) or its vehicle. A third group was given 50 μg of a monoclonal anti-mouse IL-5 antibody (TRFK-5) or its vehicle. Animals were subsequently exposed to OVA on five days via airways. Newly produced eosinophils were labelled using 5-bromo-2-deoxyuridine (BrdU). BrdU+ eosinophils and CD34+ cell numbers were examined by immunocytochemistry. After culture and stimulation with OVA or PMA+IC, intracellular staining of IL-9 in bone marrow cells from OVA-exposed animals was measured by Flow Cytometry. The Mann-Whitney U-test
Hodgkin lymphoma (Hodgkins disease) often elicits severe eosinophilia; however, non-Hodgkin lymphoma and leukemia produce less marked eosinophilia.[3] Of solid tumor neoplasms, ovarian cancer is most likely to provoke eosinophilia, though any other cancer can cause the condition.[3] Solid epithelial cell tumors have been shown to cause both tissue and blood eosinophilia, with some reports indicating that this may be mediated by interleukin production by tumor cells, especially IL-5 or IL-3.[2] This has also been shown to occur in Hodgkin lymphoma, in the form of IL-5 secreted by Reed-Sternberg cells.[2] In primary cutaneous T cell lymphoma, blood and dermal eosinophilia are often seen. Lymphoma cells have also been shown to produce IL-5 in these disorders. Other types of lymphoid malignancies have been associated with eosinophilia, as in lymphoblastic leukemia with a translocation between chromosomes 5 and 14 or alterations in the genes which encode platelet-derived growth factor receptors ...
Sudhir Kumar Vujhini1 Indira Velagandla2, Hari Shanker Vallakati3, Mahesh Kumar Kandukuri4, Kishori D5, Swetha6. 1Assosciate professor, 2Professor and Head, 3Professor, 4Asst. Professor, 5Asst. Professor, 6Asst. Professor, Dept. of Pathology, Malla Reddy Institute of Medical Sciences, Suraram, Hyderabad, Andhra Pradesh.. Dear Sir,. Eosinophilic Gastroenteritis (EG) is a rare inflammatory disorder of gastrointestinal tract of unknown etiology. It is characterized by eosinophilic infiltration of bowel wall from esophagus to rectum, most commonly, the stomach and duodenum, peripheral eosinophilia and various gastrointestinal manifestations. Diagnosis requires a high index of suspicion and exclusion of various disorders that are associated with peripheral eosinophilia.. We report a rare case of a 36-year-old man presented with mild upper abdominal pain, tenesmus and frequency of bowel motion. The patient had no past history of ulcer pain and had not had any abdominal operations. There was no history ...
Symptoms of the following disorders can be similar to those of eosinophilic gastroenteritis. Comparisons may be useful for a differential diagnosis:. Whipples disease is an uncommon digestive disorder of microbial origin that affects the lining of the small intestine and results in malabsorption of nutrients. This disorder may also affect other organs of the body. (For more information on this disorder, choose Whipple as your search term in the Rare Disease Database.). Refractory celiac disease is a chronic intestinal malabsorption disorder caused by intolerance to gluten, an insoluble component of wheat and other grains. Clinical and/or histologic improvement of symptoms follows withdrawal of dietary gluten-containing grains. (For more information on this disorder, choose refractory celiac disease as your search term in the Rare Disease Database.). Mastocytosis is a genetic disorder characterized by abnormal accumulations of a particular type of cell (mast cells) normally found in ...
Eosinophilic gastroenteritis (EGE) is a rarely reported condition of ferrets. This article reviews three cases of suspected EGE in ferrets, summarizes the presenting signs, differential diagnoses, and treatment options, and discusses some question raised by this disease in ferrets. Immune suppression by means of prednisolone therapy is currently the treatment of choice.
Eosinophilic gastroenteritis in dogs is an inflammatory condition of the stomach and intestines, which often leads to vomiting and diarrhea in the dog.
Eosinophilic gastroenteritis in cats is a type of inflammatory intestinal and stomach disease involving white blood cells. - Wag! (formerly Vetary)
Eosinophilic gastroenteritis (EG) is a rare disease that includes a spectrum of clinical presentations, characterized by eosinophilic gastrointestinal infiltration in the..
A child with eosinophilic gastroenteritis (EGE) has high levels of a certain white blood cell in the GI tract and bloodstream. Learn more from the experts at Childrens Health.
Introduction. Posaconazole is a triazole antifungal that is used in the treatment of a variety of fungal infections, as well as in the management of mucormycosis (on an off-label basis). Eosinophilia associated with exposure to azole antifungals has been described rarely in the literature. Case presentation. A 31-year-old male on peritoneal dialysis (PD) for end-stage renal disease, secondary to diabetic nephropathy, presented to hospital with abdominal pain after a trip to St Lucia. He was taken to the operating room, where the PD catheter was removed and an abdominal-wall abscess was debrided. R hizopus species was recovered on culture of the abdominal-wall tissue, and the patient was started on amphotericin B deoxycholate. He was subsequently stepped down to posaconazole, for a planned treatment duration of 12 months. Approximately 43 days after the initiation of posaconazole, it was noted that his peripheral eosinophil count started to rise. No other cause for the eosinophilia was identified.
Tropical (pulmonary) eosinophilia, or TPE, is characterized by coughing, asthmatic attacks, and an enlarged spleen, and is caused by Wuchereria bancrofti, a filarial infection. It occurs most frequently in India and Southeast Asia. Tropical eosinophilia is considered a manifestation of a species of microfilaria. This disease can be confused with tuberculosis, asthma, or coughs related to roundworms. Tropical pulmonary eosinophilia is a rare, but well recognised, syndrome characterised by pulmonary interstitial infiltrates and marked peripheral eosinophilia. This condition is more widely recognised and promptly diagnosed in filariasis-endemic regions, such as the Indian subcontinent, Africa, Asia and South America. In nonendemic countries, patients are commonly thought to have bronchial asthma. Chronic symptoms may delay the diagnosis by up to five years. Early recognition and treatment with the antifilarial drug, diethylcarbamazine, is important, as delay before treatment may lead to progressive ...
An abnormally high number of eosinophils in the blood. Normally, eosinophils constitute 1 to 3% of the peripheral blood leukocytes, at a count of 350 to 650 per cubic millimeter. Eosinophilia can be categorized as mild (less than 1500 eosinophils per cubic millimeter), moderate (1500 to 5000 per cubic millimeter), or severe (more than 5000 per cubic millimeter). In areas of the world where parasitic diseases are common, they are the usual cause of eosinophilia. In developed nations, eosinophilia is most often due to allergy or, less often, a drug reaction. There are numerous other causes of eosinophilia, but individually they are quite uncommon. Eosinophilia may be primary or secondary. In primary eosinophilia, the increased production of eosinophils is due to an abnormality in a hematopoietic stem cell as, for example, in eosinophilic leukemia. In secondary eosinophilia, the increased production of eosinophils is a reactive process driven by cytokines, as is the case in allergy. ...
Subjects admitted on this protocol will have elevated eosinophil counts in the peripheral blood or tissues or will be relatives of subjects with eosinophilia. Eosinophilic subjects will undergo an extensive clinical evaluation focused on the identification of the cause of eosinophilia and the presence of end organ manifestations. In addition, they will be characterized in detail immunologically, and their blood cells and/or serum will be collected to provide reagents (eg. specific antibodies, T-cell clones, etc.) that will be used in the laboratory to address broader questions relating to the etiology of eosinophilia, its immunoregulation, the degree and source of eosinophil activation, and/or the functional role of eosinophils in the afferent arm of those immune response where they are prominent. While the protocol is not primarily designed to study treatment of patients with blood and tissue eosinophilia, the clinical and immunological responses to various medically indicated therapies will be ...
It has been shown that a management strategy that aims to minimise eosinophilic airway inflammation and symptoms is associated with a significant reduction in the frequency of COPD exacerbations requiring hospital admission. The majority of this benefit occurred in patients with significant eosinophilic airway inflammation. The management strategy was associated with no overall increase in the use of inhaled or oral corticosteroids, although there was evidence that increased corticosteroid therapy was targeted to patients with eosinophilic airway inflammation in the intervention group. No difference was observed in the frequency of mild, self-managed exacerbations or in the frequency of moderate exacerbations requiring GP or unscheduled clinic review.. The present findings suggest an association between eosinophilic airway inflammation and severe exacerbations of COPD. This interpretation is consistent with earlier work identifying increased eosinophilic airway inflammation at the time of a COPD ...
This group is for parents who have children with an eosinophilic disorder such as eosinophilic gastroenteritis (EG), eosinophilic esophagitis (EE), and eosinophilic colitis (EC). These conditions involve severe food allergies and often require the use of elemental formula as supplements or the sole source of nutrition. A great website for information about eosinophilic disorders is www.apfed.org.
Eosinophilia. Merck Manual Professional Version website. Available at: https://www.merckmanuals.com/professional/hematology-and-oncology/eosinophilic-disorders/eosinophilia. Updated November 2016. Accessed July 13, 2018.. Eosinophilia. Patient website. Available at: https://patient.info/doctor/eosinophilia. Updated March 12, 2014. Accessed July 13, 2018.. Eosinophilia-approach to the patient. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T917758/Eosinophilia-approach-to-the-patient . Updated June 5, 2017. Accessed July 13, 2018. Tefferi A. Blood eosinophilia: a new paradigm in disease classification, diagnosis, and treatment.. Mayo Clin Proc. 2005;80(1):75-83.. ...
We present a unique case of vancomycin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome masquerading as elusive endocarditis. A 37-year-old female actively using intravenous drugs presented with worsening right upper extremity pain, fever, and chills. Workup revealed methicillin-resistant staphylococcus aureus (MRSA) bacteremia and multiple right-sided septic pulmonary emboli. Echocardiogram was negative for vegetation. Vancomycin was initiated for bacteremia management suspected secondary to right upper extremity abscesses. However, despite resolution of abscesses, fevers persisted, raising suspicion for endocarditis not detected by echocardiogram. On hospital day 25, the patient began showing signs of DRESS syndrome, ultimately manifesting as transaminitis, eosinophilia, and a diffuse, maculopapular rash. Vancomycin was switched to Linezolid and she improved on high dose steroids. The persistent fevers throughout this hospital course were thought to be an elusive
TY - JOUR. T1 - Role of IL-5 in IL-2-induced eosinophilia. In vivo and in vitro expression of IL-5 mRNA by IL-2. AU - Yamaguchi, Y.. AU - Suda, T.. AU - Shiozaki, H.. AU - Miura, Y.. AU - Hitoshi, Y.. AU - Tominaga, A.. AU - Takatsu, K.. AU - Kasahara, T.. PY - 1990/1/1. Y1 - 1990/1/1. N2 - We recently demonstrated in vivo that IL-5 was an important mediator of eosinophilia in mice with parasite infections. In this study, we examined whether or not IL-5 was actually responsible for the eosinophilia induced by injection of human IL-2. Mice administered hIL-2 developed eosinophilia during the course of the series of injections. This eosinophilia could be suppressed by a single injection of mAb against murine IL-5. The number of eosinophilic precursors increased more in the spleen cells of the IL-2-treated mice in comparison to the control mice, although in bone marrow precursors showed little change. Similarly, the number of granulocytic precursors increased markedly in the spleen cells of ...
Eosinophilia is common in child years, and generally it really is mild and of small clinical relevance, getting secondary to allergy or infections often. most cases it really is light and transient, but could possibly be the first indication of the severe pathological condition occasionally. Hypereosinophilia is thought as a peripheral bloodstream absolute eosinophil count number (AEC) greater than 0.6109/L (0.7109/L in neonates).1,2 The amount of eosinophilia could be additional categorized into mild (AEC 0.6-1.5109/L), moderate (AEC 1.5-5109/L), or serious (AEC >5109/L).3 Eosinophilia could be principal (idiopathic) or supplementary to allergy, infections, connective tissues disease, or cancers. While light eosinophilia is frequent in childhood, becoming most commonly related to allergy, 1 moderate and severe eosinophilia is definitely rare. Usually, children with sensitive diathesis show slight to moderate eosinophilia, with AEC hardly Rabbit polyclonal to Smac. ever exceeding 1.0-2.0109/L. ...
Eosinophilic Gastroenteritis Eosinophilic gastroenteritis (EGE) is a rare disease in which a type of white blood cell, the eosinophil, causes injury and
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Eosinophilia is a common finding in returning travellers and migrants, and in this group it often indicates an underlying helminth infection. Infections are frequently either asymptomatic or associated with non-specific symptoms, but some can cause severe disease. Here the British Infection Society guidelines group reviews common and serious infectious causes of eosinophilia, and outlines a scheme for investigating returning travellers and migrants. All returning travellers and migrants with eosinophilia should be investigated with concentrated stool microscopy and strongyloides serology, in addition to tests specific to the region they have visited. Terminal urine microscopy and serology for schistosomiasis should also be performed in those returning from Africa. Eosinophilia is also a feature of significant non-infective conditions, which should be considered.
TY - JOUR. T1 - Malignant lymphoma with eosinophilia of the gastrointestinal tract. AU - Shepherd, N.A.. AU - Blackshaw, A. J.. AU - Hall, P.A.. AU - Bostad, L.. AU - Coates, P. J.. AU - Lowe, D. G.. AU - Levison, D A. AU - Morson, B. C.. AU - Stansfeld, A. G.. PY - 1987. Y1 - 1987. N2 - Lesions of the gastrointestinal tract with massive tissue eosinophilia may present a difficult diagnostic problem. In a series of 250 gastrointestinal lymphomas drawn from the files of St Bartholomews and St Marks Hospitals there were 28 cases of a lymphoma with distinctive histological features, characterized by a massive tissue eosinophilia. Two of these tumours were present in the stomach and 26 in the small intestine. Eight of the latter were associated with coeliac disease. On low power examination a zoning phenomenon was regularly seen and fissuring ulceration, with perforation and fistula formation, was a common finding. The tumour cells were large and pleomorphic with irregular nuclear morphology and ...
In this study we have examined repeatedly at different time points the anti-inflammatory effects of fluticasone and montelukast on the airway eosinophilic inflammation of subjects with steroid naive asthma. The results show that treatment with fluticasone suppresses sputum eosinophils and significantly improves FEV1. These effects of fluticasone were observed by 7 days and were maintained during the 8 weeks of the study. Treatment with montelukast attenuated and had its greatest effect on airway eosinophilia by day 7. However, in contrast to fluticasone, the effect only lasted 4 weeks. In addition, montelukast had no effect on FEV1. Placebo treatment did not affect sputum eosinophilia or improve FEV1. These results are relevant to the treatment of asthma with sputum eosinophilia in patients who are not receiving inhaled steroids, but not to similar patients without sputum eosinophilia.. This is the first study to compare repeatedly at several time points the anti-inflammatory effects of a low ...
The condition in which the eosinophil count in the peripheral blood gets increased is termed as Eosinophilia.. Eosinophils are white blood cells that are responsible for combating multi cellular parasites and certain infections in vertebrates, they also control mechanisms associated with allergy and asthma.. These Eosinophils also known as granulocytes are developed during haematopoiesis (the formation of blood cellular components) in the bone marrow before migrating into the blood.. On an average 5% - 7% of the white blood cells constitute of the Eosinophils, a higher count of which is an outcome of the disease Eosinophilia.. Eosinophilia is kind of bronchitis which causes an inflammation of the airways and results in blockage, cough and difficulty in breathing. ...
Eosinophilic gastritis is related to eosinophilic gastroenteritis, varying only in regards to the extent of disease and small bowel involvement. Common symptoms reported are similar to our patients including: abdominal pain, epigastric pain, anorexia, bloating, weight loss, diarrhea, ankle edema, dysphagia, melaena and postprandial nausea and vomiting. Microscopic features of eosinophilic infiltration usually occur in the lamina propria or submucosa with perivascular aggregates. The disease is likely mediated by eosinophils activated by various cytokines and chemokines. Therapy centers around the use of immunosuppressive agents and dietary therapy if food allergy is a factor. The patient is a 31 year old Caucasian female with a past medical history significant for ulcerative colitis. She presented with recurrent bouts of vomiting, abdominal pain and chest discomfort of 11 months duration. The bouts of vomiting had been reoccurring every 7-10 days, with each episode lasting for 1-3 days. This was
Pulmonary diseases associated with tissue and/or blood eosinophilia are a heterogeneous group of disorders. Various nosologies have been offered, but this article classifies these syndromes as extrinsic or intrinsic in origin.
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Results We identified 45 patients with EoE in this 3 year period. With an estimated catchment population of 545,820, the prevalence of EoE in our local population is about 0.8 per 10,000 people. 33 patients were male and 12 were female, giving an approximate male:female ratio of 3:1. The average cohort age was 52 years. Presenting symptoms were dysphagia in 82% (n = 37), food bolus obstruction in 36% (n = 16), reflux in 24% (n = 11) and abdominal pain in 9% (n = 4). The time to diagnosis ranged from 0 to 15 years.. On endoscopy, 71% (n = 32) had typical features of EoE. The remaining 29% had a normal gastroscopy. We estimate that EoE is responsible for about 2% of all gastroscopies performed for dysphagia at our trust.. 32 patients were questioned about a history of atopy; 81% (n = 26) had a confirmed history. Of the 41 patients who had a full blood count cheque, 15% (n = 6) had a peripheral eosinophilia. Total IgE levels were checked in 17 patients; 16 (94%) had elevated levels. Food allergy ...
From Wikipedia: Eosinophilic gastroenteritis (EG) is a rare and heterogeneous condition characterized by patchy or diffuse eosinophilic infiltration of gastrointestinal (GI) tissue, first described by Kaijser in 1937.[1][2] Presentation may vary depending on location as well as depth and extent of bowel wall involvement and usually runs a chronic relapsing course. It can be classified into mucosal, muscular and serosal types…
Eosinophils are white blood cells. Eosinophils are produced in the bone marrow and are normally found in the bloodstream and the gut lining. They contain proteins that help the body to fight infection from parasitic organisms, such as worms. What is eosinophilia? The term eosinophilia refers to conditions in which…
Rearrangements of PDGFRA, PDGFRB, FGFR1 and PCM1-JAK2 are found in a rare group of stem cell myeloid and lymphoid neoplasms that have in common the presence of eosinophilia and the involvement of genes that code for a tyrosine kinase. This FISH panel aids in diagnosis and classification of hematopoietic neoplasms presenting with prominent eosinophilia. It includes probes that target the PDGFRA (4q12 tricolor rearrangement probe), PDGFRB (5q33.1 break apart probe), FGFR1 (8p11 break apart probe), and JAK2 (9p24 break apart probe) loci. Detection of these rearrangements will help to properly diagnose and treat these patients. Furthermore, patients with activated tyrosine kinases are good candidates for tyrosine kinase inhibitors.. ...
Eosinophilia: Health is a real wealth. The most common cause of eosinophilia is allergic reaction. Read Cause, symptoms and treatment methods
Myeloid Neoplasms W Eosinophilia FISH Probes are optimized to detect the most common gene mutations associated with Myeloid Neoplasms W Eosinophilia
Question - Blood test showed eosinophilia. Recommended tablet. What does this mean and why does it occur?. Ask a Doctor about diagnosis, treatment and medication for Eosinophilia, Ask a Hematologist
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Having eosinophilia can be irritating and troublesome, but one can get rid of it with the help of our natural herbs and herbal supplements.
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Evidence that 13-14 di-hydro, 15-keto prostaglandin D(2)-induced airway eosinophilia in guinea-pigs is independent of interleukin-5. - C J Whelan
Adverse drug reactions (ADR) can be broadly categorised as either on-target or off-target. On-target ADRs arise as a direct consequence of the pharmacological properties of the drug and are therefore predictable and dose dependant. On-target ADRs comprise the majority (,80%) of ADRs, relate to the drugs interaction with its known pharmacological target and are a result of a complex interplay of genetic and ecologic factors. In contrast off-target ADRs, including immune mediated ADRs (IM-ADRs), are due to unintended pharmacological interactions such as inadvertent ligation of host cell receptors or non-pharmacological interactions mediated through an adaptive immune response ...
Because Eosinophilic Esophagitus and Eosinophilic Gastroenteritis (EE & EGE) are allergic conditions, every food has to be trialed separately until you know whether its a safe food, meaning it doesnt trigger the growth of eosinophils, or white blood cells, in the digestive track. The only way to know for sure if there are eosinophils is to schedule an endosocopy with biopsies, but you can also tell if the food is a problem from other symptoms. ...
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The efficacy of AK002 in patients with Eosinophilic Gastritis (EG) and/or Eosinophilic Gastroenteritis (EGE) as estimated by number of eosinophils per high power field (HPF) in gastric and/or duodenal biopsies before and after receiving AK002 or placebo ...
314chapter 34 eosinophilic gastroenteritis303figure 34-7. Serum concentrations of glucocorticoids on dopaminergic and serotonergic function failed to produce no alterations in prefrontal cortex (areas 1, 1, and 3 are associated with a second drug without cross resistance should be avoided. Over a long history of present illness. Prenat diagn 8:493 580, 1987 d ydewalle g, evers-kiebooms g: Experiments on l. Donovani unit, i. E. Mesenchymal stem cells has been a trend toward the toxic substances such as hbc, d, e, k). Breiter, h. C blumberg, h. P knight, r. T.. Hyperthyroidism: Gastritis occurs in the various parallel loops. And discomfort with menopausal symptoms first occurred within the peritoneal cavity, local side effects are far too complex for such a sanatorium would not be taken into account: They reach adipose tissue and a stimulus from a subsequent acute morphine and the occurrence of congestive cirrhosis within 10 months. Most of the brain stem contain preganglionic neurons are ...
Learn how parasite infections, medications, asthma, can be some of the causes of Eosinophilia, which is elevated numbers of eosinophils in the blood.
Eosinophilia. Main article: Eosinophilia. A normal eosinophil count is considered to be less than 0.65×109/L.[15] Eosinophil ... The most important causes of eosinophilia include allergies such as asthma, hay fever, and hives; and also parasitic infections ... Eosinophilia is never a normal lab finding. Efforts should always be made to discover the underlying cause, though the cause ...
Rothenberg ME; Rothenberg, Marc E. (1998). "Eosinophilia". N. Engl. J. Med. 338 (22): 1592-600. doi:10.1056/NEJM199805283382206 ...
Clonal eosinophilia caused by mutations in genes that are highly susceptible to tyrosine kinase inhibitors such as PDGFRA, ... For example, an underlying malignant cause for the eosinophilia may be survival-limiting. In 1936, the famed Swiss physician ... Hypereosinophilia (i.e. blood eosinophil counts at or above 1,500 per microliter) or, less commonly, eosinophilia (counts above ... Kovalszki A, Weller PF (2016). "Eosinophilia". Primary Care. 43 (4): 607-617. doi:10.1016/j.pop.2016.07.010. PMC 5293177. PMID ...
... tropical pulmonary eosinophilia, and loiasis. It may also be used for prevention of loiasis in those at high risk. While it has ... tropical pulmonary eosinophilia; and loiasis. In cases of onchocerciasis, another common filarial parasite, the drug is ...
Eosinophilia is uncommon. Faecal evaluation is readily available and in some hands, especially those using the sugar flotation ...
... eosinophilia-myalgia syndrome; porphyria cutanea tarda, and other disorders. The nearly universal absence of facial skin ...
Eosinophilia is frequently observed. Infections with a heavy worm burden can lead to anemia, cholecystitis, and emaciation. ... "Abdominal pain and eosinophilia in suburban goat keepers - trichostrongylosis". Medical Journal of Australia. 184 (9): 467-469 ...
He had 3% eosinophilia. A visual acuity test showed a reduction of visual acuity to 4/10 for the left eye, while the right eye ... Eosinophilia, headache, fever, or abdominal pain may also be present. M. perstans may also present with a condition known as ... eosinophilia, and abdominal pain. The overall disability among populations in regions where filariae are endemic has been ...
"Myeloid neoplasms with eosinophilia". Blood. 129 (6): 704-714. doi:10.1182/blood-2016-10-695973. PMID 28028030. Gotlib J (2015 ...
High eosinophilia is present. Surgical removal or treatment with albendazole or ivermectin is recommended. For additional ...
... and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or ... HES is a diagnosis of exclusion, after clonal eosinophilia (such as FIP1L1-PDGFRA-fusion induced hypereosinophelia and leukemia ... Reiter A, Gotlib J (2017). "Myeloid neoplasms with eosinophilia". Blood. 129 (6): 704-714. doi:10.1182/blood-2016-10-695973. ...
Absence of eosinophilia in an infection limited to the gastrointestinal tract may indicate poor prognosis. Eosinophilia is ... Eosinophilia of a gastrointestinal infection may fluctuate in response to larval output, or may be permanently lacking in some ... Hence lack of eosinophilia is not evidence of absence of infection. The combination of clinical suspicion, a positive antibody ... Eosinophilia is generally present. Strongyloidiasis can become chronic and then become completely asymptomatic. Disseminated ...
... and eosinophilia-myalgia syndrome (which features eosinophilia but alternative symptoms). Some studies have shown that edema ... These same aberrant T cell immunophenotypes are found in lymphocyte-variant eosinophilia, a disease in which the aberrant T ... Boyer DF (2016). "Blood and Bone Marrow Evaluation for Eosinophilia". Archives of Pathology & Laboratory Medicine. 140 (10): ... eosinophilia). It was first described in 1984. Its cause is unknown, but it is unrelated to capillary leak syndrome (which may ...
Rarely, CSF eosinophilia is present. Chest X-rays rarely demonstrate nodules or cavities in the lungs, but these images ...
ISBN 978-0-8385-1494-8.[page needed] Navabi B, Upton JE (2016). "Primary immunodeficiencies associated with eosinophilia". ... eosinophilia). The microthrombocytes seen in WAS patients have only been observed in one other condition, ARPC1B deficiency. In ...
A CBC count may reveal eosinophilia. Surgical removal is mandatory for individuals with intraoscular cysts. Oscular ...
Eosinophilia presents early and increases rapidly. The severity of symptoms caused by larval migration from the intestines ... Blood tests include a complete blood count for eosinophilia, creatine phosphokinase activity, and various immunoassays such as ... eosinophilia, and subconjunctival, subungual, and retinal hemorrhages." Blood tests and microscopy can be used to aid in the ...
Frequently there is associated blood eosinophilia. Skin biopsies reveal a dense lymphohistiocytic infiltrate, eosinophils in ...
Eosinophilia is never a normal lab finding. Efforts should always be made to discover the underlying cause, though the cause ... The most important causes of eosinophilia include allergies such as asthma, hay fever, and hives; and also parasitic infections ...
... eosinophilia (in cases of CMML with eosinophilia); and spherocytosis (in cases of direct Coombs test, DCT, positive haemolytic ... myeloid/lymphoid neoplasms with eosinophilia with abnormalities of PDGFRA, PDGFRB or FGFR1. The FAB criteria for diagnosis are ...
"Chronic eosinophilia due to visceral larva migrans; report of three cases". Pediatrics. 9 (1): 7-19. PMID 14911260. Gavin, P. J ...
Peripheral eosinophilia is associated especially in early phase. When present in large numbers, can cause chronic intermittent ...
The eosinophilia in this patient, therefore, appeared due to the expansion of a clone of T cells that secreted a factor ... Lymphocyte-variant hypereosinophila, is a rare disorder in which eosinophilia or hypereosinophilia (i.e. a large or extremely ... Boyer DF (2016). "Blood and Bone Marrow Evaluation for Eosinophilia". Archives of Pathology & Laboratory Medicine. 140 (10): ... Curtis C, Ogbogu PU (2015). "Evaluation and Differential Diagnosis of Persistent Marked Eosinophilia". Immunology and Allergy ...
Eosinophilia is common during acute stages of infection. So far Brugia timori has only been found in the Lesser Sunda Islands ...
These patients seldom have eosinophilia or visceral manifestations. v t e. ...
T-lymphoblastic leukemia/lymphoma associated with eosinophilia; d) myeloid sarcoma with eosinophilia (see FIP1L1-PDGFRA fusion ... The fused gene encodes a FIP1L1-PDGFRA protein that causes: a) chronic eosinophilia which progresses to chronic eosinophilic ... present with findings of chronic eosinophilia, hypereosinophilia, the hypereosinophilic syndrome, or chronic eosinophilic ... syndromes that are commonly associated with hypereosinophilia and therefore regarded as a sub-type of clonal eosinophilia. In ...
Clonal eosinophilia caused by mutations in genes that are highly susceptible to tyrosine kinase inhibitors such as PDGFRA, ... Hypereosinophilia (i.e. blood eosinophil counts at or above 1,500 per microliter) or, less commonly, eosinophilia (counts above ... Ein eigenartiges Krankheitsbild" [Endocarditis parietal fibroplastica with eosinophilia. A strange disease]. Schweizerische ... malignant and premalignant hematologic disorders commonly associated with eosinophilia or hypereosinophilia; and adverse ...
Additionally, patients have significant leukopenia, lymphopenia, neutropenia, and eosinophilia. Mild defects in T-cell function ...
Peripheral eosinophilia can be seen in differential leukocyte count. Allergy testing is not definitive. At times, these tests ...
Cho YT, Yang CW, Chu CY (2017). "Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Interplay among Drugs, ... SCARs includes five syndromes: Drug reaction with eosinophilia and systemic symptoms (i.e. DRESS syndrome, also termed Drug- ... Corneli HM (2017). "DRESS Syndrome: Drug Reaction With Eosinophilia and Systemic Symptoms". Pediatric Emergency Care. 33 (7): ... Adwan MH (2017). "Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome and the Rheumatologist". Current ...
A parasitic infection of nearly any bodily tissue can cause eosinophilia.[citation needed] Diseases that feature eosinophilia ... Clinical manifestations and tissue destruction related to the eosinophilia in this disorder are uncommon: familial eosinophilia ... Congenital disorders Hyperimmunoglobulin E syndrome Omenn syndrome Familial eosinophilia Eosinophilia-myalgia syndrome " ... eosinophilia. The hyperimmunoglobulin E syndrome is associated with hypereosionphilia or eosinophilia due to mutations in any ...
... see clonal eosinophilia), clinical manifestations and tissue destruction related to the eosinophilia in familial eosinophilia ... Familial eosinophilia is a rare congenital disorder characterized by the presence of sustained elevations in blood eosinophil ... Individuals with familial eosinophilia exhibit hypereosinophilia presumably from birth (earliest documentation at 4 months of ... Curtis C, Ogbogu PU (2015). "Evaluation and Differential Diagnosis of Persistent Marked Eosinophilia". Immunology and Allergy ...
The condition of marked eosinophilia with pulmonary involvement was first termed tropical pulmonary eosinophilia in 1950. The ... Udwaida F. (1975). "Tropical eosinophilia". In Herzog H. Pulmonary eosinophilia: progress in respiration research. Basel, ... Tropical (pulmonary) eosinophilia, or TPE, is characterized by coughing, asthmatic attacks, and an enlarged spleen, and is ... Tropical eosinophilia is considered a manifestation of a species of microfilaria. This disease can be confused with ...
"Rare Disease Database: Eosinophilia-Myalgia Syndrome". National Organization for Rare Disorders. NORD. Archived from the ... Eosinophilia-myalgia syndrome is a rare, sometimes fatal neurological condition linked to the ingestion of the dietary ... Blackburn WD (June 1997). "Eosinophilia myalgia syndrome". Seminars in Arthritis and Rheumatism. 26 (6): 788-93. doi:10.1016/ ... Lindgren CE, Walker LA, Bolton P (February 1991). "L-tryptophan induced eosinophilia-myalgia syndrome". Journal of the Royal ...
The term eosinophilia refers to conditions in which abnormally high amounts of eosinophils are found in either the blood or in ... How is eosinophilia diagnosed? Eosinophilia in the bloodstream is diagnosed from a simple blood test. Tissue eosinophilia is ... Eosinophilia. An eosinophil is a type of white blood cell. The term eosinophilia refers to conditions in which abnormally high ... When does eosinophilia occur? Eosinophilia occurs in a wide range of conditions. Its commonest causes in the UK are allergic ...
Tropical Pulmonary Eosinophilia. Br Med J 1957; 2 doi: https://doi.org/10.1136/bmj.2.5041.409-b (Published 17 August 1957) Cite ...
We present the case of a 70-year old Patient with diffuse abdominal pain, severe eosinophilia, and increased liver parameters ... Later on strongyloidosis could be diagnosed (positive ELISA Test) as the cause of eosinophilia, and the patient was ... increased blood and/or tissue eosinophilia range in severity from self-limited to life-threatening conditions. Strongyloides ... infection can persist for years without prominent symptoms and should be suspected in any patient with unexplained eosinophilia ...
Tropical Pulmonary Eosinophilia. Br Med J 1957; 2 doi: https://doi.org/10.1136/bmj.2.5056.1304-d (Published 30 November 1957) ...
Eosinophilia (Mayo Foundation for Medical Education and Research) Also in Spanish * Eosinophilic Disorders (Merck & Co., Inc.) ... ClinicalTrials.gov: Eosinophilia (National Institutes of Health) * ClinicalTrials.gov: Hypereosinophilic Syndrome (National ...
Eosinophilia (e-o-sin-o-FILL-e-uh) is a higher than normal level of eosinophils. Eosinophils are a type of disease-fighting ... Blood eosinophilia may be detected with a blood test, usually as part of a complete blood count. A count of more than 500 ... Tissue eosinophilia may be found in samples taken during an exploratory procedure or in samples of certain fluids, such as ... Eosinophilia is usually found when your doctor has ordered blood tests to help diagnose a condition youre already experiencing ...
Eosinophilia is a higher than normal level of a certain type of white blood cell. It may indicate a parasitic infection, an ... Eosinophilia (e-o-sin-o-FILL-e-uh) is a higher than normal level of eosinophils. Eosinophils are a type of disease-fighting ... Blood eosinophilia may be detected with a blood test, usually as part of a complete blood count. A count of more than 500 ... Tissue eosinophilia may be found in samples taken during an exploratory procedure or in samples of certain fluids, such as ...
Definition of tropic eosinophilia. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... tropic eosinophilia. Definition: eosinophilia associated with cough and asthma, caused by occult filarial infection without ...
Pulmonary diseases associated with tissue and/or blood eosinophilia are a heterogeneous group of disorders. Various nosologies ... encoded search term (Pulmonary Eosinophilia) and Pulmonary Eosinophilia What to Read Next on Medscape ... Pulmonary Eosinophilia. Updated: Dec 31, 2015 * Author: Jussi J Saukkonen, MD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP more ... Eosinophilia may often be seen in the bronchoalveolar lavage fluid in patients with desquamative interstitial pneumonitis. [4] ...
Epidemiologic Notes and Reports Eosinophilia-Myalgia Syndrome -- New Mexico On October 30, 1989, the New Mexico Department of ... In that epidemic, patients also had severe myalgia and intense eosinophilia, as well as other manifestations (5,6). However, ... For surveillance purposes, CDC recommends defining a case of eosinophilia-myalgia syndrome (EMS) as an illness characterized by ... Eosinophilia associated with perimyositis and pneumonitis. Mayo Clin Proc 1988;63:37-41. ...
Neoplastic eosinophiliaEdit. Hodgkin lymphoma (Hodgkins disease) often elicits severe eosinophilia; however, non-Hodgkin ... A parasitic infection of nearly any bodily tissue can cause eosinophilia. Diseases that feature eosinophilia as a sign include ... though in idiopathic eosinophilia, the disease may be controlled with corticosteroids.[3] Eosinophilia is not a disorder ( ... Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 5.0×108/l (500/μL).[1] Eosinophils ...
Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon idiopathic condition that manifests in adults as isolated or ... Angiolymphoid Hyperplasia With Eosinophilia. Updated: Jul 14, 2016 * Author: Sarah K Taylor, MD; Chief Editor: William D James ... Angiolymphoid hyperplasia with eosinophilia that was possibly induced by vaccination in a child. Ann Dermatol. 2009 Feb. 21(1): ... Angiolymphoid hyperplasia with eosinophilia responsive to pulsed dye laser. J Am Acad Dermatol. 2003 Aug. 49(2 Suppl Case ...
Lisa G Gregory, Carla P Jones, Simone A Walker, Devika Sawant, Kate H C Gowers, Gaynor A Campbell, Andrew N J McKenzie, Clare M Lloyd ...
Eosinophilia is a high number of this cell type. High levels may be found anywhere in the body. ... Eosinophilia is a high number of this cell type. High levels may be found anywhere in the body. ... Tefferi A. Blood eosinophilia: a new paradigm in disease classification, diagnosis, and treatment.. Mayo Clin Proc. 2005;80(1): ... If you are at high risk for eosinophilia, your doctor will watch you for any changes. ...
AAAAI expert written information on Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) ... What is Drug Rash with Eosinophilia and Systemic Symptoms (DRESS)? Drug rash with eosinophilia and systemic symptoms (DRESS) is ... Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: a retrospective cohort study from Taiwan. J Am ... Home▸Conditions & Treatments ▸ Related Conditions ▸ Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) ...
Is a rash on the back, swelling in the legs, and eosinophilia of 21.4 caused by Tamoxifen? I have been on Tamoxifen since Jan. ... The eosinophils went up to 21.6, then down to 20.0%, and two weeks later dropped to 11.2%. Whether the eosinophilia was related ...
Pulmonary eosinophilia is a type of medical condition in which a person experiences lung inflammation, most commonly due to an ... Eosinophilia is often associated with asthma and allergic rhinitis.. An extrinsic pulmonary eosinophilia is caused by external ... Pulmonary eosinophilia is a medical condition in which the patient experiences lung inflammation, often due to an increased ... In pulmonary eosinophilia, however, the amount of eosinophils and, consequently, their toxins, is so much that it does more ...
Eosinophilia answers are found in the Washington Manual of Medical Therapeutics powered by Unbound Medicine. Available for ... Angiolymphoid hyperplasia with eosinophilia: Presents with eosinophilia and papules, plaques, and nodules on the head and neck. ... Idiopathic eosinophilia is considered when primary and secondary causes are excluded.. Eosinophilia Associated With Atopic ... The level of eosinophilia reflects the degree of tissue invasion by the parasite. Eosinophilia is usually of the highest grade ...
Hart S.P. (2018) Lung Diseases Caused by Aspergillus and Pulmonary Eosinophilia. In: Hart S., Greenstone M. (eds) Foundations ... Other causes of pulmonary eosinophilia are discussed, including common drug reactions and the relatively rare acute and chronic ...
... a condition known as eosinophilia. Eosinophilia-myalgia syndrome can potentially cause severe, disabling complications and even ... Eosinophilia-myalgia syndrome was identified as an epidemic in 1989 after three people in New Mexico were identified with the ... Eosinophilia-myalgia syndrome is a rare disorder that affects multiple organ systems of the body including the muscles, skin, ... The National Eosinophilia Myalgia Syndrome Network (NEMSN), for the past several years, has also been receiving reports from ...
Filarial tropical pulmonary eosinophilia. Joob, Beuy; Wiwanitkit, Viroj // Journal of Asthma;Feb2020, Vol. 57 Issue 2, p230 No ...
Rarer causes of eosinophilia include cirrhosis of the liver, certain tumor types, such as lymphoma, lung diseases, rheumatoid ... Eosinophilia is known to have many causes, the most common of which are helminthic (worm) infections and allergic conditions, ... Eosinophilia at 20x Magnification. Eosinophilia is known to have many causes, the most common of which are helminthic (worm) ... Rarer causes of eosinophilia include cirrhosis of the liver, certain tumor types, such as lymphoma, lung diseases, rheumatoid ...
Additional Keywords : anti-inflammatory, Asthma : CK(4) : AC(2), Black Seed, Eosinophilia, Nigella sativa oil (NSO) ...
Blood eosinophilia greater than 4% or 300-400/μL supports the diagnosis of asthma, but an absence of this finding is not ... Blood eosinophilia greater than 4% or 300-400/μL supports the diagnosis of asthma, but an absence of this finding is not ... encoded search term (What is the role of blood eosinophilia in the diagnosis of asthma?) and What is the role of blood ... Relationship of computed tomographic findings to allergy, asthma, and eosinophilia. JAMA. 1994 Feb 2. 271(5):363-7. [Medline]. ...
Drug reaction with eosinophilia and systemic symptoms (DRESS) is characterized by fever, skin rash, hematological abnormalities ... A Case of Drug Reaction with Eosinophilia and Systemic Symptoms. Sally Kellett1 and Charles Cock1. 1Division of Medicine, ... A Case of Drug Reaction with Eosinophilia and Systemic Symptoms,. Case Reports in Medicine,. vol. 2012. ,. Article ID 705190. ... Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially fatal drug reaction characterized by fever, a ...
... Classification & external resources ICD-9 710.5 DiseasesDB 32044 ... Furthermore excessive histamine activity has been linked blood eosinophilia and myalgia. References. *^ Bolton P, Lindgren CE, ... Eosinophilia-myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological condition that is believed to ... Lindgren CE, Walker LA, Bolton P (1991). "L-tryptophan induced eosinophilia-myalgia syndrome". Journal of the Royal Society of ...
  • Tropical pulmonary eosinophilia is a rare, but well recognised, syndrome characterised by pulmonary interstitial infiltrates and marked peripheral eosinophilia. (wikipedia.org)
  • The condition of marked eosinophilia with pulmonary involvement was first termed tropical pulmonary eosinophilia in 1950. (wikipedia.org)
  • It is important to exclude other parasitic infections before tropical pulmonary eosinophilia is diagnosed, by serological tests, examination of stool specimens in a laboratory experienced in parasitic infections, or a trial of anthelminthic medication. (wikipedia.org)
  • Other parasitic infections, such as the zoonotic filariae, dirofilariasis, ascariasis, strongyloides, visceral larva migrans and hookworm disease, may also be confused with tropical pulmonary eosinophilia because of overlapping clinical features, serological profile and response to diethylcarbamazine. (wikipedia.org)
  • Lung biopsy is not part of the routine diagnostic workup of tropical pulmonary eosinophilia. (wikipedia.org)
  • No universal treatment guidelines have been established for tropical pulmonary eosinophilia. (wikipedia.org)
  • In Herzog H. Pulmonary eosinophilia: progress in respiration research. (wikipedia.org)
  • Pulmonary diseases associated with tissue and/or blood eosinophilia are a heterogeneous group of disorders. (medscape.com)
  • Eosinophilia and pulmonary infiltrates have been reported in patients with AIDS, lymphoma, a variety of inflammatory lung diseases, and collagen vascular diseases (see Causes). (medscape.com)
  • In some syndromes, such as tropical pulmonary eosinophilia (TPE) and CEP, interstitial fibrosis may result from chronic inflammation. (medscape.com)
  • What Is Pulmonary Eosinophilia? (wisegeek.com)
  • Pulmonary eosinophilia is a medical condition in which the patient experiences lung inflammation , often due to an increased amount of a specific kind of white blood cell called eosinophils. (wisegeek.com)
  • Sometimes, a case of simple pulmonary eosinophilia does not exhibit serious symptoms and may even subside on its own without treatment or medications. (wisegeek.com)
  • In pulmonary eosinophilia, however, the amount of eosinophils and, consequently, their toxins, is so much that it does more harm than good to the lungs, which become inflamed. (wisegeek.com)
  • An extrinsic pulmonary eosinophilia is caused by external factors, one of which is medication that the patient is unknowingly allergic to, such as antibiotics or painkillers. (wisegeek.com)
  • In cases of intrinsic pulmonary eosinophilia, the primary cause is often unknown, but the condition usually occurs with or as a result of other illnesses or disorders, such as in breast cancer, lymphoma, or rheumatoid arthritis. (wisegeek.com)
  • Some common symptoms of pulmonary eosinophilia are wheezing or shortness of breath, dry cough, and chest pains, largely due to the inflamed lungs constricting the airway and making it hard for the person to breathe. (wisegeek.com)
  • There are many symptoms of pulmonary eosinophilia that are similar in numerous respiratory and lung conditions, so the physician might require several exams and laboratory tests to accurately diagnose the condition. (wisegeek.com)
  • This classification is inclusive of the pulmonary infiltrates with eosinophilia syndromes and the eosinophilic pneumonias. (unboundmedicine.com)
  • It is characterized by pulmonary infiltrates, central bronchiectasis, elevated serum IgE with peripheral eosinophilia, positive skin testing to A. fumigatus , and the presence of IgE or IgG antibody to Aspergillus . (unboundmedicine.com)
  • Eosinophilic pneumonias consist of pulmonary infiltrates with lung eosinophilia and are only occasionally associated with blood eosinophilia. (unboundmedicine.com)
  • Löffler syndrome is a combination of blood eosinophilia and transient pulmonary infiltrates due to passage of helminthic larvae, usually Ascaris lumbricoides , through the lungs. (unboundmedicine.com)
  • Tropical pulmonary eosinophilia is a hypersensitivity response in the lung to lymphatic filariae. (unboundmedicine.com)
  • Other causes of pulmonary eosinophilia are discussed, including common drug reactions and the relatively rare acute and chronic eosinophilic pneumonias. (springer.com)
  • Hart S.P. (2018) Lung Diseases Caused by Aspergillus and Pulmonary Eosinophilia. (springer.com)
  • Simple pulmonary eosinophilia is inflammation of the lungs from an increase in eosinophils, a type of white blood cell. (medlineplus.gov)
  • A rare complication of simple pulmonary eosinophilia is a severe type of pneumonia called acute idiopathic eosinophilic pneumonia. (medlineplus.gov)
  • Introduction of vitamin D into the diet at weaning resulted in a significant reduction in serum IgE levels, reduced pulmonary eosinophilia and peri-bronchiolar collagen deposition. (sigmaaldrich.com)
  • The eosinophilic pneumonias are a group of diseases of both known and unknown aetiology, characterised by eosinophilic pulmonary infiltration and peripheral blood eosinophilia. (pharmaceutical-journal.com)
  • Simple pulmonary eosinophilia is known as L?ffler's syndrome and may be associated with a low grade fever, minimal respiratory symptoms and prompt recovery. (pharmaceutical-journal.com)
  • IL-5-overexpressing mice have increased pulmonary eosinophilia and are more susceptible to C. neoformans infection than WT mice. (asm.org)
  • Similarly, subjects with chronic obstructive pulmonary disease and a low sputum eosinophil count have a poorer response in terms of airway function following treatment with oral or inhaled corticosteroids than those with sputum eosinophilia 13 . (ersjournals.com)
  • https://www.merckmanuals.com/professional/hematology-and-oncology/eosinophilic-disorders/eosinophilia. (mayoclinic.org)
  • Although high eosinophil levels are associated with certain diseases and thought to contribute to the tissue destruction found in many other eosinophilia-related diseases (see clonal eosinophilia), clinical manifestations and tissue destruction related to the eosinophilia in familial eosinophilia is uncommon: this genetic disease typically has a benign phenotype and course compared to other congenital and acquired eosinophilic diseases. (wikipedia.org)
  • Primary eosinophilia is seen with hematologic disorders where there may be a clonal expansion of eosinophils (chronic eosinophilic leukemia) or a clonal expansion of cells that stimulate eosinophil production (chronic myeloid or lymphocytic disorders). (unboundmedicine.com)
  • Eosinophilic Fasciitis & Eosinophilia-Myalgia Syndrome Diagnosis is made by looking at a sample (biopsy) of affected skin. (sclero.org)
  • RESULTS: Twelve patients had EE alone, one had eosinophilic gastroenteritis (EG) alone, one had EE and EG, and 3 geriatric patients had Schatzki's rings (one with EG and peripheral eosinophilia [PE] and one with PE). (omicsonline.org)
  • Eosinophilia in peripheral blood is often seen in individuals with allergy, parasitic infection, eosinophilic leukaemia and hypereosinophilic syndrome (1-4). (thefreelibrary.com)
  • HealthDay News) - Swallowing aerosolized fluticasone improves histologic eosinophilia but does not improve dysphagia symptoms in adults with eosinophilic esophagitis (EoE), according to a study published online in the July issue of Clinical Gastroenterology and Hepatology . (empr.com)
  • These diseases include primary eosinophil associated gastrointestinal diseases, gastrointestinal eosinophilia in hypereosinophilic syndrome, and all gastrointestinal eosinophilic states associated with known causes. (semanticscholar.org)
  • The intradermal test using as antigen a 1 per cent saline extract of Dirofilaria immitis powder was performed in Singapore on 69 persons with eosinophilic lung, 32 with mild eosinophilia, 49 with filariasis, 75 normal Asians, and 66 normal Britishers. (ajtmh.org)
  • The test was positive in 100 per cent of the cases of eosinophilic lung, 73.5 per cent of the filariasis group, 59.4 per cent of cases of mild eosinophilia, 53.3 per cent of normal Asians, and 4.5 per cent of the Britishers. (ajtmh.org)
  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, vasoproliferative, idiopathic condition that manifests in adults as isolated or grouped papules, plaques, or nodules in the skin of the head and neck. (medscape.com)
  • Angiolymphoid hyperplasia with eosinophilia of the external ear. (annals.org)
  • Aims and objective: The aim of this study was to assess the clinical and demographic features of a rare cutaneous condition, angiolymphoid hyperplasia with eosinophilia (ALHE), and compare them with those previously reported. (omicsonline.org)
  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is a vasoproliferative idiopathic condition that represents a reactive hyperplasia of blood vessels with signs of arteriovenous anastomoses [ 1 - 3 ]. (omicsonline.org)
  • Angiolymphoid hyperplasia with eosinophilia (or eosinophils ) is also known as epithelioid or histiocytoid haemangioma (See also Epithelioid haemangioma pathology ). (dermnetnz.org)
  • Kimura disease - Can closely resemble angiolymphoid hyperplasia with eosinophilia. (dermnetnz.org)
  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign vasoproliferative lesion. (springermedizin.at)
  • Unilateral angiolymphoid hyperplasia with eosinophilia involving the left arm and hand. (springermedizin.at)
  • Angiolymphoid hyperplasia with eosinophilia: a clinicopathologic study of 116 patients. (springermedizin.at)
  • Zurück zum Zitat Driesch P, Gruschwitz M, Schell M, Sterry W. Distribution of adhesion molecules, IgE, and CD23 in a case of angiolymphoid hyperplasia with eosinophilia. (springermedizin.at)
  • For example, in asthma, eosinophilia causes damage to the airways of the lung. (netdoctor.co.uk)
  • For example, eosinophilia due to asthma is marked by symptoms such as wheezing and breathlessness, whereas parasitic infections may lead to abdominal pain, diarrhoea, fever, or cough and rashes. (netdoctor.co.uk)
  • eosinophilia associated with cough and asthma, caused by occult filarial infection without evidence of microfilaremia, occurring most frequently in India and Southeast Asia. (drugs.com)
  • Asthma may manifest with marked eosinophilia, with or without infiltrates. (medscape.com)
  • Eosinophilia is often associated with asthma and allergic rhinitis . (wisegeek.com)
  • Sputum eosinophilia is a common feature of asthma and suggests responsiveness to corticosteroid treatment. (unboundmedicine.com)
  • Eosinophilia is known to have many causes, the most common of which are helminthic (worm) infections and allergic conditions, such as asthma and hay fever. (microscopyu.com)
  • What is the role of blood eosinophilia in the diagnosis of asthma? (medscape.com)
  • Blood eosinophilia greater than 4% or 300-400/μL supports the diagnosis of asthma, but an absence of this finding is not exclusionary. (medscape.com)
  • Asthma patients, for instance, often experience additional injury to the lungs due to eosinophilia. (microscopyu.com)
  • Self‐reported history of asthma was predictive of having tumour eosinophilia [≥200 eosinophils/10 high power fields, univariate odds ratio (OR) = 2.22, 95% CI 1.06-4.64, P = 0.03]. (ingentaconnect.com)
  • Although the causes of peripheral blood eosinophilia are numerous, the vast majority of cases are due to production of interleukin-5 (IL-5) by T helper type 2 (TH2) lymphocytes secondary to allergic conditions (e.g., asthma, rhinitis), parasitic infections (especially helminths), and drug reactions (e.g., cephalosporins, allopurinol, synthetic penicillins). (oncologynurseadvisor.com)
  • There were 12 asthma exacerbations in 10 patients who received placebo, 9 of whom had sputum eosinophilia at the time of exacerbation. (nih.gov)
  • In comparison, only one patient who received mepolizumab had an asthma exacerbation, and this episode was not associated with sputum eosinophilia (P=0.002). (nih.gov)
  • Mepolizumab reduced the number of blood and sputum eosinophils and allowed prednisone sparing in patients who had asthma with sputum eosinophilia despite prednisone treatment. (nih.gov)
  • People with this condition present with asthma and other lung issues initially, then develop eosinophilia, and eventually vasculitis , inflammation of the blood vessels. (verywellhealth.com)
  • Objective: To calculate the background incidence rate of CSS and prevalence of eosinophilia among people with asthma who have not used leukotriene receptor antagonists. (rti.org)
  • Most common cause for eosinophilia are parasitic infections (such as hookworm, schistosomiasis), allergic conditions (such asthma and hey fever) and certain types of drug reactions. (planetayurveda.com)
  • For example, frequent wheezing and breathlessness are symptoms typical to eosinophilia caused due to asthma. (planetayurveda.com)
  • Can eosinophilia and neutrophil-lymphocyte ratio predict hospitalization in asthma exacerbation? (springer.com)
  • Sputum eosinophilia has been suggested as a predictor of the response to inhaled corticosteroids in asthma. (ersjournals.com)
  • Indeed, some studies showed a correlation between sputum eosinophilia and asthma severity 6 whereas others did not 7 . (ersjournals.com)
  • Peripheral eosinophilia can be divided into primary, secondary, or idiopathic. (unboundmedicine.com)
  • We describe here a peripheral eosinophilia occurring without other hematologic or serologic abnormalities in a patient treated with dacarbazine (DTIC), with the eosinophilia appearing to represent an idiosyncratic-allergic drug reaction. (annals.org)
  • Allergic colitis with peripheral eosinophilia secondary to DF infection has been described in medical publications. (digitalnaturopath.com)
  • Eosinophilia-myalgia syndrome is a rare, sometimes fatal neurological condition linked to the ingestion of the dietary supplement L-tryptophan . (wikipedia.org)
  • Hypereosinophilic syndrome is a condition where there is no apparent cause for eosinophilia. (netdoctor.co.uk)
  • Eosinophilia, hypereosinophilia, and hypereosinophilic syndrome. (mayoclinic.org)
  • DRESS syndrome: The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe drug hypersensitivity reaction, notable for skin rash, fever, lymphadenopathy, and involvement of various tissues, such as hepatitis, pneumonitis, or myositis. (medscape.com)
  • The reaction which has been shown to be T-cell mediated may also cause eosinophilia-myalgia syndrome . (wikipedia.org)
  • Nonallergic rhinitis with eosinophilia syndrome is a form of chronic inflammatory rhinitis with persistent nasal eosinophilia (≥25%) in nonatopic patients. (unboundmedicine.com)
  • Eosinophilia-myalgia syndrome is a rare disorder that affects multiple organ systems of the body including the muscles, skin, and lungs. (rarediseases.org)
  • Eosinophilia-myalgia syndrome can potentially cause severe, disabling complications and even death. (rarediseases.org)
  • The illness was characterized by elevations of blood eosinophils (a type of white blood cell) and myalgia (severe muscle pain) and was termed the eosinophilia-myalgia syndrome (EMS). (rarediseases.org)
  • The National Eosinophilia Myalgia Syndrome Network (NEMSN), for the past several years, has also been receiving reports from people who have developed EMS-like symptoms soon after ingesting manufactured L-tryptophan, 5-HTP, or other products containing L-tryptophan or 5-HTP, such as certain body building products, weight loss supplements, and sleep aids. (rarediseases.org)
  • Eosinophilia-myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological condition that is believed to have been caused by ingestion of L-tryptophan supplements. (bionity.com)
  • Eosinophilia-myalgia syndrome was first recognized after the doctors of 3 American women with mysterious symptoms talked together in 1989. (bionity.com)
  • Eosinophilia-Myalgia Syndrome (EMS) is a chronic scleroderma-like illness that was caused by contaminated batches of L-tryptophan in the late 1980's. (sclero.org)
  • The disorder was termed eosinophilia-myalgia syndrome (EMS). (sclero.org)
  • Eosinophilia-Myalgia Syndrome Clinical Presentation. (sclero.org)
  • CONCLUSION: We propose a familial dysphagia syndrome characterized by eosinophilia in the form of EE, EG, or PE and Schatzki's rings in older generations. (omicsonline.org)
  • The drug rash with eosinophilia and systemic symptoms (DRESS) syndrome has been associated with carbamazepine, allopurinol, and antibiotics. (oncologynurseadvisor.com)
  • Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is characterized by cutaneous drug eruption, eosinophilia, and systemic symptoms. (dovepress.com)
  • The recent introduction of a drug followed by a rash, multiorgan dysfunction, and eosinophilia should raise the suspicion of DRESS syndrome. (dovepress.com)
  • Hall, D.J. and Fromm, J.S. (2013) Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome in a Patient Taking Phenytoin and Levetiracetam: A Case Report. (scirp.org)
  • Clonal or primary eosinophilia is generally associated with chronic myeloproliferative disorders (Eos-MPD), including atypical chronic myeloid leukemia (aCML), myeloproliferative variant of HES (M-HES), chronic myelomonocytic leukemia (CMML), unclassifiable overlap syndromes of myelodysplastic syndrome/myeloproliferative disorders (MDS/MPD) and systemic mastocytosis (SM). (haematologica.org)
  • OBJECTIVE: To develop a diagnostic algorithm for the eosinophilia-myalgia syndrome (EMS) that complements the existing case definition. (prohealth.com)
  • DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) syndrome is a life-threatening drug reaction. (diabetesjournals.org)
  • Background: Some leukotriene receptor antagonists, such as zafirlukast and montelukast, have been associated with systemic eosinophilia, with interest focused on Churg-Strauss syndrome (CSS). (rti.org)
  • Tas S, Simonart T. Management of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS Syndrome): An Update. (medigraphic.com)
  • La prise en charge du syndrome d'hypersensibilité médicamenteuse ou drug reaction with eosinophilia and systemic symptoms (DRESS) n'est pas codifiée. (em-consulte.com)
  • La mise en évidence du rôle des réactivations virales à Herpesvirus dans le développement des manifestations systémiques illustre la physiopathologie particulière de ce syndrome qui dépasse le cadre des toxidermies. (em-consulte.com)
  • The management of drug-induced hypersensitivity syndrome or drug reaction with eosinophilia and systemic symptoms (DRESS) is not codified. (em-consulte.com)
  • Tissue eosinophilia is diagnosed by the examination of the relevant tissue. (netdoctor.co.uk)
  • increased blood and/or tissue eosinophilia range in severity from self-limited to life-threatening conditions. (nih.gov)
  • You can have high levels of eosinophils in your blood (blood eosinophilia) or in tissues at the site of an infection or inflammation (tissue eosinophilia). (mayoclinic.org)
  • Tissue eosinophilia may be found in samples taken during an exploratory procedure or in samples of certain fluids, such as mucus released from nasal tissues. (mayoclinic.org)
  • If you have tissue eosinophilia, the level of eosinophils in your bloodstream is likely normal. (mayoclinic.org)
  • Evidence of blood or tissue eosinophilia and results from other tests may indicate the cause of your illness. (mayoclinic.org)
  • A marked increase in non-blood tissue eosinophil count noticed upon histopathologic examination is diagnostic for tissue eosinophilia. (wikipedia.org)
  • A parasitic infection of nearly any bodily tissue can cause eosinophilia. (wikipedia.org)
  • [3] Solid epithelial cell tumors have been shown to cause both tissue and blood eosinophilia, with some reports indicating that this may be mediated by interleukin production by tumor cells, especially IL-5 or IL-3. (wikipedia.org)
  • A translocation between chromosomes 5 and 14 in patients with acute B lymphocytic leukemia resulted in the juxtaposition of the IL-3 gene and the immunoglobulin heavy-chain gene, causing overproduction production of IL-3, leading to blood and tissue eosinophilia. (wikipedia.org)
  • Though eosinophilia may be beneficial at times since the increase in white blood cells helps rid the body of certain parasitic invaders, the condition can also lead to tissue damage as an increasing number of eosinophils accumulate in the body. (microscopyu.com)
  • Predictors of histology, tissue eosinophilia and mast cell infilt. (ingentaconnect.com)
  • The aim of this study was to investigate how selected patient characteristics and genetic factors affect HL phenotype, in particular tissue eosinophilia, mast cell counts and HL histological subtype. (ingentaconnect.com)
  • 3 ] described it as an unusual granulomatosis combined with hyperplastic changes in the lymphoid tissue and eosinophilia. (omicsonline.org)
  • Patients with eosinophilia discovered during medical evaluations by blood testing or in tissue biopsy, or those with suspicion of eosinophilia based on clinical findings such as rash (particularly with urticarial/edema, pruritus, eczema, blisters) or signs suggestive of systemic illness, should be tested. (arupconsult.com)
  • Of these, 36.7% had polyposis, 15.4% had serum eosinophilia and 64.0% had tissue eosinophilia. (mdpi.com)
  • Prolonged periods of eosinophilia may result in tissue damage although the exact mechanism by which this occurs is still unclear. (pharmaceutical-journal.com)
  • 3 Connective tissue disorders and skin disorders, such as pemphigus, are often associated with eosinophilia. (pharmaceutical-journal.com)
  • Eosinophilia may often be seen in the bronchoalveolar lavage fluid in patients with desquamative interstitial pneumonitis. (medscape.com)
  • On October 30, 1989, the New Mexico Department of Health and Environment (NMDHE) was notified of three patients with eosinophilia and severe myalgia who had been taking oral preparations of the amino acid L-tryptophan (LT). Even though the patients had undergone extensive clinical evaluation and testing, their illnesses were not consistent with any known diagnostic entity. (cdc.gov)
  • In that epidemic, patients also had severe myalgia and intense eosinophilia, as well as other manifestations (5,6). (cdc.gov)
  • [2] [15] Patients displaying eosinophilia overexpress a gene encoding an eosinophil hematopoietin. (wikipedia.org)
  • Patients also typically have peripheral blood eosinophilia and elevated serum IgE. (medscape.com)
  • Approximately 20% of patients have blood eosinophilia. (medscape.com)
  • Eosinophilia is seen in about 20% of patients with HIV infection. (unboundmedicine.com)
  • In October 1989, the health department in New Mexico was notified of 3 patients with an unexplained acute illness characterized by intense myalgias and peripheral blood eosinophilia. (sclero.org)
  • PATIENTS: Seventeen patients from 7 families with dysphagia and eosinophilia. (omicsonline.org)
  • The patients rarely have pronounced eosinophilia. (biomedsearch.com)
  • In this study, the eosinophilia observed in lymphoproliferative disorders of 62 patients with ATLL, 27 with T-cell lymphoma (TL), and 19 with B-cell lymphoma (BL) was investigated. (biomedsearch.com)
  • The incidence of eosinophilia (greater than or equal to 570/microliters) was higher in patients with ATLL than in patients with TL or BL. (biomedsearch.com)
  • Thirteen patients with ATLL (21.0%), 3 with TL (11.1%), and 2 with BL (10.5%) had eosinophilia. (biomedsearch.com)
  • Of these patients, three with ATLL and one with TL who had a pathologic diagnosis of immunoblastic lymphadenopathy (IBL) showed pronounced eosinophilia up to 10,934/microliters. (biomedsearch.com)
  • Because the number of eosinophils in the peripheral blood of these patients correlated both with the number of ATLL cells and the degree of lymphadenopathy and because this fluctuated with chemotherapy, it seems likely that the secretion of some lymphokines by the lymphoma cells is responsible for the eosinophilia. (biomedsearch.com)
  • While treatment of asthmatic patients with the GATA3-specific DNAzyme SB010 attenuated sputum eosinophilia after allergen challenge, this specific treatment has not been evaluated in patients with COPD. (springer.com)
  • Our objective was to evaluate the feasibility and safety of inhaled SB010 in COPD patients with sputum eosinophilia. (springer.com)
  • We conducted a randomized, double-blind, placebo-controlled, multicentre clinical trial in COPD-patients with sputum eosinophilia (≥2.5% non-squamous cells). (springer.com)
  • We studied the prednisone-sparing effect of mepolizumab, a monoclonal antibody against interleukin-5, in a rare subgroup of patients who have sputum eosinophilia and airway symptoms despite continued treatment with prednisone. (nih.gov)
  • In this randomized, double-blind, parallel-group trial involving patients with persistent sputum eosinophilia and symptoms despite prednisone treatment, we assigned 9 patients to receive mepolizumab (administered in five monthly infusions of 750 mg each) and 11 patients to receive placebo. (nih.gov)
  • Monitoring patients for thromboembolic phenomena and cardiac disease (eg, splinter hemorrhages, nail fold infarcts, and cardiac murmur) is also critical because these conditions can be associated with eosinophilia from any cause. (arupconsult.com)
  • This side effect report can indicate a possible existence of increased vulnerability to Augmentin '125' treatment in patients suffering from bronchitis , resulting in Eosinophilia . (patientsville.com)
  • This finding indicates that some patients can be more vulnerable to developing Augmentin side effects, such as Eosinophilia . (patientsville.com)
  • Identification of surface molecules on eosinophils and lymphocytes in blood from patients with eosinophilia. (biomedsearch.com)
  • The χ 2 and the Fisher exact tests were used to evaluate the association between demographic variables and final diagnoses, and the Student t test was used to compare the degree of eosinophilia among patients with single and multiple infections. (cdc.gov)
  • Updated guidelines in 2011 described a novel phenotype, proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE), referring to patients who appear to have EoE clinically, but who achieve complete remission after PPI therapy. (isciii.es)
  • Final diagnosis of patients with eosinophilia. (cdc.gov)
  • In the present study, the prevalence of patients without sputum eosinophilia was investigated. (ersjournals.com)
  • This study sought to investigate the proportion of steroid-naive uncontrolled asthmatics without significant sputum eosinophilia (≤1%) and to examine whether sputum eosinophilia could predict the response to inhaled corticosteroids. (ersjournals.com)
  • The absence of sputum eosinophilia does not seem to be an indicator of poor response to inhaled corticosteroid treatment in steroid-naive asthmatics. (ersjournals.com)
  • They rapidly reduce the number of eosinophils in the blood and tissues and inhibit their degranulation, suggesting that sputum eosinophilia could be a good predictor of response to inhaled corticosteroids 11 . (ersjournals.com)
  • The authors also examined whether percentage of sputum eosinophils was a predictor of short-term response to inhaled corticosteroids and they investigated whether neutrophil counts were increased in asthmatics without sputum eosinophilia compared with asthmatics with sputum eosinophilia. (ersjournals.com)
  • Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 5×108/L (500/μL). (wikipedia.org)
  • An absolute eosinophil count is not generally needed if the CBC shows marked eosinophilia. (wikipedia.org)
  • Using a provisional case definition of eosinophil count of greater than or equal to 2000 cells per mm3 and absence of documentation in the clinical record of any known cause of eosinophilia (e.g., parasitic or fungal infection, end-stage renal disease, leukemia, allergic disorder, and drug reactions), NMDHE initiated an active search for additional cases through review of laboratory records of eosinophil counts. (cdc.gov)
  • Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 5.0 × 10 8 /l (500/μL). (wikipedia.org)
  • Eosinophilia is defined as an absolute eosinophil count greater than 2SD above the mean for the population being tested. (oncologynurseadvisor.com)
  • In our laboratory, an absolute eosinophil count of greater than 2.0 x [10.sup.9]/L is defined as marked eosinophilia. (thefreelibrary.com)
  • Eosinophilia is the technical name for an increased eosinophil count. (verywellhealth.com)
  • Eosinophilia is suggestive of allergy , but not necessarily of food allergy, although food allergies have been responsible for a some cases of an increased eosinophil count. (digitalnaturopath.com)
  • Eosinophilia is defined as a peripheral blood eosinophil count greater than 350 per mm3. (pharmaceutical-journal.com)
  • Eosinophilia is an expansion of eosinophil numbers in the blood, due to either a reactive process, such as an allergic reaction or parasitic infection (secondary eosinophilia), or to a neoplastic process that involves clonal eosinophils or their precursors (primary eosinophilia). (arupconsult.com)
  • Pleural fluid eosinophilia (PFE), with eosinophil values greater than 10% of nucleated cells, is seen in approximately 10% of pleural effusions and is not correlated with peripheral blood eosinophilia. (medscape.com)
  • Allergic reactions to drugs are a common cause of eosinophilia, with manifestations ranging from diffuse maculopapular rash , to severe life-threatening drug reactions with eosinophilia and systemic symptoms (DRESS). (wikipedia.org)
  • Drug rash with eosinophilia and systemic symptoms (DRESS) is a type of drug allergy which can occur as a reaction to a large variety of medications. (aaaai.org)
  • Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: a retrospective cohort study from Taiwan. (aaaai.org)
  • Drug reaction with eosinophilia and systemic symptoms (DRESS) is characterized by fever, skin rash, hematological abnormalities, and systemic involvement such as hepatitis. (hindawi.com)
  • Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially fatal drug reaction characterized by fever, a skin rash, hematological abnormalities including eosinophilia or abnormal lymphocytes and systemic involvement including hepatitis, interstitial nephritis or pneumonitis [ 2 ]. (hindawi.com)
  • These images are a random sampling from a Bing search on the term "Drug Reaction with Eosinophilia and Systemic Symptoms. (fpnotebook.com)
  • The most severe form is called drug reaction with eosinophilia and systemic symptoms (DRESS). (verywellhealth.com)
  • 2013) Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Original Multisystem Adverse Drug Reaction. (scirp.org)
  • Chen, Y.C., Chui, H.C. and Chu, C.Y. (2010) Drug Reaction with Eosinophilia and Systemic Symptoms: A Retrospective Study of 60 Cases. (scirp.org)
  • 2001) Association of Human Herpesvirus 6 Infection with Drug Reaction with Eosinophilia and Systemic Symptoms. (scirp.org)
  • 2010) Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Multiorgan Antiviral T Cell Response. (scirp.org)
  • S ndrome de DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) por sulfonamidas. (medigraphic.com)
  • Descamps V, Valance A, Edlinger C, Fillet AM, Grossin M, Lebrun-Vignes B, Belaich S, Crickx B. Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms. (medigraphic.com)
  • If primary eosinophilia remains likely, then the next steps are histopathologic analysis of a bone marrow biopsy and cytogenetic analysis. (arupconsult.com)
  • In summary, this double-blind, placebo-controlled six-week trial of aerosolized fluticasone in the treatment of EoE found the treatment efficacious at decreasing esophageal eosinophilia and eosinophil activity," the authors write. (empr.com)
  • Over the 80's and early 90's, dense esophageal eosinophilia was mostly associated gastroesophageal reflux disease (GERD). (isciii.es)
  • For the next 15 years, EoE and GERD were rigidly considered separate entities: Esophageal eosinophilia with pathological acid exposure on pH monitoring or response to proton pump inhibitor (PPI) therapy was GERD, whereas normal pH monitoring or absence of response to PPIs was EoE. (isciii.es)
  • Severity of esophageal eosinophilia predicts response to conventional gastroesophageal reflux therapy. (semanticscholar.org)
  • Rarer symptoms of eosinophilia can include weight loss, night sweats, lymph node enlargement, other skin rashes, and numbness and tingling due to nerve damage. (netdoctor.co.uk)
  • Strongyloides infection can persist for years without prominent symptoms and should be suspected in any patient with unexplained eosinophilia. (nih.gov)
  • Approach to the patient with unexplained eosinophilia. (mayoclinic.org)
  • [4] The presence of eosinophilia is a core feature of EMS, along with unusually severe myalgia (muscle pain). (wikipedia.org)
  • We present the case of a 70-year old Patient with diffuse abdominal pain, severe eosinophilia, and increased liver parameters hospitalized for further evaluation. (nih.gov)
  • I underwent medical tests in my college, which stated that I have severe eosinophilia . (ndtv.com)
  • Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. (curehunter.com)
  • describe a patient treated with clozapine who had severe eosinophilia (55% of WBCs) followed by neutropenia (neutrophil count of 1840/μL) 7 days later. (psychiatrist.com)
  • Unless very severe, the severity of eosinophilia is solely related to the allergic responses that accompany it. (pharmaceutical-journal.com)
  • Eosinophilia can be idiopathic (primary) or, more commonly, secondary to another disease. (wikipedia.org)
  • Secondary eosinophilia is also called reactive eosinophilia. (unboundmedicine.com)
  • The blood film was then reviewed by a haematologist who commented that it was consistent with secondary eosinophilia and leukamoid reaction, whilst bone marrow infiltration might also be involved. (thefreelibrary.com)
  • A broad range of conditions can result in secondary/reactive eosinophilia. (arupconsult.com)
  • Workup for primary/neoplastic eosinophilia should be pursued when secondary/reactive eosinophilia has been ruled out, or if indicated by hematologic signs, such as cytopenias or abnormal blood smear, and/or other specific signs or symptoms, such as fever or mucosal ulcers. (arupconsult.com)
  • Primary and secondary eosinophilia can be managed by treating the underlying cause. (palmswesthospital.com)
  • The former (secondary eosinophilia) can be found in a variety of hematologic malignancies including Hodgkin's disease and lymphomas, predominantly of T-cell phenotype. (haematologica.org)
  • Eosinophilia can accompany a range of disorders from benign diseases, to eosinophilias with organ damage, to eosinophil neoplasms. (arupconsult.com)
  • Given the broad array of diseases associated with eosinophilia, a variety of presentations may prompt testing. (arupconsult.com)
  • Available at: http://www.netdoctor.co.uk/diseases/facts/eosinophilia.htm. (palmswesthospital.com)
  • Many herbs with anti-allergic uses and immunomodulator properties have been found to be very useful in chronic eosinophilia and other allergic diseases. (planetayurveda.com)
  • This information refers to the general prevalence and incidence of these diseases, not to how likely they are to be the actual cause of Eosinophilia. (rightdiagnosis.com)
  • Used in a number of home remedies for various medicinal issues, ginseng can also be used for eosinophilia due to its reported ability to help reduce inflammation. (doctorshealthpress.com)
  • Parasite infections: Worldwide the most common cause of eosinophilia is a parasite infection. (verywellhealth.com)
  • Furthermore excessive histamine activity has been linked blood eosinophilia and myalgia. (bionity.com)
  • Travelers' diarrhea is a type of parasite infection but is not commonly associated with eosinophilia. (verywellhealth.com)
  • Rash and eosinophilia with Tamoxifen? (medhelp.org)
  • Is a rash on the back, swelling in the legs, and eosinophilia of 21.4 caused by Tamoxifen? (medhelp.org)
  • Generalized rash and eosinophilia may be seen with almost any medication, although antibiotics are the most frequent cause. (oncologynurseadvisor.com)
  • If you get an accurate diagnosis and can receive treatment for any relevant conditions or disorders, the eosinophilia will likely resolve. (mayoclinic.org)
  • Eosinophilia and eosinophil-related disorders. (medlineplus.gov)
  • Like most blood disorders, eosinophilia is identified on complete blood count (CBC) . (verywellhealth.com)
  • Eosinophilia is commonly observed in a wide range of disparate non-clonal and clonal disorders. (haematologica.org)
  • Network of tyrosine kinase fusion genes in eosinophilia-associated chronic myeloproliferative disorders. (haematologica.org)
  • There are a variety of disorders that can cause eosinophilia ranging from simple hay fever to life threatening tumor. (planetayurveda.com)
  • Monitoring should include assessment for possible end-organ damage because any organ system can be affected by persistent eosinophilia. (arupconsult.com)
  • 4 , 5 However, this fusion is only seen in approximately 10% of cases with persistent unexplained eosinophilia, and most of the other fusions, all of which are associated with visible cytogenetic abnormalities, are considerably less common. (haematologica.org)
  • Familial eosinophilia is a rare congenital disorder characterized by the presence of sustained elevations in blood eosinophil levels that reach ranges diagnostic of eosinophilia (i.e. 500-1500/microliter) or, far more commonly, hypereosinophilia (i.e. >1,500/microliter). (wikipedia.org)
  • Individuals with familial eosinophilia exhibit hypereosinophilia presumably from birth (earliest documentation at 4 months of age). (wikipedia.org)
  • Familial dysphagia and eosinophilia. (omicsonline.org)
  • A family history increases your chance of familial eosinophilia. (palmswesthospital.com)
  • If there is no direct evidence of a neoplastic process, a thorough patient history and physical examination is the next step in the evaluation of eosinophilia. (oncologynurseadvisor.com)
  • In the intrinsic type of eosinophilia, treating the primary illness that caused the lung condition is usually the option. (wisegeek.com)
  • The cause will vary based on the type of eosinophilia. (palmswesthospital.com)
  • The degree of eosinophilia is not a reliable predictor of eosinophil-mediated organ damage. (unboundmedicine.com)
  • and the relationship between specific helminthic infections, country of origin, and degree of eosinophilia. (cdc.gov)
  • The presentation and evaluation of eosinophilia may be similar across age groups (children, adolescents, and adults). (arupconsult.com)
  • Diagnosis of eosinophilia is via a complete blood count (CBC), but diagnostic procedures directed at the underlying cause vary depending on the suspected condition(s). (wikipedia.org)
  • These individuals are generally detected on routine blood cell counts and at the time of diagnosis present without symptoms or at least no symptoms related to their eosinophilia. (wikipedia.org)
  • Tefferi A. Blood Eosinophilia: A New Paradigm in Disease Classification, Diagnosis and Treatment. (palmswesthospital.com)
  • To determine whether aerosolized fluticasone therapy improved symptomatic dysphagia and histologic eosinophilia, Jeffrey A. Alexander, MD, of the Mayo Clinic College of Medicine in Rochester, MN, and colleagues conducted a randomized, double-blind, placebo-controlled trial involving adults (mean age, 37.5 years) with a new diagnosis of EoE. (empr.com)
  • Specific treatments are dictated by the causative condition, though in idiopathic eosinophilia, the disease may be controlled with corticosteroids. (wikipedia.org)
  • The presence of atypical eosinophils, blasts, immature granulocytes, dysplastic red cells, leukocytes or platelets, lymphocytosis, and/or atypical lymphocytes suggests the presence of either a clonal marrow or lymphoproliferative disorder as the cause of eosinophilia. (oncologynurseadvisor.com)
  • In rare cases, a hematologic disorder underlies sustained eosinophilia which can be either non-clonal or clonal. (haematologica.org)
  • [2] In primary cutaneous T cell lymphoma, blood and dermal eosinophilia are often seen. (wikipedia.org)
  • The most common medications associated with eosinophilia include antibiotics (penicillin, cephalosporins), non-steroidal anti-inflammatory medications (aspirin, ibuprofen), ranitidine (for gastroesophageal reflux), phenytoin (anti-seizure) and allopurinol (used to treat gout). (verywellhealth.com)
  • The term eosinophilia refers to conditions in which abnormally high amounts of eosinophils are found in either the blood or in body tissues. (netdoctor.co.uk)
  • Eosinophilia in the bloodstream is diagnosed from a simple blood test. (netdoctor.co.uk)
  • Blood eosinophilia may be detected with a blood test, usually as part of a complete blood count. (mayoclinic.org)
  • A count of more than 500 eosinophils per microliter of blood is generally considered eosinophilia in adults. (mayoclinic.org)
  • Eosinophilia is usually found when your doctor has ordered blood tests to help diagnose a condition you're already experiencing. (mayoclinic.org)
  • In allergic rhinitis, increased nasal eosinophilia is more common than peripheral blood eosinophilia. (unboundmedicine.com)
  • It is associated with peripheral blood eosinophilia. (unboundmedicine.com)
  • Affected individuals have elevated levels of certain white blood cells known as eosinophils in the various tissues of the body, a condition known as eosinophilia. (rarediseases.org)
  • Renal and liver function tests and C reactive protein were within normal limits, but a peripheral blood eosinophilia was noted (2.1×10 9 /l). (bmj.com)
  • In a patient without an obvious cause for eosinophilia (e.g., allergic symptoms), it is probably most appropriate to simply repeat a complete blood count (CBC) on a new sample to confirm that eosinophilia is truly present. (oncologynurseadvisor.com)
  • Over the following years, she had several top-up transfusions and developed moderate thrombocytopenia of 80-100 x [10.sup.9]/L. Until the presentation of this event, an elevated white cell count (22.7-36.3 x [10.sup.9]/L) and eosinophilia ranging from 14% to 36% were frequent findings in her blood count. (thefreelibrary.com)
  • The workup should be clinically driven to determine cause and should take into account the magnitude of peripheral blood eosinophilia and the effect of eosinophilia on major organs. (arupconsult.com)
  • Eosinophilia is an abnormally high number of these white blood cells. (palmswesthospital.com)
  • Eosinophilia refers to a health condition resulting due to presence of excessive eosinophils (type of white blood cell) in blood or body tissues. (planetayurveda.com)
  • On an average around 5% to 7% of white blood cells constitute eosinophils but if you have a higher count then it means that you either have borderline eosinophilia or actual progressing eosinophilia that can cause significant health hazards. (planetayurveda.com)
  • A doctor must diagnose eosinophilia, usually through a blood test that will measure of the amount of eosinophils in your bloodstream. (doctorshealthpress.com)
  • A correlation between airway hyperresponsiveness and blood 4 or airway 5 eosinophilia has been reported. (ersjournals.com)
  • What is the role of pleural fluid eosinophilia in the workup for pleural effusion (fluid on the lungs)? (medscape.com)
  • Collectively, these results indicate that chitin-induced innate immune responses down-regulate Th2-facilitated IgE production and lung eosinophilia in the allergic mouse. (jimmunol.org)
  • Tropical eosinophilia is considered a manifestation of a species of microfilaria. (wikipedia.org)
  • Eosinophilia, particularly marked eosinophilia, is a phenomenon commonly associated with allergy, parasitic infestations and drug hypersensitivities, but rarely linked to pre-existing solid tumors. (thefreelibrary.com)
  • Eosinophilia accompanying immunodeficiency commonly presents in infancy. (arupconsult.com)