Endometriosis
Endometrium
Pelvic Pain
Danazol
Rectal Diseases
Laparoscopy
Dyspareunia
Menstrual Cycle
Sigmoid Diseases
Papio anubis
Stromal Cells
Pelvis
Menstruation
Digestive System Diseases
Case-Control Studies
CA-125 Antigen
Leuprolide
Peritoneum
Umbilicus
Diagnostic Techniques, Obstetrical and Gynecological
Infertility
Abdominal Wall
Uterus
Papio
Molecular and cellular aspects of endometrial receptivity. (1/1690)
Endocrine and paracrine controls regulate the endometrium during the luteal phase of the cycle to permit implantation. Part of this differentiation process is the production of a specific secretion which fills the intrauterine cavity and glandular lumen. Its molecular composition originates from the gland secretion, from transudations from stroma, from the endometrial blood vessels, and last, but not least, from cellular components of apoptotic and exfoliated cells. We have studied the secretions of all phases during the menstrual cycle using patterns evaluated by SDS-PAGE, by laser densitometry or Western blots. Uterine secretion electrophoresis (USE) permits detailed analyses of the intrauterine micromilieu and allows clinical assessment of the receptive stage of endometrium during the luteal phase. Several individual protein bands have been defined as characteristic markers for such receptive pattern. We have isolated and identified the molecular structure of several of these proteins, e.g. histones, cyclophilin, transthyretin, haptoglobin and uteroglobin. Investigations on the endocrine regulation of these proteins, were carried out on the uterine secretions of patients treated with progesterone antagonists (mifepristone and onapristone). The results demonstrate how progesterone-dependent components produce a receptive pattern, which can serve as a useful and precise marker in the clinical diagnosis of the luteal phase. Essential progesterone-dependent components differentiating during the luteal phase may provide new targets for contraceptive interventions by preventing the physiological changes typical of receptivity. (+info)Decreased apoptosis and sensitivity to macrophage mediated cytolysis of endometrial cells in endometriosis. (2/1690)
Ectopic dissemination of endometrial cells and their subsequent implantation are the mechanisms involved in the development of endometriosis. While the process of dissemination appears to be a phenomenon common to all women, it is unknown what facilitates or prevents ectopic implantation of misplaced endometrial cells. Prior studies by our group and others suggest that cell-mediated immunity in patients with endometriosis is decreased. The present studies evaluated (i) peripheral blood monocyte (PBM) and peritoneal macrophage (PM) mediated cytolysis of autologous eutopic and ectopic endometrial cells and (ii) programmed cell death (apoptosis) in the eutopic and ectopic endometrium. PBM-mediated cytolysis was (mean+/-SD) 23.1+/-13% for the eutopic and 7.8+/-% for the ectopic endometrium (P < 0.004), while the corresponding percentages for PM-mediated cytolysis were 5.4+/-7 and 0.3+/-1 respectively (P < 0.04). This indicates that PBM are much more effective than PM in inducing cytolysis of both eutopic and ectopic endometrium and that ectopic endometrial cells are significantly more resistant to both PBM- and PM-mediated cytolysis. The apoptosis was significantly decreased in the eutopic endometrium of women with endometriosis as compared to fertile controls (0.375+/-0.17 versus 1.57+/-0.3, P < 0.0001). Furthermore, in matched samples apoptosis was significantly lower in the ectopic (0.149+/-0.075) than eutopic (0.375+/-0.17) endometrium (P < 0.001). We conclude from these studies that the decrease in the capacity of monocytes to mediate cytolysis of the misplaced endometrial cells in the peritoneal locations and an increased resistance of these cells to apoptosis are fundamental to the aetiology and/or pathophysiology of endometriosis. (+info)Phenotypic and functional studies of leukocytes in human endometrium and endometriosis. (3/1690)
The aetiology of endometriosis, a common and disabling disorder, is presently unknown, although immune dysfunction could allow ectopic endometrial fragments to survive outside the uterine cavity. These studies investigate the relationship between leukocyte populations, steroid hormone receptor expression, proliferative activity, bcl-2 expression and apoptosis in eutopic and ectopic endometrium from women with endometriosis or adenomyosis at different phases of the menstrual cycle. Significantly increased oestrogen receptor expression, bcl-2 expression and numbers of CD8+ leukocytes were found in ectopic compared with eutopic endometrium in endometriosis, and CD56+ endometrial granulated lymphocytes (eGLs) were significantly reduced in ectopic endometrium. Apoptotic cells were rarely found in control and subject endometria. In contrast with endometriosis, adenomyotic lesions showed identical steroid hormone receptor expression, proliferative activity, bcl-2 expression and leukocyte subpopulations to eutopic endometrium, indicating different aetiologies for these disorders. The unusual CD56+ CD16- eGLs present in large numbers in late secretory phase eutopic endometrium were highly purified (>98%) by immunomagnetic separation. Except for a negligible cytotoxic activity of eGLs from early proliferative samples, cytotoxic activity of eGLs from non-pregnant endometrium during the menstrual cycle was comparable with those in peripheral blood, predominantly CD56+ CD16+ natural killer cells. eGLs from non-pregnant endometrium and early pregnancy showed a variable proliferative response to 5 and 100 U/ml interleukin-2 over 48-h and 120-h time courses. eGLs are evidently functionally important in the eutopic endometrium. Their absence in endometriotic lesions together with increased CD+8 T-cell numbers and increased oestrogen receptor and bcl-2 expression may have significant effects on the development and progression of endometriosis. (+info)Expression pattern of integrin adhesion molecules in endometriosis and human endometrium. (4/1690)
Integrins are cell adhesion molecules that undergo cell-specific dynamic changes during the normal menstrual cycle in the human endometrium. Here, using immunohistochemistry, we have investigated the expression pattern of the integrins alphav, alpha2beta1, alpha3beta1, alpha3, alpha6, beta1, beta2 and beta3 in the human ectopic endometrium of 30 patients and in nine cases in the corresponding eutopic endometrium. The biopsies were obtained during the early or late follicular phase (25 cases), during the corpus luteum phase (four cases) and in one case after 6 months' treatment with a gonadotrophin releasing hormone (GnRH) agonist. The integrin expression was independent of the ovarian steroid situation at the time of biopsy. The integrin alpha6 was expressed in all endometriotic and endometrium samples. The integrin alpha3 was absent in all endometrium tissues of patients with endometriosis. However, the corresponding endometriotic lesions re-expressed this adhesion molecule in 15 cases. No change in integrin beta3 expression pattern could be demonstrated in either endometriotic lesions or endometrium samples, regardless of the menstrual cycle phase. A correlation between serum oestradiol and progesterone concentrations and the expression of the investigated integrins was not observed, thus indicating that these two hormones play a minor role in the regulation of the cell adhesion molecules examined. Our investigation suggests that endometriosis is a dedifferentiated disease as it expressed different integrins in comparison with the eutopic endometrium, and independently of the hormonal situation. The ability of endometriotic tissues to express integrins may explain the high recurrence rates in patients with endometriosis, as these samples retain their adhesion potency after retrograde menstruation and are thus able to establish cell-cell and cell-matrix interactions with the surrounding peritoneum. (+info)Paracrine changes in the peritoneal environment of women with endometriosis. (5/1690)
During the past decade, macrophage-derived substances such as prostanoids, cytokines, growth factors and angiogenic factors have been detected in the peritoneal fluid of women with endometriosis. In particular, growth-promoting and angiogenic factors are considered to be substantially involved in the pathogenesis of endometriosis. In this study, vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF-beta) and intercellular adhesion molecule 1 (ICAM-1), substances recently detected in the peritoneal fluid of women with endometriosis, were assessed with regard to their concentrations in different stages of endometriosis and changes of the peritoneal paracrine activity after medical treatment with a gonadotrophin releasing hormone agonist (GnRHa). Peritoneal fluid was obtained from patients with endometriosis during laparoscopy before and after a 4-month treatment with a GnRHa. VEGF, TGF-beta and ICAM-1 could be detected in all women presenting with various stages of active endometriosis. After GnRHa therapy, all patients showed significant decreases in mean concentrations of VEGF (194+/-77 pg/ml), TGF-beta (902+/-273 pg/ml) and ICAM-1 (157+/-52 ng/ml). Patients with stage III and IV endometriosis (according to the rAFS score) had much higher concentrations of VEGF and TGF-beta before treatment compared with those patients with mild endometriosis (rAFS stages I and II). The most striking decrease in concentration was for TGF-beta, from 902 pg/ml before to 273 pg/ml after therapy. These results indicate an important role for paracrine activity in the establishment and maintenance of endometriosis. Indeed, treatment with a GnRHa may reduce paracrine activity in the peritoneal cavity via hypo-oestrogenism and provide proof of successful therapy. (+info)Tracing cellular and molecular mechanisms involved in endometriosis. (6/1690)
The aetiology and pathogenesis of endometriosis, defined as the presence of endometrium-like tissue outside the uterine cavity, is largely unknown. In this paper we present and discuss possibilities to study the putative pathogenic properties of endometriotic cells in vitro. The current focus of our investigations is on the invasive phenotype of the disease, assuming that this might contribute to the pathogenesis of endometriosis. So far, we have shown that: (i) cytokeratin-positive and E-cadherin-negative endometriotic cells have an invasive phenotype in a collagen invasion assay in vitro similar to metastatic carcinoma cells; (ii) the invasiveness of endometriotic but not of eutopic endometrial cells can be stimulated by a heat-stable protein present in peritoneal fluid; and (iii) the endometriotic cell line EEC145T, which we established, may be a useful tool for the identification of gene products which are, positively or negatively, invasion-related. Finally, our studies suggest that the invasive phenotype in endometriosis shares aspects with tumour metastasis, but might also have unique mechanisms. (+info)Extracellular matrix remodelling in the endometrium and its possible relevance to the pathogenesis of endometriosis. (7/1690)
Essential features of endometrial physiology involve the extracellular matrix (ECM). In the pathogenesis of endometriosis, interactions of endometriosis cells with ECM can be postulated. Two systems of secreted proteases in the endometrium, the plasmin(ogen) activator/inhibitor and the matrix metalloproteinases and their inhibitors were examined in cell cultures of uterine endometrial cells from women with and without endometriosis. Soluble urokinase receptor secretion is increased, and mRNA transcription of tissue inhibitor of metalloproteinases-2 (TIMP-2) is upregulated by progestin in endometriosis. These findings are compatible with an altered ECM turnover in the endometrium of these patients that may explain a higher invasive potential of retrogradely menstruated endometrial fragments. (+info)Angiogenesis: a new theory for endometriosis. (8/1690)
Excessive endometrial angiogenesis is proposed as an important mechanism in the pathogenesis of endometriosis. Evidence is reviewed for the hypothesis that the endometrium of women with endometriosis has an increased capacity to proliferate, implant and grow in the peritoneal cavity. Data is summarized indicating that the endometrium of patients with endometriosis shows enhanced endothelial cell proliferation. Results are also reviewed indicating that the cell adhesion molecule integrin alphavbeta3 is expressed in more blood vessels in the endometrium of women with endometriosis when compared with normal women. Taken together, these results provide evidence for increased endometrial angiogenesis in women with endometriosis when compared with normal subjects. Endometriosis is one of the family of angiogenic diseases. Other angiogenic diseases include solid tumours, rheumatoid arthritis, psoriasis and diabetic retanopathy. Excessive endometrial angiogenesis suggests novel new medical treatments for endometriosis aimed at the inhibition of angiogenesis. (+info)Endometriosis is a medical condition in which the tissue that normally lines the inside of the uterus (endometrium) grows outside of the uterus, on other organs in the pelvic cavity, such as the ovaries, fallopian tubes, and the lining of the pelvis. This tissue can also grow on the surface of the bowel, bladder, or other abdominal organs. Endometriosis can cause a range of symptoms, including pelvic pain, heavy menstrual bleeding, pain during sex, and infertility. The severity of symptoms can vary widely from person to person, and some people with endometriosis may not experience any symptoms at all. The exact cause of endometriosis is not known, but it is thought to be related to the retrograde menstruation, which is the backward flow of menstrual blood through the fallopian tubes and into the pelvic cavity. This can cause the endometrial tissue to implant and grow in other areas of the body. Diagnosis of endometriosis typically involves a combination of physical examination, medical history, and imaging tests such as ultrasound, MRI, or laparoscopy. Treatment options for endometriosis include pain management, hormonal therapy, and surgery to remove the endometrial tissue.
Pelvic pain is a common condition that affects people of all ages and genders. It is defined as any pain or discomfort felt in the pelvic region, which includes the bones, muscles, ligaments, and organs in the area around the pelvis. Pelvic pain can be acute or chronic, and it can be caused by a variety of factors, including infections, injuries, hormonal changes, and certain medical conditions such as endometriosis, pelvic inflammatory disease, and ovarian cysts. It can also be caused by stress, anxiety, and other psychological factors. The severity and duration of pelvic pain can vary widely, and it can affect a person's ability to perform daily activities and engage in sexual activity. Treatment for pelvic pain depends on the underlying cause and may include medications, physical therapy, surgery, or other interventions.
Peritoneal diseases refer to a group of medical conditions that affect the peritoneum, which is the thin, flexible membrane that lines the abdominal cavity and covers the organs within it. The peritoneum plays an important role in the functioning of the digestive system and the absorption of nutrients from digested food. Peritoneal diseases can be classified into two main categories: primary and secondary. Primary peritoneal diseases are those that arise from the peritoneum itself, such as peritoneal mesothelioma (a type of cancer that develops from the mesothelial cells lining the peritoneum) and peritoneal inflammation (such as peritonitis, which is caused by an infection or injury to the peritoneum). Secondary peritoneal diseases, on the other hand, are those that occur as a result of an underlying condition, such as cancer (e.g., ovarian cancer, stomach cancer, or colon cancer) that has spread to the peritoneum, or kidney failure that leads to the accumulation of fluid in the peritoneal cavity. Symptoms of peritoneal diseases can vary depending on the specific condition, but may include abdominal pain, bloating, nausea, vomiting, weight loss, and fever. Treatment options for peritoneal diseases depend on the underlying cause and may include surgery, chemotherapy, radiation therapy, or supportive care to manage symptoms and improve quality of life.
Ovarian diseases refer to any medical conditions that affect the ovaries, which are the female reproductive organs responsible for producing eggs and hormones such as estrogen and progesterone. These diseases can affect women of all ages and can range from benign to life-threatening. Some common ovarian diseases include: 1. Polycystic ovary syndrome (PCOS): A hormonal disorder that affects the ovaries and can cause irregular periods, infertility, and other symptoms. 2. Ovarian cancer: A type of cancer that starts in the ovaries and can spread to other parts of the body. 3. Endometriosis: A condition in which tissue that normally lines the inside of the uterus grows outside of it, often on the ovaries. 4. Ovarian cysts: Fluid-filled sacs that can develop on the ovaries and may be benign or cancerous. 5. Ovarian torsion: A condition in which the ovary twists on its stalk, cutting off blood flow and causing pain and other symptoms. 6. Ovarian hyperstimulation syndrome (OHSS): A rare but serious condition that can occur in women undergoing fertility treatments, such as in vitro fertilization (IVF), in which the ovaries become overly stimulated and produce too many eggs. Treatment for ovarian diseases depends on the specific condition and its severity. It may include medications, surgery, or other interventions. Early detection and treatment are important for improving outcomes and preventing complications.
Dysmenorrhea is a medical condition characterized by painful menstrual periods. It is also known as menstrual cramps or period pain. Dysmenorrhea can range from mild discomfort to severe pain that can interfere with daily activities. The pain is usually felt in the lower abdomen and can sometimes radiate to the back and legs. Dysmenorrhea is a common condition that affects many women of reproductive age, and it can be caused by a variety of factors, including hormonal changes, inflammation, and muscle contractions. Treatment for dysmenorrhea may include over-the-counter pain medication, heat therapy, and lifestyle changes such as exercise and stress management. In some cases, medical treatment may be necessary to address the underlying cause of the pain.
Infertility, female refers to the inability of a woman to conceive a child after a year of regular, unprotected sexual intercourse. This condition can be caused by a variety of factors, including hormonal imbalances, structural abnormalities in the reproductive organs, infections, and lifestyle factors such as smoking, excessive alcohol consumption, and poor nutrition. Infertility can also be caused by age, with fertility declining naturally as a woman gets older. Treatment options for female infertility may include medications to stimulate ovulation, surgery to correct structural abnormalities, assisted reproductive technologies such as in vitro fertilization (IVF), or the use of donor eggs or embryos.
Ascitic fluid is a clear or yellowish fluid that accumulates in the abdominal cavity, specifically in the peritoneal cavity, which is the space that surrounds the abdominal organs. It is a common complication of various medical conditions, including liver cirrhosis, heart failure, cancer, and infections. The normal amount of ascitic fluid in the abdominal cavity is usually less than 500 milliliters. However, when the amount of fluid exceeds 1 liter, it is considered an accumulation of ascitic fluid, which can cause symptoms such as abdominal pain, bloating, and shortness of breath. The diagnosis of ascites is usually made through physical examination, abdominal imaging, and laboratory tests. Treatment options for ascites depend on the underlying cause and may include medications, dietary changes, lifestyle modifications, and in severe cases, surgical intervention.
Uterine diseases refer to medical conditions that affect the uterus, which is the female reproductive organ responsible for carrying and nourishing a developing fetus during pregnancy. These diseases can be classified into several categories, including: 1. Infections: Infections of the uterus can be caused by bacteria, viruses, or fungi. Examples include bacterial vaginosis, chlamydia, gonorrhea, and pelvic inflammatory disease. 2. Endometriosis: Endometriosis is a condition in which the tissue that normally lines the uterus grows outside of it, causing pain and inflammation. 3. Fibroids: Fibroids are non-cancerous growths that develop in the uterus. They can cause heavy bleeding, pain, and other symptoms. 4. Polyps: Polyps are small growths that develop on the lining of the uterus. They can cause bleeding and other symptoms. 5. Cancer: Uterine cancer, also known as endometrial cancer, is a rare but serious condition that develops in the lining of the uterus. 6. Miscarriage: Miscarriage is the loss of a pregnancy before the 20th week of gestation. It can be caused by a variety of factors, including uterine abnormalities. 7. Adenomyosis: Adenomyosis is a condition in which the tissue that normally lines the uterus grows into the muscle wall of the uterus, causing pain and heavy bleeding. 8. Uterine prolapse: Uterine prolapse is a condition in which the uterus drops down into the vagina, causing discomfort and other symptoms. Treatment for uterine diseases depends on the specific condition and its severity. It may include medications, surgery, or other interventions.
Danazol is a synthetic androgenic steroid medication that is used to treat a variety of conditions, including endometriosis, fibrocystic breast disease, and hereditary angioedema. It works by reducing the production of estrogen in the body, which can help to shrink tumors and reduce inflammation. Danazol is typically taken orally in tablet form and is usually prescribed for short-term use, although it can be used for longer periods of time in some cases. It is important to note that Danazol can have side effects, including mood changes, weight gain, and liver problems, and should only be taken under the supervision of a healthcare provider.
Rectal diseases refer to medical conditions that affect the rectum, which is the final part of the large intestine. The rectum is responsible for storing feces until they are eliminated from the body through the anus. Rectal diseases can be acute or chronic and can range from minor to severe. Some common rectal diseases include: 1. Hemorrhoids: Swollen veins in the rectum or anus that can cause pain, itching, and bleeding. 2. Anal fissures: Tears in the lining of the anus that can cause pain and bleeding during bowel movements. 3. Fistulas: Abnormal connections between the rectum and other organs or tissues, such as the skin or vagina. 4. Polyps: Non-cancerous growths in the rectum that can cause bleeding or blockage. 5. Inflammatory bowel disease (IBD): Chronic conditions that cause inflammation in the rectum and other parts of the digestive tract, including Crohn's disease and ulcerative colitis. 6. Rectal cancer: A type of cancer that starts in the rectum and can spread to other parts of the body. Rectal diseases can be diagnosed through a physical examination, medical imaging tests, and other diagnostic procedures. Treatment options depend on the specific disease and may include medications, surgery, or other therapies.
Dyspareunia is a medical term used to describe persistent or recurring pain during sexual intercourse. It can affect both men and women and can be caused by a variety of factors, including physical conditions, psychological factors, or a combination of both. In women, dyspareunia can be caused by conditions such as vaginal dryness, vaginal atrophy, pelvic inflammatory disease, endometriosis, or vulvar vestibulitis syndrome. In men, it can be caused by conditions such as erectile dysfunction, premature ejaculation, or Peyronie's disease. Dyspareunia can also be caused by psychological factors, such as anxiety, depression, or past traumatic experiences. It can also be a symptom of underlying medical conditions, such as fibromyalgia or chronic fatigue syndrome. Treatment for dyspareunia depends on the underlying cause. It may involve medications, therapy, or lifestyle changes. It is important to seek medical attention if dyspareunia is persistent or severe, as it can have a significant impact on a person's quality of life and their ability to have satisfying sexual relationships.
Ureteral diseases refer to medical conditions that affect the ureters, which are the tubes that carry urine from the kidneys to the bladder. The ureters are approximately 10 inches long and are located in the pelvis. Ureteral diseases can be acute or chronic and can range from mild to severe. Some common ureteral diseases include: 1. Ureteral stones: Small, hard deposits that form in the ureters and can cause pain, blood in the urine, and difficulty urinating. 2. Ureteral strictures: Narrowing of the ureter that can occur due to injury, infection, or other medical conditions. 3. Ureteral tumors: Benign or malignant growths that can occur in the ureter and cause symptoms such as blood in the urine, pain, and difficulty urinating. 4. Ureteral infections: Infections that can occur in the ureter and cause symptoms such as fever, chills, and pain. 5. Ureteral obstructions: Blockages that can occur in the ureter and prevent urine from flowing normally. 6. Ureteral diverticula: Outpouchings of the ureter that can occur due to weakened or damaged walls of the ureter. Treatment for ureteral diseases depends on the specific condition and may include medications, surgery, or other medical procedures. It is important to seek medical attention if you experience symptoms of a ureteral disease, as prompt treatment can help prevent complications and improve outcomes.
In the medical field, "sigmoid diseases" refers to a group of conditions that affect the sigmoid colon, which is the lower part of the large intestine. The sigmoid colon is the final section of the colon before the rectum and is responsible for absorbing water and electrolytes from the remaining undigested food matter. Examples of sigmoid diseases include: 1. Sigmoid volvulus: A condition in which the sigmoid colon twists on itself, cutting off blood flow to the affected area. 2. Sigmoid diverticulitis: A condition in which small pouches in the sigmoid colon become inflamed and infected. 3. Sigmoid polyps: Non-cancerous growths on the lining of the sigmoid colon. 4. Sigmoid cancer: Cancerous growths on the lining of the sigmoid colon. 5. Sigmoiditis: Inflammation of the sigmoid colon. These conditions can cause a range of symptoms, including abdominal pain, bloating, constipation, diarrhea, and rectal bleeding. Treatment for sigmoid diseases depends on the specific condition and may include medications, surgery, or other interventions.
Vaginal diseases refer to any medical conditions that affect the vagina, including infections, inflammations, and structural abnormalities. These conditions can cause a range of symptoms, such as itching, burning, discharge, pain, and bleeding. Some common vaginal diseases include bacterial vaginosis, yeast infections, trichomoniasis, vaginitis, and vaginal atrophy. These conditions can be caused by various factors, such as hormonal changes, poor hygiene, sexual activity, and certain medications. Treatment for vaginal diseases depends on the specific condition and its severity. It may involve the use of antifungal, antibiotic, or antiviral medications, as well as lifestyle changes and hygiene practices. In some cases, surgery may be necessary to correct structural abnormalities or remove growths. It is important for women to be aware of the signs and symptoms of vaginal diseases and to seek medical attention if they experience any concerning symptoms. Early detection and treatment can help prevent complications and improve outcomes.
Ovarian cysts are fluid-filled sacs that develop on the ovaries, which are the female reproductive organs responsible for producing eggs. These cysts are a common occurrence in women of all ages, but are most commonly found in women of reproductive age. There are two types of ovarian cysts: functional and non-functional. Functional cysts are caused by hormonal changes in the body and usually resolve on their own within a few months. Non-functional cysts, on the other hand, are not caused by hormones and may require medical intervention. Symptoms of ovarian cysts may include abdominal pain, bloating, and discomfort during sexual intercourse. In some cases, ovarian cysts may be asymptomatic and discovered during a routine pelvic exam. Diagnosis of ovarian cysts typically involves imaging tests such as ultrasound or MRI. Treatment options depend on the size and type of cyst, as well as the patient's overall health. Small cysts may be monitored with regular imaging tests, while larger cysts or cysts that cause symptoms may require surgical removal.
Digestive system diseases refer to a group of medical conditions that affect the organs and structures involved in the digestion and absorption of food. These diseases can affect any part of the digestive system, including the mouth, esophagus, stomach, small intestine, large intestine, rectum, anus, liver, gallbladder, pancreas, and bile ducts. Some common digestive system diseases include: 1. Gastroesophageal reflux disease (GERD) 2. Peptic ulcers 3. Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis 4. Irritable bowel syndrome (IBS) 5. Diverticulitis 6. Appendicitis 7. Pancreatitis 8. Cholecystitis 9. Hepatitis 10. Cirrhosis 11. Colorectal cancer 12. Celiac disease 13. Malabsorption syndromes, such as lactose intolerance and celiac disease. These diseases can cause a range of symptoms, including abdominal pain, bloating, nausea, vomiting, diarrhea, constipation, and weight loss. Treatment for digestive system diseases depends on the specific condition and may include medications, dietary changes, lifestyle modifications, and in some cases, surgery.
Urinary bladder diseases refer to a group of medical conditions that affect the urinary bladder, a muscular sac located in the pelvis that stores urine until it is eliminated from the body through the urethra. These diseases can affect the bladder's ability to empty completely, leading to urinary retention, or cause pain, discomfort, and other symptoms. Some common urinary bladder diseases include: 1. Urinary tract infections (UTIs): These are infections that occur in the urinary tract, including the bladder, urethra, kidneys, and ureters. UTIs can cause symptoms such as pain, burning, and frequent urination. 2. Overactive bladder (OAB): This is a condition in which the bladder contracts involuntarily, leading to frequent and urgent urination. OAB can be caused by a variety of factors, including age, genetics, and certain medical conditions. 3. Interstitial cystitis (IC): This is a chronic condition that causes pain, pressure, and discomfort in the bladder and surrounding areas. The exact cause of IC is not known, but it is thought to be related to inflammation and damage to the bladder lining. 4. Bladder stones: These are hard deposits that form in the bladder and can cause pain, discomfort, and difficulty urinating. Bladder stones can be caused by a variety of factors, including dehydration, certain medical conditions, and certain medications. 5. Bladder cancer: This is a type of cancer that starts in the cells of the bladder lining. Bladder cancer can cause symptoms such as blood in the urine, pain, and frequent urination.
Menstruation disturbances refer to any irregularities or abnormalities in the menstrual cycle, including changes in the frequency, duration, or amount of bleeding. These disturbances can be caused by a variety of factors, including hormonal imbalances, stress, illness, or certain medications. In the medical field, menstruation disturbances are often diagnosed and treated by a gynecologist or endocrinologist. Treatment options may include hormonal therapy, lifestyle changes, or other medical interventions, depending on the underlying cause of the disturbance.
Case-control studies are a type of observational study used in the medical field to investigate the relationship between an exposure and an outcome. In a case-control study, researchers identify individuals who have experienced a particular outcome (cases) and compare their exposure history to a group of individuals who have not experienced the outcome (controls). The main goal of a case-control study is to determine whether the exposure was a risk factor for the outcome. To do this, researchers collect information about the exposure history of both the cases and the controls and compare the two groups to see if there is a statistically significant difference in the prevalence of the exposure between the two groups. Case-control studies are often used when the outcome of interest is rare, and it is difficult or unethical to conduct a prospective cohort study. However, because case-control studies rely on retrospective data collection, they are subject to recall bias, where participants may not accurately remember their exposure history. Additionally, because case-control studies only provide information about the association between an exposure and an outcome, they cannot establish causality.
Choristoma is a medical term used to describe the abnormal growth of tissue that is not normally present in a particular location. It is a type of teratoma, which is a tumor that arises from the embryonic tissue. Choristomas can occur in various parts of the body, including the skin, liver, spleen, and brain. They are usually benign, meaning they are not cancerous, but they can sometimes cause problems if they grow too large or if they are located in a sensitive area. Treatment for choristomas typically involves surgical removal, although in some cases, they may not require any treatment if they are small and not causing any symptoms.
CA-125 antigen is a protein that is produced by some types of ovarian cancer cells. It is also produced by other types of cancer cells, as well as by non-cancerous cells in the body. The CA-125 antigen is measured in the blood to help diagnose and monitor ovarian cancer. A high level of CA-125 in the blood may indicate the presence of ovarian cancer, but it can also be elevated in other conditions, such as endometriosis, pelvic inflammatory disease, and pregnancy. Therefore, the CA-125 test is not used alone to diagnose ovarian cancer, but rather as part of a larger diagnostic workup.
Leuprolide is a medication that is used to treat various conditions related to the endocrine system, particularly in men. It is a synthetic version of the hormone luteinizing hormone-releasing hormone (LHRH), which is produced by the hypothalamus and regulates the production of other hormones in the body. Leuprolide is commonly used to treat prostate cancer, uterine fibroids, and endometriosis. It works by blocking the production of testosterone, which can help slow the growth of prostate cancer cells and reduce the size of uterine fibroids. It can also be used to treat precocious puberty in children. Leuprolide is usually administered as an injection, either under the skin or into a muscle. The dosage and frequency of the injections will depend on the specific condition being treated and the individual patient's response to the medication. Common side effects of leuprolide include hot flashes, decreased sex drive, breast tenderness, and injection site reactions.
Thoracic diseases refer to medical conditions that affect the chest and its organs, including the lungs, heart, esophagus, trachea, and pleura. These diseases can be acute or chronic and can range from mild to life-threatening. Some examples of thoracic diseases include: 1. Pneumonia: an infection of the lungs that can be caused by bacteria, viruses, or fungi. 2. Chronic obstructive pulmonary disease (COPD): a group of lung diseases that make it difficult to breathe, including emphysema and chronic bronchitis. 3. Asthma: a chronic inflammatory disease of the airways that causes wheezing, coughing, and shortness of breath. 4. Lung cancer: a type of cancer that starts in the lungs and can spread to other parts of the body. 5. Pulmonary embolism: a blockage of a blood vessel in the lungs, usually caused by a blood clot. 6. Congestive heart failure: a condition in which the heart is unable to pump blood effectively, leading to fluid buildup in the lungs and other parts of the body. 7. Pleurisy: inflammation of the lining of the lungs and chest wall, causing chest pain and difficulty breathing. 8. Esophageal cancer: a type of cancer that starts in the esophagus, the tube that carries food from the throat to the stomach. 9. Tuberculosis: a bacterial infection that primarily affects the lungs but can also affect other parts of the body. 10. Pulmonary hypertension: high blood pressure in the arteries of the lungs, which can lead to heart failure and other complications.
Infertility is a medical condition that affects a person's ability to conceive and carry a pregnancy to term. It is typically defined as the inability to conceive after one year of regular, unprotected sexual intercourse. Infertility can be caused by a variety of factors, including hormonal imbalances, structural problems with the reproductive organs, genetic disorders, infections, and environmental factors. Infertility can affect both men and women, and treatment options may vary depending on the underlying cause.
The abdominal wall is the outer layer of muscles and connective tissue that covers the abdominal cavity. It is composed of three layers: the superficial fascia, the rectus sheath, and the transversalis fascia. The abdominal wall serves as a protective barrier for the organs within the abdominal cavity and plays a role in supporting the trunk and maintaining posture. It also contains several muscles, including the rectus abdominis, external obliques, internal obliques, and transversus abdominis, which are responsible for movements such as breathing, digestion, and posture. Injuries or conditions that affect the abdominal wall can cause pain, weakness, and other symptoms.
Endometriosis
Cutaneous endometriosis
Thoracic endometriosis
Endometriosis and infertility
Worldwide Endometriosis March
Endometriosis Foundation of America
Endometriosis Society of India
Polyestriol phosphate
Estrogen-dependent condition
Female genital disease
Catholic theology of sexuality
Chamomile
Current Reviews in Obstetrics and Gynaecology
Medical reversal
Serdar Bulun
Hemoptysis
Solitary rectal ulcer syndrome
Camran Nezhat
CXorf66
Bridget Hustwaite
Neurocrine Biosciences
Emma Hardy
James Phelps (actor)
Menstruation
Lara Briden
Liselotte Mettler
Dydrogesterone
Devilskin
Stacey Missmer
Endometrosis
Endometriosis | Endo | MedlinePlus
Colorectal Endometriosis: Medical or Surgical Therapy?
Endometriosis (for Teens) - Akron Children's Hospital
Endometriosis | AAFP
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Endometriosis
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PRIME PubMed | Dysmenorrhea, absenteeism from school, and symptoms suspicious for endometriosis in adolescents
How Women with Endometriosis Can Stay on Track with Exercise - Sharecare
Laparoscopy9
- The most common surgery to diagnose endometriosis is a laparoscopy . (medlineplus.gov)
- Laparoscopy is also a way to treat endometriosis because the surgeon can remove growths in the abdomen and pelvis. (kidshealth.org)
- Laparoscopy is considered the primary diagnostic modality for endometriosis. (medscape.com)
- Laparoscopy is the standard modality for the diagnosis of endometriosis. (medscape.com)
- If she suspects endometriosis, she may suggest laparoscopy, surgery to take a close look at your reproductive organs, or an imaging test such as ultrasound. (medhelp.org)
- To receive a definitive endometriosis diagnosis, a laparoscopy must be performed. (zitawest.com)
- Specialists say the only definitive way to diagnose endometriosis is by a laparoscopy which involves the insertion of a camera into the pelvis via a small cut near the navel. (itv.com)
- Laparoscopy: Laparoscopy is considered the gold standard for the diagnosis of endometriosis. (patientsmedical.com)
- Then I had a laparoscopy (surgery used to diagnose-and sometimes treat-endometriosis) in 2020. (medlineplus.gov)
Endometrial tissue7
- Endometriosis (EN-doe-ME-tree-OH-sis) happens when endometrial tissue, the tissue that normally lines the inside of your uterus, grows outside of your uterus. (aafp.org)
- Endometriosis cysts may occur if endometrial tissue forms on the ovaries. (medicalnewstoday.com)
- [ 7 ] This theory also is supported by development of endometriosis in women who lack normal endometrial tissue, such as those with Turner syndrome or uterine agenesis . (medscape.com)
- therefore, endometrial tissue may continue to respond to estrogen levels, leading to familiar endometriosis symptoms. (healthnews.com)
- Endometriosis is a chronic condition in which the endometrial tissue, which normally lines the inside of the uterus, grows outside of it, most commonly on the ovaries, fallopian tubes and the tissue lining your pelvis. (patientsmedical.com)
- Immune system dysfunction: Some studies suggest that women with endometriosis may have an immune system dysfunction that allows the endometrial tissue to grow outside of the uterus. (patientsmedical.com)
- Endometriosis is diagnosed surgically when endometrial tissue is found outside the uterine cavity. (medscape.com)
Infertility2
- Infertility: Endometriosis can affect the functioning of the ovaries, fallopian tubes, and uterus, making it more difficult to conceive. (patientsmedical.com)
- We'll be seeing data in the [coming] months and years with regard to suppression for patients with infertility who have suspected endometriosis or some indication by tests, [which will help] improve implantation rates. (contemporaryobgyn.net)
Ovaries10
- Endometriosis most often is found along the Fallopian tubes, on the ovaries, or in the cul-de-sac. (medscape.com)
- Endometriosis can cause fluid-filled cysts, usually in or around the ovaries. (medicalnewstoday.com)
- When endometriosis occurs in the ovaries, ovarian cysts filled with blood can form. (medicalnewstoday.com)
- Doctors may refer to endometriosis cysts on the ovaries as chocolate cysts due to the color of the blood in them. (medicalnewstoday.com)
- Endometriosis is a relatively common condition that can affect the ovaries, fallopian tubes and tissues that line the pelvic floor. (newswise.com)
- These lesions can grow on the uterus, the fallopian tubes, the ovaries, and the intestines, the bladder, et cetera, and that is not normal," said Christine Metz, co-director of a study looking at the effects of endometriosis. (wxyz.com)
- The most common body areas where endometriosis growths occur are within the pelvic region, including on the ovaries, bladder, uterus, and fallopian tubes. (healthnews.com)
- Conservative surgery: If you have endometriosis and are trying to become pregnant, surgery to remove as much endometriosis as possible while preserving your uterus and ovaries may increase your chances of success. (apollohospitals.com)
- Endometriosis is a condition where tissue similar to the lining of the womb starts to grow in other places, such as the bowel, ovaries and fallopian tubes. (itv.com)
- Endometriosis is an often painful disease where tissue that looks like the lining of the uterus grows in other places in the body, including the ovaries, fallopian tubes, and bladder. (medlineplus.gov)
Uterus18
- Endometriosis is a disease in which tissue that is similar to the lining of the uterus grows in other places in your body. (medlineplus.gov)
- Endometriosis (pronounced: en-doh-mee-tree-OH-sis) happens when tissue that looks and acts like the lining of the uterus grows outside the uterus. (kidshealth.org)
- Endometriosis affects about 2% to 10% of people who have a uterus. (aafp.org)
- If you have endometriosis, the extra tissue growing outside of your uterus builds up and breaks down, too. (aafp.org)
- These cysts form because, in endometriosis, tissue similar to the endometrium, the lining of the uterus, develops outside of the uterus. (medicalnewstoday.com)
- Endometriosis implants may follow the same pattern as the lining of the uterus during the menstrual cycle, meaning it can swell and bleed during a menstrual period. (medicalnewstoday.com)
- Endometriosis is defined as the presence of endometrial glandular tissue outside of the uterus. (medscape.com)
- At least 5.5 million women in North America have endometriosis, a condition in which uterine tissue mistakenly grows outside of the uterus. (medhelp.org)
- With that in mind, he and his colleagues turned to gene expression profiling, single-cell RNA sequencing, and fluorescence in situ hybridization (FISH) to assess uterus endometrial fibroblast and ovarian endometriotic lesion samples from individuals with endometriosis and samples from unaffected controls. (genomeweb.com)
- The researchers carried out in-depth interviews with women aged from 16 to 45 about their experiences with endometriosis, which is caused when cells normally found in the uterus lodge in other parts of the body. (news-medical.net)
- She has endometriosis, which means the cells that are supposed to be on the inside of her uterus are found outside. (wxyz.com)
- Endometriosis is a condition in which cells that are usually found in our uterine lining are found elsewhere in the body and function in the same way as they would inside the uterus. (zitawest.com)
- For those with endometriosis, the cells which grow outside of the uterus react in the same way. (zitawest.com)
- My mom had a hysterectomy (and also ovary removal) for endometriosis, but obviously there's a potentially huge downside to that, depending on what plans you have for your uterus. (metafilter.com)
- Endometriosis is a condition in which the tissue that normally lines the inside of the uterus (the endometrium) grows outside of it. (patientsmedical.com)
- Endometriosis is a condition where tissue similar to the lining of the uterus grows outside the uterus, causing swelling, inflammation, and sometimes, severe pelvic pain. (sharecare.com)
- Endometriosis is a problem affecting a woman's uterus-the place where a baby grows when a woman is pregnant. (cdc.gov)
- Endometriosis is when the kind of tissue that normally lines the uterus grows somewhere else. (cdc.gov)
Diagnose endometriosis2
- How Do Health Care Providers Diagnose Endometriosis? (medlineplus.gov)
- Unfortunately, scans and blood tests cannot diagnose endometriosis. (zitawest.com)
Painful7
- Very painful menstrual cramps is the most common symptom of endometriosis. (kidshealth.org)
- Peritoneal endometriosis may include a range of symptoms, such as deep dyspareunia, painful defecation, chronic pelvic pain, and dysmenorrhea. (healthline.com)
- More than 50 percent of women with endometriosis experience dyspareunia, the clinical term for painful intercourse. (medhelp.org)
- Women with endometriosis can wait up to ten years for the painful gynaecological condition to be diagnosed, according to a paper in latest issue of UK-based Journal of Clinical Nursing . (news-medical.net)
- Endometriosis is generally painful (sometimes severely so) and can lead to abnormal menstruation, heavy cramping, and other pelvic health challenges. (healthnews.com)
- The unfortunate myth that endometriosis is linked to age has caused many teens and young women to suffer from painful endometriosis symptoms for years before finding relief. (healthnews.com)
- Take a tour into the female body to learn about endometriosis, a painful disorder that affects up to 10 percent of women of childbearing age. (sharecare.com)
Menstruation6
- Research has also linked endometriosis to retrograde menstruation. (newswise.com)
- The theory that retrograde menstruation causes endometriosis is supported by the analysis of peritoneal fluid in women. (medscape.com)
- The pattern of endometriosis is consistent with retrograde menstruation and is most common in the ovary, followed by the other dependent areas of the pelvis. (medscape.com)
- Extreme discomfort during menstruation is one of the classic symptoms of endometriosis, says Brown. (medhelp.org)
- Prior research had linked endometriosis risk to a process known as retrograde menstruation, which involves backwards menstrual blood movement into the fallopian tubes and pelvic cavity rather than out of the body via the vagina. (genomeweb.com)
- Even so, endometriosis does not always turn up in individuals experiencing retrograde menstruation, which is relatively common in reproductive-age women, senior and corresponding author Yutaka Kondo, a cancer biologist at Nagoya University, said in an email. (genomeweb.com)
Cause of endometriosis6
- The cause of endometriosis is unknown. (medlineplus.gov)
- Doctors don't know the exact cause of endometriosis. (kidshealth.org)
- While doctors can't pinpoint the exact cause of endometriosis, several possible causes have been proposed. (newswise.com)
- The exact cause of endometriosis is not known, but it is thought to be related to the retrograde flow of menstrual blood. (patientsmedical.com)
- The exact cause of endometriosis is not fully understood, but there are several theories that have been proposed. (patientsmedical.com)
- It is important to note that the exact cause of endometriosis is not known and that it can be multifactorial. (patientsmedical.com)
Development of endometriosis5
- NEW YORK - New research suggests bacteria may spur on the development of endometriosis, a condition marked by tissue growth outside of the endometrial cavity. (genomeweb.com)
- T his suggests the existence of other specific mechanisms in the endometrium that facilitate the development of endometriosis in patients," Kondo explained, noting that "there is no conclusive explanation about this question so far. (genomeweb.com)
- The TAGLN-positive cells, in turn, appeared to take on new proliferation, migration, and adherence capabilities in the lab, the researchers reported, hinting at a similar transformation during the development of endometriosis. (genomeweb.com)
- Genetic predisposition: Research suggests that there may be a genetic component to the development of endometriosis. (patientsmedical.com)
- According to recent studies these patients are at higher risk of further development of endometriosis, whereas the knowledge of the disease is low among the adolescents investigated, so those involved with adolescents both in the health profession and particularly in schools and Family Counseling Services should be educated about endometriosis and its symptoms to reduce the significant lag time between symptoms and diagnosis. (unboundmedicine.com)
Pathogenesis of endometriosis2
- Two main theories exist for the pathogenesis of endometriosis. (medscape.com)
- Our data support a mechanism for the pathogenesis of endometriosis via Fusobacterium infection and suggest that eradication of this bacterium could be an approach to treat endometriosis," Kondo and his colleagues wrote. (genomeweb.com)
Fallopian1
- Scarring in the pelvis and abdomen from endometriosis can block the fallopian tubes, distort normal anatomy, and even affect the function of organs, such as the bowels and bladder. (medicalnewstoday.com)
Hysterectomy4
- Short of a hysterectomy, there's no cure for endometriosis. (newswise.com)
- Such surgery involves hysterectomy and cytoreduction of pelvic endometriosis. (medscape.com)
- Radical surgery involves total hysterectomy with bilateral oophorectomy (TAH-BSO) and cytoreduction of visible endometriosis. (medscape.com)
- Ciancarelli had several surgeries for her endometriosis, including a hysterectomy, before finally finding relief. (wxyz.com)
Cutaneous Endometriosis3
- What Is Cutaneous Endometriosis? (healthline.com)
- Cutaneous endometriosis is a rare form of endometriosis in which uterine-like tissue grows and sheds on the skin. (healthline.com)
- Primary cutaneous endometriosis of the umbilicus. (bvsalud.org)
Endometrium2
- Although further studies are needed, our data suggest that targeting Fusobacterium in the endometrium by antibiotic treatment may be a therapeutic option for patients with endometriosis," the authors concluded. (genomeweb.com)
- endometriosis occurs when tissue similar to the endometrium affects the peritoneum, which can infiltrate structures and organs such as the bowel, ureter, bladder or vagina and is usually accompanied by an inflammatory process. (bvsalud.org)
Surgical9
- Surgical treatments for severe pain, including procedures to remove the endometriosis patches or cut some nerves in the pelvis. (medlineplus.gov)
- Colorectal Endometriosis: Medical or Surgical Therapy? (medscape.com)
- A recent parallel cohort study [ 2 ] compared the efficacy of surgical versus medical treatment for colorectal endometriosis. (medscape.com)
- Symptomatic endometriosis requires treatment (surgical or medical) because it has a significant negative impact on quality of life. (medscape.com)
- The participants in this study were referred for surgery owing to endometriosis infiltrating the bowels, but a thorough discussion about the pros and cons of medical versus surgical treatment took place before a decision was made. (medscape.com)
- Surgical Lead of EXPPECT Endometriosis. (ed.ac.uk)
- Our study found that although the pain of endometriosis can be severe and unrelenting, our interviewees reported that advice and support from health professionals was limited to surgical and hormonal remedies. (news-medical.net)
- There is no single cure for endometriosis, including surgical procedures. (healthnews.com)
- Medical and surgical therapies can offer symptomatic relief, because endometriosis itself cannot be cured. (medscape.com)
Peritoneal2
- The theory that metaplasia causes endometriosis is supported by the fact that endometrial cells and peritoneal cells derive from the same celomic wall epithelium. (medscape.com)
- [ 3 ] The earliest visible manifestations of endometriosis are whitish peritoneal plaques. (medscape.com)
Affects4
- Endometriosis is fairly common - it affects about 10% of people assigned female at birth. (healthline.com)
- Endometriosis is a sometimes life-altering condition that affects as many as 10% of women of childbearing age. (wxyz.com)
- Endometriosis is a condition that primarily affects the female pelvic region. (healthnews.com)
- Anna and Charlotte share their experiences of the pain of living with endometriosis, a condition that affects 1 in 10 women and those assigned female at birth in the UK and can take years to diagnose. (itv.com)
Benign gynecologic3
- Endometriosis (stroma plus glands in extrauterine locations) is a common, benign gynecologic problem. (medscape.com)
- Endometriosis is a common benign gynecologic disease that can be detected in 10%-15% of the general population. (medscape.com)
- Endometriosis is a benign gynecologic disease, although the associated symptoms can significantly affect a woman's quality of life. (medscape.com)
Pelvic exam1
- Pelvic exam: During a pelvic exam, a healthcare professional may be able to feel nodules or masses in the pelvic area that may indicate endometriosis. (patientsmedical.com)
Risk of endometriosis3
- Do Taller, Thinner Girls Really Have a Higher Risk of Endometriosis? (healthline.com)
- Researchers say tall, thin girls appear to have a higher risk of endometriosis, but other experts say endometriosis itself can produce leaner bodies. (healthline.com)
- This suggests that some aspect of work scheduling is associated with increased risk of endometriosis, or endometriosis symptoms might affect how flight attendants schedule their flights. (cdc.gov)
Cure for endometriosis3
- There is no cure for endometriosis, but there are treatments for the symptoms. (medlineplus.gov)
- There is no cure for endometriosis, but treatment of its symptoms is often required. (medscape.com)
- Although there is no known cure for endometriosis, treatment is possible. (healthnews.com)
Treatment14
- Overall, after 3 years of follow-up, more than two thirds of women who chose medical therapy for deep infiltrating endometriosis were satisfied with their treatment. (medscape.com)
- Treatment for endometriosis and its related cysts usually involves hormonal medication. (medicalnewstoday.com)
- The constant pain, vomiting and loss of consciousness that Sarah - then 17 - experienced due to endometriosis was unbearable, and seven years without successful treatment meant that she needed an out. (refinery29.com)
- Faye Farthing, communications manager at Endometriosis UK , told Refinery29 that nobody suffering with endometriosis should be dismissed or made to feel that their pain isn't valid because the treatment they want could affect their fertility. (refinery29.com)
- For those with endometriosis where fertility is not a concern or priority, people shouldn't feel that they have to battle for treatment and support," she explained. (refinery29.com)
- In recent years, renewed or perhaps new attention to the causes, prevalence, and challenges women with endometriosis face has helped provide a better understanding of care and treatment options. (healthnews.com)
- Several common myths and misconceptions are key to why many women experience challenges receiving an accurate diagnosis and effective endometriosis treatment. (healthnews.com)
- One treatment some have for endometriosis is being 'put' into a medical menopause. (endometriosis-uk.org)
- promoting early access to intervention, care, treatment options, and referral services for endometriosis and pelvic pain. (health.gov.au)
- This evaluation will help integrate available support into the treatment and management of people with coexisting conditions such as endometriosis. (health.gov.au)
- a review of the Medicare Benefits Schedule and Pharmaceutical Benefits Scheme items used to support the diagnosis and treatment of endometriosis. (health.gov.au)
- If you suspect you have endometriosis, it's important to speak with a healthcare professional for an accurate diagnosis and treatment options. (patientsmedical.com)
- Many women with endometriosis suffer in silence but treatment can ease their symptoms and help preserve their fertility. (sharecare.com)
- Since her diagnosis and successful treatment, Culpo has become an advocate for others with endometriosis. (medlineplus.gov)
Fertility2
- About 30 to 40 percent of women with endometriosis have fertility troubles, according to the Cleveland Clinic. (medhelp.org)
- Within certain cultures and communities, this taboo and expectation can be even more prevalent, which makes living with menstrual health conditions like endometriosis that may affect fertility all the more difficult and complex, or if women decide they don't want children at all. (refinery29.com)
Pregnant4
- In milder cases of endometriosis, surgery to remove affected tissue can sometimes allow people to get pregnant. (aafp.org)
- Many women don't know they have endometriosis until they have trouble becoming pregnant. (medhelp.org)
- And for a start heaps of women with endometriosis can't get pregnant anyway. (news-medical.net)
- Some women have no symptoms at all, and having trouble getting pregnant may be the first sign they have endometriosis. (cdc.gov)
Pain30
- Pain relievers , including nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen and a prescription medicine specifically for endometriosis. (medlineplus.gov)
- Lots of people get period pain and the other symptoms listed above that aren't due to endometriosis. (kidshealth.org)
- If the doctor thinks someone has endometriosis, the first step is to treat it with pain relievers, like ibuprofen, and hormone therapy like some types of birth control. (kidshealth.org)
- But when combined with hormone therapy, like birth control pills , the birth control shot , or an IUD, it can help control pain and prevent endometriosis from getting worse. (kidshealth.org)
- Hormone therapies such as hormonal contraceptives (birth control) are used to reduce or stop pain caused by endometriosis. (aafp.org)
- Interstitial cystitis and endometriosis are common causes of pelvic pain. (healthline.com)
- For most patients, the most common symptom of endometriosis is severe pelvic pain. (newswise.com)
- He subsequently developed both clinical and research interests in pelvic pain and endometriosis, and established EXPPECT Edinburgh. (ed.ac.uk)
- In 2021, in recognition of his research into pelvic pain and endometriosis, he was elected to the Fellowship of the Royal Society of Edinburgh. (ed.ac.uk)
- Many women with endometriosis feel pain in the pelvic region. (medhelp.org)
- Their experiences have led researchers from New Zealand's Massey University to call for greater awareness of endometriosis and the development of "long overdue" pain management services for sufferers. (news-medical.net)
- As well as causing them severe pain, endometriosis also had a negative impact on other areas of their life, such as their ability to work, family relationships and self-esteem. (news-medical.net)
- The development of chronic pain management services for women with endometriosis is long overdue" adds Professor Huntington. (news-medical.net)
- At 18, Rachel was in the same situation as Sarah, having severe endometriosis which caused pain that impacted every area of their daily life. (refinery29.com)
- We are establishing endometriosis and pelvic pain clinics across Australia to provide more appropriate and timelier endometriosis care and management. (health.gov.au)
- This will lead to reduced diagnosis timeframes and better pain management for those suffering from endometriosis and pelvic pain. (health.gov.au)
- The Australian Government is funding endometriosis and pelvic pain clinics in every state and territory in Australia. (health.gov.au)
- If you have severe pain from endometriosis, you may also benefit from surgery however, endometriosis and pain may return. (apollohospitals.com)
- Hormone therapy: Supplemental hormones are sometimes effective in reducing or eliminating the pain of endometriosis. (apollohospitals.com)
- Suffering intense stomach pain, vomiting, and spending hours on the toilet in agonising pain has become normal as they live with endometriosis. (itv.com)
- With regular periods, the lining of the womb sheds monthly building up to menstrual bleeding, but the tissue from endometriosis has nowhere to go - the scar-like tissue can fuse organs together, causing inflammation and pain to those who have it. (itv.com)
- Speaking to a ITV Wales programme about the condition, 'Living in Pain', she said: "I'm determined as the first woman health minister [in Wales] for a very long time to make sure more focus is put into women's health issues, and endometriosis is one of those. (itv.com)
- Pelvic pain: This is the most common symptom of endometriosis and can be felt in the lower back, abdomen, and pelvis. (patientsmedical.com)
- 68% (170/250) of the participants complain of dysmenorrhea, 12% (30/250) lose days of school/work monthly because of dysmenorrhea, 13% (33/250) complain of intermenstrual pain which limits daily activities, 27% (56/208) of the adolescents who are sexually active complain of dyspareunia, 82% (203/250) have never heard about endometriosis and 80% (200/250) would like to know more about it. (unboundmedicine.com)
- Learn how those with endometriosis can stay on track with exercise, which may help reduce pain and stress. (sharecare.com)
- Research suggests exercise may help manage endometriosis-related pain and stress. (sharecare.com)
- Of course, being told that working out helps relieve endometriosis is one thing, but living through the cramps, heavy periods, and lower back pain is another story. (sharecare.com)
- Even on difficult days when endometriosis is keeping you down, 5 to 10 minutes of exercising may help ease the pain. (sharecare.com)
- For women with endometriosis, exercising may help cope with stress, reduce pain, and act as a distraction from endometriosis. (sharecare.com)
- Learn how exercise can ease symptoms of endometriosis, like pain and stress, and improve overall well-being. (sharecare.com)
Dyspareunia1
- Other outcomes were impairment of daily activities, dyspareunia, and awareness of endometriosis as a pathologic condition. (unboundmedicine.com)
Causes endometriosis2
- What causes endometriosis? (medlineplus.gov)
- We are unsure what exactly causes endometriosis. (zitawest.com)
Uterine3
- Endometriosis is defined as the presence of normal endometrial mucosa (glands and stroma) abnormally implanted in locations other than the uterine cavity (see the image below). (medscape.com)
- Histologic demonstration of a combination of endometrial glands and stroma in biopsy specimens obtained from outside the uterine cavity is required to make the diagnosis of endometriosis. (medscape.com)
- [ 7 ] In addition, teenage girls with obstructive uterine or vaginal anomalies show retrograde menstrual bleeding, and endometriosis is common in these patients. (medscape.com)
Bowels1
- Extrapelvic endometriosis can affect the bladder, bowels, and chest. (healthline.com)
Patients7
- Patients with endometriosis do not frequently have any physical examination findings beyond tenderness related to the site of involvement. (medscape.com)
- Struggling with mental health problems is common among endometriosis patients, one in five of whom also have a diagnosis of depression and almost a third of whom live with anxiety . (refinery29.com)
- Forty-six percent of the 10,000 endometriosis patients who responded to the survey found their GP(s) unhelpful or very unhelpful when it came to the support of gynaecological health problems, and 32% found their gynaecologist(s) unhelpful or very unhelpful. (refinery29.com)
- One is for patients who have extra pelvic endometriosis. (contemporaryobgyn.net)
- Below are 5 ways endometriosis patients can stay on track with exercise, even when it seems near impossible. (sharecare.com)
- [ 5 ] and has been proposed to relate to the induction of carcinomas in endometriosis that form in some patients. (medscape.com)
- The clinical and epidemiological data of patients with Deep endometriosis (DE) available in the literature come from studies whose samples were selected by surgery, therefore subject to selection bias. (bvsalud.org)
Women21
- Women 18-50 years of age with deep infiltrating intestinal endometriosis were invited to participate. (medscape.com)
- How Many Women Have Endometriosis? (healthline.com)
- Many people with endometriosis are women. (healthline.com)
- Affecting one in 10 women, endometriosis is a condition that most women suffer with in silence. (newswise.com)
- Dr. Yang said Endometriosis Awareness Month can educate and empower women. (newswise.com)
- Dr. Yang advises women with endometriosis to self-advocate and speak up during doctor visits. (newswise.com)
- Approximately 30-40% of women with endometriosis will be subfertile. (medscape.com)
- About one third of women with endometriosis remain asymptomatic. (medscape.com)
- For instance, while mid-cycle bleeding can occur in women with endometriosis, it is more likely caused by a hormonal imbalance such as polycystic ovarian syndrome. (medhelp.org)
- However, once the women were referred to a gynaecologist, endometriosis was promptly diagnosed. (news-medical.net)
- The Rose Study needs menstrual blood from women, whether they have endometriosis or not. (wxyz.com)
- Statistics provided by the U.S. Department of Health and Human Services Office on Women's Health suggest more than 11% of American women ages 15 to 44 live with endometriosis. (healthnews.com)
- Most researchers believe between 60 and 70% of women with endometriosis are fertile. (healthnews.com)
- For many years, medical community members did not "look for" endometriosis in young women and teens. (healthnews.com)
- Both women rely on the online endometriosis community for support, as they were offered no help in dealing with the emotional impact of living with the condition. (itv.com)
- Less than 3% of medical research funding in the UK is focused on women-specific diseases like endometriosis, according to the Royal College of Obstetricians and Gynecologists. (itv.com)
- Heavy or irregular periods: Some women with endometriosis may experience heavy or prolonged periods. (patientsmedical.com)
- Fatigue: Some women with endometriosis may experience fatigue and lack of energy. (patientsmedical.com)
- It's important to note that not all women with endometriosis will experience all of these symptoms, and some women may not have any symptoms at all. (patientsmedical.com)
- If you are living with with endometriosis-like an estimated 176 million women worldwide are-then it's safe to say finding relief and ways of coping are of upmost importance. (sharecare.com)
- I saw so many blogs, videos, and posts from women with endometriosis, and I could relate to so many of them. (medlineplus.gov)
20201
- On average it can take up to seven to eight years to be diagnosed with endometriosis from when you start displaying symptoms, according to a 2020 report by the All Party Parliamentary Group on Endometriosis. (itv.com)
Dysmenorrhea1
- To quantify in adolescents the prevalence of dysmenorrhea and other symptoms found to be suggestive of future diagnosis of endometriosis, in particular their impact on monthly absenteeism from school/work, activity impairment, and sexual life and to quantify the awareness of endometriosis in adolescents. (unboundmedicine.com)
Women's Health1
- In Wales, the Women's Health Implementation Group (WHIG), has recently supported the recruitment of specialist endometriosis nurses in each health board to develop new ways of working to reduce diagnostic times across Wales. (itv.com)
Gynaecologist1
- I was lucky enough to be able to afford to see a private gynaecologist, and the same day had tests on the suspicion that I had endometriosis. (zitawest.com)
Ultrasound2
- A standard ultrasound imaging test won't definitively tell your doctor whether you have endometriosis. (itv.com)
- MRI: Magnetic resonance imaging (MRI) can also be used to create images of the pelvic area, and may be more accurate than ultrasound in detecting endometriosis. (patientsmedical.com)
Difficult to diagnose2
- As the symptoms of endometriosis can be broad and overlap with other conditions, endometriosis can be difficult to diagnose. (zitawest.com)
- Endometriosis is a condition that can be difficult to diagnose because its symptoms can be similar to those of other conditions. (patientsmedical.com)
Ovarian2
- Although rare, endometriosis can result in a ruptured ovarian cyst . (medicalnewstoday.com)
- Ovarian endometriosis can be removed surgically, because one tenth of functioning ovarian tissue is all that is needed for hormone production. (medscape.com)
Menstrual health1
- After her experience with receiving conflicting medical advice, Anna launched her own platform The Menstrual Health project to help better support the endometriosis community online. (itv.com)
Common4
- While many with endometriosis don't even know they have the disease-it can impact any menstruating woman-awareness of the most common warning signs can help cut short suffering for anyone affected. (medhelp.org)
- The three most common symptoms of endometriosis, along with a fourth potential sign all raise a red flag for doctors, says MedHelp OB/GYN expert Elaine Brown, MD. (medhelp.org)
- Several common symptoms that are often attributed to endometriosis are more likely due to other causes, says Brown. (medhelp.org)
- Here's how to dispel common misconceptions about endometriosis and get the care you need. (sharecare.com)
Clinical2
- EXPPECT Endometriosis & EXPPECT Research Lead for Clinical Studies. (ed.ac.uk)
- Adenomyosis once was termed endometriosis interna but currently is recognized as a distinct clinical entity. (medscape.com)
Adolescents3
- We use a lot of GNRH agonists for precocious puberty, although the length of duration of those therapies aren't as long, so I'm not sure if it can necessarily be extrapolated for adolescents with endometriosis. (contemporaryobgyn.net)
- I haven't seen as much data on GNRH antagonists in adolescents with endometriosis, though. (contemporaryobgyn.net)
- I am so excited to continue my work with them around the ENPOWR™ (ENdometriosis: Promoting Outreach and Wide Recognition)* program for adolescents later this year, which will bring a curriculum about endometriosis to schools. (medlineplus.gov)
Deep infiltrating1
- Deep infiltrating endometriosis (DIE) represents 15 to 30% of endometriosis cases and is defined as endometriosis infiltrating the peritoneum by more than 5 mm. (medscape.com)
Gastrointestinal2
- And gastrointestinal discomfort, while it can be associated with endometriosis, is more often seen as a result of an intestinal disorder like irritable bowel syndrome. (medhelp.org)
- Gastrointestinal symptoms: Endometriosis can also cause constipation, diarrhea, and bloating during periods. (patientsmedical.com)
Cases of endometriosis1
- In addition, rare cases of endometriosis have been found in the prostatic utricle of men. (medscape.com)
Signs of Endometriosis1
- This camera looks for signs of endometriosis. (zitawest.com)
Management of Endometriosis1
- Management of endometriosis can differ depending on age, severity and type of symptoms and whether you are ready to conceive. (zitawest.com)
Treatments for endometriosis1
- What are the treatments for endometriosis? (medlineplus.gov)
Surgery11
- Surgery is the only way to know for sure that you have endometriosis. (medlineplus.gov)
- Surgery involves resection, excision, or ablation of endometriosis. (medscape.com)
- Endometriosis cannot be diagnosed for sure without surgery. (aafp.org)
- After obtaining a UK wide competitive entry advanced training post in endometriosis and minimal access surgery, she spent 2 years in Bristol (Southmead Hospital) where she worked in a nationally recognised BSGE Endometriosis Centre. (ed.ac.uk)
- His area of expertise lies in Minimal Access Surgery with a special interest in Endometriosis. (ed.ac.uk)
- After obtaining a UK wide competitive entry advanced training post in endometriosis and minimal access surgery, he spent the final two years of his postgraduate training in Edinburgh as part of the EXPPECT nationally recognised BSGE Endometriosis Centre. (ed.ac.uk)
- During this time he focussed on Endometriosis surgery and Medical Education. (ed.ac.uk)
- The results of a Cochrane Systematic Review of imaging modalities for the noninvasive diagnosis of endometriosis concluded that none of the imaging modalities were able to detect overall pelvic endometriosis with enough accuracy to replace surgery. (medscape.com)
- Jane, who had been misdiagnosed with irritable bowel syndrome, raised the issue of endometriosis after her husband recognised the symptoms in a magazine article he was reading in the doctor's surgery. (news-medical.net)
- Anna was misdiagnosed, only finding out she had endometriosis after she had to have surgery to remove her appendix. (itv.com)
- With the average a wait for surgery for endometriosis being 6-7 years, Anna says that while the pandemic has made this worse, the lack of surgeons was a problem way before Covid. (itv.com)
