The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.
These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.
Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.
A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular Ig-like domains which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.
A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.
A CXC chemokine that is induced by GAMMA-INTERFERON and is chemotactic for MONOCYTES and T-LYMPHOCYTES. It has specificity for the CXCR3 RECEPTOR.
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.
Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes one of the fatty acid moieties.
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
A family of hoofed MAMMALS consisting of HORSES, donkeys, and zebras. Members of this family are strict herbivores and can be classified as either browsers or grazers depending on how they feed.
The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and SALIVARY GLANDS, and convey afferent information for TASTE from the anterior two-thirds of the TONGUE and for TOUCH from the EXTERNAL EAR.
Neurons which activate MUSCLE CELLS.
An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Camellia sinensis L. (formerly Thea sinensis) is an evergreen Asiatic shrub of the THEACEAE family. The infusion of leaves of this plant is used as Oriental TEA which contains CAFFEINE; THEOPHYLLINE; and epigallocatechin gallate.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.
A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
Hydrochloric acid present in GASTRIC JUICE.

VEGF is required for growth and survival in neonatal mice. (1/2914)

We employed two independent approaches to inactivate the angiogenic protein VEGF in newborn mice: inducible, Cre-loxP- mediated gene targeting, or administration of mFlt(1-3)-IgG, a soluble VEGF receptor chimeric protein. Partial inhibition of VEGF achieved by inducible gene targeting resulted in increased mortality, stunted body growth and impaired organ development, most notably of the liver. Administration of mFlt(1-3)-IgG, which achieves a higher degree of VEGF inhibition, resulted in nearly complete growth arrest and lethality. Ultrastructural analysis documented alterations in endothelial and other cell types. Histological and biochemical changes consistent with liver and renal failure were observed. Endothelial cells isolated from the liver of mFlt(1-3)-IgG-treated neonates demonstrated an increased apoptotic index, indicating that VEGF is required not only for proliferation but also for survival of endothelial cells. However, such treatment resulted in less significant alterations as the animal matured, and the dependence on VEGF was eventually lost some time after the fourth postnatal week. Administration of mFlt(1-3)-IgG to juvenile mice failed to induce apoptosis in liver endothelial cells. Thus, VEGF is essential for growth and survival in early postnatal life. However, in the fully developed animal, VEGF is likely to be involved primarily in active angiogenesis processes such as corpus luteum development.  (+info)

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. (2/2914)

Interaction between integrin alphavbeta3 and extracellular matrix is crucial for endothelial cells sprouting from capillaries and for angiogenesis. Furthermore, integrin-mediated outside-in signals co-operate with growth factor receptors to promote cell proliferation and motility. To determine a potential regulation of angiogenic inducer receptors by the integrin system, we investigated the interaction between alphavbeta3 integrin and tyrosine kinase vascular endothelial growth factor receptor-2 (VEGFR-2) in human endothelial cells. We report that tyrosine-phosphorylated VEGFR-2 co-immunoprecipitated with beta3 integrin subunit, but not with beta1 or beta5, from cells stimulated with VEGF-A165. VEGFR-2 phosphorylation and mitogenicity induced by VEGF-A165 were enhanced in cells plated on the alphavbeta3 ligand, vitronectin, compared with cells plated on the alpha5beta1 ligand, fibronectin or the alpha2beta1 ligand, collagen. BV4 anti-beta3 integrin mAb, which does not interfere with endothelial cell adhesion to vitronectin, reduced (i) the tyrosine phosphorylation of VEGFR-2; (ii) the activation of downstream transductor phosphoinositide 3-OH kinase; and (iii) biological effects triggered by VEGF-A165. These results indicate a new role for alphavbeta3 integrin in the activation of an in vitro angiogenic program in endothelial cells. Besides being the most important survival system for nascent vessels by regulating cell adhesion to matrix, alphavbeta3 integrin participates in the full activation of VEGFR-2 triggered by VEGF-A, which is an important angiogenic inducer in tumors, inflammation and tissue regeneration.  (+info)

Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression. (3/2914)

Vascular endothelial growth factor (VEGF) is a potent angiogenic inducer that stimulates the expression of tissue factor (TF), the major cellular initiator of blood coagulation. Here we show that signaling triggered by VEGF induced DNA-binding and transcriptional activities of nuclear factor of activated T cells (NFAT) and AP-1 in human umbilical vein endothelial cells (HUVECs). VEGF also induced TF mRNA expression and gene promoter activation by a cyclosporin A (CsA)-sensitive mechanism. As in lymphoid cells, NFAT was dephosphorylated and translocated to the nucleus upon activation of HUVECs, and these processes were blocked by CsA. NFAT was involved in the VEGF-mediated TF promoter activation as evidenced by cotransfection experiments with a dominant negative version of NFAT and site-directed mutagenesis of a newly identified NFAT site within the TF promoter that overlaps with a previously identified kappaB-like site. Strikingly, this site bound exclusively NFAT not only from nuclear extracts of HUVECs activated by VEGF, a stimulus that failed to induce NF-kappaB-binding activity, but also from extracts of cells activated with phorbol esters and calcium ionophore, a combination of stimuli that triggered the simultaneous activation of NFAT and NF-kappaB. These results implicate NFAT in the regulation of endothelial genes by physiological means and shed light on the mechanisms that switch on the gene expression program induced by VEGF and those regulating TF gene expression.  (+info)

Expression of vascular endothelial growth factor in human oral squamous cell carcinoma: its association with tumour progression and p53 gene status. (4/2914)

AIMS: To correlate vascular endothelial growth factor (VEGF) expression in oral squamous cell carcinoma with the clinicopathological characteristics and prognosis; and to assess whether p53 gene status is associated with VEGF expression in human cancers. METHODS: Tumour specimens from 45 patients with oral squamous cell carcinomas were examined. Expression of VEGF was determined using an immunohistochemical method, and a tumour was considered positive when more than 5% of the neoplastic cells showed VEGF immunoreactivity. The p53 gene status was screened using a polymerase chain reaction--single strand conformation polymorphism analysis. RESULTS: VEGF positive staining was detected in 19 (42.2%) of the 45 cases. VEGF immunoreactivity did not correlate with the histological degree of tumour differentiation, clinical stages, or lymph node metastasis. The patients with VEGF positive tumours had a significantly worse prognosis than those with VEGF negative tumours. The five year overall survival rate of the VEGF negative patients was 76.5%, as compared with 48.8% for the VEGF positive patients. No significant association between VEGF expression and the p53 gene status of the tumours was found. CONCLUSIONS: VEGF is a good prognostic indicator of the survival of patients with oral squamous cell carcinoma. The p53 gene status does not seem to be associated with VEGF expression in these cancers.  (+info)

Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine kinase is mediated by nitric oxide in rat renal mesangial cells. (5/2914)

Under conditions associated with local and systemic inflammation, mesangial cells and invading immune cells are likely to be responsible for the release of large amounts of nitric oxide (NO) in the glomerulus. To further define the mechanisms of NO action in the glomerulus, we attempted to identify genes which are regulated by NO in rat glomerular mesangial cells. We identified vascular endothelial growth factor (VEGF) and its receptor fms-like tyrosine kinase (FLT-1) to be under the regulatory control of exogenously applied NO in these cells. Using S-nitroso-glutathione (GSNO) as an NO-donating agent, VEGF expression was strongly induced, whereas expression of its FLT-1 receptor simultaneously decreased. Expressional regulation of VEGF and FLT-1 mRNA was transient and occurred rapidly within 1-3 h after GSNO treatment. Expression of a second VEGF-specific receptor, fetal liver kinase-1 (FLK-1/KDR), could not be detected. The inflammatory cytokine interleukin-1beta mediated a moderate increase in VEGF expression after 24 h and had no influence on FLT-1 expression. In contrast, platelet-derived growth factor-BB and basic fibroblast growth factor had no effect on VEGF expression, but strongly induced FLT-1 mRNA levels. Obviously, there is a differential regulation of VEGF and its receptor FLT-1 by NO, cytokines and growth factors in rat mesangial cells.  (+info)

Vascular endothelial growth factor (VEGF) receptor II-derived peptides inhibit VEGF. (6/2914)

Vascular endothelial growth factor (VEGF) directly stimulates endothelial cell proliferation and migration via tyrosine kinase receptors of the split kinase domain family. It mediates vascular growth and angiogenesis in the embryo but also in the adult in a variety of physiological and pathological conditions. The potential binding site of VEGF with its receptor was identified using cellulose-bound overlapping peptides of the extracytosolic part of the human vascular endothelial growth factor receptor II (VEGFR II). Thus, a peptide originating from the third globular domain of the VEGFR II comprising residues 247RTELNVGIDFNWEYP261 was revealed as contiguous sequence stretch, which bound 125I-VEGF165. A systematic replacement with L-amino acids within the peptide representing the putative VEGF-binding site on VEGFR II indicates Asp255 as the hydrophilic key residue for binding. The dimerized peptide (RTELNVGIDFNWEYPAS)2K inhibits VEGF165 binding with an IC50 of 0.5 microM on extracellular VEGFR II fragments and 30 microM on human umbilical vein cells. VEGF165-stimulated autophosphorylation of VEGFR II as well as proliferation and migration of microvascular endothelial cells was inhibited by the monomeric peptide RTELNVGIDFNWEYPASK at a half-maximal concentration of 3-10, 0.1, and 0.1 microM, respectively. We conclude that transduction of the VEGF165 signal can be interrupted with a peptide derived from the third Ig-like domain of VEGFR II by blockade of VEGF165 binding to its receptor.  (+info)

Expression of thrombospondin-1 in ischemia-induced retinal neovascularization. (7/2914)

Thrombospondin-1 is an extracellular matrix protein that inhibits endothelial cell proliferation, migration, and angiogenesis. This study was performed to investigate the role of thrombospondin-1 in ischemic retinal neovascularization. In a murine model of retinal neovascularization, thrombospondin-1 mRNA was increased from postnatal day 13 (P13), with a threefold peak response observed on P15, corresponding to the time of development of retinal neovascularization. Prominent expression of thrombospondin-1 was observed in neovascular cells, specifically, cells adjacent to the area of nonperfusion. It has been suggested that vascular endothelial growth factor (VEGF) plays a major role in ischemia-induced retinal neovascularization of this model, so we studied the effects of VEGF on thrombospondin-1 expression. In bovine retinal microcapillary endothelial cells, VEGF induced a biphasic response of thrombospondin-1 expression; VEGF decreased thrombospondin-1 mRNA 0.41-fold after 4 hours, whereas it increased, with a threefold peak response, after 24 hours. VEGF-induced endothelial cell proliferation was completely inhibited by exogenous thrombospondin-1 and increased by 37.5% with anti-thrombospondin-1 antibody. The present findings suggest that, in the ischemic retina, retinal neovascular cells increase thrombospondin-1 expression, and VEGF may stimulate endogenous thrombospondin-1 induction, which inhibits endothelial cell growth. VEGF-mediated thrombospondin-1 induction in ischemia-induced angiogenesis may be a negative feedback mechanism.  (+info)

Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF. (8/2914)

Diabetes is a major risk factor for coronary and peripheral artery diseases. Although diabetic patients often present with advanced forms of these diseases, it is not known whether the compensatory mechanisms to vascular ischemia are affected in this condition. Accordingly, we sought to determine whether diabetes could: 1) impair the development of new collateral vessel formation in response to tissue ischemia and 2) inhibit cytokine-induced therapeutic neovascularization. Hindlimb ischemia was created by femoral artery ligation in nonobese diabetic mice (NOD mice, n = 20) and in control C57 mice (n = 20). Hindlimb perfusion was evaluated by serial laser Doppler studies after the surgery. In NOD mice, measurement of the Doppler flow ratio between the ischemic and the normal limb indicated that restoration of perfusion in the ischemic hindlimb was significantly impaired. At day 14 after surgery, Doppler flow ratio in the NOD mice was 0.49+/-0.04 versus 0.73+/-0.06 for the C57 mice (P< or =0.005). This impairment in blood flow recovery persisted throughout the duration of the study with Doppler flow ratio values at day 35 of 0.50+/-0.05 versus 0.90+/-0.07 in the NOD and C57 mice, respectively (P< or =0.001). CD31 immunostaining confirmed the laser Doppler data by showing a significant reduction in capillary density in the NOD mice at 35 days after surgery (302+/-4 capillaries/mm2 versus 782+/-78 in C57 mice (P< or =0.005). The reduction in neovascularization in the NOD mice was the result of a lower level of vascular endothelial growth factor (VEGF) in the ischemic tissues, as assessed by Northern blot, Western blot and immunohistochemistry. The central role of VEGF was confirmed by showing that normal levels of neovascularization (compared with C57) could be achieved in NOD mice that had been supplemented for this growth factor via intramuscular injection of an adenoviral vector encoding for VEGF. We conclude that 1) diabetes impairs endogenous neovascularization of ischemic tissues; 2) the impairment in new blood vessel formation results from reduced expression of VEGF; and 3) cytokine supplementation achieved by intramuscular adeno-VEGF gene transfer restores neovascularization in a mouse model of diabetes.  (+info)

Thymidine phosphorylase/platelet-derived endothelial cell growth factor (TPase/PD-ECGF) is a catabolic enzyme that has been shown to be chemotactic for endothelial cells in vitro and angiogenic in vivo. TPase/PD-ECGF expression is increased in a variety of tumors. In the skin, TPase is active in normal keratinocytes in vitro and in vivo. Our objective was to study the expression and localization of TPase/PD-ECGF by immunohistochemical analysis in normal skin and cutaneous tumors and to correlate this information with enzymatic activity of TPase. TPase/PD-ECGF expression was observed in keratinocytes with intense staining of the infundibulum of hair follicles but no staining of hair bulbs. Expression localized primarily to the nucleus of keratinocytes in the basal layer but was more intense and cytoplasrmic in suprabasal keratinocytes. Increased expression of TPase/PD-ECGF in differentiated cells was confirmed by in vitro studies of TPase activity. In cutaneous tumors, there was positive staining ...
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature (2000) 5.86 EAACI/GA(2)LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria. Allergy (2009) 4.10 EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria. Allergy (2009) 3.86 CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. Cell (1992) 3.70 The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update. Allergy (2014) 3.10 A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. J Invest Dermatol (1999) 2.92 Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206. Mol Biol Cell (1998) 2.24 Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 ...
161110PRTHomo sapiens 1Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val1 5 10 15Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser 20 25 30Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 35 40 45Val Leu Ile Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser 50 55 60Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile65 70 75Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 80 85 90Tyr Ser Thr Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 95 100 105Ile Lys Arg Thr Val 1102110PRTHomo sapiens 2Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val1 5 10 15Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Glu Gln Leu Ser 20 25 30Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 35 40 45Val Leu Ile Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser 50 55 60Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile65 70 75Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 80 85 90Tyr Ser Thr Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu ...
Table of Contents. Table of Contents 2. List of Tables 5. List of Figures 5. Introduction 6. Global Markets Direct Report Coverage 6. Placenta Growth Factor (Vascular Endothelial Growth Factor Related Protein or PGF) Overview 7. Therapeutics Development 8. Placenta Growth Factor (Vascular Endothelial Growth Factor Related Protein or PGF)-Products under Development by Stage of Development 8. Placenta Growth Factor (Vascular Endothelial Growth Factor Related Protein or PGF)-Products under Development by Therapy Area 9. Placenta Growth Factor (Vascular Endothelial Growth Factor Related Protein or PGF)-Products under Development by Indication 10. Placenta Growth Factor (Vascular Endothelial Growth Factor Related Protein or PGF)-Pipeline Products Glance 11. Late Stage Products 11. Early Stage Products 12. Placenta Growth Factor (Vascular Endothelial Growth Factor Related Protein or PGF)-Products under Development by Companies 13. Placenta Growth Factor (Vascular Endothelial Growth Factor Related ...
Prognostic significance of plasma vascular endothelial growth factor levels in patients with hormone-refractory prostate cancer treated on Cancer and Leukemia Group B 9480.
Background: The development of biomarkers predictive of response to immune checkpoint inhibitor (ICI) therapies in advanced melanoma is an area of great interest in oncology. Our study evaluated the potential role of serum vascular endothelial growth factor (VEGF) as a predictive biomarker of clinical benefit and response to treatment with ICIs.Methods: Pre-treatment peripheral blood samples were obtained from advanced melanoma patients undergoing ICI therapy as monotherapy or in combination at two tertiary care hospitals in Western Australia. Serum VEGF levels were correlated with response to therapy and survival outcomes.Results: Serum VEGF samples were collected from a total of 130 patients treated with ICI therapy (pembrolizumab 73, ipilimumab 15, and ipilimumab/nivolumab combination 42). Median serum VEGF level was significantly higher in the non-responders (82.15 pg/mL) vs. responders (60.40 pg/mL) in the ipilimumab monotherapy cohort (P Conclusions: The results of our study confirm previous
TY - JOUR. T1 - Capsaicin regulates vascular endothelial cell growth factor expression by modulation of hypoxia inducing factor-1α in human malignant melanoma cells. AU - Patel, Prabhudas S.. AU - Yang, Shillin. AU - Li, Aihua. AU - Varney, Michelle L.. AU - Singh, Rakesh K. PY - 2002/10/9. Y1 - 2002/10/9. N2 - Purpose: Capsaicin (8-Methyl-N-Vanillyl-6-nonenamide), a known natural dietary chemopreventive agent, inhibits malignant melanoma cell proliferation. In the present study, we examined the effect of capsaicin on constitutive and induced vascular endothelial cell growth factor (VEGF) expression in malignant melanoma cells. Results: Capsaicin treatment resulted in enhanced VEGF protein secretion in malignant melanoma cells independent of IL-1β and TNF-α. The observed up-regulation of VEGF production by capsaicin was concentration- and duration-dependent and was inversely associated with inhibition of melanoma cell proliferation. We observed an increase in hypoxia-inducible factor ...
Can serial monitoring of serum Vascular Endothelial Growth Factor (VEGF), Nitric Oxide (NO), and Angiotensin II (ANGII) levels have predictive role during Bevacizumab treatment? - Add Comment #889945
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Regulation by hypoxia may underlie the expression of vascular endothelial growth factor in bladder cancer. We have compared the distribution of vascular endothelial growth factor mRNA with a hypoxia marker, carbonic anhydrase 9 (CA IX). vascular endothelial growth factor mRNA was analysed by in situ hybridisation and CA IX by immunochemistry in 22 cases of bladder cancer. The relationship of microvessels to the distribution of CA IX was determined. In a separate series of 49 superficial tumours, CA IX immunostaining was compared with clinico-pathological outcome. In superficial and invasive disease there was overlap in the expression of vascular endothelial growth factor and CA IX, CA IX being more widespread. Both were expressed predominantly on the luminal surface, and surrounding areas of necrosis (invasive tumours). Expression of both factors was greater in superficial disease. Expression was absent within approximately 80 microm of microvessels. Unlike vascular endothelial growth factor, CA IX did
Title:Targeting Vascular Endothelial Growth Factor in Neuroblastoma. VOLUME: 2 ISSUE: 1. Author(s):Danielle Hsu, Jason M. Shohet and Eugene S. Kim. Affiliation:Division of Pediatric Surgery, Texas Childrens Hospital, CCC Building, Suite 1210, 6701 Fannin St, Houston, TX 77030, USA.. Keywords:Vascular endothelial growth factor, angiogenesis, clinical trials, neuroblastoma.. Abstract:Angiogenesis is critical to tumor growth and metastasis and is dependent on growth factors, such as vascular endothelial growth factor (VEGF). The most characterized angiogenic factor, VEGF is an endothelial cell mitogen and permeability factor that has been found to be overexpressed in almost all human cancers. In a number of tumor model systems, antagonism of the VEGF pathway results in inhibition of angiogenesis and tumor growth. Specifically, VEGF inhibition has been shown to suppress tumor growth, decrease microvasculature, and induce apoptosis of endothelial cells. This close relationship between hypoxia, ...
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as tumor angiogenesis factor and vascular permeability factor. Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced ...
Angiogenesis, the growth of blood vessel from the existing vasculature, depends on the expression of various growth factors but Vascular Endothelial Growth factor (VEGF) ranks as the key inducer and the central mediator that promotes vascular permeability.
Vascular permeability factor (VPF) is a 40-kilodalton disulfide-linked dimeric glycoprotein that is active in increasing blood vessel permeability, endothelial cell growth, and angiogenesis. These properties suggest that the expression of VPF by tumor cells could contribute to the increased neovascularization and vessel permeability that are associated with tumor vasculature. The cDNA sequence of VPF from human U937 cells was shown to code for a 189-amino acid polypeptide that is similar in structure to the B chain of platelet-derived growth factor (PDGF-B) and other PDGF-B-related proteins. The overall identity with PDGF-B is 18%. However, all eight of the cysteines in PDGF-B were found to be conserved in human VPF, an indication that the folding of the two proteins is probably similar. Clusters of basic amino acids in the COOH-terminal halves of human VPF and PDGF-B are also prevalent. Thus, VPF appears to be related to the PDGF/v-sis family of proteins.
Placental villous vascular endothelial growth factor expression and vascularization after estrogen suppression during the last two-thirds of baboon pregnancy Article ...
TY - CHAP. T1 - The role of vascular endothelial growth factor in major depression. AU - Lee, Bun Hee. AU - Kim, Yong Ku. PY - 2013. Y1 - 2013. N2 - Vascular endothelial growth factor (VEGF) is a potent angiogenic factor under physiological and pathological conditions, including tumor angiogenesis. Recently, the effects of VEGF on neurons have been reported. VEGF and its high-affinity tyrosine kinase receptors, VEGFR1 and VEGFR2, are expressed in specific brain regions. In addition, VEGF has been suggested to play an important role in the cross-talk between endothelial cells and neuronal progenitors in the hippocampus, indicating that VEGF may stimulate hippocampal neurogenesis. Neurotrophic factors and neurogenesis are associated with the development of major depression and play essential roles in mediating the therapeutic response to antidepressants. Several animal studies have shown that chronic stress decreased the expression of VEGF and VEGFR2 in granular cells. There is also evidence ...
Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a potent microvascular permeability-enhancing mediator as well as a selective mitogen for vascular endothelium. In this study, in situ hybridization and immunohistochemistry co-localized VPF mRNA and prot …
TY - JOUR. T1 - Vascular endothelial growth factor regulates excitatory synaptic transmission in hippocampal neurons. AU - Huang, Yu Fei. AU - Yang, Chih Hao. AU - Chiou, Chiuan Shiou. AU - Huang, Chiung Chun. AU - Hsu, Kuei Sen. PY - 2010. Y1 - 2010. N2 - Vascular endothelial growth factor (VEGF), in addition to its essential role in the processes of vascularization and angiogenesis, exerts direct effects on neural cells in the central nervous system. There is abundant evidence indicating that VEGF protects neurons against cell death induced by a variety of insults, including hypoxia/ischemia and seizures. Recent work has demonstrated the expression of VEGF and its receptors in neurons and has revealed that VEGF can act as a neurotrophic factor to regulate neurogenesis and mediate the effects of enriched environment and antidepressants on hippocampal plasticity. Current studies from our laboratory and those of others have found that VEGF can activate divergent signaling components to regulate ...
Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene. This gene is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. VEGF-A shows prominent activity with vascular endothelial cells, primarily through its interactions with the VEGFR1 and -R2 receptors found in prominently on the endothelial cell membrane. Although, it does have effects on a number of other cell types (e.g., stimulation monocyte/macrophage migration, ...
TY - JOUR. T1 - Vascular endothelial growth factor as a biomarker for the early detection of cancer using a whole cell-based biosensor. AU - May, Kimberly M L. AU - Vogt, Adam. AU - Bachas, Leonidas G. AU - Anderson, Kimberly W.. PY - 2005/6. Y1 - 2005/6. N2 - Vascular endothelial growth factor (VEGF) is a cytokine and endothelial cell (EC) mitogen that has been studied for its role in angiogenesis of malignant tumors. Elevated quantities of VEGF in the serum and plasma of patients have been correlated with the presence of cancer and metastasis. Since VEGF induces hyperpermeability of EC monolayers, this protein can be detected in vitro with a whole cell-based biosensor. This biosensor consists of a confluent monolayer of human umbilical vein endothelial cells (HUVECs) attached to a cellulose triacetate (CTA) membrane of an ion-selective electrode (ISE). Previous studies regarding this biosensor have shown that when the biosensor was exposed to a model toxin, such as histamine, the response of ...
Vascular Endothelial Growth Factor from mouse (mVEGF ); VEGF, E. coli, powder, cell culture; Suitable for mammalian cell culture; Vascular endothelial growth factor (VEGF) supports development of new blood vessels during embryonic development and after vascular injury; Vascular endothelial gr
TY - JOUR. T1 - Inverse correlation between vascular endothelial growth factor back-filtration and capillary filtration pressures. AU - Kuppe, Christoph. AU - Rohlfs, Wilko. AU - Grepl, Martin. AU - Schulte, Kevin. AU - Veron, Delma. AU - Elger, Marlies. AU - Sanden, Silja Kerstin. AU - Saritas, Turgay. AU - Andrae, Johanna. AU - Betsholtz, Christer. AU - Trautwein, Christian. AU - Hausmann, Ralf. AU - Quaggin, Susan. AU - Bachmann, Sebastian. AU - Kriz, Wilhelm. AU - Tufro, Alda. AU - Floege, Jürgen. AU - Moeller, Marcus J.. PY - 2018/9/1. Y1 - 2018/9/1. N2 - Background: Vascular endothelial growth factor A (VEGF) is an essential growth factor during glomerular development and postnatal homeostasis. VEGF is secreted in high amounts by podocytes into the primary urine, back-filtered across the glomerular capillary wall to act on endothelial cells. So far it has been assumed that VEGF back-filtration is driven at a constant rate exclusively by diffusion. Methods: In the present work, glomerular ...
TY - JOUR. T1 - Vascular endothelial growth factor induces protein synthesis in renal epithelial cells. T2 - A potential role in diabetic nephropathy. AU - Senthil, Duraisamy. AU - Choudhury, Goutam Ghosh. AU - McLaurin, Colby. AU - Kasinath, Balakuntalam S.. N1 - Funding Information: We thank Dr. D.J. Riley for helping with induction of diabetes and critical reading of the manuscript and Dr. N. Sonenberg, K. Walsh, for mutant constructs employed in this study. This study was supported by funding from the American Diabetes Association (B.S.K.), Veterans Administration Research Service (Merit and REAP awards for B.S.K. and G.G.C.), the National Institutes of Health (G.G.C. DK55815), and the National Kidney Foundation of South and Central Texas (D.S.).. PY - 2003/8/1. Y1 - 2003/8/1. N2 - Background. Vascular endothelial growth factor (VEGF) is an important determinant of ocular complications of diabetes. Its potential role in diabetic renal disease has not been extensively studied. Methods. We ...
Relationship Between Vascular Endothelial Growth Factor and Left Ventricular Dimension in Patients With Acute Myocardial Infarction.Relationship Between Vascular Endothelial Growth Factor and Left Ventricular Dimension in Patients With Acute Myocardial Infarction. ...
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is a homodimeric 34 to 45 kilodalton, heparin-binding glycoprotein. VEGF has potent angiogenic, mitogenic, and vascular permeability-enhancing activities specific for endothelial cells.1 VEGF is thought to play an important role in several physiologic processes, including wound healing, ovulation, menstruation, maintenance of blood pressure, and pregnancy.1 VEGF has also been associated with a number of pathologic processes that involve angiogenesis, including arthritis, psoriasis, macular degeneration, and diabetic retinopathy.1 In general, the growth and spread of tumors has been shown to be dependent on the development of increased vascularization in the tumor vicinity in order to maintain sufficient oxygenation.1 Tumor expression of proangiogenic factors, including VEGF, has been associated with advanced tumor progression in a number of human cancers.2,3 Increased expression of VEGF has been ...
Метою дослідження було визначення рівня васкулоендотеліального фактора росту у хворих на первинний гіпотиреоз. При обстеженні 133 пацієнтів з маніф...
Heroult M., Bernard-Pierrot I., Delbe J., Hamma-Kourbali Y., Katsoris P., Barritault D., Papadimitriou E., Plouet J., Courty J.. Heparin affin regulatory peptide (HARP) is an heparin-binding molecule involved in the regulation of cell proliferation and differentiation. Here, we report that HARP inhibited the biological activity induced by the 165-amino-acid form of vascular endothelial growth factor (VEGF165) on human umbilical vein endothelial cells. Endothelial-cell proliferation induced by VEGF165 showed about 50% inhibition in the presence of HARP in a concentration of 3 nM. In similar range of concentrations, HARP blocked tube formation induced by VEGF165 in three-dimensional angiogenesis assay. In vivo studies showed that HARP inhibited the VEGF165-induced Matrigel trade mark infiltration of endothelial cells. We then investigated the mechanisms of this inhibition and shown that HARP inhibited the binding of 125I-VEGF165 to the VEGF receptors of endothelial cells. Additional studies using ...
Members of the vascular endothelial growth factor (VEGF) family of proteins are critical regulators of angiogenesis. VEGF concentration gradients are important for activation and chemotactic guidance of capillary sprouting, but measurement of these gradients in vivo is not currently possible. We have constructed a biophysically and molecularly detailed computational model to study microenvironmental transport of two isoforms of VEGF in rat extensor digitorum longus skeletal muscle under in vivo conditions. Using parameters based on experimental measurements, the model includes: VEGF secretion from muscle fibers; binding to the extracellular matrix; binding to and activation of endothelial cell surface VEGF receptors; and internalization. For 2-D cross sections of tissue, we analyzed predicted VEGF distributions, gradients, and receptor binding. Significant VEGF gradients (up to 12% change in VEGF concentration over 10 μm) were predicted in resting skeletal muscle with uniform VEGF secretion, due to non
Vascular endothelial growth factor (VEGF) is definitely 1 of the many essential angiogenic growth factors for tumor angiogenesis. growth angiogenesis in MMP-2 suppressed growth areas was associated with decreased co-localization of MMP-2 and integrin-V3. In overview, these data offer fresh information into the systems root MMP-2-mediated VEGF appearance in lung growth angiogenesis. and versions. Our results reveal that MMP-2 transcriptional inactivation decreased integrin-V3-mediated considerably, PI3E/AKT-induced VEGF appearance, which reduced tumor cell-induced angiogenesis ultimately. Components AND Strategies Cells and Reagents A549 and L1299 lung adenocarcinoma cells had been cultured in RPMI 1640 (ATCC Manassas, Veterans administration) supplemented with 10% fetal bovine serum (Invitrogen, Carlsbad, California), 50 devices/mL penicillin, and 50 g/mL streptomycin (Existence Systems, Inc., Frederick, MD). For human being microvascular skin endothelial cells (HMEC-1), glutamine, EGF buy ...
Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as Tumor Angiogenesis Factor or Vascular Permeability Factor. Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability, it may play a role in stimulating Vasolidation via nitric oxide-dependent pathways. Alternative splicing of the mRNA for VEGF-A results in several isoforms of the protein being produced. Rat and bovine VEGF are one amino acid shorter than the human factor, and the bovine and human sequences show a homology of 95 percent. In contrast to other factors mitogenic for endothelial cells VEGF is synthesized as a precursor containing a typical hydrophobic secretory signal sequence of 26 amino acids. Glycosylation is not required for efficient secretion of VEGF. Recombinant rat VEGF produced in E. coli is a double, non-glycosylated, polypeptide chain of 165 amino acids ...
KEY POINTS: Combining nitric oxide (NO)-mediated increased blood flow with angiopoietin-1-Tie2 receptor signalling induces arteriolargenesis - the formation of arterioles from capillaries - in a model of physiological angiogenesis. This NO-Tie-mediated arteriolargenesis requires endogenous vascular endothelial growth factor (VEGF) signalling. Inhibition of VEGF signalling increases pericyte coverage in microvessels. Together these findings indicate that generation of functional neovasculature requires close titration of NO-Tie2 signalling and localized VEGF induction, suggesting that the use of exogenous VEGF expression as a therapeutic for neovascularization may not be successful. ABSTRACT: Signalling through vascular endothelial growth factor (VEGF) receptors and the tyrosine kinase with IgG and EGF domains-2 (Tie2) receptor by angiopoietins is required in combination with blood flow for the formation of a functional vascular network. We tested the hypothesis that VEGF and angiopoietin-1 (Ang1)
Background: Pharmacological inhibitors of vascular endothelial growth factor (VEGF) receptors, like vatalanib, have already been analyzed in randomised trials (CONFIRM (Colorectal Dental Book therapy For the Inhibition of Angiogenesis and Retarding of Metastases) 1 and 2) in colorectal cancer showing activity inside a subgroup of individuals with high serum LDH expression. the placebo group was mentioned (response prices (RRs) 15% (3/20) when high VD 52% (26/50) when low VD; 39 and 40 31, respectively). Therefore, evaluation was performed in mixed CONFIRM 1 and 2 data models, no split analysis 781649-09-0 was attempted due to the low amount of cells collected relatively. So that they can investigate the association of PTZK/ZK restorative activity with tumour angiogenesis and anaerobic metabolic pathways, 781649-09-0 paraffin-embedded materials from 164 individuals with metastatic colorectal adenocarcinoma had been recruited within the CONFIRM 1 and 2 tests. This group of individuals continues to ...
Previous work showed that connexin 43 (Cx43) reduced the expression of hypoxic-induced factor-1α (HIF-1α) in astrocytes. HIF-1α is a master transcription factor for angiogenesis in tumor. Angiogenesis is essential for tumor progression. Here, we investigated the role of Cx43 in vascular endothelial growth factor (VEGF) production and angiogenesis in murine tumor. In the study, mouse B16F10 and 4T1 cells were overexpressed or knockdown with Cx43. The expression profiles as well as activity of the treated cells were examined. Furthermore, reduced Cx43 expression in B16F10 and 4T1 cells causes increased expression of VEGF and enhanced the proliferation of endothelial cells. On the contrary, the expression of VEGF and the proliferation of endothelial were increased in the conditioned medium of Cx43-knockdown tumor cells. We subcutaneously transplanted Cx43-overexpressing B16F10 cells into mice to evaluate the roles of Cx43 in the tumor angiogenesis. Both tumor size and the number of vessels growing in
Yasuhara, T., Shingo, T., Kobayashi, K., Takeuchi, A., Yano, A., Muraoka, K., Matsui, T., Miyoshi, Y., Hamada, H. and Date, I. (2004), Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinsons disease. European Journal of Neuroscience, 19: 1494-1504. doi: 10.1111/j.1460-9568.2004.03254.x ...
Abramovich D, Irusta G, Parborell F and Tesone M (2010). Intrabursal injection of vascular endothelial growth factor trap in eCG-treated prepubertal rats inhibits proliferation and increases apoptosis of follicular cells involving the PI3K/ AKT signaling pathway. Fertil. Steril. 93: 1369-1377. http://dx.doi.org/10.1016/j.fertnstert.2009.01.127 PMid:19328472 Accili D and Arden KC (2004). FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117: 421-426. http://dx.doi.org/10.1016/S0092-8674(04)00452-0 Barboni B, Turriani M, Galeati G, Spinaci M, et al. (2000). Vascular endothelial growth factor production in growing pig antral follicles. Biol. Reprod. 63: 858-864. http://dx.doi.org/10.1095/biolreprod63.3.858 PMid:10952932 Brummelkamp TR, Bernards R and Agami R (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553. http://dx.doi.org/10.1126/science.1068999 PMid:11910072 Bruno JB, Celestino JJ, Lima-Verde IB, ...
RPA143Mu01, Recombinant Vascular Endothelial Growth Factor A (VEGFA), 血管内皮生长因子A(VEGFA)重组蛋白, VEGF; VEGF-A; VPF; Vascular Endothelial Cell Growth Factor A; Vascular Permeability Factor | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
Context:Multiple genes and proteins have been shown to be important in treatment and prognosis of breast cancer, including the estrogen and progesterone receptors and Her-2 neu. Vascular endothelial growth factor (VEGF) subtypes have been shown to be associated with lympho-vascular invasion, lymph node metastases and prognosis in multiple types of cancer, including colon cancer, gastric cancer and breast cancer. The goal of this project was to observe and quantify the protein expression of VEGF subtypes in human breast cancer, then correlate this with known clinicopathologic information. Design:Ninety grade three (high grade) invasive ductal carcinomas received over a four year period (1997-2001) were selected from our files. Immunohistochemistry was performed on formalin fixed paraffin embedded tissue of both primary tumor and lymph node metastasis when applicable using VEGF-A, VEGF-C, VEGF-D and VEGF-R (the VEGF receptor) antibodies. The staining was graded from zero (no expression) to 3+ (high
TY - JOUR. T1 - Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding. AU - Agergaard, Jakob. AU - Reitelseder, Søren. AU - Pedersen, T.G.. AU - Doessing, Simon. AU - Schjerling, Peter. AU - Langberg, Henning. AU - Miller, Benjamin F. AU - Aagaard, P. AU - Kjær, Michael. AU - Holm, Lars. PY - 2013/3/20. Y1 - 2013/3/20. N2 - INTRODUCTION: We examined short-term (3-hour) and long-term (12-week) training effects after heavy load [HL; 70% 1RM] and light load (LL; 16% 1RM) exercise. METHODS: mRNA expression of genes involved in skeletal muscle remodeling were analyzed and muscle activity (EMG measurements) was measured. RESULTS: Relative muscle activity differed between HL and LL resistance exercise, whereas median power frequency was even, suggesting an equal muscle-fiber-type recruitment distribution. mRNA expression of Myf6, myogenin, and p21 was mostly increased, and myostatin was mostly depressed by HL resistance exercise. No ...
Vascular endothelial growth factor A (VEGF-A), also known as Vascular Permeability Factor or VEGF165, is a potent mitogenic and angiogenic disulfide-linked homodimer responsible for angiogenesis in several organs including the CNS. VEGF-A has been shown to increase extravasation of proteins from tumor associated capillaries, thus the monicker Vascular Permeability Factor. VEGF-A is part of the VEGF family of proteins which includes VEGF-B, VEGF-C, VEGF-D, and placental growth factor. VEGF-A expression is increased by reduced blood flow and ischemia, and is involved in the growth and expansion of tumors in a cycle where tumor growth results in ischemia, which increases VEGF-A expression resulting in angiogenesis and further tumor growth. Furthermore, VEGF-A is secreted from tumors, which has made it a primary objective for development of the VEGF-A antagonist bevacizumab (Avastin, Roche). Bevacizumab is used as an adjuvant chemotherapeutic agent in the treatment of metastatic colon cancer, ...
The role of vascular endothelial growth factor and mesenchymal stem cells during angiogenesis, Nanae Oki, Takaharu Abe, Ryo Kunimatsu, Keisuke Sumi, Tetsuya Awada, Yuji Tsuka, Keng
We conclude that HIF-1 is the regulatory link between tumor hypoxia and VEGF production in pancreatic cancer, thus establishing a biochemical pathway between tumor hypoxia and neoangiogenesis in this highly aggressive neoplasm.
The objective of this study was to determine the tumor distribution of temozolomide, an alkylating agent, in the absence and presence of the angiogenesis inhibitor 3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]indolin-2-one (SU5416), a specific vascular endothelial cell growth factor receptor 2 inhibitor. The study was conducted in nude rats bearing either subcutaneous or intracerebral tumors that overexpressed vascular endothelial cell growth factor. For both tumor locations, animals were assigned to either of two treatment groups, SU5416 (25 mg/kg, dissolved in dimethyl sulfoxide) or vehicle control, dimethyl sulfoxide (710 μl/kg) administered i.p. every day for a total of nine doses. Twenty-four hours after the last dose of SU5416 or dimethyl sulfoxide, temozolomide was administrated as a steady-state infusion regimen designed to achieve target plasma concentrations (Cp) of 20 μg/ml. In addition to the measurement of temozolomide Cp, tumor interstitial fluid unbound concentrations of ...
Despite the assumed importance of VEGF in the progression of cancer, relatively few studies of the expression of this protein in ovarian cancer have been linked to comprehensive clinical data, particularly data on survival.. The distribution of histologic subtypes is consistent with established literature, with serous carcinoma being the most prevalent followed by endometrioid and mucinous (1). The typical distribution of ovarian cancer in relation to stage and differentiation is seen with the majority presenting with poorly differentiated, advanced (stage III and IV) disease (24). The clinicopathologic features correlate with established characteristics of ovarian cancer, suggesting that the study contains a representative cohort of patients, and hence, the study findings will be of relevance to a general population.. The expression of VEGF in our patients exhibited a similar pattern to that of Goodheart et al. (19), with a strong expression seen in 6.9% of the tumors. Lesser expression ranged ...
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Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Bevacizumab is a recombinant Human IgG;κ monoclonal antibody specific for all human vascular endothelial growth factor A (VEGF-A) isoforms.
Bevacizumab is a recombinant Human IgG;κ monoclonal antibody specific for all human vascular endothelial growth factor A (VEGF-A) isoforms.
Thymidine phosphorylase (EC 2.4.2.4) catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate. This enzyme regulates the availability of thymidine and is therefore essential to nucleic acid metabolism. In Escherichia coli (gene deoA), the enzyme is a dimer of identical subunits of about 48 Kd [1]. In humans it was first identified as platelet-derived endothelial cell growth factor (PD-ECGF) before being recognized [2] as thymidine phosphorylase. Bacterial pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) (gene pdp) [3] is an enzyme evolutionary and structurally related to thymidine phosphorylase. As a signature pattern for these enzymes, we selected a well conserved region of 19 residues located in the N-terminal part of these proteins. Last update: April 2006 / Pattern revised. ...
TY - JOUR. T1 - Coffee induces vascular endothelial growth factor (VEGF) expression in human neuroblastama SH-SY5Y cells. AU - Kakio, Shota. AU - Tago, Megumi. AU - Kobata, Kenji. AU - Tamura, Hiroomi. PY - 2016/1/21. Y1 - 2016/1/21. N2 - Recent evidence indicates that hypoxia-inducible vascular endothelial growth factor (VEGF) has neurotrophic and neuroprotective effects on neuronal and glial cells. On the other hand, recent epidemiological studies showed that daily coffee consumption has been associated with a lower risk of several neuronal disorders. Therefore, we investigated the effect of coffee on VEGF expression in human neuroblastoma SH-SY5Y cells. We found that even low concentration of coffee (. AB - Recent evidence indicates that hypoxia-inducible vascular endothelial growth factor (VEGF) has neurotrophic and neuroprotective effects on neuronal and glial cells. On the other hand, recent epidemiological studies showed that daily coffee consumption has been associated with a lower risk ...
In recent years, vascular inflammation, marked by activated monocytes and endothelium, has been proven to play a significant role in the pathogenesis of vasoocclusive events (VOEs) in sickle cell disease (SCD). Vascular endothelial growth factor ( VEGF), an endothelial cell mitogen, has been shown to contribute to the increased endothelial cell adhesivity by increasing the expression of cell adhesion molecules ICAM-1 ( intercellular adhesion molecule-1) and VCAM-1 ( vascular cell adhesion molecule-1) on the endothelium. We have investigated VEGF alterations in 37 patients with SCD during VOEs and/or steady state. VEGF levels ( mean +/- SEM) were found to be significantly elevated during VOEs ( 703.1 +/- 119.0 pg/ml) when compared with those at steady state (258.0 +/- 57.8 pg/ml) and healthy controls (196.6 +/- 21.9 pg/ml) ( p< 0.001). However, we did not find a difference between VEGF concentrations in sickle patients at steady state and the normal subjects ( p> 0.05). We suggest that ...
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014 ...
Hypoxia is a key regulatory factor in tumour growth, activating angiogenesis, glycolysis and cell migration. It is readily recognized by the intracellular accumulation of hypoxia-inducible factor 1alpha (HIF1alpha) and HIF2alpha. Accumulation of HIF1alpha and HIF2alpha was detected immunohistochemically in a series of 46 nodular malignant melanomas of the skin (epithelioid cell variant), treated with wide local excision. The results were correlated with vascular density (VD) and expression of the angiogenesis-stimulating factors vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP). Further associations were sought with patient prognosis and the important histopathological features of Breslows thickness, Clarks level of invasion, mitotic rate, inflammatory cell infiltrates and tumour ulceration. HIF1alpha and HIF2alpha accumulation in malignant melanomas was directly correlated with VEGF expression. Tumours with high VEGF or HIF2alpha expression were associated with a poorer
TY - JOUR. T1 - Vascular endothelial growth factor is increased during early stage of diabetic nephropathy in type II diabetic rats. AU - Cha, Dae-Ryong. AU - Kang, Young Sun. AU - Han, Sang Youb. AU - Jee, Yi Hwa. AU - Han, Kum Hyun. AU - Han, Jee Young. AU - Kim, Young Sik. AU - Kim, Nan Hee. PY - 2004/10/1. Y1 - 2004/10/1. N2 - Vascular endothelial growth factor (VEGF) has been implicated in the pathogenesis of diabetic nephropathy. We investigated serial changes of VEGF in the kidney and assessed whether glomerular and urinary VEGF levels are related to the severity of diabetic nephropathy. Furthermore, we examined the relationship between urinary VEGF levels and the urinary albumin excretion (UAE) rate in Otsuka-Long-Evans-Tokushima-Fatty (OLETF) rats. Glomerular VEGF mRNA expression and protein synthesis were evaluated by the reverse transcription-polymerase chain reaction, immunohistochemical staining and in situ hybridization. Urinary levels of VEGF were determined by enzyme-linked ...
Up-regulation of vascular endothelial growth factor (VEGF) expression is a major event leading to neovascularization in malignant gliomas. Hypoxia is believed to be the crucial environmental stimulus for this up-regulation. To critically assess this hypothesis, we asked whether the mechanisms defined previously for hypoxia-induced VEGF expression in vitro are similarly involved and sufficient for up-regulation of VEGF gene expression in vivo, using a lacZ reporter gene under the control of VEGF regulatory sequences in an experimental glioma model. Inclusion of the binding site for hypoxia-inducible factor 1 (HIF 1) in the 5′ regulatory sequences used in the hybrid gene produced weak β-galactosidase staining in a special tumor cell subtype, the so-called perinecrotic palisading (PNP) cells that flank necrotic regions within the tumor. Deletion of the HIF 1 binding site abolished reporter gene expression in the PNP cells, indicating that transcriptional activation of VEGF expression in gliomas ...
TY - JOUR. T1 - A Molecular Mechanism Regulating Circadian Expression of Vascular Endothelial Growth Factor in Tumor Cells. AU - Koyanagi, Satoru. AU - Kuramoto, Yukako. AU - Nakagawa, Hiroo. AU - Aramaki, Hironori. AU - Ohdo, Shigehiro. AU - Soeda, Shinji. AU - Shimeno, Hiroshi. PY - 2003/11/1. Y1 - 2003/11/1. N2 - Because angiogenesis is essential for tumor growth and metastasis, inhibition of angiogenesis has emerged as a new therapy to treat cancers. Hypoxia-induced expression of vascular endothelial growth factor (VEGF) plays a central role in tumor-induced angiogenesis. In this study, we found that expression of VEGF in hypoxic tumor cells was affected by the circadian organization of molecular clockwork. The core circadian oscillator is composed of an autoregulatory transcription-translation feedback loop in which CLOCK and BMALL are positive regulators, and Period and Cryptochrome genes act as negative ones. The levels of VEGF mRNA in tumor cells implanted in mice rose substantially in ...
Vascular endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene. VEGF-B is a growth factor that belongs to the vascular endothelial growth factor family, of which VEGF-A is the best-known member. In contrast to VEGF-A, VEGF-B plays a less pronounced role in the vascular system: Whereas VEGF-A is important for the formation of blood vessels, such as during development or in pathological conditions, VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. VEGF-B plays also an important role on several types of neurons. It is important for the protection of neurons in the retina and the cerebral cortex during stroke and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis. VEGF-B exerts its effects via the FLT1 receptor. VEGF-B has also been found to control endothelial uptake and transport of fatty acids in heart and skeletal muscle. Vascular endothelial ...
Patients in renal failure on hemodialysis depend on adequate and sustained vascular access. This can be achieved by surgical placement of a synthetic polytetrafluoroethylene (PTFE) graft. These patients frequently experience graft complications arising from the development of smooth muscle cell (SMC) neointimal hyperplasia in the proximity of the graft-vein anastomosis. Such complications eventually lead to stenosis, access thrombosis and graft failure. Trinam® is being developed to prolong graft survival. It is a combination product consisting of a replication deficient Adenovirus containing the human Vascular Endothelial Growth Factor D (Ad-VEGF-D) gene and a biodegradable local delivery device (collar) made of collagen. At the end of the surgical procedure to insert the PTFE graft the collagen collar is applied around the anastomosis and sealed with a collagen surgical sealant. This procedure creates a reservoir between the site of anastomosis and the collagen collar. The adenoviral vector ...
BDNF and VEGF were analyzed as continuous variables. VEGF values were log-transformed to normalize the skewed distribution of VEGF. We used Cox-proportional hazards models to relate baseline serum BDNF and logVEGF levels (separately) to risk of incident stroke/TIA in Study Sample 1. We first examined the linear effect of a 1-SD unit increase/decrease in BDNF and logVEGF on risk of stroke/TIA. We also explored threshold effects comparing the risk across quartiles of BDNF and VEGF. We observed a threshold effect with BDNF only. Therefore, we ran threshold models for BDNF using the lowest quartile, Q1, as the reference and also assessed a threshold model comparing risk for persons in Q1 with persons in Q2 to Q4. We performed a similar set of analyses on a Study Sample 1b with stroke alone as the outcome. Using multivariable linear and logistic regression models, we examined the cross-sectional associations between BDNF and logVEGF and markers of brain aging (WMHV, and VR-d and Trails B-A ...
|p||span|Recombinant Human Vascular Endothelial Growth Factor 121 is a homodimer containing two non-glycosylated, polypeptide chains of 121 amino acids each.|/span||/p| |p|Background: Vascular endothelial growth factor is an important signaling protein i
Both advanced glycation end products and vascular endothelial growth factor are believed to play a role in the pathogenesis of diabetic retino pathy. It is known that vascular endothelial growth facto
This study will look for the presence in blood of a substance called vascular endothelial growth factor (VEGF) in patients with uveitis (eye inflammation). It will also look for this substance in eye fluid samples taken from patients with uveitis who are undergoing eye surgery.. Some patients with uveitis experience some vision loss during an inflammatory attack because of swelling (edema) in a particular area of the retina called the macula, which is involved in visual acuity. It may be that VEGF is involved in the development of macular edema.. Patients with uveitis who participate in this study will have about 10 cc (2 teaspoons) of blood drawn to be examined for VEGF. They will also undergo a procedure called fluorescein angiography to look at the blood vessels of the eye. A dye called sodium fluorescein is injected into the blood stream through a vein. After the dye reaches the blood vessels of the eye, photographs are taken of the retina.. In addition, patients with uveitis who are ...
Vascular Endothelial Growth Factor (VEGF), A Major Regulator Of Angiogenesis, Binds To Two Receptor Tyrosine Kinases, KDR/Flk-1 And Flt-1. We Now Describe The Purification And The Expression Cloning From Tumor Cells Of A Third VEGF Receptor, One That
Increasing evidence suggests that cerebral vascular dysfunction is associated with the early stages of Alzheimers disease (AD). Vascular endothelial growth factor (VEGF) is one of the key players involved in the development and maintenance of the vasculature. Here, we hypothesized that VEGF levels in cerebrospinal fluid (CSF) may be altered in AD patients with vascular involvement, characterized by the presence of microbleeds (MB), and in vascular dementia (VaD) patients compared to controls. VEGF levels were determined by electrochemilumiscence Meso Scale Discovery (MULTI-SPOT Assay System) in CSF from age-matched groups of controls with subjective cognitive decline (n = 21), AD without MB (n = 25), AD with MB (n = 25), and VaD (n = 21) patients. The average level of VEGF in the different groups was 2.8 ± 1 pg/ml CSF. Adjusted for age and gender, no significant differences were detected between groups (p | 0.5). However, we detected a significant correlation between the concentration of VEGF in the
The vascular endothelial growth factor 165 (VEGF165) is the predominant form of thecomplex VEGF family. This glycoprotein has, among others, an angiogenic effect inmany physiological and pathological events. For this reason, its roles as a biomarker andas a therapeutic drug have been considered. However, very little is known about theexistence of different forms of VEGF165 arising from glycosylation and other potentialPTMs. This aspect is crucial because it is known that for other glycoproteins the ratiobetween these isoforms actually acts as a biomarker for certain diseases and otherphysiological states. In addition, for therapeutic use of glycoproteins it is known that thebiological activity may differ for the various isoforms. In this work CE methods toseparate up to seven peaks without baseline resolution containing various forms ofVEGF165 are developed. Using a computer program previously developed in-house peakassignment could be performed with accuracy close to 100%. In this way, ...
This study assessed the effects of bromocriptine on serum vascular endothelial growth factor (VEGF) levels in women undergoing in vitro fertilisation.
Significantly higher expression of vascular endothelial growth factor (VEGF) and shorter survival after recurrences in premenopausal node negative patients with triple negative breast cancer in CANCER RESEARCH, vol 69, issue 2, pp 128S-129S ...
Fingerprint Dive into the research topics of Role of protein tyrosine phosphatase ib in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells. Together they form a unique fingerprint. ...
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|b||i|Background:|/i||/b| Lactate dehydrogenase 5 (LDH5) is a major lactate dehydrogenase isoenzyme catalyzing the transformation of pyruvate to lactate to provide anaerobic en
Vascular endothelial growth factor (VEGF) was originally identified as an endothelial cell specific growth factor stimulating angiogenesis and vascular permeability. Some family members, VEGF C and D, are specifically involved in lymphangiogenesis. It now appears that VEGF also has autocrine functions acting as a survival factor for tumour cells protecting them from stresses such as hypoxia, chemotherapy and radiotherapy. The mechanisms of action of VEGF are still being investigated with emerging insights into overlapping pathways and cross-talk between other receptors such as the neuropilins which were not previously associated with angiogenesis. VEGF plays an important role in embryonic development and angiogenesis during wound healing and menstrual cycle in the healthy adult. VEGF is also important in a number of both malignant and non-malignant pathologies. As it plays a limited role in normal human physiology, VEGF is an attractive therapeutic target in diseases where VEGF plays a key role. It was
Under HBO therapy a significant reduction of bFGF was detected. The concentration of VEGF did not change but was measured significantly higher in female test persons. All collected results were within the range of standard values according to the current literature.. The influence of the ischemic inner-ear disorder for which the HBO group was treated could not be fully excluded as an interfering factor. Yet it seemed highly implausible because so far only grave diseases have been reported to affect bFGF and VEGF concentration [20]. There are several explanations for the reduced bFGF level under HBO. One hypothesis states that there are simply more bFGF molecules binding on their receptor and transmitting their signal. These molecules are no longer detectable for the performed assays.. There might be a higher rate of binding on circulation proteins in the course of repair processes: these ligand-receptor complexes are possibly the activating agents inducing fibroblast proliferation, collagen ...
摘要(Abstract): 目的观察丰富环境(enriched environment,EE)对大鼠脑缺血再灌注(cerebral ischemia reperfusion,CIR)损伤后血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的影响。方法将成年雄性SD大鼠64只随机分为正常组、假手术组、CIR模型组和EE干预组,每组16只。采用Longa法建立大鼠大脑中动脉缺血再灌注模型。EE干预组大鼠给予EE饲养,其余大鼠均按照标准环境饲养,共饲养14 d。于EE干预的第1天及第14天观察大鼠脑缺血半暗带组织病理形态学改变;采用实时荧光定量PCR(qRT-PCR)检测大鼠脑缺血半暗带VEGF mRNA表达;采用免疫组化检测大鼠脑缺血半暗带VEGF蛋白表达。结果 EE干预的第1天,正常组与假手术组大鼠脑组织结构清晰,神经元排列规则,细胞核仁清晰,CIR模型组与EE干预组大鼠脑缺血半暗带均出现水肿、神经元脱失等病理改变;CIR模型组和EE干预组大鼠脑缺血半暗带VEGF ...
家兎瞳孔膜退縮期における前房水中の血管内皮増殖因子(VEGF)および線維芽細胞増殖因子(bFGF)濃 ...
Background Angiogenesis, partly mediated by vascular endothelial growth factor (VEGF), promotes metastases. BEV, an anti-VEGF monoclonal antibody which has some efficacy in metastatic BC is being studied as an adjuvant treatment for ESBC. However, there are no validated biomarkers, and the effects of BEV on VEGF levels in pts with ESBC is unknown. We studied VEGF serum concentration in ESBC receiving BEV.. Methods 106 pts with HER-2 negative ESBC were included in this study. Patients received 4 cycles of docetaxel (75 mg/m2) + cyclophosphamide (600 mg/m2) with BEV (15 mg/kg) once every three weeks for one year. Serum samples were collected prior to commencement of treatment, at 6 months and 12 months. The VEGF levels in serum samples were determined, at each time point, using a VEGF enzyme-linked immunosorbent assay (ELISA).. Results VEGF concentration was determined in serum samples from 65 patients. Serum VEGF was detectable in 62 of 65 patients and the median level in untreated patients was ...
A class of proteins that causes new blood vessel growth (angiogenesis) and maintains the natural leakiness inherent in vessels. These are normal body functions, which, if they happen where they shouldnt (such as in the retina), can cause disease, such as AMD.
What does this mean?. This is the first paper, leap, convincingly demonstrated that VEGF and c-Met at the same time, not only reduces the size of the tumor, but also invasion and metastasis, thereby overcoming the separate and vascular endothelial growth factor inhibitors One of the limitations of treatment.. This work in progress, anti-angiogenic process, which involves our understanding of:. A complex mechanism involving the pruning of blood vessels within the tumor hypoxia, HIF-1a accumulation and activation of c-Met in tumor cells.. Therefore, the data also show that the value of vascular endothelial growth factor binding, and met with treatment, such as cabozantinib (XL184 inhibitor:. XL184 is the inhibition of two signaling pathways also reduced the tumor growth, invasion and metastasis and prolong survival.. In general, this is a very nice put together to study films and expand the understanding of our angiogenesis. It also provides how we can improve insight and met with suppression of ...
Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene. Vascular endothelial growth factor A (VEGF-A) is a dimeric glycoprotein that plays a significant role in neurons and is considered to be the main, dominant inducer to the growth of blood vessels. VEGFA is essential for adults during organ remodeling and diseases that involve blood vessels.. VEGF-A has been implicated with poor prognosis in breast cancer. VEGF-A is also released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and swelling and also stimulating angiogenesis. VEGF-A is also important in diabetic retinopathy (DR). VEGF-A plays a role in the disease pathology of the wet form age-related macular degeneration (AMD), which is the leading cause of blindness for the elderly of the industrialized world. Once released, VEGF-A may elicit several responses. It may cause a cell to survive, move, or further differentiate. Hence, VEGF is a potential target for ...
Vascular Endothelial Growth Factor is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells.
As with all tracers, the uptake of 111In-labled VEGF121 depends to some extent on flow to the target tissue. We chose the rabbit hindlimb model in part because the mass of hindlimb muscle in the rabbit (unlike cardiac tissue) allowed us to achieve acceptable count statistics. In this model, however, collateralization is relatively sparse, and although we did not directly measure flow, previous studies confirm significant hypoperfusion of tissue under the conditions specified in the present experiments.10 To decrease the effect of low flow on isotope delivery, we waited 3 hours before gamma counting to allow greater time for binding.. Increased 111In-labled VEGF121 activity in the ischemic hindlimb may have reflected nonspecific retention of the isotope due to prolonged tracer washout in the setting of low flow. The persistence of differential uptake of 111In-labled VEGF121 by ischemic muscle up to 48 hours and the comparably low uptake of 125I-HSA in ischemic and nonischemic hindlimb argue ...
Epidermal Growth Factor, Fibroblast Growth Factor, Tyrosine, Uridine, Cell, Cancer, Endothelial Growth Factor, Vascular Endothelial Growth Factor, Oxygen, Blood, Blood Vessels, Diseases, and Tissue
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Vascular endothelial growth factor (VEGF)-B, 1 of the 5 members of the VEGF family,1 is relatively understudied compared to VEGF-A, yet is emerging as a major cytoprotective factor.2,3 Expressed in tissues with elevated metabolism, including myocardium,4 the VEGF-B gene encodes for 2 isoforms, VEGF-B167 and VEGF-B186, which selectively bind the receptors VEGFR-1 and neuropilin-1.4,5 Based on data from knockout and transgenic animals, this growth factor is minimally angiogenic and its absence is compatible with birth and growth, although it seems important for physiological cardiac development.6-8 Li et al have recently elucidated mechanisms responsible for VEGF-B-induced cytoprotection: VEGF-B167, via VEGFR-1, downregulates genes of the apoptosis/cell death-related pathways, in vitro, and can rescue neurons from apoptosis in mouse models of retinal and brain damage.2 The same authors found that, under pathological conditions, VEGF-B167, albeit unable to induce blood vessel growth, is critically ...
VHL gene deletion and enhanced VEGF gene expression detected in the stromal cells of retinal angioma.: These findings suggest that vacuolated stromal cells re
Materials And Methods: A total of 30 male Wistar albino rats weighing 250-280 g were used in this study. In addition, 2-cm-long skin incisions were created over bilaterally exposed skin of the tibia region in each rat. VEGF plasmid 2 μg was administered locally into the right side wound bed of each animal. No other procedure besides skin closure was administered on the left side. To determine histologic assessments, skin samples were obtained from six anesthetized rats at each interval (4, 8, 12, 16 and 30 days) through excisional biopsy. The tissues were fixed in 10% neutral-buffered formalin for 1 week and then embedded in paraffin wax. Transverse sections of the embedded tissue 5-7 μm thick were stained with hematoxylin and eosin (H and E ...
Keywords: placenta, cancer of the colon, endothelium, VEGF, immunohistochemistry, angiogenesis Vascular endothelial development element A (VEFG-A), probably the most prominent person in the VEGF family, is one of the key regulators of angiogenesis in general, including the promotion of tumor progression and metastasis (Kim et al. 1993; Ferrara et al. 2003). The important role of this growth factor in different areas of biological sciences makes it therefore an interesting target in many immunohistochemical studies. At present, at least nine different primary anti-VEGF antibodies are commercially available that can be applied to formalin-fixed and paraffin-embedded tissue samples (Table 1). Considering the literature on VEGF IHC applications, there is surprisingly little discussion about the selection of the applied VEGF antibody, and no consensus on which VEGF antibody is most reliable. In an attempt to validate five VEGF antibodies, Zhang et al. (1998) reported the R and D Systems mouse ...
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Collection Container/Tube: Lavender-top (EDTA). Submission Container/Tube: Plastic vial. Specimen Volume: 0.5 mL. Collection Instructions:. 1. Immediately after specimen collection, place the tube on wet ice.. 2. Centrifuge at 1,500 x g for 10 minutes and aliquot plasma.. 3. Freeze specimen within 30 minutes.. ...
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Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression.: Hypoxia can select for cells that have lost
Anti-vascular endothelial growth factor (VEGF)[edit]. *Bevacizumabα. Medicines for reproductive health and perinatal care[edit] ...
"Nerve Growth Factor-Induced Angiogenesis: 1. Endothelial Cell Tube Formation Assay". Neurotrophic Factors. Methods in Molecular ... "Down-regulation of Epidermal Growth Factor Receptors by Nerve Growth Factor in PC12 Cells Is p140trk-, Ras-, and Src-dependent ... "Transcriptional Down-regulation of Epidermal Growth Factor (EGF) Receptors by Nerve Growth Factor (NGF) in PC12 Cells". Journal ... "Transcriptional Down-regulation of Epidermal Growth Factor (EGF) Receptors by Nerve Growth Factor (NGF) in PC12 Cells". Journal ...
Vascular endothelial growth factor 1. Isner JM. Therapeutic angiogenesis: a new frontier for vascular therapy. Vasc Med. 1996 1 ... Spatiotemporal control over growth factor signaling for therapeutic neovascularization. Adv Drug Deliv Rev. 2007 Nov 10;59(13): ...
... epidermal growth factor receptor; MoAbs, monoclonal antibodies; VEGF, vascular endothelial growth factor. The major challenge ... Ono, Koji (28 March 2016). "An analysis of the structure of the compound biological effectiveness factor". Journal of Radiation ... In vivo growth suppression of experimental melanoma solid tumor". Cancer Letters. 150 (2): 177-82. doi:10.1016/S0304-3835(99) ...
"Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)". ... Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene. Oncogene FLT belongs to ... FLT1 has been shown to interact with PLCG1 and vascular endothelial growth factor B (VEGF-B). VEGF receptors GRCh38: Ensembl ... Shibuya M (2007). "Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis". ...
Lee J, Gray A, Yuan J, Luoh SM, Avraham H, Wood WI (March 1996). "Vascular endothelial growth factor-related protein: a ligand ... This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be ... Petrova TV, Makinen T, Alitalo K (November 1999). "Signaling via vascular endothelial growth factor receptors". Experimental ... "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 ( ...
"Vascular endothelial growth factor gene therapy - HSCI". Adis Insight. Springer Nature Switzerland AG. "Gene Therapy for PAD ... it delivers the gene encoding for vascular endothelial growth factor (VEGF). Neovasculogen is a plasmid encoding the CMV ...
"Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor ... regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature". Current Opinion in ... Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (June 2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 ... January 2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human ...
... such as Von Willebrand factor and vascular endothelial growth factor (VEGF). These substances could also have a role in PDP ... platelet-derived growth factor (PDGF) and epidermal growth factor (EGF). It has not been described yet what role these ... 2000). "Vascular endothelial growth factor and hypertrophic osteoarthropathy". Clin Exp Rheumatol. 18 (1): 57-62. PMID 10728444 ... Von Willebrand factor is a marker of platelet and endothelial activation. This suggests that the activation of endothelial ...
"Napoleone Ferrara and the saga of vascular endothelial growth factor". Endothelium: Journal of Endothelial Cell Research. 15 (1 ... NGF or nerve growth factor, a protein involved primarily in the growth, as well as the maintenance, proliferation, and survival ... vascular endothelial growth factor' in 1989, while working at Genentech. He is credited with developing a whole new class of ... "The Multiple Life of Nerve Growth Factor: Tribute to Rita Levi-Montalcini (1909-2012)". Balkan Medical Journal. 30 (1): 4-7. ...
Vascular endothelial growth factor production and thereby of tumor vascularization; regulation of endothelial cell motility and ... interference with transformng growth factor-β's anti-cell proliferation activity; and, more recently, regulation of host anti- ... Scandella E, Men Y, Gillessen S, Förster R, Groettrup M (August 2002). "Prostaglandin E2 is a key factor for CCR7 surface ... PKA activates various types of signaling molecules such as the transcription factor CREB which lead to different types of ...
Some growth factors, such as vascular endothelial growth factor, are also capable of directly acting as mitogens, causing ... Other well-known mitogenic growth factors include platelet derived growth factor (PDGF) and epidermal growth factor (EGF). ... This is not true for all growth factors, as some growth factors instead appear to cause mitogenic effects like growth ... "Vascular Endothelial Growth Factor is a Secreted Angiogenic Mitogen". 8 December 1989, Science, Vol. 246, pp 1306-1309. Morgan ...
Another agent involved in autocrine cancer signaling is vascular endothelial growth factor (VEGF). VEGF, produced by carcinoma ... Weigand, Melanie; Hantel, Pia; Kreienberg, Rolf; Waltenberger, Johannes (2005). "Autocrine vascular endothelial growth factor ... One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors. ... For example, despite widespread expression of epidermal growth factor receptors (EGFRs) and EGF family ligands in non-small- ...
Mousa SA, Mousa SS (June 2010). "Current status of vascular endothelial growth factor inhibition in age-related macular ... Ferrara N, Adamis AP (June 2016). "Ten years of anti-vascular endothelial growth factor therapy". Nature Reviews. Drug ... Examples of RNA aptamer molecular targets and potential targets include vascular endothelial growth factor, osteoblasts, and C- ... For instance, siRNA can be used to target mRNAs that code for proteins that promote tumor growth such as the VEGF receptor and ...
Vascular endothelial growth factor (VEGF) and enhanced green fluorescent protein (EGFP) cDNA was ligated to either side of an ... Leung, D.; Cachianes, G; Kuang, W.; Goeddel, D.; Ferrara, N (1989). "Vascular endothelial growth factor is a secreted ... engineered cells produce a bioluminescent marker and a chemotactic growth factor. In this instance, increased fluorescence of ... A key factor that differentiates molecular processors is "the ability to control output" of protein or peptide concentration as ...
April 2005). "Vascular endothelial growth factor in pleural effusions of different origin". Eur. Respir. J. 25 (4): 600-4. doi: ... been shown to be raised in malignant pleural effusions compared to benign disease include vascular endothelial growth factor ( ... Clinical factors predicting the diagnosis of malignant pleural effusions are symptoms lasting more than 1 month and the absence ...
... vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and transforming growth factor-β (TGF-β). These ... Rini BI (February 2007). "Vascular endothelial growth factor-targeted therapy in renal cell carcinoma: current status and ... Hugo H. Marti, "Vascular Endothelial Growth Factor", Madame Curie Bioscience Database, Landes Bioscience, retrieved January 25 ... inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex". ...
Growth_Factor_Receptor - the Vascular Endothelial Growth Factor Receptor Structure in Interactive 3D Biology portal. ... July 2008). "Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc". ... "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor ... Vascular endothelial growth factor (VEGF) is an important signaling protein involved in both vasculogenesis (the formation of ...
It works by slowing the growth of new blood vessels by inhibiting vascular endothelial growth factor A (VEGF-A), in other words ... Its development was based on the discovery of human vascular endothelial growth factor (VEGF), a protein that stimulated blood ... Ferrara N (2011). "From the discovery of vascular endothelial growth factor to the introduction of avastin in clinical trials ... Ribatti D (2008). "Napoleone Ferrara and the saga of vascular endothelial growth factor". Endothelium. 15 (1): 1-8. doi:10.1080 ...
"Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization". ... Vascular endothelial growth factor) which is known to induce vessel leakage and which is also known to be angiogenic. In normal ... "Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis". The Journal of Clinical Investigation ... but such activity is lost with other angiogenic factors. Many angiostatic factors have been shown to counteract the effect of ...
"Inhibition of vascular endothelial growth factor in the primate ovary up-regulates hypoxia-inducible factor-1alpha in the ... It is an inhibitor of vascular endothelial growth factor (VEGF). It is used for the treatment of wet macular degeneration and ... Fraser HM, Wilson H, Silvestri A, Morris KD, Wiegand SJ (September 2008). "The role of vascular endothelial growth factor and ... Virgili G, Parravano M, Evans JR, Gordon I, Lucenteforte E (October 2018). "Anti-vascular endothelial growth factor for ...
One study suggested a possible role for vascular endothelial growth factor. A study using magnetic resonance imaging found that ... November 2005). "RS3PE syndrome presenting as vascular endothelial growth factor associated disorder". Ann. Rheum. Dis. 64 (11 ... and a negative serum rheumatoid factor. If no underlying disorder can be identified (idiopathic RS3PE), this entity has an ...
The TYMP gene is also known as ECGF1 (endothelial cell growth factor 1, platelet-derived) and MNGIE due to its role in MNGIE ... Kojima H, Shijubo N, Abe S (2002). "Thymidine phosphorylase and vascular endothelial growth factor in patients with Stage I ... 1987). "Purification and properties of an endothelial cell growth factor from human platelets". J. Biol. Chem. 262 (9): 4098- ... Identity of gliostatin and platelet-derived endothelial cell growth factor". J. Biol. Chem. 267 (28): 20311-6. PMID 1400349. ...
"Napoleone Ferrara and the saga of vascular endothelial growth factor". Endothelium. 15 (1): 1-8. doi:10.1080/10623320802092377 ... soon identified the already-known fibroblast growth factor as an angiogenic factor, but the team's work showed that there were ... In these trials they also studied the levels of fibroblast growth factor in the urine of the trial subjects and published that ... basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers". J. Natl. Cancer Inst. 86 (5): 356-61 ...
Musumeci, Francesca; Radi, Marco; Brullo, Chiara; Schenone, Silvia (25 October 2012). "Vascular Endothelial Growth Factor (VEGF ... "Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and ... platelet-derived growth factor receptor), RAF kinase, FLT3 (Fms-like tyrosine kinase-3) and KIT (stem cell factor receptor). ... Tumor types such as breast carcinoma show amplification of fibroblast growth factor related genes. Simultaneous inhibition of ...
Jeltsch, M; Karpanen, T; Strandin, T; Aho, K; Lankinen, H; Alitalo, K (28 April 2006). "Vascular endothelial growth factor ( ... "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 ( ... "Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis". The EMBO Journal. 20 (4): 672-82. ... Jeltsch was the first to show that VEGF-C and VEGF-D are the principal growth factors for the lymphatic vasculature and his ...
... can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. ... a receptor for fibroblast growth factors. Perlecan binds to growth factors involved in growth plate development. Perlecan ... Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element". J. Biol. Chem. 272 (8): ... and vascular endothelial growth factor (VEGF) families of molecules. The upstream 2.5 kilobases of the perlecan promoter region ...
Anti-vascular endothelial growth factors have been recently used for the treatment of radiation retinopathy. Monitoring of ... Radiation however, damages the endothelial cells. The management of radiation retinopathy is similar to that for diabetic ...
"Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity." Nature Medicine 10, no. 8 (2004): ...
Solomon, SD; Lindsley, K; Vedula, SS; Krzystolik, MG; Hawkins, BS (Aug 29, 2014). "Anti-vascular endothelial growth factor for ... Ranibizumab is a monoclonal antibody that inhibits angiogenesis by inhibiting vascular endothelial growth factor A, a mechanism ... "Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis". The Cochrane Database of ... "Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema following Central Retinal Vein Occlusion: 1 Initial Injection ...
Yi ZY, Feng LJ, Xiang Z, Yao H (2011). "Vascular endothelial growth factor receptor-1 activation mediates epithelial to ... homeostasis and growth, also make it susceptible to alterations that can lead to abnormal cell behavior and growth. Any changes ... These complexes, which help regulate cell growth in addition to creating and maintaining epithelial layers, are known as ... In particular, catenins have been identified to be major players in aberrant epithelial cell layer growth associated with ...
... disorder that is X-linked dominant and which causes severe mental problems sometimes associated with abnormalities of growth, ... Guanine nucleotide exchange factor. *Marinesco-Sjögren syndrome. *Aarskog-Scott syndrome. *Juvenile primary lateral sclerosis ... X-linked endothelial corneal dystrophy. Neuromuscular. *Becker's muscular dystrophy/Duchenne. *Centronuclear myopathy (MTM1) ...
It has been hypothesized that vascular endothelial growth factor may cause the vascular permeability at the root of HACE.[16] ... These factors cause the brain to swell with fluid, resulting in severe impairment.[14] If the swelling is untreated, it causes ...
2007) Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated ... The core pathology is disruption of the capillary-endothelial interface: this actually refers to two separate barriers - the ... 2007) Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated ... 2008) Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis. Am J Respir Cell Mol ...
Another agent involved in autocrine cancer signaling is vascular endothelial growth factor (VEGF). VEGF, produced by carcinoma ... Weigand, Melanie; Hantel, Pia; Kreienberg, Rolf; Waltenberger, Johannes (2005). "Autocrine vascular endothelial growth factor ... One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors. ... For example, despite widespread expression of epidermal growth factor receptors (EGFRs) and EGF family ligands in non-small- ...
The developmental morphogenesis of the canal was sensitive to the inhibition of lymphangiogenic growth factors, and in adults, ... a unique mechanism involving the transdifferentiation of venous endothelial cells in the eye into lymphatic-like endothelial ... the administration of the lymphangiogenic growth factor VEGFC enlarged the Schlemm's canal, which was associated with a ...
"Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain". J. Biol ... "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor ... Fuh G, Garcia KC, de Vos AM (2000). "The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor ... 2002). "Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.". Genes Chromosomes Cancer 33 ...
Friedman JB، Brunschwig EB، Platzer P، Wilson K، Markowitz SD (August 2004). "C8orf4 is a transforming growth factor B induced ... endothelial cell activation involved in immune response. • cellular response to heat. • regulation of DNA-templated ...
Anna Dorothea Wagner, Christoph Thomssen, Johannes Haerting, Susanne Unverzagt: Vascular-endothelial-growth-factor (VEGF) ... Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging. In: ... Vascular Endothelial Growth Factor) ein.[4]. Bevacizumab ist ein Angiogenesehemmer, der zielgerichtet an den Wachstumsfaktor ... phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor ...
growth factor). RTK. *ROR2 (Robinow syndrome). *FGFR1 (Pfeiffer syndrome, KAL2 Kallmann syndrome) ... Comparing height to standard growth charts.. *Determining the Tanner stage of sexual development. (Males with KS/CHH are ... Standard hormone replacement therapy will not normally induce fertility in either males or females, with no testicular growth ... as in cases of delayed diagnosis of KS/CHH can lead to an increased risk of developing osteoporosis but other risk factors, ...
... where they induce IFN production with the presence of a particular transcription factor and activate transcription factor 2. ... endothelial cells (via passive diffusion/ osmosis & active selection). P-glycoprotein (mechanism by which active transportation ... Neutrophil granules contain a variety of toxic substances that kill or inhibit growth of bacteria and fungi. Similar to ... Chemical factors produced during inflammation (histamine, bradykinin, serotonin, leukotrienes, and prostaglandins) sensitize ...
Mutations in TGFBI which encodes transforming growth factor beta induced cause several forms of corneal dystrophies including ... Congenital hereditary endothelial dystrophy. Treatment[edit]. Early stages may be asymptomatic and may not require any ... Congenital hereditary endothelial corneal dystrophy is characterized by a diffuse ground-glass appearance of both corneas and ... They are not caused by outside factors, such as injury or diet. ... X-linked endothelial corneal dystrophy. The following (now ...
... is a pegylated anti-vascular endothelial growth factor (VEGF) aptamer, a single strand of nucleic acid that binds ... This then reduces the growth of the blood vessels located within the eye and works to control the leakage and swelling.[2] ... Additional growth factors: Adrenomedullin. *Colony-stimulating factors (see here instead). *Connective tissue growth factor ( ... Hepatoma-derived growth factor (HDGF). *Interleukins/T-cell growth factors (see here instead) ...
Hypoxia-inducible factor-proline dioxygenase enzymes (isoforms: EGLN1, EGLN2, and EGLN3)[95][96] ... Endothelial dysfunction is implicated in many aspects of vascular diseases. The researchers noted that the effect of vitamin C ... "L-ascorbic Acid: a multifunctional molecule supporting plant growth and development". Scientifica. 2013: 1-24. doi:10.1155/ ... One of these was thought to be the anti-scorbutic factor. In 1928, this was referred to as "water-soluble C," although its ...
"Vascular endothelial growth factor B, a novel growth factor for endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2567- ... Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In ... Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)[16][17] which are ... "Vascular endothelial growth factor: A new member of the platelet-derived growth factor gene family". Biochemical and ...
Growth factor. See here instead.. Insulin. *Agonists: Chaetochromin (4548-G05). *Insulin-like growth factor 1 ... Moreover, endothelial cells have been described as a potential source for this B1 receptor-CXCL5 pathway.[11] ... Sérgio Henrique Ferreira, discovered a bradykinin-potentiating factor (BPF) in the bothropic venom, which increases powerfully ... and Tumor Growth of Gastric Cancer Through ERK Signaling Pathway". Journal of Cellular Biochemistry. 118 (12): 4444-4453. doi: ...
... although most hyaluronidase preparations are contaminated with large amounts of angiogenic growth factors.[15] ... Rahmanian M, Heldin P (February 2002). "Testicular hyaluronidase induces tubular structures of endothelial cells grown in three ... It is often speculated that Streptococcus and Staphylococcus pathogens use hyaluronidase as a virulence factor to destroy the ... "spreading factors", having a function akin to bacterial hyaluronidases.[18] ...
Clark IA (June-August 2007). "How TNF was recognized as a key mechanism of disease". Cytokine Growth Factor Rev. 18 (3-4): 335- ... negative regulation of endothelial cell proliferation. • positive regulation of heterotypic cell-cell adhesion. • negative ... TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha. ... Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) ...
... a brain-derived neurotrophic factor that function in nerve growth and maintenance within the brain.[86][20]. *Vorinostat (SAHA) ... on global DNA and neprilysin genes in murine cerebral endothelial cells". primary. Biochemical and Biophysical Research ... a neurotrophic factor important for long-term memory.[66] Expression of CREB, an activity-dependent transcription factor ... IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and ...
Virchow's triad, the classic factors which precipitate venous thrombus formation: endothelial dysfunction or injury, ... Virchow's Law, during craniosynostosis, skull growth is restricted to a plane perpendicular to the affected, prematurely fused ... He considered social factors such as poverty major causes of disease.[103] He even attacked Koch's and Ignaz Semmelweis' policy ... Related to this research, Virchow described the factors contributing to venous thrombosis, Virchow's triad.[22][58] ...
A major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in adults."[5] ... A major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in adults. ... It is believed to be a major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in ... growth factor activity. • insulin-like growth factor receptor binding. • integrin binding. • protein serine/threonine kinase ...
... or the growth of new blood vessels has been reported to correspond with MM progression where vascular endothelial growth factor ... This disrupts the positive feedback loop between the two growth factors, possibly causing both multiple birth defects and anti- ... resulting in accumulation of the ligase substrates and downregulation of fibroblast growth factor 8 (FGF8) and FGF10. ... Thalidomide was discovered to inhibit tumour necrosis factor-alpha (TNF-α) in 1991. TNF-α is a cytokine produced by macrophages ...
Newer agents such as anti Vascular Endothelial Growth Factor (anti VEGF) are also associated with similar injuries, as well as ... "Hypertension Induced by Vascular Endothelial Growth Factor Signaling Pathway Inhibition: Mechanisms and Potential Use as a ... But there is a body of evidence that several factors including apoptosis-induction seem to play a role.[17] ... In order to be a match for a kidney transplant, patients must match blood type and human leukocyte antigen factors with their ...
Hattori R, Hamilton KK, Fugate RD, McEver RP, Sims PJ (May 1989). "Stimulated secretion of endothelial von Willebrand factor is ... platelet and helps cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors ... "Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and ... In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets P-selectin is ...
... and thrombotic/mitotic growth factors, completing a vicious cycle of inflammatory changes.[9] If the process is not stopped, ... Affected arteries develop endothelial dysfunction and impairment of normal vasodilation, which alter renal autoregulation. When ... Many factors and causes are contributory in hypertensive crises. The most common cause in patients with diagnosed, chronic ... Saguner AM, Dür S, Perrig M, Schiemann U, Stuck AE, Bürgi U, Erne P, Schoenenberger AW (July 2010). "Risk factors promoting ...
Growth is enhanced by incubation in 5% CO2 atmosphere, but they usually grow adequately in ambient air. The optimum temperature ... Several virulence factors have been identified, but predominantly by screening S.dysgalactiae isolates for homologues of well- ... gfba was recently shown contribute to bacterial internalization into endothelial cells and intracellular persistence. These ... The emm-gene encodes the M-protein, a major virulence factor in both S.pyogenes and Streptococcus dysgalactiae. It is ...
Platelet-derived growth factor. *Transforming growth factor beta superfamily. *Vascular endothelial growth factor ... Additional growth factors: Adrenomedullin. *Colony-stimulating factors (see here instead). *Connective tissue growth factor ( ... Growth factors. *Epidermal growth factor. *Fibroblast growth factor. *Nerve growth factor. * ... Hepatoma-derived growth factor (HDGF). *Interleukins/T-cell growth factors (see here instead) ...
It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts ... Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. ... Nakamura T (1992). "Structure and function of hepatocyte growth factor". Progress in Growth Factor Research. 3 (1): 67-85. doi: ... "Hepatocyte Growth Factor Mediates Enhanced Wound Healing Responses and Resistance to Transforming Growth Factor-β₁-Driven ...
... vascular endothelial growth factor (VEGF), TNF, prostaglandins, leukotrienes, and varieties of chemokines and cytokines some of ... Granule contents of basophils are abundant with histamine, heparin, chondroitin sulfate, peroxidase, platelet-activating factor ...
"Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling". The Journal of Clinical ... Fibroblasts, smooth muscle cells and endothelial cells express low levels of ALOX5.[6][7] Up-regulation of ALOX5 may occur ... potent chemotactic factor, LTB4, and possibly also weaker chemotactic factor, 5S-HETE, which serve to attract and otherwise ... "Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding ...
The biology of vascular endothelial growth factor.. Ferrara N1, Davis-Smyth T. ... Vascular Endothelial Growth Factor A. *Vascular Endothelial Growth Factors. Substances. *Endothelial Growth Factors ... Endothelial Growth Factors*/chemistry. *Endothelial Growth Factors*/genetics. *Endothelial Growth Factors*/therapeutic use ... Receptors, Growth Factor. *Vascular Endothelial Growth Factor A. *Vascular Endothelial Growth Factors ...
Vascular endothelial growth factor enhances atherosclerotic plaque progression.. Celletti FL1, Waugh JM, Amabile PG, Brendolan ... Vascular endothelial growth factor (VEGF) can promote angiogenesis but may also exert certain effects to alter the rate of ... Plaque macrophage and endothelial cell content also increased disproportionately over controls. In order to confirm that the ...
... detected a stimulating activity of endothelial cells in the... ... Vascular Endothelial Growth Factor: The Cornerstone of Vascular ... Bikfalvi A. (2017) Vascular Endothelial Growth Factor: The Cornerstone of Vascular Development Factors. In: A Brief History of ... Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362(6423):841- ... Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N (1989) Vascular endothelial growth factor is a secreted angiogenic ...
... is a prime regulator of endothelial cell proliferation, angiogenesis, vasculogenesis and vascular permeability. Its activity is ... Vascular endothelial growth factor and its receptors Cytokine Growth Factor Rev. 1996 Oct;7(3):259-70. doi: 10.1016/s1359-6101( ... Vascular endothelial growth factor (VEGF) is a prime regulator of endothelial cell proliferation, angiogenesis, vasculogenesis ... Receptors, Vascular Endothelial Growth Factor * Vascular Endothelial Growth Factor A * Vascular Endothelial Growth Factors ...
Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in ... Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J Exp Med. ... Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is a homodimeric 34 to 45 ... The vascular endothelial growth factor family and its receptors. Hematol Oncol Clin North Am. 2004 Oct; 18(5):951-971,vii. ...
VEGF-A (VEGF) is a potent growth factor for blood vessel endothelial cells, showing pleiotropic responses that facilitate cell ... is a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF ... Carmeliet, P., and Collen, D., Role of vascular endothelial growth factor and vascular endothelial growth factor receptors in ... Vascular endothelial growth factor (VEGF) is a family of closely related growth factors having a conserved pattern of eight ...
Vascular endothelial growth factor (VEGF), an established angiogenesis factor, is expressed in allografts undergoing rejection ... In vitro, we found that VEGF enhanced endothelial cell expression of the chemokines monocyte chemoattractant protein 1 and IL-8 ... Anti-VEGF failed to inhibit T cell activation responses in vivo, but inhibited intragraft expression of several endothelial ... and in combination with IFN-γ synergistically induced endothelial cell production of the potent T cell chemoattractant IFN- ...
"Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and ... endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor ... "Vitreous and serum levels of vascular endothelial growth factor and platelet-derived growth factor and their correlation in ... J. W. Miller, A. P. Adamis, D. T. Shima et al., "Vascular endothelial growth factor/vascular permeability factor is temporally ...
Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor C Inhibitor, Vascular Endothelial Growth ... Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor C Inhibitor, Vascular Endothelial Growth ... Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor C Inhibitor, Vascular Endothelial Growth ... Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor Regulator. Additional Keywords : Cannabinoid ...
Endothelial Growth Factors. Mitosis Modulators. Molecular Mechanisms of Pharmacological Action. Growth Substances. ... Increased intraocular and systemic levels of the angiogenic factor vascular endothelial growth factor (VEGF) is associated with ... Vascular Endothelial Growth Factor (VEGF) in Uveitis. The safety and scientific validity of this study is the responsibility of ... This study will look for the presence in blood of a substance called vascular endothelial growth factor (VEGF) in patients with ...
Vascular endothelial growth factor (VEGF) is a cytokine that greatly increases vascular permeability and thereby promotes ... Endotoxin boosts the vascular endothelial growth factor (VEGF) in rabbits J Endotoxin Res. 2003;9(2):97-100. doi: 10.1179/ ... Vascular endothelial growth factor (VEGF) is a cytokine that greatly increases vascular permeability and thereby promotes ...
We reported that PAX6 suppresses glioblastoma cell growth in vivo and anchorage-independent growth without significant ... vascular endothelial growth factor, and epidermal growth factor receptor in gliomas: relationship to tumor grade and survival. ... Vascular endothelial growth factor A (VEGFA) is the major angiogenic factor that is overexpressed in GBM [5]. An antiangiogenic ... Because we found that PAX6 downregulates expression of the gene encoding vascular endothelial growth factor A (VEGFA) in glioma ...
We conclude that lyso-PC can induce growth factor gene expression in cultured endothelial cells and thus may contribute to the ... Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells.. ... Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells.. ... we have found that lyso-PC increased steady state mRNA levels for two smooth muscle/fibroblast-directed growth factors, the A ...
Vascular endothelial growth factor and hepatocyte growth factor levels are differentially elevated in patients with advanced ... Endothelial Growth Factors. Mitosis Modulators. Molecular Mechanisms of Pharmacological Action. Growth Substances. ... Vascular Endothelial Growth Factor in Stage V ROP. The safety and scientific validity of this study is the responsibility of ... Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol. 1996 Oct; ...
Endothelial_Growth_Factor - the Vascular Endothelial Growth Factor Structure in Interactive 3D. ... VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are ... "Transcriptional regulation of vascular endothelial growth factor in cancer". Cytokine Growth Factor Rev. 16 (1): 77-89. doi: ... Vascular endothelial growth factor-R3 has been detected in lymphatic endothelial cells in CL of many species, cattle, buffalo ...
... endothelial cell growth factor-driven endothelial tube formation is mediated by vascular endothelial cell growth factor ... Foster RR, Hole R, Anderson K, et al Functional evidence that vascular endothelial growth factor may act as an autocrine factor ... Bachelder RE, Crago A, Chung J, et al Vascular endothelial growth factor is an autocrine survival factor for neuropilin- ... Brown LF, Yeo KT, Berse B, Morgentaler A, Dvorak HF, Rosen S Vascular permeability factor (vascular endothelial growth factor) ...
Endothelial Cell Growth Factor 1 synonyms, Endothelial Cell Growth Factor 1 pronunciation, Endothelial Cell Growth Factor 1 ... English dictionary definition of Endothelial Cell Growth Factor 1. n a blast furnace outlet through which molten metal flows ... Endothelial Cell Growth Factor 1 - definition of Endothelial Cell Growth Factor 1 by The Free Dictionary https://www. ... redirected from Endothelial Cell Growth Factor 1). Also found in: Medical, Acronyms. tymp. (tɪmp) n. (Metallurgy) a blast ...
"Combined analysis of vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression in ... "Prognostic significance of serum levels of vascular endothelial growth factor and insulin-like growth factor-1 in advanced ... D. J. Park, N. J. Thomas, C. Yoon, and S. S. Yoon, "Vascular endothelial growth factor A inhibition in gastric cancer," Gastric ... Predictive Significance of Serum Level of Vascular Endothelial Growth Factor in Gastric Cancer Patients. Lu Wang, Yanli Chang, ...
Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular ... January 1998). "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and ... January 2004). "Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic ... January 2003). "Vascular endothelial growth factor-C expression in human gallbladder cancer and its relationship to lymph node ...
Comparative analysis of vascular endothelial growth factor receptors on retinal and aortic vascular endothelial cells. Diabetes ... Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 1992; 359: 843-845. ... Vascular endothelial growth factor-121 (VEGF121) is a non-heparin-binding isoform of VEGF secreted in response to hypoxic or ... Vascular endothelial growth factor-121 (VEGF121) is an angiogenic protein secreted in response to hypoxia that binds to VEGF ...
chicken chorioallantoic membrane-derived endothelial cells;. VEGF,. vascular endothelial growth factor;. PTEN,. phosphatase and ... The levels of mRNA for vascular endothelial growth factor (VEGF) are elevated in cells expressing activated PI 3-kinase or Myr- ... Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in ... Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in ...
PAVES: Pegfilgrastim Anti-vascular Endothelial Growth Factor (VEGF) Evaluation Study. The safety and scientific validity of ...
... lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the ... a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family.". Avantaggiato V., ... "Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor ... "Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor ...
... vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis ... vascular endothelial growth factor receptor 1 binding Source: GO_Central. *vascular endothelial growth factor receptor 2 ... vascular endothelial growth factor receptor 1 binding Source: GO_Central. *vascular endothelial growth factor receptor 2 ... Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, ...
Transforming growth factor {beta}1 induction of vascular endothelial growth factor receptor 1: Mechanism of pericyte-induced ... Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells ... Transforming Growth Factor-{beta} Mediates Astrocyte-Specific Regulation of Brain Endothelial Anticoagulant Factors Editorial ... Transforming Growth Factor-{beta} and Insulin-like Growth Factor Binding Protein-6, in a Calcium- and Cell Density-dependent ...
... cellular response to leukemia inhibitory factor (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling ... vascular endothelial growth factor receptor 3 binding (ortholog); INVOLVED IN angiogenesis (ortholog); animal organ ... vascular endothelial growth factor C). NCBI. Ortholog. Mus musculus (house mouse):. Vegfc (vascular endothelial growth factor C ... vascular endothelial growth factor C) HGNC Alliance Mus musculus (house mouse) : Vegfc (vascular endothelial growth factor C) ...
3 The abbreviations used are: VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; C, ... Green Tea Catechins Inhibit Vascular Endothelial Growth Factor Receptor Phosphorylation. Sylvie Lamy, Denis Gingras and Richard ... Green Tea Catechins Inhibit Vascular Endothelial Growth Factor Receptor Phosphorylation. Sylvie Lamy, Denis Gingras and Richard ... Green Tea Catechins Inhibit Vascular Endothelial Growth Factor Receptor Phosphorylation. Sylvie Lamy, Denis Gingras and Richard ...
Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) genes to human chromosome 6p12-p21 ... Free insulin growth factor-1 and vascular endothelial growth factor in the vitreous fluid of patients with proliferative ... Vascular Endothelial Growth Factor; VEGF. http://www.lymphedemapeople/thesite/vascular_endothelial_growth_factor_VEGF.htm. VEGF ... Overproduction of vascular endothelial growth factor/vascular permeability factor is causative in Crow-Fukase (POEMS) syndrome ...
... the main regulator for the cell membrane tight junction is vascular endothelial growth factor (VEGF). This is produced by the ... Retrieved from "http://drmyhill.co.uk/drmyhill/index.php?title=Vascular_endothelial_growth_factor_(VEGF)-_salivary_test_for_ ...
... J Biol Chem. 261(4):1924-8. ...
  • Vascular endothelial growth factor (VEGF) is a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. (sigmaaldrich.com)
  • VEGF-A (VEGF) is a potent growth factor for blood vessel endothelial cells, showing pleiotropic responses that facilitate cell migration, proliferation, tube formation, and survival. (sigmaaldrich.com)
  • It is also one of the most potent permeability factors, so that VEGF-A is a common link of inflammation, permeability and angiogenesis. (sigmaaldrich.com)
  • Local hypoxia is a potent inducer of VEGF-A expression from adjacent cells but it is not synthesized in endothelial cells, indicating a paracrine regulation of vessel formation. (sigmaaldrich.com)
  • VEGF-B exerts its actions through one receptor (VEGFR-1).VEGF-C, also called VEGF-related factor (VRP) or VEGF-2, in the adult is expressed primarily in the heart, placenta, lung, kidney, muscle, ovary and small intestine. (sigmaaldrich.com)
  • VEGF-D, also called c-fos induced growth factor (FIGF), is a VEGF homologue induced by c-fos. (sigmaaldrich.com)
  • Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). (sigmaaldrich.com)
  • Vascular endothelial growth factor (VEGF) and its receptors. (sigmaaldrich.com)
  • Vascular endothelial growth factor (VEGF) can promote angiogenesis but may also exert certain effects to alter the rate of atherosclerotic plaque development. (nih.gov)
  • Vascular endothelial growth factor (VEGF) is a prime regulator of endothelial cell proliferation, angiogenesis, vasculogenesis and vascular permeability. (nih.gov)
  • Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is a homodimeric 34 to 45 kilodalton, heparin-binding glycoprotein. (labcorp.com)
  • VEGF has potent angiogenic, mitogenic, and vascular permeability-enhancing activities specific for endothelial cells. (labcorp.com)
  • 1 Tumor expression of proangiogenic factors, including VEGF, has been associated with advanced tumor progression in a number of human cancers. (labcorp.com)
  • 23 It has been hypothesized that VEGF released from activated platelets may have a role in angiogenesis during wound healing and may also be associated with pathological conditions, such as atherosclerosis, tumor growth, and metastasis formation. (labcorp.com)
  • The vascular endothelial growth factor (VEGF) family of growth factors controls pathological angiogenesis and increased vascular permeability in important eye diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD). (nih.gov)
  • When we focus on the VEGF receptors, recent findings suggest a role of VEGFR-1 as a functional receptor for placenta growth factor (PlGF) and vascular endothelial growth factor-A (VEGF)-A in pericytes and vascular smooth muscle cells in vivo rather than in endothelial cells, and strongly suggest involvement of pericytes in early phases of angiogenesis. (nih.gov)
  • Vascular endothelial growth factor (VEGF), an established angiogenesis factor, is expressed in allografts undergoing rejection, but its function in the rejection process has not been defined. (jci.org)
  • In vitro, we found that VEGF enhanced endothelial cell expression of the chemokines monocyte chemoattractant protein 1 and IL-8, and in combination with IFN-γ synergistically induced endothelial cell production of the potent T cell chemoattractant IFN-inducible protein-10 (IP-10). (jci.org)
  • Anti-VEGF failed to inhibit T cell activation responses in vivo, but inhibited intragraft expression of several endothelial cell adhesion molecules and chemokines, including IP-10. (jci.org)
  • Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells," Proceedings of the National Academy of Sciences of the United States of America , vol. 95, no. 20, pp. 11709-11714, 1998. (hindawi.com)
  • Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization," Investigative Ophthalmology and Visual Science , vol. 44, no. 7, pp. 3186-3193, 2003. (hindawi.com)
  • This study will look for the presence in blood of a substance called vascular endothelial growth factor (VEGF) in patients with uveitis (eye inflammation). (clinicaltrials.gov)
  • Increased intraocular and systemic levels of the angiogenic factor vascular endothelial growth factor (VEGF) is associated with new vessel growth in the eye, such as diabetic retinopathy. (clinicaltrials.gov)
  • Vascular Endothelial Growth Factor (VEGF) is a dimeric glycoprotein, naturally expressed in epithelial and tumor cells (1). (clinicaltrials.gov)
  • Growth of new blood vessels (angiogenesis), required for all tumor growth, is stimulated by the expression of vascular endothelial growth factor (VEGF). (aacrjournals.org)
  • Finally, we show that VEGF 165 b expressing tumors grow significantly more slowly than VEGF 165 -expressing tumors, indicating that a switch in splicing from VEGF 165 to VEGF 165 b can inhibit tumor growth. (aacrjournals.org)
  • Angiogenesis is stimulated by the expression of vascular growth factors, the most commonly expressed of which is vascular endothelial growth factor (VEGF). (aacrjournals.org)
  • Of all of the growth factors involved in angiogenesis, VEGF appears to play an irreplaceable role. (aacrjournals.org)
  • VEGF was originally described as a growth and survival factor for endothelial cells. (aacrjournals.org)
  • Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF), is a signal protein produced by fibroblasts that stimulates the formation of blood vessels. (wikipedia.org)
  • To be specific, VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. (wikipedia.org)
  • In 1989 Ferrara and Henzel described an identical factor in bovine pituitary follicular cells which they purified, cloned and named VEGF. (wikipedia.org)
  • In vitro, VEGF-A has been shown to stimulate endothelial cell mitogenesis and cell migration. (wikipedia.org)
  • VEGF-A is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor. (wikipedia.org)
  • Role of vascular endothelial growth factor (VEGF) and VEGF-R genotyping in guiding the metastatic process in pT4a resected gastric cancer patients," PLoS ONE , vol. 7, no. 7, Article ID e38192, 2012. (hindawi.com)
  • Vascular endothelial growth factor-121 (VEGF 121 ) is an angiogenic protein secreted in response to hypoxia that binds to VEGF receptors overexpressed by ischemic microvasculature. (ahajournals.org)
  • Vascular endothelial growth factor-121 (VEGF 121 ) is a non-heparin-binding isoform of VEGF secreted in response to hypoxic or ischemic conditions. (ahajournals.org)
  • Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family. (wikipedia.org)
  • The main function of VEGF-C is to promote the growth of lymphatic vessels (lymphangiogenesis). (wikipedia.org)
  • In invertebrates, molecules from this families are not easily distinguished from each other and are collectively referred to as PVFs (PDGF/VEGF-like growth factors. (wikipedia.org)
  • The levels of mRNA for vascular endothelial growth factor (VEGF) are elevated in cells expressing activated PI 3-kinase or Myr-Akt. (pnas.org)
  • The present study demonstrates that Cr(VI) induces hypoxia-inducible factor 1 (HIF-1) activity through the specific expression of HIF-1alpha but not HIF-1beta subunit and increases the level of vascular endothelial growth factor (VEGF) expression in DU145 human prostate carcinoma cells. (cdc.gov)
  • Vascular Endothelial Growth Factor B (VEGF Related Factor or VEGFB) - Vascular endothelial growth factor B also known as VEGF-B is a protein encoded by the VEGF-B gene. (researchandmarkets.com)
  • Vascular Endothelial Growth Factor B (VEGF Related Factor or VEGFB) pipeline Target constitutes close to 15 molecules. (researchandmarkets.com)
  • The latest report Vascular Endothelial Growth Factor B - Pipeline Review, H1 2020, outlays comprehensive information on the Vascular Endothelial Growth Factor B (VEGF Related Factor or VEGFB) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (researchandmarkets.com)
  • It also reviews key players involved in Vascular Endothelial Growth Factor B (VEGF Related Factor or VEGFB) targeted therapeutics development with respective active and dormant or discontinued projects. (researchandmarkets.com)
  • Objective To investigate the relation of circulating concentrations of vascular endothelial growth factor (VEGF) for the risk of developing cardiovascular disease (CVD) in a large community-based sample. (bmj.com)
  • Multivariable Cox proportional hazards models were estimated adjusting for standard risk factors to VEGF quartiles to incident CVD. (bmj.com)
  • Vascular endothelial growth factor (VEGF) receptors (VEGFR) play a major role in tumor angiogenesis and, thus, represent attractive targets for the development of novel anticancer therapeutics. (aacrjournals.org)
  • VEGF 3 is an endothelial cell-specific mitogen that is often associated with tumor-induced angiogenesis. (aacrjournals.org)
  • demonstrated that VEGF, also called vascular permeability factor (VPF), is produced by cultured vascular smooth muscle cells. (lymphedemapeople.com)
  • Ferrara and Henzel (1989) determined that purified bovine Vegf was mitogenic to adrenal cortex-derived capillary endothelial cells and to several other vascular endothelial cells, but it was not mitogenic toward nonendothelial cells. (lymphedemapeople.com)
  • demonstrated that culture media conditioned by human embryonic kidney cells expressing either bovine or human VEGF cDNA promoted proliferation of capillary endothelial cells. (lymphedemapeople.com)
  • VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. (lymphedemapeople.com)
  • Folkman (1995) noted the importance of VEGF and its receptor system in tumor growth and suggested that intervention in this system may provide promising approaches to cancer therapy. (lymphedemapeople.com)
  • VEGF and placental growth factor ( 601121 ) constitute a family of regulatory peptides capable of controlling blood vessel formation and permeability by interacting with 2 endothelial tyrosine kinase receptors, FLT1 ( 165070 ) and KDR/FLK1. (lymphedemapeople.com)
  • Because this is extremely hard work and the body does not want to waste energy, the main regulator for the cell membrane tight junction is vascular endothelial growth factor (VEGF). (drmyhill.co.uk)
  • Vascular endothelial growth factor (VEGF) plays an important role in many disease states, including ischemia, chronic and acute inflammation, and pathologies associated with angiogenesis such as tumors and wounds. (spandidos-publications.com)
  • A number of factors regulate VEGF promoter activity and VEGF expression such as four and a half LIM domains 1 (FHL1) and Smad4. (spandidos-publications.com)
  • The role of vascular endothelial growth factor (VEGF) in the regulation of angiogenesis has been under investigation for over a decade ( 1 ). (spandidos-publications.com)
  • The VEGF family includes VEGF-A, VEGF-B, VEGF-C, VEGF-D and placental growth factor (PlGF) in mammals ( 2 , 3 ), as well as two exogenous VEGF subtypes, VEGF-E (virus genome-encoded VEGF) and VEGF-F (snake venom-derived VEGF) ( 4 , 5 ). (spandidos-publications.com)
  • These VEGF molecules act through binding to several high-affinity transmembrane endothelial cell receptors, including Flt-1 (VEGFR1), KDR (VEGFR2) and Flt-4 (VEGFR3) with varying specificities. (spandidos-publications.com)
  • Binding of VEGF to these receptors leads to intracellular receptor phosphorylation which initiates various intracellular downstream receptor pathways, leading to endothelial cell proliferation and blood vessel formation. (spandidos-publications.com)
  • Vascular endothelial growth factor A (VEGF A) protein molecule. (sciencephoto.com)
  • Vascular endothelial growth factor (VEGF)/vascular permeability factor is the prototype for a growing family of dimeric growth factors, which exert their effects on vascular and lymphatic endothelial cells, as well as on a wide range of other cell types. (portlandpress.com)
  • Growing tumours produce VEGF, and many different strategies for inhibiting tumour growth by inhibiting VEGF production are being tested in clinical trials at present. (portlandpress.com)
  • It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR D in that they both contain N- and C-terminal extensions that were not found in other VEGF family members. (curehunter.com)
  • Vascular endothelial growth factor (VEGF) is well known to play an important regulatory role in vascular growth and development. (jneurosci.org)
  • We applied VEGF to normoxic fetal organotypic cortical explants as a model of CNS neuropil, in addition to primary cortical neurons, to assess direct growth effects absent vascular or astroglial activity. (jneurosci.org)
  • Antisense oligodeoxynucleotides to flk-1 , but not flt-1 , inhibited neuritic outgrowth, whereas inhibitors of the signaling pathways MEK1 and P13-AKT both abrogated VEGF-induced growth. (jneurosci.org)
  • Possibly, VEGF achieves its effects by acting on the neuronal microtubular content, which is involved with growth, stability and maturation. (jneurosci.org)
  • Vascular endothelial growth factor (VEGF) is a secreted vascular mitogen that is purportedly specific for endothelial cells and plays an important regulatory role in vascular growth in several organ systems during development ( Ferrara and Davis-Smyth, 1997 ). (jneurosci.org)
  • Little information exists concerning the direct growth effects of the application of VEGF to CNS tissue because most work regarding VEGF action, receptor mechanisms, and signaling pathways has been done in non-neural tissues. (jneurosci.org)
  • Thus, precise growth and developmental roles for VEGF in CNS tissue are difficult to determine, particularly because the protein is markedly downregulated after birth. (jneurosci.org)
  • In the present study we have examined the neurotrophic actions of VEGF on fetal cortical explants as well as on primary cortical neurons to further assess how VEGF may directly affect neuronal growth absent any angiogenic or astroglial activity. (jneurosci.org)
  • Here, we show that vascular endothelial growth factor (VEGF) signaling profoundly affects both vascularization and innervation of the pancreatic islet. (biologists.org)
  • Using genetic mouse models, we demonstrate that VEGF regulates islet innervation indirectly through its effects on intra-islet endothelial cells. (biologists.org)
  • VEGF111 is a recently described vascular endothelial growth factor (VEGF) isoform that does not bind to the extracellular matrix, diffuses extensively, and is resistant to proteolysis. (biomedsearch.com)
  • Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF, VEGF-A) is a multifunctional cytokine with important roles in pathological angiogenesis. (rupress.org)
  • Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF, VEGF-A) * is a multifunctional cytokine that has essential roles in both processes ( 5 - 8 ). (rupress.org)
  • Another member of the VPF/VEGF family, placenta growth factor (PlGF), also has a role in pathological angiogenesis, interacting with VEGFR-1 but not VEGFR-2 ( 9 ). (rupress.org)
  • The central molecule that directs proliferation and migration of LECs during embryogenesis is vascular endothelial growth factor C (VEGF-C). VEGF-C is therefore an important ingredient for LEC culture and attempts to (re)generate lymphatic vessels and networks. (frontiersin.org)
  • In this review, we discuss the molecular biology of VEGF-C as it relates to the growth of LECs and lymphatic vessels. (frontiersin.org)
  • The central growth factor that mediates these tasks is vascular endothelial growth factor C (VEGF-C). While being a member of the VEGF family of growth factors, VEGF-C is in many aspects very different from the vascular endothelial growth factor prototype VEGF-A. (frontiersin.org)
  • Vascular endothelial growth factor (VEGF) induces both angiogenesis and an increase in vascular permeability, 2 processes that are considered to be important for both tumor growth and the delivery of drugs to the site of tumors. (bloodjournal.org)
  • It is further shown that tmTNF is required for VEGF-mediated endothelial hyperpermeability in vitro and in vivo. (bloodjournal.org)
  • This permissive activity of TNF appears to be selective, because anti-TNF antibodies ablated the VEGF-induced permeability but not proliferation of cultivated human endothelial cells. (bloodjournal.org)
  • Subsequent studies indicated that the tmTNF and VEGF signaling pathways converge at the level of a secondary messenger, the "stress-activated protein kinase-2" (SAPK-2)/p38: (1) up-regulated endothelial expression of tmTNF resulted in the continuous activation of SAPK-2/p38 in vitro, and (2) an inhibitor of SAPK-2/p38 activation abolished the vascular permeability activity of VEGF in vivo. (bloodjournal.org)
  • In conclusion, the study's finding that continuous autocrine signaling by tmTNF sensitizes endothelial cells to respond to VEGF by increasing their vascular permeability provides new therapeutic concepts for manipulating vascular hyperpermeability. (bloodjournal.org)
  • Vascular endothelial growth factor (VEGF) is essential for both vasculogenesis and angiogenesis 1 but was first identified as a tumor-produced vascular permeability factor (VPF) because of its potent activity in the Miles assay of vascular permeability. (bloodjournal.org)
  • 5-7 In animal experiments it has been shown that the rapid induction of VEGF-mediated vascular permeability correlates with the formation of endothelial vesiculovacuolar organelles (VVOs) and fenestrations. (bloodjournal.org)
  • We also show that neutralization of TNF ablates vascular permeability, induced by VEGF in endothelial cells, in vitro and in vivo, which suggests that the ability of VEGF to induce vascular permeability is facilitated by endogenously expressed TNF. (bloodjournal.org)
  • Vascular endothelial growth factor (VEGF) plays an important role in homeostasis and diseases of the retinal pigment epithelium (RPE), choriocapillaris, and, most notably, age-related macular degeneration (AMD). (molvis.org)
  • Vascular endothelial growth factor (VEGF) was purified from media conditioned by bovine pituitary folliculostellate cells (FC). (sciencemag.org)
  • VEGF is a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo. (sciencemag.org)
  • Human 293 cells transfected with an expression vector containing a bovine or human VEGF cDNA insert secrete an endothelial cell mitogen that behaves like native VEGF. (sciencemag.org)
  • Retinal vascular endothelial growth factor (VEGF) increased by neovascularization is well known as a pathogenic factor in ocular neovascular diseases. (mdpi.com)
  • VEGF-induced degradation of limiting membrane and translocation of nuclear factor kappa B (NF-κB) were analyzed by immunocytochemistry. (mdpi.com)
  • We intended to delineate the mechanisms of erythropoietin (EPO)-induced cardiac vascular endothelial growth factor (VEGF) production and to establish if VEGF is crucial for EPO-induced improvement of cardiac performance. (rug.nl)
  • EPO stimulated VEGF mRNA expression through the signal transducers and activators of transcription-3 (STAT-3) pathway in neonatal rat cardiomyocytes, but not in endothelial cells or fibroblasts. (rug.nl)
  • Similarly, the direct effects of EPO on endothelial sprouting were modest and VEGF independent. (rug.nl)
  • VEGF neutralization attenuated EPO-induced proliferation of myocardial endothelial cells and reduced myocardial incorporation of endothelial progenitor cells (EPCs) in rats with alkaline phosphatase-labelled bone marrow cells. (rug.nl)
  • EPO fosters VEGF expression predominantly in cardiomyocytes, which in turn stimulates myocardial endothelial proliferation and incorporation of EPCs. (rug.nl)
  • Vascular endothelial growth factor (VEGF) plays a neuroprotective role in mice harboring mutations of copper-zinc superoxide dismutase 1 (SOD1) in familial amyotrophic lateral sclerosis (ALS). (jneurosci.org)
  • We postulate that the resultant dysregulation of VEGF posttranscriptional processing critically reduces the level of this neuroprotective growth factor and accelerates the neurodegenerative process in ALS. (jneurosci.org)
  • Vascular endothelial growth factor (VEGF) is considered a key mediator of tumor angiogenesis, including neovascularization in human breast cancer. (diva-portal.org)
  • In this thesis we have investigated the effects of estradiol, progesterone, and the nonsteroidal anti-estrogen tamoxifen on vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1 and VEGFR-2) in normal human breast tissue, endothelial cells, and breast cancer. (diva-portal.org)
  • Conclusions- Mobilization of endothelial progenitor cells with cytokines potentiates VEGF-2 gene therapy for myocardial ischemia and enhances bone marrow cell incorporation into ischemic myocardium. (ahajournals.org)
  • Catheter-based, intramyocardial vascular endothelial growth factor (VEGF) gene transfer has been shown to induce therapeutic angiogenesis in preclinical models of myocardial ischemia 1,2 and to increase exercise tolerance time and decrease the incidence of anginal episodes in pilot studies in patients with chronic myocardial ischemia. (ahajournals.org)
  • 9,10 Recent clinical data have revealed that VEGF gene transfer is also accompanied by the mobilization of BM-derived endothelial progenitor cells (EPCs). (ahajournals.org)
  • This test measures the amount of vascular endothelial growth factor (VEGF) in your blood. (brighamandwomens.org)
  • VEGF is a substance that helps encourage the growth of new blood vessels. (brighamandwomens.org)
  • But VEGF also plays a role in cancer growth. (brighamandwomens.org)
  • Vascular endothelial growth factor (VEGF) is a potent inducer of endothelial cell growth and angiogenesis. (ovid.com)
  • The study addressed the role for aldose reductase (AR) in 1 ) retinal oxidative stress and vascular endothelial growth factor (VEGF) overexpression in early diabetes, and 2 ) high glucose-induced oxidative stress in retinal endothelial cells. (diabetesjournals.org)
  • Furthermore, our earlier ARI study in long-term galactose-fed rats ( 2 ) and a more recent antioxidant study in short-term diabetic rats ( 17 ) revealed the capacity of both classes of agents to prevent increased expression of retinal vascular endothelial growth factor (VEGF). (diabetesjournals.org)
  • Vascular endothelial growth factor (VEGF) is one such potent angiogenic factor. (spandidos-publications.com)
  • Factors involved in the control of VEGF production by glioma cells are not well known. (spandidos-publications.com)
  • In this study, we investigated the role of basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), and platelet derived growth factors (PDGF) on VEGF production by four different glioma cell lines in vitro. (spandidos-publications.com)
  • With the exception of PDGF A/A and B/B in one cell line, all growth factors differentially stimulated VEGF production in all cell lines investigated. (spandidos-publications.com)
  • These data suggest that VEGF production in human glioma may be regulated by other growth factors which are also known to be expressed in such tumours. (spandidos-publications.com)
  • To explore the in vivo anti-angiogenesis effects resulting from lentivirus-mediated RNAi of vascular endothelial growth factor (VEGF) in monkeys with iris neovascularization (INV). (molvis.org)
  • A gene on chromosome 5q35.3 that encodes a tyrosine kinase receptor for vascular endothelial growth factors (VEGF) C and D, which appear to play a role in lymphangiogenesis and maintenance of the lymphatic endothelium. (thefreedictionary.com)
  • Angiogenesis is critical to tumor growth and metastasis and is dependent on growth factors, such as vascular endothelial growth factor (VEGF). (eurekaselect.com)
  • The most characterized angiogenic factor, VEGF is an endothelial cell mitogen and permeability factor that has been found to be overexpressed in almost all human cancers. (eurekaselect.com)
  • In a number of tumor model systems, antagonism of the VEGF pathway results in inhibition of angiogenesis and tumor growth. (eurekaselect.com)
  • Specifically, VEGF inhibition has been shown to suppress tumor growth, decrease microvasculature, and induce apoptosis of endothelial cells. (eurekaselect.com)
  • This close relationship between hypoxia, angiogenesis, and tumor growth makes VEGF and VEGF receptors attractive targets for anti-neoplastic therapies. (eurekaselect.com)
  • AIMS/BACKGROUND: Vascular endothelial growth factor (VEGF) is a hypoxia induced angiogenic factor. (bmj.com)
  • Thus, VEGF may function as a linking factor between retinal ischaemia and PDR associated neovascularisation. (bmj.com)
  • The article discusses a research that suggests that choroidal neovascularization and retinal exudation in patients with choroidal osteoma can be regulated with anti-vascular endothelial growth factor (VEGF) therapy. (ebscohost.com)
  • The article discusses a research study which showed the effectiveness of anti-vascular endothelial growth factor (VEGF) therapy in the treatment of patients with myopic choroidal neovascularization (CNV). (ebscohost.com)
  • The article focuses on the study on anti-vascular endothelial growth factor (anti-VEGF) as treatment option for other retinal diseases. (ebscohost.com)
  • The article features the study made by Dr. Scott Cousins on the efficacy of E10030 anti-platelet-derived growth factor (PDGF) from Ophthotech Corp. and Lucentis anti-vascular endothelial growth factor (VEGF) agent from Genentech Inc. in Fort Lauderdale, Florida. (ebscohost.com)
  • The article discusses the role of anti-vascular endothelial growth factor (VEGF) therapy in treatment of corneal neovascularization. (ebscohost.com)
  • Vascular endothelial growth factor (VEGF) is a potent stimulatory factor of angiogenesis and a negative prognostic indicator of breast cancer. (diva-portal.org)
  • The aim of the present study was to evaluate the effect of GnRH analogues on the in-vitro eutopic endometrial cell apoptosis and release of interleukin-1beta (IL-1beta) and vascular endothelial growth factor (VEGF). (unboundmedicine.com)
  • To understand the pathogenetic mechanisms of endometriosis by examining the expression of adhesion molecules (CD44s), angiogenic factor (VEGF) and matrix protease and to perform Ki-67 labeling for evaluation of proliferative activity. (unboundmedicine.com)
  • CRH increased cAMP and induced secretion of vascular endothelial growth factor (VEGF) without tryptase, histamine, IL-6, IL-8, or TNF-α release. (jimmunol.org)
  • A transnational collaborative network dedicated to the study and applications of the vascular endothelial growth factor-A in medical practice: the VEGF Consortium" Clinical Chemistry and Laboratory Medicine (CCLM) , vol. 56, no. 4, 2018, pp. 83-86. (degruyter.com)
  • Vascular endothelial growth factor (VEGF) targeted therapy has reported success in a small number of APT case reports. (frontiersin.org)
  • Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. (ajtmh.org)
  • We carefully examine the regulating mechanisms of vascular endothelial growth factor (VEGF) and angiopoietins (Ang1 and Ang2) on the proliferation, migration and maturation of endothelial cells through their endothelium-specific receptor tyrosine kinase VEGFR2 and Tie2, respectively. (aimsciences.org)
  • We have previously shown in vitro that vascular endothelial growth factor (VEGF), produced by almost all tumors, is one of the tumor-derived factors responsible for the defective function of these cells. (bloodjournal.org)
  • Infusion of VEGF was associated with inhibition of the activity of the transcription factor NF-κB in bone marrow progenitor cells. (bloodjournal.org)
  • Experiments in vitro showed that VEGF itself, and not factors released by VEGF-activated endothelial cells, affected polypotent stem cells resulting in the observed abnormal hematopoiesis. (bloodjournal.org)
  • 9-11 Several soluble factors have been implicated in defective DC maturation in cancer, including vascular endothelial growth factor (VEGF). (bloodjournal.org)
  • 12 13 VEGF stimulates the proliferation of endothelial cells and plays an important role in the formation of tumor neovasculature. (bloodjournal.org)
  • 8 VEGF binds to hematopoietic progenitor CD34 + cells through one of the VEGF-specific receptors (Flt-1) and inhibits the activation of transcription factor NF-κB in these cells. (bloodjournal.org)
  • We ask in this study whether recombinant VEGF alone at relevant concentrations would cause significant alterations in DC development in vivo in otherwise healthy animals, which cell populations would be most affected, and what role other factors may play in the effects mediated by VEGF. (bloodjournal.org)
  • It was recently shown that vascular endothelial growth factor (VEGF), a growth factor for endothelial cells, plays a pivotal role in rheumatoid arthritis. (jimmunol.org)
  • These results show that VEGF is a key factor in pannus development, acting through the VEGF-RI pathway. (jimmunol.org)
  • It was recently demonstrated that vascular endothelial growth factor (VEGF) plays a pivotal role in RA ( 1 , 2 , 3 ). (jimmunol.org)
  • VEGF is a growth factor for endothelial cells, it also increases vascular permeability. (jimmunol.org)
  • Vascular endothelial growth factor (VEGF) is expressed in both tumor and stromal cells in gastric cancer. (karger.com)
  • Our aim was to study the prognostic effect of LDH5, and tumoral and stromal expression of the angiogenic factor VEGF in gastric cancer, and the intercorrelation of tissue expression of both factors. (karger.com)
  • The results of our study showed that high LDH5 and VEGF expression in both tumor and stroma was a prognostic factor for patients with gastric cancers, especially diffuse- or mixed-type cancers. (karger.com)
  • Aerobic glycolysis has been shown to be under the direct control of hypoxia-inducible factors (HIF-1α and 2α) in the transcription of a variety of genes involved in angiogenesis, glycolysis, and apoptosis, including vascular endothelial growth factor (VEGF) and LDHA [ 8 ]. (karger.com)
  • The effect of vascular endothelial growth factor (VEGF) on skin flap survival and its ability to induce a pharmacological delay by promoting angiogenesis in a flap was studied in a rat transverse rectus abdominis musculocutaneous flap, using a 3 x 8-cm skin paddle with the inferior epigastric vessels as its main vascular supply. (biomedsearch.com)
  • We have recently observed lower levels of vascular endothelial growth factor (VEGF) in ovarian cancer patients with greater social support, whereas higher VEGF was found in patients with greater distress. (aacrjournals.org)
  • VEGF is primarily produced by tumor cells, endothelial cells, and platelets (11 , 12 , 13 , 14) , and works by stimulating endothelial cells in microvessels to proliferate, migrate, and alter their pattern of gene expression. (aacrjournals.org)
  • This suggests that angiogenesis is an important mediator of the behaviour of breast tumours.A protein called vascular endothelial growth factor (VEGF) has been described which is a potent inducer of angiogenesis. (gla.ac.uk)
  • It is a specific endothelial mitogen produced by both normal tissues and tumours.Prior to commencement of this thesis the role of VEGF in breast cancer had not been reported. (gla.ac.uk)
  • Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis and vascular permeability. (aacrjournals.org)
  • VEGF, also known as vascular permeability factor, is a unique angiogenic dimeric glycoprotein with a molecular mass of 34-42 kDa. (aacrjournals.org)
  • We used a tetracycline-regulated transgenic system to test whether the induction of vascular endothelial growth factor (VEGF) in the germinal matrix leads to intracranial hemorrhage. (sciencemag.org)
  • Vascular endothelial growth factor D (VEGF-D) is a ligand for VEGF receptor 2 (VEGFR-2) and for VEGFR-3, which are predominantly expressed on blood vascular endothelial cells and on lymphatic endothelial cells, respectively. (helsinki.fi)
  • Thus VEGF-D can contribute to growth of both blood vessels (angiogenesis) and lymphatic vessels (lymphangiogenesis). (helsinki.fi)
  • The goal of this study was to produce and purify high quality biologically active VEGF-D which is needed for studying the physiological role of this growth factor. (helsinki.fi)
  • The (P)RR-mediated dual activation of tissue RAS and RAS-independent signalling pathways, referred to as the receptor-associated prorenin system (RAPS), was shown to facilitate vascular endothelial growth factor (VEGF)-driven pathogenesis of non-proliferative DR in mice. (bmj.com)
  • We further reported that the intravitreal levels of soluble form of (P)RR (s(P)RR), released from neovascular endothelial cells in fibrovascular tissues, increased in the patients with proliferative DR (PDR) and correlated with vitreous prorenin and VEGF levels. (bmj.com)
  • Vascular endothelial growth factor (VEGF) promotes vascular permeability (VP) and neovascularization, and is required for development. (rupress.org)
  • In cultured endothelial cells, VEGF, but not basic fibroblast growth factor, promotes the Src-mediated phosphorylation of FAK on tyrosine 861, which contributes to the formation of a FAK/αvβ5 signaling complex. (rupress.org)
  • To investigate the mechanism by which the VEGF pathway coordinates with integrin αvβ5 and Src kinase, an in vivo angiogenesis model was used with a defined growth factor input, (i.e. (rupress.org)
  • Blocking or inhibiting VEGF helps prevent further growth of the blood vessels that the cancer needs to continue growing. (natmedtalk.com)
  • The activation of adenosine receptors results in the synthesis of HIF-1 and VEGF, proteins critically important for the growth and stability of cancer cells. (natmedtalk.com)
  • VEGF, as we know, stimulates the growth of blood vessels into tissues. (natmedtalk.com)
  • Although hypoxia stimulates the synthesis and release of VEGF, adenosine stimulates the synthesis and release of BOTH VEGF and IL-8, another powerful angiogenesis factor. (natmedtalk.com)
  • To test the hypothesis that 20-HETE increases endothelial cell (EC) proliferation via vascular endothelial growth factor (VEGF), we studied the effects of WIT003 [20-hydroxyeicosa-5( Z ),14( Z )-dienoic acid], a 20-HETE analog on human macrovascular or microvascular EC. (aspetjournals.org)
  • In normal tissues, blood vessel growth is regulated through a complex balance between the actions of proangiogenic factors [e.g., vascular endothelial growth factor (VEGF)] and angiogenic inhibitors. (aspetjournals.org)
  • VEGF is a crucial factor in the regulation of angiogenesis. (aspetjournals.org)
  • VEGF expression is regulated by a number of external factors. (aspetjournals.org)
  • Vessel formation as well as the levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) were decreased at the damaged site in tPA −/− mice. (physiology.org)
  • The fibrinolytic system activates the tissue proteolytic system and modulates the release of growth factors from extracellular matrix, such as vascular endothelial growth factor (VEGF) ( 22 , 31 ). (physiology.org)
  • We hypothesized that vascular endothelial growth factor (VEGF) released from a coil promotes clot organization, hyperplasia, and endothelial proliferation to facilitate closure of the aneurysm neck. (ajnr.org)
  • Vascular endothelial growth factor (VEGF) is a heparin-binding glycoprotein that also functions as a vascular permeability factor (8, 9) . (ajnr.org)
  • VEGF is produced by macrophages, endothelial cells, and smooth muscle cells (9) and is currently under intense investigation for its therapeutic effectiveness in elevating collateral flow in areas of myocardial ischemia. (ajnr.org)
  • Therefore, an angiogenesis-promoting factor such as VEGF may enhance fibrosis and subsequent aneurysm obliteration in a similar hemodynamic environment. (ajnr.org)
  • The vascular endothelial growth factor (VEGF) receptor-1 (VEGFR-1) is a tyrosine kinase receptor that does not play a relevant role in physiologic angiogenesis in adults, whereas it is important in tumor angiogenesis. (aspetjournals.org)
  • The mAb is able to inhibit chemotaxis and extracellular matrix invasion of glioma cells in vitro stimulated by VEGF-A and by the VEGFR-1-selective ligand placental growth factor (PlGF). (aspetjournals.org)
  • Vascular endothelial growth factor (VEGF) is a potent endothelial mitogen that results in angiogenesis when overexpressed in human subjects. (portlandpress.com)
  • 1-5 Authors: Sengul Samanci N, Poturoglu S, Samanci C, Ustabasioglu FE, Koldas M, Duman AE, Ormeci AC Abstract Background: We evaluated ocular hemodynamic changes, malondialdehyde(MDA) and vascular endothelial growth factor (VEGF) levels in patients with IBD.Methods: We used ocular color Doppler ultrasonography to analyze 56 eyes with Crohn's disease (CD), 62 eyes with ulcerative colitis (UC), 68 eyes of healthy volunteers. (medworm.com)
  • Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) have been strongly implicated in the growth and metastasis of gastric cancer. (aacrjournals.org)
  • The purpose of this study was to examine the effects of ZD6474, an inhibitor of inhibitor of VEGF receptor (VEGFR) tyrosine kinase with additional activity against EGF receptor (EGFR), on tumor growth and angiogenesis in an orthotopic model of gastric cancer. (aacrjournals.org)
  • In addition, VEGF-mediated activation of VEGFR2 and Erk-1/2 was decreased in human umbilical vascular endothelial cells. (aacrjournals.org)
  • The roles of vascular endothelial growth factor (VEGF) and its receptors as important mediators in endothelial cell proliferation, migration, invasion, and differentiation during angiogenesis have been well established ( 4 ). (aacrjournals.org)
  • The authors evaluated the neuroprotective and angiogenic effects of a continuous and low-dose infusion of vascular endothelial growth factor (VEGF)-165 on cerebral ischemia in rats. (thejns.org)
  • It has been shown that expression of the potent angiogenic factor, vascular endothelial growth factor (VEGF), and its receptors, flt-1 (VEGFR-1) and KDR/Flk-1 (VEGFR-2), increased during the development of liver fibrosis. (bmj.com)
  • Our in vitro study showed that VEGF treatment significantly stimulated proliferation of both activated hepatic stellate cells (HSC) and sinusoidal endothelial cells (SEC). VEGF also significantly increased α1(I)-procollagen mRNA expression in activated HSC. (bmj.com)
  • The expression of different vascular endothelial growth factor (VEGF) genes was studied in glioma U87 cells with endoplasmic reticulum-nuclei-1 (ERN1) loss of function and its regulation by hypoxia and glutamine or glucose deprivation conditions as model of ischemia. (scirp.org)
  • Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N (1993) Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. (springer.com)
  • Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. (labcorp.com)
  • Because we found that PAX6 downregulates expression of the gene encoding vascular endothelial growth factor A (VEGFA) in glioma cells, we used a subcutaneous xenograft model to verify PAX6 suppression of VEGFA-induced angiogenesis based on CD31-immunostaining of endothelial cells. (springer.com)
  • Since glioma cells with stable expression of ectopic PAX6 cDNA showed dramatically suppressed growth in vivo, but no significant alteration of cell proliferation in vitro, it appears that PAX6 suppression of glioma tumorigenicity is mediated through changes in the tumor microenvironment, e.g. suppression of tumor angiogenesis. (springer.com)
  • They are important signaling proteins involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). (wikipedia.org)
  • described a factor secreted by tumors causing angiogenisis and called it tumor angiogenesis factor. (wikipedia.org)
  • These neuroprotective effects were related to increased vascular endothelial growth factor and CD31 expression, which promoted angiogenesis. (medindia.net)
  • Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. (uniprot.org)
  • Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. (uniprot.org)
  • Angiogenesis (blood vessel growth), lymphangiogenesis (lymph system growth) are all intrinsically connected with lymphedema and share many of the same genes. (lymphedemapeople.com)
  • Angiogenesis, the formation of new blood vessels sprouting from the pre-existing vasculature, is pivotal for the growth of solid tumors and also plays a critical role in invasion and metastasis. (spandidos-publications.com)
  • Gene targeting shows that most, if not all, of the factors and receptors in this family serve critical functions during vascular development or in adult physiological and pathological angiogenesis. (portlandpress.com)
  • Nitric Oxide Stimulates Vascular Endothelial Growth Factor Production in Cardiomyocytes Involved in Angiogenesis. (thefreedictionary.com)
  • Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat. (thefreedictionary.com)
  • Isoform 111 of Vascular Endothelial Growth Factor (VEGF111) Improves Angiogenesis of Ovarian Tissue Xenotransplantation. (biomedsearch.com)
  • Sex steroid exposure constitutes a risk factor for breast cancer, but little is known about the effects of sex steroids on factors mediating angiogenesis, the development of new blood vessels, in normal and malignant breast tissue. (diva-portal.org)
  • 12-16 Together, these data suggest that administration of exogenous angiogenic growth factors may stimulate both angiogenesis and vasculogenesis for therapeutic neovascularization. (ahajournals.org)
  • Danielle Hsu, Jason M. Shohet and Eugene S. Kim, "Targeting Vascular Endothelial Growth Factor in Neuroblastoma", Current Angiogenesis (Discontinued) (2013) 2: 30. (eurekaselect.com)
  • L. Arakelyan, V. Vainstein and Z. Agur, A computer algorithm describing the process of vessel formation and maturation, and its use for predicting the effects of anti-angiogenic and anti-maturation therapy on vascular tumor growth ,, Angiogenesis , 5 (2002), 203. (aimsciences.org)
  • Clearly, adenosine is fundamentally important in promoting angiogenesis and, subsequently, cancer cell growth and development. (natmedtalk.com)
  • In this study, we have investigated the influence of D16F7 on glioma growth and angiogenesis in vivo using C6 glioma cells transfected with the human VEGFR-1. (aspetjournals.org)
  • In conclusion, therapies such as ZD6474 that target two distinct aspects of tumor growth, angiogenesis and tumor cell proliferation, warrant further investigation. (aacrjournals.org)
  • One target for new therapies is angiogenesis, the dynamic process by which the blood supply of a tumor is created from preexisting blood vessels and endothelial precursor cells ( 3 , 4 ). (aacrjournals.org)
  • 7, 8 Emerging evidence has shown that angiogenesis plays a pivotal role in many physiological and pathological processes, such as tumour growth, arthritis, psoriasis, and diabetic retinopathy. (bmj.com)
  • We hypothesize that a microsphere/hydrogel combination system could be useful for the local and sustained delivery of recombinant human vascular endothelial growth factor (rhVEGF) to enhance angiogenesis in vivo . (springer.com)
  • Pattersonand C, Runge MS. Therapeutic myocardial angiogenesis via vascular endothelial growth factor gene therapy: Moving on down the road. (springer.com)
  • Nicosia R, Nicosia S, Smith M. Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro . (springer.com)
  • Overexpression of VEGFA as well as PFKFB4, PFKFB3 and hexokinase 2 is an obligatory factor of tumor cell glycolysis and increased angiogenesis and proliferation [8-14]. (scirp.org)
  • We conclude that lyso-PC can induce growth factor gene expression in cultured endothelial cells and thus may contribute to the migration and proliferation of smooth muscle cells and fibroblasts in various response-to-injury settings in vivo. (jci.org)
  • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. (labcorp.com)
  • We reported that PAX6 suppresses glioblastoma cell growth in vivo and anchorage-independent growth without significant alteration of cell proliferation in vitro, suggesting that PAX6 may alter the tumor microenvironment. (springer.com)
  • Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. (uniprot.org)
  • We also consider the effect of platelet-derived growth factor-B (PDGF-B) on the proliferation and migration of pericytes. (aimsciences.org)
  • Growth factors are secreted proteins that can stimulate the proliferation and/or differentiation of cells. (helsinki.fi)
  • Hence, there has been recent interest in modifying the surface of platinum GDCs to promote thrombosis and endothelial cell proliferation, and thus reduce the time necessary for aneurysm occlusion (1-7) . (ajnr.org)
  • In vitro , ZD6474 inhibited human umbilical vascular endothelial cell and TMK-1 human gastric tumor cell proliferation in a dose-dependent fashion. (aacrjournals.org)
  • The proliferation and growth of gastric cancer is mediated by a variety of growth factors and cytokines. (aacrjournals.org)
  • Endothelial cell proliferation was significantly enhanced when cells were cultured with the rhVEGF-releasing combination system in vitro . (springer.com)
  • Plouet J, Schilling J, Gospodarowicz D (1989) Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells. (springer.com)
  • Using an in vitro coculture system to mimic the interactions between the cells of the vessel wall, we have previously shown that pericytes and smooth muscle cells (SMC) inhibit the growth of capillary endothelial cells (EC). (pnas.org)
  • This study demonstrates that tmTNF is present in the endothelium of methylcholanthrene (meth A) sarcomas and that the expression of tmTNF in endothelial cells in vitro is linked to an autocrine continuous activation of these cells. (bloodjournal.org)
  • In vitro studies were performed on bovine retinal endothelial cells (BREC) cultured in either 5 or 30 mmol/l glucose with or without 1 μmol/l fidarestat. (diabetesjournals.org)
  • We investigated the role of GDF6 in promoting endothelial vascular integrity in vivo in zebrafish and in cultured human umbilical vein endothelial cells in vitro. (diva-portal.org)
  • To test this hypothesis, we examined the effects of exogenous 20-HETE or a noncyclooxygenase-metabolizable analog, WIT003 [20-hydroxyeicosa-5( Z ),14( Z )-dienoic acid], on human umbilical vein endothelial cells (HUVEC) and dermal microvascular endothelial cells (HDMVEC) in vitro. (aspetjournals.org)
  • Vascular endothelial growth factor expression in choroidal neovascularization in rats," Graefe's Archive for Clinical and Experimental Ophthalmology , vol. 235, no. 5, pp. 313-319, 1997. (hindawi.com)
  • Correlation of increased vascular endothelial growth factor with neovascularization and permeability in ischemic central vein occlusion," Archives of Ophthalmology , vol. 120, no. 12, pp. 1644-1650, 2002. (hindawi.com)
  • Neovascularization is essential for tumour growth and is mediated by physiological substances produced by tumours. (spandidos-publications.com)
  • Risau W (1996) What, if anything, is an angiogenic factor? (springer.com)
  • In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. (curehunter.com)
  • It acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration. (wikipedia.org)
  • Soon thereafter, it was shown to be a specific growth factor for lymphatic vessels in a variety of models. (wikipedia.org)
  • However, in addition to its effect on lymphatic vessels, it can also promote the growth of blood vessels and regulate their permeability. (wikipedia.org)
  • It has been suggested that VEGFC is a morphogen but not a chemotactic factor for lymphatic endothelial cell precursors. (wikipedia.org)
  • Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. (sigmaaldrich.com)
  • Vascular endothelial growth factor receptor 2 (VEGFR2) is highly expressed by lymphatic endothelial cells and has been shown to stimulate lymphangiogenesis in adult mice. (sigmaaldrich.com)
  • Central to the task of growing a lymphatic network are lymphatic endothelial cells (LECs), which constitute the innermost layer of all lymphatic vessels. (frontiersin.org)
  • Lymphatic endothelial cells (LECs) form the innermost layer of lymphatic vessels, and they play a central role during the growth of the lymphatic system ( Bautch and Caron, 2015 ). (frontiersin.org)
  • The VEGFs -A, -B, -C, -D are important signaling molecules with pivotal implication in the growth of blood and lymphatic vessels, the so-called angio- and lymphangiogenesis. (uib.no)
  • Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. (springer.com)
  • Their involvement in pathologic processes such as tumor growth or inflammatory disorders has been thoroughly described, rheumatoid arthritis being just one example. (uib.no)
  • Aggressive pituitary tumors (APTs) including pituitary carcinomas (PCs) are a subset of pituitary tumors with a more aggressive course defined clinically by significant invasion, rapid tumor growth rate, and resistance to optimal standard therapies ( 1 ). (frontiersin.org)
  • Endoplasmic reticulum stress as well as hypoxia is an important factor of tumor growth. (scirp.org)
  • Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells. (jci.org)
  • However, the coordination of inputs from growth factor receptors leading to the selective recruitment or activation of specific integrins in vivo remains poorly understood. (rupress.org)
  • The ex vivo levels of nitric oxide production, inducible nitric oxide synthase, vascular endothelial cell growth factor-C and caspase-3 were also estimated to investigate the possible mechanisms of hepatoprotection. (ijpsonline.com)
  • Senger DR, Perruzzi CA, Feder J, Dvorak HF (1986) A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. (springer.com)
  • identified a vascular permeability factor secreted by tumors in guinea pigs and hamsters. (wikipedia.org)
  • Indeed, growth factor antagonists have been used successfully in diabetes-related animal models to block angiogenic and permeability complications in the retina and kidney. (diabetesjournals.org)
  • 8 An increase of vascular permeability has 2 important consequences for potential therapeutic interventions in tumors: First, it facilitates drug delivery 9 and, secondly, it contributes to the formation of hemorrhagic necroses, which are induced by the administration of the soluble form of tumor necrosis factor-α (TNF), both in experimental tumor models and in isolated limb perfusions in patients. (bloodjournal.org)
  • Both AR inhibitors (ARIs) and antioxidants prevent formation of retinal pericyte ghosts and acellular capillaries ( 1 , 6 , 10 ), increased vascular permeability ( 11 , 12 , 13 ), decreased blood flow and oxygenation ( 7 , 14 ), and impaired leukocyte-endothelial cell interactions resulting in retinal inflammation ( 15 , 16 ). (diabetesjournals.org)
  • Vascular permeability factor: a unique regulator of blood vessel function. (ajtmh.org)
  • These results demonstrate that astrocyte culture conditions differentially affect their ability to modulate brain endothelial barrier function, and suggest a direct relationship between reactive gliosis and BBB permeability. (rti.org)
  • Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. (hindawi.com)
  • No inhibitory activity was detected when media conditioned by individual cultures of EC, SMC, or pericytes were examined for their effect on EC growth. (pnas.org)
  • The relation between diabetes-associated increase in retinal AR activity and oxidative injury remains unexplored, and hyperglycemia-induced oxidative stress is present in cells with both relatively high (retinal pigment epithelial and Muller cells, pericytes) and low (endothelial cells) AR activity [( 19 ), R.N. Frank and A. Kennedy, unpublished]. (diabetesjournals.org)
  • This genetic strategy initially induced a dense network of loosely adjoined endothelial cells and pericytes near lateral ventricles, similar to the immature vascular rete in human fetal brains. (sciencemag.org)
  • In this study, we have found that lyso-PC increased steady state mRNA levels for two smooth muscle/fibroblast-directed growth factors, the A and B chains of PDGF and heparin-binding EGF-like protein (HB-EGF), in cultured human endothelial cells. (jci.org)
  • Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. (labcorp.com)
  • Lyso-PC did not upregulate the expression of certain other inducible endothelial genes, including E-selectin, IL-8, or monocyte chemoattractant protein-1 in the same cells, in contrast to the coordinate pattern of activation typically observed with other stimuli, such as TNF alpha, bacterial endotoxin, or PMA. (jci.org)
  • Combined analysis of vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression in gastric carcinoma," International Journal of Cancer , vol. 74, no. 5, pp. 545-550, 1997. (hindawi.com)
  • observed in mouse that its expression was upregulated by hypoxia and that its cell surface receptor, Flk1, is exclusively expressed in endothelial cells. (lymphedemapeople.com)
  • Transcriptome analysis of hypervascularized islets revealed an increased expression of extracellular matrix components and axon guidance molecules, with these transcripts being enriched in the islet-derived endothelial cell population. (biologists.org)
  • 22.] Stavri GT, Zachary IC, Baskerville PA, Martin JF, Erusalimsky JD (1995) Basic fibroblast growth factor upregulates the expression of vascular endothelial growth factor in vascular smooth muscle cells. (thefreedictionary.com)
  • Real-time polymerase chain reaction revealed that procyanidin treatment reduced expression of vascular endothelial growth factor and effectors in OA pathogenesis that are regulated by vascular endothelial growth factor. (mdpi.com)
  • Procyanidin-suppressed vascular endothelial growth factor expression was correlated with reduced phosphorylation of vascular endothelial growth factor receptor 2 in human OA primary chondrocytes. (mdpi.com)
  • Moreover, components of procyanidins, procyanidin B2 and procyanidin B3 exerted effects similar to those of total procyanidins in mitigating the OA-related gene expression profile in the primary culture of human OA chondrocytes in the presence of vascular endothelial growth factor. (mdpi.com)
  • This study demonstrates that transmembrane expression of tumor necrosis factor (tmTNF) is up-regulated in the endothelium of a murine methylcholanthrene (meth A)-induced sarcoma in comparison to the adjacent normal dermal vasculature and is also present on cultivated human endothelial cells. (bloodjournal.org)
  • Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy. (bmj.com)
  • Stimulation of astrocytes with transforming growth factor (TGF)beta1 decreased transendothelial electrical resistance (TEER) and reduced expression of claudin-5 in co-cultures, whereas treatment of endothelial cells in the absence of astrocytes was without effect. (rti.org)
  • It is reported mildly mitogenic for endothelial cells. (sigmaaldrich.com)
  • The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency," Journal of Biological Chemistry , vol. 271, no. 13, pp. 7788-7795, 1996. (hindawi.com)
  • The mechanism of endothelial cell activation by salt intake required a signaling cascade involving the large-conductance Ca 2+ -activated potassium (BK Ca ) channel, phosphatidylinositol 3-kinase (PI3K), and protein kinase B (also known as Akt). (ahajournals.org)
  • Besides, the thioacetamide-injected groups treated with methanol extract of A. shikokiana and isoepoxypteryxin exhibited a significant increase in the level of caspase-3 protein and a significant decrease of inducible nitric oxide synthase and vascular endothelial cell growth factor C levels when compared with hepatocellular carcinoma group. (ijpsonline.com)
  • 5-8 However, extensive preclinical data have suggested that a portion of the effect of angiogenic cytokines (CKs) involves the mobilization and recruitment of precursor cells, capable of differentiation into endothelial cells, from the bone marrow (BM). (ahajournals.org)
  • Schmidt A, Brixius K, Bloch W. Endothelial precursor cell migration during vasculogenesis. (springer.com)
  • Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancyloss. (thefreedictionary.com)
  • Background- We performed a series of investigations to test the hypothesis that combining angiogenic gene therapy and cytokine (CK)-induced endothelial progenitor cell mobilization would be superior to either strategy alone for treatment of chronic myocardial ischemia. (ahajournals.org)
  • A gene on chromosome 5q31 that encodes fibroblast growth factor 1 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. (thefreedictionary.com)
  • Anti-vascular endothelial growth factor. (ebscohost.com)
  • This is the first reported case in Australia where intravitreal injections of anti-vascular endothelial growth factor ranibizumab were used to successfully. (ebscohost.com)
  • p38 signaling-mediated hypoxia-inducible factor 1 alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells. (cdc.gov)
  • The proteinaceous milieu of malignant pleural effusions contains many growth factors and cytokines that may influence the dynamics of its formation. (aacrjournals.org)
  • Using conditioned media and affinity-purified antibodies to transforming growth factor beta (TGF-beta), we now demonstrate that activated TGF-beta produced in these cocultures mediates EC growth inhibition. (pnas.org)
  • Addition of anti-TGF-beta neutralizing antibodies to cocultures blocked the pericyte-mediated EC growth inhibition. (pnas.org)
  • 2004 ) have also shown that overexpression of CYP4A1 in vascular smooth muscle cells promotes endothelial sprouting in renal arterial microvessels. (aspetjournals.org)
  • de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT (1992) The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. (springer.com)
  • Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, Bohlen P (1992) Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. (springer.com)
  • 1 It has been shown that capillarisation and phenotypic changes of the hepatic sinusoidal endothelial cells (SEC) occur during liver fibrosis development. (bmj.com)
  • Our findings indicate that Src can coordinate specific growth factor and extracellular matrix inputs by recruiting integrin αvβ5 into a FAK-containing signaling complex during growth factor-mediated biological responses. (rupress.org)
  • 1 - 6 These prior studies demonstrated that an increase in dietary salt intake promotes the endothelial cell production of active transforming growth factor-β (TGF-β). (ahajournals.org)
  • High vascular endothelial growth factor activity promotes activation, including junction destabilization and cell motility. (diva-portal.org)
  • We report that GDF6 promotes vascular integrity by counteracting vascular endothelial growth factor activity. (diva-portal.org)
  • Our results suggest that GDF6 promotes vascular stabilization by restraining vascular endothelial growth factor signaling. (diva-portal.org)
  • Adenosine Promotes Cancer Cell Growth. (natmedtalk.com)
  • Treatment of exudative age-related macular degeneration has been revolutionized within the last 6 years with the introduction of vascular endothelial growth factor neutralizing agents. (ebscohost.com)
  • In addition, phosphorylated Akt (S473) and phosphorylation of the endothelial isoform of NO synthase (NOS3) at S1177 increased. (ahajournals.org)
  • Thus, during high salt intake, an increase in TGF-β directly promoted a reduction in endothelial PTEN levels, which in turn regulated Akt activation and NOS3 phosphorylation. (ahajournals.org)
  • GDF6-deficient endothelium has increased vascular endothelial growth factor signaling, increased vascular endothelial-cadherin Y658 phosphorylation, vascular endothelial-cadherin delocalization from cell-cell interfaces, and weakened endothelial cell adherence junctions that become prone to vascular leak. (diva-portal.org)
  • Bikfalvi A. (2017) Vascular Endothelial Growth Factor: The Cornerstone of Vascular Development Factors. (springer.com)
  • 2017. "Quercetin Mitigates Inflammatory Responses Induced by Vascular Endothelial Growth Factor in Mouse Retinal Photoreceptor Cells through Suppression of Nuclear Factor Kappa B. (mdpi.com)
  • In the recent times, the global market for Global vascular endothelial growth factor inhibitor market research report 2017 has surfaced as one of the most promising markets in the pharmaceutical industry, thanks to the significant rise in research and development activities by leading vendors of Global vascular endothelial growth factor inhibitor market research report 2017 across the world. (qyresearchreports.com)
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  • The biology of vascular endothelial growth factor. (nih.gov)
  • Tammela T, Enholm B, Alitalo K, Paavonen K. The biology of vascular endothelial growth factors. (springer.com)
  • Angiogenic factors in particular now appear to play a pivotal role in the development of microvascular complications as well as the response to macrovascular disease. (diabetesjournals.org)
  • Vitreous and serum levels of platelet-derived growth factor and their correlation in patients with proliferative diabetic retinopathy," Current Eye Research , vol. 34, no. 2, pp. 152-161, 2009. (hindawi.com)
  • 134920 ) and platelet-derived growth factors ( 173430 , 190040 ), are active on a wide range of different cell types. (lymphedemapeople.com)
  • It is, however, structurally related to platelet-derived growth factor. (lymphedemapeople.com)
  • These cDNAs encode hydrophilic proteins with sequences related to those of the A and B chains of platelet-derived growth factor. (sciencemag.org)
  • VEGFs are secreted proteins, in contrast to other endothelial cell mitogens such as acidic or basic fibroblast growth factors and platelet-derived endothelial cell growth factor. (sciencemag.org)