The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.
The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.
A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
Endometrial implantation of EMBRYO, MAMMALIAN at the BLASTOCYST stage.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
The hormone-responsive glandular layer of ENDOMETRIUM that sloughs off at each menstrual flow (decidua menstrualis) or at the termination of pregnancy. During pregnancy, the thickest part of the decidua forms the maternal portion of the PLACENTA, thus named decidua placentalis. The thin portion of the decidua covering the rest of the embryo is the decidua capsularis.
The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Pathological processes involving any part of the UTERUS.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.
The period in the MENSTRUAL CYCLE that follows OVULATION, characterized by the development of CORPUS LUTEUM, increase in PROGESTERONE production by the OVARY and secretion by the glandular epithelium of the ENDOMETRIUM. The luteal phase begins with ovulation and ends with the onset of MENSTRUATION.
Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The period of cyclic physiological and behavior changes in non-primate female mammals that exhibit ESTRUS. The estrous cycle generally consists of 4 or 5 distinct periods corresponding to the endocrine status (PROESTRUS; ESTRUS; METESTRUS; DIESTRUS; and ANESTRUS).
Inflammation of the ENDOMETRIUM, usually caused by intrauterine infections. Endometritis is the most common cause of postpartum fever.
Bleeding from blood vessels in the UTERUS, sometimes manifested as vaginal bleeding.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Excessive uterine bleeding during MENSTRUATION.
A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.
The smooth muscle coat of the uterus, which forms the main mass of the organ.
Tumors or cancer of the UTERUS.
Diminished or absent ability of a female to achieve conception.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Abnormal uterine bleeding that is not related to MENSTRUATION, usually in females without regular MENSTRUAL CYCLE. The irregular and unpredictable bleeding usually comes from a dysfunctional ENDOMETRIUM.
An acyclic state that resembles PREGNANCY in that there is no ovarian cycle, ESTROUS CYCLE, or MENSTRUAL CYCLE. Unlike pregnancy, there is no EMBRYO IMPLANTATION. Pseudopregnancy can be experimentally induced to form DECIDUOMA in the UTERUS.
Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading.
Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.
The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
Intrauterine devices that release contraceptive agents.
Pathological processes of the OVARY.
Endoscopic examination, therapy or surgery of the interior of the uterus.
Discrete abnormal tissue masses that protrude into the lumen of the DIGESTIVE TRACT or the RESPIRATORY TRACT. Polyps can be spheroidal, hemispheroidal, or irregular mound-shaped structures attached to the MUCOUS MEMBRANE of the lumen wall either by a stalk, pedunculus, or by a broad base.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
A species of macaque monkey that mainly inhabits the forest of southern India. They are also called bonnet macaques or bonnet monkeys.
A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.
A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
The surgical removal of one or both ovaries.
The period of the MENSTRUAL CYCLE representing follicular growth, increase in ovarian estrogen (ESTROGENS) production, and epithelial proliferation of the ENDOMETRIUM. Follicular phase begins with the onset of MENSTRUATION and ends with OVULATION.
Pathological processes involving the PERITONEUM.
The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
Steroids containing the fundamental tetracyclic unit with no methyl groups at C-10 and C-13 and with no side chain at C-17. The concept includes both saturated and unsaturated derivatives.
Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.
Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
Chemical compounds causing LUTEOLYSIS or degeneration.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Dilatation of the cervix uteri followed by a scraping of the endometrium with a curette.
A mass of histologically normal tissue present in an abnormal location.
A species of baboon in the family CERCOPITHECIDAE with a somewhat different social structure than PAPIO HAMADRYAS. They inhabit several areas in Africa south of the Sahara.
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The extension of endometrial tissue (ENDOMETRIUM) into the MYOMETRIUM. It usually occurs in women in their reproductive years and may result in a diffusely enlarged uterus with ectopic and benign endometrial glands and stroma.
Physiological mechanisms that sustain the state of PREGNANCY.
A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
(6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione. A synthetic progestational hormone used in veterinary practice as an estrus regulator.
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
A post-MORULA preimplantation mammalian embryo that develops from a 32-cell stage into a fluid-filled hollow ball of over a hundred cells. A blastocyst has two distinctive tissues. The outer layer of trophoblasts gives rise to extra-embryonic tissues. The inner cell mass gives rise to the embryonic disc and eventual embryo proper.
Excision of the uterus.
Three or more consecutive spontaneous abortions.
The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.
Variations of menstruation which may be indicative of disease.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
An INTERLEUKIN-6 related cytokine that exhibits pleiotrophic effects on many physiological systems that involve cell proliferation, differentiation, and survival. Leukemia inhibitory factor binds to and acts through the lif receptor.
Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).
The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.
Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types.
The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Production of prostaglandin f2alpha and its metabolite by endometrium and yolk sac placenta in late gestation in the tammar wallaby, Macropus Eugenii. (1/3697)

In this study, we investigated production of prostaglandin (PG) F2alpha and its metabolite, PGFM, by uterine tissues from tammar wallabies in late pregnancy. Endometrial explants were prepared from gravid and nongravid uteri of tammars between Day 18 of gestation (primitive streak) and Day 26.5 (term) and were incubated in Ham's F-10 medium supplemented with glutamine and antibiotics for 20 h. PGF2alpha and PGFM in the medium were assayed by specific, validated RIAs. Control tissues (leg muscle) did not produce detectable amounts of either PG. Both gravid and nongravid endometria secreted PGF2alpha, and production increased significantly in both gravid and nongravid uteri towards term. PGFM was produced in small amounts by both gravid and nongravid uteri, and the rate of production did not increase. Neither oxytocin nor dexamethasone stimulated PG production in vitro in any tissue at any stage. Thus, the surge in peripheral plasma PGFM levels seen at parturition may arise from increased uterine PG production, but further study is needed to define what triggers this release.  (+info)

Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. (2/3697)

Trophinin, tastin, and bystin comprise a complex mediating a unique homophilic cell adhesion between trophoblast and endometrial epithelial cells at their respective apical cell surfaces. In this study, we prepared mouse monoclonal antibodies specific to each of these molecules. The expression of these molecules in the human placenta was examined immunohistochemically using the antibodies. In placenta from the 6th week of pregnancy, trophinin and bystin were found in the cytoplasm of the syncytiotrophoblast in the chorionic villi, and in endometrial decidual cells at the utero placental interface. Tastin was exclusively present on the apical side of the syncytiotrophoblast. Tissue sections were also examined by in situ hybridization using RNA probes specific to each of these molecules. This analysis showed that trophoblast and endometrial epithelial cells at the utero placental interface express trophinin, tastin, and bystin. In wk 10 placenta, trophinin and bystin were found in the intravillous cytotrophoblast, while tastin was not found in the villi. After wk 10, levels of all three proteins decreased and then disappeared from placental villi.  (+info)

Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-tau in bovine endometrial cells. (3/3697)

Oxytocin (OT) is responsible for the episodic release of luteolytic prostaglandin (PG) F2alpha from the uterus in ruminants. The attenuation of OT-stimulated uterine PGF2alpha secretion by interferon-tau (IFN-tau) is essential for prevention of luteolysis during pregnancy in cows. To better understand the mechanisms involved, the effect of recombinant bovine IFN-tau (rbIFN-tau) on OT-induced PG production and cyclooxygenase-2 (COX-2) and PGF synthase (PGFS) expression in cultured endometrial epithelial cells was investigated. Cells were obtained from cows at Days 1-3 of the estrous cycle and cultured to confluence in RPMI medium supplemented with 5% steroid-free fetal calf serum. The cells were then incubated in the presence or absence of either 100 ng/ml OT or OT+100 ng/ml rbIFN-tau for 3, 6, 12, and 24 h. OT significantly increased PGF2alpha and PGE2 secretion at all time points (p < 0.01), while rbIFN-tau inhibited the OT-induced PG production and reduced OT receptor binding in a time-dependent manner. OT increased the steady-state level of COX-2 mRNA, measured by Northern blot, which was maximal at 3 h (9-fold increase) and then decreased with time (p < 0.01). OT also caused an increase in COX-2 protein, which peaked at 12 h (11-fold increase), as measured by Western blot. Addition of rbIFN-tau suppressed the induction of COX-2 mRNA (89%, p < 0.01) and COX-2 protein (50%, p < 0.01) by OT. OT also increased PGFS mRNA, and this stimulation was attenuated by rbIFN-tau (p < 0.01). To ensure that the decrease in COX-2 was not solely due to down-regulation of the OT receptor, cells were stimulated with a phorbol ester (phorbol 12-myristate 13-acetate; PMA) in the presence and absence of rbIFN-tau. The results showed that rbIFN-tau also decreased PMA-stimulated PG production and COX-2 protein. It can be concluded that rbIFN-tau inhibition of OT-stimulated PG production is due to down-regulation of OT receptor, COX-2, and PGFS.  (+info)

Molecular and cellular aspects of endometrial receptivity. (4/3697)

Endocrine and paracrine controls regulate the endometrium during the luteal phase of the cycle to permit implantation. Part of this differentiation process is the production of a specific secretion which fills the intrauterine cavity and glandular lumen. Its molecular composition originates from the gland secretion, from transudations from stroma, from the endometrial blood vessels, and last, but not least, from cellular components of apoptotic and exfoliated cells. We have studied the secretions of all phases during the menstrual cycle using patterns evaluated by SDS-PAGE, by laser densitometry or Western blots. Uterine secretion electrophoresis (USE) permits detailed analyses of the intrauterine micromilieu and allows clinical assessment of the receptive stage of endometrium during the luteal phase. Several individual protein bands have been defined as characteristic markers for such receptive pattern. We have isolated and identified the molecular structure of several of these proteins, e.g. histones, cyclophilin, transthyretin, haptoglobin and uteroglobin. Investigations on the endocrine regulation of these proteins, were carried out on the uterine secretions of patients treated with progesterone antagonists (mifepristone and onapristone). The results demonstrate how progesterone-dependent components produce a receptive pattern, which can serve as a useful and precise marker in the clinical diagnosis of the luteal phase. Essential progesterone-dependent components differentiating during the luteal phase may provide new targets for contraceptive interventions by preventing the physiological changes typical of receptivity.  (+info)

Molecular control of the implantation window. (5/3697)

Human endometrium is the end organ of the hypothalamic-pituitary-ovarian axis. Therefore, endometrium is susceptible to changes in the cases of infertility that originate from disturbances in the normal functioning of this axis. In addition, some cases of unexplained infertility may be due to altered endometrial function. This disturbed endometrial function may originate from lesions in the molecular repertoire that are crucial to implantation. Human endometrium becomes receptive to implantation by the blastocyst within a defined period during the menstrual cycle. The duration of this so-called 'endometrial receptivity' or 'implantation' period seems to span from few days after ovulation to several days prior to menstruation. Successful implantation results from a co-ordinated series of events that would allow establishment of a timely dialogue between a receptive endometrium and an intrusive blastocyst. The members of the molecular repertoire that make endometrium receptive to implantation are gradually being recognized. Among these are the cytokines, integrins, heat shock proteins, tastin and trophinin. In addition, the expression of a second set of genes including tumour necrosis factor alpha (TNF-alpha) and ebaf, may be the appropriate signal for the closure of the 'implantation window', for making the endometrium refractory to implantation and for preparing it for the menstrual shedding.  (+info)

Marker genes of decidualization: activation of the decidual prolactin gene. (6/3697)

Decidualization of human endometrial stromal (ES) cells in vitro is induced by cAMP analogues and ligands that elevate cellular cAMP levels in a manner resembling the gonadotrophins, prostaglandin E2 and relaxin (RLX). This differentiation process is marked by the onset of decidual prolactin (PRL) production in the late luteal phase of the cycle. Using transfection assays and a primary ES cell culture system, we have demonstrated that decidual PRL gene transcription is driven by an alternative upstream promoter (dPRL), approximately 6 kb upstream of the pituitary transcription start site. In primary cell cultures, RLX not only acutely but also permanently elevated cellular cAMP levels and induced PRL secretion after 6 days. Northern and Western blot analyses revealed all regulatory subunit isoforms (RIalpha, RIbeta, RIIalpha, RIIbeta) and catalytic subunits Calpha and Cbeta of protein kinase A (PKA) in ES cells. Transcript levels of PKA subunit isoforms are not altered during decidualization, but in decidualized ES cells exposed to elevated cellular cAMP levels by stimulation with RLX for >6 days, RIalpha protein levels were significantly reduced, whereas levels of all other forms remained unchanged. Reducing the availability of R subunits changed the R:C subunit ratio in favour of C and increased kinase activity. In transient transfections of undifferentiated ES cells, the dPRL promoter was activated by 8-Br-cAMP and by C subunit (Cbeta) of PKA. This induction, and the differentiation-dependent activity of the dPRL promoter in transfected decidualized cells, was effectively abolished by the co-expression of protein kinase inhibitor (PKI). A fragment of 332 bp of 5'-flanking region of the dPRL transcription start site was sufficient to mediate full inducibility by cAMP. cAMP activation of the dPRL promoter in ES cells was biphasic as an initial weak induction within 12 hours was followed by a subsequent, much more intense induction after 12 hours. The secondary induction was not seen with a control construct driven by a consensus cAMP response element (CRE) linked to a minimal promoter. The early response of the dPRL promoter depended upon a non-palindromic CRE at position -12 and mutation of this sequence led to omission of the early, but not of the delayed, induction. The major activation of the dPRL promoter depended upon a different region between position -332 and -270 since its deletion significantly reduced inducibility by cAMP. Its action was probably indirect as its kinetics differed from classic CRE-mediated responses, and it was specific to ES cells.  (+info)

Changes in basement membrane thickness in the human endometrium during the luteal phase of the menstrual cycle. (7/3697)

We have examined aspects of the fine structure of the basal laminae associated with the luminal and glandular epithelium and small blood vessels in the human endometrium. Four short studies are presented and reviewed. Study 1 examined biopsies from 20 fertile women taken on days after the luteinizing hormone surge (LH): LH +2, 4, 6, 8 and 10. The basal lamina (both lamina densa and lucida) increased in thickness over the period studied. Study 2 again studied the glandular epithelium and examined the effect of RU486 (a progesterone receptor blocker) administered on day LH +3 and biopsied on day LH +6. The basal laminae were found to be the same as LH +2 control group but thinner than LH +6 control. Study 3 documented increased thickness of the basal laminae between LH +6, 8 and 13 in the luminal epithelium. The within-group coefficient of variation was 16% and 27% for LH +6 and LH +13 groups but only 2 % for LH +8. Study 4 demonstrated an increase in basal lamina thickness associated with small blood vessels between LH +6 and LH +10 in normal fertile women. The basal lamina provides the interface between epithelial and mesenchymal environments; changes in its structure can alter the phenotypic expression of the epithelia. It is one of the maternal barriers that must be transgressed by the trophoblast during implantation. Together, these combined studies provide quantitative baseline structural information on the electron microscopical appearance of the basal lamina during the luteal phase of the menstrual cycle.  (+info)

Endometrial microvascular growth in normal and dysfunctional states. (8/3697)

As a tissue that exhibits rapid cyclical growth and shedding throughout the reproductive life of the female, human endometrium provides a good model for the study of normal physiological angiogenesis. The objective of this paper is to summarize recent data on endometrial vascular growth, present new data on regional variability in endothelial cell proliferation within the endometrium, and interpret this information in light of current knowledge of the mechanisms by which angiogenesis occurs. Conventional angiogenesis normally involves a series of steps which include endothelial cell activation, breakdown of the basement membrane, migration and proliferation of the endothelial cell, fusion of sprouts, and tube formation. Other mechanisms by which angiogenesis occurs include intussusception and vessel elongation. Using immunohistochemical techniques we have shown repeatedly that levels of endothelial cell proliferation within human endometrium do not show any consistent pattern across the different stages of the menstrual cycle, which is unexpected since significant vascular growth must occur during the proliferative phase, when the endometrium increases in thickness by up to 4-fold. There are two possible explanations for this; either there is no obligatory link between endometrial endothelial cell proliferation and new vessel formation, or there is significant variation in endothelial cell proliferation within different regions of the same uterus. Multiple samples from hysterectomy specimens subsequently demonstrated that the variability is due to real differences between individuals, as well as showing that the endothelial cell proliferation index is significantly elevated in functionalis compared with basalis. During these studies we observed that endothelial cell proliferation nearly always appeared inside existing endometrial vessels, rather than be associated with structures that could be identified as vascular sprouts. To explore further whether sprout formation occurs during endometrial angiogenesis, we investigated the immunohistochemical distribution of integrin alphavbeta3 on endometrial endothelial cells. As for endothelial cell proliferation, integrin alphavbeta3 immunostaining was seen only on endothelial cells that appeared within existing blood vessels. The results from these studies have major implications for our understanding of the mechanisms that control endometrial angiogenesis. The lack of correlation between menstrual cycle stage and endothelial cell proliferation index, or endothelial cell expression of integrin alphavbeta3, suggests that vascular growth is not under the overall control of oestrogen and progesterone.  (+info)

TY - JOUR. T1 - Differences in lectin binding patterns of normal human endometrium between proliferative and secretory phases. AU - Aoki, D.. AU - Kawakami, H.. AU - Nozawa, S.. AU - Udagawa, Y.. AU - Iizuka, R.. AU - Hirano, H.. PY - 1989/5/1. Y1 - 1989/5/1. N2 - Lectin binding patterns in normal human endometrium were examined by light and electron microscopy using seven different lectins (ConA, WGA, RCA, PNA, UEA-1, DBA, and SBA). For light microscopic observations, criteria based on the incidence and intensity of cells positive for the lectin staining were adopted to evaluate the different staining patterns of the proliferative and secretory endometria obtained by the avidin-biotin-peroxidase complex (ABC) technique. At the light microscopic level, ConA, WGA, and RCA stained endometrial glandular cells in both phases. The number of PNA-positive cells with the binding sites entirely limited to the apical surface tended to be reduced slightly in the secretory phase. UEA-1 weakly stained the ...
Define secretory endometrium. secretory endometrium synonyms, secretory endometrium pronunciation, secretory endometrium translation, English dictionary definition of secretory endometrium. n. pl. en·do·me·tri·a The glandular mucous membrane that lines the uterus. en′do·me′tri·al adj. American Heritage® Dictionary of the English Language, Fifth...
Evidence from an abundant number of studies suggests that human female reproductive functions have become impaired over the past half century and that there might be a relationship between endocrine disrupting chemicals (EDCs) and reduced fertility. It is, however, not known by what mechanisms EDCs affect different reproductive functions such as endometrial receptivity, embryo implantation and placentation.. The endometrium is continuously changing its morphological and functional properties, responding to cyclic changes of oestrogen and progesterone levels during the menstrual cycle. These changes include monthly preparation for embryo implantation through changed endometrial angiogenic activity and consequent changes in endometrial vasculature.. Use of primary human endometrial endothelial cells (HEECs) in this work was evaluated as a possible screening tool for effects caused by EDCs on human endometrial vasculature and subsequently on various endometrial functions.. In this study HEEC and ...
The cyclic production of estrogen and progesterone during the ovarian cycle induces a corresponding cycle of endometrial proliferation and development. (Fig. 1, bottom panel). This endometrial cycle includes a proliferative phase lasting about 11 days, a secretory phase lasting about 12 days, and a desquamative or menstrual phase of about five days during which menstruation ensues.. During the follicular phase of the ovarian cycle, the endometrium proliferates and increases in thickness under the influence of estradiol. This marks the proliferative phase of the endometrial cycle. During the luteal phase of the ovarian cycle, progesterone stimulates further endometrial cell proliferation, differentiation, and secretory development to support implantation and to nourish the developing conceptus. This is the secretory phase of the endometrial cycle. Progesterone also promotes secretory changes in the lining of the fallopian tubes that will support the fertilized egg as it travels down the fallopian ...
Introduction: We often see patients with a thin endometrium in ART cycles, in spite of standard and adjuvant treatments. Improving endometrial growth in patients with a thin endometrium is very difficult. Without adequate endometrial thickness these patients, likely, would not have reached embryo transfer. Materials and Methods: This is a non randomized intervential clinical trial. Among 68 infertile patients with thin endometrium (7 mm) at the 12th-13th cycle day, 34 patients received G-CSF (300 microgram/lmL) to improve endometrial thickness. It was directly administered by slow intrauterine infusion using IUI catheter. If the endometrium had not reached at least a 7-mm within 48-72 h, a second infusion was given. Endometrial thickness was assessed by serial vaginal ultrasound at the most expanded area of the endometrial stripe. The cycle was cancelled in the patients with thin endometrium (endometrial thickness 7mm) until 19th cycle day ultimately. Results: The cycle cancelation rate owing to ...
TY - JOUR. T1 - Global Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis. AU - Herndon, Christopher N.. AU - Aghajanova, Lusine. AU - Balayan, Shaina. AU - Erikson, David. AU - Barragan, Fatima. AU - Goldfien, Gabriel. AU - Vo, Kim Chi. AU - Hawkins, Shannon. AU - Giudice, Linda C.. PY - 2016/10/1. Y1 - 2016/10/1. N2 - Objective: Adenomyosis is a clinical disorder defined by the presence of endometrial glands and stroma within the myometrium, the pathogenesis of which is poorly understood. We postulate that dysregulation of genes and pathways in eutopic endometrium may predispose to ectopic implantation. No study, to our knowledge, has examined the global transcriptome of isolated eutopic endometrium from women with clinically significant adenomyosis. Design: Laboratory-based study with full institutional review board approval and consents. Material and Methods: Endometrial sampling was performed on hysterectomy specimens (proliferative phase) from symptomatic ...
TY - JOUR. T1 - Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua. AU - Kaituu-Lino, Tuuhevaha J. AU - Ye, Louie. AU - Tuohey, Laura. AU - Dimitriadis, Evdokia. AU - Bulmer, Judith N. AU - Rogers, Peter. AU - Menkhorst, Ellen. AU - Van Sinderen, Michelle Leigh. AU - Girling, Jane Eleanor. AU - Hannan, Natalie J. AU - Tong, Stephen. PY - 2013. Y1 - 2013. N2 - STUDY QUESTION: What is the nature of cellular Corin expression in human gestational tissues? SUMMARY ANSWER: CORIN is expressed in non-pregnant late secretory phase endometrium, first trimester human implantation sites and is up-regulated with decidualization ex vivo. WHAT IS KNOWN ALREADY: Adequate trophoblast invasion and spiral artery remodeling/transformation is critical for successful implantation. CORIN, best known for its role in activating atrial natruietic peptide (ANP) to regulate blood pressure, has recently been proposed to be centrally ...
The aim of the study was to assess the effectiveness of progesterone (P) administered by nasal spray (NS) in inducing secretory changes within estrogen and non-estrogen primed postmenopausal endometrium. Ten healthy post-menopausal women before vaginal hysterectomy for prolapse were randomly treated by either oral estrogens for 3-4 weeks combined for the last 5-7 days with nasally administered P at the daily dose of 34 mg, or by only P for 6 days. Endometrial samples were taken before P administration and 8 h after the last dose. In the group not treated with estrogens, P did not induce significant secretory changes in any case except one which showed a proliferative endometrial pattern at the first evaluation. In the group treated with estrogens, in all the cases after P administration clear secretory changes (abundant vacuoles, endoluminal secretion) occurred. It is possible to conclude that P administered by NS exerts an end-organ effect within the endometrium of postmenopausal women ...
Uterus, early proliferative phase aka Uterus, early proliferative phase in the latin terminology and part of histology of the uterus during early stages of the proliferative phase. Learn more now!
Looking for Endometrial cycle? Find out information about Endometrial cycle. The periodic series of changes associated with menstruation and the intermenstrual cycle; menstrual bleeding indicates onset of the cycle. a complex... Explanation of Endometrial cycle
Invasion of the trophoblast into the maternal decidua is regulated by both the trophoectoderm and the endometrial stroma, and entails the action of tissue remodeling enzymes. Trophoblast invasion requires the action of metalloproteinases (MMPs) to degrade extracellular matrix (ECM) proteins and in turn, decidual cells express tissue inhibitors of MMPs (TIMPs). The balance between these promoting and restraining factors is a key event for the successful outcome of pregnancy. Gene expression is post-transcriptionally regulated by histone deacetylases (HDACs) that unpacks condensed chromatin activating gene expression. In this study we analyze the effect of histone acetylation on the expression of tissue remodeling enzymes and activity of human endometrial stromal cells (hESCs) related to trophoblast invasion control. Treatment of hESCs with the HDAC inhibitor trichostatin A (TSA) increased the expression of TIMP-1 and TIMP-3 while decreased MMP-2, MMP-9 and uPA and have an inhibitory effect on trophoblast
The endometrium undergoes extensive changes to prepare for embryo implantation and microRNAs (miRNAs) have been described as playing a significant role in the regulation of endometrial receptivity. However, there is no consensus about the miRNAs involved in mid-secretory endometrial functions. We analysed the complete endometrial miRNome from early secretory (pre-receptive) and mid-secretory (receptive) phases from fertile women and from patients with recurrent implantation failure (RIF) to reveal differentially expressed (DE) miRNAs in the mid-secretory endometrium. Furthermore, we investigated whether the overall changes during early to mid-secretory phase transition and with RIF condition could be reflected in blood miRNA profiles. In total, 116 endometrial and 114 matched blood samples collected from two different population cohorts were subjected to small RNA sequencing. Among fertile women, 91 DE miRNAs were identified in the mid-secretory vs. early secretory endometrium, while no ...
Secretory endometrium means that the cells the endometrium are producing substances necessary to support implantation of an egg should conception occur.
STUDY HYPOTHESIS: The mouse endometrium harbours stem/progenitor cells that express the stem cell marker mouse telomerase reverse transcriptase (mTert). STUDY FINDING: We used a mouse carrying a transgenic reporter for mTert promoter activity to identify rare endometrial populations of epithelial and endothelial cells that express mTert. WHAT IS KNOWN ALREADY: Stem/progenitor cells are hypothesized to be responsible for the remarkable regenerative capacity of the endometrium, but the lack of convenient endometrial stem/progenitor markers in the mouse has hampered investigations into the identity of these cells. STUDY DESIGN, SAMPLES/MATERIALS, METHODS: A mouse containing a green fluorescent protein (GFP) reporter under the control of the telomerase reverse transcriptase promoter (mTert-GFP) was used to identify potential stem/progenitor cells in the endometrium. mTert promoter activity was determined using fluorescence microscopy and flow cytometry to identify GFP(+) cells. GFP(+) cells were examined
Osteen, K.G.; Keller, N.R.; Feltus, F.A.; Melner, M.H., 1999: Paracrine regulation of matrix metalloproteinase expression in the normal human endometrium
TY - JOUR. T1 - Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium. AU - Gao, F.. AU - Xu, F. H.. AU - Zhou, X. C.. AU - Han, X. B.. AU - Liu, Y. X.. PY - 2001/7/3. Y1 - 2001/7/3. N2 - AIM: To investigate the anti-implantation mechanism of mifepriston. METHODS: In situ hybridization and immunohistochemistry were applied to determine mRNA and protein. RESULTS: After mifepriston injection, the number of implantation sites were obviously reduced, mifepriston could inhibit the embryo implantation in mouse. The expression of apoptosis related genes, Fas and FasL, in mouse endometrium was also decreased after mifepriston treatment. CONCLUSION: The expression of apoptosis related genes Fas and FasL is regulated by mifepriston and the inhibitory effect of mifepriston on the embryo implantation may be mediated by action on the Fas/FasL system.. AB - AIM: To investigate the anti-implantation mechanism of mifepriston. METHODS: In situ hybridization and ...
Differentiation of human endometrial stromal cells (HESCs) into decidual cells represents a highly coordinated process essential for embryo implantation. Following the post-ovulatory rise in progesterone levels HESCs undergo biochemical and morphological transformation in a process known as decidualization. It heralds the end of the mid-secretory phase implantation window, defined as the limited period during which progesterone-driven changes in the luminal epithelium allow apposition, attachment and invasion of a developmentally competent blastocyst. Failure of the endometrium to acquire a receptive phenotype is widely viewed as a major cause of infertility and IVF treatment failure. Conversely, recurrent pregnancy loss (RPL) is associated with impaired decidualization. Firstly, analysis of mid-secretory endometrial biopsies from RPL patients demonstrated that there is a decreased expression of the decidual marker, Prolactin but increased levels of pro-inflammatory cytokine, Prokineticin-1. ...
The origin and process of regeneration in rabbit endo metrium was evaluated following photodynamic epithelial destruction using topically applied anilnolevulinic acid (ALA). Selective destruction of endometrial epithelium was performed using photodynamic therapy (PDT). ALA was diluted to 200 mg/ml dextran 70 shortly prior to adininistra tion. A volume of 1.2 ml was injected into the left uterus. Intrauterine illumination (wavelength 630 nm, light dose 40-80 J/cm2was performed 3 h after drug administration. Tissue morphology was evaluated by light and scanning electron microscopy 1, 3, 7 and 28 days post-treatment (three animals at each dine-point). Regeneration of the endometriwn following epithelial ablation by PDT was fully activated after 24 h and was completed after 72 h. Endometrial surface generation occurred by proliferation, originating primarily in deeper regions of the glands. Findings from our morphological follow-up study support the origin of endometrial regeneration being mainly ...
Estrogen and progesterone induce characteristic and predictable morphological changes in the endometrium that are required for successful implantation and pregnancy. The mechanism(s) by which estrogen and progesterone exert these effects on the endometrium is not known. This is a tissue collection protocol to obtain endometrium and/or menstrual effluent from normally cycling women, women with endometriosis and women with infertility.. This tissue will be used for future studies intended to understand gonadal steroid action on the endometrium We propose to identify peptides that are induced by endogenous estrogen and progesterone using in situ hybridization, immunohistochemistry, microarray analysis and/or culture of human endometrium obtained at hormonally different times of the cycle. Regularly cycling women not at risk for pregnancy will be studied for two menstrual cycles. The first, pre-biopsy cycle, will be characterized by daily basal body temperature measurements and a luteal phase ...
Here, we demonstrate that bone marrow-derived stem cells engraft the murine endometrium. Both stromal and epithelial cells were derived from bone marrow origin. These data show the potential for stem cells to have a role in the regeneration or repair of this tissue after injury. However, the small number of engrafted cells limits their potential to significantly contribute to cyclic endometrial function during each estrus cycle. In other organs, the homing and engraftment of stem cells are influenced by injury and inflammation, presumably through the generation of a signal emanating from the damaged tissue [17, [18]-19]. A more significant engraftment of endometrium by bone marrow is likely to occur after endometrial injury or inflammatory insult. Additionally, the proliferation and development of endometrium are entirely regulated by hormonal stimuli. Ovarian estrogen and progesterone drive endometrial growth and apoptosis [20, 21]. As the radiation used prior to bone marrow transplantation ...
All normal somatic cells are thought to acquire mutations, but understanding of the rates, patterns, causes and consequences of somatic mutations in normal cells is limited. The uterine endometrium adopts multiple physiological states over a lifetime and is lined by a gland-forming epithelium1,2. Here, using whole-genome sequencing, we show that normal human endometrial glands are clonal cell populations with total mutation burdens that increase at about 29 base substitutions per year and that are many-fold lower than those of endometrial cancers. Normal endometrial glands frequently carry driver mutations in cancer genes, the burden of which increases with age and decreases with parity. Cell clones with drivers often originate during the first decades of life and subsequently progressively colonize the epithelial lining of the endometrium. Our results show that mutational landscapes differ markedly between normal tissues-perhaps shaped by differences in their structure and physiology-and indicate
TY - JOUR. T1 - Implantation in the baboon. T2 - Endometrial responses. AU - Fazleabas, A. T.. AU - Kim, J. J.. AU - Srinivasan, S.. AU - Donnelly, K. M.. AU - Brudney, A.. AU - Jaffe, R. C.. PY - 1999. Y1 - 1999. N2 - Blastocyst implantation in the baboon usually occurs between 8 and 10 days post ovulation. Changes that occur within this window of receptivity and immediately following implantation can be divided into three distinct phases. The first phase, regulated by estrogen and progesterone, is characterized primarily by changes in both the luminal and glandular epithelial cells in preparation for blastocyst apposition and attachment. The second phase is the further modulation of these steroid induced changes in both epithelial and stromal cells by embryonic signals. The final phase is associated with trophoblast invasion and the remodeling of the endometrial stromal compartment. During the initial phase, the actions of estrogen and progesterone are dependent on the presence of specific ...
TY - JOUR. T1 - Inflammosome in the human endometrium: further step in the evaluation of the maternal side. AU - Rossi, Esther. AU - Scambia, Giovanni. AU - Di Simone, Nicoletta. AU - DIppolito, Silvia. AU - Tersigni, Chiara. AU - Marana, Riccardo. AU - Di Nicuolo, Fiorella. AU - Gaglione, Raffaele. AU - Castellani, Roberta. PY - 2016. Y1 - 2016. N2 - Objective: To investigate the expression of inflammosome components (NALP-3, associated speck-like protein containing a CARD [ASC]) and their activation (caspase-1, interleukin [IL]-1b, and IL-18 secretion) in the human endometrium from fertile and women with history of recurrent pregnancy loss (RPL). Design: Experimental study. Setting: University hospital. Patient(s): Ten fertile women (control group [CTR]) and 30 women with RPL. Intervention(s): None. Main Outcome Measure(s): Endometrial samples were collected by hysteroscopy during the putative window of implantation and evaluated for chronic endometrial inflammation by hystopathological ...
The only advise that I could offer you is to repeat your IVF cycle with PGD and blastocyst culture coupled with laser assisted hatching. Furthermore the endometrium has to be carefully monitored and in particular endometrial blood flow has to be assessed by ultrasound Doppler. All avenues to improve endometrial blood flow and receptivity needs to be explored and low does cortizone treatment may be necessary to enhance implantation. Unfortunately in this situation persistence is the only answer and we have had cases where patients have finally succeeded after 10 and 12 attempts at IVF ...
Galindo, S. T., Mesquita, F. S., Amaral, H. O. A., Scolari, S. C., França, M., Ramos, R., et al. (2012). Characterization of the endometrial gene expression profile on day 7 post-estrus in response to a bovine model for modulation of the periovulatory endocrine milieu. Animal Reproduction. Belo Horizonte: CBRA. Recuperado de http://www.cbra.org.br/pages/publicacoes/animalreproduction/issues/download/v9n4/p837-1037. ...
TY - JOUR. T1 - Molecular identification of latent precancers in histologically normal endometrium. AU - Mutter, G. L.. AU - Ince, Tan. AU - Baak, J. P A. AU - Kust, G. A.. AU - Zhou, X. P.. AU - Eng, C.. PY - 2001/6/1. Y1 - 2001/6/1. N2 - Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands that fail to express PTEN protein because of mutation and/or deletion. These persist between menstrual cycles. Histopathology of PTEN-null glands is initially unremarkable, but with progression, they form distinctive high-density clusters. These data are consistent with a progression model in which initial mutation is not rate limiting.. AB - Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by ...
Endometrium adalah lapisan terdalam pada rahim dan tempatnya menempelnya ovum yang telah dibuahi. Diperlukan waktu sekitar 4-5 hari setelah pembuahan. Di dalam lapisan Endometrium terdapat pembuluh darah yang berguna untuk menyalurkan zat makanan ke lapisan ini. pembuluh darah ini akan luruh dan menyebabkan terjadinya menstruasi pada wanita apabila tidak terjadi pembuahan ovum oleh sel sperma. Saat ovum yang telah dibuahi (yang biasa disebut fertilisasi) menempel di lapisan endometrium (implantasi), maka ovum akan terhubung dengan badan induk dengan plasenta yang berhubung dengan tali pusat pada bayi. Pada suatu fase di mana ovum tidak dibuahi oleh sperma, maka kurpus luteum akan berhenti memproduksi hormon progesteron dan berubah menjadi korpus albikan yang menghasilkan sedikit hormon diikuti meluruhnya lapisan endometrium yang telah menebal, karena hormon estrogen dan progesteron telah berhenti diproduksi. Pada fase ini, biasa disebut menstruasi atau peluruhan dinding rahim. ...
Aim: We aimed to study biological properties of human endometrial stromal cells in vitro. Materials and Methods: The endometrium samples (n = 5) were obtained
A receptive endometrium and viable blastocyst are the two necessary conditions of successful implantation. The endometrium is receptive only during the window of implantation, which lasts approximately four days (day 20-23), and occurs in humans during the mid-secretory phase in a normal 28-day menstrual cycle. With some disparity between sources, it has been stated to occur from 7 days after ovulation until 9 days after ovulation, or days 6-10 postovulation. On average, it occurs during the 20th to the 23rd day after the last menstrual period. During the window of implantation, the endometrium undergoes extensive morphological and physiological changes to facilitate implantation of the embryo, including becoming more vascular and edematous with the glands displaying enhanced secretory activity. This process is precisely regulated. Among all the regulating elements, reproductive hormones are the leading factors. These changes are collectively known as the plasma membrane transformation and bring ...
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Prolactin production was induced in HESCs in response to 8-br-cAMP and P. Dihydrotestosterone further enhanced the secretion of PRL in cells treated with 8-br-cAMP plus P. The effect of DHT was blocked by the antiandrogen flutamide. Dihydrotestosterone enhanced resistance to oxidative stress-induced apoptosis on decidualized HESCs. Moreover, DHT enhanced FOXO1 expression in parallel with increased SOD2 protein but not with SOD1.. Conclusion(s): ...
Endometrial cells from the uteri of pregnant and nonpregnant cattle were cultured. The presence of one or both of two viruses, noncytopathic mucosal disease virus and bovine syncytial virus, was demonstrated in seven of 19 endometria investigated. It was necessary to subculture the cells an average of four times to detect the viral infections. Difficulties were encountered in producing endometrial cell cultures from cows at term or near the end of term and also from older animals. The infections detected may be significant because both of the viruses isolated are capable of infecting the bovine fetus in utero and mucosal disease virus has been associated with bovine fetal diseases.
However if the lining remains thin in spite of high doses of estrogen, this means the problem is either one of poor blood supply ; or a damaged endometrium. Some doctors have used color Doppler ultrasound to measure uterine blood flow, but the results with this have been mixed. Others have tried using vaginal viagra to try to improve endometrial blood flow. Since there is no reliable method to assess uterine blood flow , the next step is to determine whether the endometrium has been damaged or not. There are two possible causes of end-organ damage when the endometrium is nonresponsive. One is that the endometrium has been anatomically distorted because of intrauterine adhesions ( a common cause for this in India is uterine tuberculosis. This condition is called Ashermann syndrome; and this can be diagnosed either with a hysterosalpingogram , which shows filling defects within the uterine cavity ; or with hysteroscopy , during which procedure the scars can be surgically removed. However in some ...
Cominelli, Antoine ; Gaide Chevronnay, Héloïse P. ; Courtoy, Pierre J. ; Henriet, Patrick ; Marbaix, Etienne. Matrix Metalloproteinase-27 is expressed in CD163+/CD206+ macrophages in the human endometrium and in endometriotic lesions.5th European Network of Immunology Institutes Summer School in advanced Immunology (Capo Caccia, Sardinia, Italy ...
Results of recent studies in sheep support the concept that PGs regulate expression of elongation- and implantation-related genes in the endometrial epithelia of ruminants during early pregnancy and are involved in conceptus elongation [46, 60, 98] (Figures 1 and 2). The conceptus and endometria synthesize a variety of PGs during early pregnancy in both sheep and cattle [99-104]. The endometrium produces and uterine lumen contains substantially more PGs during early pregnancy than during the estrous cycle [105-107]. The dominant cyclooxygenase expressed in both the endometrium and trophectoderm of the elongating conceptus is PTGS2 [104-106]. Although the antiluteolytic effects of IFNT are to inhibit expression of the OXTR in the endometrial LE and sGE of early pregnant ewes, it does not impede up-regulation of PTGS2, a rate-limiting enzyme in PG synthesis [102, 107]. In sheep, PTGS2 activity in the endometrium is stimulated by IFNT, and PTGS2-derived PG were found to mediate, in part, the ...
Similar endometrial development in oocyte donors treated with either high-or. The acceptability of posthumous human ovarian tissue donation in Utah.Czy po częściowym usunięciu jajników wraz z endometrium można zajść w ciążę? Zespół policystycznych jajników (pcos-Polycystic Ovary Syndrome),. Policystycznych jajników (pcos, ang. Polycystic ovarian syndrome). Endometrioza poprzez szereg różnych czynników może wywierać wpływ na płodność.Takie endometrialne implanty odpowiadają podobnie jak endometrium w macicy na zmiany. Zespół policystycznych jajników (Polycystic Ovarian Syndrome, pco). The histology of the cyst has shown that the left ovarian cyst was endometriosis and the right one was a dermoid. Neither of these needs any further follow. Zmiany rozrostowe endometrium. asco 2010: Algorytm roca (Risc of Ovarian Cancer Algorithm) w badaniu przesiewowym w kierunku raka.Zespół hiperstymulacji jajników (w skrócie ohss, od angielskiej nazwy„ ovarian. Cieńsze ...
BACKGROUND: For the current report, the authors examined the characteristic features of morphology and molecular biology of phosphatase and tensin homolog (PTEN), beta-catenin, and p53 immunocytochemistry in endometrial carcinoma by using thin-layer cytologic preparations. METHODS: During a 6-month period, 120 endometrial samples were collected directly by using the Uterobrush, and thin-layer specimens were prepared. Immunocytochemical expression levels of PTEN, beta-catenin, and p53 were investigated by using 40 specimens of endometrial carcinoma (EC), and 30 specimens each of proliferative endometrium, secretory endometrium, and atrophic endometrium ...
To study the effect of endometrial thickness and pattern measured using ultrasound upon pregnancy outcomes in patients undergoing IVF-ET. One thousand nine hundred thirty-three women undergoing IVF treatment participated in the study. We assessed and recorded endometrial patterns and thickness on the day of human chorionic gonadotropin (hCG) administration. Receiver operator curves (ROC) were used to determine the predictive accuracy of endometrial thickness. Cycles were divided into 3 groups depending on the thickness (group 1: ≤ 7 mm; group 2: | 7 mm to ≤ 14 mm; group 3: | 14 mm). Each group was subdivided into three groups according to the endometrial pattern as follows: pattern A (a triple-line pattern consisting of a central hyperechoic line surround by two hypoechoic layers); pattern B (an intermediate isoechogenic pattern with the same reflectivity as the surrounding myometrium and a poorly defined central echogenic line); and pattern C (homogenous, hyperechogenic endometrium). Clinical
Table_5_Differential microRNA Expression in Porcine Endometrium Involved in Remodeling and Angiogenesis That Contributes to Embryonic Implantation.xlsx
Introduction: Unscheduled breakthrough-bleeding (spotting) is a common problem in progestin only contraceptive (POC) users. A major feature of POC-endometria is the presence of fragile luminal epithelium (LE), susceptible to shedding/bleeding. We propose that disturbances in Wnt signalling, mediated by signals from the decidualized stroma in POC-endometria, cause LE alterations underlying fragility and bleeding events. Materials & methods: Wnt5a and 7a, β-catenin, E-cadherin and DKK1 were examined by immunohistochemistry in POC- and normal endometrium. Primary human endometrial stromal cells (HESC) were treated with estrogen (10-8M) and progesterone (MPA, 10-7M), both prolactin (PRL) and DKK1 were assessed by ELISA in decidualized (DEC, day 12) versus non-DEC (day 2) media. β-catenin, phospho(P)-β-catenin, APC and Wnt7a localization was examined by immunocytochemistry in recombinant human (rh)-DKK1 treated endometrial epithelial cells (EEC) and P-β-catenin abundance was determined by ...
Sigma-Aldrich offers abstracts and full-text articles by [Kottawattage S A Kottawatta, Kam-Hei So, Suranga P Kodithuwakku, Ernest H Y Ng, William S B Yeung, Kai-Fai Lee].
Decidualization occurs during pregnancy in mammalian species with invasive implantation of the blastocyst. In humans, unlike other species, the process of decidualization is initiated in the second half of the menstrual cycle even in the absence of pregnancy. One of the most obvious features of decudualization is the transformation of stromal cells in the endometrium from a proliferative to a secretory phenotype. The main secretory products include prolactin (PRL) and insulin-like growth factor binding protein-1 (GFBP-1). Decidualization begins in the vicinity of the spiral arteries of the endometrium as early as day 23 of the menstrual cycle, triggered by the rise in cAMP and progesterone. Spontaneous decidualization, or decidualization in the absence of pregnancy, has also been reported in the chimpanzee (Grahm, 1981). Decidualization during pregnancy is very extensive in humans and affects all regions of the uterus.. ...
Definition : Prepackaged collections of the devices and supplies (i.e., either custom or standard kits) needed for sampling procedures intended to obtain endometrium samples for in-vitro tests. Items in these kits usually include a device to take the sample (e.g., a plastic aspirator, a swab), a specimen collector, a slide, a speculum, and anesthetics (e.g., lidocaine). The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Endometrium sampling procedure kits and trays are used to obtain endometrial tissue samples for laboratory analysis in order to diagnose diseases based upon tissue examination. They are used in hospital clinical laboratories, doctors offices, and in other healthcare facilities.. Entry Terms : Endometrial Sampling Kits , Endometrium Sampling Procedure Kit/Trays , ...
Both the upper (endocervix and uterus) and lower (ectocervix and vagina) female genital tract mucosa are considered to be target sites for sexual transmission of HIV. There are a few reports on the T cell and antigen-presenting cell distribution in human endometrial tissue however, there is little known about the expression of the HIV co-receptor CCR5 and HIV-binding C-type lectin receptors on endometrial cell subsets. We therefore assessed endometrial tissue sections from HIV seronegative women undergoing hysterectomy of a benign and non-inflammatory cause for phenotypic characterization of potential HIV target cells and receptors by immunohistochemistry. Langerin was expressed on intraepithelial CD1a+CD4+ and CD11c+CD4+ Langerhans cells. Furthermore, CCR5+CD4+CD3+ T cells, DC-SIGN+MR+CD11c+ myeloid dendritic cells and MR+CD68+ macrophages were found within or adjacent to the epithelium of the uterine lumen. In addition, occasional CD123+BDCA-2+ plasmacytoid dendritic cells were detected deep ...
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Uterine mucosa (endometrium) receptive test helps to assess the receptiveness of the endometrium for embryo implantation. Permits the identification of the so-called personal implantation window, thereby increasing the success rate of embryo transfer.
TY - JOUR. T1 - [Characterization of stem cells in human normal endometrium and endometrial cancer].. AU - Kato, Kiyoko. PY - 2013/2. Y1 - 2013/2. UR - http://www.scopus.com/inward/record.url?scp=84884188307&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84884188307&partnerID=8YFLogxK. M3 - Article. C2 - 23691598. AN - SCOPUS:84884188307. VL - 104. SP - 34. EP - 39. JO - Quaternary International. JF - Quaternary International. SN - 1040-6182. IS - 2. ER - ...
Dr. Carolyn Givens for InfertilityDoctor.com, tells us that one protein produced by the endometrium during the implantation window that has some evidence for a scientific basis for a role in implantation is the cell-to-cell adhesion molecule known as beta-3 integrin. Integrins are a class of cell surface proteins that appear to act in all types of cell-to-cell recognition and adhesion processes. The beta-3 class of these proteins has been shown to be produced in response to progesterone in the endometrium and are purported to be one of the key proteins for adhesion of embryos to the endometrium. Failure to express this protein appropriately has been theorized to be a cause of unexplained implantation failure(1). To simplify, beta-3 integrin is the glue that binds the embryo to the uterine wall for successful implantation in the endometrium (uterine lining). Without this glue, the embryo will not attach properly and could result in miscarriages. ...
Cominelli, Antoine ; Lemoine, Pascale ; Courtoy, Pierre J. ; Tyteca, Donatienne ; Marbaix, Etienne ; et. al. Matrix metalloproteinase-27, an intracellular protease expressed by M2 macrophages in human endometrium and endometriosis.Belgian Society for Cell and Developmental Biology autumn meeting (Antwerpen, Belgium ...
... at which point it naturally separates from the endometrium. Endometrium "Endometrial Cups". Cornell University. June 20, 2014. ...
A thickened endometrium of > 10 mm is usually considered abnormal, though no consensus exists on the appropriate cutoff. A cut- ...
135-. ISBN 978-3-662-08422-9. Gisela Dallenbach-Hellweg (9 March 2013). Histopathology of the Endometrium. Springer Science & ... is incomplete at this dosage and contraceptive effects are instead mainly achieved via progestogenic changes in the endometrium ...
There is no doubt that the conversion of the endometrium with injections of both synthetic and native estrogenic hormone ... G. Dallenbach-Hellweg (6 December 2012). Histopathology of the Endometrium. Springer Science & Business Media. pp. 200-. ISBN ... Neither KAUFMANN (1933, 1935), RAUSCHER (1939, 1942) nor HERRNBERGER (1941) succeeded in bringing a castration endometrium into ... they succeeded in converting an atrophic castration endometrium into an unambiguous proliferation mucosa with 120-300 ...
Endometrium. *Asherman's syndrome. *Dysfunctional uterine bleeding. *Endometrial hyperplasia. *Endometrial polyp. * ...
Endometrium. *Asherman's syndrome. *Dysfunctional uterine bleeding. *Endometrial hyperplasia. *Endometrial polyp. * ...
Endometrium. *Asherman's syndrome. *Dysfunctional uterine bleeding. *Endometrial hyperplasia. *Endometrial polyp. * ...
Endometrium. *Asherman's syndrome. *Dysfunctional uterine bleeding. *Endometrial hyperplasia. *Endometrial polyp. * ...
Endometrium. *Asherman's syndrome. *Dysfunctional uterine bleeding. *Endometrial hyperplasia. *Endometrial polyp. * ...
HMB is associated with increased omega-6 AA in uterine tissues.[8] The endometrium of women with HMB have higher levels of ... Oral progestogen (e.g. norethisterone), to prevent proliferation of the endometrium. *Injected progestogen (e.g. Depo provera) ...
Endometrium. *Asherman's syndrome. *Dysfunctional uterine bleeding. *Endometrial hyperplasia. *Endometrial polyp. * ...
It is encoded by a 1-kilobase-pair mRNA that is expressed in human secretory endometrium and decidua but not in postmenopausal ... PP-14 is the most important protein secreted in the endometrium during the mid-luteal phase of the menstrual cycle and during ... Human endometrium synthesizes several proteins under the influence of progesterone. Of these proteins, placental protein 14 (PP ... It is synthesized by the glandular cells of endometrium in the luteal phase of menstrual cycle. The temporal and spatial ...
EIN may be diagnosed by a trained pathologist by examination of tissue sections of the endometrium. All of the following ... a pathology site focusing on endometrial disease PTEN Gene Cancer Genetics Web PTEN entry PTEN and the Endometrium at PubMed ... certified specialist at the Society of Gynecologic Oncologists Pathology US and Canadian Academy of Pathology www.endometrium. ... Endometrial Precancer Type Collection [On Line]. http://www.endometrium.org 2000. Mutter GL (March 2000). "Endometrial ...
It was recognized in the early 1980s that the addition of a progestogen to estrogen reduced this risk to the endometrium. This ... Feeley, KM; Wells, M (June 2001). "Hormone replacement therapy and the endometrium". Journal of Clinical Pathology. 54 (6): 435 ... due to its proliferative effect on the endometrium. The WHI also found a reduced incidence of colorectal cancer when estrogen ...
There is no doubt that the conversion of the endometrium with injections of both synthetic and native estrogenic hormone ... 2153-. ISBN 978-0-7817-1750-2. Devroey P, Pados G (1998). "Preparation of endometrium for egg donation". Hum. Reprod. Update. 4 ... Neither KAUFMANN (1933, 1935), RAUSCHER (1939, 1942) nor HERRNBERGER (1941) succeeded in bringing a castration endometrium into ... they succeeded in converting an atrophic castration endometrium into an unambiguous proliferation mucosa with 120-300 ...
October 2014). "FOXL2 in human endometrium: hyperexpressed in endometriosis". Reproductive Sciences. 21 (10): 1249-55. doi: ...
... s are a class of tumor characterized by a resemblance to endometrium/ endometrial carcinoma, and over a third ... Endometrioid carcinoma can also arise in the endometrium. Grades 1 and 2 are considered "type 1" endometrial cancer, while ... Light microscopy shows tubular glands, resembling endometrium. Ovarian and endometrial endometrioid carcinomas have distinct ... "Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium". Int. J. Gynecol. Pathol. 27 (1): 49-57. doi: ...
Endometrium Fascia Parametrium "Connective Tissue Study Guide". 2 January 2013. Retrieved 26 October 2014. Dorland, W. A. ...
The endometrium is sloughed off for the next three to six days. Once menstruation ends, the cycle begins again with an FSH ... The endometrium thickens to prepare for implantation, and the ovum travels down the Fallopian tubes to the uterus. If the ovum ... Estrogen thickens the endometrium of the uterus. A surge of Luteinizing Hormone (LH) triggers ovulation. On day 14, the LH ... The uterus has three layers; the innermost layer is the endometrium, where the egg is implanted. During ovulation, this ...
The endometrium after the process of breakdown via the menstruation cycle, re-epithelializes swiftly and regenerates. Though ... Examples of physiological regeneration are the continual replacement of cells of the skin and repair of the endometrium after ... These include the liver, fingertips, and endometrium. More information is now known regarding the passive replacement of ... tissues with a non-interrupted morphology, like non-injured soft tissue, completely regenerate consistently; the endometrium is ...
"Cancer of the Endometrium - Cancer Stat Facts". SEER. Retrieved 2019-11-12. Clinically reviewed uterine cancer information for ... Endometrial stromal sarcomas originate from the connective tissues of the endometrium, and are far less common than endometrial ... Endometrial carcinomas originate from cells in the glands of the endometrium (uterine lining). These include the common and ...
If confined to the endometrium with no myometrial invasion (IA), the prognosis is good with 7-13% recurrence for noninvasive ... Uterine adenosarcoma commonly arise from the endometrium. Uterine adenosarcomas have the highest incidence in perimenopasual ...
Thickens endometrium in females. *Increases catabolism of proteins and carbohydrates[44]. Measurement[edit]. Further ...
Note: UGB is itself progesterone induced gene in the endometrium in Lagomorphs) Inhibits phospholipase A2 in vitro Binds ... 2000). "Expression of uteroglobin in the human endometrium". Mol. Hum. Reprod. 5 (12): 1155-61. doi:10.1093/molehr/5.12.1155. ...
"MUC16 is lost from the uterodome (pinopode) surface of the receptive human endometrium: in vitro evidence that MUC16 is a ... "Proteomic characterization of midproliferative and midsecretory human endometrium." Journal of Proteome Research 8, no. 4 (2009 ...
Hapangama DK, Kamal AM, Bulmer JN (Mar 2015). "Estrogen receptor β: the guardian of the endometrium". Human Reproduction Update ...
... hCG mediates invasion and attachment to the endometrium. Low levels of hCG increase risk of pre-eclampsia. Uterine angiogenesis ... crucial for the maintenance of the endometrium. hCG secreted by cytotrophoblastic cells of the blastocyst controls endometrial ...
The enzyme's expression in the endometrium is raised by a combination of progesterone and transforming growth factor-β1 and ... "Tamoxifen induction of angiogenic factor expression in endometrium". British Journal of Cancer. 86 (5): 761-7. doi:10.1038/sj. ...
Shaw KJ, Ng C, Kovacs BW (1994). "Cyclooxygenase gene expression in human endometrium and decidua". Prostaglandins Leukot. ...
This destroys the endometrium and the nearby growth of dysfunctional smooth muscle. Deeper adenomyosis escapes this coagulative ... Adenomyosis is a medical condition characterized by the growth of cells that build up the inside of the uterus (endometrium) ... The techniques either include physical resection and removal of the endometrium through a hysteroscope, or focus on ablating or ... Circulating Hot Water: Heated water directly introduced into the uterus is used to thermally ablate the endometrium. Microwave ...
Endometrium adalah lapisan terdalam pada rahim dan tempatnya menempelnya ovum yang telah dibuahi. Diperlukan waktu sekitar 4-5 ... Di dalam lapisan Endometrium terdapat pembuluh darah yang berguna untuk menyalurkan zat makanan ke lapisan ini. pembuluh darah ... Saat ovum yang telah dibuahi (yang biasa disebut fertilisasi) menempel di lapisan endometrium (implantasi), maka ovum akan ... hormon progesteron dan berubah menjadi korpus albikan yang menghasilkan sedikit hormon diikuti meluruhnya lapisan endometrium ...
Micrograph of decidualized endometrium due to exogenous progesterone. H&E stain. Micrograph of decidualized endometrium due to ... In a woman of reproductive age, two layers of endometrium can be distinguished. These two layers occur only in the endometrium ... Half of the cases of bacterial vaginitis showed a polymicrobial biofilm attached to the endometrium. The endometrium is the ... The uterus and endometrium was for a long time thought to be sterile. The cervical plug of mucosa was seen to prevent the entry ...
The endometrium and embryo implantation A receptive endometrium depends on more than hormonal influences ... A receptive endometrium depends on more than hormonal influences. *Andrew W Horne, fellow, Medical Research Council, ... In most animals, the endometrium undergoes a series of changes leading to a period of uterine receptivity called the "window of ... The endometrium and embryo implantation. BMJ 2000; 321 doi: https://doi.org/10.1136/bmj.321.7272.1301 (Published 25 November ...
It is widely known that an adequate growth of the endometrium is indispensable for implantation and successful pregnancy. ... Its time to pay attention to the endometrium. Fertil Steril. 2011;96(3):519-21.CrossRefPubMedGoogle Scholar ... Strategies to manage refractory endometrium: state of the art in 2016. Reprod Biomed Online. 2016;32(5):474-89.CrossRefPubMed ... Li R, Hao G. Local injury to the endometrium: its effect on implantation. Curr Opin Obstet Gynecol. 2009;21(3):236-9.CrossRef ...
Histopathology of the Endometrium. Authors. * Gisela Dallenbach-Hellweg Translated by. Dallenbach, F.D.. Copyright. 1987. ...
Ewertz M, Storm HH: Multiple primary cancers of the breast, endometrium and ovary. Eur J Cancer Clin Oncol 25: 1927-1932, 1989 ... Since the prolonged use of estrogen has been reported to increase the rate of benign and malignant changes in the endometrium, ... Patients underwent vaginal ultrasonography and endometrial biopsy in order to evaluate any changes in the endometrium occurring ... On the age-dependent association between cancer of the breast and of the endometrium. A nationwide cohort study. Br J Cancer 55 ...
The health condition known as endometriosis affects 10 to 15 percent of women during their reproductive years. Endometriosis is found globally, and more than 90 million women will suffer from an endometrial condition during their lifetime. Despite the vast numbers of females who are suffering from the symptoms of endometriosis, …. Read More » ...
secretory endometrium synonyms, secretory endometrium pronunciation, secretory endometrium translation, English dictionary ... definition of secretory endometrium. n. pl. en·do·me·tri·a The glandular mucous membrane that lines the uterus. en′do·me′tri·al ... endometrium. (redirected from secretory endometrium). Also found in: Thesaurus, Medical, Encyclopedia. en·do·me·tri·um. (ĕn′dō- ... Results: Of the 101 patients, 53(52.50%) presented with proliferative endometrium, 22(21.80%) had secretory endometrium, 13( ...
SOURCE: Endometrium ( ) Page printed: . Unofficial document if printed. Please refer to SOURCE for latest information. ... Endometrium. Updated May 2018. FIGO Staging. Distribution of patients and approximate Five Year Survival by Surgical Stage/Sub- ... In 1988 FIGO adopted a surgical staging system for cancer of the uterine corpus (Endometrium), which was revised in 2009. ... Non-endometrioid carcinomas are all considered high-risk, even when confined to the endometrium. The only exception is if ...
6 patients with atrophic endometrium experience fatigue, depressed mood, pain, anxious mood, and insomnia. ... Find the most comprehensive real-world symptom and treatment data on atrophic endometrium at PatientsLikeMe. ... What is atrophic endometrium?. The endometrium is the lining of the uterus, an atrophic endometrium is an abnormal thin lining ... 1 a atrophic endometrium patient reports mild depressed mood (100%). * 0 atrophic endometrium patients report no depressed mood ...
... of the endometrium, is most often caused by an excess of estrogen without progesterone, according to the American Congress of O ... Home / World View / What Does It Mean When the Endometrium Is Thick? ... What Does It Mean When the Endometrium Is Thick? By Staff WriterLast Updated Mar 28, 2020 10:29:44 PM ET ... In either scenario, since ovulation does not occur, progesterone is not made, and the endometrium may continue to grow instead ...
Human endometrium expresses a molecular repertoire which includes the heat shock proteins (Hsps) Hsp27, Hsp60, Hsp70, Hsp90, ... Human endometrium, in response to steroid hormones, undergoes characteristic cycles of proliferation, secretory changes, and ... The expression of Hsp27, Hsp60, and the constitutive form of Hsp70 (Hsc70) shows a sharp increase in human endometrium after ... Heat Shock Proteins in Human Endometrium Throughout the Menstrual Cycle. S. Tabibzadeh and J. Broome ...
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. ... Cancer is limited to the endometrium. b. Stage IB:. cancer have penetrated to middle layer of the endometrial linning wall. ... Home , Articles , Health & Fitness , Heart Disease , Most common Types of Cancer - Cancer of Endometrium/Endometrial Cancer ... Most common Types of Cancer - Cancer of Endometrium/Endometrial Cancer By Kyle J. Norton ...
... which occurs when there is proliferation of the endometrium, is progestin therapy, according to the Womens Health and ... What does it mean when the endometrium is thick?. A: Hyperplasia, or thickening, of the endometrium, is most often caused by an ... A: The thickening of the uterine lining or endometrium is a natural occurrence related to menstruation and pregnancy. It can ... The most common treatment for endometrial hyperplasia, which occurs when there is proliferation of the endometrium, is ...
Conditional ablation of BMP-2 in murine endometrium results in complete infertility because BMP-. mice are unable to form ... 3. Fibromatosis, Endometrium, and Endomyometrial Junction. The advances in pathogenetic knowledge of fibroids and the ... S. Matsuzaki, M. Canis, C. Darcha, J. Pouly, and G. Mage, "HOXA-10 expression in the mid-secretory endometrium of infertile ... Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction. Andrea Ciavattini,1 Jacopo Di ...
The Human Endometrium: Studies on Angiogenesis and Endometriosis. Moberg, Christian Uppsala University, Disciplinary Domain of ... The major finding of the study is the high levels of VIP in eutopic and ectopic endometrium, as well as in PF, in our ... The most pronounced VIP expression is seen in endometrium and ectopic lesions from patients with CPP. In addition, we document ... 2. Levels of oestrogen receptor, progesterone receptor and alpha B-crystallin in eutopic endometrium in relation to pregnancy ...
Radiation Oncology/Endometrium/Guidelines. From Wikibooks, open books for an open world ... Retrieved from "https://en.wikibooks.org/w/index.php?title=Radiation_Oncology/Endometrium/Guidelines&oldid=2276518" ...
Endometrium polyps?. Hi everyone.. Im a bit concerned because I went to my gynecologist yesterday and had an ultrasound done. ... He found some polyps in my endometrium. He advised me to do another test to make sure it is nothing to worry about. I wonder if ...
Very Worried , Endometrium Lining Thick I went to my gyno for an ultrasound and sonogram on what they thought were fibroids but ... instead they found out that my endometrium lining was very thick. My gyno wants to do another ultrasound and sonogram just to ...
... will focus on the mechanisms by which P may act to block OXTR signaling and the luteolytic cascade in the ruminant endometrium ... will focus on the mechanisms by which P may act to block OXTR signaling and the luteolytic cascade in the ruminant endometrium ... in the endometrium of ruminant species is regulated by the ovarian steroids progesterone (P) and estradiol (E). Near the end of ... in the endometrium of ruminant species is regulated by the ovarian steroids progesterone (P) and estradiol (E). Near the end of ...
... endometrium explanation free. What is endometrium? Meaning of endometrium medical term. What does endometrium mean? ... Looking for online definition of endometrium in the Medical Dictionary? ... endome´tria the mucous membrane lining the uterus.. endometrium. (ĕn′dō-mē′trē-əm). n. pl. endome·tria (-trē-ə) The glandular ... Related to endometrium: endometrioma, Endometrial hyperplasia. endometrium. [en″do-me´tre-um] (pl. endome´tria) (Gr.) the ...
Laparoscopic Approach to Cancer of the Endometrium. The safety and scientific validity of this study is the responsibility of ... Endometrium. Uterus. Cancer. Carcinoma. Adenocarcinoma. Stage 1. Laparoscopy. Abdominal. Total. Surgery. Quality of Life. ... LACE - Laparoscopic Approach to Cancer of the Endometrium: An International Multicenter Randomized Phase 3 Clinical Trial. ...
Radiation Oncology/Endometrium/Early Stage. From Wikibooks, open books for an open world ... See also at: Radiation Oncology/Endometrium/Recurrence. *8-year outcome: LRF: RT 4% vs. control 15% (SS), majority failures ... Retrieved from "https://en.wikibooks.org/w/index.php?title=Radiation_Oncology/Endometrium/Early_Stage&oldid=3704245" ...
Hormonal Effects on the Uterus and Endometrium. The safety and scientific validity of this study is the responsibility of the ... Endometrium is the lining of the uterus. It is where the fertilized egg normally implants during pregnancy. ... The mechanism(s) by which estrogen and progesterone exert these effects on the endometrium is not known. This is a tissue ... This tissue will be used for future studies intended to understand gonadal steroid action on the endometrium We propose to ...
We previously reported cyclic changes of lymphatic vessels in human endometrium using D2-40. Design: A total of 16 cases ... Objective: Using cryosections of human endometrium, this study aimed to unveil possible cyclic changes of lymphatic and venous ... In Day 5 - 9 endometrium, there were sparse lymphatic vessels but were numerous growing venous vessels in thin proliferating ... In Day 14 - 22 endometrium, there were scattered lymphatic vessels and numerous venous vessels in functionalis. In Day 25 - 26 ...
The primary stromal endometrium cells were immortalized by infection with supernatant from the packaging cell line pA317-hTERT ... This endometrium cell line was derived from the stromal cells obtained from an adult female with myomas. ... The primary stromal endometrium cells were immortalized by infection with supernatant from the packaging cell line pA317-hTERT ... This endometrium cell line was derived from the stromal cells obtained from an adult female with myomas. ...
He found some polyps in my endometrium. He advised me ... He found some polyps in my endometrium. He advised me to do ...
We found that LPA and PCSK5 site mutations were common to eutopic endometria and endometriosis lesions in 66.7% (12/18) of the ... Home , May 5, 2019 - Volume 132 - Issue 9 , Pathogenetic gene changes of eutopic endometrium in patients... ... There was no overlap among the mutation sites of ectopic lesions and eutopic endometria of the above patients as well as those ... In this study, WES was used to sequence and analyze the ectopic endometrium and OEM tissues of OEM patients. Ten genes of ...
Mink Uterus Endometrium Epithelial Cells (GMMe Line). The culture of mink endometrial (GMMe) cells presented in the digital ...
Learn about conditions that impact the endometrium and your fertility. ... What is the endometrium, how does it work, and what happens when things go wrong? ... How the Endometrium Works The uterus is made up of three layers: the serosa, the myometrium, and the endometrium. The serosa is ... The endometrium is the inner lining of the uterus. Each month, the endometrium thickens and renews itself, preparing for ...

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