AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
EndometriosisEndometriumPelvic PainPeritoneal DiseasesOvarian DiseasesDysmenorrheaInfertility, FemaleAscitic FluidUterine DiseasesDanazolRectal DiseasesLaparoscopyDyspareuniaMenstrual CycleUreteral DiseasesSigmoid DiseasesPapio anubisVaginal DiseasesStromal CellsOvarian CystsPelvisMenstruationDigestive System DiseasesUrinary Bladder DiseasesMenstruation DisturbancesCase-Control StudiesChoristomaCA-125 AntigenLeuprolideGynecologic Surgical ProceduresPeritoneumThoracic DiseasesDouglas' PouchUmbilicusDiagnostic Techniques, Obstetrical and GynecologicalInfertilityAbdominal WallUterusPapioEncyclopedias as TopicInfertility, MaleCoagulation Protein DisordersMenopauseMenarcheEstrogensFertilityGynecologyObstetricsFallopian TubesFallopian Tube NeoplasmsVaginaRectum
Endometriosis: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.Endometrium: The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.Pelvic Pain: Pain in the pelvic region of genital and non-genital origin and of organic or psychogenic etiology. Frequent causes of pain are distension or contraction of hollow viscera, rapid stretching of the capsule of a solid organ, chemical irritation, tissue ischemia, and neuritis secondary to inflammatory, neoplastic, or fibrotic processes in adjacent organs. (Kase, Weingold & Gershenson: Principles and Practice of Clinical Gynecology, 2d ed, pp479-508)Peritoneal Diseases: Pathological processes involving the PERITONEUM.Ovarian Diseases: Pathological processes of the OVARY.Dysmenorrhea: Painful menstruation.Infertility, Female: Diminished or absent ability of a female to achieve conception.Ascitic Fluid: The serous fluid of ASCITES, the accumulation of fluids in the PERITONEAL CAVITY.Uterine Diseases: Pathological processes involving any part of the UTERUS.Danazol: A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.Rectal Diseases: Pathological developments in the RECTUM region of the large intestine (INTESTINE, LARGE).Laparoscopy: A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.Dyspareunia: Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.Menstrual Cycle: The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.Ureteral Diseases: Pathological processes involving the URETERS.Sigmoid Diseases: Pathological processes in the SIGMOID COLON region of the large intestine (INTESTINE, LARGE).Papio anubis: A species of baboon in the family CERCOPITHECIDAE with a somewhat different social structure than PAPIO HAMADRYAS. They inhabit several areas in Africa south of the Sahara.Vaginal Diseases: Pathological processes of the VAGINA.Stromal Cells: Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.Ovarian Cysts: General term for CYSTS and cystic diseases of the OVARY.Pelvis: The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.Menstruation: The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.Digestive System Diseases: Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).Urinary Bladder Diseases: Pathological processes of the URINARY BLADDER.Menstruation Disturbances: Variations of menstruation which may be indicative of disease.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Choristoma: A mass of histologically normal tissue present in an abnormal location.CA-125 Antigen: Carbohydrate antigen most commonly seen in tumors of the ovary and occasionally seen in breast, kidney, and gastrointestinal tract tumors and normal tissue. CA 125 is clearly tumor-associated but not tumor-specific.Leuprolide: A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE.Gynecologic Surgical Procedures: Surgery performed on the female genitalia.Peritoneum: A membrane of squamous EPITHELIAL CELLS, the mesothelial cells, covered by apical MICROVILLI that allow rapid absorption of fluid and particles in the PERITONEAL CAVITY. The peritoneum is divided into parietal and visceral components. The parietal peritoneum covers the inside of the ABDOMINAL WALL. The visceral peritoneum covers the intraperitoneal organs. The double-layered peritoneum forms the MESENTERY that suspends these organs from the abdominal wall.Thoracic Diseases: Disorders affecting the organs of the thorax.Douglas' Pouch: A sac or recess formed by a fold of the peritoneum.Umbilicus: The pit in the center of the ABDOMINAL WALL marking the point where the UMBILICAL CORD entered in the FETUS.Diagnostic Techniques, Obstetrical and Gynecological: Methods and procedures for the diagnosis of conditions related to pregnancy, labor, and the puerperium and of diseases of the female genitalia. It includes also demonstration of genital and pregnancy physiology.Infertility: Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility.Abdominal Wall: The outer margins of the ABDOMEN, extending from the osteocartilaginous thoracic cage to the PELVIS. Though its major part is muscular, the abdominal wall consists of at least seven layers: the SKIN, subcutaneous fat, deep FASCIA; ABDOMINAL MUSCLES, transversalis fascia, extraperitoneal fat, and the parietal PERITONEUM.Uterus: The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.Papio: A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.Coagulation Protein Disorders: Hemorrhagic and thrombotic disorders resulting from abnormalities or deficiencies of coagulation proteins.Menopause: The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.Menarche: The first MENSTRUAL CYCLE marked by the initiation of MENSTRUATION.Estrogens: Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.Fertility: The capacity to conceive or to induce conception. It may refer to either the male or female.Gynecology: A medical-surgical specialty concerned with the physiology and disorders primarily of the female genital tract, as well as female endocrinology and reproductive physiology.Obstetrics: A medical-surgical specialty concerned with management and care of women during pregnancy, parturition, and the puerperium.Fallopian Tubes: A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.Fallopian Tube Neoplasms: Benign or malignant neoplasms of the FALLOPIAN TUBES. They are uncommon. If they develop, they may be located in the wall or within the lumen as a growth attached to the wall by a stalk.Vagina: The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.

Molecular and cellular aspects of endometrial receptivity. (1/1690)

Endocrine and paracrine controls regulate the endometrium during the luteal phase of the cycle to permit implantation. Part of this differentiation process is the production of a specific secretion which fills the intrauterine cavity and glandular lumen. Its molecular composition originates from the gland secretion, from transudations from stroma, from the endometrial blood vessels, and last, but not least, from cellular components of apoptotic and exfoliated cells. We have studied the secretions of all phases during the menstrual cycle using patterns evaluated by SDS-PAGE, by laser densitometry or Western blots. Uterine secretion electrophoresis (USE) permits detailed analyses of the intrauterine micromilieu and allows clinical assessment of the receptive stage of endometrium during the luteal phase. Several individual protein bands have been defined as characteristic markers for such receptive pattern. We have isolated and identified the molecular structure of several of these proteins, e.g. histones, cyclophilin, transthyretin, haptoglobin and uteroglobin. Investigations on the endocrine regulation of these proteins, were carried out on the uterine secretions of patients treated with progesterone antagonists (mifepristone and onapristone). The results demonstrate how progesterone-dependent components produce a receptive pattern, which can serve as a useful and precise marker in the clinical diagnosis of the luteal phase. Essential progesterone-dependent components differentiating during the luteal phase may provide new targets for contraceptive interventions by preventing the physiological changes typical of receptivity.  (+info)

Decreased apoptosis and sensitivity to macrophage mediated cytolysis of endometrial cells in endometriosis. (2/1690)

Ectopic dissemination of endometrial cells and their subsequent implantation are the mechanisms involved in the development of endometriosis. While the process of dissemination appears to be a phenomenon common to all women, it is unknown what facilitates or prevents ectopic implantation of misplaced endometrial cells. Prior studies by our group and others suggest that cell-mediated immunity in patients with endometriosis is decreased. The present studies evaluated (i) peripheral blood monocyte (PBM) and peritoneal macrophage (PM) mediated cytolysis of autologous eutopic and ectopic endometrial cells and (ii) programmed cell death (apoptosis) in the eutopic and ectopic endometrium. PBM-mediated cytolysis was (mean+/-SD) 23.1+/-13% for the eutopic and 7.8+/-% for the ectopic endometrium (P < 0.004), while the corresponding percentages for PM-mediated cytolysis were 5.4+/-7 and 0.3+/-1 respectively (P < 0.04). This indicates that PBM are much more effective than PM in inducing cytolysis of both eutopic and ectopic endometrium and that ectopic endometrial cells are significantly more resistant to both PBM- and PM-mediated cytolysis. The apoptosis was significantly decreased in the eutopic endometrium of women with endometriosis as compared to fertile controls (0.375+/-0.17 versus 1.57+/-0.3, P < 0.0001). Furthermore, in matched samples apoptosis was significantly lower in the ectopic (0.149+/-0.075) than eutopic (0.375+/-0.17) endometrium (P < 0.001). We conclude from these studies that the decrease in the capacity of monocytes to mediate cytolysis of the misplaced endometrial cells in the peritoneal locations and an increased resistance of these cells to apoptosis are fundamental to the aetiology and/or pathophysiology of endometriosis.  (+info)

Phenotypic and functional studies of leukocytes in human endometrium and endometriosis. (3/1690)

The aetiology of endometriosis, a common and disabling disorder, is presently unknown, although immune dysfunction could allow ectopic endometrial fragments to survive outside the uterine cavity. These studies investigate the relationship between leukocyte populations, steroid hormone receptor expression, proliferative activity, bcl-2 expression and apoptosis in eutopic and ectopic endometrium from women with endometriosis or adenomyosis at different phases of the menstrual cycle. Significantly increased oestrogen receptor expression, bcl-2 expression and numbers of CD8+ leukocytes were found in ectopic compared with eutopic endometrium in endometriosis, and CD56+ endometrial granulated lymphocytes (eGLs) were significantly reduced in ectopic endometrium. Apoptotic cells were rarely found in control and subject endometria. In contrast with endometriosis, adenomyotic lesions showed identical steroid hormone receptor expression, proliferative activity, bcl-2 expression and leukocyte subpopulations to eutopic endometrium, indicating different aetiologies for these disorders. The unusual CD56+ CD16- eGLs present in large numbers in late secretory phase eutopic endometrium were highly purified (>98%) by immunomagnetic separation. Except for a negligible cytotoxic activity of eGLs from early proliferative samples, cytotoxic activity of eGLs from non-pregnant endometrium during the menstrual cycle was comparable with those in peripheral blood, predominantly CD56+ CD16+ natural killer cells. eGLs from non-pregnant endometrium and early pregnancy showed a variable proliferative response to 5 and 100 U/ml interleukin-2 over 48-h and 120-h time courses. eGLs are evidently functionally important in the eutopic endometrium. Their absence in endometriotic lesions together with increased CD+8 T-cell numbers and increased oestrogen receptor and bcl-2 expression may have significant effects on the development and progression of endometriosis.  (+info)

Expression pattern of integrin adhesion molecules in endometriosis and human endometrium. (4/1690)

Integrins are cell adhesion molecules that undergo cell-specific dynamic changes during the normal menstrual cycle in the human endometrium. Here, using immunohistochemistry, we have investigated the expression pattern of the integrins alphav, alpha2beta1, alpha3beta1, alpha3, alpha6, beta1, beta2 and beta3 in the human ectopic endometrium of 30 patients and in nine cases in the corresponding eutopic endometrium. The biopsies were obtained during the early or late follicular phase (25 cases), during the corpus luteum phase (four cases) and in one case after 6 months' treatment with a gonadotrophin releasing hormone (GnRH) agonist. The integrin expression was independent of the ovarian steroid situation at the time of biopsy. The integrin alpha6 was expressed in all endometriotic and endometrium samples. The integrin alpha3 was absent in all endometrium tissues of patients with endometriosis. However, the corresponding endometriotic lesions re-expressed this adhesion molecule in 15 cases. No change in integrin beta3 expression pattern could be demonstrated in either endometriotic lesions or endometrium samples, regardless of the menstrual cycle phase. A correlation between serum oestradiol and progesterone concentrations and the expression of the investigated integrins was not observed, thus indicating that these two hormones play a minor role in the regulation of the cell adhesion molecules examined. Our investigation suggests that endometriosis is a dedifferentiated disease as it expressed different integrins in comparison with the eutopic endometrium, and independently of the hormonal situation. The ability of endometriotic tissues to express integrins may explain the high recurrence rates in patients with endometriosis, as these samples retain their adhesion potency after retrograde menstruation and are thus able to establish cell-cell and cell-matrix interactions with the surrounding peritoneum.  (+info)

Paracrine changes in the peritoneal environment of women with endometriosis. (5/1690)

During the past decade, macrophage-derived substances such as prostanoids, cytokines, growth factors and angiogenic factors have been detected in the peritoneal fluid of women with endometriosis. In particular, growth-promoting and angiogenic factors are considered to be substantially involved in the pathogenesis of endometriosis. In this study, vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF-beta) and intercellular adhesion molecule 1 (ICAM-1), substances recently detected in the peritoneal fluid of women with endometriosis, were assessed with regard to their concentrations in different stages of endometriosis and changes of the peritoneal paracrine activity after medical treatment with a gonadotrophin releasing hormone agonist (GnRHa). Peritoneal fluid was obtained from patients with endometriosis during laparoscopy before and after a 4-month treatment with a GnRHa. VEGF, TGF-beta and ICAM-1 could be detected in all women presenting with various stages of active endometriosis. After GnRHa therapy, all patients showed significant decreases in mean concentrations of VEGF (194+/-77 pg/ml), TGF-beta (902+/-273 pg/ml) and ICAM-1 (157+/-52 ng/ml). Patients with stage III and IV endometriosis (according to the rAFS score) had much higher concentrations of VEGF and TGF-beta before treatment compared with those patients with mild endometriosis (rAFS stages I and II). The most striking decrease in concentration was for TGF-beta, from 902 pg/ml before to 273 pg/ml after therapy. These results indicate an important role for paracrine activity in the establishment and maintenance of endometriosis. Indeed, treatment with a GnRHa may reduce paracrine activity in the peritoneal cavity via hypo-oestrogenism and provide proof of successful therapy.  (+info)

Tracing cellular and molecular mechanisms involved in endometriosis. (6/1690)

The aetiology and pathogenesis of endometriosis, defined as the presence of endometrium-like tissue outside the uterine cavity, is largely unknown. In this paper we present and discuss possibilities to study the putative pathogenic properties of endometriotic cells in vitro. The current focus of our investigations is on the invasive phenotype of the disease, assuming that this might contribute to the pathogenesis of endometriosis. So far, we have shown that: (i) cytokeratin-positive and E-cadherin-negative endometriotic cells have an invasive phenotype in a collagen invasion assay in vitro similar to metastatic carcinoma cells; (ii) the invasiveness of endometriotic but not of eutopic endometrial cells can be stimulated by a heat-stable protein present in peritoneal fluid; and (iii) the endometriotic cell line EEC145T, which we established, may be a useful tool for the identification of gene products which are, positively or negatively, invasion-related. Finally, our studies suggest that the invasive phenotype in endometriosis shares aspects with tumour metastasis, but might also have unique mechanisms.  (+info)

Extracellular matrix remodelling in the endometrium and its possible relevance to the pathogenesis of endometriosis. (7/1690)

Essential features of endometrial physiology involve the extracellular matrix (ECM). In the pathogenesis of endometriosis, interactions of endometriosis cells with ECM can be postulated. Two systems of secreted proteases in the endometrium, the plasmin(ogen) activator/inhibitor and the matrix metalloproteinases and their inhibitors were examined in cell cultures of uterine endometrial cells from women with and without endometriosis. Soluble urokinase receptor secretion is increased, and mRNA transcription of tissue inhibitor of metalloproteinases-2 (TIMP-2) is upregulated by progestin in endometriosis. These findings are compatible with an altered ECM turnover in the endometrium of these patients that may explain a higher invasive potential of retrogradely menstruated endometrial fragments.  (+info)

Angiogenesis: a new theory for endometriosis. (8/1690)

Excessive endometrial angiogenesis is proposed as an important mechanism in the pathogenesis of endometriosis. Evidence is reviewed for the hypothesis that the endometrium of women with endometriosis has an increased capacity to proliferate, implant and grow in the peritoneal cavity. Data is summarized indicating that the endometrium of patients with endometriosis shows enhanced endothelial cell proliferation. Results are also reviewed indicating that the cell adhesion molecule integrin alphavbeta3 is expressed in more blood vessels in the endometrium of women with endometriosis when compared with normal women. Taken together, these results provide evidence for increased endometrial angiogenesis in women with endometriosis when compared with normal subjects. Endometriosis is one of the family of angiogenic diseases. Other angiogenic diseases include solid tumours, rheumatoid arthritis, psoriasis and diabetic retanopathy. Excessive endometrial angiogenesis suggests novel new medical treatments for endometriosis aimed at the inhibition of angiogenesis.  (+info)

Suturing versus flowering technique of Bruhat after fimbrioplasty for endometriosis-related infertility<...Suturing versus flowering technique of Bruhat after fimbrioplasty for endometriosis-related infertility<...
TY - JOUR. T1 - Suturing versus flowering technique of Bruhat after fimbrioplasty for endometriosis-related infertility. AU - Mitwally, Mohamed F.. AU - Thotakura, Anusha. AU - Abuzeid, Omar. AU - Ashraf, Mohammad. AU - Diamond, Michael P.. AU - Abuzeid, Mostafa. N1 - Copyright: Copyright 2009 Elsevier B.V., All rights reserved.. PY - 2009/5. Y1 - 2009/5. N2 - The objective of this study is to compare the effectiveness of two surgical techniques (suturing versus flowering of Bruhat) after fimbrioplasty for treatment of distal tubal pathology in infertile women with endometriosis. This is a historical cohort study with 12 months of follow-up comparing pregnancy rates achieved spontaneously or after controlled ovarian hyperstimulation (COS) with intrauterine insemination (IUI) in infertile women with endometriosis who underwent laparoscopic fimbrioplasty. A total of 154 patients with endometriosis-related infertility (pelvic inflammatory disease was excluded by absent history and negative ...
Home Remedies for Endometriosis - The HealthologyHome Remedies for Endometriosis - The Healthology
Other than retrograde menstruation, experts say that endometriosis may also be brought about by a few other factors. Some of them include a weakened immune system, environmental toxins and genetics.. Women with endometriosis may experience a host of unfavorable symptoms. It all depends on the conditions current stage, which is determined by the likes of location, depth, size and number. Some women with endometriosis may have mild symptoms only, while others have moderate to severe symptoms. Its important to note that the severity of the symptoms has nothing to do with the stage of endometriosis. For instance, a woman may have mild endometriosis only but may experience a great deal of pain.. Aside from pain in the lower abdomen before and during menstruation, others symptoms of endometriosis include pain after sexual intercourse, discomfort during bowel movements and heavy menstrual bleeding. A woman with endometriosis may also notice some blood in between periods. Sometimes, the condition may ...
Bowel endometriosis - Endo HealthBowel endometriosis - Endo Health
Bowel endometriosis is invariably associated with other significant endometriosis (eg endometrioma/chocolate cysts, or adenomyosis). Bowel endometriosis tends to slowly and progressively worsen in women who are pre-menopausal. It is rare for the bowel to be obstructed by endometriosis.. When the bowel is involved, there is generally a range of symptoms that a patient may experience; in particular, a cyclic change in bowel habit (diarrhoea, constipation or both) or cyclic bowel pain, always worst when the period is due. Women with bowel-related endometriosis will almost invariably have reduced fertility. Sometimes it is necessary to correct the pelvic and bowel endometriosis before a woman can conceive naturally. It is usual for patients with documented bowel endometriosis to experience back pain, sex pain and ovulation pain.. Investigating bowel pain by pelvic ultrasound scan or MRI scan is always a good starting point. The scan must be very specific, by an ultrasonologist or radiologist trained ...
Endometriosis - technical article | eNetMDEndometriosis - technical article | eNetMD
1. Simoens S, Dunselman G, Dirksen C, Hummelshoj L, Bokor A, Brandes I, et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27(5):1292-9.. 2. Koninckx PR, Mueleman C, Demeyere S, Lesaffre E, Cornillie FJ. Suggestive evidence that pelvic endometriosis is a progressive disease, whereas deeply infiltrating endometriosis is associated with pelvic pain. Fertil Steril. 1991;55(4):759-65.. 3. Harirchian P, Gashaw I, Lipskind ST, Braundmeier AG, Hastings JM, Olson MR, et al. Lesion kinetics in a non-human primate model of endometriosis. Hum Reprod. 2012;27(8):2341-51.. 4. Falcone T, Lebovic DI. Clinical management of endometriosis. Obstet Gynecol. 2011;118(3):691-705.. 5. Fassbender A, Waelkens E, Verbeeck N, Kyama CM, Bokor A, Vodolazkaia A, et al. Proteomics analysis of plasma for early diagnosis of endometriosis. Obstet Gynecol. 2012;119(2 Pt 1): 276-85.. 6. Revised American Fertility Society classification of ...
Ureter Endometriosis | MedCraveUreter Endometriosis | MedCrave
Ureter endometriosis is a rare clinical condition with up to 12% of women with endometriosis affected in the urinary tract [1,2]. The proportion of involvement of bladder, ureter and kidney is said to be 40:5:1 [3,4]. Of special concern ureteral endometriosis is a silent disease with most patients without specific symptoms (related to the ureter) and, more commonly with pelvic pain (dysmenorrhea and dyspareunia) that affects most patients with endometriosis. In patients without pain symptoms the diagnosis of endometriosis can be delayed leading to silent loss of kidney function [5,6]. Ureteral endometriosis can be intrinsic or extrinsic to the ureteral wall [7,8]. Extrinsic type is considered the most common [9].. Surgical treatment is feasible and safe [10,11]. Ureter endometriosis can be treated either by ureterolysis, segmental ureterectomy with end-to-end anastomosis or ureteroneocystostomy. The surgical strategy published by Wattiez et al. [12] starts with retroperitoneal inspection of ...
Living with endometriosis information session (2014) - Womens Centre for Health Matters, CanberraLiving with endometriosis information session (2014) - Women's Centre for Health Matters, Canberra
WCHM supported the Canberra Endometriosis Network by hosting an information night exploring the impacts of living with the illness endometriosis on Tuesday 26 August 2014. Attendees heard from endometriosis researcher Maryam Moradi, Dr Omar Adham and Melissa Parker from the Canberra Endometriosis Centre, and Katie Williams, member of the Canberra Endometriosis Network. These speakers addressed the questions: What are the personal impacts of living with endometriosis? How does endometriosis impact upon womens relationships with lovers, family, friends and work colleagues? How does societys attitudes toward and understanding about endometriosis impact the women living with this condition? More than 100 women, partners, family members and friends attended the event.. The event was also an opportunity for local artist Margaret Kalms to launch her photographic project Life with Endometriosis.. ...
Risk of miscarriage in women with endometriosis undergoing IVF fresh cycles: a retrospective cohort study | Reproductive...Risk of miscarriage in women with endometriosis undergoing IVF fresh cycles: a retrospective cohort study | Reproductive...
Endometriosis is thought to affect the effectiveness of ART by an increased risk of miscarriage. We aimed to investigate the impact of endometriosis in women achieving singleton pregnancies through IVF fresh cycles and risk of miscarriage. This retrospective cohort study included all women undergoing a first IVF cycle and achieving singleton pregnancies after fresh embryo transfer in a tertiary university hospital reproductive medical center between January 2008 and June 2016. Women with endometriosis were compared with women with no endometriosis. Women in the endometriosis group were all with a history of laparoscopy or laparotomy for endometriosis and/or with ovarian endometrioma. The control group was matched 1:2 according to age and study period. Among the cohort, we identified 1006 women with endometriosis as study group and 2012 unaffected women matched in a 1:2 ratios as control group. The miscarriage rate between women with and without endometriosis was similar (22.4 and 20.1%, P = 0.085). The
Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis<...Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis<...
TY - JOUR. T1 - Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis. AU - Reis, Fernando M.. AU - Di Blasio, Anna M.. AU - Florio, Pasquale. AU - Ambrosini, Guido. AU - Di Loreto, Carla. AU - Petraglia, Felice. PY - 2001. Y1 - 2001. N2 - Objective: To evaluate the expression of inhibin A and activin A in ovarian endometriosis. Design: Uncontrolled cross-sectional study and controlled prospective in vitro study. Setting: Academic health centers in Siena, Udine, Sassari, and Milan, Italy. Patient(s): A group of women (n = 19) who underwent laparoscopic excision of ovarian endometriotic cysts. Intervention(s): Specimens of serum, peritoneal fluid, and cystic fluid, ovarian tissue for immunohistochemistry, and endometriotic cells for primary culture were collected. Cell cultures were also prepared from proliferative endometrium of women without endometriosis. Main Outcome Measures(s): Dimeric inhibin A and activin A concentrations in biological fluids; ...
PRIME PubMed | Leptin concentrations in the peritoneal fluid of women with ovarian endometriosis are different according to the...PRIME PubMed | Leptin concentrations in the peritoneal fluid of women with ovarian endometriosis are different according to the...
PubMed journal article Leptin concentrations in the peritoneal fluid of women with ovarian endometriosis are different according to the presence of a deep or superficial ovarian diseas were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Luminescence as a Tool to Assess Pelvic Endometriosis Development in Murine Models. | DIAL.pr - BOREALLuminescence as a Tool to Assess Pelvic Endometriosis Development in Murine Models. | DIAL.pr - BOREAL
Classic murine endometriosis models may be insufficient to evaluate the effect of therapeutic agents on endometriosis development, because the process of identification and measurement of induced lesions is often impeded, as implants are small and embedded in murine tissue. In this context, as summarized in the current review, luminescence techniques have proved useful for identifying and visualizing or quantifying endometriotic transplants. They are also a valuable tool for endometrial cell tracking in live animals, yielding further information by adding spatial and temporal dimensions to biological processes in vivo. Such approaches involve transplanting luminescently labeled murine or human endometrium into animals. Two main strategies are applied to label endometrium before injection: use of genetically modified tissue or tissue labeled with a fluorescent dye. Each model has its advantages and disadvantages, the choice of model depends on the study objectives/design (long- or short-term ...
Genetic burden associated with varying degrees of disease severity in endometriosis. - Nuffield Department of MedicineGenetic burden associated with varying degrees of disease severity in endometriosis. - Nuffield Department of Medicine
Endometriosis is primarily characterized by the presence of tissue resembling endometrium outside the uterine cavity and is usually diagnosed by laparoscopy. The most commonly used classification of disease, the revised American Fertility Society (rAFS) system to grade endometriosis into different stages based on disease severity (I to IV), has been questioned as it does not correlate well with underlying symptoms, posing issues in diagnosis and choice of treatment. Using two independent European genome-wide association (GWA) datasets and top-level classification of the endometriosis cases based on rAFS [minimal or mild (Stage A) and moderate-to-severe (Stage B) disease], we previously showed that Stage B endometriosis has greater contribution of common genetic variation to its aetiology than Stage A disease. Herein, we extend our previous analysis to four endometriosis stages [minimal (Stage I), mild (Stage II), moderate (Stage III) and severe (Stage IV) disease] based on the rAFS classification system
Minimally Invasive Surgery for Endometriosis | Frontiers Research TopicMinimally Invasive Surgery for Endometriosis | Frontiers Research Topic
Endometriosis is defined as the presence of endometrial-like endometrial cells, glands and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. The exact prevalence of endometriosis is unknown, but the estimates range from 2-10 % of women of reproductive age, to 50 % of infertile women. Its etiopathogenesis of endometriosis still remains controversial: immune, hormonal, genetic, and epigenetic factors may be all involved, and several theories have been proposed to explain it.Endometriosis can cause several symptoms and signs, including acute and chronic pelvic pain, dysmenorrhea, dyspareunia, abnormal vaginal bleeding, infertility/sterility and, in the severe stage, gastrointestinal and urological symptoms. Three main clinical presentations have been described: peritoneal endometriosis, endometriotic ovarian cysts (i.e., endometriomas), and deeply infiltrating endometriosis (DIE) .The latter is considered the most aggressive presentation of endometriosis
Elevated serum levels of endometrial secretory protein PP14 in patients with advanced endometriosis. Pelvic endometriosis...Elevated serum levels of endometrial secretory protein PP14 in patients with advanced endometriosis. Pelvic endometriosis...
Elevated serum levels of endometrial secretory protein PP14 in patients with advanced endometriosis. Pelvic endometriosis mimicking advanced ovarian cancer: presentation with pleural effusion, ascites, and elevated serum CA 125 level
Treatment of Endometriosis-Associated Pain | Best Fertility Clinic Los Angeles | Infertility Clinic | LA IVF ClinicTreatment of Endometriosis-Associated Pain | Best Fertility Clinic Los Angeles | Infertility Clinic | LA IVF Clinic
Additional medical treatment strategies that are currently approved include medications classified as GnRH agonists, high dose progestins, androgens, and aromatase inhibitors.. GnRH agonists are one of the most effective treatments for endometriosis-associated pain. Endometriosis lesions grow when serum estradiol concentrations are in the premenopausal range (30 to 300 pg/mL) and regress when estradiol levels are in the menopausal range (,20 pg/mL). These medications act centrally, inhibiting the brains signals to the ovaries to make estrogen, decreasing the circulating estrogen concentration to menopausal levels and shutting down growth of endometriosis. Numerous clinical trials have demonstrated that approximately 85% of women with endometriosis and pelvic pain who are treated with GnRH agonist analogues experience relief of their pain, but not without side effects. The most common side effects are related to menopausal symptoms such as vasomotor symptoms (hot flashes), decreased libido, ...
Extrapelvic endometriosis: a rare entity or an under diagnosed condition? | Diagnostic Pathology | Full TextExtrapelvic endometriosis: a rare entity or an under diagnosed condition? | Diagnostic Pathology | Full Text
Endometriosis is a clinical entity characterized by the presence of normal endometrial mucosa abnormally implanted in locations other than the uterine cavity. Endometriosis can be either endopelvic or extrapelvicdepending on the location of endometrial tissue implantation. Despite the rarity of extrapelvic endometriosis, several cases of endometriosis of the gastrointestinal tract, the urinarytract, the upper and lower respiratory system, the diaphragm, the pleura and the pericardium, as well as abdominal scars loci have been reported in the literature. There are several theories about the pathogenesis and the pathophysiology of endometriosis. Depending on the place of endometrial tissue implantation, endometriosis can be expressed with a wide variety of symptoms. The diagnosis of this entity is neither easy nor routine. Many diagnostic methods clinical and laboratory have been used, but none of them is the golden standard. The multipotent localization of endometriosis in combination with the wide range
Molecular and biological genetic inductors of change mucous endometrium at external genital endometriosis - medexpertMolecular and biological genetic inductors of change mucous endometrium at external genital endometriosis - medexpert
Center for Family Planning and Human Reproduction, Krivoy Rog The main theories of the pathogenesis of endometriosis are described. A modern approach is presented concerning the eutopic endometrium of patients with endometriosis and endometrioid heterotopia, including changes in the expression of inducers of adhesion, invasion, angiogenesis, hormonal inducers, receptivity and inducers of immunity. Differences in healthy endometrium, endometrium of patients with endometriosis and endometrioid heterotopia have been determined. These studies contribute to increasing knowledge of the pathogenesis of endometriosis, the timely identification of possible therapeutic targets and, in addition, realize the effectiveness of methods for early diagnosis and prediction of the course of this pathology. Key words: endometriosis, ectopic endometrium, hormonal inducers, eutopic endometrium, receptivity. REFERENCES 1. Margarit L, Taylor A, Roberts MH, Hopkins L, Davies C, Brenton AG et al. 2010. MUC1 as a ...
Serum and Peritoneal Fluid Cytokine Profiles in Infertile Women with EndometriosisSerum and Peritoneal Fluid Cytokine Profiles in Infertile Women with Endometriosis
Background: Endometriosis is a chronic inflammatory disease with the growth of endometrial cells out of uterus and in the peritoneal cavity. T cell subsets participate in the establishment and progress of the disease by producing different cytokines. Objective: To investigate a group of cytokines related to Th1/Th2/Th17/Treg subsets within both peripheral blood and peritoneal fluid (PF) samples from infertile endometriosis women. Methods: Peripheral blood and PF samples were collected from 30 infertile endometriosis and 30 non-endometriosis fertile women during laparoscopy. Concentration of cytokines, including TNF-α, IFN-γ, TGF-β1, IL-4, IL-10, IL-17 and IL- 23 were evaluated using ELISA method. Results: Results indicated that the concentration of IFN-γ within serum was significantly reduced in endometriosis group (p=0.001). Regarding PF cytokines, TGF-β1 was increased in endometriosis group (p=0.030). Furthermore, the ratios of IFN-γ/TGF-β1 and IL-17/IL-23 were significantly different between
Endometriosis Diagnosis and PrognosisEndometriosis Diagnosis and Prognosis
... - Get information about diagnosis and prognosis of Endometriosis, onlymyhealth.com is providing articles related to Endometriosis diagnosis and prognosis.
Endometriosis and pregnancy outcomes - Princeton IVFEndometriosis and pregnancy outcomes - Princeton IVF
A new study from Scotland suggests that it may. It has been known for years that endometriosis can cause infertility, but it was less clear was whether it might affect the outcomes of those who do successfully conceive.. For those who are unfamiliar, endometriosis is a condition in which tissue resembling the endometrium (the lining of the uterus) grows in places where it does not normally belong such as as on the ovary, near the fallopian tubes or in other parts in the peritoneal membrane that lines the pelvis. Besides affecting fertility, endometriosis can result in painful menses (dysmenorrhea) and painful intercourse (dyspareunia). The symptoms of endometriosis are often cyclic, fluctuating along with a womans reproductive hormones.. In a large study presented at the ESHRE meeting in Lisbon, the group from Edinburgh in the UK, reported that women who with known endometriosis were more likely to have miscarriages and ectopic pregnancies that those who did not. While this does not prove that ...
New: Endometriosis is the number one cause of adhesions : Laparoscopy of AdhesiolysisNew: Endometriosis is the number one cause of adhesions : Laparoscopy of Adhesiolysis
Endometriosis is the number one cause for formation of adhesions in women of reproductive age. If we add the surgeries for endometriosis to the causes of adhesions one can refer to endometriosis as the most important factor contributing to adhesion formation and Adhesion Related Disorder in women.. A simple explanation: Endometriosis spots in the peritoneal cavity produce blood and inflammation thus result in adhesion formation. Adhesions and endometriotic inflammation adhere organs to each other, like uterus with ovaries and tubes. Surgical procedures for endometriosis remain high-risk procedures that produce adhesions again and again. Most of these surgeries are performed without any adhesion barriers so the reformation of adhesions is most relevant and contributing factor to pelvic pain, infertility and bowel symptoms.Severe adhesions in high stages of endometriosis finally forms the "frozen pelvis" we all know in women with endometriosis and recurrent surgeries. Both, endometriosis and ...
History of breast feeding and risk of incident endometriosis: Prospective cohort study<...History of breast feeding and risk of incident endometriosis: Prospective cohort study<...
TY - JOUR. T1 - History of breast feeding and risk of incident endometriosis. T2 - Prospective cohort study. AU - Farland, Leslie V.. AU - Eliassen, A. Heather. AU - Tamimi, Rulla M.. AU - Spiegelman, Donna. AU - Michels, Karin B.. AU - Missmer, Stacey A.. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Objective To investigate the association between lifetime breast feeding, exclusive breast feeding, postpartum amenorrhea, and incidence of endometriosis among parous women. Design Prospective cohort study. Setting Nurses Health Study II, 1989-2011. Participants 72 394women who reported having one or more pregnancies that lasted at least six months, 3296 of whom had laparoscopically confirmed endometriosis. For each pregnancy, women reported duration of total breast feeding, exclusive breast feeding, and postpartum amenorrhea. Main outcome measures Incident self reported laparoscopically confirmed endometriosis (96% concordance with medical record) in parous women. Multivariable Cox proportional hazard ...
Assessment of Performance of [18F]-FES for Endometriosis Diagnosis - Full Text View - ClinicalTrials.govAssessment of Performance of [18F]-FES for Endometriosis Diagnosis - Full Text View - ClinicalTrials.gov
Endometriosis is a benign chronic disease responsible for infertility and pelvic pain. One of the main problem of endometriosis is the significant delay of diagnosis.This delay has significant consequences for patients. Currently the definitive diagnosis of endometriosis and the evaluation of its lesional extension require performing laparoscopy and a histological analysis of biopsy and pathologic areas. Lesions of endometriosis whose development and growth are estrogen-dependent, express estrogen receptor (ER). [18F]FES (16α-[18F]Fluoro-17β-estradiol) is an analog of estrogen, used in positron emission tomography (PET), and a specific tracer of ER. We propose to evaluate the performance of this functional imaging as a diagnostic tool for endometriosis.. The aim of this multicenter, prospective, open study is to assess sensitivity of PET with [18F] -FES for diagnosing endometriosis compared to the gold standard (histological confirmation on biopsy or excision of lesions performed during ...
Anxiety, coping skills and hypothalamus-pituitary-adrenal (HPA) axis in patients with endometriosis.Anxiety, coping skills and hypothalamus-pituitary-adrenal (HPA) axis in patients with endometriosis.
BACKGROUND: Endometriosis is an inflammatory disease that is defined by growth of endometrial tissue outside the uterus, resulting in pain, infertility, and emotional distress. Previous studies have shown that the HPA axis is compromised in patients with chronic, painful diseases, including endometriosis. However, the underlying mechanisms and the physiological and emotional consequences of dysfunctions in the HPA axis in these patients are largely unknown. We aimed to understand whether diurnal circulating cortisol levels in women with endometriosis are affected and how this impacts their emotional and behavioral responses. METHODS: Thirty-two patients with endometriosis and 36 healthy control women provided saliva samples and completed a series of psychological questionnaires. Salivary cortisol levels were measured in duplicate using a colorimetric immunoassay. RESULTS: There were significant differences in average cortisol levels between endometriosis patients and controls. A negative correlation was
Peritoneal stromal endometriosis: a detailed morphological analysis of a large series of cases of a common and under-recognised...Peritoneal stromal endometriosis: a detailed morphological analysis of a large series of cases of a common and under-recognised...
Aims: It is generally considered that an unequivocal histological diagnosis of endometriosis requires the presence of endometrioid-type glands and endometrioid-type stroma. However, small nodules or plaques of endometrioid-type stroma without glands have been noticed by the authors in repeated peritoneal biopsies performed for suspected endometriosis. These are often, but not always, accompanied by typical endometriosis with glands. This form of endometriosis has been previously referred to as stromal or micronodular stromal endometriosis. However, there has been little reference to this condition in the literature.. Methods: In this study, there was a review of a large series (n = 274) of peritoneal biopsies with a diagnosis of endometriosis with a view to ascertaining the frequency of stromal endometriosis.. Results: Stromal endometriosis, characterised histologically by small microscopic nodules or plaques of endometrioid-type stroma, sometimes with a whorled pattern and prominent vascularity ...
Endometriosis and infertility - WikipediaEndometriosis and infertility - Wikipedia
In-vitro fertilization (IVF) procedures are effective in improving fertility in many women with endometriosis. IVF makes it possible to combine sperm and eggs in a laboratory and then place the resulting embryos into the womans uterus. The decision when to apply IVF in endometriosis-associated infertility cases takes into account the age of the patient, the severity of the endometriosis, the presence of other infertility factors, and the results and duration of past treatments. In ovarian hyperstimulation as part of IVF in women with endometriosis, using a standard GnRH agonist protocol has been found to be equally effective in regard to using a GnRH antagonist protocol in terms of pregnancy rate.[7][needs update] On the other hand, when using a GnRH agonist protocol, long-term (three to six months) pituitary down-regulation before IVF for women with endometriosis has been estimated to increase the odds of clinical pregnancy by fourfold.[7] No difference has been found between surgery ...
Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis - Full Text View - ClinicalTrials...Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis - Full Text View - ClinicalTrials...
Randomized double blinded placebo-controlled trial to evaluate: (1) the impact of letrozole use during ovarian hyperstimulation with respect to endometriosis-related symptoms, embryo/egg quality and quantity, and pregnancy rates, (2) the impact of ovarian hyperstimulation on endometriosis-related symptoms.. There will be a total of 60 participants, 20 participants with endometriosis randomized to the placebo group, 20 participants with endometriosis randomized to the letrozole group and 20 control patients with no history of endometriosis. Letrozole and placebo medication will be started on the first day of gonadotropin injections and continued until the day of trigger shot. Medication will be restarted the night of egg retrieval and continued for 2 weeks post retrieval. Endometriosis associated symptoms will be evaluated using a survey modeled after the clinical survey developed by the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project. Surveys ...
Understanding of endometriosis through ayurveda | International Journal of Current ResearchUnderstanding of endometriosis through ayurveda | International Journal of Current Research
Introduction: Endometriosis is one of the most common benign gynecological diseases characterized by the implantation and growth of viable endometrial tissue outside the uterine cavity. The exact prevalence of endometriosis is not known but estimates range from 10-15% within the women of reproductive age group. Women with endometriosis are usually confronted with one or both of the two major problems-Endometriosis associated pain and infertility. Pain includes dysmenorrhea, Dyspareunia, Dyschezia and non menstrual pelvic pain with a significant effect on various aspects of womens life including their social and sexual relationships, work and study. Objectives: The present work is an attempt to understand endometriosis through Ayurvedic concepts. Material and Methods: Ayurveda classics, text books of gynecology, and internet publications were consulted and reviewed for carrying out the present work. Conclusion: Endometriosis cannot be correlated to any single disease of Ayurveda. It can be ...
Jeffrey Dach MD Fenofibrate for Endometriosis, Part Two - Jeffrey Dach MDJeffrey Dach MD Fenofibrate for Endometriosis, Part Two - Jeffrey Dach MD
https://academic.oup.com/humupd/article/18/6/682/627018. Laschke, M. W., and M. D. Menger. "Anti-angiogenic treatment strategies for the therapy of endometriosis." Human reproduction update 18.6 (2012): 682-702.. initiation of the disease by retrograde menstruation of highly angiogenic endometrial fragments into the peritoneal cavity. Based on these findings, endometriosis has been classified as a typical angiogenic disease, such as cancer, psoriasis or diabetic retinopathy (Healy et al., 1998).. Several studies report that COX-2 is also crucially involved in the pathogenesis of endometriosis. COX-2 over-expression is found in both endometriotic lesions and eutopic endometrium of patients with endometriosis when compared with controls. treatment with COX-2 inhibitors prevents the implantation of endometrium to ectopic sites and induces the regression of established endometriotic lesions. Dopamine agonists. A decade ago, Basu et al. (2001) made the interesting discovery that the neurotransmitter ...
Womens Care Consultants - EndometriosisWomens Care Consultants - Endometriosis
The main symptom of endometriosis is pelvic pain. Pain may occur with sex, during bowel movements or urination, or just before or during your menstrual cycle. Menstrual bleeding may occur more than once a month. Endometriosis also may cause infertility.. No one is certain of the cause of endometriosis. For most women, a small amount of blood flows through the fallopian tubes into the abdomen during their periods. For women with endometriosis, the blood that flows through the tubes attach to other places and grow. Endometrial cells also may be carried through blood and lymph vessels.. The amount of pain does not tell you how severe your condition is. Some women with slight pain may have a severe case. Others who have a lot of pain may have a mild case.. Many women with endometriosis have no symptoms. In fact, they may first find out they have endometriosis if they are not able to get pregnant. Endometriosis is found in about one third of infertile women.. Women often find that symptoms are ...
IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors |...IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors |...
Endometriosis is a chronic, inflammatory disease characterized by the growth of endometrial tissue in aberrant locations outside the uterus. Neoangiogenesis or establishment of new blood supply is one of the fundamental requirements of endometriotic lesion survival in the peritoneal cavity. IL-17A is emerging as a potent angiogenic and proinflammatory cytokine involved in the pathophysiology of several chronic inflammatory diseases such as rheumatoid arthritis and psoriasis. However, sparse information is available in the context of endometriosis. In this study, we demonstrate the potential importance of IL-17A in the pathogenesis and pathophysiology of endometriosis. The data show a differential expression of IL-17A in human ectopic endometriotic lesions and matched eutopic endometrium from women with endometriosis. Importantly, surgical removal of lesions resulted in significantly reduced plasma IL-17A concentrations. Immunohistochemistry revealed localization of IL-17A primarily in the stroma ...
Endometriosis Articles, Studies, and Musings: Musings on mullerianEndometriosis Articles, Studies, and Musings: Musings on mullerian
This is purely my conjecture based on my readings. The literature refers to peritoneal endometriosis, ovarian endometriosis, and deep infiltrating endometriosis. Current theory points to defects when our pelvic organs are developed (Mullerianosis) that leave stem cells in the wrong place. This might also explain why other mullerian disorders such as adenomyosis are frequently seen in endometriosis patients as well. These stem cells are acted upon by hormones (puberty) to develop as glands and stroma and begin the process of making nerves and blood vessels to support itself - as any good stem cell should. However that tissue should not be in those wrong sites and an inflammatory response happens. Factors from the environment (food, physical activity, stress, etc) play a role in presentation of illness. This is why diet etc might affect symptoms but will not rid the person of the lesions. The different locations of stem cells left behind might influence how they are acted upon by hormones and ...
Association of miR-143 rs41291957 and rs4705342 genetic variants with endometriosis risk in infertile women - KAUMS Journal (...Association of miR-143 rs41291957 and rs4705342 genetic variants with endometriosis risk in infertile women - KAUMS Journal (...
Background: Infertility is one of the major human problems. One of the most important causes of infertility is endometriosis. Endometriosis, defined as the growth of endometrial tissue outside the uterine cavity, is a common gynecological disorder. Recent research has shown that miRNAs and their target mRNAs are differentially expressed in endometriosis. ...
Endometriosis | Healing Centers | Healing Centers | Healthways, Inc.Endometriosis | Healing Centers | Healing Centers | Healthways, Inc.
Although theories abound, just why some women develop endometriosis and others dont remains a mystery. Or why endometriosis produces painful or heavy periods in some and no symptoms in others. Or why some women with endometriosis are infertile and others are not. What doctors do agree on is what endometriosis is. Pieces of the lining of the uterus called the endometrium find their way outside the uterus and into the pelvis, where they implant themselves and grow. For a mild case of endometriosis, either...
Age-Related Differences in Quality of Life in Swedish Women with EndometriosisAge-Related Differences in Quality of Life in Swedish Women with Endometriosis
Objective: The purpose of this observational study was to evaluate the impact of endometriosis on quality of life (QoL) in different age groups of Swedish women with endometriosis. Recruitment occurred through the Endometriosis Association (Sweden) (n = 400) and five gynecology departments of five Swedish hospitals (n = 400). All voluntary female members of the patient organization and patients attending specialist clinics due to endometriosis (n = 800) were invited by sending them a questionnaire. An age-and gender-matched sample of the general Swedish population was used as a control group when analyzing SF-36 data. Methods: A postal questionnaire (including SF-36) was distributed to 800 women. The questionnaire was evaluated by using descriptive statistics, and SF-36 was evaluated according to standard methods. Results: Of the 449 (56%) self-administered questionnaires returned, 431 (96%) contained evaluable answers. Women with endometriosis have significantly lower SF-36 scores than the ...
Endometriosis-associated recto-sigmoid cancer: a case report | BMC Cancer | Full TextEndometriosis-associated recto-sigmoid cancer: a case report | BMC Cancer | Full Text
Endometriosis is a relatively common condition in women of reproductive age. Malignant transformation of intestinal endometriosis is a very rare event. We report a case in which a patient with a history of endometriosis underwent surgery for malignant intestinal endometriosis. A 55-year-old woman complained of rectorrhagia and intermittent abdominal pain. A neoplasm was revealed by colonoscopy, CT scan and F18-FDG PET/CT of the recto-sigmoidal colon. The patient underwent a rectal anterior resection, hysterectomy and bilateral salpingo-oophorectomy for treatment. According to the histological and immunohistochemical presentation, the diagnosis of endometriosis-associated recto-sigmoid cancer was confirmed. The patient was treated with adjuvant chemotherapy for 6 months. During the follow-up appointment 22 months later, there was clinical and radiographic evidence of recurrence in the rectum. The patient received chemotherapy again and will receive another surgery after two more cycles of chemotherapy.
Endometriosis: An Overview - HerHealthMatters | HerHealthMattersEndometriosis: An Overview - HerHealthMatters | HerHealthMatters
Endometriosis: An Overview of Symptoms and Treatments. Endometriosis is a sometimes painful condition that affects anywhere from 3% to 18% of the female population that has reached reproductive age. The reason for the variance in percentage is that while some women experience debilitating pain, others have no discomfort at all. Pelvic pain, lower back pain, leg pain, painful periods, painful bowel movements, and pain during intercourse are the most common symptoms associated with endometriosis.. The definition of endometriosis is the growth of endometrial cells outside of the uterus. These cells are normally shed during menstruation. But when a woman has endometriosis, these cells can attach themselves to the pelvic lining, fallopian tubes, ovaries, outer surface of the uterus, intestines, bladder, cervix, and/or vagina.. The cause of endometriosis is unknown, although family history can play a role. Retrograde menstruation, or backflow after ovulation into the pelvic region, is also believed to ...
Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication...Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication...
BACKGROUND: Endometriosis is a heritable common gynaecological condition influenced by multiple genetic and environmental factors. Genome-wide association studies (GWASs) have proved successful in identifying common genetic variants of moderate effects for various complex diseases. To date, eight GWAS and replication studies from multiple populations have been published on endometriosis. In this review, we investigate the consistency and heterogeneity of the results across all the studies and their implications for an improved understanding of the aetiology of the condition. METHODS: Meta-analyses were conducted on four GWASs and four replication studies including a total of 11 506 cases and 32 678 controls, and on the subset of studies that investigated associations for revised American Fertility Society (rAFS) Stage III/IV including 2859 cases. The datasets included 9039 cases and 27 343 controls of European (Australia, Belgium, Italy, UK, USA) and 2467 cases and 5335 controls of Japanese ancestry.
Endometriosis and in vitro fertilisation: a review by Hervé Déchaud, Clotilde Dechanet et al."Endometriosis and in vitro fertilisation: a review" by Hervé Déchaud, Clotilde Dechanet et al.
This review aims to evaluate whether severe endometriosis has an impact on the outcome of in vitro fertilisation (IVF), whether IVF is associated with specific complications in this context, whether a specific ovarian stimulation protocol is most appropriate, whether the endometrial condition progresses following ovarian stimulation, and whether endometrial cysts pose a specific problem for IVF. In patients with severe endometriosis, IVF represents an effective treatment option for infertility, as a complement to surgery. The prognostic parameters of IVF are identical to those of other patients. However, the risks related to the severity of endometriosis, particularly the risk of ovarian deficiency, need to be considered. Because of this issue, to which endometriosis-related pain often adds, IVF treatment should be initiated as early as possible, using appropriate protocols and after having fully informed the patient about the specific oocytes retrieval-related risks.
CO2 Laser to Remove Endometriosis Lesions Presented by LumenisCO2 Laser to Remove Endometriosis Lesions Presented by Lumenis
Read more about Lumenis innovative and precise CO2 laser technology to remove endometriosis lesions, presented an annual gynecological meeting.
Endometrioma/FertilitypediaEndometrioma/Fertilitypedia
Endometriomas can occur unilaterally or bilaterally, and approximately 28% of endometriomas are bilateral. Ovarian endometriomas are usually associated with the symptoms of dysmenorrhoea (painful menstruation), chronic pelvic pain, dyspareunia (painful sexual intercourse), and infertility. Endometrioma is one of the most common manifestations of endometriosis. Endometriosis is a benign, estrogen-dependent disease characterized by endometrial tissue located outside the uterus. The main pathological processes associated with endometriosis are peritoneal inflammation and fibrosis (scarring) and the formation of adhesions (fibrous tissue patches, attaching structures together) and endometriomas (benign ovarian cysts). Endometriosis is linked to pelvic pain, though it is sometimes completely asymptomatic, and infertility. While in itself a benign lesion, endometriosis shares several characteristics with invasive cancer, has been shown to undergo malignant transformation, and has been associated with ...
EndometriosisEndometriosis
Why Do I Need To Know About Endometriosis?. Endometriosis is a common disease that can affect any menstruating woman from the time of her first period to menopause. Sometimes, the disease can last after menopause.. What is endometriosis?. When a woman has endometriosis, the tissue that lines her uterus, called the endometrium, grows outside of the uterus. No one is sure why this happens. When this tissue grows outside of the uterus, it is mostly found in the pelvic cavity, usually in one or more of these places: on or under the ovaries, behind the uterus, on the tissues that hold the uterus in place, or on the bowels or bladder. In very rare cases, endometriosis areas can grow in the lungs or other parts of the body.. As the tissue grows, it can develop into growths, also called tumors or implants. These growths are usually benign (not cancerous) and are rarely associated with cancer. Growths can cause mild to severe pain, infertility , and heavy periods.. The endometriosis growths are affected ...
Deep Pelvic Endometriosis | Springer for Research & DevelopmentDeep Pelvic Endometriosis | Springer for Research & Development
Deep pelvic endometriosis is one of the most severe expressions of a disease that may involve all the pelvic organs - bladder, ureters, rectosigmoid colon - causing debilitating symptoms and leading t
Elagolix for Endometriosis Pain Gets Positive Reports from AbbVie in Early Results of Second Phase 3 Trial - Endometriosis NewsElagolix for Endometriosis Pain Gets Positive Reports from AbbVie in Early Results of Second Phase 3 Trial - Endometriosis News
These preliminary results represent a six-month, group-level analysis. Participants in the Phase 3 trial will continue with either post-treatment follow-up or as part of a blinded six-month extension study to provide additional evaluation of Elagolix safety and efficacy. AbbVie says it also intends to present detailed results from the two Phase 3 trials at an unspecified 2016 medical conference. To date, Elagolix has been the subject of more than 40 clinical trials totaling more than 3,000 subjects, including several in patients with endometriosis and uterine fibroids, and AbbVie says it will now work on completing a clinical database in final preparation of a New Drug Application submission for Elagolix as a treatment for endometriosis anticipated in 2017.. Endometriosis. According to The World Endometriosis Research Foundation, the Mayo Clinic, and other authorities, endometriosis is a disorder in which tissue similar to the lining inside the uterus (called the endometrium), is found in ...
endometriosis : Laparoscopy of Adhesiolysisendometriosis : Laparoscopy of Adhesiolysis
Symptoms after endometriosis surgery are mostly related to adhesions! Your surgery was performed by an endometriosis expert and you still have symptoms, so you should know that in most cases it is not endometriosis anymore, as endometriosis was cured by your expert endometriosis surgeon performing radical excision of the endometriosis spots.You now are dealing with adhesions, […]. ...
Cellular and molecular basis for endometriosis-associated infertility.Cellular and molecular basis for endometriosis-associated infertility.
Endometriosis is a gynecological disease characterized by the presence of endometrial glandular epithelial and stromal cells growing in the extra-uterine environment. The disease afflicts 10%-15% of menstruating women causing debilitating pain and in
endometriosis - Postsendometriosis - Posts
endometriosis - MedHelps endometriosis Center for Information, Symptoms, Resources, Treatments and Tools for endometriosis. Find endometriosis information, treatments for endometriosis and endometriosis symptoms.
endometriosis tissueendometriosis tissue
What is Endometrial Ablation for the management of endometriosis or ovarian cysts? For a patient with endometriosis, and especially when ovarian cysts related to endometriosis are found (an endometrioma), managing endometriosis and ovarian cysts is effective for both reducing pain … Continue reading →. ...
Initial Endometriosis: Zheng Lab - UT Southwestern, Dallas, TXInitial Endometriosis: Zheng Lab - UT Southwestern, Dallas, TX
Endometriosis is one of the most commonly encountered gynecologic disorders, but the pathogenesis remains to be elucidated. Several theories relating to the pathogenesis of endometriosis have been proposed.. The most widely cited theory, the transplantation theory by retrograde menstruation, was proposed in 1927 by Sampson, who observed that endometrial cells regurgitated through the fallopian tubes during menstruation.. The celomic metaplasia hypothesis proposed by Meyer states that the original celomic membrane undergoes metaplasia, forming typical endometrial glands and stroma. The celomic metaplasia theory is supported by the description of cases of endometriosis in which retrograde menstruation does not occur and cannot be explained by Sampsons theory.. For instance, endometriosis was described in the prostatic utricle of men with prostatic carcinoma undergoing high-dose estrogen therapy, in whom there is no endometrium to be a source of endometriotic cells.. The development of pelvic ...
Endometriosis by hanin muhsen on PreziEndometriosis by hanin muhsen on Prezi
If the history and pelvic exam suggest endometriosis, the next step may involve a procedure called laparoscopy. With this procedure, a tiny cut is made near the navel and a thin tube inserted. This tube (the laparoscope) is an illuminated microscope that enables the doctor to clearly see the endometriosis on the outer surfaces of the pelvic organs. The doctor may take a tissue sample during a laparoscopy and a pathologist examines the tissue sample to confirm if endometriosis was found. Laparoscopy can also be used to treat endometriosis, using a laser or electricity to burn off the endometrial tissue ...
Dysmenorrhea, infertility, endometriosis! Sohu - yuanmu | minmi,yezimei,执魔,七星彩走势图,苗疆道事,cctv6节目表,无限道武者路,前鼻韵母,梁逸峰Dysmenorrhea, infertility, endometriosis! Sohu - yuanmu | minmi,yezimei,执魔,七星彩走势图,苗疆道事,cctv6节目表,无限道武者路,前鼻韵母,梁逸峰
Dysmenorrhea, infertility, endometriosis! Endometriosis is one of the most common benign diseases in women of childbearing age. A conservative estimate of 10% women of childbearing age. About 50% of women with infertility are associated with the disease, and the incidence of women with pelvic pain is as high as 70%. First, what is endometriosis? Endometriosis, refers to the presence of active endometrial tissue outside the endometrium, the most common location of the ovary, pelvic peritoneum, etc.. Age is the age of endometriosis, 76% 25-45 years old, female fertility and birth incidence less late was significantly higher. The three major hazards of endometriosis are infertility, dysmenorrhea, endometriosis and chocolate cyst. Two, to be alert to these symptoms of endometriosis endometriosis: a variety of clinical manifestations, pathological changes, clinical manifestations are not the same, the most common symptoms are as follows: 1: dysmenorrhea dysmenorrhea is the most typical symptoms of ...
Laparoscopic ileocecal resection for bowel endometriosis<...Laparoscopic ileocecal resection for bowel endometriosis<...
TY - JOUR. T1 - Laparoscopic ileocecal resection for bowel endometriosis. AU - Ruffo, Giacomo. AU - Stepniewska, Ania. AU - Crippa, Stefano. AU - Serboli, Giacomo. AU - Zardini, Claudio. AU - Steinkasserer, Martin. AU - Ceccaroni, Marcello. AU - Minelli, Luca. AU - Falconi, Massimo. PY - 2011/4. Y1 - 2011/4. N2 - Background: Ileocecal endometriosis is a very rare entity, and its diagnosis is usually made during surgery for other endometriosis sites or, rarely, because of direct complications of ileal involvement. This study was designed to analyze perioperative and long-term outcomes after bowel resection for ileocecal endometriosis. Methods: All patients who underwent surgery for ileocecal endometriosis between October 2004 and January 2008 were prospectively collected and analyzed. Results: Thirty-one women (median age, 34 (range, 25-40) years) were identified. Ileocecal endometriosis was diagnosed during surgery in all patients, and it was associated with colorectal endometriosis in 29 ...
Chronic abdominal pain, appendiceal mucinous neoplasm, and concurrent intestinal endometriosis: a case report | Journal of...Chronic abdominal pain, appendiceal mucinous neoplasm, and concurrent intestinal endometriosis: a case report | Journal of...
Although both appendiceal tumor and intestinal endometriosis have been reported as rare causes of abdominal pain, the coexistence of appendiceal mucinous neoplasm and ileal endometriosis has not previously been reported. A 41-year-old Japanese woman presented with a positive fecal occult blood test and a 3-year history of menstruation-related lower abdominal pain. A colonoscopy demonstrated extrinsic compression of the cecum, suggesting a mass arising from the appendix or adjacent structures. Abdominal imaging showed a 6-cm cystic mass with intraluminal thick fluids originating from the appendix. At ileocecal resection for an appendiceal tumor, a 2-cm mass in the terminal ileum was incidentally found, which was included in the surgical specimen. Microscopic examination confirmed a diagnosis of a mucinous neoplasm of the appendix with endometriosis of the terminal ileum. To avoid urgent surgery for subsequent serious events associated with disease progression, appendiceal tumor and intestinal
Media: Endometriosis Misinformation (Edited) - ChronicHealing.comMedia: Endometriosis Misinformation (Edited) - ChronicHealing.com
As a patient who has lived with endometriosis for 27 years, I feel compelled to point out an inaccuracy in this column. This quote is incorrect:. "A simple pelvic examination would have quickly pin-pointed the diagnosis, endometriosis".. As per the Endometriosis Association, "Diagnosis is considered uncertain until proven by laparoscopy, a minor surgical procedure done under anesthesia. A laparoscopy usually shows the location, size, and extent of the growths. This helps the doctor and patient make better treatment choices".. This Intelligencer article came to my attention because it was picked up as a "Google Alert" for the topic of "endometriosis". (That means many people are being exposed to the inaccurate info included in this article). So, I received an email from Google that linked me here.. The incorrect quote above immediately drew my attention because it is this type of misinformation in the media that has hurt so many endometriosis patients for so many years.. I hope that the ...
Global Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis<...Global Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis<...
TY - JOUR. T1 - Global Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis. AU - Herndon, Christopher N.. AU - Aghajanova, Lusine. AU - Balayan, Shaina. AU - Erikson, David. AU - Barragan, Fatima. AU - Goldfien, Gabriel. AU - Vo, Kim Chi. AU - Hawkins, Shannon. AU - Giudice, Linda C.. PY - 2016/10/1. Y1 - 2016/10/1. N2 - Objective: Adenomyosis is a clinical disorder defined by the presence of endometrial glands and stroma within the myometrium, the pathogenesis of which is poorly understood. We postulate that dysregulation of genes and pathways in eutopic endometrium may predispose to ectopic implantation. No study, to our knowledge, has examined the global transcriptome of isolated eutopic endometrium from women with clinically significant adenomyosis. Design: Laboratory-based study with full institutional review board approval and consents. Material and Methods: Endometrial sampling was performed on hysterectomy specimens (proliferative phase) from symptomatic ...
Contralateral ovarian endometrioma recurrence after unilateral salpingo-oophorectomy | BMC Womens Health | Full TextContralateral ovarian endometrioma recurrence after unilateral salpingo-oophorectomy | BMC Women's Health | Full Text
The recurrence rate after unilateral salpingo-oophorectomy (USO) for unilateral endometrioma has not been reported. We evaluated the rate of and risk factors for endometrioma recurrence after USO. In this retrospective observational study, we enrolled 110 women (age, 35-45 years) who underwent laparoscopic USO (n = 50) or cystectomy (n = 60) for unilateral ovarian endometrioma from January 2010 through December 2012. We compared patients characteristics between patients who underwent USO and those who underwent cystectomy. We also compared patients with and without an endometrioma recurrence after USO using univariate and multivariate stepwise logistic regression models to identify recurrence risk factors. Endometrioma recurrence was defined as an ovarian cyst (| 2 cm) with features typical of an endometrioma identified by postoperative transvaginal sonography. Endometrioma recurred in 8 (16%) patients after USO (mean follow-up, 46.0 ± 12.9 months [range, 15-73]). The post-USO cumulative recurrence
Endometriosis EXPLAINED - Understanding chronic pelvic pain with or without endometriosisEndometriosis EXPLAINED - Understanding chronic pelvic pain with or without endometriosis
Endometriosis" describes deposits of ectopic endometrium outside the uterus. Traditionally, gynaecologists believe that these "deposits" of endometrium bleed during your period and cause pain. A better explanation is that the pain is caused by injuries to your pelvic nerves and the endometrium simply attaches to areas of injury in your pelvis. These injuries are caused by difficult first labours, straining on the toilet, and, gynaecological surgery (GS Atwal, 2005).. "Endometriosis" was first described in 1860 though it has had many reincarnations since that date. The theory associated with deposits of ectopic endometrium has, therefore, had 150 years to cement itself into medical minds and habits. Injured nerves were discovered in 2005 ! So it is going to take a little while to change hearts and minds ? And it is not going to be easy because many doctors make very large sums of money ablating, or excising, ectopic endometrium.. What is the evidence that ectopic endometrium causes "cyclical, ...
Risk factors for recurrence rate of ovarian endometriomas following a laparoscopic cystectomy - Minerva Medica 2014 August;105...Risk factors for recurrence rate of ovarian endometriomas following a laparoscopic cystectomy - Minerva Medica 2014 August;105...
METHODS: A cross-sectional study was performed at Arash University Hospital between 2009 and 2011 on patients who had a minimum of one year of postoperative follow-up after undergoing a laparoscopic excision of an ovarian endometrioma. The patients had any prior surgery for ovarian endometriomas was excluded. Recurrence was defined as the presence of endometrioma more than 2 cm in size, detected by ultrasonography within 1 year of surgery. The variables including age at surgery, presence of infertility, uterine myoma, previous medical treatment of endometriosis, the size of the largest cyst at laparoscopy, unilateral or bilateral involvement, serum CA125 level, revised American Society for Reproductive Medicine (ASRM) score and stage, postoperative medical treatment and postoperative treatment were evaluated to assess their independent effects on the recurrence using logistic regression analysis ...
Endometriosis Gorham ME - tTTC, Gorham ME trying to conceive, Gorham ME endometriosis, Gorham ME adhesions, Gorham ME ...Endometriosis Gorham ME - tTTC, Gorham ME trying to conceive, Gorham ME endometriosis, Gorham ME adhesions, Gorham ME ...
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Are gonadotropin-releasing hormone analogs and laparoscopic ablation equally effective treatments for endometriosis?Are gonadotropin-releasing hormone analogs and laparoscopic ablation equally effective treatments for endometriosis?
Although both laparoscopic ablation and gonadotropin-releasing hormone analogs (GnRHa) are treatments for endometriosis, there are no studies that directly compare these two treatment options. METHODS: This study compares the use of GnRHa therapy and laparoscopic ablation concerning symptom relief, recurrence of symptoms, safety, side effects of treatment and improvement of quality of life in women ages 18-50 with diagnosed endometriosis. The study design is an evidence-based literature review, assessing each study for its research design, inclusion and exclusion criteria, treatment results, adverse affects and conclusions. RESULTS: All but one research study showed that GnRHa are effective at improving quality of life by relieving endometriosis symptoms up to one year post treatment. Side effects were consistent with hypoestrogenemia and were non-life threatening. Laparoscopic ablation was found to successfully treat endometriosis symptoms, but fertility rates were not consistently improved. ...
Endometriosis Ayurvedic Treatment | Endometriosis Herbal SupplementsEndometriosis Ayurvedic Treatment | Endometriosis Herbal Supplements
Ayurvedic treatment for endometriosis is the safest way to get relief from the symptoms of endometriosis like heavy bleeding and severe pelvic pain etc. The herbal ayurvedic treatment has proven its efficacy in contrast to NSAIDS and hormonal therapy, which are widely used for treating endometriosis.
Women Health: Endometriosis: The Effects of Chinese herb Corydalis ambiguaWomen Health: Endometriosis: The Effects of Chinese herb Corydalis ambigua
During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period ...
Women Health: Endometriosis: The Effects of Chinese herb VerbenaWomen Health: Endometriosis: The Effects of Chinese herb Verbena
During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period ...
Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies -...Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies -...
Objective: To review published studies evaluating early menarche and the risk of endometriosis. Design: Systematic review and meta-analysis of case-control studies. Setting: None. Patient(s): Eighteen case-control studies of age at menarche and risk of endometriosis including 3,805 women with endometriosis and 9,526 controls. Intervention(s): None. Main Outcome Measure(s): Medline and Embase databases were searched from 1980 to 2011 to locate relevant studies. Results of primary studies were expressed as effect sizes of the difference in mean age at menarche of women with and without endometriosis. Effect sizes were used in random effects meta-analysis. Result(s): Eighteen of 45 articles retrieved met the inclusion criteria. The pooled effect size in meta-analysis was 0.10 (95% confidence interval -0.01-0.21), and not significantly different from zero (no effect). Results were influenced by substantial heterogeneity between studies (I 2 = 72.5%), which was eliminated by restricting meta-analysis to
Adenomyosis - HERS FoundationAdenomyosis - HERS Foundation
Adenomyosis is endometriosis interna, the growth of endometrial implants into the wall of the uterus. It is different from endometriosis, which is endometrial tissue that migrates and implants outside of the uterus into the pelvis.. Between menstrual cycles the inside lining of the uterus, the endometrium, proliferates and continues to thicken until it sheds during menstruation. Adenomyosis occurs when endometrial tissue grows into the middle, muscular wall of the uterus, the myometrium, and sometimes the exterior wall of the uterus, the subserosal layer.. Some women with adenomyosis do not experience any symptoms, while others may have severe, debilitating symptoms.. Endometrial implants that grow into the wall of the uterus bleed during menstruation, the same as endometrial tissue bleeds and is discharged vaginally as menstrual bleeding. Endometrial implants may cause pain or pressure in the pelvis and vagina, as well as a heavy menstrual flow without large blood clots. The vaginal pressure ...
Endometriosis Hickory NC - pregnant, Hickory NC PREGNANCY, Hickory NC pregnancy, Hickory NC baby, Hickory NC breast pumps,...Endometriosis Hickory NC - pregnant, Hickory NC PREGNANCY, Hickory NC pregnancy, Hickory NC baby, Hickory NC breast pumps,...
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Endometriosis Brattleboro VT - pregnant, Brattleboro VT PREGNANCY, Brattleboro VT pregnancy, Brattleboro VT baby,...Endometriosis Brattleboro VT - pregnant, Brattleboro VT PREGNANCY, Brattleboro VT pregnancy, Brattleboro VT baby,...
Looking for information on Endometriosis in Brattleboro? We have compiled a list of businesses and services around Brattleboro that should help you with your search. We hope this page helps you find information on Endometriosis in Brattleboro.
Endometriosis: What you need to know - Designs for Wellness™ - Samuel Tyuluman, M.D.Endometriosis: What you need to know - Designs for Wellness™ - Samuel Tyuluman, M.D.
Diagnosis is considered uncertain until proven by laparoscopy, a minor surgical procedure done under anesthesia. A laparoscopy usually shows the location, size, and extent of the growths. This helps the doctor and patient make better treatment choices.. What Causes Endometriosis?. The cause of endometriosis is unknown. The retrograde menstruation theory (transtubal migration theory) suggests that during menstruation some of the menstrual tissue backs up through the fallopian tubes, implants in the abdomen, and grows. Some experts believe that all women experience some menstrual tissue backup and that an immune system problem or a hormonal problem allows this tissue to grow in the women who develop endometriosis.. Another theory suggests that endometrial tissue is distributed from the uterus to other parts of the body through the lymph system or through the blood system. A genetic theory suggests that it may be carried in the genes in certain families or that some families may have predisposing ...
Stop Endometriosis and Pelvic Pain: What Every Woman and Her Doctor Need to Know - Andrew S Cook, Robert Franklin | FeedbooksStop Endometriosis and Pelvic Pain: What Every Woman and Her Doctor Need to Know - Andrew S Cook, Robert Franklin | Feedbooks
Stop Endometriosis and Pelvic Pain provides extensive information about the realities and the myths of endometriosis and pelvic pain and various treatments for the disease. This book is ideal for someone with endometriosis or pelvic pain or for someone with family members or friends who need information and support regarding every aspect of the disease.
Bibliografia 2017 - Pagina 153 - Endometriosi.itBibliografia 2017 - Pagina 153 - Endometriosi.it
J Obstet Gynaecol Res. 2017 Apr;43(4):736-743.. Increased ipsilateral uterine artery vascular resistance in women with ovarian endometrioma.. Waratani M1, Mori T1, Ito F1, Tanaka Y1, Koshiba A1, Takahata A2, Kitawaki J1.. Abstract. AIM:. The aim of this study was to elucidate whether the presence of an ovarian endometrioma is associated with impaired vascular flow. We investigated changes in vascular flow on the ipsilateral and contralateral side of the endometrioma, before and after surgery.. METHODS:. This prospective case-control study included 144 women (ovarian endometrioma [n = 40], endometriosis without ovarian endometrioma [n = 33], non-endometriotic ovarian cyst [n = 17], and normal pelvis [n = 54]). The uterine artery (UtA) vascular resistance indices (pulsatility index [PI] and resistance index [RI]) were measured using transvaginal Doppler sonography, and UtA diameters were measured using magnetic resonance imaging.. RESULTS:. The UtA PI and RI were significantly higher on the ...
Order Generic for Cyclomen (Danazol) for Endometriosis at InternationalDrugMartOrder Generic for Cyclomen (Danazol) for Endometriosis at InternationalDrugMart
Generic for Cyclomen 50mg, 100mg and 200mg capsules are used to treat endometriosis. Order at InternationalDrugMart and save upto $46.36
Prevalence of endometriosis at a university hospital in Jeddah, Saudi Arabia.Prevalence of endometriosis at a university hospital in Jeddah, Saudi Arabia.
CONCLUSION: Endometriosis was uncommon in women who had undergone gynecologic laparoscopy. PMID: 26753486 [PubMed - in process]...
Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosisEffect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis
In endometriosis, the increased survival potential of shed endometrial cells (which normally undergo anoikis) is suggested to promote lesion development. One mechanism that may alter anoikis is autophagy. Using an autophagic flux inhibitor hydroxychloroquine (HCQ), we identified that it reduces the in vitro survival capacity of human endometriotic and endometrial T-HESC cells. We also identified that HCQ could decrease lesion numbers and disrupt lesion histopathology, as well as increase the levels of peritoneal macrophages and the IP-10 (10 kDa interferon-γ-induced protein) chemokine in a mouse model of endometriosis. We noted that RNA levels of a subset of autophagic markers were reduced in lesions relative to uterine horns from endometriosis-induced (untreated) mice. In addition, the RNA levels of autophagic markers were decreased in uterine horns of endometriosis-induced mice compared with those from controls. However, we noted that protein expression of LC3B (microtubule-associated protein ...
top chef las vegas - Snark Foodtop chef las vegas - Snark Food
Model, author, and Emmy-nominated Padma Lakshmi confirms that she is carrying her first child after years of struggling with endometriosis, a cause for which she has co-founded the Endometriosis Foundation of America," the Top Chef hosts rep told Us Weekly.. Endometriosis can be a serious medical condition which causes the lining of the uterus to grow in other parts of the body. Endometriosis can also cause infertility and severe pain.. "As a result of her condition, this pregnancy has been referred to by her physician as nothing short of a medical miracle, and due to its delicate nature, we ask/implore the press to respect Ms. Lakshmis privacy at this time," Lakshmis rep said.. Padma Lakshmi has not revealed who is the father of the baby. Lakshmi was formerly married for three years to author Salman Rushdie, but split with him in 2007.. ...
Demographic, biological and dietary characteristics associated with endometriosis in a group of Sri Lankan womenDemographic, biological and dietary characteristics associated with endometriosis in a group of Sri Lankan women
OBJECTIVE: To identify demographic, biological and dietary factors associated with endometriosis in a group of Sri Lankan women. METHODS: A case-control study was conducted at two tertiary care hospitals. Women with endometriosis (n=150) were compared with age-matched controls (n=150) with no evidence of endometriosis, both confirmed by laparoscopy or laparotomy. Data were collected using an interviewer-administered questionnaire and a food frequency questionnaire. Means were compared using paired t-tests and chi square tests and odds ratios (OR) were used to determine associations between dichotomous variables. Conditional logistic regression analysis was done to adjust for potential confounding variables. RESULTS: The ethnic distribution, age at menarche, average length of the menstrual cycle and body mass index were similar in the two groups. The mean (+SD) duration of menstruation in the cases (4.11±0.11 days) was significantly higher than in the controls (3.47±0.16 days, p=0.01). ...
Non-steroidal anti-inflammatory drugs for pain in women with endometriosis. - Oxford Clinical Trials Research UnitNon-steroidal anti-inflammatory drugs for pain in women with endometriosis. - Oxford Clinical Trials Research Unit
BACKGROUND: Endometriosis is a common gynaecological condition that affects women and can lead to painful symptoms and infertility. It affects womens quality of life greatly, impacting on their careers, everyday activities, sexual and non-sexual relationships, and fertility. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used first-line treatment for endometriosis. OBJECTIVES: To assess the effects of NSAIDs for the management of pain in women with endometriosis compared to placebo, other NSAIDs, other pain management drugs, or no treatment. SEARCH STRATEGY: We searched the Cochrane Menstrual Disorders and Subfertility Group Specialised Trials Register (May 2005) published in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to May 2005), EMBASE (1980 to May 2005) and the reference lists from relevant publications. Experts in the field were also contacted for information about possible studies. SELECTION CRITERIA: We included all randomized controlled
Stages of Endometriosis - North Kansas City Hospital, Kansas City, MOStages of Endometriosis - North Kansas City Hospital, Kansas City, MO
Staging is a way of describing how mild or severe a condition is. The stage of the endometriosis is determined by looking at the uterus, fallopian tubes, and ovaries and inside the abdomen and lower pelvic area. Usually, this is done with a viewing instrument inserted through a small incision in the belly (laparoscopy). But endometriosis is sometimes first found during surgery for an unrelated condition. Endometriosis is classified in four stages:. ...
Endometriosis Tied to Adverse Pregnancy Outcomes | Physicians WeeklyEndometriosis Tied to Adverse Pregnancy Outcomes | Physician's Weekly
Leslie V. Farland, Sc.D., from University of Arizona in Tucson, and colleagues evaluated the relationship between endometriosis and adverse pregnancy outcomes (miscarriage, ectopic pregnancy, stillbirth, gestational diabetes mellitus [GDM], hypertensive disorders of pregnancy, preterm birth, and low birth weight) among 116,429 women participating in the Nurses Health Study II.. The researchers identified a total of 196,722 reported pregnancies. There was an association noted between endometriosis and a greater risk of pregnancy loss (miscarriage: relative risk, 1.40; ectopic pregnancy: relative risk, 1.46). There was also a greater risk of GDM (relative risk, 1.35) and hypertensive disorders of pregnancy (relative risk, 1.30) associated with endometriosis.. "Future research should focus on the potential biological pathways underlying these relationships to inform screening or preventive interventions," the authors write.. Abstract/Full Text (subscription or payment may be required). Copyright ...
Padma Lakshmi Expecting Her First Child Despite Struggle With Endometriosis | BabyrazziPadma Lakshmi Expecting Her First Child Despite Struggle With Endometriosis | Babyrazzi
In the above pic an expectant Padma was snapped at the 61st Annual Primetime Emmy Awards in LA). Top Chef host Padma Lakshmi is pregnant, her rep has confirmed.. "Model, author, and Emmy-nominated Padma Lakshmi confirms that she is carrying her first child after years of struggling with endometriosis, a cause for which she has co-founded the Endometriosis Foundation of America," the rep told Us magazine of Padma, 39.. "As a result of her condition, this pregnancy has been referred to by her physician as nothing short of a medical miracle, and due to its delicate nature, we ask/implore the press to respect Ms. Lakshmis privacy at this time," the rep continued.. Endometriosis is a medical condition in which the uterus lining grows in other areas of the body, causing pain, irregular bleeding and possible infertility.. The babys father has not been revealed. Online reports have speculated Manu Nathan is the father, but her rep denied that, explaining that he is Padmas cousin.. Padma split from ...
Endometriosis And Fertility Natural TreatmentEndometriosis And Fertility Natural Treatment
Endometriosis and fertility are definitely connected. Effective natural treatments for endometriosis symptoms and endometriosis causes.
Endometriosis Stages - Cure for EndometriosisEndometriosis Stages - Cure for Endometriosis
Endometriosis Stages - As of now, a sure-fire cure for endometriosis is still being tested. However, modern science has provided us with medications and...
Ayurvedic Treatment for Endometriosis Archives - ParijatakAyurvedic Treatment for Endometriosis Archives - Parijatak
Connect with Parijatak for Endometriosis Treatment in Ayurveda Nagpur Ayurvedic Cure for Endometriosis, Endometriosis is a very painful gynaecological condition […] ...
High-Grade Serous Carcinoma Resulting From Rectal Endometriosis and Complicated With Ovarian CancerHigh-Grade Serous Carcinoma Resulting From Rectal Endometriosis and Complicated With Ovarian Cancer
We report a rare case of high-grade serous carcinoma resulting from rectal endometriosis and complicated with ovarian cancer. A 63-year-old Chinese woman was admitted with a complaint of abdominal distension. We diagnosed the patient with ovarian carcinoma and decided on elective cytoreductive surgery as treatment for the patient. During the surgery, we found a solid mass of diameter 12 cm in the ...
077 Ectopic endometriosis in neurological practice | Journal of Neurology, Neurosurgery & Psychiatry077 Ectopic endometriosis in neurological practice | Journal of Neurology, Neurosurgery & Psychiatry
Ectopic endometriosis by definition describes presence of functioning ectopic endometrium outside the uterus. Author presents two cases of ectopic endometriosis causing focal neurological symptoms. 42 years old woman, with past medical history of IBS, Psoriasis, Asthma and diverticular disease, following insertion of IUD she presented with pelvic pain. Diagnosed after laparoscopy with positive histology at age of 20. Recently she developed recurrent catamenial pain in buttocks radiating down to left calf in L5 dermatoma and bilateral foot pain and tenderness when walking, she was referred to neurology clinic. Symptoms responded to treatment with GnRH agonists. Patient developed side effects and symptoms recurred when treatment was discontinued. Since complete hysterectomy with ovarectomy symptoms gradually improved. Generally healthy 28-years-old female with few year history of dysmenorrhoea presented with 6 months history of episodic pins and needles, pain in buttocks and weakness of both legs ...
Genetic Determinants of Endometriosis and Uterine Myoma Combinatin - HelixGenetic Determinants of Endometriosis and Uterine Myoma Combinatin - Helix
The relevance of benign proliferative diseases of the uterus, which include uterine myoma and endometriosis, is associated with a fairly high prevalence and comorbidity of these pathological conditions due to the common etiology and pathogenesis, which explains a similar in most cases clinical pattern.. Endometriosis is a process when benign proliferation of tissue occurs outside the uterine cavity, similar to the endometrium in the morphological and functional properties [Bruner-Tran K.L. et al., 2013]. This disease occurs in 10% of women of reproductive age [Rahmioglu N. et al., 2015] and is one of the main causes of infertility, dysmenorrhea, dyspareunia, as well as chronic pelvic pain, adhesion of the pelvic organs, which together leads to a general deterioration quality of life of women [Truskinovsky A.M. et al., 2014; Ponomarenko I.V. et al., 2016].. Uterine myoma is one of the most common female genital benign tumors that occurs in 20-40% of women of reproductive age [Churnosov M.I. et ...
Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular...Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular...
OBJECTIVE: To investigate the antiangiogenesis mechanism of epigallocatechin-3-gallate (EGCG) in an endometriosis model in vivo. DESIGN: Animal studies. SETTING: University laboratory. ANIMAL(S): Human endometrium from women with endometriosis (n = 10) was transplanted into immunocompromised mice. INTERVENTION(S): Mice (n = 30) were randomly treated with EGCG, vitamin E (antioxidant control), or vehicle (negative control) for microvessel imaging. MAIN OUTCOME MEASURE(S): Endometriotic implants were collected for angiogenesis microarray and pathway analysis. Differentially expressed angiogenesis molecules were confirmed by quantitative polymerase chain reaction, Western blot, and immunohistochemistry. Effects of EGCG on angiogenesis signal transduction were further characterized in a human endothelial cell line. Microvessel parameters and the angiogenesis signaling pathway in endometriotic implants and endothelial cells were studied. RESULT(S): EGCG, but not vitamin E, inhibited microvessels in
Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal...Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal...
The pharmaceutical actions of DNG on the expression of aromatase and COX-2 and the production of PGE2 were examined using spheroid cultures of human ESCs. More aromatase, COX-2, and PGE2 were expressed in spheroid cultures than in conventional ESCs monolayers. In the spheroid cultures, DNG (10−7 M) and progesterone (10−7 M) inhibited the expression of aromatase, COX-2, and PGE2. DNG also inhibited NF-κB DNA-binding activity and reduced the immunocytochemical protein expression of aromatase, COX-2, and NF-κB p50 nuclear localization.. Conclusion(s): ...
Airing the Chapel: Coming to a conclusion, sort ofAiring the Chapel: Coming to a conclusion, sort of
In early endometriosis (Stage I-II), the mechanism of infertility is less clear and more complex. Studies from our Institute for the Study and Treatment of Endometriosis (Endometriosis Institute) and from other centers have shown that in endometriosis, the intraperitoneal environment, through a variety of mechanisms, prevents conception. It has been demonstrated that the peritoneal fluid from women with endometriosis contains different biochemical substances with anti-fertility effects. These substances produced by the endometriotic cells or cells of the immune system include several prostaglandins with smooth muscle contracting properties, various cytokines, abnormal autoantibodies, and reactive oxygen radicals. They can prevent ovulation by inducing early LUF (luteinized unruptured follicle) Syndrome; others prevent egg capture by the fimbria of the fallopian tube, interfere with tubal function and its ability to transport gametes and embryos, interfere with hormone production by the corpus ...
WAVES OF WELLNESS: Dont ignore pelvic painWAVES OF WELLNESS: Don't ignore pelvic pain
About 7 to 10 percent of women in their lifetime will be diagnosed with endometriosis, but that rate is even higher - up to 80 percent - for patients with chronic pelvic pain. The exact incidence of the disease is thought to be underestimated because the only way to positively diagnose endometriosis is by laparoscopy, a minimally invasive surgery. Many women will never know they have endometriosis because they think they have to live with the pain.. Endometriosis is a condition in which tissue, similar to the cells of the lining of the uterus, grow in other areas of the body. The most commonly affected areas are the ovaries, bowel or the lining of the pelvis. This abnormal growth can cause pelvic pain, irregular bleeding and infertility.. Since the growth of endometriosis depends on the presence of estrogen, the disease impacts women of reproductive age. Most women are diagnosed in their 20s.. Symptoms include chronic pelvic pain, painful menstruation, irregular vaginal bleeding and pain with ...
When Your Pelvic Pain Is Not Normal: Tips for Managing Endometriosis [Sponsored] | Everyday HealthWhen Your Pelvic Pain Is Not Normal: Tips for Managing Endometriosis [Sponsored] | Everyday Health
Painful periods, severe pelvic pain, and pain during sex can be signs of endometriosis, a chronic condition that affects 1 in 10 women of reproductive age. Learn about endometriosis treatment, including the newest medication, ORILISSA® (elagolix).
Natural Cures for Endometriosis and Fibroids | Michigan Associates of Acupuncture and Integrative MedicineNatural Cures for Endometriosis and Fibroids | Michigan Associates of Acupuncture and Integrative Medicine
Both Endometriosis and Fibroids are influenced by hormones. Endometriosis is the result of abnormal growth of endometrial tissue outside of the endometrium (the
4/22/20134/22/2013
... 1. A father brings his daughter in for a health supervision visit. She skips (alternating feet) into the room. You give her a piece of paper and a crayon and ask her to draw a person. She proudly draws a person with 6 body parts. You ask her to take off her shoes and sweater in order to obtain an accurate weight and she quickly complies with your request. Of the following, the age that BEST describes this childs developmental abilities is A) 2 years old B) 3 years old C) 4 years old D) 5 years old E) 6 years old Correct answer(s): D 2. A mother of a patient in your practice reports that she is currently 8 weeks pregnant and just discontinued use of danazol, which she was taking for treatment of severe endometriosis. She has been told that use of this medication in the first trimester of pregnancy can be associated with birth defects and wishes to know what possible birth defects can be seen with use of this medication in pregnancy.Of the following, you are MOST likely to tell her that ...
WJPMR | AbstractWJPMR | Abstract
MD Dr. Raziye Desdicioglu*, MD Melahat Yildirim, MD Gamze Avcioglu, MD Emre Erdem Tas MD Özlem Şengul, MD Ozcan Erel and MD Ayse Filiz Yavuz. ABSTRACT. Introduction: The aim was to compare serum soluble urokinase plasminogen activator receptor (suPAR) and interleukin-6 (IL-6) levels between patients with and without endometriosis. Materials and Methods: Twenty two women with endometriosis and 25 healthy women were included in the study. Serum suPAR and IL-6 levels were assessed with the ELISA method. For statistical methods, t test and Receiver Operating Characteristic - ROC analysis were used. Results: Serum suPAR level was measured as 0.38±0.48ng/ml in the endometriosis group and as 0.16±0.11ng/ml in the control group ( ...
Uterine Fibroids, Endometriosis, and Thyroid HealthUterine Fibroids, Endometriosis, and Thyroid Health
Many women with thyroid and autoimmune thyroid conditions have uterine fibroids and endometriosis. These are both usually found in premenopausal women, and problems with estrogen metabolism is a big factor, although inflammation also plays a role in their development. And since chronic inflammation is a factor in autoimmune conditions such as Graves Disease and Hashimotos Thyroiditis, people with thyroid autoimmunity are more likely to develop uterine fibroids and/or endometriosis.
Uterine Fibroids or Endometriosis Paid Clinical Study at Totally Free StuffTotally Free StuffUterine Fibroids or Endometriosis Paid Clinical Study at Totally Free StuffTotally Free Stuff
With Acurian Health - Uterine Fibroids and Endometriosis allows women who suffer from Uterine Fibroids or Endometriosis to see if they qualify to participate in a study and receive up to $500, plus no
Had hysteroscopy and laparoscopy for endometriosis. Left ovary fused to the bowel. Will there be any problem in the future? -...Had hysteroscopy and laparoscopy for endometriosis. Left ovary fused to the bowel. Will there be any problem in the future? -...
Question - Had hysteroscopy and laparoscopy for endometriosis. Left ovary fused to the bowel. Will there be any problem in the future?. Ask a Doctor about diagnosis, treatment and medication for Endometriosis, Ask a Gastroenterologist
Integrin beta 3Integrin beta 3
DanazolDanazol
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EndometriosisEndometriumPelvic PainPeritoneal DiseasesOvarian DiseasesDysmenorrheaInfertility, FemaleAscitic FluidUterine DiseasesDanazolRectal DiseasesLaparoscopyDyspareuniaMenstrual CycleUreteral DiseasesSigmoid DiseasesPapio anubisVaginal DiseasesStromal CellsOvarian CystsPelvisMenstruationDigestive System DiseasesUrinary Bladder DiseasesMenstruation DisturbancesCase-Control StudiesChoristomaCA-125 AntigenLeuprolideGynecologic Surgical ProceduresPeritoneumThoracic DiseasesDouglas' PouchUmbilicusDiagnostic Techniques, Obstetrical and GynecologicalInfertilityAbdominal WallUterusPapioEncyclopedias as TopicInfertility, MaleCoagulation Protein DisordersMenopauseMenarcheEstrogensFertilityGynecologyObstetricsFallopian TubesFallopian Tube NeoplasmsVaginaRectum
Endometriosis and infertility - WikipediaEndometriosis and infertility - Wikipedia
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AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
EndometriosisEndometriumPelvic PainPeritoneal DiseasesOvarian DiseasesDysmenorrheaInfertility, FemaleAscitic FluidUterine DiseasesDanazolRectal DiseasesLaparoscopyDyspareuniaMenstrual CycleUreteral DiseasesSigmoid DiseasesPapio anubisVaginal DiseasesStromal CellsOvarian CystsPelvisMenstruationDigestive System DiseasesUrinary Bladder DiseasesMenstruation DisturbancesCase-Control StudiesChoristomaCA-125 AntigenLeuprolideGynecologic Surgical ProceduresPeritoneumThoracic DiseasesDouglas' PouchUmbilicusDiagnostic Techniques, Obstetrical and GynecologicalInfertilityAbdominal WallUterusPapioEncyclopedias as TopicInfertility, MaleCoagulation Protein DisordersMenopauseMenarcheEstrogensFertilityGynecologyObstetricsFallopian TubesFallopian Tube NeoplasmsVaginaRectum
InfertilityEndometriumLaparoscopySymptoms of endometriosisLesionsTissueFertilityUterusSurgicalPelvisTreatmentsLaparoscopic surgeryPainfulHormonalPeritoneal endometriosisMildBowelEndometrial cellsTreat endometriosisSevere endometriosisReproductiveRisk of endometriosisDiagnosis of endometriosisPregnancySurgeryPelvic inflammMenstruationPrevalencePainTreatmentPregnantPatientsModerateGeneticOrgansSeverityInflammatory
Infertility12
Endometrium5
Laparoscopy3
Symptoms of endometriosis4
Lesions2
Tissue5
  • Endometriosis is a painful condition that affects women during their reproductive years and is caused by the growth of the tissue lining the uterus in other parts of the abdomen outside of the uterus, such as the ovaries. (reuters.com)
  • Endometriosis is a condition resulting from the appearance of endometrial tissue outside the uterus. (prezi.com)
  • Endometriosis is defined as the presence of endometrial-like endometrial cells, glands and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. (frontiersin.org)
  • Macrophages are so crucial to our immune system tissue function and we need to know more about their roles, so this research goes some way in defining how macrophages are different in endometriosis. (warwick.ac.uk)
  • Endometriosis can cause painful bowel movements - and also blood in stool - because the endometrial tissue may get implanted on the inner sides of the intestines, leading to bowel obstructions. (foodnhealth.org)
Fertility8
  • In-vitro fertilization (IVF) procedures are effective in improving fertility in many women with endometriosis. (wikipedia.org)
  • The purpose of endometriosis surgery is to obtain good long-term outcomes regarding pain relief, recurrence rates, and fertility without compromising the function of involved organs. (frontiersin.org)
  • If you have severe pain or fertility problems from endometriosis , and medicines or hormone therapy haven't helped, surgery may provide a solution. (premierhealth.com)
  • Pregnancy in fact is actually a great treatment for endometriosis.so if fertility is on the horizon just getting pregnant may do a great job of suppressing the endometriosis from growing further and controlling the patient's pain not only during the pregnancy but also for many months afterwards. (premierhealth.com)
  • Besides affecting fertility , endometriosis can result in painful menses (dysmenorrhea) and painful intercourse (dyspareunia). (princetonivf.com)
  • The most commonly used classification of disease, the revised American Fertility Society (rAFS) system to grade endometriosis into different stages based on disease severity (I to IV), has been questioned as it does not correlate well with underlying symptoms, posing issues in diagnosis and choice of treatment. (ox.ac.uk)
  • If you have endometriosis and also are worried concerning developing a pregnancy, take heart: One-third of ladies with endometriosis will easily get pregnant with no artificial fertility therapy in any way. (wellinghomeopathy.com)
  • Research results differ on the performance of therapy alternatives for this leading source of inability to conceive, yet Adamson states at the very least 40 to HALF of ladies with endometriosis that are recommended common fertility medicines will certainly conceive, as will certainly an extra 40 percent of ladies which go through several patterns of artificial insemination fertilization (IVF). (wellinghomeopathy.com)
Uterus2
Surgical6
  • One study has shown that surgical treatment of endometriosis approximately doubles the fecundity (pregnancy rate). (wikipedia.org)
  • Multiple minimally invasive surgical approaches and techniques are available for treatment of endometriosis and often require the expertise of both gynecologist and general surgeon or urologist. (frontiersin.org)
  • In this Research Topic we welcome Original Research, Methods, Review, Mini Review, Perspective, Case Report, General Commentary, Opinion and Clinical Study Protocol that help in the understanding of and the discussion on the above mentioned surgical approaches for endometriosis. (frontiersin.org)
  • The objective of this study is to compare the effectiveness of two surgical techniques (suturing versus flowering of Bruhat) after fimbrioplasty for treatment of distal tubal pathology in infertile women with endometriosis. (elsevier.com)
  • Surgical treatment to eliminate endometriosis sores additionally has actually been confirmed effective in 30 to 80 percent of situations, relying on the seriousness of the illness, based on Adamson. (wellinghomeopathy.com)
  • Surgical procedure likewise has actually been recognized to periodically boost endometriosis signs and symptoms and also inability to conceive, interrupting blood circulation to the ovaries and also producing mark cells that is even worse compared to the initial endometrial development. (wellinghomeopathy.com)
Pelvis1
  • If no anomaly is revealed by echography, during pre-operative examination, or through laparoscopic examination of the small pelvis, isolated endometriosis that affects e.g. the sciatic nerve may be considered as a possible cause of the symptoms. (hirslanden.ch)
Treatments3
Laparoscopic surgery1
Painful3
Hormonal1
  • Its etiopathogenesis of endometriosis still remains controversial: immune, hormonal, genetic, and epigenetic factors may be all involved, and several theories have been proposed to explain it. (frontiersin.org)
Peritoneal endometriosis1
  • Three main clinical presentations have been described: peritoneal endometriosis, endometriotic ovarian cysts (i.e., endometriomas), and deeply infiltrating endometriosis (DIE) .The latter is considered the most aggressive presentation of endometriosis, penetrating more than 5mm in affected tissues and affecting approximately 20% of all women with the disease. (frontiersin.org)
Mild8
  • Some women with endometriosis may have mild symptoms only, while others have moderate to severe symptoms. (thehealthology.com)
  • For instance, a woman may have mild endometriosis only but may experience a great deal of pain. (thehealthology.com)
  • Because of the mild diuretic properties of chamomile tea, it is usually recommended by traditional healers for women with endometriosis. (thehealthology.com)
  • Using two independent European genome-wide association (GWA) datasets and top-level classification of the endometriosis cases based on rAFS [minimal or mild (Stage A) and moderate-to-severe (Stage B) disease], we previously showed that Stage B endometriosis has greater contribution of common genetic variation to its aetiology than Stage A disease. (ox.ac.uk)
  • Herein, we extend our previous analysis to four endometriosis stages [minimal (Stage I), mild (Stage II), moderate (Stage III) and severe (Stage IV) disease] based on the rAFS classification system and compared the genetic burden across stages. (ox.ac.uk)
  • Mild and moderate endometriosis appeared genetically similar, making it difficult to tease them apart. (ox.ac.uk)
  • Consistent with our previous reports, moderate and severe endometriosis showed greater genetic burden than minimal or mild disease. (ox.ac.uk)
  • Depending on the extent of the abnormal growth of endometrial cells, the cases of Endometriosis are categorized as 'mild,' 'moderate,' or 'severe. (foodnhealth.org)
Bowel4
Endometrial cells3
  • For factors physicians do not completely comprehend, ladies with endometriosis create uterine (endometrial) cells around the procreative body organs, beyond where it is typically located in the womb. (wellinghomeopathy.com)
  • As a result of the abnormal growth of endometrial cells in women suffering from Endometriosis, an inflammatory process is triggered, because of which these cells start reproducing themselves and can spread out to other parts of the body as well. (foodnhealth.org)
  • Moreover, as the abnormal growth of the endometrial cells gets bigger, the women suffering from Endometriosis start getting much heavier periods. (foodnhealth.org)
Treat endometriosis2
  • We hope that in the future we can learn exactly how disease-modified macrophages in endometriosis promote disease and how we can target them in order to treat endometriosis. (warwick.ac.uk)
  • If they're trying to get pregnant surgery to treat endometriosis can really optimize their chances of conceiving. (premierhealth.com)
Severe endometriosis1
Reproductive2
Risk of endometriosis5
  • Genetic or heredity factors (Some studies put the risk of endometriosis as 10-fold higher among women who have a first degree relative with endometriosis, but at least one study has found the risk to be closer to 2 times as high. (umm.edu)
  • and (4) determine whether the risk of endometriosis resulting from organochlorine pesticide or PCB exposure differs among women with differing levels of other exposures affecting estrogen levels. (epa.gov)
  • This study is an ancillary investigation to Women's Risk of Endometriosis (WREN), a case-control study funded by the National Institute of Child Health and Human Development. (epa.gov)
  • Results Duration of total and exclusive breast feeding was significantly associated with decreased risk of endometriosis. (elsevier.com)
  • This association was partially, but not fully, influenced by postpartum amenorrhea, suggesting that breast feeding could influence the risk of endometriosis both through amenorrhea and other mechanisms. (elsevier.com)
Diagnosis of endometriosis1
Pregnancy6
Surgery5
  • No difference has been found between surgery (cystectomy or aspiration) versus expectant management, or between ablation versus cystectomy, prior to IVF in women with endometriosis. (wikipedia.org)
  • Currently, endometriosis can only be diagnosed via surgery and we want to reduce the diagnostic delay by developing a way that GPs (general practitioners) can better identify the markers of endometriosis. (reuters.com)
  • elective salpingectomy/tubal ligation without endometriosis for controls.If insufficient numbers of subjects undergoing sterilization are available for recruitment, we will also include subjects undergoing surgery for abnormal uterine bleeding as controls. (mayo.edu)
  • Have not been on hormone therapy for endometriosis or contraception in the past 4 weeks before surgery. (mayo.edu)
  • There is no known cure for endometriosis, but there are medications as well as surgery that can help control the symptoms. (thehealthology.com)
Pelvic inflamm1
Menstruation4
Prevalence1
  • The goal of this project is to assess the prevalence of exposure to organic pollutants in endometriosis cases and controls in a large health maintenance organization in western Washington State and to examine the interactions of these exposures with polymorphisms in genes involved in estrogen metabolism. (epa.gov)
Pain6
  • A key cause for the pelvic pain experienced by women with endometriosis has been uncovered, potentially opening new opportunities for pain relief for the condition. (warwick.ac.uk)
  • For this research the team focused on the role of macrophages, a type of white blood cell found in our immune system, in contributing to the pain caused by endometriosis. (warwick.ac.uk)
  • Applying this onto nerve cells grown in culture, they found that this encouraged the nerves to grow and also activated them, demonstrating that production of IGF-1 by macrophages plays an important role in generating pain in endometriosis. (warwick.ac.uk)
  • Previous studies have shown that macrophages can be involved in other types of chronic pain, but this is the first time that it has been shown to be linked to endometriosis. (warwick.ac.uk)
  • Extremely heavy periods and clots in period blood, along with excessive pain, are generally another important symptom of Endometriosis. (foodnhealth.org)
  • One of the most obvious and typical signs of Endometriosis is pelvic pain which becomes quite unbearable during periods. (foodnhealth.org)
Treatment5
  • As a result, patients affected by endometriosis often receive medication as sole treatment. (hirslanden.ch)
  • Patients suffering from nerve endometriosis often undergo pharmacological treatment lasting many years. (hirslanden.ch)
  • If we can learn about the role of macrophages in endometriosis then we can distinguish them from healthy macrophages and target treatment to them. (warwick.ac.uk)
  • Just like what's mentioned before, endometriosis has no known treatment to date, although certain drugs may be administered and undergoing the knife may be warranted to have the symptoms controlled. (thehealthology.com)
  • Overall, our results provide new insights into the genetic architecture of endometriosis and further investigation in larger samples may help to understand better the aetiology of varying degrees of endometriosis, enabling improved diagnostic and treatment modalities. (ox.ac.uk)
Pregnant1
  • Given the chronic and incurable nature of endometriosis, breast feeding should be further investigated as an important modifiable behavior to mitigate risk for pregnant women. (elsevier.com)
Patients5
Moderate1
  • Several professionals think IVF is practical for clients with serious condition, specifically ladies with lots of attachments, yet there are no clear verdicts pertaining to IVF for moderate endometriosis. (wellinghomeopathy.com)
Genetic1
  • Genetic burden associated with varying degrees of disease severity in endometriosis. (ox.ac.uk)
Organs1
Severity1
Inflammatory3
  • Consuming turmeric tea on a regular basis is beneficial for a woman with endometriosis because of its strong anti-inflammatory properties which is courtesy of curcumin in the well-known spice. (thehealthology.com)
  • Other than turmeric tea, ginger tea is also an excellent home remedy for endometriosis because it possesses impressive anti-inflammatory properties, too. (thehealthology.com)
  • Moreover, it provides further insight into the link between HPA axis dysregulation, emotional responses, and the high comorbidity between endometriosis and other inflammatory conditions. (ox.ac.uk)
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