A malignant epithelial tumor with a glandular organization.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the LUNG.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Tumors or cancer of the ESOPHAGUS.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Tumors or cancer of the STOMACH.
That part of the STOMACH close to the opening from ESOPHAGUS into the stomach (cardiac orifice), the ESOPHAGOGASTRIC JUNCTION. The cardia is so named because of its closeness to the HEART. Cardia is characterized by the lack of acid-forming cells (GASTRIC PARIETAL CELLS).
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the COLON.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A cell line derived from cultured tumor cells.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Tumors or cancer of the INTESTINES.
Tumors or cancer of the PROSTATE.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tumors or cancer of the DUODENUM.
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Tumors or cancer of the CECUM.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
A condition in which there is a change of one adult cell type to another similar adult cell type.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Tumors or cancer of the RECTUM.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).
A benign epithelial tumor with a glandular organization.
The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.
DNA present in neoplastic tissue.
Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Tumors or cancer of the PARANASAL SINUSES.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Surgical removal of the pancreas. (Dorland, 28th ed)
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumors or cancer of the UTERINE CERVIX.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Tumors or cancer of the APPENDIX.
Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Tumors or cancer of the gallbladder.
Tumors or cancer of the SIGMOID COLON.
Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)
Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Sialylated Lewis blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.
Tumors or cancer of the UTERUS.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Elements of limited time intervals, contributing to particular results or situations.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Transplantation between animals of different species.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
RNA present in neoplastic tissue.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Antimetabolites that are useful in cancer chemotherapy.
Endoscopic examination, therapy or surgery of the esophagus.
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
A pair of anal glands or sacs, located on either side of the ANUS, that produce and store a dark, foul-smelling fluid in carnivorous animals such as MEPHITIDAE and DOGS. The expelled fluid is used as a defensive repellent (in skunks) or a material to mark territory (in dogs).
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Antibodies produced by a single clone of cells.
Metastases in which the tissue of origin is unknown.
Inhaling and exhaling the smoke of burning TOBACCO.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
Biochemical identification of mutational changes in a nucleotide sequence.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.
Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.
A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Excision of the uterus.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
An embryonic structure originating from the ALLANTOIS. It is a canal connecting the fetal URINARY BLADDER and the UMBILICUS. It is normally converted into a fibrous cord postnatally. When the canal fails to be filled and remains open (patent urachus), urine leaks through the umbilicus.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Tumors or cancer of the LIVER.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.
Neoplasms composed of more than one type of neoplastic tissue.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Tumors or cancer of the NOSE.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Tumors or cancer of the SALIVARY GLANDS.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Tumors or cancer of the BILE DUCTS.
A BETARETROVIRUS that causes pulmonary adenomatosis in sheep (PULMONARY ADENOMATOSIS, OVINE).
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Tumors or cancer of the DIGESTIVE SYSTEM.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Tumors or cancer of the VAGINA.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Retrograde flow of duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the STOMACH.
Rare subtypes include pulmonary enteric adenocarcinoma. Nearly 40% of lung cancers are adenocarcinoma, which usually comes from ... Although most cases of adenocarcinoma are associated with smoking, adenocarcinoma is also the most-common form of lung cancer ... Pulmonary enteric adenocarcinoma: a study of the clinicopathologic and molecular status of nine cases Int J Clin Exp Pathol 7(3 ... increasing particle deposition in small airways where adenocarcinoma tends to arise. Rates of lung adenocarcinoma continues to ...
Enteric (typhoid) fever (Salmonella enterica var. typhii) and paratyphoid fever Bacillus cereus Clostridium perfringens (gas ... gangrene) Viral infections Rotavirus Norovirus Astrovirus Adenovirus Calicivirus Neoplasms (cancers) Adenocarcinoma Carcinoid ... atresia Hirschsprung's disease Meckel's diverticulum Pyloric stenosis Pancreas divisum Ectopic pancreas Enteric duplication ...
... is rare subtype of pulmonary adenocarcinoma. The presentation is similar to that of other lung ... Lin D, Zhao Y, Li H, Xing X (2013) Pulmonary enteric adenocarcinoma with villin brush border immunoreactivity: a case report ... Lin, D; Zhao, Y; Li, H; Xing, X (2013). "Pulmonary enteric adenocarcinoma with villin brush border immunoreactivity: A case ... Journal of Thoracic Disease 5:E17-20 Tsao MS, Fraser RS (1991) Primary pulmonary adenocarcinoma with enteric differentiation. ...
Koppert L, Wijnhoven B, van Dekken H, Tilanus H, Dinjens W (2005). The molecular biology of esophageal adenocarcinoma. J Surg ... Proton pump inhibitor use and enteric infections. Am J Gastroenterol. 2009 Mar. 104 Suppl 2:S10-6. [Medline]. ... Koppert L, Wijnhoven B, van Dekken H, Tilanus H, Dinjens W (2005). The molecular biology of esophageal adenocarcinoma. J Surg ...
Ishikawa, T (14 May 2008). "Chemotherapy with enteric-coated tegafur/uracil for advanced hepatocellular carcinoma". World ... specifically adenocarcinoma, typically with uracil) Colorectal (usually when combined with gimeracil and oteracil) Head and ...
Reovirus, an acronym for Respiratory Enteric Orphan virus, generally infects mammalian respiratory and bowel systems. Most ... and chemotherapy in patients with advanced or metastatic pancreatic adenocarcinoma who have failed, or did not tolerate, first ...
Enteric neuropathy: alternative name sometimes used for diagnosis in UK Stanghellini V, Cogliandro RF, De Giorgio R, et al. ( ... Sharma S, Ghoshal UC, Bhat G, Choudhuri G (November 2006). "Gastric adenocarcinoma presenting with intestinal pseudoobstruction ... The term may be used synonymously with enteric neuropathy if a neurological cause is suspected. Clinical features of intestinal ...
They are used in blood tests for diagnosis of enteric fever. Goldberg, Richard J. (1952). "A Theory of Antibody-Antigen ... "Identification of Cytosolic Antigens from GW-39 Adenocarcinoma Cells by Crossed Immunoelectrophoresis and Immunofluorescence". ...
The other main type is an adenocarcinoma that occurs in the glands or columnar tissue of the esophagus. This is most common in ... The submucosa also contains the submucosal plexus, a network of nerve cells that is part of the enteric nervous system. The ...
They reported abnormalities of the enteric nervous system and estrogen receptors. One study concluded that intussusception of ... polyps endometriosis inflammatory granulomas infectious disorders drug-induced colitis mucus-producing adenocarcinoma ... "An assessment of enteric nervous system and estroprogestinic receptors in obstructed defecation associated with rectal ...
Importantly, the deletion of ARNTL in ILC3s using a RORc promoter disrupted enteric defence, reinforcing the role of clock ... "A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma". Cell. 177 (3): 572-586.e22. doi:10.1016/j.cell.2019.03. ... Conversely, it has also been demonstrated that RORγt+ enteric ILC3s themselves are under circadian control, being entrained by ...
Reoviruses generally infect mammalian respiratory and bowel systems (the name deriving from an acronym, respiratory enteric ... "Infectivity-enhanced cyclooxygenase-2-based conditionally replicative adenoviruses for esophageal adenocarcinoma treatment". ...
The other main type is an adenocarcinoma that occurs in the glands or columnar tissue of the esophagus. This is most common in ... a network of nerve cells that is part of the enteric nervous system.[18] ...
Pulmonary enteric adenocarcinoma is rare subtype of pulmonary adenocarcinoma. The presentation is similar to that of other lung ... Lin D, Zhao Y, Li H, Xing X (2013) Pulmonary enteric adenocarcinoma with villin brush border immunoreactivity: a case report ... Lin, D; Zhao, Y; Li, H; Xing, X (2013). "Pulmonary enteric adenocarcinoma with villin brush border immunoreactivity: A case ... Journal of Thoracic Disease 5:E17-20 Tsao MS, Fraser RS (1991) Primary pulmonary adenocarcinoma with enteric differentiation. ...
Innate Immune Inflammatory Response against Enteric Bacteria Helicobacter hepaticus Induces Mammary Adenocarcinoma in Mice. ... Innate Immune Inflammatory Response against Enteric Bacteria Helicobacter hepaticus Induces Mammary Adenocarcinoma in Mice ... Innate Immune Inflammatory Response against Enteric Bacteria Helicobacter hepaticus Induces Mammary Adenocarcinoma in Mice ... Innate Immune Inflammatory Response against Enteric Bacteria Helicobacter hepaticus Induces Mammary Adenocarcinoma in Mice ...
Enteric Adenocarcinoma Arising From a Bronchogenic Cyst Adenocarcinoma de tipo entérico originado a partir de un quiste ... Definitive histology of the specimen was infiltrating colloid adenocarcinoma with immunophenotype of enteric adenocarcinoma ... To the best of our knowledge, this is the first case of bronchogenic cysts associated with an enteric adenocarcinoma and, in ... To the best of our knowledge, this is the first case of enteric adenocarcinoma arising from an intrapulmonary bronchogenic cyst ...
... or pulmonary adenocarcinoma with enteric differentiation (PAED) is an extremely rare variant of primary invasive adenocarcinoma ... Pulmonary enteric adenocarcinoma (PEAC) or pulmonary adenocarcinoma with enteric differentiation (PAED) is an extremely rare ... Primary pulmonary enteric adenocarcinoma. Dr Ian Bickle ◉ and Dr Yuranga Weerakkody ◉ et al. ... Pulmonary enteric adenocarcinoma: a study of the clinicopathologic and molecular status of nine cases. (2014) International ...
... and colorectal adenocarcinoma (CRAC), making the differential diagnosis difficult. At present there are only limited studies ... Primary pulmonary enteric adenocarcinoma (PEAC) is an extremely rare variant of invasive lung cancer. It is highly ... heterogeneous while shares some common morphologic and immunohistochemical features with usual pulmonary adenocarcinoma (PAC) ... OR lung enteric adenocarcinoma [Title/Abstract]) OR enteric-type adenocarcinoma of the lung [Title/Abstract]) OR Intestinal ...
Pulmonary intestinal-type adenocarcinoma does not show enteric differentiation by immunohistochemical study *Samuel A Yousem ... Rights & permissionsfor article Pulmonary intestinal-type adenocarcinoma does not show enteric differentiation by ... Rights & permissionsfor article Role of molecular studies in the diagnosis of lung adenocarcinoma . Opens in a new window. ... Role of molecular studies in the diagnosis of lung adenocarcinoma *Samuel A Yousem ...
László, T., Lacza, Á., Tóth, D., Molnár, T. F., & Kálmán, E. (2014). Pulmonary enteric adenocarcinoma indistinguishable ... László, T, Lacza, Á, Tóth, D, Molnár, TF & Kálmán, E 2014, Pulmonary enteric adenocarcinoma indistinguishable morphologically ... T1 - Pulmonary enteric adenocarcinoma indistinguishable morphologically and immunohistologically from metastatic colorectal ... title = "Pulmonary enteric adenocarcinoma indistinguishable morphologically and immunohistologically from metastatic colorectal ...
Pulmonary adenocarcinoma with enteric differentiation (PAED) is a rare subtype of lung adenocarcinoma recently recognized in ... N2 - Pulmonary adenocarcinoma with enteric differentiation (PAED) is a rare subtype of lung adenocarcinoma recently recognized ... AB - Pulmonary adenocarcinoma with enteric differentiation (PAED) is a rare subtype of lung adenocarcinoma recently recognized ... abstract = "Pulmonary adenocarcinoma with enteric differentiation (PAED) is a rare subtype of lung adenocarcinoma recently ...
Enteric Differentiation in Endometrial Adenocarcinomas: A Mucin Histochemical Study. McCluggage, W. G.; Roberts, N.; Bharucha, ... Endometrial Adenocarcinoma with Choriocarcinomatous Differentiation in an Elderly Virginal Woman. Kalir, Tamara; Seijo, Laura; ... Endometrial Adenocarcinoma of Endometrioid Subtype with Squamous Differentiation: An Immunohistochemical Study of MIB-1 (ki-67 ... Surface Epithelial Changes in Endometrial Adenocarcinoma: Diagnostic Pitfalls in Curettage Specimens. Jacques, Suzanne M.; ...
Rare subtypes include pulmonary enteric adenocarcinoma. Nearly 40% of lung cancers are adenocarcinoma, which usually comes from ... Although most cases of adenocarcinoma are associated with smoking, adenocarcinoma is also the most-common form of lung cancer ... Pulmonary enteric adenocarcinoma: a study of the clinicopathologic and molecular status of nine cases Int J Clin Exp Pathol 7(3 ... increasing particle deposition in small airways where adenocarcinoma tends to arise. Rates of lung adenocarcinoma continues to ...
We previously reported that mucinous adenocarcinoma and adenocarcinoma NOS could be referred to as enteric type adenocarcinoma ... In particular, colonic adenocarcinoma and pulmonary enteric type adenocarcinoma might be difficult to differentiate from ... Thymic adenocarcinoma, enteric type. Pericardial effusion. Metastatic carcinoma, showing glandular clusters of atypical cells. ... Thymic adenocarcinoma, enteric type. 2. M. 50. 20 PY. Angina. IVB. Supraclavicular LN. Metastatic carcinoma, showing glandular ...
Primary pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of primary lung adenocarcinoma. However, it is not known ... and oncogenic features of primary pulmonary enteric adenocarcinoma in comparison with invasive adenocarcinoma in resection ... and oncogenic features of primary pulmonary enteric adenocarcinoma in comparison with invasive adenocarcinoma in resection ... and oncogenic features of primary pulmonary enteric adenocarcinoma in comparison with invasive adenocarcinoma in resection ...
Pulmonary adenocarcinoma with enteric differentiation is a rare variant defined as a tumor with more than 50% of colorrectal- ... Case Series: Patients were identified in a review of a set of adenocarcinomas, apparently originated in colon, but posteriorly ... Microscopic description revealed a lepidic (mucinous) adenocarcinoma in all five cases. Immunohistochemistry were positive for ... analysis can distinguish between metastatic colorectal carcinoma and primary pulmonary adenocarcinoma with enteric ...
Surgical Case of Pulmonary Enteric Adenocarcinoma].. Shomura S, Suzuki H, Yada M, Kondo C. ...
Enteric type urachal adenocarcinoma: a case report.. El Demellawy D, Nasr A, Alowami S, Escott N. ... Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma: A rare case report ... Fine Needle Aspiration Cytology Diagnosis of an Urachal Adenocarcinoma.. Thirunavukkarasu B, Mridha AR, Yadav S, Kumar R, ... A case of metastatic pulmonary cancer from urachal carcinoma that required differentiation from primary lung adenocarcinoma]. ...
This positive staining indicated the tumor enteric type characters. In order to exclude the possibility of the metastasis from ... Primary Villoglandular Mucinous Adenocarcinoma of the Vulva. Akiko Matsuzaki,1,2 Masanao Saio,1,2 Noritake Kosuge,1,2 Hajime ... Primary villoglandular mucinous adenocarcinoma of the vulva is rare tumor. We report a case of 68-year-old woman who developed ...
1) Bladder adenocarcinoma had high ERBB2 and EGFR and, from a drug resistance standpoint, high BRCP and MRP1. 2) Urachal ... Always has enteric-type histology. - Treatment: One of the few cases of bladder cancer in which partial cystectomy is ... 3) Bladder Adenocarcinoma. a. ,2% of all bladder cancers. b. Risk factors: infection, history of bladder exstrophy/repair, ... e. Urachal adenocarcinoma (unique subset). - Younger patients, equal male:female distribution. - Develops in the urachal ...
Enteric. References. *↑ 1.0 1.1 Hawkey CM (1974). "The relationship between blood coagulation and thrombosis and ... adenocarcinoma in situ, minimally invasive adenocarcinoma, invasive adenocarcinoma, and variants of invasive adenocarcinoma. ... American Roentgen Ray Society Images of Adenocarcinoma of the lung classification All Images. X-rays. Echo & Ultrasound. CT ... Adenocarcinoma of the lung may be classified according to WHO into mixed, acinar, papillary, bronchioloalveolar carcinoma, and ...
May also have enteric morphology (looks like colorectal adenocarcinoma).. *Other morphologies include signet ring cell, which ... Similar immunohistochemical staining (CDX2+, CK7+ and β-catenin-) with urachal adenocarcinoma.. *Treated by en bloc resection ... Absence of florid cystitis glandularis in bladder surface (exclude precursor lesions of primary bladder adenocarcinoma) ... can diffusely spread into the bladder, and adenocarcinoma, not otherwise classifiable, or a mixed of these different patterns. ...
Lung adenocarcinoma (LA) is the most common cause of cancer-related death worldwide. Despite the advances over last decade in ... colloid adenocarcinoma; foetal adenocarcinoma; enteric adenocarcinoma; minimally invasive adenocarcinoma, with two types: ... lipidic adenocarcinoma; acinar adenocarcinoma; papillary adenocarcinoma; micropapillary adenocarcinoma; solid adenocarcinoma; ... invasive mucinous adenocarcinoma, with its variants mixed invasive mucinous and non-mucinous adenocarcinoma; ...
Enteric adenocarcinoma: *Consists of an adenocarcinoma that morphologically resembles colonic adenocarcinoma with back-to-back ... Histologically adenocarcinoma is divided in to following subtypes:[36][37][38][39][40][41] *Lepidic adenocarcinoma. ... Fetal adenocarcinoma: *Fetal adenocarcinoma consists of malignant glandular cells growing in tubules and papillary structures ... Minimally invasive adenocarcinoma (MIA) *Nonmucinous (MIA): *This subpleural adenocarcinoma tumor consists primarily of lepidic ...
Several morphologic patterns such as enteric (looks like colorectal adenocarcinoma!) (image B), (image C), & (image D), ... Immunohistochemistry: expresses enteric marker CDX2, but unlike colorectal adenocarcinoma has more CK7+ and is nuclear β- ... There are 2 general types of adenocarcinomas in the bladder: *Those arising from the urachus (urachal adenocarcinoma, ~1/3), ... Primary adenocarcinoma of the bladder overall is rare, and accounts for only 1% of bladder carcinomas. ...
Turkey enteric Coronavirus (TCV) is one of the major causes of epidemic diarrhoea in turkey poults (1, 2). The morphological ... Cultural and antigenic properties of newly established cell strains derived from adenocarcinomas of the human colon and rectum ... Identification of the structural proteins of turkey enteric Coronavirus. Arch. Virol. 99: 173 (1988).PubMedCrossRefGoogle ... Turkey enteric Coronavirus (TCV) is one of the major causes of epidemic diarrhoea in turkey poults (1, 2). The morphological ...
Abstract Enteric duplication cysts (EDCs) are rare congenital malformations formed during the embryonic development of the ... Ribaux C, Meyer P (1995) Adenocarcinoma in a ileal duplication. Ann Pathol 15:443-445PubMedGoogle Scholar ... Enteric duplication cysts (EDCs) are rare congenital anomalies found anywhere along the gastrointestinal tract (GT) from the ... Van Zitteren LM, Ruppert M, Op de Beeck B, Wojciechowski M (2017) Infected enteric duplication cyst. BMJ Case Rep 21:2017Google ...
Adenocarcinoma is the most common type of lung cancer in contemporary series, accounting for approximately (...) ... Other variants of invasive adenocarcinoma include colloid, fetal, and enteric adenocarcinoma.. For lesions without identifiable ... pulmonary signet ring adenocarcinoma pulmonary mixed adenocarcinoma pulmonary fetal adenocarcinoma. * low-grade adenocarcinoma ... pulmonary solid adenocarcinoma pulmonary clear cell adenocarcinoma pulmonary mucinous adenocarcinoma (colloid) pulmonary ...
... consisting of both villous adenoma and mucinous adenocarcinoma of the urachus. The tumor was incidentally discovered during ... Villous adenomas have been reported as papillary enteric adenoma or villous tumor. The origin may be from the urachus or caused ... Urachal malignant tumors have been classified as mucin-positive adenocarcinoma (69%), mucin-negative adenocarcinoma (15%), ... Mucinous adenocarcinoma of the urinary bladderJournal of UrologyYear: 19551196871. 3. Herr HW. Urachal carcinoma: the case for ...
2009) Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma ... 1998) GDNF and ET-3 differentially modulate the numbers of avian enteric neural crest cells and enteric neurons in vitro. Dev ... NADPH-d myenteric neuron fibers have a higher density around enteric ganglia in GFAP-Gdnf mice (E) than WT animals (A), but ... GFAP-Gdnf mice produce excess GDNF in CNS and enteric glia. Gdnf+/− mice were a generous gift from Genentech (Moore et al., ...
This is a rare case in which an adenocarcinoma arise from an enteric cyst in the mediastinum.. ... During a left lower lobectomy an enteric cyst in the posterior mediastinum involving lung was found. This cyst in the lung ... contained normal gastric parietal cells and pancreatic tissue, and was surrounded by adenocarcinoma characteristic of gastric ...
Enteric Adenocarcinoma Arising From a Bronchogenic Cyst. Mª Teresa Gómez-Hernández, Nuria Novoa, José Luis Aranda, Marcelo F. ...
... a clinicopathologic comparison with nonhereditary poorly differentiated enteric-type adenocarcinoma and neuroendocrine ... Medullary adenocarcinoma of the colon: clinicopathologic study of 11 cases. Hum Pathol. 1999;30:843-8.PubMedCrossRefGoogle ... PDA poorly differentiated adenocarcinoma, WDA well-differentiated adenocarcinoma, ECOG Eastern Cooperative Oncology Group ... ALK and ROS1 overexpression is very rare in colorectal adenocarcinoma. Appl Immunohistochem Mol Morphol. Epub 2 Jul 2014. doi: ...
  • Journal of Thoracic Disease 5:E17-20 Tsao MS, Fraser RS (1991) Primary pulmonary adenocarcinoma with enteric differentiation. (wikipedia.org)
  • Pulmonary enteric adenocarcinoma (PEAC) or pulmonary adenocarcinoma with enteric differentiation (PAED) is an extremely rare variant of primary invasive adenocarcinoma of the lung . (radiopaedia.org)
  • It is usually defined as a primary pulmonary adenocarcinoma where the enteric component exceeds 50% and with expression of at least 1 immunohistochemical marker of enteric differentiation. (radiopaedia.org)
  • Primary pulmonary adenocarcinoma with intestinal differentiation mimicking metastatic colorectal carcinoma: case report and review of literature. (radiopaedia.org)
  • 3. Hatanaka K, Tsuta K, Watanabe K, Sugino K, Uekusa T. Primary pulmonary adenocarcinoma with enteric differentiation resembling metastatic colorectal carcinoma: a report of the second case negative for cytokeratin 7. (radiopaedia.org)
  • For immunohistochemistry, primary PEAC expresses at least one of the enteric differentiation markers (CDX2, CK20, and MUC2). (biomedcentral.com)
  • Pulmonary adenocarcinoma with enteric differentiation (PAED) is a rare subtype of lung adenocarcinoma recently recognized in the WHO classification. (elsevier.com)
  • It is defined as an adenocarcinoma in which the enteric component exceeds 50% and have to show the expression of at least 1 immunohistochemical marker of enteric differentiation. (elsevier.com)
  • 4 ] and our institute [ 2 ] reported that both mucinous and NOS types showed enteric differentiation, suggesting that enteric type thymic adenocarcinoma could be an appropriate term in regards to the histology of this condition. (jpatholtm.org)
  • Pulmonary adenocarcinoma with enteric differentiation is a rare variant defined as a tumor with more than 50% of colorrectal-like components, immunohistochemistry (IHC) positive for at least one marker of enteric differentiation (CK20, CDX-2 or MUC2) and no evidence of other malignancies. (edoriumjournals.com)
  • The use of immunohistochemistry analysis can distinguish between metastatic colorectal carcinoma and primary pulmonary adenocarcinoma with enteric differentiation. (edoriumjournals.com)
  • Microscopic examination (hematoxylin and eosin) revealed an enteric differentiation that consisted in the presence of typical epithelial colonic cells (absorptive, globet, Paneth and enterocromafin cells). (edoriumjournals.com)
  • The patient was also submitted to an extensive screening for others neoplasms and negative results corroborated the diagnosis of a primary lung cancer with an enteric hystologic differentiation, posteriorly named pulmonary enteric adenocarcinoma (PEAC) [3] . (edoriumjournals.com)
  • A case of metastatic pulmonary cancer from urachal carcinoma that required differentiation from primary lung adenocarcinoma]. (nih.gov)
  • CASE PRESENTATION This is a case of primary adenocarcinoma with intestinal differentiation and focal mucin production in the thymus. (semanticscholar.org)
  • Clinicopathological, immunohistochemical, and mutational analyses of pulmonary enteric adenocarcinoma: usefulness of SATB2 and beta-catenin immunostaining for differentiation from metastatic colorectal carcinoma. (amedeo.com)
  • We report 2 cases of primary thymic adenocarcinoma with enteric differentiation. (naver.com)
  • The histology of the endobronchial lesion was mucinous adenocarcinoma of the lung. (archbronconeumol.org)
  • Based on histology, thymic adenocarcinoma is classified into four subtypes: mucinous, papillary, not otherwise specified (NOS), and a type with adenoid cystic carcinoma-like features [ 3 ]. (jpatholtm.org)
  • Microscopic description revealed a lepidic (mucinous) adenocarcinoma in all five cases. (edoriumjournals.com)
  • and preinvasive lesions: atypical adenomatous hyperplasia and adenocarcinoma in situ, which can be mucinous or non-mucinous [ 4 , 12 - 14 ]. (termedia.pl)
  • A Giant Mucinous Adenocarcinoma Arising within a Villous Adenoma of the Urachus: Case Report and Review of the Literature. (biomedsearch.com)
  • We present an exceptional case of a giant urachal tumor, consisting of both villous adenoma and mucinous adenocarcinoma of the urachus. (biomedsearch.com)
  • Mucinous cystic tumor with CK20 and CDX2 expression of the thymus: Is this a benign counterpart of adenocarcinoma of the thymus, enteric type? (semanticscholar.org)
  • Primary mucinous adenocarcinoma of the thymus: a case report and review of the literature. (semanticscholar.org)
  • Adenocarcinoma of the thymus: mucinous subtype. (semanticscholar.org)
  • Adenocarcinoma of the thymus: report of two cases, including a previously undescribed mucinous subtype. (semanticscholar.org)
  • Mucinous adenocarcinoma of the thymus: a distinct variant of thymic carcinoma. (semanticscholar.org)
  • The invasive mucinous adenocarcinoma subtype (formerly mucinous BAC) can have a variable appearance, including consolidation, air bronchograms, or multifocal subsolid nodules or masses 2 . (radiopaedia.org)
  • The differential diagnosis included other thymic carcinomas, yolk sac tumors, and metastatic adenocarcinoma from the lung or colorectum. (jpatholtm.org)
  • Primary thymic adenocarcinoma is a very rare neoplasm that accounts for 0.48% of all thymic epithelial tumors [ 1 ]. (jpatholtm.org)
  • There were a higher percentage of EGFR mutants versus wild-type tumors in invasive adenocarcinoma. (cdc.gov)
  • The talk focused on these four histologies: squamous cell carcinoma (SCC), neuroendocrine tumors, bladder adenocarcinoma (urachal adenocarcinoma), and glandular neoplasms. (urotoday.com)
  • Adenocarcinomas are highly heterogeneous tumors. (wikidoc.org)
  • Adenocarcinoma is the most common type of lung cancer found in non-smokers and is usually seen as a peripheral lesion in the lungs , as compared to centrally located tumors such as small cell lung cancer and squamous cell lung cancer. (wikidoc.org)
  • Urachal adenocarcinoma is extremely uncommon and accounts for 0.11%?0.34% of all bladder tumors. (biomedsearch.com)
  • 1] Malignant tumors, which account for about two-thirds of all primary small bowel tumors, consist of four primary subtypes: adenocarcinoma, carcinoid tumor, lymphoma, and sarcoma (or gastrointestinal [GI] stromal tumor). (cancernetwork.com)
  • These tumors are often included in series reporting peripancreatic malignancy, although it appears clear that their biology is different, ie, consistent with other enteric tumors. (cancernetwork.com)
  • The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Pancreatic Adenocarcinoma discuss the workup and management of tumors of the exocrine pancreas. (jnccn.org)
  • In the United States, approximately 90% of urinary tract tumors are urothelial in origin, with 1-7% of tumors represented by primary squamous cell carcinoma and another 2% being primary bladder adenocarcinomas. (iospress.com)
  • The other is the J-CAPP study that included 311 subjects with prior colorectal tumors (adenomas or early-stage adenocarcinomas), using the same aspirin enteric-coated tablets and placebo for 2 years ( 6 ). (aacrjournals.org)
  • This heterogeneity has brought changes in the classification of lung adenocarcinomas during the past several decades, as reflected in the World Health Organization (WHO) classification of lung tumors. (allenpress.com)
  • It is highly heterogeneous while shares some common morphologic and immunohistochemical features with usual pulmonary adenocarcinoma (PAC) and colorectal adenocarcinoma (CRAC), making the differential diagnosis difficult. (biomedcentral.com)
  • Primary PEACs were highly heterogeneous and shared some morphologic and immunohistochemical appearances with pulmonary adenocarcinoma (PAC) and colorectal adenocarcinoma (CRAC). (biomedcentral.com)
  • Although the definition of this tumor type is very important, above all in the differential diagnosis between a primary lung tumor and a metastasis of colorectal adenocarcinoma, this cancer still lacks a distinctive immunohistochemical and molecular signature. (elsevier.com)
  • May also have enteric morphology (looks like colorectal adenocarcinoma) . (auanet.org)
  • To our knowledge, only one case of colorectal adenocarcinoma metastasizing to the thymus gland has been documented, by Lee et al. (hindawi.com)
  • AMACR is frequently expressed in colorectal adenocarcinoma, but is rarely positive in small intestinal adenocarcinoma. (zeta-corp.com)
  • Pulmonary enteric adenocarcinoma is rare subtype of pulmonary adenocarcinoma. (wikipedia.org)
  • Comparison of thin-section CT and pathological findings in small solid-density type pulmonary adenocarcinoma: prognostic factors from CT findings. (semanticscholar.org)
  • Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. (semanticscholar.org)
  • Primary pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of primary lung adenocarcinoma. (cdc.gov)
  • Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide and adenocarcinoma subtype is the responsible for at least half of these cases [1] . (edoriumjournals.com)
  • Does lung adenocarcinoma subtype predict patient survival? (wikidoc.org)
  • This article brings a broad view over lung adenocarcinoma, for further details on each subtype, please refer to the specific articles listed below. (radiopaedia.org)
  • Hence, the preinvasive category of adenocarcinoma in situ, minimally invasive adenocarcinoma, and the invasive subtype of lepidic-predominant adenocarcinoma are often seen as a ground-glass nodule or a subsolid nodule with a predominant ground-glass component. (radiopaedia.org)
  • The terms BAC and mixed subtype adenocarcinoma are no longer used. (elsevier.com)
  • 7 The major changes are as follows: (1) the cessation of the use of the term bronchioloalveolar carcinoma, (2) the addition of a category of minimally invasive adenocarcinoma, and (3) the classification of invasive adenocarcinoma according to its predominant subtype. (allenpress.com)
  • Then, we evaluated the immunohistochemical and molecular profile of these adenocarcinomas. (elsevier.com)
  • Previous studies have focused on the diagnosis and classification of thymic adenocarcinoma according to its clinical, histologic, and immunohistochemical features. (jpatholtm.org)
  • Immunohistochemical staining of pulmonary enteric adenocarcinoma is here shown. (cdc.gov)
  • Similar immunohistochemical staining (CDX2+, CK7+ and β-catenin-) with urachal adenocarcinoma. (auanet.org)
  • This new adenocarcinoma classification is needed to provide uniform terminology and diagnostic criteria, especially for bronchioloalveolar carcinoma (BAC), the overall approach to small nonresection cancer specimens, and for multidisciplinary strategic management of tissue for molecular and immunohistochemical studies. (elsevier.com)
  • Fine Needle Aspiration Cytology Diagnosis of an Urachal Adenocarcinoma. (nih.gov)
  • Those arising from the urachus ( urachal adenocarcinoma , ~1/3), and those arising from the bladder itself (~2/3) (image A) . (auanet.org)
  • The indication for surgery was based on the typical imaging aspects, raising the suspicion of an underlying urachal adenocarcinoma (size and location). (biomedsearch.com)
  • Only three previous cases of urachal adenocarcinoma associated with villous adenoma have been described. (biomedsearch.com)
  • 7 ]. We describe a case of a urachal adenocarcinoma arising within in a villous adenoma of the bladder. (biomedsearch.com)
  • Lung adenocarcinoma has a complex variety of different hystopathologic subtypes with distinct epidemiology, pathology and prognosis. (edoriumjournals.com)
  • To address advances in oncology, molecular biology, pathology, radiology, and surgery of lung adenocarcinoma, an international multidisciplinary classification was sponsored by the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society. (semanticscholar.org)
  • Definitive histology of the specimen was infiltrating colloid adenocarcinoma with immunophenotype of enteric adenocarcinoma arising from a benign cystic mucoid lesion compatible with bronchogenic cyst. (archbronconeumol.org)
  • Herein, we describe the cytologic findings and histology of four aspiration cytology specimens of thymic adenocarcinoma. (jpatholtm.org)
  • Conclusions: This new classification strategy is based on a multidisciplinary approach to diagnosis of lung adenocarcinoma that incorporates clinical, molecular, radiologic, and surgical issues, but it is primarily based on histology. (elsevier.com)
  • Invasive lung adenocarcinomas are classified by their predominant tumor pattern on histology (microscopy). (icnet.uk)
  • METHODS: 110 primary lung adenocarcinoma cases were analyzed for clinicopathologic parameters, including overall survival, stage, histology, napsin A and TTF-1 expression, EGFR mutation, and ALK rearrangement. (yonsei.ac.kr)
  • Supportive criteria include enteric-type histology, absence of urothelial dysplasia, cystitis cystica or cystitis glandularis transitioning to the tumor, and absence of primary adenocarcinoma of another organ [ 6 ]. (biomedcentral.com)
  • In the gastrointestinal (GI) tract, infections with pathogenic microbes, such as with Helicobacter pylori , lead to chronic inflammation (gastritis) and cancer (gastric adenocarcinoma) in humans and in mouse models [ 4 ]. (plos.org)
  • 9 In recent years the incidence of gastric cardia adenocarcinoma (GCA) has risen rapidly, whereas that of distal gastric adenocarcinoma has steadily decreased. (healthdocbox.com)
  • These trends suggest that GCA is different in nature from distal gastric adenocarcinoma. (healthdocbox.com)
  • There are a number of reports on lymph node micrometastasis in distal gastric adenocarcinoma 10,11 but little has been published on such micrometastases in GCA. (healthdocbox.com)
  • Gastric adenocarcinoma is a known complication of partial gastrectomy. (biomedcentral.com)
  • Jaundice from gastric adenocarcinoma usually occurs in the setting of hepatic nodal or parenchymal metastasis. (biomedcentral.com)
  • This case demonstrates an unusual level of biliary obstruction from gastric adenocarcinoma. (biomedcentral.com)
  • An 84-year-old Caucasian man was diagnosed as having a new gastric adenocarcinoma at the level of the gastroenteric anastomosis of a prior Billroth II gastrectomy after presenting with painless jaundice. (biomedcentral.com)
  • Endoscopic duodenal stenting is a novel method of managing obstructive jaundice in gastric adenocarcinoma. (biomedcentral.com)
  • Here we present an unusual case of an 84-year-old man diagnosed as having gastric adenocarcinoma following presentation with obstructive jaundice in the setting of a previous Billroth II gastrectomy for peptic ulcer disease. (biomedcentral.com)
  • 2003) "Helicobacter pylori genotyping in gastric adenocarcinoma and MALT lymphoma by multiplex PCR analysis of paraffin wax embedded tissues" Mol Pathol Feb. (patentgenius.com)
  • Poorly differentiated gastric adenocarcinoma with lymphoplasmacytic stroma may be positive for EBV-LMP or EBER. (zeta-corp.com)
  • Adenocarcinoma of the lung may be classified according to IASLC/ATS/ERS into pre-invasive lesions, atypical adenomatous hyperplasia, adenocarcinoma in situ, minimally invasive adenocarcinoma, invasive adenocarcinoma, and variants of invasive adenocarcinoma. (wikidoc.org)
  • adenocarcinoma in situ, low-grade adenocarcinomas, and minimally invasive adenocarcinoma are commonly associated with PET false-negative results. (radiopaedia.org)
  • For resection specimens, new concepts are introduced such as adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) for small solitary adenocarcinomas with either pure lepidic growth (AIS) or predominant lepidic growth with ≤5 mm invasion (MIA) to define patients who, if they undergo complete resection, will have 100% or near 100% disease-specific survival, respectively. (elsevier.com)
  • IASLC) American Thoracic Society (ATS) and the European Respiratory Society (ERS) lung cancer classification , such as adenocarcinoma in situ (AIS), which has pure ' lepidic ' growth (see Section 4 ) and minimally invasive adenocarcinoma (MIA) for small solitary adenocarcinomas with predominant lepidic growth and with ≤ 5 mm invasion (MIA). (icnet.uk)
  • Furthermore, these adenocarcinomas are classified by the stage of development from atypia to in-situ to invasive adenocarcinoma of the lung. (icnet.uk)
  • Primary pulmonary enteric adenocarcinoma (PEAC) is an extremely rare variant of invasive lung cancer. (biomedcentral.com)
  • We compared the clinicopathological, radiographic, and oncogenic characteristics of PEAC and primary pulmonary invasive adenocarcinoma (IAC).A total of 28 PEAC patients and 92 IAC patients were compared. (cdc.gov)
  • EGFR = epidermal growth factor receptor, IAC = invasive adenocarcinoma, KRAS = Kristen rat sarcoma viral oncogene homolog, PEAC = pulmonary enteric adenocarcinoma. (cdc.gov)
  • In 2011, the new lung adenocarcinoma classification was published and supported by the International Association for the Study of Lung Cancer (IASLC), the American Thoracic Society (ATS), and the European Respiratory Society (ERS): PEAC was first reconized as a rare variant of LAC. (edoriumjournals.com)
  • Invasive adenocarcinomas are classified by their predominant histological pattern . (icnet.uk)
  • Thymic adenocarcinoma is extremely rare. (jpatholtm.org)
  • The cytologic features were correlated with the histologic features in each case of enteric type thymic adenocarcinoma. (jpatholtm.org)
  • However, the cytologic features of thymic adenocarcinoma have not yet been reported. (jpatholtm.org)
  • In this study, we investigated the characteristics of thymic adenocarcinoma in aspiration cytology based on four specimens from three patients. (jpatholtm.org)
  • We analyzed the cytologic features and histologic characteristics as well as the differential diagnosis of thymic adenocarcinoma. (jpatholtm.org)
  • The clinicopathologic characteristics of four thymic adenocarcinoma specimens are summarized in Table 1 . (jpatholtm.org)
  • Thymic adenocarcinoma associated with thymic cyst: a case report and review of literature. (semanticscholar.org)
  • Difficulties in diagnosis and treatment of thymic adenocarcinoma producing beta-human chorionic gonadotropin in anterior mediastinum. (semanticscholar.org)
  • Primary thymic adenocarcinoma coexisting with type AB thymoma: a rare case with long-term survival. (semanticscholar.org)
  • Lung adenocarcinoma (LAC) has a complex variety of different hystopathologic subtypes including acinar, papillar, micropapillar, solid and lepidic patterns. (edoriumjournals.com)
  • in 5 patients (0.7% of all those studied), bronchogenic cysts were associated with malignancies: 1 squamous cell, 1 adenocarcinoma, 2 bronchioalveolar carcinomas and 1 large-cell anaplastic carcinoma. (archbronconeumol.org)
  • Multistep tumorigenesis explains pathogenesis of centrally located squamous cell carcinoma of the lung very well but fails to explain pathogenesis of large cell lung carcinomas , lung adenocarcinomas , and small cell lung cancer . (wikidoc.org)
  • Primary adenocarcinoma of the bladder overall is rare, and accounts for only 1% of bladder carcinomas. (auanet.org)
  • Small cell lung carcinomas (SCLCs) account for 20% of all lung cancers, and the remaining 80% consists of non-small cell lung carcinomas (NSCLCs) which, in turn, is further subclassified into 40% adenocarcinoma (AC), 40% squamous cell carcinoma (SCC) and 20% large cell carcinoma. (biomedcentral.com)
  • Thymic enteric type adenocarcinoma: A case report with cytological features. (semanticscholar.org)
  • Chemotherapy appropriate for enteric type adenocarcinoma can induce objective responses but meaningful improvement in survival is not yet demonstrated. (nih.gov)
  • Enteric type adenocarcinoma of the upper tract urothelium associated with ectopic ureter and renal dysplasia: an oncological rationale for complete extirpation of this aberrant developmental anomaly. (healthtap.com)
  • To the best of our knowledge, this is the first case of enteric adenocarcinoma arising from an intrapulmonary bronchogenic cyst. (archbronconeumol.org)
  • 3-8 In these cases, histological findings were bronchioalveolar carcinoma, adenocarcinoma, squamous cell carcinoma and large cell carcinoma. (archbronconeumol.org)
  • Adenocarcinoma of the lung may be classified according to WHO into mixed, acinar , papillary , bronchioloalveolar carcinoma , and subtypes. (wikidoc.org)
  • The solid variant of adenocarcinoma is less 'well-differentiated' and is histologically indistinguishable from 'large cell undifferentiated' carcinoma, except for the presence of intracellular mucin . (icnet.uk)
  • The patient was a young woman who suffered from locally advanced urachal carcinoma treated with en-bloc cystectomy, hysterectomy with bilateral adnexectomy, partial resection of the sigmoid colon, and partial resection of the rectus abdominis muscle with the fascia, skin, and umbilicus. (biomedcentral.com)
  • Bladder adenocarcinoma, enteric type, growing as polypoid lesion of rheumatic disease. (meownowfl.org)
  • YUHSpace: Napsin A is an independent prognostic factor in surgically resected adenocarcinoma of the lung. (yonsei.ac.kr)
  • Medical records and pathologic slides were reviewed for a total of 107 surgically resected lung adenocarcinomas. (allenpress.com)
  • Environmental enteric dysfunction (EED), a pervasive chronic subclinical inflammatory condition among children that develops when complementary foods are introduced, places them at high risk of stunting, malabsorption, and poor oral vaccine efficacy. (biomedcentral.com)
  • Should always include metastasis or extension from an intestinal adenocarcinoma, before making the diagnosis. (auanet.org)
  • The histopathological ( microscopic ) diagnosis of adenocarcinoma of the lung requires observation of tumor gland formation or mucin secretion within tumor cell cytoplasm. (icnet.uk)
  • Primary adenocarcinoma of the lung--histological subtypes and outcome after surgery, using the IASLC/ATS/ERS classification of lung adenocarcinoma. (semanticscholar.org)
  • The upcoming International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification of lung adenocarcinoma is relevant in that it shows a phenotype-genotype correlation. (allenpress.com)
  • 7 - 11 For these reasons the International Association for the Study of Lung Cancer, the American Thoracic Society, and the European Respiratory Society have been developing a new classification of lung adenocarcinoma during the past few years. (allenpress.com)
  • Liver metastasis of a pulmonary acinous adenocarcinoma. (humpath.com)
  • Ret signaling is critical for formation of the enteric nervous system (ENS) because Ret activation promotes ENS precursor survival, proliferation, and migration and provides trophic support for mature enteric neurons. (jneurosci.org)
  • These temporal differences in the timing of the last mitosis for precursors that give rise to specific neuron classes suggest that the timing and intensity of trophic factor expression may critically determine the ratio of neuron subtypes within the ENS by altering the proliferation of precursors determined to become specific types of enteric neurons. (jneurosci.org)
  • Microejection of toxin B had no effect on the V m of enteric neurons. (physiology.org)
  • Evidence of a direct excitatory effect of IL-1β on V m was detected in a minority of enteric neurons. (physiology.org)
  • These data suggest that infections with enteric pathogens enhance T R -cell potency and protect against epithelial cancers later in life, potentially explaining paradoxical increases in cancer risk in developed countries having more stringent hygiene practices. (aacrjournals.org)
  • Although some of these alterations can be explained by the effect of pathogens on target cells such as epithelial or immune cells, recent experimental evidence suggests that the enteric nervous system (ENS) plays a key role in the pathogenesis of infectious diseases and their symptoms. (physiology.org)
  • 7 Although the detailed revision and diagnostic criteria of the new lung adenocarcinoma classification are not yet officially approved, it is necessary to investigate its relevance correlated with EGFR mutations because EGFR mutation is established as one of the most important predictive markers for EGFR tyrosine kinase inhibitors in NSCLC. (allenpress.com)
  • Enteric duplication cysts (EDCs) are rare congenital malformations formed during the embryonic development of the digestive tract. (springer.com)
  • Chen MK, Gross E, Lobe TE: Perinatal management of enteric duplication cysts of the tongue. (springermedizin.de)
  • Adenocarcinoma of the lung is the most common histologic type of lung cancer . (radiopaedia.org)
  • To evaluate the correlation between epidermal growth factor receptor mutations and histologic subtypes of lung adenocarcinomas according to the upcoming new classification of lung adenocarcinomas. (allenpress.com)
  • 1 , 2 Among histologic types of NSCLCs, rates of adenocarcinoma are increasing in most countries. (allenpress.com)
  • To the best of our knowledge, this is the first case of bronchogenic cysts associated with an enteric adenocarcinoma and, in this case, malignant degeneration was the reason for surgical resection. (archbronconeumol.org)
  • To perform these activities, there are many enteric neuron subtypes with distinct transmitter phenotypes, neurite extension patterns, electrophysiology, and function ( Furness, 2000 ). (jneurosci.org)
  • Extramural perineural invasion in pT3 and pT4 rectal adenocarcinoma as prognostic factor after preoperative chemoradiotherapy. (amedeo.com)
  • Computed tomography and endoscopy revealed the biliary-enteric fistula to be caused by metastatic colon adenocarcinoma invading the biliary tree. (gi.org)
  • A 76-year-old woman with stage 4 invasive colon adenocarcinoma, status post chemotherapy and right hemicolectomy with metastatic spread to the liver and lung, presented with abdominal pain, melena, and coffee-ground emesis. (gi.org)
  • Clinicopathological, radiographic, and oncogenic features of primary pulmonary enteric adenocarcinoma in comparison with invasive adenocarcinoma in resection specimens. (cdc.gov)
  • Treated by en bloc resection of bladder, urachal remnant, and umbilicus. (auanet.org)
  • However, long-term survival following radical resection occurs in a significant fraction of patients (16 of 35 in our series), supporting an attempt at margin-negative, en bloc resection if at all possible. (nih.gov)
  • Pulmonary enteric adenocarcinoma: a study of the clinicopathologic and molecular status of nine cases. (radiopaedia.org)
  • There is still no effective model in vivo , however, that thoroughly investigates the effect and molecular mechanism of RBM5 on lung adenocarcinoma. (biomedcentral.com)
  • 3 Lung adenocarcinomas are well known for their clinical, radiologic, pathologic, and molecular heterogeneity. (allenpress.com)
  • Not only that, but since epidermal growth factor receptor ( EGFR ) mutations were discovered in 2004, 5 , 6 numerous studies have been performed with the main focus on molecular pathogenesis and predictive factors of lung adenocarcinomas associated with targeted therapy. (allenpress.com)
  • In this proposal, the effect of synthetic GEs on EGCs isolated from a cohort of pediatric CD patients and controls will be evaluated in their cellular uptake, intracellular traffic, influence on molecular and paracellular signaling toward human duodenal adenocarcinoma or lymphoma established cells, to finally evaluate the GEs induced effects on tumorigenicy (viability, proliferation and cell death modulation). (celiachia.it)
  • KRAS and PIK3CA mutations in colorectal adenocarcinomas correlate with aggressive histological features and behavior. (amedeo.com)
  • It has been reported that the incidence of some neoplastic disorders, particularly malignant lymphoma and small intestinal adenocarcinoma, are increased in celiac disease (CD). (celiachia.it)