Encephalomyelitis, Autoimmune, Experimental
An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Encephalomyelitis
Encephalomyelitis, Acute Disseminated
An acute or subacute inflammatory process of the CENTRAL NERVOUS SYSTEM characterized histologically by multiple foci of perivascular demyelination. Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified. Clinical manifestations include CONFUSION, somnolence, FEVER, nuchal rigidity, and involuntary movements. The illness may progress to COMA and eventually be fatal. (Adams et al., Principles of Neurology, 6th ed, p921)
Myelin-Oligodendrocyte Glycoprotein
Encephalomyelitis, Equine
A group of ALPHAVIRUS INFECTIONS which affect horses and man, transmitted via the bites of mosquitoes. Disorders in this category are endemic to regions of South America and North America. In humans, clinical manifestations vary with the type of infection, and range from a mild influenza-like syndrome to a fulminant encephalitis. (From Joynt, Clinical Neurology, 1996, Ch26, pp8-10)
Myelin Basic Protein
Myelin-Associated Glycoprotein
Myelin Proteins
Myelin Proteolipid Protein
A myelin protein that is the major component of the organic solvent extractable lipoprotein complexes of whole brain. It has been the subject of much study because of its unusual physical properties. It remains soluble in chloroform even after essentially all of its bound lipids have been removed. (From Siegel et al., Basic Neurochemistry, 4th ed, p122)
Theilovirus
Multiple Sclerosis
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Spinal Cord
Demyelinating Diseases
Central Nervous System
Encephalomyelitis Virus, Avian
Maus Elberfeld virus
Encephalitis Viruses
Encephalomyelitis, Eastern Equine
A form of arboviral encephalitis (primarily affecting equines) endemic to eastern regions of North America. The causative organism (ENCEPHALOMYELITIS VIRUS, EASTERN EQUINE) may be transmitted to humans via the bite of AEDES mosquitoes. Clinical manifestations include the acute onset of fever, HEADACHE, altered mentation, and SEIZURES followed by coma. The condition is fatal in up to 50% of cases. Recovery may be marked by residual neurologic deficits and EPILEPSY. (From Joynt, Clinical Neurology, 1996, Ch26, pp9-10)
Peptide Fragments
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Encephalitis Virus, Venezuelan Equine
Encephalitis Virus, Eastern Equine
A species of ALPHAVIRUS causing encephalomyelitis in Equidae and humans. The virus ranges along the Atlantic seaboard of the United States and Canada and as far south as the Caribbean, Mexico, and parts of Central and South America. Infections in horses show a mortality of up to 90 percent and in humans as high as 80 percent in epidemics.
Myelin Sheath
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Adoptive Transfer
Interleukin-17
Demyelinating Autoimmune Diseases, CNS
Encephalitis Virus, Western Equine
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Th1 Cells
Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
Encephalomyelitis, Enzootic Porcine
Th17 Cells
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Fatigue Syndrome, Chronic
A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Disease Models, Animal
Autoimmunity
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Encephalomyelitis, Western Equine
A form of arboviral encephalitis (which primarily affects horses) endemic to western and central regions of NORTH AMERICA. The causative organism (ENCEPHALOMYELITIS VIRUS, WESTERN EQUINE) may be transferred to humans via the bite of mosquitoes (CULEX tarsalis and others). Clinical manifestations include headache and influenza-like symptoms followed by alterations in mentation, SEIZURES, and COMA. DEATH occurs in a minority of cases. Survivors may recover fully or be left with residual neurologic dysfunction, including PARKINSONISM, POSTENCEPHALITIC. (From Joynt, Clinical Neurology, 1996, Ch26, pp8-9)
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Mice, Transgenic
Oligodendroglia
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
Freund's Adjuvant
An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.
Glycoproteins
Autoimmune Diseases
Autoantigens
T-Lymphocyte Subsets
Enterovirus
Encephalomyelitis, Venezuelan Equine
A form of arboviral encephalitis endemic to Central America and the northern latitudes of South America. The causative organism (ENCEPHALITIS VIRUS, VENEZUELAN EQUINE) is transmitted to humans and horses via the bite of several mosquito species. Human viral infection may be asymptomatic or remain restricted to a mild influenza-like illness. Encephalitis, usually not severe, occurs in a small percentage of cases and may rarely feature SEIZURES and COMA. (From Joynt, Clinical Neurology, 1996, Ch26, pp9-10)
Encephalitis, Viral
Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.
Paralysis
Coronavirus Infections
T-Lymphocytes, Regulatory
Microglia
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Cells, Cultured
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Blood-Brain Barrier
Epitopes, T-Lymphocyte
Interleukin-10
A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.
Inflammation
Lymph Nodes
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)
Arboviruses
Arthropod-borne viruses. A non-taxonomic designation for viruses that can replicate in both vertebrate hosts and arthropod vectors. Included are some members of the following families: ARENAVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; TOGAVIRIDAE; and FLAVIVIRIDAE. (From Dictionary of Microbiology and Molecular Biology, 2nd ed)
Astrocytes
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Muscle Rigidity
Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Pleurodynia, Epidemic
Antigen-Presenting Cells
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Disease Susceptibility
T-Lymphocytes, Helper-Inducer
Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions.
Th2 Cells
Receptors, Antigen, T-Cell, alpha-beta
Receptors, Antigen, T-Cell
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Injections, Subcutaneous
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Cardiovirus
Paraneoplastic Syndromes, Nervous System
Degenerative or inflammatory conditions affecting the central or peripheral nervous system that develop in association with a systemic neoplasm without direct invasion by tumor. They may be associated with circulating antibodies that react with the affected neural tissue. (Intern Med 1996 Dec;35(12):925-9)
Cell Movement
Injections, Intraperitoneal
Callithrix
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Cell Differentiation
Nervous System Autoimmune Disease, Experimental
Experimental animal models for human AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM. They include GUILLAIN-BARRE SYNDROME (see NEURITIS, AUTOIMMUNE, EXPERIMENTAL); MYASTHENIA GRAVIS (see MYASTHENIA GRAVIS, AUTOIMMUNE, EXPERIMENTAL); and MULTIPLE SCLEROSIS (see ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL).
Histocompatibility Antigens Class II
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Murine hepatitis virus
Immunologic Factors
Forkhead Transcription Factors
Guinea Pigs
Interleukin-4
Immunization, Passive
Interleukin-23
Alphavirus Infections
Optic Neuritis
Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Immunohistochemistry
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Dendritic Cells
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Glial Fibrillary Acidic Protein
Disease Progression
Coronavirus
Hu Paraneoplastic Encephalomyelitis Antigens
Antigens, CD80
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Severity of Illness Index
Autoantibodies
Central Nervous System Diseases
Sodium Benzoate
Horses
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Sindbis Virus
The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.
HLA-DR2 Antigen
Coronavirus OC43, Human
Myelitis
Inflammation of the spinal cord. Relatively common etiologies include infections; AUTOIMMUNE DISEASES; SPINAL CORD; and ischemia (see also SPINAL CORD VASCULAR DISEASES). Clinical features generally include weakness, sensory loss, localized pain, incontinence, and other signs of autonomic dysfunction.
Gene Expression Regulation
Interleukin-12
A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
Encephalitis, Arbovirus
Infections of the brain caused by arthropod-borne viruses (i.e., arboviruses) primarily from the families TOGAVIRIDAE; FLAVIVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; and RHABDOVIRIDAE. Life cycles of these viruses are characterized by ZOONOSES, with birds and lower mammals serving as intermediate hosts. The virus is transmitted to humans by the bite of mosquitoes (CULICIDAE) or TICKS. Clinical manifestations include fever, headache, alterations of mentation, focal neurologic deficits, and COMA. (From Clin Microbiol Rev 1994 Jan;7(1):89-116; Walton, Brain's Diseases of the Nervous System, 10th ed, p321)
Nidovirales Infections
Integrin alpha4
Immunity, Innate
Magnetic Resonance Imaging
Teschovirus
Dose-Response Relationship, Immunologic
Glia Maturation Factor
Down-Regulation
Nuclear Receptor Subfamily 1, Group F, Member 3
Encephalitis
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Antigen Presentation
The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)
Immunodominant Epitopes
Chemokines
Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
CD8-Positive T-Lymphocytes
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Neuroprotective Agents
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Up-Regulation
Hypersensitivity, Delayed
Antibodies
Neutralization Tests
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
Reverse Transcriptase Polymerase Chain Reaction
Optic Nerve
The 2nd cranial nerve which conveys visual information from the RETINA to the brain. The nerve carries the axons of the RETINAL GANGLION CELLS which sort at the OPTIC CHIASM and continue via the OPTIC TRACTS to the brain. The largest projection is to the lateral geniculate nuclei; other targets include the SUPERIOR COLLICULI and the SUPRACHIASMATIC NUCLEI. Though known as the second cranial nerve, it is considered part of the CENTRAL NERVOUS SYSTEM.
Meninges
Cricetinae
Interleukins
Central Nervous System Viral Diseases
Gliosis
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Viruses
Paraneoplastic Syndromes
Inflammation Mediators
Alphavirus
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Interleukin-23 Subunit p19
Crosses, Genetic
Immunomodulation
Alteration of the immune system or of an immune response by agents that activate or suppress its function. This can include IMMUNIZATION or administration of immunomodulatory drugs. Immunomodulation can also encompass non-therapeutic alteration of the immune system effected by endogenous or exogenous substances.
Viral Vaccines
Cell Migration Inhibition
Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.
Chemokine CCL2
B-Lymphocytes
Molecular Mimicry
Th1-Th2 Balance
Interleukin-2
Mice, Congenic
Hemagglutination Inhibition Tests
Cerebrospinal Fluid
Clonal Anergy
Immunosuppression
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Antigens, CD274
Vaccination
Paraneoplastic Polyneuropathy
A diffuse or multifocal peripheral neuropathy related to the remote effects of a neoplasm, most often carcinoma or lymphoma. Pathologically, there are inflammatory changes in peripheral nerves. The most common clinical presentation is a symmetric distal mixed sensorimotor polyneuropathy. (Adams et al., Principles of Neurology, 6th ed, p1334)
Coculture Techniques
Propylene Glycols
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Non-coding plasmid DNA induces IFN-gamma in vivo and suppresses autoimmune encephalomyelitis. (1/278)
Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-gamma. (+info)Non-purulent meningoencephalomyelitis of a Pacific striped dolphin (Lagenorhynchus obliquidens). The first evidence of morbillivirus infection in a dolphin at the Pacific Ocean around Japan. (2/278)
On March 22, 1998, a mature, male, hyposthenic Pacific striped dolphin (Lagenorhynchus obliquidens) was stranded at Aoshima Beach in Miyazaki prefecture, Japan. A necropsy performed 14 hr after death revealed mild diffuse congestion and edema of the leptomeninges and mild pulmonary atelectasis. Histopathologically, non-purulent inflammatory were observed throughout the cerebrum, thalamus, midbrain, pons, medulla oblongata, and spinal cord. Hematoxylin and eosin stain revealed no viral inclusion bodies. Immunohistochemistry using a monoclonal antibody against nucleoprotein of canine distemper virus (CDV-NP) revealed a number of CDV-NP-positive granular deposits in the cytoplasm and cell processes of the degenerating or intact neurons. The present paper is a first report of spontaneously occurred morbillivirus infection in a dolphin at the Pacific Ocean around Japan. (+info)Immunity to heat shock proteins and neurological disorders of women. (3/278)
Stress or heat shock proteins are constitutively expressed in normal CNS tissues in a variety of cell types (oligodendrocytes, astrocytes, and neurons). Their presence may protect cells from various stresses, such as hypoxia, anoxia, and excessive excitatory stimulation. Increased amounts of hsp are expressed in various cells of the CNS during acute toxic-metabolic states and in chronic degenerative and inflammatory diseases. Increased expression of hsp may lead to immune responses to these proteins. Antibodies to mycobacterial hsp bind to normal human myelin and to oligodendrocytes in regions of MS demyelination. Cellular immune responses to hsp occur with increased frequency and magnitude in persons with MS, especially those with recent onset of disease. In addition, there are populations of T cells expressing gamma/delta T cells in the brains and spinal fluids of persons with MS, suggesting an in situ immune response to hsps. Humoral immune responses to hsp are found in CSF, but no disease specificity has been documented. Some myelin proteins have sequence homology with particular hsps. One instance is the homology between a peptide of mycobacterial Hsp65 and the myelin protein CNP. Our data on EAE suggest that immune responses to either cross-reactive hsp epitopes or whole hsp can modify the course of both acute and chronic relapsing EAE. In addition, the severity and frequency of environmental exposure to infectious agents can modify the course of EAE, possibly by altering the patterns of immune response to hsp. Finally, tolerance to the small hsp, alpha B-crystallin, a putative autoantigen in persons with MS, alters the course of relapsing EAE, supporting its role in chronic, autoimmune CNS disease. Modifying immune responses to hsp may be a potential new treatment option for persons with MS. (+info)Antibody prevents virus reactivation within the central nervous system. (4/278)
The neurotropic JHM strain of mouse hepatitis virus (JHMV) produces an acute CNS infection characterized by encephalomyelitis and demyelination. The immune response cannot completely eliminate virus, resulting in persistence associated with chronic ongoing CNS demyelination. The contribution of humoral immunity to viral clearance and persistent infection was investigated in mice homozygous for disruption of the Ig mu gene (IgM-/-). Acute disease developed with equal kinetics and severity in IgM-/- and syngeneic C57BL/6 (wt) mice. However, clinical disease progressed in IgM-/- mice, while wt mice recovered. Viral clearance during acute infection was similar in both groups, supporting a primary role of cell-mediated immunity in viral clearance. In contrast to wt mice, in which infectious virus was reduced to below detection following acute infection, increasing infectious virus was recovered from the CNS of the IgM-/- mice following initial clearance. No evidence was obtained for selection of variant viruses nor was there an apparent loss of cell-mediated immunity in the absence of Ab. Passive transfer of anti-JHMV Ab following initial clearance prevented reactivation of infectious virus within the CNS of IgM-/- mice. These data demonstrate the clearance of infectious virus during acute disease by cell-mediated immunity. However, immunologic control is not maintained in the absence of anti-viral Ab, resulting in recrudescence of infectious virus. These data suggest that humoral immunity plays no role in controlling virus during acute infection, but plays an important role in establishing and maintaining CNS viral persistence. (+info)Pigs with highly prevalent antibodies to human coronavirus and swine haemagglutinating encephalomyelitis virus in the Tohoku District of Japan. (5/278)
From 1985 to 1988, a total of 2496 swine sera from 60 farms in the Tohoku District of the Honshu Island of Japan were examined for antibodies to swine haemagglutinating encephalomyelitis virus (HEV), human coronavirus (HCV) and bovine coronavirus (BCV) by haemagglutination-inhibition (HI) test. Antibodies to HEV 67N strain and HCV OC43 strain were highly prevalent with positivity rates of 82.1 and 91.4%, respectively, while seropositivity rate to BCV Kakegawa strain was 44.2%. No clinical signs of HEV infection were noticed in any farms including farms with relatively high seropositivity. The results suggested that HCV or antigenitically related virus(es) as well as HEV might be perpetuated in swine in the Tohoku District. (+info)The clinical and epidemiological profile of tick-borne encephalitis in southern Germany 1994-98: a prospective study of 656 patients. (6/278)
Seven hundred and nine patients fell ill in southern Germany (Baden-Wurttemberg) after infection with the tick-borne encephalitis (TBE) virus between 1994 and 1998. Detailed clinical and epidemiological data on TBE were available for 656 patients. A biphasic course of the disease occurred in 485 patients (74%). TBE presented as meningitis in 320 patients (49%), as meningoencephalitis in 270 (41%) and as meningoencephalomyelitis in 66 (10%). Eight of the patients (1.2%) died from TBE. Four hundred and forty-five patients (68%) had noticed a tick bite and the first symptoms occurred, on average, 7 days later. The most frequent neurological symptoms were impairment of consciousness (31%), ataxia (18%) and paresis of the extremities (15%) and cranial nerves (11%). Laboratory investigations revealed leucocytosis in the peripheral blood in 224 out of 392 patients (74%), elevation of the erythrocyte sedimentation rate in 223 out of 245 (91%), increased C-reactive protein in 127 out of 155 (82%), pleocytosis in the CSF of all patients tested, damage of the blood-CSF barrier in 255 out of 322 (79%), abnormalities in EEG in 165 out of 214 (77%) and abnormalities in MRI in 18 out of 102 (18%). In general, adolescents up to 14 years of age had a more favourable course of the disease than adults. Of 230 patients who were re-examined at a later time, 53 (23%) had moderate or severe sequelae. Patients with sequelae presented more frequently (P < 0.001) with impaired consciousness (Glasgow Coma Scale < 7), ataxia, pareses of the extremities or cranial nerves, a need for assisted ventilation, abnormal findings in MRI, pleocytosis > 300 cells/microl and impairment of the blood-CSF barrier (total protein > 600 mg/l). In view of the severity of the illness and the high frequency of sequelae, active immunization against TBE is recommended for all subjects living in and travelling to areas of risk. Prevention of TBE by post-exposure prophylaxis with hyperimmunoglobulins is less effective and therefore should be performed only when absolutely necessary. (+info)MR imaging findings of enteroviral encephaloymelitis: an outbreak in Taiwan. (7/278)
BACKGROUND AND PURPOSE: An outbreak of enterovirus infection occurred in Taiwan from late spring to early fall of 1998. Most of the pediatric infections presented as hand-foot-mouth disease (HFMD) and herpangina. A small portion of patients had symptoms of polio-like encephalitis and paralysis. The purpose of this study was to review the MR imaging findings in CNS involvement of enterovirus infection. METHODS: Twenty patients who had HFMD and clinical encephalitis were examined with MR imaging. T1-weighted and T2-weighted MR images were obtained. From the rectum, throat, CSF, and peripheral blood, the presence of enterovirus 71 (EV 71) was determined by virus culture, immunofluorescent microscopy, immunologic dot blotting, and reverse-transcription polymerase chain reaction. RESULTS: MR imaging studies of 20 patients showed hyperintensity in the brain stem and spinal cord in 15 patients, as seen on T2-weighted images. The major CNS lesions were in the medulla oblongata, pons, midbrain, and the dentate nuclei of the cerebellum. In some cases, the lesions involved the spinal cord (three cases) as well as the thalamus (two cases) and putamina (one case). Five patients had normal MR imaging results. After the appropriate management for tachycardia and tachypnea, 18 patients recovered within 1 to 2 weeks. In the follow-up MR imaging examination of five patients, the lesions completely disappeared within 2 weeks to 2 months. In two patients who were still respirator-dependent, MR imaging showed the tissue destruction in the posterior portions of the medulla, pons, and the ventral horns of cervical spinal cord. In one patient, most of midbrain was damaged. The presence of EV 71 was detected in specimens from 18 patients. CONCLUSION: Because EV 71 was identified in 18 patients, and no other virus was detected, EV 71 was determined to be the major causative agent of this encephalomyelitis. Brain stem and cervical spinal cord involvement are characteristic findings of enteroviral encephalomyelitis. (+info)A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination. (8/278)
Infection of C57BL/6 mice with mouse hepatitis virus (MHV) results in a demyelinating encephalomyelitis characterized by mononuclear cell infiltration and white matter destruction similar to the pathology of the human demyelinating disease multiple sclerosis. The contributions of CD4(+) and CD8(+) T cells in the pathogenesis of the disease were investigated. Significantly less severe inflammation and demyelination were observed in CD4(-/-) mice than in CD8(-/-) and C57BL/6 mice (P < or = 0.002 and P < or = 0.001, respectively). Immunophenotyping of central nervous system (CNS) infiltrates revealed that CD4(-/-) mice had a significant reduction in numbers of activated macrophages/microglial cells in the brain compared to the numbers in CD8(-/-) and C57BL/6 mice, indicating a role for these cells in myelin destruction. Furthermore, CD4(-/-) mice displayed lower levels of RANTES (a C-C chemokine) mRNA transcripts and protein, suggesting a role for this molecule in the pathogenesis of MHV-induced neurologic disease. Administration of RANTES antisera to MHV-infected C57BL/6 mice resulted in a significant reduction in macrophage infiltration and demyelination (P < or = 0.001) compared to those in control mice. These data indicate that CD4(+) T cells have a pivotal role in accelerating CNS inflammation and demyelination within infected mice, possibly by regulating RANTES expression, which in turn coordinates the trafficking of macrophages into the CNS, leading to myelin destruction. (+info)
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Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations
JCI -
Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations
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Chronic fatigue syndrome
"Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Retrieved 25 September 2017.. *^ a b Green, Carmen R.; Cowan, Penney; Elk ... "Treatment , Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". www.cdc.gov. 30 May 2017. Retrieved 12 July 2017.. ... "Symptoms Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". www.cdc.gov. 14 July 2017. Retrieved 19 October 2017.. ... Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. National Academies Press. pp. 148-151. ISBN ...
Mengovirus
Dick, G.W.A.; Haddow, A.J.; Best, A.M.; Smithburn, K.C. (1948). "MENGO ENCEPHALOMYELITIS". The Lancet. 252 (6521): 286-289. doi ... Dick, G. W.; Smithburn, K. C.; Haddow, A. J. (948). "Mengo Encephalomyelitis Virus. Isolation and Immunological Properties". Br ...
Picornavirus
8 February 2005). "Porcine Enteroviral Encephalomyelitis". The Merck Veterinary Manual (9th ed.). Merck. ISBN 978-0-911910-50-6 ...
History of chronic fatigue syndrome
ISBN 0-906923-96-4. "An outbreak of encephalomyelitis in the Royal Free Hospital Group, London, in 1955". Br Med J. 2 (5050): ... Since its introduction into the eighth edition of the WHO ICD-8 in 1969 (code 323), (Benign) myalgic encephalomyelitis has been ... A 1955 outbreak at the Royal Free Hospital Group was later called "Royal Free disease" or "benign myalgic encephalomyelitis". ... In 1978 a symposium held at the Royal Society of Medicine (RSM) concluded that "epidemic myalgic encephalomyelitis" was a ...
Controversies related to chronic fatigue syndrome
The benefit is available to people with myalgic encephalomyelitis (which can have a physical basis or a psychological basis, or ... In 1978 a symposium held at the Royal Society of Medicine (RSM) concluded that epidemic myalgic encephalomyelitis was a ... A 2006 report by the UK Parliamentary Group on Scientific Research into Myalgic Encephalomyelitis stated that: "CFS/ME is ... Vink M, Vink-Niese A (8 October 2018). "Graded exercise therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not ...
Teschovirus
"Overview of Teschovirus Encephalomyelitis". The Merck Veterinary Manual. Merck Manuals. "Viral Zone". ExPASy. Retrieved 15 June ... a severe and fatal form of pig encephalomyelitis), which itself was named for the town in the Czech Republic where the disease ... which is responsible for the porcine enteroviral encephalomyelitis disease caused in pigs. The genus name comes from its type ...
Sheng Tongsheng
Meantime, Sheng overcame the rigours of research during the war, finished the paper "Virus Encephalomyelitis in Buffaloes" ( ... "盛彤笙". The archives of Nanjing Agricultural University (in Chinese). "Virus Encephalomyelitis in Buffaloes". Science.. ...
Augusto, Michaela, and Lorenzo Odone
Siemerling E, Creutzfeldt HG (1923). "Bronzekrankheit und sklerosierende Encephalomyelitis". Arch. Psychiat. Neurokrankh. 68 (1 ...
Betacoronavirus 1
Porcine hemagglutinating encephalomyelitis virus; Equine coronavirus) and a newly recognized virus of dogs (canine respiratory ...
Rosamund Vallings
June 2017: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer. April 2017: ... In 2011, Dr Vallings was one of the authors of the case definition for the Myalgic Encephalomyelitis International Consensus ... August 2011: Myalgic encephalomyelitis: International Consensus Criteria. "International ME/CFS conference airs exciting ... October 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327-38. ...
James Purdon Martin
Martin, J. P. (May 1933). "Acute Benign Myelitis (Encephalo-myelitis)". Proc R Soc Med. 26 (7): 843-844. doi:10.1177/ ...
René Panthier
Meningo-encephalomyelitis of the horse]. Ann Inst Pasteur (Paris) (in French). 118 (2): 239-247. PMID 5461277. Institut Pasteur ...
Post-exertional malaise
"Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Key Facts" (PDF). nap.edu. 2015. p. 2. "IOM 2015 Diagnostic ... "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Symptoms". Centers for Disease Control and Prevention. U.S. ... Post-exertional malaise (PEM) is one of the main symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). PEM ... National Academy of Medicine (Institutes of Medicine). p. 7. "Symptoms of ME/CFS , Myalgic Encephalomyelitis/Chronic Fatigue ...
Meningoencephalitis
"Overview of Meningitis, Encephalitis, and Encephalomyelitis". Merck Manual: Veterinary Manual. Merck Sharp & Dohme Corp. ...
Andrea Prader
"Bronzekrankheit und sklerosierende Encephalomyelitis (diffuse Sklerose)". Archiv für Psychiatrie. 68: 217-44. doi:10.1007/ ...
McDonald criteria
"Acute disseminated encephalomyelitis and multiple sclerosis". Brain. 133 (Pt 2): 317-319. doi:10.1093/brain/awp342. PMID ...
Maureen Hanson
Due to personal interest in the disease, in 2009 Hanson initiated an additional research program on Myalgic Encephalomyelitis/ ... Hanson, Maureen R.; Giloteaux, Ludovic (2017-04-01). "The gut microbiome in Myalgic Encephalomyelitis". The Biochemist. 39 (2 ... and the molecular basis of the disease Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Hanson grew up in the ... "Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations". ...
Multiple sclerosis research
2015). "Histopathology and clinical course of MOG-antibody-associated encephalomyelitis". Annals of Clinical and Translational ... antiMOG associated encephalomyelitis and a third one was separated as anti-neurofascin disease. This research is not closed and ... acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort ... and some tumefactive cases of MS as anti-MOG associated encephalomyelitis. Some researchers think that there could exist also ...
Pathology of multiple sclerosis
These glial scars are the remnants of previous demyelinating inflammatory lesions (encephalomyelitis disseminata) which are ... 2015). "Histopathology and clinical course of MOG-antibody-associated encephalomyelitis". Annals of Clinical and Translational ... Lassmann H (2010). "Acute disseminated encephalomyelitis and multiple sclerosis". Brain. 133 (2): 317-319. doi:10.1093/brain/ ... AntiMOG associated encephalomyelitis. High levels of anti-nuclear antibodies are found normally in patients with MS[citation ...
TNF inhibitor
"Acute disseminated encephalomyelitis and multiple sclerosis". Brain. 133 (2): 317-319. doi:10.1093/brain/awp342. PMID 20129937 ...
Chikungunya
Arbovirus encephalitides: Eastern equine encephalomyelitis *EEEV. *Western equine encephalomyelitis *WEEV. *Venezuelan equine ...
Ebola virus disease
Arbovirus encephalitides: Eastern equine encephalomyelitis *EEEV. *Western equine encephalomyelitis *WEEV. *Venezuelan equine ...
Semliki Forest virus
Arbovirus encephalitides: Eastern equine encephalomyelitis *EEEV. *Western equine encephalomyelitis *WEEV. *Venezuelan equine ...
Jennifer Brea
"Myalgic Encephalomyelitis / Chronic Fatigue Syndrome Protests Tuesday". National Pain Report. 2016-09-27. Retrieved 2016-12-17 ... "The Beachwood Reporter - Chicago Residents To Protest Lack Of Support For Those Suffering With Myalgic Encephalomyelitis/ ... She was initially misdiagnosed with conversion disorder, but eventually was identified as having myalgic encephalomyelitis (ME ... "Housebound versus nonhousebound patients with myalgic encephalomyelitis and chronic fatigue syndrome". Chronic Illness. 12 (4 ...
Edelfosine
Klein-Franke, A; Munder PG (1992). "Alkyllysophospholipid prevents induction of experimental allergic encephalomyelitis". ...
Akureyri disease
Chronic fatigue syndrome Blattner R (1956). "Benign myalgic encephalomyelitis (Akureyri disease, Iceland disease)". J. Pediatr ...
CCL1
Godiska R, Chantry D, Dietsch GN, Gray PW (May 1995). "Chemokine expression in murine experimental allergic encephalomyelitis ... CCL1 and CCR8 mRNA expression has been detected in the CNS of mice with experimental autoimmune encephalomyelitis (EAE). ...
Melanie Greter
"Experimental autoimmune encephalomyelitis repressed by microglial paralysis". Nature Medicine. 11 (2): 146-152. doi:10.1038/ ... the development and maintenance of inflammation in the central nervous system in experimental autoimmune encephalomyelitis. ...
Ken Trevallion
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Society "Deaths". The Sydney Morning Herald. Sydney. 12 September 2009. " ... was an Australian known for his work with We Help Ourselves drug rehabilitation centres and the Myalgic Encephalomyelitis and ... For service to the community through We Help Ourselves and the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Society of ...
Diagnosis of ME/CFS | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | CDC
Possible Causes | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | CDC
Frontiers | Unperturbed Cytotoxic Lymphocyte Phenotype and Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome...
Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a debilitating disorder linked to diverse intracellular ... Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a debilitating disorder linked to diverse intracellular ... Myalgic encephalomyelitis/chronic fatigue syndrome. J Chronic Fatigue Syndr (2003) 11(1):7-115. doi:10.1300/J092v11n01_02 ... Myalgic encephalomyelitis: international consensus criteria. J Intern Med (2011) 270(4):327-38. doi:10.1111/j.1365-2796.2011. ...
EXPERIMENTAL ENCEPHALOMYELITIS | The BMJ
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ArboCat Virus: Eastern equine encephalomyelitis (EEEV)
What causes acute disseminated encephalomyelitis (ADEM)?
How is diagnosis of acute disseminated encephalomyelitis (ADEM) confirmed?. *How is acute disseminated encephalomyelitis (ADEM ... "Treatments for Acute Disseminated Encephalomyelitis (ADEM) in Children," "Acute disseminated encephalomyelitis (ADEM) symptoms ... "Treatments for Acute Disseminated Encephalomyelitis (ADEM) in Children," "Acute disseminated encephalomyelitis (ADEM) symptoms ... What causes acute disseminated encephalomyelitis (ADEM)?. ANSWER ADEM seems to be an autoimmune disease. That means your immune ...
Acute Disseminated Encephalomyelitis Differential Diagnoses
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory demyelinating condition that predominately ... Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain. ... Acute disseminated encephalomyelitis: a riddle wrapped in a mystery inside an enigma. Int J Clin Pract. 2003 Apr. 57(3):235-7. ... Acute Disseminated Encephalomyelitis Differential Diagnoses. Updated: Dec 05, 2017 * Author: J Nicholas Brenton, MD; Chief ...
Encephalomyelitis - Wikipedia
Various types of encephalomyelitis include: Acute disseminated encephalomyelitis or postinfectious encephalomyelitis, a ... Acute disseminated encephalomyelitis at NIHs Office of Rare Diseases Acute Disseminated Encephalomyelitis Information Page at ... Encephalomyelitis disseminata, a synonym for multiple sclerosis. AntiMOG associated encephalomyelitis, one of the underlying ... Experimental autoimmune encephalomyelitis (EAE), an animal model of brain inflammation. Progressive encephalomyelitis with ...
Chronic Fatigue Syndrome Versus Myalgic Encephalomyelitis | Psychology Today
Many dislike the label "CFS," and in other countries it is referred to as myalgic encephalomyelitis (ME). Actually, the 2003 ... Chronic Fatigue Syndrome Versus Myalgic Encephalomyelitis. What are words for? Posted Feb 01, 2015 ... The Institute of Medicines Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome will ...
Acute Disseminated Encephalomyelitis in Children | ELECTRONIC ARTICLE | Pediatrics
encephalomyelitis. Acute disseminated encephalomyelitis (ADEM) is considered a monophasic acute demyelinating disorder of the ... Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain.2000 ... Acute Disseminated Encephalomyelitis in Children. S. N. Krishna Murthy, Howard S. Faden, Michael E. Cohen, Rohit Bakshi ... ADEM, acute disseminated encephalomyelitis, CNS, central nervous system, MRI, magnetic resonance imaging, FLAIR, fluid- ...
Acute Disseminated Encephalomyelitis in Children | ELECTRONIC ARTICLE | Pediatrics
Acute Disseminated Encephalomyelitis: Background, Pathophysiology, Epidemiology
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory demyelinating condition that predominately ... Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain. ... encoded search term (Acute Disseminated Encephalomyelitis) and Acute Disseminated Encephalomyelitis What to Read Next on ... Acute Disseminated Encephalomyelitis. Updated: Nov 08, 2018 * Author: J Nicholas Brenton, MD; Chief Editor: Tarakad S ...
Acute Disseminated Encephalomyelitis (ADEM)
... is a rare autoimmune disease that damages the covering of central nervous system ... Acute Disseminated Encephalomyelitis (ADEM). Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune disease, which ... What are the signs and symptoms of Acute Disseminated Encephalomyelitis (ADEM)?. Symptoms of ADEM can range, depending on the ... What is Acute Disseminated Encephalomyelitis (ADEM)?. The central nervous system - the brain, optic nerves and spinal cord - is ...
Equine encephalomyelitis - Wikipedia
How is acute disseminated encephalomyelitis (ADEM) diagnosed in kids?
acute disseminated encephalomyelitis (adem) and multiple sclerosis (ms) have similar symptoms, but ms is rare in children. ... How is acute disseminated encephalomyelitis (ADEM) diagnosed in kids?. ANSWER Acute disseminated encephalomyelitis (ADEM) and ... "Treatments for Acute Disseminated Encephalomyelitis (ADEM) in Children," "Acute disseminated encephalomyelitis (ADEM) symptoms ... "Treatments for Acute Disseminated Encephalomyelitis (ADEM) in Children," "Acute disseminated encephalomyelitis (ADEM) symptoms ...
Encephalomyelitis in primary hypogammaglo... & related info | Mendeley
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Avian encephalomyelitis virus - PCR | Animal Health Laboratory
A Rare Sequela of Acute Disseminated Encephalomyelitis
G. Alper, "Acute disseminated encephalomyelitis," Journal of Child Neurology, vol. 27, no. 11, pp. 1408-1425, 2012. View at ... A Rare Sequela of Acute Disseminated Encephalomyelitis. Vijay Kodadhala,1 Saravana Devulapalli,2 Mohankumar Kurukumbi,2 and ... Acute disseminated encephalomyelitis (ADEM) which is commonly preceded by an infection is an inflammatory and demyelinating ... Acute disseminated encephalomyelitis is a demyelinating disease, typically occurring in children following a febrile infection ...
TOXOPLASMIC ENCEPHALOMYELITIS | JEM
Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS): MedlinePlus Medical Encyclopedia
Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a long-term illness that affects many body systems. People ... Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a long-term illness that affects many body systems. People ... Myalgic encephalomyelitis/chronic fatigue syndrome: treatment. www.cdc.gov/me-cfs/treatment/index.html. Updated November 19, ... Treatment of myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review for a National Institutes of Health ...
Modulation of experimental autoimmune encephalomyelitis through c...: Ingenta Connect
Acute Disseminated Encephalomyelitis and Other Acute Parainfectious Syndromes | SpringerLink
Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory, demyelinating disorder of the CNS, now recognized as a ... Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain. ... Acute disseminated encephalomyelitis: prognostic value of early follow-up brain MRI. J Neurol. 2017;264:1754-62.CrossRefPubMed ... Acute disseminated encephalomyelitis: an update. Arch Neurol. 2005;62:1673-80.CrossRefPubMedGoogle Scholar ...
Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics | Scientific...
The pathogenesis of ME/CFS, a disease characterized by fatigue, cognitive dysfunction, sleep disturbances, orthostatic intolerance, fever, irritable bowel syndrome (IBS), and lymphadenopathy, is poorly understood. We report biomarker discovery and topological analysis of plasma metabolomic, fecal bacterial metagenomic, and clinical data from 50 ME/CFS patients and 50 healthy controls. We confirm reports of altered plasma levels of choline, carnitine and complex lipid metabolites and demonstrate that patients with ME/CFS and IBS have increased plasma levels of ceramide. Integration of fecal metagenomic and plasma metabolomic data resulted in a stronger predictive model of ME/CFS (cross-validated AUC = 0.836) than either metagenomic (cross-validated AUC = 0.745) or metabolomic (cross-validated AUC = 0.820) analysis alone. Our findings may provide insights into the pathogenesis of ME/CFS and its subtypes and suggest pathways for the development of diagnostic and therapeutic strategies.
Regulatory T cells in spontaneous autoimmune encephalomyelitis
Spontaneous experimental autoimmune encephalomyelitis (EAE) develops in 100% of mice harboring a monoclonal myelin basic ... Regulatory T cells in spontaneous autoimmune encephalomyelitis Immunol Rev. 2001 Aug;182:122-34. doi: 10.1034/j.1600-065x. ... Spontaneous experimental autoimmune encephalomyelitis (EAE) develops in 100% of mice harboring a monoclonal myelin basic ...
Encephalomyelitis | GreenMedInfo | Disease | Natural Medicine
Diseases : Encephalomyelitis, Neurological Damage, Vaccine-induced Toxicity Anti Therapeutic Actions : Vaccination: All, ... Diseases : Encephalomyelitis, Multiple Sclerosis, Oxidative Stress. Pharmacological Actions : Anti-Inflammatory Agents, ... Diseases : Encephalomyelitis, Multiple Sclerosis. Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, ... Diseases : Encephalomyelitis. Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, STAT3 ...
Avian encephalomyelitis/encephalitis | BackYard Chickens
Avian encephalomyelitis/encephalitis Discussion in Emergencies / Diseases / Injuries and Cures started by Evets70, Sep 10, ... Avian encephalomyelitis/encephalitis doesnt affect chicks until at least one week of age, so something like this disease ... At day 4, one of them turned up with AE, Avian Encephalomyelitis. Fortunately I was able to save her, but not before she ... any problems trying to obtain a refund or credit from a hatchery due to the loss of baby chicks from Avian encephalomyelitis/ ...
Myalgic Encephalomyelitis ("Chronic Fatigue Syndrome")
Myalgic Encephalomyelitis (Chronic Fatigue Syndrome) Myalgic Encephalomyelitis (ME), commonly referred to as chronic fatigue ... Myalgic Encephalomyelitis (my*al*gic + en*ceph*a*lo*my*eli*tis) (ME), commonly referred to as chronic fatigue syndrome, is a ... Trans-NIH Myalgic Encephalomyelitis / Chronic Fatigue Syndrome Working Group. Research Centers. *Center for Solutions for ... You are Here: Home Page , Diseases & Conditions , Myalgic Encephalomyelitis (Chronic Fatigue Syndrome) ...
Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor | PNAS
The influence of laquinimod on the immune system was studied in experimental autoimmune encephalomyelitis (EAE) (4⇓⇓⇓⇓⇓⇓⇓-12), ... Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor Message Subject (Your ... Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor. Joel Kaye, Victor ... 2013) Laquinimod prevents inflammation-induced synaptic alterations occurring in experimental autoimmune encephalomyelitis. ...
MyalgicADEMChronicMultiple sclerosisDiagnosisAvianEquine Encephalomyelitis VirusWestern equine encephalomyelitisEastern equine encephalomyelitisNINDS Acute Disseminated Encephalomyelitis InfLocked-in syndrAutoimmuneCase of acute disseminated enceTherapy in acute disseminated enceChildren with acute disseminated encePatients with acute disseminated enceInfectionAcute disseminatedDiseasesHemagglutinating encephalomyelitis virusEncephalitisVaccineTypes of encephalomyelitisGranulomatous encephalomyelitisMiceDiseaseBenignVirusesInflammation of the brainClinicalSpinal cordRigidityMeSHPlasmapheresisNeurologicVaccination
Myalgic48
- Scientists have not yet identified what causes myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (cdc.gov)
- Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a debilitating disorder linked to diverse intracellular infections as well as physiological stress. (frontiersin.org)
- Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a heterogeneous disorder of unknown etiology. (frontiersin.org)
- ME, or Myalgic Encephalomyelitis , is classified as a disease of the nervous system by the World Health Organisation . (bbc.co.uk)
- Many dislike the label "CFS," and in other countries it is referred to as myalgic encephalomyelitis (ME). (psychologytoday.com)
- The Institute of Medicine's Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome will hold a public release event for its consensus report on February 10th, 2015 from 11:00 am-12:00 pm EST at the Keck Center of the National Academies in Washington, D.C. (500 Fifth Street NW, Washington, DC). (psychologytoday.com)
- Myalgic Encephalomyelitis (ME) continues to cause significant morbidity worldwide with an estimated one million cases in the United States. (ingentaconnect.com)
- Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a long-term illness that affects many body systems. (medlineplus.gov)
- Myalgic Encephalomyelitis (ME), commonly referred to as chronic fatigue syndrome or ME/CFS, is a widely misunderstood disease. (ny.gov)
- Myalgic Encephalomyelitis (my*al*gic + en*ceph*a*lo*my*eli*tis) (ME), commonly referred to as chronic fatigue syndrome, is a serious, debilitating, chronic disease that affects multiple body systems, including the nervous system, the immune system, and the body's production of energy. (ny.gov)
- At Stanford, we believe that a subset of cases of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) may be related to infection. (stanford.edu)
- The AHRQ evidence report on the Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome was published in December, 2014 and provided a literature review for the National Institutes of Health Pathways to Prevention Workshop on Advancing the Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. (nih.gov)
- 1 , 2 The review found eight case definitions for either chronic fatigue syndrome (CFS), myalgic encephalomyelitis (ME), or ME/CFS, and since its publication, an additional case definition was published by the Institute of Medicine along with the recommendation of a new name, Systemic Exertional Intolerance Disease. (nih.gov)
- To experimentally assess visual attention difficulties commonly reported by those with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (prohealth.com)
- Nutritional supplements are an essential component of any Chronic Fatigue Syndrome & Myalgic Encephalomyelitis (ME/CFS) treatment protocol. (prohealth.com)
- Even in the absence of clinical nutritional deficiencies, the physiological demands of a chronic illness make it necessary to provide additional nutritional support - especially in light of the numerous GI problems prevalent in the Chronic Fatigue Syndrome & Myalgic Encephalomyelitis population, which may lead to malabsorption. (prohealth.com)
- Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease which afflicts approximately 2 million people in the United States and many more around the globe. (pnas.org)
- There is not currently a well-established, if any, biological test to diagnose myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (pnas.org)
- Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease that affects at least 2 million Americans and millions more globally ( 1 ⇓ - 3 ). (pnas.org)
- Between 836,000 and 2.5 million Americans suffer from myalgic encephalomyelitis/chronic fatigue syndrome-commonly referred to as ME/ CFS. (nationalacademies.org)
- The Food and Drug Administration (FDA), Center for Drug Evaluation and Research, is announcing a public workshop to discuss how best to facilitate and expedite the development of safe and effective drug therapies to treat signs and symptoms related to chronic fatigue syndrome (CFS) and myalgic encephalomyelitis (ME). (federalregister.gov)
- This guideline covers diagnosing and managing chronic fatigue syndrome (CFS) which is also known as myalgic encephalomyelitis (ME) (or encephalopathy). (nice.org.uk)
- There are approximately 250,000 people diagnosed with Myalgic Encephalomyelitis (ME) in the UK. (positivehealth.com)
- Virtually no other medical disorder has been referred to by so many different names, some of which include Chronic Fatigue Syndrome (CFS), Myalgic Encephalomyelitis, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS), Neurasthenia, Post Viral Fatigue Syndrome (PVFS), and most recently, Systemic Exertion Intolerance Disease (SEID). (positivehealth.com)
- Last year in the US, the National Institutes of Health's (NIH) Pathways To Prevention (P2P) program published a report titled Advancing the Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome . (positivehealth.com)
- In February 2015, the IOM published a report, Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness which proposed several positive changes, including a new name - Systemic Exertion Intolerance Disease (SEID) - and with that, a new set of diagnostic criteria. (positivehealth.com)
- Two techniques can help you manage your energy when you have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (cigna.com)
- Intracellular immune dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: state of the art and therapeutic implications. (ei-resource.org)
- Evidence in support of intracellular immune dysfunctions in people with myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is accumulating, but few studies have addressed intracellular immunity as a potential therapeutic target. (ei-resource.org)
- Is Chronic Fatigue Syndrome / Myalgic Encephalomyelitis a Relevant Diagnosis in Patients with Suspected Side Effects to Human Papilloma Virus Vaccine? (sanevax.org)
- As fatigue and fatigability is a prominent symptom in many of the patients with suspected side effects to the vaccine, chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)c ould be suspected to be a suitable diagnosis. (sanevax.org)
- Myalgic encephalomyelitis/chronic fatigue syndrome affects an estimated 836,000 to 2.5 million adults in the U.S. with a constellation of debilitating symptoms, including severe fatigue, pain, sleep disturbances, and cognitive problems. (nurse.com)
- The goal of this continuing education module is to provide an overview of myalgic encephalomyelitis/chronic fatigue syndrome, a complex multisymptom disorder. (nurse.com)
- Myalgic encephalomyelitis ("ME") affects approximately 1 in 400 and four times as many women as men. (wpinstitute.org)
- How is myalgic encephalomyelitis treated? (wpinstitute.org)
- The National Institutes of Health (NIH) will award four grants to establish a coordinated scientific research effort on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (nih.gov)
- Assessment of Exercise Response in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis. (clinicaltrials.gov)
- Chronic fatigue syndrome/ myalgic encephalomyelitis presents with a significant deterioration of functional capacity, which seriously affects the quality of life. (clinicaltrials.gov)
- Post-Infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (PI-ME/CFS) refers to long-lasting and disabling fatigue or malaise, inability to recover after exercise, and physical and emotional discomfort that may occur after a person has an infection. (clinicaltrials.gov)
- As noted in Chapter 1 , "ME/CFS" is an umbrella term that includes myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS). (nap.edu)
- The term "benign myalgic encephalomyelitis" was first used in the 1950s to describe a similar outbreak at the Royal Free Hospital in London (Wojcik et al. (nap.edu)
- Although the cause of the condition could not be determined, it appeared to be infectious, and the term "benign myalgic encephalomyelitis" eventually was chosen to reflect "the absent mortality, the severe muscular pains, the evidence of parenchymal damage to the nervous system, and the presumed inflammatory nature of the disorder" (Acheson, 1959, p. 593). (nap.edu)
- In 1970, two psychiatrists in the United Kingdom reviewed the reports of 15 outbreaks of benign myalgic encephalomyelitis and concluded that these outbreaks "were psychosocial phenomena caused by one of two mechanisms, either mass hysteria on the part of the patients or altered medical perception of the community" (McEvedy and Beard, 1970, p. 11). (nap.edu)
- People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) report vision-related reading difficulty, although this has not been demonstrated objectively. (meresearch.org.uk)
- Myalgic encephalomyelitis--a persistent enteroviral infection? (bmj.com)
- Myalgic encephalomyelitis is a common disability but frequently misinterpreted. (bmj.com)
- Child and adolescent chronic fatigue syndrome/myalgic encephalomyelitis: where are we now? (medworm.com)
- Purpose of review The current review aims to determine the recent evidence regarding cause, impact, effective treatment and prognosis of children and young people (CYP) affected by chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) at a time when the National Institute for Clinical Excellence guidelines in the United Kingdom are being reviewed and more research is called for worldwide. (medworm.com)
ADEM29
- What causes acute disseminated encephalomyelitis (ADEM)? (webmd.com)
- National Multiple Sclerosis Society: "Acute Disseminated Encephalomyelitis (ADEM). (webmd.com)
- Children's Healthcare of Atlanta: "Acute Disseminated Encephalomyelitis (ADEM): Patient and Family Education. (webmd.com)
- Boston Children's Hospital: "Acute Disseminated Encephalomyelitis (ADEM) Testing and Diagnosis," "Pediatric Multiple Sclerosis And Related Disorders Program at Boston Children's Hospital," "Treatments for Acute Disseminated Encephalomyelitis (ADEM) in Children," "Acute disseminated encephalomyelitis (ADEM) symptoms & causes in children. (webmd.com)
- What are the symptoms of acute disseminated encephalomyelitis (ADEM)? (webmd.com)
- Chowdhary J, Ashraf SM, Khajuria K. Measles with acute disseminated encephalomyelitis (ADEM). (medscape.com)
- and outcome in a cohort of children with acute disseminated encephalomyelitis (ADEM). (aappublications.org)
- Acute disseminated encephalomyelitis (ADEM) is considered a monophasic acute demyelinating disorder of the central nervous system (CNS) characterized by diffuse neurologic signs and symptoms coupled with evidence of multifocal lesions of demyelination on neuroimaging. (aappublications.org)
- The inpatient database of Children's Hospital of Buffalo was broadly searched for patients with the diagnosis of ADEM, viral encephalitis, postinfectious encephalitis, encephalomyelitis, and transverse myelitis. (aappublications.org)
- Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory demyelinating condition that predominately affects the white matter of the brain and spinal cord. (medscape.com)
- Multiple sclerosis (MS) and acute disseminated encephalomyelitis (ADEM) bear a close pathological resemblance, each resembling the pathology of experimental allergic encephalomyelitis (EAE). (medscape.com)
- Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune disease, which causes inflammation (swelling) and damage to the protective covering of the fibers in the central nervous system. (childrens.com)
- How is acute disseminated encephalomyelitis (ADEM) diagnosed in kids? (webmd.com)
- Acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) have similar symptoms, but MS is rare in children. (webmd.com)
- What symptoms of acute disseminated encephalomyelitis (ADEM) are shared with other diseases? (webmd.com)
- What is the goal of treating acute disseminated encephalomyelitis (ADEM)? (webmd.com)
- Acute disseminated encephalomyelitis (ADEM) which is commonly preceded by an infection is an inflammatory and demyelinating disorder of central nervous system [ 1 ]. (hindawi.com)
- Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory, demyelinating disorder of the CNS, now recognized as a distinct entity and not a multiple sclerosis variant. (springer.com)
- Esposito S, Di Pietro GM, Madini B, Mastrolia MV, Rigante D. A spectrum of inflammation and demyelination in acute disseminated encephalomyelitis (ADEM) of children. (springer.com)
- Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin - the protective covering of nerve fibers. (nih.gov)
- Need to make a doctor appointment for Acute Disseminated Encephalomyelitis (ADEM) this week? (zocdoc.com)
- Acute disseminated encephalomyelitis (ADEM) is an inflammatory, usually monophasic, immune mediate, demyelinating disease of the central nervous system which involves the white matter. (greenmedinfo.com)
- Acute disseminated encephalomyelitis (ADEM) involves a brief but intense attack of inflammation (swelling) in the brain and spinal cord that damages the brain's myelin. (childrenshospital.org)
- What is the role of genetics in the etiology of acute disseminated encephalomyelitis (ADEM)? (medscape.com)
- Which conditions should be included in the differential diagnoses of acute disseminated encephalomyelitis (ADEM)? (medscape.com)
- Acute disseminated encephalomyelitis (ADEM) is a disorder in which the immune system causes an intense attack on the brain, and sometimes the spinal cord and the optic nerves. (chop.edu)
- This case fits well in the spectrum of acute disseminated encephalomyelitis (ADEM), an inflammatory demyelinating disease of the central nervous systems of children and young adults, which occur in close temporal relationship with several infectious illnesses and immunizations ( 2 - 6 ). (cdc.gov)
- White matter lesions on MR images obtained from patients with acute disseminated encephalomyelitis (ADEM) have been reported to appear shortly after symptom onset, and their resolution has been claimed to parallel recovery. (ajnr.org)
- Acute disseminated encephalomyelitis (ADEM) is a severe, acute, demyelinating disease of the CNS. (ajnr.org)
Chronic3
- Mylagic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling and complex illness. (news-medical.net)
- In Beyond Myal-gic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness, the com-mittee proposes new diagnostic criteria that will facilitate timely diagnosis and care and enhance understanding among health care providers and the public. (nationalacademies.org)
- Mylagic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, highly variable neurodegenerative disease affecting over 2 million Americans. (medindia.net)
Multiple sclerosis10
- Alper G, Heyman R, Wang L. Multiple sclerosis and acute disseminated encephalomyelitis diagnosed in children after long-term follow-up: comparison of presenting features. (medscape.com)
- Encephalomyelitis disseminata, a synonym for multiple sclerosis. (wikipedia.org)
- Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. (springer.com)
- Steroid protection in the experimental autoimmune encephalomyelitis model of multiple sclerosis. (springer.com)
- Experimental autoimmune encephalomyelitis (EAE) is an animal model of the human demyelinating disorder multiple sclerosis (MS). The immune cytokine interferon-gamma (IFN-γ) is believed to participate in disease pathogenesis in both EAE and MS. In the present study, we examined the significance of IFN-γ-oligodendrocyte interactions in the course of EAE. (jneurosci.org)
- Experimental autoimmune encephalomyelitis (EAE) is an animal model of the human demyelinating disorder multiple sclerosis (MS) ( Lassmann and Werkele, 1998 ). (jneurosci.org)
- Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. (tudelft.nl)
- Experimental Autoimmune Encephalomyelitis (EAE) is an experimental model most frequently used for research on demyelinating diseases such as Multiple Sclerosis (MS) and can be used as a model of cell-mediated organ-specific autoimmune conditions in general. (novusbio.com)
- Experimental autoimmune encephalomyelitis (EAE) is a mouse model that reproduces cardinal signs of clinical, histopathological, and immunological features found in Multiple Sclerosis (MS). Mast cells are suggested to be involved in the main inflammatory phases occurring during EAE development, possibly by secreting several autacoids and proteases. (hindawi.com)
- In multiple sclerosis (MS) 3 and its animal model, experimental autoimmune encephalomyelitis (EAE), myelin and oligodendrocytes (OLG) are primary targets of cellular and humoral immune effectors ( 2 ). (jimmunol.org)
Diagnosis2
- Diagnosis of acute disseminated encephalomyelitis is strongly suggested by temporal relationship between an infection or an immunization and the onset of neurological symptoms. (hindawi.com)
- This leaves a "diagnosis" of idiopathic encephalomyelitis (IE). (dogsnaturallymagazine.com)
Avian13
- Has anyone out there had any problems trying to obtain a refund or credit from a hatchery due to the loss of baby chicks from Avian encephalomyelitis/encephalitis? (backyardchickens.com)
- Avian encephalomyelitis/encephalitis doesn't affect chicks until at least one week of age, so something like this disease obviously won't fall within that policy. (backyardchickens.com)
- At day 4, one of them turned up with AE, Avian Encephalomyelitis. (backyardchickens.com)
- Avian encephalomyelitis virus infection in laying bird causes inapparent infection or drops in egg production. (thepoultrysite.com)
- See Avian Encephalomyelitis, Epidemic tremors for its effect in young birds. (thepoultrysite.com)
- Avian encephalomyelitis is a viral infection affecting the CNS of several species of birds. (merckvetmanual.com)
- Avian encephalomyelitis (AE) is a viral disease of the CNS of young chickens, turkeys, Japanese quail, pheasants, and pigeons . (merckvetmanual.com)
- Vertically infected chicks commonly show clinical signs of avian encephalomyelitis during the first week after hatching, although signs may be present in a few birds at hatching. (merckvetmanual.com)
- Do my chicks have Avian Encephalomyelitis virus? (backyardchickens.com)
- One of the other symptoms of Avian encephalomyelitis virus was sitting on the back on the back of its legs. (backyardchickens.com)
- Do you think that my chicks have Avian Encephalomyelitis virus? (backyardchickens.com)
- Avian Encephalomyelitis-Fowl Pox-Pigeon Pox Vaccine is a chicken embryo propagated, freeze-dried, live virus vaccine for wing web administration in chickens. (jefferspet.com)
- When used as indicated, it will aid in preventing the clinical signs caused by the virulent field strains of avian encephalomyelitis and fowl pox viruses. (jefferspet.com)
Equine Encephalomyelitis Virus7
- The pathogenesis of an attenuated and an unattenuated strain of Venezuelan equine encephalomyelitis virus infection in suckling mice as studied by infectivity titrations and direct fluorescent antibody-staining technique was described. (jimmunol.org)
- Diversity within natural populations of eastern equine encephalomyelitis virus. (biomedsearch.com)
- Laboratory transmission of eastern equine encephalomyelitis virus to chickens by chicken mites (Acari: Dermanyssidae). (harvard.edu)
- Infection and transmission of eastern equine encephalomyelitis virus with colonized Culiseta melanura (Coquillett). (thefreedictionary.com)
- Eastern equine encephalomyelitis virus and Western equine encephalomyelitis viruses with known circulation in Argentina were included in the assay with negative results (3). (thefreedictionary.com)
- Eastern equine encephalomyelitis virus (EEEV), Venezuelan equine encephalomyelitis virus (VEEV), and Western equine encephalomyelitis virus (WEEV). (thefreedictionary.com)
- By examining the spatial/temporal infection dynamics of Culex tarsalis strains infected with western equine encephalomyelitis virus (WEEV), we identified tissue tropisms and potential tissue barriers, and evaluated the effects of viral dose and time postingestion. (dovepress.com)
Western equine encephalomyelitis4
- equine encephalomyelitis, eastern a viral disease similar to western equine encephalomyelitis, but occurring in a region extending from New Hampshire to Texas and as far west as Wisconsin, and in Canada, Mexico, the Caribbean, and parts of Central and South America. (thefreedictionary.com)
- Anesthesia, by ether, is effective in the treatment of western equine encephalomyelitis in mice. (sciencemag.org)
- Western equine encephalomyelitis: virulence markers and their epidemiologic significance. (harvard.edu)
- Serum samples were first tested against the major neurotropic viruses infecting horses, including Eastern equine encephalomyelitis , Western equine encephalomyelitis, and Venezuelan equine encephalomyelitis. (thefreedictionary.com)
Eastern equine encephalomyelitis2
- We evaluated genetic and phenotypic diversity within natural populations of the alphavirus, Eastern equine encephalomyelitis (EEE) virus. (biomedsearch.com)
- Eastern equine encephalomyelitis in upstate New York: studies of a 1976 epizootic by a modified serologic technique, hemagglutination reduction, for rapid detection of virus infections. (thefreedictionary.com)
NINDS Acute Disseminated Encephalomyelitis Inf1
- National Institute of Neurological Disorders and Stroke: "NINDS Acute Disseminated Encephalomyelitis Information Page. (webmd.com)
Locked-in syndr2
- Locked-in syndrome is a rare complication of acute disseminated encephalomyelitis. (hindawi.com)
- We present a case of incomplete locked-in syndrome occurring in a 34-year-old male secondary to acute disseminated encephalomyelitis. (hindawi.com)
Autoimmune19
- Experimental autoimmune encephalomyelitis (EAE), an animal model of brain inflammation. (wikipedia.org)
- Modulation of experimental autoimmune encephalomyelitis through c. (ingentaconnect.com)
- Spontaneous experimental autoimmune encephalomyelitis (EAE) develops in 100% of mice harboring a monoclonal myelin basic protein (MBP)-specific CD4+ alphabeta T-cell repertoire. (nih.gov)
- The present work investigates the modulation of experimental autoimmune encephalomyelitis (EAE) using genistein before the EAE induction. (springer.com)
- Touil T, Fitzgerald D, Zhang GX, Rostami A, Gran B. Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta. (springer.com)
- Estrogen receptor α signaling in T lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and protection against experimental autoimmune encephalomyelitis. (springer.com)
- Experimental autoimmune encephalomyelitis (EAE) is the prototypical animal model of MS. Much of what we have learned about the pathophysiology of MS has come from EAE, which has also provided valuable insights into therapeutic approaches that might be effective in MS ( 4 ). (frontiersin.org)
- We describe here a gene expression- and bioinformatics-based study showing that celastrol, a natural triterpenoid, acting via MAPK pathway regulates the downstream genes encoding serum/glucocorticoid regulated kinase 1 (SGK1), which plays a vital role in Th17/Treg differentiation, and brain-derived neurotrophic factor (BDNF), which is a neurotrophic factor, thereby offering protection against experimental autoimmune encephalomyelitis (EAE) in mice. (springer.com)
- In SJL mice lactobacilli are able to enhance or inhibit the development of disease after induction of experimental autoimmune encephalomyelitis (EAE). (tudelft.nl)
- Submit your Twitter account related to Experimental Autoimmune Encephalomyelitis to be featured! (novusbio.com)
- Submit your blog on Experimental Autoimmune Encephalomyelitis to be featured! (novusbio.com)
- Experimental Autoimmune Encephalomyelitis has been used to develop many medications for such diseases. (novusbio.com)
- Autoimmune Encephalomyelitis is an induced autoimmune disorder that creates inflammation in the brain and spinal cord. (novusbio.com)
- Explore more on Experimental Autoimmune Encephalomyelitis below! (novusbio.com)
- We have 3924 products for the study of Experimental Autoimmune Encephalomyelitis that can be applied to Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence from our catalog of antibodies and ELISA kits. (novusbio.com)
- Albeit the mechanisms by which mast cells influence MS are yet to be fully understood, trypsin-like proteases released from degranulating mast cells have been shown to trigger demyelination in a mouse model for MS-experimental autoimmune encephalomyelitis (EAE) [ 9 ]. (hindawi.com)
- Benztropine, a FDA-approved drug used for treatment of Parkinson's disease was recently identified as an effective inducer of oligodendrocyte precursor cell (OPC) differentiation in vitro and in experimental autoimmune encephalomyelitis (EAE), the most common animal model used to study MS. Thus, we sought to study the synergy of benztropine and tuftsin, immunomodulatory tetrapeptide shown to polarize microglia to the M2 phenotype in a MOG-induced acute EAE model. (omicsonline.org)
- We have made an exciting observation that dietary indoles such as DIM can completely suppress the clinical disease in an experimental model of MS known as Experimental Autoimmune Encephalomyelitis (EAE). (labome.org)
- Complement activation is involved in the initiation of Ab-mediated inflammatory demyelination in experimental autoimmune encephalomyelitis (EAE). (jimmunol.org)
Case of acute disseminated ence2
- A case of acute disseminated encephalomyelitis associated with Epstein-Barr virus reactivation during infliximab therapy has been reported. (greenmedinfo.com)
- This report describes a case of acute disseminated encephalomyelitis with severe neurological outcomes following a seasonal influenza vaccine. (greenmedinfo.com)
Therapy in acute disseminated ence1
- Accepted modes of therapy in acute disseminated encephalomyelitis include intravenous methylprednisolone, intravenous immunoglobulin or a combination of both. (biomedsearch.com)
Children with acute disseminated ence1
- Deep gray matter involvement in children with acute disseminated encephalomyelitis. (medscape.com)
Patients with acute disseminated ence1
- Cytokines and chemokines in cerebrospinal fluid and serum of adult patients with acute disseminated encephalomyelitis. (medscape.com)
Infection8
- Sacconi S, Salviati L, Merelli E. Acute disseminated encephalomyelitis associated with hepatitis C virus infection. (medscape.com)
- Various types of encephalomyelitis include: Acute disseminated encephalomyelitis or postinfectious encephalomyelitis, a demyelinating disease of the brain and spinal cord, possibly triggered by viral infection. (wikipedia.org)
- AIDS-related encephalomyelitis, caused by opportunistic Human T-lymphotropic virus type III (HTLV-III) infection. (wikipedia.org)
- Acute disseminated encephalomyelitis is a demyelinating disease, typically occurring in children following a febrile infection or a vaccination. (hindawi.com)
- A case report of a healthy 10-year-old boy with acute disseminated encephalomyelitis associated with acute acquired Toxoplasma gondii infection. (greenmedinfo.com)
- acute disseminated encephalomyelitis an acute or subacute encephalomyelitis or myelitis occurring most commonly following an acute viral infection, especially measles, but sometimes occurring without a recognizable antecedent. (thefreedictionary.com)
- acute disseminated encephalomyelitis inflammation of the brain and spinal cord after infection (especially measles) or, formerly, rabies vaccination. (thefreedictionary.com)
- This is the first longitudinal report of ZIKV infection causing encephalomyelitis with documented immune activation. (ovid.com)
Acute disseminated24
- National Organization for Rare Disorders: "Acute Disseminated Encephalomyelitis. (webmd.com)
- UpToDate: "Acute disseminated encephalomyelitis in children: Treatment and prognosis. (webmd.com)
- Acute disseminated encephalomyelitis followed by recurrent or monophasic optic neuritis in pediatric patients. (medscape.com)
- CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis. (medscape.com)
- Acute disseminated encephalomyelitis: clinical features, HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602, and HLA DPA1*0301 allelic association study. (medscape.com)
- Acute disseminated encephalomyelitis in childhood: report of 10 cases. (medscape.com)
- van der Meyden CH, de Villiers JF, Middlecote BD, Terblanchè J. Gadolinium ring enhancement and mass effect in acute disseminated encephalomyelitis. (medscape.com)
- Honkaniemi J, Dastidar P, Kähärä V, Haapasalo H. Delayed MR imaging changes in acute disseminated encephalomyelitis. (medscape.com)
- Role of plasmapheresis in acute disseminated (postinfectious) encephalomyelitis. (medscape.com)
- Acute disseminated encephalomyelitis at NIH's Office of Rare Diseases Acute Disseminated Encephalomyelitis Information Page at NINDS Pröbstel AK et al. (wikipedia.org)
- Our case is unique, as acute disseminated encephalomyelitis occurred in a 34-year-old which was poorly responsive to immunosuppression resulting in severe disability. (hindawi.com)
- Rossi A. Imaging of acute disseminated encephalomyelitis. (springer.com)
- Tenembaum S, Chamoles N, Fejerman N. Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients. (springer.com)
- Severe acute disseminated encephalomyelitis: a paediatric intensive care population-based study. (springer.com)
- A case report of acute disseminated encephalomyelitis after influenza vaccination. (greenmedinfo.com)
- A case report of acute disseminated encephalomyelitis triggered by toxic effect of synthetic cannabinoid black mamba. (greenmedinfo.com)
- Plasmapheresis in childhood acute disseminated encephalomyelitis. (biomedsearch.com)
- We used plasmapheresis to treat steroid non-responsive acute disseminated encephalomyelitis in two children. (biomedsearch.com)
- Acute disseminated encephalomyelitis with severe neurological outcomes following virosomal seasonal influenza vaccine. (greenmedinfo.com)
- Alves-Leon et al have found that the alleles HLA DQB1*0602, DRB1*1501, and DRB1*1503 confer genetic susceptibility to acute disseminated encephalomyelitis. (medscape.com)
- Acute disseminated encephalomyelitis (ADE) is a neurological disorder characterized by inflammation of the brain and spinal cord caused by damage to the myelin sheath. (cureresearch.com)
- Further information about the symptoms of Acute Disseminated Encephalomyelitis is available including a list of symptoms of Acute Disseminated Encephalomyelitis , or alternatively return to research other symptoms in the symptom center . (cureresearch.com)
- Various information is available about treatments available for Acute Disseminated Encephalomyelitis , or research treatments for other diseases. (cureresearch.com)
- Research more detailed information about the causes of Acute Disseminated Encephalomyelitis , other possibly hidden causes of Acute Disseminated Encephalomyelitis , or other general information about Acute Disseminated Encephalomyelitis . (cureresearch.com)
Diseases4
- AntiMOG associated encephalomyelitis, one of the underlying conditions for the phenotype neuromyelitis optica and in general all the spectrum of MOG autoantibody-associated demyelinating diseases. (wikipedia.org)
- Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): extending the spectrum of MOG antibody positive diseases. (springer.com)
- 1 The World Health Organization's International Classification of Diseases , Tenth Revision, can be accessed at http://apps.who.int/classifications/icd10/browse/2015/en (accessed February 13, 2015). (nap.edu)
- In addition to vaccination, infectious causes such as from bacteria, viruses, fungi, and tick-borne diseases can cause encephalomyelitis. (dogsnaturallymagazine.com)
Hemagglutinating encephalomyelitis virus1
- The causal betacoronavirus, porcine hemagglutinating encephalomyelitis virus (PHEV), is of a single antigenic type and is the only neurotropic coronavirus that affects swine. (merckvetmanual.com)
Encephalitis2
- Equine encephalomyelitis may refer to: Eastern equine encephalitis virus Western equine encephalitis virus Venezuelan equine encephalitis virus Viral encephalitis This article includes a list of related items that share the same name (or similar names). (wikipedia.org)
- Encephalomyelitis is often referred to as horse encephalitis (inflammation of the brain), sleeping sickness, blind staggers, and brain fever. (drugs.com)
Vaccine2
- This page contains information on Encephalomyelitis Vaccine Eastern & Western with Tetanus Toxoid for veterinary use . (drugs.com)
- The toxoid is refined to remove most of the nonspecific components and is concentrated to provide a low dose effective product for combination with Encephalomyelitis Vaccine fraction. (drugs.com)
Types of encephalomyelitis1
- When administered as directed this single product provides protection against Eastern and Western types of encephalomyelitis and against tetanus. (drugs.com)
Granulomatous encephalomyelitis2
- 1. Infected material from the brain and spinal cord of an infant suffering from a recently recognized form of granulomatous encephalomyelitis was inoculated into rabbits and mice and produced an experimental disease which was readily transmissible in series. (rupress.org)
- granulomatous encephalomyelitis a disease marked by granulomas and necrosis of the walls of the cerebral and spinal ventricles. (thefreedictionary.com)
Mice3
- Using the model system of Sindbis virus-induced encephalomyelitis in mice, we have shown that immune-mediated clearance of infectious virus from neurons is a noncytolytic process. (nih.gov)
- Using bovine αB-crystallin and synthetic peptides based on mouse αB-crystallin the ability of this stress protein to induce experimental allergic encephalomyelitis (EAE) was screened in Biozzi ABH (H-2A(g7)) mice. (tudelft.nl)
- A virus of the genus enterovirus , family picornaviridae , normally associated with inapparent infections and found in the intestinal tracts of infected mice , occasionally causing mouse encephalomyelitis in experimentally inoculated susceptible mice. (biology-online.org)
Disease3
- Since the lesions were confined to the central nervous system the disease is termed toxoplasmic encephalomyelitis. (rupress.org)
- Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Encephalomyelitis - Pipeline Review, H2 2017, provides an overview of the Encephalomyelitis (Central Nervous System) pipeline landscape. (mynewsdesk.com)
- Porcine hemagglutinating encephalomyelitis is a viral disease of piglets, characterized by a vomiting and wasting syndrome and/or encephalomyelitis. (merckvetmanual.com)
Benign1
- Benign relapsing meningo-encephalomyelitis. (bmj.com)
Viruses1
- Among the common causes of encephalomyelitis are viruses which infect the nervous tissues. (mynewsdesk.com)
Inflammation of the brain1
- Encephalomyelitis is inflammation of the brain and spinal cord. (wikipedia.org)
Clinical3
- Histopathology and clinical course of MOG-antibody-associated encephalomyelitis. (wikipedia.org)
- Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity. (bmj.com)
- Clinical signs in a chick affected with encephalomyelitis. (merckvetmanual.com)
Spinal cord2
- Encephalomyelitis can be caused by a variety of conditions that lead to irritation of the brain and spinal cord. (mynewsdesk.com)
- Viral encephalomyelitis is caused by virus infections of neurons in the brain and spinal cord. (nih.gov)
Rigidity2
- Progressive encephalomyelitis with rigidity and myoclonus (PERM) - A kind of stiff person syndrome. (wikipedia.org)
- 1 We report a 19 year old woman with stridor who developed progressive encephalomyelitis with rigidity (PER). (bmj.com)
MeSH1
- Encephalomyelitis, Equine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Plasmapheresis1
- The patient was treated for anti-NMDA receptor encephalomyelitis with immunosuppressive therapy, including rituximab and steroids, and plasmapheresis. (appliedradiology.com)
Neurologic1
- There is plenty of research that links neurologic disorders like encephalomyelitis to vaccination. (dogsnaturallymagazine.com)
Vaccination2
- A case report of encephalomyelitis and bilateral optic perineuritis caused by influenza vaccination. (greenmedinfo.com)
- Encevac-T with Havlogen is for the vaccination of healthy horses against Eastern and Western Encephalomyelitis (Sleeping Sickness). (jefferspet.com)