Endometrium
Menstrual Cycle
The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.
Endometriosis
Endometrial Neoplasms
Endometrial Hyperplasia
Uterus
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
Decidua
The hormone-responsive glandular layer of ENDOMETRIUM that sloughs off at each menstrual flow (decidua menstrualis) or at the termination of pregnancy. During pregnancy, the thickest part of the decidua forms the maternal portion of the PLACENTA, thus named decidua placentalis. The thin portion of the decidua covering the rest of the embryo is the decidua capsularis.
Menstruation
Pregnancy
Progesterone
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Pregnancy, Animal
Luteal Phase
Pregnancy Proteins
Stromal Cells
Immunohistochemistry
Estrous Cycle
Endometritis
Uterine Hemorrhage
Estradiol
Levonorgestrel
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Metrorrhagia
Pseudopregnancy
Contraceptive Agents, Female
Receptors, Progesterone
Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.
Estrus
Polyps
Carcinoma, Endometrioid
Macaca radiata
Fallopian Tubes
A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.
Medroxyprogesterone Acetate
Mifepristone
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
Follicular Phase
Placentation
The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.
Dinoprost
Gonanes
Progestins
Estrogens
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Epithelium
Trophoblasts
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
Receptors, Oxytocin
Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.
Progesterone Congeners
Hormone Antagonists
Sheep
Papio
A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.
Reverse Transcriptase Polymerase Chain Reaction
In Situ Hybridization
Dilatation and Curettage
Papio anubis
Placenta
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
Oxytocin
Gene Expression
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Insulin-Like Growth Factor Binding Protein 1
One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)
Gene Expression Regulation
Adenomyosis
Leiomyoma
Receptors, Estrogen
Medroxyprogesterone
Danazol
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Blastocyst
A post-MORULA preimplantation mammalian embryo that develops from a 32-cell stage into a fluid-filled hollow ball of over a hundred cells. A blastocyst has two distinctive tissues. The outer layer of trophoblasts gives rise to extra-embryonic tissues. The inner cell mass gives rise to the embryonic disc and eventual embryo proper.
Postmenopause
Biopsy
Leukemia Inhibitory Factor
Interferon Type I
Genitalia, Female
Culture Techniques
Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types.
Ovary
The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
Production of prostaglandin f2alpha and its metabolite by endometrium and yolk sac placenta in late gestation in the tammar wallaby, Macropus Eugenii. (1/3697)
In this study, we investigated production of prostaglandin (PG) F2alpha and its metabolite, PGFM, by uterine tissues from tammar wallabies in late pregnancy. Endometrial explants were prepared from gravid and nongravid uteri of tammars between Day 18 of gestation (primitive streak) and Day 26.5 (term) and were incubated in Ham's F-10 medium supplemented with glutamine and antibiotics for 20 h. PGF2alpha and PGFM in the medium were assayed by specific, validated RIAs. Control tissues (leg muscle) did not produce detectable amounts of either PG. Both gravid and nongravid endometria secreted PGF2alpha, and production increased significantly in both gravid and nongravid uteri towards term. PGFM was produced in small amounts by both gravid and nongravid uteri, and the rate of production did not increase. Neither oxytocin nor dexamethasone stimulated PG production in vitro in any tissue at any stage. Thus, the surge in peripheral plasma PGFM levels seen at parturition may arise from increased uterine PG production, but further study is needed to define what triggers this release. (+info)Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. (2/3697)
Trophinin, tastin, and bystin comprise a complex mediating a unique homophilic cell adhesion between trophoblast and endometrial epithelial cells at their respective apical cell surfaces. In this study, we prepared mouse monoclonal antibodies specific to each of these molecules. The expression of these molecules in the human placenta was examined immunohistochemically using the antibodies. In placenta from the 6th week of pregnancy, trophinin and bystin were found in the cytoplasm of the syncytiotrophoblast in the chorionic villi, and in endometrial decidual cells at the utero placental interface. Tastin was exclusively present on the apical side of the syncytiotrophoblast. Tissue sections were also examined by in situ hybridization using RNA probes specific to each of these molecules. This analysis showed that trophoblast and endometrial epithelial cells at the utero placental interface express trophinin, tastin, and bystin. In wk 10 placenta, trophinin and bystin were found in the intravillous cytotrophoblast, while tastin was not found in the villi. After wk 10, levels of all three proteins decreased and then disappeared from placental villi. (+info)Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-tau in bovine endometrial cells. (3/3697)
Oxytocin (OT) is responsible for the episodic release of luteolytic prostaglandin (PG) F2alpha from the uterus in ruminants. The attenuation of OT-stimulated uterine PGF2alpha secretion by interferon-tau (IFN-tau) is essential for prevention of luteolysis during pregnancy in cows. To better understand the mechanisms involved, the effect of recombinant bovine IFN-tau (rbIFN-tau) on OT-induced PG production and cyclooxygenase-2 (COX-2) and PGF synthase (PGFS) expression in cultured endometrial epithelial cells was investigated. Cells were obtained from cows at Days 1-3 of the estrous cycle and cultured to confluence in RPMI medium supplemented with 5% steroid-free fetal calf serum. The cells were then incubated in the presence or absence of either 100 ng/ml OT or OT+100 ng/ml rbIFN-tau for 3, 6, 12, and 24 h. OT significantly increased PGF2alpha and PGE2 secretion at all time points (p < 0.01), while rbIFN-tau inhibited the OT-induced PG production and reduced OT receptor binding in a time-dependent manner. OT increased the steady-state level of COX-2 mRNA, measured by Northern blot, which was maximal at 3 h (9-fold increase) and then decreased with time (p < 0.01). OT also caused an increase in COX-2 protein, which peaked at 12 h (11-fold increase), as measured by Western blot. Addition of rbIFN-tau suppressed the induction of COX-2 mRNA (89%, p < 0.01) and COX-2 protein (50%, p < 0.01) by OT. OT also increased PGFS mRNA, and this stimulation was attenuated by rbIFN-tau (p < 0.01). To ensure that the decrease in COX-2 was not solely due to down-regulation of the OT receptor, cells were stimulated with a phorbol ester (phorbol 12-myristate 13-acetate; PMA) in the presence and absence of rbIFN-tau. The results showed that rbIFN-tau also decreased PMA-stimulated PG production and COX-2 protein. It can be concluded that rbIFN-tau inhibition of OT-stimulated PG production is due to down-regulation of OT receptor, COX-2, and PGFS. (+info)Molecular and cellular aspects of endometrial receptivity. (4/3697)
Endocrine and paracrine controls regulate the endometrium during the luteal phase of the cycle to permit implantation. Part of this differentiation process is the production of a specific secretion which fills the intrauterine cavity and glandular lumen. Its molecular composition originates from the gland secretion, from transudations from stroma, from the endometrial blood vessels, and last, but not least, from cellular components of apoptotic and exfoliated cells. We have studied the secretions of all phases during the menstrual cycle using patterns evaluated by SDS-PAGE, by laser densitometry or Western blots. Uterine secretion electrophoresis (USE) permits detailed analyses of the intrauterine micromilieu and allows clinical assessment of the receptive stage of endometrium during the luteal phase. Several individual protein bands have been defined as characteristic markers for such receptive pattern. We have isolated and identified the molecular structure of several of these proteins, e.g. histones, cyclophilin, transthyretin, haptoglobin and uteroglobin. Investigations on the endocrine regulation of these proteins, were carried out on the uterine secretions of patients treated with progesterone antagonists (mifepristone and onapristone). The results demonstrate how progesterone-dependent components produce a receptive pattern, which can serve as a useful and precise marker in the clinical diagnosis of the luteal phase. Essential progesterone-dependent components differentiating during the luteal phase may provide new targets for contraceptive interventions by preventing the physiological changes typical of receptivity. (+info)Molecular control of the implantation window. (5/3697)
Human endometrium is the end organ of the hypothalamic-pituitary-ovarian axis. Therefore, endometrium is susceptible to changes in the cases of infertility that originate from disturbances in the normal functioning of this axis. In addition, some cases of unexplained infertility may be due to altered endometrial function. This disturbed endometrial function may originate from lesions in the molecular repertoire that are crucial to implantation. Human endometrium becomes receptive to implantation by the blastocyst within a defined period during the menstrual cycle. The duration of this so-called 'endometrial receptivity' or 'implantation' period seems to span from few days after ovulation to several days prior to menstruation. Successful implantation results from a co-ordinated series of events that would allow establishment of a timely dialogue between a receptive endometrium and an intrusive blastocyst. The members of the molecular repertoire that make endometrium receptive to implantation are gradually being recognized. Among these are the cytokines, integrins, heat shock proteins, tastin and trophinin. In addition, the expression of a second set of genes including tumour necrosis factor alpha (TNF-alpha) and ebaf, may be the appropriate signal for the closure of the 'implantation window', for making the endometrium refractory to implantation and for preparing it for the menstrual shedding. (+info)Marker genes of decidualization: activation of the decidual prolactin gene. (6/3697)
Decidualization of human endometrial stromal (ES) cells in vitro is induced by cAMP analogues and ligands that elevate cellular cAMP levels in a manner resembling the gonadotrophins, prostaglandin E2 and relaxin (RLX). This differentiation process is marked by the onset of decidual prolactin (PRL) production in the late luteal phase of the cycle. Using transfection assays and a primary ES cell culture system, we have demonstrated that decidual PRL gene transcription is driven by an alternative upstream promoter (dPRL), approximately 6 kb upstream of the pituitary transcription start site. In primary cell cultures, RLX not only acutely but also permanently elevated cellular cAMP levels and induced PRL secretion after 6 days. Northern and Western blot analyses revealed all regulatory subunit isoforms (RIalpha, RIbeta, RIIalpha, RIIbeta) and catalytic subunits Calpha and Cbeta of protein kinase A (PKA) in ES cells. Transcript levels of PKA subunit isoforms are not altered during decidualization, but in decidualized ES cells exposed to elevated cellular cAMP levels by stimulation with RLX for >6 days, RIalpha protein levels were significantly reduced, whereas levels of all other forms remained unchanged. Reducing the availability of R subunits changed the R:C subunit ratio in favour of C and increased kinase activity. In transient transfections of undifferentiated ES cells, the dPRL promoter was activated by 8-Br-cAMP and by C subunit (Cbeta) of PKA. This induction, and the differentiation-dependent activity of the dPRL promoter in transfected decidualized cells, was effectively abolished by the co-expression of protein kinase inhibitor (PKI). A fragment of 332 bp of 5'-flanking region of the dPRL transcription start site was sufficient to mediate full inducibility by cAMP. cAMP activation of the dPRL promoter in ES cells was biphasic as an initial weak induction within 12 hours was followed by a subsequent, much more intense induction after 12 hours. The secondary induction was not seen with a control construct driven by a consensus cAMP response element (CRE) linked to a minimal promoter. The early response of the dPRL promoter depended upon a non-palindromic CRE at position -12 and mutation of this sequence led to omission of the early, but not of the delayed, induction. The major activation of the dPRL promoter depended upon a different region between position -332 and -270 since its deletion significantly reduced inducibility by cAMP. Its action was probably indirect as its kinetics differed from classic CRE-mediated responses, and it was specific to ES cells. (+info)Changes in basement membrane thickness in the human endometrium during the luteal phase of the menstrual cycle. (7/3697)
We have examined aspects of the fine structure of the basal laminae associated with the luminal and glandular epithelium and small blood vessels in the human endometrium. Four short studies are presented and reviewed. Study 1 examined biopsies from 20 fertile women taken on days after the luteinizing hormone surge (LH): LH +2, 4, 6, 8 and 10. The basal lamina (both lamina densa and lucida) increased in thickness over the period studied. Study 2 again studied the glandular epithelium and examined the effect of RU486 (a progesterone receptor blocker) administered on day LH +3 and biopsied on day LH +6. The basal laminae were found to be the same as LH +2 control group but thinner than LH +6 control. Study 3 documented increased thickness of the basal laminae between LH +6, 8 and 13 in the luminal epithelium. The within-group coefficient of variation was 16% and 27% for LH +6 and LH +13 groups but only 2 % for LH +8. Study 4 demonstrated an increase in basal lamina thickness associated with small blood vessels between LH +6 and LH +10 in normal fertile women. The basal lamina provides the interface between epithelial and mesenchymal environments; changes in its structure can alter the phenotypic expression of the epithelia. It is one of the maternal barriers that must be transgressed by the trophoblast during implantation. Together, these combined studies provide quantitative baseline structural information on the electron microscopical appearance of the basal lamina during the luteal phase of the menstrual cycle. (+info)Endometrial microvascular growth in normal and dysfunctional states. (8/3697)
As a tissue that exhibits rapid cyclical growth and shedding throughout the reproductive life of the female, human endometrium provides a good model for the study of normal physiological angiogenesis. The objective of this paper is to summarize recent data on endometrial vascular growth, present new data on regional variability in endothelial cell proliferation within the endometrium, and interpret this information in light of current knowledge of the mechanisms by which angiogenesis occurs. Conventional angiogenesis normally involves a series of steps which include endothelial cell activation, breakdown of the basement membrane, migration and proliferation of the endothelial cell, fusion of sprouts, and tube formation. Other mechanisms by which angiogenesis occurs include intussusception and vessel elongation. Using immunohistochemical techniques we have shown repeatedly that levels of endothelial cell proliferation within human endometrium do not show any consistent pattern across the different stages of the menstrual cycle, which is unexpected since significant vascular growth must occur during the proliferative phase, when the endometrium increases in thickness by up to 4-fold. There are two possible explanations for this; either there is no obligatory link between endometrial endothelial cell proliferation and new vessel formation, or there is significant variation in endothelial cell proliferation within different regions of the same uterus. Multiple samples from hysterectomy specimens subsequently demonstrated that the variability is due to real differences between individuals, as well as showing that the endothelial cell proliferation index is significantly elevated in functionalis compared with basalis. During these studies we observed that endothelial cell proliferation nearly always appeared inside existing endometrial vessels, rather than be associated with structures that could be identified as vascular sprouts. To explore further whether sprout formation occurs during endometrial angiogenesis, we investigated the immunohistochemical distribution of integrin alphavbeta3 on endometrial endothelial cells. As for endothelial cell proliferation, integrin alphavbeta3 immunostaining was seen only on endothelial cells that appeared within existing blood vessels. The results from these studies have major implications for our understanding of the mechanisms that control endometrial angiogenesis. The lack of correlation between menstrual cycle stage and endothelial cell proliferation index, or endothelial cell expression of integrin alphavbeta3, suggests that vascular growth is not under the overall control of oestrogen and progesterone. (+info)Differences in lectin binding patterns of normal human endometrium between proliferative and secretory phases<...
Secretory endometrium - definition of secretory endometrium by The Free Dictionary
Effects of bisphenol A on human endometrial endothelial cell angiogenic activity in vitro
The Endometrial Cycle - Menstrual Cycle - Flanders Health Blog
Transvaginal endometrial perfusion of granulocyte colony-stimulating factor for infertile women with thin endometrium in frozen...
Global Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis<...
Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first...
Effects of progesterone administered by nasal spray on the human postmenopausal endometrium | IRIS Univ. Bari
Uterus, early proliferative phase | Kenhub
Endometrial cycle | Article about Endometrial cycle by The Free Dictionary
Inhibition of Histone Deacetylase Activity in Human Endometrial Stromal Cells Promotes Extracellular Matrix Remodelling and...
A Two-Cohort RNA-seq Study Reveals Changes in Endometrial and Blood miRNome in Fertile and Infertile Women
Secretory endometrium - Endometrium - MyPathologyReport.ca
The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase...
Paracrine regulation of matrix metalloproteinase expression in the normal human endometrium - GeoScience.net
Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium<...
British Library EThOS: Characterization of the endometrium of women with reproductive failure
Uterus and endometrium: Regeneration processes in rabbit endometrium: a photodynamic therapy model - Zurich Open Repository...
Hormonal Effects on the Uterus and Endometrium - Full Text View - ClinicalTrials.gov
Contribution of Bone Marrow-Derived Stem Cells to Endometrium and Endometriosis - Du - 2007 - STEM CELLS - Wiley Online Library
The mutational landscape of normal human endometrial epithelium | Nature
Implantation in the baboon: Endometrial responses<...
Inflammosome in the human endometrium: further step in the evaluation of the maternal side<...
Failed IVF | Health24
ReP USP - Detalhe do registro: Characterization of the endometrial gene expression profile on day 7 post-estrus in response to...
Molecular identification of latent precancers in histologically normal endometrium<...
Endometrium - Wikipedia
Endometrial stromal cells: isolation, expansion, morphological and functional properties | Experimental oncology
Endometrial receptivity/Fertilitypedia
Dating secretory endometrium - 10 Great Places To Meet The Man
Androgen signaling in decidualizing human endometrial stromal cells enhances resistance to oxidative stress - Fertility...
Isolation of viruses from cultures of bovine endometrial cells. - Immunology
Dr.Malpanis Blog: July 2009
Matrix Metalloproteinase-27 is expressed in CD163+/CD206+ macrophages in the human endometrium and in endometriotic lesions
|...
Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol | Journal of Animal...
ovarian endometrium
Papers with the keyword uterobrush,endometrial | Read by QxMD
The effect of endometrial thickness and pattern measured by ultrasonography on pregnancy outcomes during IVF-ET cycles |...
Table 5 Differential microRNA Expression in Porcine Endometrium Involved in Remodeling and Angiogenesis That Contributes to...
Oral Presentation - ASN Events
MicroRNA-212 Regulates the Expression of Olfactomedin 1 and C-Terminal Binding Protein 1 in Human Endometrial Epithelial Cells...
Timing of Decidual Changes in Endometrium | Center for Academic Research and Training in Anthropogeny (CARTA)
procedure-kit-trays-sampling-endometrium
Detection of Intraepithelial and Stromal Langerin and CCR5 Positive Cells in the Human Endometrium : Potential Targets for HIV...
Best trans cervical resection of endometrium specialists in Sector 78, Noida - Book Appointment Online | Credihealth
Endometrium Hashag Endometrium Black Hand Printed T shirt | Fruugo
Uterine mucosa (endometrium) receptive test | Ida-Tallinna Keskhaigla
Characterization of stem cells in human normal endometrium and endometrial cancer]. - Kyushu University
Sweet Pea - My TTC Journey: Endometrial Biopsy Results
Matrix metalloproteinase-27, an intracellular protease expressed by M2 macrophages in human endometrium and endometriosis
|...
Endometrium
Micrograph of decidualized endometrium due to exogenous progesterone. H&E stain. Micrograph of decidualized endometrium due to ... Half of the cases of bacterial vaginitis showed a polymicrobial biofilm attached to the endometrium. The endometrium is the ... The uterus and endometrium was for a long time thought to be sterile. The cervical plug of mucosa was seen to prevent the entry ... The endometrium consists of a single layer of columnar epithelium plus the stroma on which it rests. The stroma is a layer of ...
Anordrin
Stanley R. Glasser; John D. Aplin; Linda C. Giudice; Siamak Tabibzadeh (14 January 2004). The Endometrium. CRC Press. pp. 711 ...
Endometrial cup
... at which point it naturally separates from the endometrium. Endometrium "Endometrial Cups". Cornell University. June 20, 2014. ...
Products of conception
A thickened endometrium of > 10 mm is usually considered abnormal, though no consensus exists on the appropriate cutoff. A cut- ...
Chlormadinone acetate
135-. ISBN 978-3-662-08422-9. Gisela Dallenbach-Hellweg (9 March 2013). Histopathology of the Endometrium. Springer Science & ... is incomplete at this dosage and contraceptive effects are instead mainly achieved via progestogenic changes in the endometrium ...
Diethylstilbestrol dipropionate
There is no doubt that the conversion of the endometrium with injections of both synthetic and native estrogenic hormone ... G. Dallenbach-Hellweg (6 December 2012). Histopathology of the Endometrium. Springer Science & Business Media. pp. 200-. ISBN ... Neither KAUFMANN (1933, 1935), RAUSCHER (1939, 1942) nor HERRNBERGER (1941) succeeded in bringing a castration endometrium into ... they succeeded in converting an atrophic castration endometrium into an unambiguous proliferation mucosa with 120-300 ...
Connective tissue
Endometrium Parametrium Biga, Lindsay M.; Dawson, Sierra; Harwell, Amy (26 September 2019). "4.1 Types of Tissues". Retrieved ...
Endometrial intraepithelial neoplasia
EIN may be diagnosed by a trained pathologist by examination of tissue sections of the endometrium. All of the following ... American Cancer Society OncoLink an educational site from the U. of Pennsylvania www.endometrium.org a pathology site focusing ... on endometrial disease PTEN Gene Cancer Genetics Web PTEN entry PTEN and the Endometrium at PubMed Entrez Gene PTEN entry ( ... Endometrial Precancer Type Collection [On Line]. http://www.endometrium.org 2000. Mutter GL (March 2000). "Endometrial ...
Glycodelin
GD is the most important protein secreted in the endometrium during the mid-luteal phase of the menstrual cycle and during the ... It is encoded by a 1-kilobase-pair mRNA that is expressed in human secretory endometrium and decidua but not in postmenopausal ... Human endometrium synthesizes several proteins under the influence of progesterone. Of these proteins, glycodelin is of ... Horne CH, Paterson WF, Sutcliffe RG (Jul 1982). "Localization of alpha-uterine protein in human endometrium". Journal of ...
Hormone replacement therapy
It was recognized in the early 1980s that the addition of a progestogen to estrogen reduced this risk to the endometrium. This ... Feeley, KM; Wells, M (June 2001). "Hormone replacement therapy and the endometrium". Journal of Clinical Pathology. 54 (6): 435 ... due to its proliferative effect on the endometrium. The WHI also found a reduced incidence of colorectal cancer when estrogen ...
Estradiol valerate
There is no doubt that the conversion of the endometrium with injections of both synthetic and native estrogenic hormone ... 2153-. ISBN 978-0-7817-1750-2. Devroey P, Pados G (1998). "Preparation of endometrium for egg donation". Hum. Reprod. Update. 4 ... Neither KAUFMANN (1933, 1935), RAUSCHER (1939, 1942) nor HERRNBERGER (1941) succeeded in bringing a castration endometrium into ... they succeeded in converting an atrophic castration endometrium into an unambiguous proliferation mucosa with 120-300 ...
FOXL2
October 2014). "FOXL2 in human endometrium: hyperexpressed in endometriosis". Reproductive Sciences. 21 (10): 1249-55. doi: ...
Human sexuality
The endometrium is sloughed off for the next three to six days. Once menstruation ends, the cycle begins again with an FSH ... The endometrium thickens to prepare for implantation, and the ovum travels down the Fallopian tubes to the uterus. If the ovum ... Estrogen thickens the endometrium of the uterus. A surge of Luteinizing Hormone (LH) triggers ovulation. On day 14, the LH ... The uterus has three layers; the innermost layer is the endometrium, where the egg is implanted. During ovulation, this ...
Regeneration in humans
The endometrium after the process of breakdown via the menstruation cycle, re-epithelializes swiftly and regenerates. Though ... Examples of physiological regeneration are the continual replacement of cells of the skin and repair of the endometrium after ... These include the liver, fingertips, and endometrium. More information is now known regarding the passive replacement of ... tissues with a non-interrupted morphology, like non-injured soft tissue, completely regenerate consistently; the endometrium is ...
Uterine cancer
"Cancer of the Endometrium - Cancer Stat Facts". SEER. Retrieved 2019-11-12. Felix AS, Brinton LA (September 2018). "Cancer ... Endometrial stromal sarcomas originate from the connective tissues of the endometrium, and are far less common than endometrial ... Endometrial carcinomas originate from cells in the glands of the endometrium (uterine lining). These include the common and ...
Adenosarcoma
If confined to the endometrium with no myometrial invasion (IA), the prognosis is good with 7-13% recurrence for noninvasive ... Uterine adenosarcoma commonly arise from the endometrium. Uterine adenosarcomas have the highest incidence in perimenopausal ...
Uteroglobin
Note: UGB is itself progesterone induced gene in the endometrium in Lagomorphs) Inhibits phospholipase A2 in vitro Binds ... 2000). "Expression of uteroglobin in the human endometrium". Mol. Hum. Reprod. 5 (12): 1155-61. doi:10.1093/molehr/5.12.1155. ...
Plasma membrane transformation
"MUC16 is lost from the uterodome (pinopode) surface of the receptive human endometrium: in vitro evidence that MUC16 is a ... "Proteomic characterization of midproliferative and midsecretory human endometrium." Journal of Proteome Research 8, no. 4 (2009 ...
Estrogen receptor beta
Hapangama DK, Kamal AM, Bulmer JN (Mar 2015). "Estrogen receptor β: the guardian of the endometrium". Human Reproduction Update ...
Endometrioid tumor
... s are a class of tumor characterized by a resemblance to endometrium/ endometrial carcinoma, and over a third ... Endometrioid carcinoma can also arise in the endometrium. Grades 1 and 2 are considered "type 1" endometrial cancer, while ... resembling endometrium. Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN gene mutation profiles. ... "Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium". Int. J. Gynecol. Pathol. 27 (1): 49-57. doi: ...
Endocrinology of reproduction
... hCG mediates invasion and attachment to the endometrium. Low levels of hCG increase risk of pre-eclampsia. Uterine angiogenesis ... crucial for the maintenance of the endometrium. hCG secreted by cytotrophoblastic cells of the blastocyst controls endometrial ...
Organ-on-a-chip
The endometrium has been modeled for its role in implantation and other stages of pregnancy. Researchers are working towards ... "Three-dimensional microengineered vascularised endometrium-on-a-chip". Hum Reprod. 36 (10): 2720-2731. doi:10.1093/humrep/ ...
Hyperprolactinaemia
"Physiology of the Endometrium and Regulation of Menstruation". Physiological Reviews. 100 (3): 1149-1179. doi:10.1152/physrev. ...
Organoid
Rawlings TM, Makwana K, Tryfonos M, Lucas ES (July 2021). "Organoids to model the endometrium: implantation and beyond". Reprod ...
Thymidine phosphorylase
The enzyme's expression in the endometrium is raised by a combination of progesterone and transforming growth factor-β1 and ... "Tamoxifen induction of angiogenic factor expression in endometrium". British Journal of Cancer. 86 (5): 761-7. doi:10.1038/sj. ...
Implantation (embryology)
As part of the organ-on-a-chip program, an endometrium-on-a-chip has been developed to model the functioning of the endometrium ... The endometrium increases thickness, becomes vascularized and its glands grow to be tortuous and boosted in their secretions. ... By the end of the first week the blastocyst is superficially attached to the uterine endometrium. By the end of the second week ... Apposition is usually made where there is a small crypt in the endometrium, and also where there has been enough breakdown of ...
Arachidonate 5-lipoxygenase
Shaw KJ, Ng C, Kovacs BW (1994). "Cyclooxygenase gene expression in human endometrium and decidua". Prostaglandins Leukot. ...
Adenomyosis
In endometriosis, the tissue is similar to, but not the same as, the endometrium. The two conditions are found together in many ... This destroys the endometrium and the nearby growth of dysfunctional smooth muscle. Deeper adenomyosis escapes this coagulative ... The techniques either include physical resection and removal of the endometrium through a hysteroscope, or focus on ablating or ... Circulating Hot Water: Heated water directly introduced into the uterus is used to thermally ablate the endometrium. Microwave ...
In vitro fertilisation
Timeva T, Shterev A, Kyurkchiev S (October 2014). "Recurrent implantation failure: the role of the endometrium". Journal of ...
Estrogen (medication)
There is no doubt that the conversion of the endometrium with injections of both synthetic and native estrogenic hormone ... Unopposed estrogen therapy stimulates the growth of the endometrium and is associated with a dramatically increased risk of ... Neither KAUFMANN (1933, 1935), RAUSCHER (1939, 1942) nor HERRNBERGER (1941) succeeded in bringing a castration endometrium into ... Progestogens prevent the effects of estrogens on the endometrium. As a result, they are able to completely block the increase ...
Comparative metabolism of blastocysts, extraembryonic membranes, and uterine endometrium of the mouse
Browsing by Subject "Endometrium"
Abnormally thick endometrium - Cancer Survivors Network
My Endometrium bipsy is tomorrow and I am very nervous. I am hopeful they will get the proper samples. If not its on to D&C. I ... My Endometrium bipsy is tomorrow and I am very nervous. I am hopeful they will get the proper samples. If not its on to D&C. I ... My Endometrium bipsy is tomorrow and I am very nervous. I am hopeful they will get the proper samples. If not its on to D&C. I ... My endometrium is at 1.5 cm or 15 mm. the two probable fibroids are located in the myometrium and the cyst is in the right ...
The development of adenocarcinoma of the endometrium in young women receiving long-term sequential oral contraception
PIP: 4 cases of adenocarcinoma of the endometrium were reported in young women. All were using and had used for periods of 4-12 ... The development of adenocarcinoma of the endometrium in young women receiving long-term sequential oral contraception Am J ... A study is now in progress to determine whether long-term use of Oracon produces premalignant changes in the endometrium. ...
The Endometrium | Journal of Clinical Pathology
Frontiers | Platelet-Rich Plasma as a Potential New Strategy in the Endometrium Treatment in Assisted Reproductive Technology
Growing evidence correlates the effect of intrauterine platelet-rich plasma (PRP) infusion on the endometrium with reassuring ... Growing evidence correlates the effect of intrauterine platelet-rich plasma (PRP) infusion on the endometrium with reassuring ... Thin Endometrium. Endometrium is one of the most prominent factors in implantation and pregnancy. Multiple studies suggest that ... For the patients with thin endometrium, the timing of PRP infusion varied from the 8th day to the 17th day of HRT cycle, and ...
Obesity and the Endometrium: Adipocyte-Secreted Proinflammatory TNFα Cytokine Enhances the Proliferation of Human Endometrial...
Obesity and the Endometrium: Adipocyte-Secreted Proinflammatory TNFα Cytokine Enhances the Proliferation of Human Endometrial ... Another potential procancerous effect of TNFα is via modulating estrogen effects on endometrium. We have recently reported the ... and endometrium, are believed to be associated with increase in body weight and low physical activity [5]. Numerous studies ... and has been associated with physiological and pathological changes in the endometrium-like remodeling, implantation, and ...
endometrium - Humpath.com - Human pathology
Morphologically, the endometrium is one of the most dynamic target tissues in women. Its cyclic structural changes mirror ... Because of this interplay of structure, function, and ovarian hormonal stimuli, the endometrium is considered one of the most ... endometrium.org at Womens and Perinatal Pathology, Brigham and Womens Hospital, Boston, MA ... As a result, morphologic evaluation of the endometrium is used in diagnostic evaluation of infertile patients to determine ...
Tissue expression of MIPEP - Staining in endometrium - The Human Protein Atlas
... in endometrium tissue. Antibody staining with HPA030676, HPA031669 and HPA031670 in immunohistochemistry. ... TISSUE PRIMARY DATA ENDOMETRIUM ADIPOSE TISSUE ADRENAL GLAND AMYGDALA APPENDIX BASAL GANGLIA BONE MARROW BREAST BRONCHUS ... ENDOMETRIUM - Expression summary. Protein expression. Endometriumi On the top, protein expression in current human tissue, ... CEREBELLUM CEREBRAL CORTEX CERVIX CHOROID PLEXUS COLON DUODENUM ENDOMETRIUM EPIDIDYMIS ESOPHAGUS FALLOPIAN TUBE GALLBLADDER ...
Why Does a Thin Endometrium Lower Embryo Implantation?
A thin endometrium often results in lower embryo implantation. There are several theories on why this occurs. ... For successful implantation to occur, an embryo needs a "receptive" uterine lining (endometrium). A thin endometrium can result ... Why Does a Thin Endometrium Lower Embryo Implantation?. Dr. Vishvanath Karande Dec 06 329 Comments ... In the endometrium, when the thickness measured by ultrasound is ,7 mm, it is the functional layer that is thin or absent, and ...
Amino acid transporter expression in the endometrium and conceptus membranes during early equine pregnancy
Normal conceptuses and endometrium ... read more were recovered on Days 7, 14, 21 and 28 after ovulation. To investigate ... Because conceptuses express a wider range of transporters than the endometrium, we speculate that the equine yolk sac has ... Amino acid transporter expression in the endometrium and conceptus membranes during early equine pregnancy. DSpace/Manakin ... In the present study we investigated AA transporter expression in early equine conceptuses and endometrium, during normal ...
p53 and bcl-2 Expression in Invasive and Pre-invasive Uterine Papillary Serous Carcinoma and Atrophic Endometrium - Annals...
Results: p53 was identified in 16/21 cases of UPSC (76%) and 8/9 cases of IEN (89%), and no cases of normal endometrium. By ... p53 and bcl-2 Expression in Invasive and Pre-invasive Uterine Papillary Serous Carcinoma and Atrophic Endometrium. I Busmanis, ... For both markers, the invasive phase of carcinoma, as well as normal and hyperplastic endometrium, have been examined, but the ... as well as normal endometrium to determine its biologic significance. The other major aim was to determine if these IHC results ...
Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial...
Maternal dietary protein deficiency decreases nitric oxide synthase and ornithine decarboxylase activities in placenta and...
At d 40 or 60 of gestation, they were hysterectomized, and placenta and endometrium were obtained for incubations, NOS and ODC ... At d 40 or 60 of gestation, they were hysterectomized, and placenta and endometrium were obtained for incubations, NOS and ODC ... At d 40 or 60 of gestation, they were hysterectomized, and placenta and endometrium were obtained for incubations, NOS and ODC ... At d 40 or 60 of gestation, they were hysterectomized, and placenta and endometrium were obtained for incubations, NOS and ODC ...
DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to...
The inner uterine lining (endometrium) is a unique tissue going through remarkable changes each menstrual cycle. Endometrium ... DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to ... DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to ... DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to ...
Vaskularisering, körtlar och leukocytförekomst i endometrium hos tik under metöstrus och tidig dräktighet - Epsilon Archive...
No difference could be seen in total number of blood vessels in the superficial and basal zones of the endometrium between the ... However the means in general showed a lower number of blood vessels in the endometrium during early pregnancy compared to early ... This study is concentrating on the presence of blood vessels, glands and leucocytes in different layers of the endometrium from ... By histological inspection of the endometrium, a difference between pregnancy day 8-9 compared with early and mid metoestrus ...
Role of progesterone in structural and biochemical remodeling of endometrium
... Gracy Rosario1. , Geetanjali Sachdeva1. , William ... Role of progesterone in structural and biochemical remodeling of endometrium. Front. Biosci. (Landmark Ed) 2003, 8(6), 924-935 ... We have attempted to investigate in vivo morphological and biochemical/molecular changes in endometrium in response to ... The results coincided with those observed in the endometrium of the other model, bonnet monkeys presenting normal hypothalamus- ...
The Activity of Mitochondrial Superoxide Dismutase in Normal and Pathological Endometrium and Correlation with the Hormonal...
Zinc induced changes in the progesterone binding properties of the human endometrium in: European Journal of Endocrinology...
Single cell type - HRAS - The Human Protein Atlas
Time-dependent mRNA expression of selected pro-inflammatory factors in the endometrium of primiparous cows postpartum |...
... was observed in samples from cows with an inflamed endometrium compared with samples from cows with a healthy endometrium (P & ... lt; 0.05). These results show that inflammatory cytokines and acute phase proteins are expressed in the bovine endometrium in a ... in samples from an inflamed endometrium than in samples from a healthy endometrium (mean of normalised expression ± S.E.M. × 10 ... CXCL5 mRNA expression was higher in samples obtained from an inflamed endometrium compared with the healthy endometrium (P , ...
Injectable and oral contraceptive use and cancers of the breast, cervix, ovary, and endometrium in black South African women:...
Mucinous adenocarcinoma of the endometrium with metastasis to the clitoral glans after pelvic exenteration for radiation...
Treatment of recurrent adenocarcinoma of the endometrium with pelvic exenteration. * Authors: Morris M, Alvarez RD, Kinney WK, ... Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a ... Mogor, O., Hargrave, E., Rush, D., & Hatch, K. (2019). Mucinous adenocarcinoma of the endometrium with metastasis to the ... Mucinous adenocarcinoma of the endometrium (MACE) is a rare subtype of endometrial adenocarcinoma that often presents a ...
endometrium | BOTANICALSLIMMINGSOFTGELSELL
Lectin-Binding Patterns in Normal Endometrium and Endometrial Adenocarcinoma<...
... demonstrated markedly enhanced binding in secretory endometrium compared with endometrium in the proliferative phase. Ulex ... demonstrated markedly enhanced binding in secretory endometrium compared with endometrium in the proliferative phase. Ulex ... demonstrated markedly enhanced binding in secretory endometrium compared with endometrium in the proliferative phase. Ulex ... demonstrated markedly enhanced binding in secretory endometrium compared with endometrium in the proliferative phase. Ulex ...
Thymidine phosphorylase expression in normal and hyperplastic endometrium. - Department of Oncology
Ninety two normal and hyperplastic endometria were studied. RESULTS: In normal proliferative endometrium, TP is found ... In normal endometrium, TP has a definite pattern of distribution, which is dependent on the phase of the menstrual cycle, ... In simple endometrial hyperplasia, the staining pattern for TP is identical to normal proliferative endometrium, with a ... CONCLUSIONS: TP is expressed consistently in normal and hyperplastic endometrium, suggesting a role in physiological and ...
Details for: Blastocyst-endometrium relationships / › WHO HQ Library catalog
IMSEAR at SEARO: HISTOCHEMICAL STUDIES IN HISTOLOGICALLY NORMAL ENDOMETRIUM.
Genes Regulated by Estrogen and Progesterone in Human Endometrium - TalTech raamatukogu digikogu
Administration of a herbal formulation enhanced blastocyst implantation via IκB activation in mouse endometrium | Chinese...
Endometria were stained with H&E (a). Uterus tissues were homogenized and immunoblotted with MT1-MMP and MMP2 antibodies (b). ... 5b, c). To confirm the effect of BCB treatment on endometrium development, H&E staining of uterus tissue was carried out. Mice ... However, how BCB regulates IκBα activation in endometrium remains unknown.. NF-κB is critical for the induction of both iNOS ... Administration of a herbal formulation enhanced blastocyst implantation via IκB activation in mouse endometrium. *Songhee Jeon1 ...