A salt-soluble precursor of elastin. Lysyl oxidase is instrumental in converting it to elastin in connective tissue.
A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.
Connective tissue comprised chiefly of elastic fibers. Elastic fibers have two components: ELASTIN and MICROFIBRILS.
2-(4-Amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinium. A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.
A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.
An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield peptidyl-allysyl-peptide plus ammonia & hydrogen peroxide. EC 1.4.3.13.
Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A pathological constriction occurring in the region above the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)
The main trunk of the systemic arteries.
A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a role in INFLAMMATION and WOUND HEALING.
A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.
Resistance and recovery from distortion of shape.
Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.
Components of the extracellular matrix consisting primarily of fibrillin. They are essential for the integrity of elastic fibers.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
The study of the physical and chemical properties of a drug and its dosage form as related to the onset, duration, and intensity of its action.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.
Organizations established by endowments with provision for future maintenance.
The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.
Gross hypo- or aplasia of one or more long bones of one or more limbs. The concept includes amelia, hemimelia, phocomelia, and sirenomelia.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Exclusive legal rights or privileges applied to inventions, plants, etc.
The combining of administrative and organizational resources of two or more health care facilities.
Services offered to the library user. They include reference and circulation.
The scientific study of past societies through artifacts, fossils, etc.
A class of animal lectins that bind specifically to beta-galactoside in a calcium-independent manner. Members of this class are distiguished from other lectins by the presence of a conserved carbohydrate recognition domain. The majority of proteins in this class bind to sugar molecules in a sulfhydryl-dependent manner and are often referred to as S-type lectins, however this property is not required for membership in this class.
Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of galactose with an alcohol to form an acetal. They include both alpha- and beta-galactosides.
A galectin found abundantly in smooth muscle (MUSCLE, SMOOTH) and SKELETAL MUSCLE and many other tissues. It occurs as a homodimer with two 14-kDa subunits.
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
A flat, flexible strip of material used to cover or fasten together damaged tissue.
Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.
The field of medicine concerned with physical fitness and the diagnosis and treatment of injuries sustained in exercise and sports activities.
Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.
Adhesive tape with the mechanical strength to resist stretching. It is applied to the skin to support, stabilize, and restrict movement to aid healing and/or prevent injuries of MUSCULOSKELETAL SYSTEM.
Substances and materials manufactured for use in various technologies and industries and for domestic use.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
Formal voluntary or governmental procedures and standards required of hospitals and health or other facilities to improve operating efficiency, and for the protection of the consumer.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.

Repopulation of different layers of host human Bruch's membrane by retinal pigment epithelial cell grafts. (1/1299)

PURPOSE: To determine the morphology of human retinal pigment epithelium (RPE) after reattachment to different ultrastructural layers of human Bruch's membrane (BM). METHODS: Bruch's membrane explants were prepared from eyes of 23 human donors (age range, 11-89 years). The basal lamina of the RPE, inner collagenous layer, and elastin layer were removed sequentially by mechanical and enzymatic techniques. First-passage cells of human RPE (15,000 cells/6 mm explant) from three donors (ages, 52, 64, and 80 years) were plated onto different layers of human BM, and the explants were examined by scanning and transmission electron microscopy up to 21 days later. RESULTS: RPE flattened and extended footplates 6 hours after plating onto basal lamina. Cells remained round 6 and 24 hours after plating onto the inner collagenous, elastin, or outer collagenous layer. The RPE cells became confluent 14 days after plating onto basal lamina but did not become confluent up to 21 days after plating onto the inner collagenous or elastin layer. Sparse round cells were observed 21 days after plating onto deeper layers, suggesting extensive loss of RPE. CONCLUSIONS: The morphology and subsequent behavior of the RPE reattached to BM depends on the anatomic layer of BM available for cell reattachment. The results suggest that the ability of transplanted RPE to repopulate BM in age-related macular degeneration and other disorders may depend on the layer of BM available to serve as a substrate for cell reattachment.  (+info)

Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). (2/1299)

BACKGROUND: Abdominal aortic aneurysms (AAAs) are associated with chronic inflammation, disruption of medial elastin, and increased local production of elastolytic matrix metalloproteinases (MMPs). The purpose of this study was to investigate how treatment with a hydroxamate-based MMP antagonist (RS 132908) might affect the development of experimental AAAs. METHODS: Male Wistar rats underwent intraluminal perfusion of the abdominal aorta with 50 units of porcine pancreatic elastase followed by treatment for 14 days with RS 132908 (100 mg/kg/day subcutaneously; n = 8) or with vehicle alone (n = 6). The external aortic diameter (AD) was measured in millimeters before elastase perfusion and at death, with AAA defined as an increase in AD (DeltaAD) of at least 100%. Aortic wall elastin and collagen concentrations were measured with assays for desmosine and hydroxyproline, and fixed aortic tissues were examined by light microscopy. RESULTS: AAAs developed in all vehicle-treated rats, with a mean AD (+/- SE) that increased from 1.60 +/- 0.03 mm before perfusion to 5.98 +/- 1.02 mm on day 14 (DeltaAD = 276.4 +/- 67.7%). AAAs developed in only five of eight animals (62.5%) after MMP inhibition, with a mean AD that increased from 1.56 +/- 0.05 mm to 3.59 +/- 0.34 mm (DeltaAD = 128.1 +/- 18.7%; P <.05, vs vehicle). The overall inhibition of aortic dilatation attributable to RS 132908 was 53.6 +/- 6.8%. Aortic wall desmosine fell by 85.4% in the vehicle-treated rats (1210.6 +/- 87.8 pmol/sample to 176.7 +/- 33.4 pmol/sample; P <.05) but only by 65.6% in the animals treated with RS 312908 (416.2 +/- 120.5 pmol/sample). In contrast, hydroxyproline was not significantly affected by either elastase perfusion or drug treatment. Microscopic examination revealed the preservation of pericellular elastin and a greater degree of fibrocollagenous wall thickening after MMP inhibition, with no detectable difference in the extent of inflammation. CONCLUSIONS: Systemic MMP inhibition suppresses aneurysmal dilatation in the elastase-induced rodent model of AAA. Consistent with its direct inhibitory effect on various MMPs, RS 132908 promotes the preservation of aortic elastin and appears to enhance a profibrotic response within the aortic wall. Hydroxamate-based MMP antagonists may therefore be useful in the development of pharmacologic approaches to the suppression of AAAs.  (+info)

Connective tissues: matrix composition and its relevance to physical therapy. (3/1299)

In the last 2 decades, the understanding of CT structure and function has increased enormously. It is now clear that the cells of the various CTs synthesize a variety of ECM components that act not only to underpin the specific biomechanical and functional properties of tissues, but also to regulate a variety of cellular functions. Importantly for the physical therapist, and as discussed above, CTs are responsive to changes in the mechanical environment, both naturally occurring and applied. The relative proportions of collagens and PGs largely determine the mechanical properties of CTs. The relationship between the fibril-forming collagens and PG concentration is reciprocal. Connective tissues designed to resist high tensile forces are high in collagen and low in total PG content (mostly dermatan sulphate PGs), whereas CTs subjected to compressive forces have a greater PG content (mostly chondroitin sulphate PGs). Hyaluronan has multiple roles and not only provides tissue hydration and facilitation of gliding and sliding movements but also forms an integral component of large PG aggregates in pressure-resisting tissues. The smaller glycoproteins help to stabilize and link collagens and PGs to the cell surface. The result is a complex interacting network of matrix molecules, which determines both the mechanical properties and the metabolic responses of tissues. Patients with CT problems affecting movement are frequently examined and treated by physical therapists. A knowledge of the CT matrix composition and its relationship to the biomechanical properties of these tissues, particularly the predictable responses to changing mechanical forces, offers an opportunity to provide a rational basis for treatments. The complexity of the interplay among the components, however, requires that further research be undertaken to determine more precisely the effects of treatments on the structure and function of CTs.  (+info)

Interaction between leukocyte elastase and elastin: quantitative and catalytic analyses. (4/1299)

Solubilization of elastin by human leukocyte elastase (HLE) cannot be analyzed by conventional kinetic methods because the biologically relevant substrate is insoluble and the concentration of enzyme-substrate complex has no physical meaning. We now report quantitative measurements of the binding and catalytic interaction between HLE and elastin permitted by analogy to receptor-ligand systems. Our results indicated that a limited and relatively constant number of enzyme binding sites were available on elastin, and that new sites became accessible as catalysis proceeded. The activation energies and solvent deuterium isotope effects were similar for catalysis of elastin and a soluble peptide substrate by HLE, yet the turnover number for HLE digestion of elastin was 200-2000-fold lower than that of HLE acting on soluble peptide substrates. Analysis of the binding of HLE to elastin at 0 degrees C, in the absence of significant catalytic activity, demonstrated two classes of binding sites (Kd=9.3x10(-9) M and 2.5x10(-7) M). The higher affinity sites accounted for only 6% of the total HLE binding capacity, but essentially all of the catalytic activity, and dissociation of HLE from these sites was minimal. Our studies suggest that interaction of HLE with elastin in vivo may be very persistent and permit progressive solubilization of this structurally important extracellular matrix component.  (+info)

UVB irradiation stimulates deposition of new elastic fibers by modified epithelial cells surrounding the hair follicles and sebaceous glands in mice. (5/1299)

UVB irradiation stimulates the synthesis of elastin in the skin of humans and experimental animals. In this study we localized the site and the cells that are responsible for the synthesis of murine dermal elastic fibers. SKH-1 hairless mice were irradiated with UVB and the skin removed for light microscopy, electron microscopy, in situ hybridization, immunohistochemistry, and biochemical studies. In response to chronic low doses of UVB there was an initial moderate increase in tropoelastin mRNA in the papillary dermis. By contrast, there was a continuous marked elevation of collagen alpha1(I) message localizing to sites of inflammatory cell influx throughout the upper and lower dermis. After 25 wk of UV irradiation there was a 2-fold increase in skin elastin, yet total collagen remained unchanged. Serial desmosine analysis from en face sections indicated the increase in elastin content was due to dermal elastic fibers, an increase in the size and number of the dermal cysts, and an increase in subpanniculus elastic fibers. Elastin stains of en face sections suggested that the elastic fibers in the upper dermis were exclusively derived from cells lining the epithelial root sheath and sebaceous glands. In response to UV irradiation, the elastic fibers increased in number and size, wrapping around these structures and aligning in both directions as long fibers parallel to the body axis. Electron micrographs indicated that modified epithelial cells in close proximity to the flattened epithelial cells that encircled the root sheath and sebaceous glands were the source of the elastic fibers.  (+info)

Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis. (6/1299)

Serine elastases degrade elastin, stimulate vascular smooth muscle cell migration and proliferation, and are associated with myocardial damage. To evaluate the impact of elastase inhibition on cardiovascular development and disease, transgenic mice were created in which the mouse preproendothelin-1 promoter was used to target elafin overexpression to the cardiovascular system. To distinguish the transgene from endogenous elafin, constructs were made incorporating a FLAG sequence; the COOH-terminus FLAG-tagged elafin construct produced a stable, functionally active gene product and was used to create transgenic mice. Consistent with endothelin expression, abundant elafin mRNA was observed in transgenic F1 embryos (embryonic day 13.5) and in adult transgenic mice heart, trachea, aorta, kidney, lung, and skin, but not in liver, spleen, and intestine. Functional activity of the transgene was confirmed by heightened myocardial elastase inhibitory activity. No tissue abnormalities were detected by light microscopy or elastin content. However, injection of 10 plaque-forming units (PFU) of encephalomyocarditis virus resulted in death within 11 days in 10 out of 12 nontransgenic mice compared with one out of nine transgenic littermates. This reduced mortality was associated with better cardiac function and less myocardial inflammatory damage. Thus, elafin expression may confer a protective advantage in myocarditis and other inflammatory diseases.  (+info)

The smooth muscle cell. III. Elastin synthesis in arterial smooth muscle cell culture. (7/1299)

Primate arterial smooth muscle cells and skin fibroblasts were examined for their ability to synthesize elastin in culture. In the presence of the lathyrogen beta-aminopropionitrile, the smooth muscle cells incorporate [3H]lysine into a lysyl oxidase substrate that was present in the medium and associated with the cell layer. A component having a mol wt of 72,000 and an electrophoretic mobility similar to that of authentic tropoelastin was isolated from the labeled smooth muscle cells by coacervation and fractionation with organic solvents. In the absence of beta-aminopropionitrile, long-term cultures of smooth muscle cells incorporated [14C]lysine into desmosine and isodesmosine, the cross-link amino acids unique to elastin. In contrast, no desmosine formation occurred in the fibroblast cultures. These characteristics demonstrate that arterial smooth muscle cells are capable of synthesizing both soluble and cross-lined elastin in culture.  (+info)

Identification of a large region of secondary structure in the 3'-untranslated region of chicken elastin mRNA with implications for the regulation of mRNA stability. (8/1299)

Synthesis of aortic elastin peaks in the perinatal period and then is strongly down-regulated with postnatal vascular development. Our laboratory has previously shown that changes in elastin mRNA stability contribute to this developmental decrease in elastin production. Here we identify a large region of stable secondary structure in the 3'-untranslated region (3'-UTR) of chicken elastin mRNA. Reverse transcriptase polymerase chain reaction or polymerase chain reaction amplification of the 3'-UTR consistently resulted in products with an approximately 328-bp deletion from the central region of the 3'-UTR, suggesting the presence of secondary structure. The presence of this structure was confirmed by probing the 3'-UTR with RNases with selectivity for single- or double-stranded RNA. Gel migration shift assays using cytosolic extracts from 2-day old chicken aorta demonstrate specific binding of a cytosolic protein to riboprobes containing the 3'-UTR of elastin but not to riboprobes either corresponding to other areas of the message or containing the 3'-UTR but lacking the region of secondary structure. Binding of cytosolic protein was particularly prominent in aortic extracts from 2-day old chickens, a time when elastin message is stable, as compared with 8- and 15-week old chickens, when the elastin message is relatively unstable, suggesting that this region of secondary structure may play a role in developmental regulation of stability of elastin mRNA.  (+info)

Patients with COPD have evidence of greater cutaneous elastin degradation than age- and smoking-matched controls. Our findings represent evidence of enhanced degradation of elastin outside of the lung in COPD, and we believe that systemic elastin degradation may be a novel systemic feature of COPD. Furthermore, we have found increased expression of MMP-9 in the skin of patients with COPD, a protease implicated in the pathogenesis of emphysema, and these data suggest a role in systemic elastin degradation in COPD.. Elastin degradation in non-sun-exposed skin was associated with both emphysema severity and aortic pulse wave velocity. We speculate that the systemic elastin degradation demonstrated in the skin may also occur in other elastin-rich structures, such as the walls of large conduit arteries, and is an explanation for the increased arterial stiffness in COPD.. Development of emphysema, arterial stiffness and elastin degradation are features of normal ageing, reinforcing the importance of ...
Mice deficient in the macrophage elastase matrix metalloproteinase-12 (MMP-12) do not develop cigarette smoke induced emphysema or show high levels of macrophage accumulation in the lung on exposure to cigarette smoke. However, monocyte migration to the lung in MMP-12 deficient mice can occur in the presence of an appropriate stimulus. This study used an in vivo model to investigate that stimulus.. Bronchoalveolar lavage (BAL) fluid from wild-type smoke exposed mice (and not MMP-12 deficient controls) showed monocyte chemotactic activity. MMP-12 itself was not chemotactic. Fractionation of BAL fluid from wild-type mice found that elastin fragments were the only matrix protein fragments present in the chemotactic fraction of the fluid. The use of an elastin fragment antibody resulted in monocyte chemotaxis inhibition, even in the presence of cigarette smoke.. Porcine pancreatic elastase generates a model of emphysema that closely resembles human emphysema. Elastin fragment inhibition by elastin ...
TY - JOUR. T1 - Neutrophil elastase and elastin-derived peptides in BAL fluid and emphysematous changes on CT scans. AU - Betsuyaku, T.. AU - Nishimura, M.. AU - Yoshioka, A.. AU - Takeyabu, K.. AU - Miyamoto, K.. AU - Kawakami, Y.. PY - 1996/12/1. Y1 - 1996/12/1. N2 - We examined the relationship between neutrophil elastase, elatin- derived peptides in bronchoalveolar lavage (BAL) fluid, and the development of pulmonary emphysema. The level of neutrophil elastase was higher in asymptomatic current smokers with emphysematous changes on computed tomographic scans than in current smokers without emphysematous changes, and was found to be correlated with the level of elastin-derived peptides in BAL fluid. Subjects with high levels of neutrophil elastase in BAL fluid had faster annual declines in FEV1. We conclude that the level of neutrophil elastase in BAL fluid can be used to differentiate asymptomatic cigarette smokers who are at risk for pulmonary emphysema from those who are not.. AB - We ...
Rationale: After a myocardial infarction, necrosed cardiomyocytes are replaced by fibrotic tissue. Subsequent thinning and expansion of this non-elastic scar contributes to cardiac dilatation and congestive heart failure. We attempted to restore the elastic properties of the scar by implanting the infarct area with cells expressing elastin.. Methods: Full-length elastin cDNA was generated by PCR using the human lung cDNA library, and then transfected (in adenoviral vector) into rat bone marrow stromal cells (BMSCs). Western blot and immuno-staining confirmed expression of elastin protein. Seven days after coronary artery ligation, BMSCs transfected with genes for either adeno-elastin (BMSC+Elastin) or adeno-green fluorescence protein (BMSC), or media (control group) were injected into the infarct area of adult rats (n=8/group).. Results: Over 8 weeks following cell or media implantation, cardiac function (fractional shortening by echocardiography), ventricular volumes, and load independent ...
Laurent Debelle, Alain Alix, Shao Wei, Marie-Paule Jacob, Jean-Pierre Huvenne, et al.. The secondary structure and architecture of human elastin. European Journal of Biochemistry, Wiley, 1998, 258 (2), pp.533-539. ⟨10.1046/j.1432-1327.1998.2580533.x⟩. ⟨hal-02328617⟩ ...
We demonstrated that PRT-201 fragments elastin, a protein present in blood vessel walls. The fragmentation of elastin in the outside wall of the blood vessel is thought to inhibit formation of neointimal hyperplasia thereby reducing the risk of patency loss. Elastase causes localized fragmentation of elastin protein fibers present in blood vessel walls. The elastin fragments generated by elastase are chemoattractants for scar forming cells, meaning that the fragments attract these scar forming cells, inhibiting their migration to the lumen. The cells recognize the elastin fragments via receptors present on the cell surface that bind to specific elastin fragment sub-types. The importance of elastin fragments in vascular biology, including the response to vascular injury has been established in the scientific literature over three decades. Published academic studies conducted in animals provide evidence that fragmentation of elastin in the outer wall of the blood vessels from administration of ...
ELASTIN | Elastin Protein Gel for aesthetic medicine treatments Contains elastin proteins for rejuvenation! Elasticity booster! Paraben and fragrance free!
ELASTIN | Elastin Protein Gel for aesthetic medicine treatments Contains elastin proteins for rejuvenation! Elasticity booster! Paraben and fragrance free!
ELASTIN | Elastin Protein Gel for aesthetic medicine treatments Contains elastin proteins for rejuvenation! Elasticity booster! Paraben and fragrance free!
Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death ...
The elastin receptor complex contains a component of 67 kilodaltons that binds to a glycoconjugate affinity column containing beta-galactoside residues and is eluted from this column with lactose. This protein component is also released from the surface of cultured chondroblasts by incubation with lactose, and its association with immobilized elastin is inhibited by lactose. Since lactose also blocks elastic fiber formation by cultured chondroblasts, the galactoside-binding property of the elastin receptor is implicated in this process. ...
While characterizing developmental changes in aortic wall composition in sheep, we observed very rapid accumulation of elastin and collagen in the immediate perinatal period. Thoracic aortic elastin content increased by 41%, and collagen content increased by 49% in approximately 1 week, between 140 days gestation and 3 days postpartum (term = 145 days). Even larger changes were observed in the abdominal aorta. Elastin content increased by 66%, and collagen increased by 57%. The pronounced increase in wall tissue accumulation near birth preceded a marked postnatal increase in arterial pressure. We propose that this elastin and collagen accumulation is a preadaptive response in preparation for the later increase in pressure. The prenatal and postnatal events that initiate this synthesis and accumulation are not known. We also found that, in the 3 weeks after this initial rapid increase, accumulation of elastin and collagen was markedly reduced in the abdominal, but not the thoracic, aorta. This ...
Elastomeric proteins are known by their great resilient properties being able to withstand significant deformations without rupture, returning to their original state when the stress is removed. In this family we find elastin like polymers (ELPs) that have the ability to undergo inverse temperature transition1 along with other smart behaviour properties. Furthermore, they present astonishing biocompatibility, making them ideal for a huge range of applications especially in health sciences. Ind this work we have studied the production of GAG220, and ELP composed by the monomer VPAVG, expressed by E. coli. Since GAG220 and the culture medium used were designed by us it is vital to understand the polymer kinetics formation profile in order to identify the peak of production. A set of experiments was planned comprising a screening of the production at different environmental conditions, namely incubation temperature, dissolved oxygen tension and primary carbon source concentration. The results ...
The physical and chemical properties of the mammalian aorta are known to vary as a function of distance from the heart. These properties are highly dependent collagen and elastic fibers. In order to evaluate the mechanisms which regulate the accumulation of these two connective tissue proteins, gene expression was evaluated at both the biosynthetic and messenger RNA levels. Short-term (3 h) explant cultures of the medial portion of four segments of the descending aorta in newborn pigs were incubated in the presence of [3H] proline. Collagen production was quantified by collagenase digestion and elastin production was determined by immunoprecipitation. Between the conus arteriosus and the bifurcation of the iliac arteries, relative collagen synthesis increased 2-fold (from 5.8 to 12.0% of total protein synthesis), while relative elastin synthesis declined 10-fold (from 16.4 to 1.6% of total protein synthesis). Similarly, collagen production increased more than 7-fold (from 6.7 to 49.8 X 10(3) molecules
At the interface of organic and aqueous solvents, tailored amphiphilic elastin-like proteins assemble into complex supramolecular...
Ever wondered how to get more elastin in skin without getting those injections? Curious to know how to increase both collagen and eliastin in your skin the chemical free, safe and healthy way?. One thing you should know first though…your skin doesnt stay soft, firm and supple as the years roll by. Why? The main reason - the loss of the two vital skin proteins called collagen and elastin.. This is simply part of the aging process. In your earlier years, the collagen and elastin content of human skin was at high levels.. But now, the loss of collagen and elastin in skin starts appearing. As time slips by, skin starts to sag, develop fine lines and winkles which are all due to a breakdown of those two proteins.. Many people dont know this, but the skincare products advertised that claim to add back elastin in skin dont work. You can apply all the skincare cream that says collagen elastin added on the label but youre wasting your time and money.. The reason - those two proteins are much too ...
Ever wondered how to get more elastin in skin without getting those injections? Curious to know how to increase both collagen and eliastin in your skin the chemical free, safe and healthy way?. One thing you should know first though…your skin doesnt stay soft, firm and supple as the years roll by. Why? The main reason - the loss of the two vital skin proteins called collagen and elastin.. This is simply part of the aging process. In your earlier years, the collagen and elastin content of human skin was at high levels.. But now, the loss of collagen and elastin in skin starts appearing. As time slips by, skin starts to sag, develop fine lines and winkles which are all due to a breakdown of those two proteins.. Many people dont know this, but the skincare products advertised that claim to add back elastin in skin dont work. You can apply all the skincare cream that says collagen elastin added on the label but youre wasting your time and money.. The reason - those two proteins are much too ...
Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide and is now the third leading cause of death in the United States. There is a lack of therapies that can stop progression of the disease and improve survival. New drug discovery can be aided by the development of biomarkers, which can act as indicators of severity in the course of the disease and responses to therapy. This perspective brings together the laboratory and clinical evidence, which suggest that elastin degradation products can fulfill the need for such a biomarker. Elastin is a recognized target for injury in COPD. The amino acids desmosine and isodesmosine exist only in matrix elastin; can be measured specifically and sensitively in plasma, urine, and sputum; and indicate changes in the systemic balance between elastase activity and elastase inhibition brought on by the systemic inflammatory state. The biomarker levels in sputum reflect the state of elastin degradation in the lung specifically. Clinical ...
The intracellular domains of the membrane-anchoring regions of some precursors of epidermal growth factor (EGF) family members have intrinsic biologic activities. We have determined the role of the human proEGF cytoplasmic domain (proEGFcyt) as part of the proEGF transmembrane-anchored region (proEGFctF) in the regulation of motility and elastinolytic invasion in human thyroid cancer cells. We found proEGFctF to act as a negative regulator of motility and elastin matrix penetration and the presence of proEGFcyt or proEGF22.23 resulted in a similar reduction in motility and elastinolytic migration. This activity was counteracted by EGF-induced activation of EGF receptor signaling. Decreased elastinolytic migratory activity in the presence of proEGFctF and proEGFcyt/proEGF22.23 coincided with decreased secretion of elastinolytic procathepsin L. The presence of proEGFctF and proEGFcyt/proEGF22.23 coincided with the specific transcriptional up-regulation of t-SNARE member SNAP25. Treatment with ...
Having beautiful, smooth and firm skin allows one to feel good about their appearance and have a healthy self-image - qualities that help people live better, longer. To this end, biochemist Dr Chantal Burnison designed the breakthrough ingredient Ethocyn, used in the finest wrinkle creams today. As confirmed by eminent M.D. and skin physiologist Dr. Peter T. Pugliese, The single most important cause of age related skin wrinkles and sagging is the loss of skin elastin fibers. Everyone, whether female or male, will begin to lose skin elastin fibers at age 25. Elastin fibers are the restorative force in the skin.. Elastin gives the skin resiliency and the ability to stretch and snap back into shape, much like a rubber band. When we are young, our skin has high levels of elastin - on average, 14-18 percent. As we age, our elastin levels naturally decrease. Clinical trials confirm that in patients 40 years and older elastin levels drop to as low as .1% and on average are in the 9% range. For this ...
Peptide Cream elastin Patented elastin, which was developed specifically for wrinkle treatment Anti-Wrinkle Peptide complex (the pentapeptide-37) to eliminate wrinkles by stimulating collagen synthesis in the skin and elastin and the skin will help to restore healthy. Resveratrox, two of vine with edible roots of grapevines obtained Ecocert certified and patented assets. The treatment of deep wrinkles associated with aging, regeneration of the skin smoother and helps to look young. It has the same effects as retinoic acid. With hyaluronic acid provides the skin constantly moist, supports the synthesis of elastin, helps cell regeneration. Co-Enzyme Q-10 is a powerful antioxidant present in the cell. Protects skin against aging, it plays an important role as an antioxidant in cell membranes. With nourishing oil complex, dry, worn, cracked skin cells and accelerates the regeneration, it helps normalize the skin. With Plantfluid Plant Complex, nourishes the skin, restores, rejuvenates, tightens
Collagens and elastin are important proteins that provide skin its firmness and elasticity. Skin care products have incorporated ingredients that indirectly help maintain and generate skin collagens and elastin for the past years. The new trend, on the other hand, is to dig into the cellular level metabolic mechanism of senescent fibroblasts directly. Last year, Induchem companies produced a new complex named Neodermyl, which could provide what skin cells needed to build collagens and elastin.. Neodermyl is Methyl Glucoside Phosphate Proline Lysine Copper Complex. The long name indicates what active ingredients Neodermyl contains. They are three groups of ingredients, each of which is necessary to feed and regulate cellular collagen and elastin synthesis. First, Neodermyl provides MG6P (Methyl-Glucoside-6-Phosphate). MG6P is pre-activated glucose that can feed skin cells with energy without causing harmful glycation. Then, proline and lysine in Neodermyl are amino acids. How proline and lysine ...
Substances like Cynergy TK(TM) that contains functional keratin(TM) can stimulate elastin and collagen re-growth in your skin. For elastin and collagen to grow these proteins have to be stimulated by another substance that is capable of making this production possible.
Substances like Cynergy TK(TM) that contains functional keratin(TM) can stimulate elastin and collagen re-growth in your skin. For elastin and collagen to grow these proteins have to be stimulated by another substance that is capable of making this production possible.
To get the Most Elegant Build. In order to get the most perfect and elegant build, you must let the face rest a bit. The muscles of the face, which are organically built … meaning we actually build muscle fiber through resistance training and consequently get larger muscles, giving us a firmer, fuller look, needs this rest period to give the most elegant build possible. We need this volume in our faces to look youthful and well … more rounded.. Elastin Fibers are Key. We are always building elastin fibers as we age. When were younger, we build them in abundance. As we age, they build slower and therefore there are less of them, but we do continue to build elastin fibers. Elastin Fibers are the stretchy tissue that helps to keep the connective tissue in our faces (and bodies) be flexible and together. They are environmentally challenged … meaning they can break from sun damage, smoking cigarettes, pollution, etc... Now elastin fibers are very interesting. When they grow in they take on ...
There are many elastin special stain techniques such as Weigert-Type, Orcein, Aldehyde-Fuchsin and Verhoeffs. The most common is Verhoeffs technique of staining elastin due to its quick method and strong elastin colour result. Below is the authors favoured method for demonstrating elastin which is a version of the Verhoeffs. ...
Another more commonly known important substance CoenzymeQ10 is included. However it\s in the special nano-emulsion form Nano-Lipobelle H-EQ10 that is small enough to penetrate the skin to once again stimulate the production of new collagen and elastin protein skin cells ...
Researchers from Jefferson Medical College of Thomas Jefferson University, Philadelphia, have developed the first transgenic, or genetically altered, mouse used to study the causes and effects of photoaging on human skin. The mouse line, developed by microinjecting fertlized mouse eggs with human elastin promoter DNA, which produces skin fibers that promote elasticity, has enabled researchers to learn more about how the ultraviolet light causes skin aging and wrinkling.
Chronic obstructive pulmonary disease and emphysema are associated with increased elastin peptides (EP) production because of excessive breakdown of lung connective tissue. We recently reported that exposure of mice to EP elicited hallmark features of emphysema. EP effects are largely mediated through a receptor complex that includes the elastin-binding protein spliced-galactosidase (S-gal). In previous studies, we established a correlation between cytokine production and S-gal protein expression in EP-treated immune cells. In this study, we investigated the S-gal-dependent EP effects on T-helper (Th) and T-cytotoxic (Tc) responses during murine EP-triggered pulmonary inflammation. C57BL/6J mice were endotracheally instilled with the valine-glycine-valine-alanine-proline-glycine (VGVAPG) elastin peptide, and, 21 days after treatment, local and systemic T-lymphocyte phenotypes were analyzed at cytokine and transcription factor expression levels by multicolor flow cytometry. Exposure of mice to ...
The artificial elastin 100xELP has high similarity to human elastin and consists of oligomeric repeats of the pentapaptide Val-Pro-Gly-Xaa-Gly (Xaa - any amino acid but proline). Hence it solely consists of units that resemble the hydrophobic domain of natural elastin. Therefore it is not able to be linked to a network. However, 100xELP exhibits a good ability to be solved in aqueous solution depending on the salt concentration and temperature. It can undergo an inverse transition, i.e. the protein is soluble in an aqueous solution below its transition temperature but insoluble above this critical value ...
Chronic obstructive pulmonary disease (COPD) is a common lung disease with cigarette smoking as the major etiological factor, but only 15% of smokers develop COPD. Destruction of lung elastin observed in COPD is mediated by many enzymes, including cysteine, serine, and matrix metalloproteinases (MMP). The contribution of these enzymes to the lung elastolytic load, released from alveolar macrophages collected from nonsmokers, healthy smokers, and COPD patients, was examined by radiolabeled elastin as substrate in the presence of specific enzyme inhibitors. The activity of MMP was further examined by zymography and Western blotting. COPD macrophages degraded more elastin than either of the other groups. Elastolysis was greatest in the initial 24 h. Through the 72-h culture period, the contribution to elastolysis of serine elastases decreased, MMP increased, and cysteine elastases remained constant. The increased release of elastolytic enzymes in COPD subjects may explain why some smokers develop COPD.
21st Century Malaysia Elastin Collagen 600mg, 30 vegetarian capsules [30s] - ELASTIN COLLAGEN CAPSULES, 30s Elastin Collagen 600 mg Our skin changes over time, leading to visible signs of aging, like a loss of elasticity, increased skin roughness, uneven skin tone, wrinkles and fine lines. Our skin is comprised of two layers, known as the epidermis and dermis. The dermis contains collagen and
Elastin Collagen is an advanced firming nourish lotion suitable for all skin types concerned with anti-aging. A non-greasy, lightweight moisturizer with Elastin & Collagen to firm, improve elasticity and restore skin suppleness. Squalane, derived from olives, is a natural nourishment to parched skin. Allantoin is a natural botanical extract used to promote healthy skin renewal effects. Ingredients: AQUA (WATER), ISOCETYL STEARATE, BUTYLENE GLYCOL, GLYCERIN, ROSE WATER CONCENTRATE, CETYL ALCOHOL, STEARIC ACID, STEARYL ALCOHOL, GLYCERYL STEARATE, HYDROLYZED COLLAGEN, HYDROLYZED ELASTIN, SODIUM LAURYL SULFATE, TRIETHANOLAMINE, SQUALANE OIL, 3-AMINOPROPYL DIHYDROGEN PHOSPHATE, ALLANTOIN, LACTIC ACID, PHENOXYETHANOL, ETHYLHEXYLGLYCERIN
Complete the quiz and worksheet to check your understanding of comparing collagen and elastin fibers. Gain access to these materials whenever you...
Revuele Bio Active Skin Care Collagen & Elastin Tightening Night Cream - 50ml Prevents premature destruction of collagen fibers and skin aging, stimulates cell regeneration as well as collagen and elastin production which are processes that are especially
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Introduction: Accelerated arterial stiffening is a common complication of type 2 diabetes that is patho-mechanistically linked to a severely increased cardiovascular risk. Unfortunately, up to date specific strategies to effectively address diabetic vascular stiffening are elusive. The discovery of non-coding microRNAs (miRs) provides new opportunities for innovative therapeutical approaches. Specifically, microRNA-29b may potentially serve as a comprehensive regulator of vascular fibrosis as well as elastin breakdown, both contributing to diabetic arterial stiffness.. Objective: This study was designed to investigate the role of miR-29b as potential mediator and therapeutic target of diabetic aortic stiffness.. Method and Results: Ex vivo mechanical testing of thoracic aortae via pressure myography revealed increased aortic stiffness in diabetic db/db mice. Vascular stiffening was accompanied by increased elastin fragmentation and collagen deposition (EvG and Picrosirius Red staining). qRT-PCR, ...
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A study of the affinities for cholesterol from serum lipoproteins by elastin and collagen components of the arterial wall was undertaken. The low-density lipoproteins (LDL) of human serum and very low-density lipoproteins (VLDL) of rabbit serum were incubated with bovine tendon collagen and with porcine aortic elastin. Cholesterol analysis of the elastin residues revealed a significant ability of the elastin to bind the lipoprotein cholesterol. Succinylation of the LDL did not seem to inhibit the amount of cholesterol transfer. The collagen also bound cholesterol but to a lesser extent. A concurrent project of tissue culturing aortas from various animals with primary interest in growth rate was done. A strain of Japanese quail resistant to experimental atherosclerosis (REA) showed significantly less proliferation of cells as compared with a strain susceptible to experimental atherosclerosis (SEA) grown under identical conditions which may suggest something about the genetic predispositions to ...
The formation of a mature elastic fiber is thought to proceed by the deposition of elastin on pre-existing microfibrils (10-12 nm in diameter). Immunohistochemical evidence has suggested that in developing tissues such as aorta and ligamentum nuchae, small amounts of elastin are associated with microfibrils but are not detected at the light microscopic and ultrastructural levels. Dermal tissue contains a complex elastic fiber system consisting of three types of fibers--oxytalan, elaunin, and elastic--which are believed to differ in their relative contents of microfibrils and elastin. According to ultrastructural analysis, oxytalan fibers contain only microfibrils, elaunin fibers contain small quantities of amorphous elastin, and elastic fibers are predominantly elastin. Using indirect immunofluorescence techniques, we demonstrate in this study that nonamorphous elastin is associated with the oxytalan fibers. Frozen sections of normal skin were incubated with antibodies directed against human ...
TY - JOUR. T1 - A 30 kb deletion within the elastin gene results in familial supravalvular aortic stenosis. AU - Olson, Timothy Mark. AU - Michels, V. V.. AU - Urban, Z.. AU - Csiszar, K.. AU - Christiano, A. M.. AU - Driscoll, D. J.. AU - Feldt, R. H.. AU - Boyd, C. D.. AU - Thibodeau, Stephen N. PY - 1995. Y1 - 1995. UR - http://www.scopus.com/inward/record.url?scp=0029145430&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0029145430&partnerID=8YFLogxK. M3 - Article. C2 - 8541862. AN - SCOPUS:0029145430. VL - 4. SP - 1677. EP - 1679. JO - Human Molecular Genetics. JF - Human Molecular Genetics. SN - 0964-6906. IS - 9. ER - ...
Background: Elastin-like polypeptides are synthetic biopolymers composed of a repeating pentapeptide VPGXG sequence that are valuable for the simple non-chromatographic purification of recombinant proteins. In addition, elastin-like polypeptide fusions have been shown to enhance the accumulation of a range of different recombinant proteins in plants, thus addressing the major limitation of plant-based expression systems, which is a low production yield. This studys main objectives were to determine the general utility of elastin-like polypeptide protein fusions in various intracellular compartments and to elucidate elastin-like polypeptides mechanism of action for increasing recombinant protein accumulation in the endoplasmic reticulum of plants. Results: The effect of elastin-like polypeptide fusions on the accumulation of green fluorescent protein targeted to the cytoplasm, chloroplasts, apoplast, and endoplasmic reticulum was evaluated. The endoplasmic reticulum was the only intracellular
Biodegradation has been one of the most important determinants used to ascertain the efficacy of the polymers that are frequently used in drug delivery. The study design of this project focused on a series of the protein polymers derived from the human tropoelastin protein to examine the specific mechanisms of biodegradation. Elastin-like polypeptides (ELPs) are non-immunogenic and biocompatible polymers composed of pentapeptide repeats of Val-Pro-Gly-Xaa-Gly where Xaa can be any amino acid. They undergo inverse phase transition during which they remain in solution below the transition temperature (Tt) but collapse and clump together to form aggregates when heated above their Tt. In this study, ELP mono and di-blocks were treated with proteases like elastase and collagenase below and above their Tt in order to learn if their property of transitioning provided them with a protective advantage over the action of these enzymes. Elastase was significantly able to digest all the ELPs at both the ...
Elastin is made by linking together many small soluble precursor tropoelastin protein molecules (50-70 kDa), to make the final massive insoluble, durable complex. The unlinked tropoelastin molecules are not normally available in the cell, since they become crosslinked into elastin fibres immediately after their synthesis by the cell and during their export into the extracellular matrix. Each tropoelastin consists of a string of 36 small domains, each weighing about 2 kDa in a random coil conformation. The protein consists of alternating hydrophobic and hydrophilic domains, which are encoded by separate exons, so that the domain structure of tropoelastin reflects the exon organization of the gene. The hydrophilic domains contain Lys-Ala (KA) and Lys-Pro (KP) motifs that are involved in crosslinking during the formation of mature elastin. In the KA domains, lysine residues occur as pairs or triplets separated by two or three alanine residues (e.g. AAAKAAKAA) whereas in KP domains the lysine ...
Pathologists have long observed that early stages of human vascular calcification occur along the edges and frayed ends of elastin fibers.52 As noted earlier, elastin haploinsufficiency reduces the vascular calcification associated with MGP deficiency in mice.39 The authors interpreted this finding to mean that MGP either protects mineralization initiation sites on elastin or alters extracellular matrix. These findings suggest that, in the context of MGP insufficiency, elastin calcification is metabolic in origin and that metabolic mineralization may lead to osteochondrogenic differentiation. Results showed a reduction in calcification and an increase in life span.39 The potential importance of elastin in other forms of vascular calcification is supported by its role as the target of calcification in the hereditary human disease, pseudoxanthoma elasticum (PXE), described below.. Clues about the role of elastin in metabolic vascular calcification come from the hereditary human disorder, PXE, ...
Although TGF-β blockade has shown benefit in MFS mouse models,2 the exact mechanisms through which TGF-β signaling leads to aneurysm development remain ill-defined. In this study, using Fbn1C1039G/+ mice, we have demonstrated that: (1) aortic root dilation forms as early as 2 weeks of age; (2) miR-29b expression is increased in Marfan AS aorta during early aneurysm development; (3) enhanced TGF-β signaling in the aortic wall of Fbn1C1039G/+ mice may serve to reduce active NF-κB, thereby causing a derepression of miR-29b; (4) treatment with a miR-29b oligonucleotide inhibitor prevents early aneurysm formation in Marfan mice; and (5) Marfan aortic aneurysm development is most closely associated with reduced elastogenesis and increased elastin fragmentation.. Here, we report for the first time to our knowledge that miR-29b plays an important role in early aneurysm formation in a Marfan mouse model. The miR-29b expression was significantly increased in the AS aorta, but not in the D or ABD ...
Abdominal aortic aneurysm (AAA) is an inflammatory disease associated with macrophage accumulation in the adventitia, oxidative stress, medial elastin degradation and aortic dilation. Progression of AAA is linked to increased risk of rupture, which carries a high mortality rate. Drug therapies trialled to date lack efficacy and although aneurysm repair is available for patients with large aneurysm, peri-surgical morbidity and mortality have been widely reported. Recent studies using rodent models of AAA suggest that long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) and their metabolites can moderate inflammation and oxidative stress perpetuated by infiltrating macrophages and intervene in the destruction of medial elastin. This review examines evidence from these animal studies and related reports of inhibition of inflammation and arrest of aneurysm development following prophylactic supplementation with LC n-3 PUFAs. The efficacy of LC n-3 PUFAs for management of existing aneurysm is
Whole bovine nuchal ligaments, or portions thereof (in the case of commercially valuable animals), were obtained from 45 animals (28 fetal and 17 postnatal) ranging in age from 110 days of gestation to 10 yr. Insoluble elastin was quantitatively prepared from the fresh ligaments by extraction with hot alkali and by a combination of multiple extractions with alkaline buffer and then repeated autoclaving. When adult samples were examined, the yields of insoluble residue by these two methods were very similar, but with young fetal samples the second method gave significantly higher values, because of incomplete purification of the elastin residue. The changes in the concentration of collagen, alkali-insoluble elastin, and DNA have been examined. DNA concentration, and, thus, cell population density, fell progressively during the fetal period of development, to reach a steady value soon after birth. Collagen appeared in appreciable quantities before elastin, but its concentration was rapidly halved ...
Recent Citation Employing the Sircol Assay. Venkatadri,R., Iyer,A.K.V., Ramesh,V., Wright,C., Castro,C.A., Yakisich,J.S. and Azad,N. (2017) MnTBAP Inhibits Bleomycin-Induced Pulmonary Fibrosis by Regulating VEGF and Wnt Signaling. Journal of Cellular Physiology 232, 506 - 516.. Recent Citation Employing the Blyscan Assay. Xue,L., Zhang,X., Niu,G., Yang,B. and Zhang,Y. (2017) Characterization of Sodium Dodecyl Sulfate Decellularized Cow Diaphragmatic Tendon Extracellular Matrix as Sling Biomaterial in Stress Urinary Incontinence Treatment. Journal of Biomaterials and Tissue Engineering 7, 83 - 89.. Recent Citation Employing the Fastin Assay. Kim,J.D., Jung,Y.J., Woo,C.H., Choi,Y.C., Choi,J.S. and Cho,Y.W. (2017) Thermo-responsive human α-elastin self-assembled nanoparticles for protein delivery. Colloids and Surfaces B: Biointerfaces 149, 122 - 129.. https://www.ncbi.nlm.nih.gov/pubmed/27744209. Recent Citation Employing the Apopercentage Assay. Uğuz,A.C., Öz,A. and Naziroğlu,M. (2016) ...
The transformation from carcinoma in situ to invasive carcinoma occurs when tumor cells traverse extracellular matracies allowing them to move into parenchymal tissues. Tumor invasion may be aided by the secretion of collagen and elastin degrading proteases from tumor and tumor-associated cells. In this study ~ the production of Type I and Type V collagen degrading activities and elastolytic activities by DLD-1 human colon carcinoma cells, B16-F10 murine melanoma cells, and normal human dermal fibroblasts was examined. DLD-1 cells and normal fibroblasts produced similarly high levels of collagenolytic activity. DLD-1 cells also produced high levels of elastinolytic activity; this activity was found exclusively in the extracellular medium. DLD-1 cells and normal fibroblasts produced more collagen and elastin degrading activity than did B16-F10 melanoma cells, a cell line characterized as highly metastatic. The Type I and Type V collagenolytic activities from DLD-1 cells were separated and characterized
MalaCards based summary : Mid-Dermal Elastolysis is related to pseudoxanthoma elasticum-like papillary dermal elastolysis and cutis laxa. An important gene associated with Mid-Dermal Elastolysis is ELN (Elastin), and among its related pathways/superpathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. Affiliated tissues include t cells, thyroid and skin, and related phenotypes are cardiovascular system and homeostasis/metabolism ...
Not only are connective tissues assigned different roles, they are made from different organic components that respond in a different way when cooked. The two most common organic components found in connective tissues are proteins called elastin and collagen. Elastin is a protein that forms the silverskin and ligaments in a cut of meat. It is what we would consider the gristle part on a steak or other cut of meat. Regardless of cooking method or approach, gristle will always be tough and chewy as a result of the elastin proteins. For this reason, it is common practice to remove as much elastin connective tissue, or gristle, from a cut of meat before its cooked.. Collagen is another common protein found in meat. It is responsible for sheathing the elongated muscle fibers that make up a cut of meat. You see, meat is made of these long muscle fibers, and each individual one is encased in coat of collagen. Furthermore, these elongated muscle fibers are bunched together to form larger muscle ...
Internal supplementation can help strengthen and support tendons and ligaments by giving them proper minerals and nutrients they need to maintain strong and healthy tissues. Precision Joint Solution Plus was formulated to target not only the joints but the surrounding structures including cartilage, tendons, and ligaments. Our patent pending ingredients are designed to provide the needed collagen, elastin proteins, HA and other necessary materials to support, strengthen and increase healing of the joint matrix and surrounding soft tissue.. Tendons and ligaments are made up of elastins and collagen. Elastin is a protein in connective tissue that is well… elastic! It allows the many tissues in the body to resume their shape after stretching or contracting. Collagen is the main supportive protein of cartilage, connective tissue, tendon, skin, and bone. Precisions first key ingredient Biovaflex, which contains an incredible form of elastin and collagen. Feeding this highly digestible ...
TY - JOUR. T1 - Elastin Organization in Pig and Cardiovascular Disease Patients Pericardial Resistance Arteries. AU - Bloksgaard, Maria. AU - Leurgans, Thomas M.. AU - Nissen, Inger. AU - Jensen, Pia Sondergaard. AU - Hansen, Maria Lyck. AU - Brewer, Jonathan R.. AU - Bagatolli, Luis A.. AU - Marcussen, Niels. AU - Irmukhamedov, Akhmadjon. AU - Rasmussen, Lars Melholt. AU - De Mey, Jo G. R.. PY - 2015. Y1 - 2015. KW - Elastin. KW - Collagen. KW - Remodeling. KW - Extracellular matrix. KW - Two-photon excitation fluorescence microscopy. U2 - 10.1159/000376548. DO - 10.1159/000376548. M3 - Article. VL - 52. SP - 1. EP - 11. JO - Journal of Vascular Research. JF - Journal of Vascular Research. SN - 1018-1172. IS - 1. ER - ...
I have addressed this topic, but not at Thunders. Elasticity is caused by a substance called elastin - a very springy molecule, as one would expect. It causes the connective tissue matrix of your skin to recoil after it has stretched. Plasticity is the ability of the connective tissue matrix to undergo a permanent change, and involves changes to collagen, principally.. I floated a hypothesis several years ago: in order for collagen damage to occur, one would have to load the elastin network until it had reached maximal extension (hanging is a perfect example of how to achieve this), but I have since backed off from this extreme view. I think that plasticity can occur under lighter loads, and not necessarily from damaging collagen at all.. The matrices of the penile fascia (Bucks, tunicas, et cetera) are composed of, on average, 5% elastin. This allows the penis to have a passive recoil as the volume (not pressure) of blood in the corpora decreases. Guys with more elastin (like me, ...
Consumption of excess fat and carbohydrate (Western diet, WD) is associated with alterations in the structural characteristics of blood vessels. This vascular remodeling contributes to the development of cardiovascular disease, particularly as it affects conduit and resistance arteries. Vascular remodeling is often associated with changes in the elastin-rich internal elastic lamina (IEL) and the activation of transforming growth factor (TGF)-β. In addition, obesity and type II diabetes have been associated with increased serum neuraminidase, an enzyme known to increase TGF- β cellular output. Therefore, we hypothesized that WD-feeding would induce structural modifications to the IEL of mesenteric resistance arteries in mice, and that these changes would be associated with increased levels of circulating neuraminidase and the up-regulation of elastin and TGF-β in the arterial wall. To test this hypothesis, a WD, high in fat and sugar, was used to induce obesity in mice, and the effect of this diet on
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Due to hormonal changes we all experience as we age, our skin will progressively lose its collagen and elastin proteins. Elastin proteins and collagen are essential and give your skin its structure, ability to stretch, and overall skin strengthening. Further, Collagen is one of the primary building blocks of bones, skin, muscles, tendons, and ligaments. Hence why the older you get, the more your skin begins to sag and wrinkle. As breasts are made of these same essential proteins, we find that many women experience some level of sagging and stretching in their breasts as they age. Many other contributing factors include weight gain, weight loss, pregnancy, and breastfeeding. Fortunately, we now live in a time where we have the expertise and technology that can improve the appearance of breasts and eliminate any troublesome issues associated with the natural aging process and life experiences. Keep reading for a breakdown on everything you need to know about breast lift procedures to help you ...
The effect of serum deprivation on proliferating cells is well known, in contrast its role on primary cell cultures, at confluence, has not been deeply investigated. Therefore, in order to explore the response of quiescent cells to serum deprivation, ubiquitous mesenchymal cells, as normal human dermal fibroblasts, were grown, for 48 h after confluence, in the presence or absence of 10% FBS. Fibroblast behaviour (i.e. cell morphology, cell viability, ROS production and elastin synthesis) was evaluated morphologically and biochemically. Moreover, the protein profile was investigated by 2-DE and differentially expressed proteins were identified by MS. Serum withdrawal caused cell shrinkage but did not significantly modify the total cell number. ROS production, as evaluated by the dihydroethidium (DH2) probe, was increased after serum deprivation, whereas elastin synthesis, measured by a colorimetric method, was markedly reduced in the absence of serum. By proteome analysis, 41 proteins appeared to ...
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For the first time, calorimetric studies performed at very low temperature highlighted the preliminary and required conditions for further aggregation/coacervation of peptides from elastin in solution through the structural water reorganization around the peptides. For this purpose, we firstly characterized by turbidimetry and differential scanning calorimetry the synthetic S4 fragment peptide containing the XGGZG motif (where X and Z correspond to Valine or Leucine) which is able to form amyloid fibres under certain conditions. We also investigated two mediumsized elastin-related model elastin peptides containing the VGVPG motif (E50 and E18) as well as their analogues where proline is hydroxylated in hydroxyproline. These peptides were shown to coacervate, and a close correlation was found between the inverse transition temperature obtained by turbidimetry and the clathrate-like structures evidenced at low temperature by the calorimetric method. ...
Liberation of elastin peptides from damaged lung may be a mechanism of autoimmune lung disease. Citrullination, and anti-citrullinated protein antibody formation occurs in smokers, but the role of smoking in autoantibody generation relevant to pulmonary disease is unclear. Anti-elastin, anti CCP and anti-MCV antibodies were measured in 257 subjects with alpha 1 antitrypsin deficiency (AATD) , 113 subjects with usual COPD and 22 healthy non-smokers. Levels were compared between groups, against phenotypic features, and against smoke exposure. Anti-elastin antibodies were higher in controls relative to AATD (p=0.008) and usual COPD ( ...
St. Ives Facial Moisturizer, Timeless Skin Collagen Elastin, 10oz One, 10-ounce jar of St. Ives Timeless Skin Collagen Elastin Facial Moisturizer Formulated to minimize the appearance of fine lines plus keep the youthful appearance Made with collagen plus elastin proteins Hydrates for visibly softer, smoother skin St. Ives formulations employ powerful, all-natural elements for fresher, […]. Read More... ...
TY - JOUR. T1 - Detection of an atypical 7q11.23 deletion in Williams syndrome patients which does not include the STX1A and FZD3 genes. AU - Botta, A.. AU - Novelli, G.. AU - Mari, A.. AU - Novelli, A.. AU - Sabani, M.. AU - Korenberg, J.. AU - Osborne, L. R.. AU - Digilio, M. C.. AU - Giannotti, A.. AU - Dallapiccola, B.. PY - 1999. Y1 - 1999. N2 - We present two patients with the full Williams syndrome (WS) phenotype carrying a smaller deletion than typically observed. The deleted region spans from the elastin gene to marker D7S1870. This observation narrows the minimal region of deletion in WS and suggests that the syntaxin 1A and frizzled genes are not responsible for the major features of this developmental disorder and provides important insight into understanding the genotype-phenotype correlation in WS.. AB - We present two patients with the full Williams syndrome (WS) phenotype carrying a smaller deletion than typically observed. The deleted region spans from the elastin gene to marker ...
Williams syndrome is caused by the deletion of 1.5-1.8 megabases (measurement of length) of genetic material at chromosome 7q11.23. Although there are several genes included in the deleted region of chromosome 7, no single gene has been identified as causing Williams syndrome.. Genes that are typically deleted include; Elastin, LIMK1, CLIP2, GTF2IRD1 AND GTF2I. Elastin is missing in 95-99% of individuals with Williams syndrome and therefore is the main gene used to genetically diagnose Williams syndrome. Elastin is a protein found in connective tissue which is important for connecting organs and tissues, and for storing nutrients. The loss of elastin is associated with connective tissue abnormalities and cardiovascular (heart) disease.. Download this page as a PDF. ...
The discovery of biomimetic polypeptides that enable the biomineralization of synthetic and biosynthetic materials has resulted in the development of hybrid materials that incorporate inorganic components for potential application in drug delivery, enzyme immobilization, and surface modification. Here, we de
Before we discuss some specific ingredients, it is important that we understand a little about how the skin ages and what type of product will be effective in reversing the signs of aging.. The main reason the skin starts to sag and/or form wrinkles is that elastin and collagen start to break down. Elastin is a protein that helps the skin stay supple and firm. When your skin is stretched, it is the elastin that returns it to its normal position.. Collagen is a fibrous protein. Collagen is special among proteins because of its great tensile strength providing firmness to the skin. Over time, our bodies produce less of the proteins collagen and elastin. Without them, the skin loses its elasticity, starts to sag and form wrinkles. This is why it is important to use ingredients effective at firming skin. Exposure to the sun also causes changes in collagen fibers thatlead to wrinkles and lines. Air pollution increases the production offree radicals, which further damage collagen fibers.. There are ...
Auch wenn dieser St ives skincare uk eventuell einen höheren Preis als seine Konkurrenten hat, spiegelt sich dieser Preis auf jeden Fall in den Aspekten langer Haltbarkeit und sehr guter Qualität wider. In this article we suggest top 10 the. £14.73. For skin that needs a little rejuvenation, our Renewing Collagen & Elastin Body Lotion will reawaken your glow. bei Amazon.de , Günstiger Preis , Kostenloser Versand ab 29€ für ausgewählte Artikel St. Ives Skin Renewing Body Lotion with Collagen Elastin 26.2 Fl oz. St ives skincare uk - Bewundern Sie dem Testsieger der Experten. Unsere Redakteure begrüßen Sie als Kunde auf unserer Webpräsenz. This is a test review. I have tried almost every possible lotion and cream on the market to treat this disease and St Ives Collagen Elastin for Severely Dry Skin is the best treatment I have come across thus far. Get free shipping at $35 and view promotions and reviews for St. Ives Renewing Body Lotion Collagen Elastin Um Ihnen als Kunde die Wahl des ...
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Collagen, elastin, and hyaluronic acid are the essential building blocks of skin. The break down of these building blocks cause the visible signs of aging.
Neuman, R.E. and Logan, M.A. (1950) Determination of Collagen and Elastin in Tissues. The Journal of Biological Chemistry, 186, 549-556.
Pure + simple Collagen Elastin Plus available at Pure + simple Toronto. The best selling anti aging serum to reduce signs of aging skin from fine lines, hyperpigmentation + large pores.
Product Page for Tres Beauty 3 (Collagen, Keratin & Elastin) 90 Caps made by reserveage-nutrition offering price, ingredients and full item description from betterlife
A bőr elaszticitását, hidratáltságát növelő hatóanyag koncentrátum, mely bármely kezelésbe beilleszthető. Közvetlenül bőrön nem alkalmazható! Adagolás: 10-15 csepp gélbe vagy krémbe. Ingredients: Aqua, Soluble Collagen, Hydrolized Elastin, Hexylene Glycol & Fructose & Glucose & Sucrose & Urea &
Aloe Moisturizing Lotion enthält pflegendes, regenerierendes Elastin und Collagen, hautpflegende Öle aus Jojoba und Aprikosenkernen und Kamillenextrakt.
Luminance™ contains our proprietary skin tightening ingredient - Flavinall™ which provides an immediate skin tighening effect and the results improve with continued use.. Flavinall™ is an extraction of protein peptides, flavinoids, integrins (they help hold everythng together), vitamins, minerals and antioxidants from fresh vegan organic foods. These nutrients are small enough to be utilized by the skin cells to help repair and renew broken and degraded collagen and elastin fibers.. The immediate tightening effect Flavinal provides instantly improves the appearance around the eye.. With Continued Use The Results Are Spectacular.... The area around the eye is usually the first visible signs of aging for most people.. Its the result of the eyes blinking an average of over 10,000 times per day. Such repetitive expansion and contraction of the skin causes the collagen and elastin fibers around the eye to break down faster than on other parts of the body.. Dark circles under the eyes are caused ...
-A revolutionary firming & repairing treatment-Features a bio-microemulsified lightweight gel texture that is easily absorbed by skin-Formulated with Marine Elastin to improve elasticity of skin-Blended with Jasmine Oil for moisturizing & healing benefits-Loaded with Sorghum to improve texture & enhance skin firmness-Effectively combats premature signs of aging-Unveils a smoother brighter more lifted & younger looking complexionProduct Line: Night CareProduct Size: 30ml/1oz
- Using liposome capsule process for each nutritious ingredient without damages, it deeply delivers nutrition into the skin. - It acts as a detoxification, to remove potentially toxic substances. - Age decelerating cream; Anti-aging and dryness. An effective cream for pimple /acne skin. - With Salmon extract elastin, it is an excellent in skin affinity and extremely absorbent. Experience the feeling of soft and fresh skin. - It is a creamy moisturizer cream with ample nutrition. It will change the dry skin into smooth and emollient one. - It makes clean skin by removing the toxin from underneath the skin. - Ample application to the thin and weak skin around the eyes will remove the dryness and wrinkle. - Can be used as an eye cream. Volume: 50ml
- Using liposome capsule process for each nutritious ingredient without damages, it deeply delivers nutrition into the skin. - It acts as a detoxification, to remove potentially toxic substances. - Age decelerating cream; Anti-aging and dryness. An effective cream for pimple /acne skin. - With Salmon extract elastin, it is an excellent in skin affinity and extremely absorbent. Experience the feeling of soft and fresh skin. - It is a creamy moisturizer cream with ample nutrition. It will change the dry skin into smooth and emollient one. - It makes clean skin by removing the toxin from underneath the skin. - Ample application to the thin and weak skin around the eyes will remove the dryness and wrinkle. - Can be used as an eye cream. Volume: 50ml
Elastin Products Company, Inc. (EPC) warrants that its products are merchantable quality and warrants the accuracy of its description of such products. EPC warrants that the products described herein has performed as disclosed by EPC. Purchaser must determine suitability of the product for any unusual or particular purpose. THIS WARRANTY IS EXCLUSIVE AND EPC MAKES NO OTHER WARRANTY, EXPRESSED OR IMPLIED, THAT THE PRODUCT DESCRIBED HEREIN IS MERCHANTABLE OR FIT FOR ANY PARTICULAR PURPOSE. Whenever any items(s) leaves our premises, such items(s) are absolutely out of our control. EPC therefore makes no warranty as to fitness for any particular purpose or to protection against patent, copyright and trade mark infrigement. In any and all situations it is the total responsibility of the buyer and/or user to determine any and all possible patent, copyright and trade.. ...
Elastin Products Company, Inc. (EPC) warrants that its products are merchantable quality and warrants the accuracy of its description of such products. EPC warrants that the products described herein has performed as disclosed by EPC. Purchaser must determine suitability of the product for any unusual or particular purpose. THIS WARRANTY IS EXCLUSIVE AND EPC MAKES NO OTHER WARRANTY, EXPRESSED OR IMPLIED, THAT THE PRODUCT DESCRIBED HEREIN IS MERCHANTABLE OR FIT FOR ANY PARTICULAR PURPOSE. Whenever any items(s) leaves our premises, such items(s) are absolutely out of our control. EPC therefore makes no warranty as to fitness for any particular purpose or to protection against patent, copyright and trade mark infrigement. In any and all situations it is the total responsibility of the buyer and/or user to determine any and all possible patent, copyright and trade.. ...
Valmont Elastin & Prime Anti-Wrinkle & Firming Dermo-Structuring Master Factor 3 50ml - The synergetic action of 30% more Prime AWF complex, along with soy phytosterols and wild yam contribute to improving the signs of ageing. Ideal for skins that are sagging and marked by wrinkles
RGD (arginine-glycine-aspartic) containing elastin-like proteins (RGD-ELP), in the structure of TGPG[VGRGD (VGVPG)6]20WPC, was treated to HEK293 cells to construct in vivo-mimic 3-dimensional (3D) spheroid cells. The constructed 3D cells had increased extracellular matrices (ECMs). To identify the induced functions of 3D cells with ECMs, genomic profiles changed in 3D cells compared to the conventional 2-dimensional (2D) cells were analyzed. In HEK293 cells exposed RGD-ELP for 72 h, the total up- and down-regulated genes (824 genes) were selected to be differentially expressed genes. Further analysis by bioinformatics showed that top functions induced in 3D cells were cell proliferation, cell-to-cell signaling, cell differentiation and movement, and connective tissue development and function. We propose that the 3D cells constructed with RGD-ELP in this study could provide more in vivo-mimic responses by cell-to-cell and cell-to-ECM signaling. © 2013 Korean Society of Environmental Risk ...
In addition to stimulating the production of collagen and elastin, copper peptides promote the production of glycosaminoglycans like hyaluronic acid. Glycosaminoglycans are found in the connective tissue and fluids in the human body and are largely responsible for keeping skin plump, supple and in the case of hyaluronic acid, hydrated. Whether or not copper peptides are safe has been debated, but since these compounds occur naturally, experts suggest that if you experience any irritation after using a product containing copper peptides, then you are more than likely sensitive to something else in the ingredient list. Further, clinical research has proven that copper peptides are antioxidants that fight against free radical damage, which is another major contributing factor to aging.. Using a product that contains copper peptides is a great way to fight against the signs of aging like fine lines and wrinkles. These naturally occurring compounds boost collagen and elastin production and stimulate ...
Acellular matrix grafts are provided with are isolated from natural sources and consist essentially of a collagen and elastin matrix which is devoid of cellular components. The grafts are useful scaffolds which promote the regeneration of muscle tissue and aid in restoring muscle function. Due to their acellular nature, the grafts lack antigenicity. As a result, the acellular matrix grafts can be isolated from autographic, allographic or xenographic tissues.
... and these tissues contain high amounts of elastins. Elastins are synthesized by fibroblasts and smooth muscle cells. Elastins ... Elastin[edit]. Elastins, in contrast to collagens, give elasticity to tissues, allowing them to stretch when needed and then ... Disorders such as cutis laxa and Williams syndrome are associated with deficient or absent elastin fibers in the ECM.[9] ... This property is primarily dependent on collagen and elastin concentration,[2] and it has recently been shown to play an ...
... helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing ... "Elastin (ELN)". Retrieved 31 October 2011.. *^ Muiznieks LD, Weiss AS, Keeley FW (Apr 2010). "Structural disorder and dynamics ... Elastin is also very important in the lungs, elastic ligaments, elastic cartilage, the skin, and the bladder. It is present in ... Elastin is a highly elastic protein in connective tissue and allows many tissues in the body to resume their shape after ...
Maintenance of crosslinked elastin is carried out by a number of proteins including lysyl oxidase-like 1 protein. Mature ... Elastic fibers include elastin, elaunin and oxytalan. Elastic tissue is classified as "connective tissue proper". Elastic ... Cutis laxa and Williams syndrome have elastic matrix defects that have been directly associated with alterations in the elastin ... Schräder CU, Heinz A, Majovsky P, Karaman Mayack B, Brinckmann J, Sippl W, Schmelzer CE (September 2018). "Elastin is ...
Elastin is the key protein of the extracellular matrix and is the main component of the elastic fibres. Elastin gives the ... Elastin is more concentrated in areas of high stress such as the openings of the alveoli, and alveolar junctions. The ... Elastase breaks down the elastin in the lung's connective tissue that can also result in emphysema. Elastase is inhibited by ... Mithieux, Suzanne M.; Weiss, Anthony S. (2005). "Elastin". Fibrous Proteins: Coiled-Coils, Collagen and Elastomers. Advances in ...
Ladislas Robert (1989). Elastin and elastases. Boca Raton, Fla.: CRC Pr. ISBN 0-8493-6429-9.CS1 maint: extra text: authors list ...
Elastin fibers stain dark purple/black with Verhoeff's stain. The extracellular matrix contains Elastin, fibrillin, ... Elastic fibers within the extracellular matrix are made up of elastin proteins which co-polymerize with fibrillin forming fiber ... The principal protein is elastin. Elastic cartilage is histologically similar to hyaline cartilage but contains many yellow ...
Elastic microfibril and elastin. extracellular matrix Reticular fibers. Form a scaffolding for other cells. Type III collagen. ... made from elastin and fibrillin, also provide resistance to stretch forces.[16]:171 They are found in the walls of large blood ...
Elastin microfibril interfacer 1 (EMILIN-1) is a protein that in humans is encoded by the EMILIN1 gene. It is the best ... "Entrez Gene: EMILIN1 elastin microfibril interfacer 1". CS1 maint: discouraged parameter (link) Doliana R, Mongiat M, Bucciotti ... 2000). "Structure, chromosomal localization, and promoter analysis of the human elastin microfibril interfase located proteIN ( ...
The enzyme degrades soluble and insoluble elastin. The gene is part of a cluster of MMP genes which localize to chromosome ...
elastin: a vertebrate protein Deming T (2012). Peptide-Based Materials. Springer Publishing. Neurath H (1966). The Proteins ... The PPII structure widely exists in elastomeric proteins, such as abductin, elastin, and titin. It is believed to contribute in ... Rubber like proteins, such as resilin and elastin, are characterized based on their high resilience, low stiffness, and large ...
Substrates include elastin, fibronectin, Col IV MMP13. Collagenase 3. CLG3, MANDP1, MMP-13. secreted. Substrates include Col I ... Substrates include Col IV, laminin, fibronectin, elastin MMP11. Stromelysin 3. SL-3, ST3, STMY3. secreted. MMP-11 shows more ...
... is a lysine derivative found in elastin. Isodesmosine is an isomeric pyridinium-based amino acid resulting from ... These represent ideal biomarkers for monitoring elastin turnover because these special cross-links are only found in mature ... elastin in mammals. Desmosine Miao, M.; Bruce, A.E.E.; Bhanji, T.; Davis, E.C.; Keeley, F.W. (2007). "Differential expression ... the condensation of four lysine residues between elastin proteins by lysyl-oxidase. ...
PMID 19714629.(cited 29 times) Nettles, DL; Chilkoti, A; Setton, LA (2010). "Applications of elastin-like polypeptides in ... "In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect ... "Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide". Biomaterials. 27 (1): 91- ... "Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 ...
The main structural proteins are collagen and elastin. This causes thinning and the wall balloons allowing gross enlargement to ...
Degradation of elastin, starch and casein is positive. Strains SPS-243T, RQ-10 and RQ-12 utilize D-glucose, D-fructose, D- ...
"Quantitative Observation of Backbone Disorder in Native Elastin". Journal of Biological Chemistry. 279 (9): 7982-7. doi:10.1074 ...
They concluded with relative certainty that the pyridine cross-links found in elastin were, in fact, due to an in-vivo ... Umeda, H.; Takeuchi, M.; Suyam, K. (2001). "Two New Elastin Cross-links Having Pyridine Skeleton". Journal of Biological ... Researchers found that protein-incorporated allysine, (deaminated lysine) from bovine ligamentum nuchae elastin fibers appeared ... Extrapolating from an in-vitro elastin model under physiological conditions, the researchers found that the ratios of IDP to ...
It consists of loose connective tissue and elastin. The main cell types are fibroblasts, macrophages and adipocytes (the ...
"프리스틴 (PRISTIN) - HI! PRISTIN (The 1st Mini Album) [Ver B. Elastin]". 리스뮤직 (in Korean). Retrieved 2017-08-30. "[팝's신곡]"파워 & 프리티 ... Physically, the album received two versions, Prismatic and Elastin, the words that originated the name Pristin. The first ...
... is associated with deficient or absent elastin fibers in the extracellular matrix. This can be related to decreased ... It has also been considered that mutations in elastin (ELN) and fibulin-5 (FBLN5) genes can increase susceptibility of elastic ... 2016-02-13). "Acquired Localized Cutis Laxa due to Increased Elastin Turnover". Case Reports in Dermatology. 8 (1): 42-51. doi: ... 2016-02-13). "Acquired Localized Cutis Laxa due to Increased Elastin Turnover". Case Reports in Dermatology. 8 (1): 42-51. doi: ...
The elastin receptor complex includes S-Gal, neuraminidase and Cathepsin A. When elastin-derived peptides bind to the S-Gal ... The S-Gal protein does bind elastin and fragments of elastin that are generated by proteolysis. The S-Gal protein is a ... The ability of the GLB1-derived elastin binding protein and the elastin receptor complex to influence cell proliferation ... The S-Gal protein functions during the normal assembly of elastin into extracellular elastic fibers. Elastin is initially ...
The elastin on the other hand is a protein that allows for flexibility. These two elements of the nuchal ligament maintain a ... The yellow colour is the elastin on the ligaments.) The name is derived from the corruption of paxwax (originally faxwax Old ... the nuchal ligament is formed with the association of both elastin proteins as well as type III collagen (45%). The collagen ...
Bristow J, Carey W, Egging D, Schalkwijk J (2005). "Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome". Am J Med ...
The process of coacervation is thought to be essential for proper elastin assembly in the ECM. Coacervation must occur outside ... Epidermal samples from the same patient subjected to electron microscopy revealed that elastin fibers display abnormally high ... The skin's elastic fiber system consists of elastin (which is normally non-glycosylated) and glycosylated proteins (fibulin, ... Elastin is not required for brain or bone growth. However, it is believed that abnormal/impaired secretion of the brain and ...
The human lung contains large quantities of collagen and elastin, proteins that allow for tissue flexibility. Aspergillus ... Rosenbloom J (December 1984). "Elastin: relation of protein and gene structure to disease". Laboratory Investigation; A Journal ... fumigatus produces and secretes elastases, proteases that cleave elastin in order to break down these macromolecular polymers ...
Bristow J, Carey W, Egging D, Schalkwijk J (2005). "Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome". American ... Goepel C (2008). "Differential elastin and tenascin immunolabeling in the uterosacral ligaments in postmenopausal women with ...
Elastin-like polypeptides (ELPs) are a useful tool in biotechnology. Fused with target protein, they tend to form aggregates ...
Sheldon Hendler on IMDB Kornberg, RL; Hendler, SS; Oikarinen, AI; Matsuoka, LY; Uitto, J. "Elastoderma--disease of elastin ...
Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing ... "Elastin (ELN)". Retrieved 31 October 2011.. *^ Muiznieks LD, Weiss AS, Keeley FW (Apr 2010). "Structural disorder and dynamics ... Elastin is also very important in the lungs, elastic ligaments, elastic cartilage, the skin, and the bladder. It is present in ... Elastin is a highly elastic protein in connective tissue and allows many tissues in the body to resume their shape after ...
elastin* A fibrous protein that is the major constituent of the yellow elastic fibres of connective tissue [1]. It is rich in ... elastin A fibrous protein that is the major constituent of the yellow elastic fibres of connective tissue. It is rich in ... elastin A Dictionary of Food and Nutrition © A Dictionary of Food and Nutrition 2005, originally published by Oxford University ... elastin Insoluble protein in connective tissue, which is not affected by cooking; the cause of tough meat.. ...
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
Elastin is a rubber,rubberlike protein with fibres that can stretch to many times their normal length. It is a highly ... Elastin is a rubberlike protein with fibres that can stretch to many times their normal length. It is a highly hydrophobic ... Elastin networks in the extracellular matrix are essential for the functioning of such organs as lungs, skin and blood vessels ... Elastin is predominantly composed of small, non-polar amino acids, with the smallest of the amino acids, Glycine making up one ...
Reviva Labs, Elastin Collagen Body Firming Lotion, 8 fl oz (236 ml). ...
Elastin-like polypeptides (ELPs) are synthetic biopolymers with potential applications in the fields of cancer therapy, tissue ... Tropoelastin is a protein, of size 72kDa, that comes together via cross-links to form elastin in the extracellular matrix of ... One of the major reasons that elastin can withstand high levels of stress in the body without experiencing any physical ... March 2015). "Fabricated Elastin." Advanced Healthcare Materials. 4(16): 2530-2556. Retrieved 15 May 2017. Christensen, T; ...
The degradation of elastin by elastase-type enzymes was shown to play an important role in several pathological processes such ... are able to hydrolyze elastin and release soluble peptides. The released peptides (mainly kappa elastin, KE) were shown to have ... The degradation of elastin by elastase-type enzymes was shown to play an important role in several pathological processes such ... Rabbits immunized with elastin peptides were shown to develop severe arteriosclerosis (Robertet al., 1971; Jacobet al., 1984) ...
Pulmonary Emphysema Entire Lung Leukocyte Elastase Pancreatic Elastase Elastin Content These keywords were added by machine and ... Mandl I., Darnule T.V., Fierer J.A., Keller S., Turino G.M. (1977) Elastin Degradation in Human and Experimental Emphysema. In ... Work in progress is designed to distinguish the peptides resulting from digestion of human lung elastin by these enzymes on the ... In support of this mechanism we show (1) by biochemical analysis - that elastin content of connective tissue has been decreased ...
Research in elastin preservation and regeneration may be the key to future longevity.. Dr. Vyavahare is a Hunter Endowed Chair ...
News-Medical.Net provides this medical information service in accordance with these terms and conditions. Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. ...
Restoring Elastin In Skin Isnt As Hard As You Might Think - Provided You Use The Right Ingredients. 17th June 2009 ... Natural Skincare Ingredients Can Re-Build Collagen And Elastin. 13th February 2009 ...
... Antonietta Pepe,1 Florian Delaunay,1,2 Angelo Bracalello,1 and ... In this report, we will investigate in vitro the inhibitory effect of resveratrol on elastin amyloidogenesis. The effect of ... Elastin is the extracellular protein responsible for elasticity in vertebrates. Its production occurs during the early neonatal ... S. Baud, L. Duca, B. Bochicchio et al., "Elastin peptides in aging and pathological conditions," Biomolecular Concepts, vol. 4 ...
Why We (Love) Collagen & Elastin: Collagen and elastin proteins are naturally present in healthy skin. Support these key ... Body Lotion, Renewing, Collagen & Elastin St. Ives Body Lotion, Renewing, Collagen & Elastin 00077043608029 ...
Elastin and Elastases in Lung Disease. Elastin and Elastases in the Pathology of the Arterial Wall. Elastin and Elastic Fibers ... Elastin in Human Breast Tumors. Neosynthesis of Elastin in Response to Vascular Injury. The Temporal Arteritis/Polymyalgia ... these volumes systematically present many topics in the elastin and elastases fields. Volume I explains elastin, its ... Mechanisms Involved in Elastin-Elastase Interaction. Mechanism of Action of Elastases. ELASTASES: CHARACTERIZATION AND ...
Elastins persistence and insolubility hampered early efforts to construct versatile biomaterials. Subsequently the field has ... Elastin is a versatile elastic protein that dominates flexible tissues capable of recoil, and facilitates commensurate cell ... Elastin-based materials† Jessica F. Almine,a Daniel V. Bax,a Suzanne M. Mithieux,a Lisa Nivison-Smith,a Jelena Rnjak,a Anna ... Subsequently the field has progressed substantially through the adapted use of solubilized elastin, elastin-based peptides. and ...
Elastin. Elastin (Elastin (Supravalvular aortic stenosis, Williams-Beuren syndrome), isoform CRA_l) (cDNA FLJ34913 fis, clone ... ElastinImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href="/ ... tr,E7EQH8,E7EQH8_HUMAN Elastin (Fragment) OS=Homo sapiens OX=9606 GN=ELN PE=1 SV=8 ...
Rabbit polyclonal alpha Elastin antibody. Validated in WB, IP, ELISA, IHC, ICC and tested in Mouse, Rabbit, Cow, Dog, Human. ... Signal Transduction Cytoskeleton / ECM Extracellular Matrix ECM Proteins Elastin Share by email ... Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the ... I can confirm that ab21607 alpha Elastin antibody has been tested and guaranteed for IHC-P and human and mouse samples. ...
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Buy June Jacobs Elastin Collagen Serum online at SkinStore with free shipping! We have a great range of June Jacobs Spa Skin ...
Rabbit polyclonal alpha Elastin antibody. Validated in WB, IP, ELISA, IHC, ICC and tested in Mouse, Rabbit, Cow, Dog, Human. ... Signal Transduction Cytoskeleton / ECM Extracellular Matrix ECM Proteins Elastin Share by email ... Primary - Rabbit Anti-alpha Elastin antibody (ab21607) ICC, ELISA, WB, IP, IHC-FoFr, IHC-P ... Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the ...
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Get free shipping at $35 and view promotions and reviews for Carson Life Collagen Elastin with Vitamin E Face Cream Lavender ... Carson Life Collagen Elastin with Vitamin E Face Cream Lavender at Walgreens. ... Carson Life Collagen Elastin with Vitamin E Face Cream Lavender4.0 oz. ... Active Ingredients: Collagen (Lexein 300) - 0.7 %, Elastin - 0.3 %, Vitamin E (As DL-Tocophenil Acetate) - 1.0 % ...
Verify. VERIFY helps distinguish between true and false information by answering questions directly from you. Looking for Connect content? Check out the sites footer.. ...
Collagen and elastin may be able to reduce the signs of aging, particularly wrinkling and sagging of the skin. Topical products ... marks, which leads me to believe she has a lot of elastin in her skin and that her sister and her Mom are probably the same way ... Collagen and elastin are naturally occurring structural proteins normally produced in the dermis, the middle layer of the skin ... I think having little elastin in my skin runs in my family because both my sister and I have had stretch marks since we became ...
The elastin receptor complex contains a component of 67 kilodaltons that binds to a glycoconjugate affinity column containing ... Since lactose also blocks elastic fiber formation by cultured chondroblasts, the galactoside-binding property of the elastin ... and its association with immobilized elastin is inhibited by lactose. ...
Elastin boosts elasticity & smoothes skin to reduce the look of wrinkles & fine lines. ... Explore the wrinkle-fighting benefits of skincare products with Elastin. ... Elastin Skin Benefits:. Anti-Wrinkle. Elasticity. Elastin is the second most abundant protein in the body. Elastins function ... In skincare, elastin products are most commonly found in the form of moisturizers (i.e. elastin cream). 1 ...
Browse fuzing.com to find Elastin Sports Tape sellers, suppliers, wholesalers, companies, manufacturers, exporters, factories. ... Elastin Sports Tape. You May Also Be Interested In: cotton fibres elastic adhesive tape sports tape The Elastin Sports Tape is ...
Ives Body Lotion, Skin Renewing Collagen Elastin (2014 formulation) for safety according to the methodology outlined in our ... Ives Body Lotion, Skin Renewing Collagen Elastin (2014 formulation). See all: Alberto-Culver ... Hydrolyzed Elastin, Butyrospermum Parkii (Shea) Butter, Dimethicone, PEG 100 Stearate, Cyclopentasiloxane, Triethanolamine, ...
The subject of the invention is an elastin-based product consisting of an adduct containing elastin and at least one protein ... Prosthetic devices including elastin or elastin-based materials. US6069129 *. 13 Mar 1998. 30 May 2000. Mrs, Llc. Elastin ... it is understood that the term elastin covers native or mature elastins, their derivatives and elastins modified, especially, ... Elastin and elastin-based materials. US6113636 *. 20 Nov 1997. 5 Sep 2000. St. Jude Medical, Inc.. Medical article with adhered ...
  • 1984), are able to hydrolyze elastin and release soluble peptides. (springer.com)
  • The released peptides (mainly kappa elastin, KE) were shown to have a variety of biological properties (Robert et al . (springer.com)
  • Rabbits immunized with elastin peptides were shown to develop severe arteriosclerosis (Robert et al . (springer.com)
  • 1987). Our aims were to investigate the effects of elastin peptides on ion fluxes and to elucidate their mechanism of action at the cellular and intracellular levels. (springer.com)
  • Work in progress is designed to distinguish the peptides resulting from digestion of human lung elastin by these enzymes on the basis of differences in their precipitating anti bodies. (springer.com)
  • Subsequently the field has progressed substantially through the adapted use of solubilized elastin, elastin-based peptides and the increasing availability of recombinant forms of the natural soluble elastin precursor, tropoelastin. (rsc.org)
  • Here we demonstrate the fabrication of a fusion protein comprising of elastin-like peptides and KGF. (pnas.org)
  • It also preserved the characteristic elastin-like peptides inverse phase transitioning allowing the recombinant protein to be expressed in bacterial hosts (such as Escherichia coli ) and purified rapidly and easily using inverse temperature cycling. (pnas.org)
  • This includes scaffolds of collagen and solubilized elastin ( 17 ), dermal substitutes coated with 3% α-elastin ( 6 , 18 ), and alginate wound dressings linked with hybrid peptides of elastin ( 19 ). (pnas.org)
  • Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway. (semanticscholar.org)
  • We studied the effects of elastin-derived peptides (EDPs), biomarkers of aging, on NAFLD progression. (diabetesjournals.org)
  • Migration of the chorioretinal endothelial cell line RF/6A in response to elastin peptides was assessed in the presence of inhibitors of two elastin receptors, ITGAV/ITGB3 and GLB1. (arvojournals.org)
  • Chorioretinal endothelial cells increase migration in the presence of elastin fragments and this response is inhibited by both GLB1 and ITGAV/ITGB3 antagonists, indicating that both proteins may be endothelial cell receptors for elastin peptides. (arvojournals.org)
  • Determining the mechanism by which elastin peptides bind to and activate choroidal endothelial cells will further our understanding of AMD pathology. (arvojournals.org)
  • Elastin-like peptides (ELPs) are well suited for solution-based biomedical applications, including drug delivery and biomolecular purification. (aps.org)
  • Microplates were coated with human lung elastin peptides (Elastin Products Company, Owensville, MO, USA) or with PBS (control wells) overnight, then washed and blocked. (ersjournals.com)
  • We have found that the cell penetrating peptides (CPP) Tat or penetratin (Pen), fused with elastin-like polypeptide (CPP-ELP) inhibited adhesion, spreading, invasion and migration of SKOV-3 ovarian cancer cells, SK-MEL-2 melanoma cells, and MDA-MB-231 breast cancer cells in cell culture. (aacrjournals.org)
  • In the body, elastin is usually associated with other proteins in connective tissues. (wikipedia.org)
  • Why We (Love) Collagen & Elastin: Collagen and elastin proteins are naturally present in healthy skin. (wegmans.com)
  • Collagen and elastin are naturally occurring structural proteins normally produced in the dermis , the middle layer of the skin. (wisegeek.com)
  • An important focus will also be novel approaches and analytical tools for investigating elastin and associated proteins in health and disease, and translational approaches for tissue engineering and regenerative medicine. (grc.org)
  • After a genome-wide search for quantitative trait loci (QTL) influencing the aortic elastin, collagen, and cell protein contents in an F2 population derived from BN and LOU rats, we identified on chromosomes 2 and 14, 3 QTL specifically controlling elastin levels, and a further highly significant QTL on chromosome 17 linked to the level of cell proteins. (ahajournals.org)
  • Elastin and collagens are the main extracellular matrix proteins of blood vessels. (ahajournals.org)
  • Assembly of polymeric elastin into its final architecture in the extracellular matrix involves both self-aggregation properties of its monomeric precursor, tropoelastin, and interactions with several matrix-associated proteins that appear to act by modulating the intrinsic self-assembly of tropoelastin. (sigmaaldrich.com)
  • Over the past decade a number of reports have described the design of synthetic genes, which encode elastin-like proteins (ELP) for bacterial expression in Escherichia coli . (pubmedcentralcanada.ca)
  • For example, recombinant silk-elastin proteins have been successfully expressed in tobacco and potato plants 12 . (pubmedcentralcanada.ca)
  • Additionally, the expression of a variety of target proteins in transgenic tobacco has been enhanced by an order of magnitude when fused to elastin-like polypeptides 13 - 15 . (pubmedcentralcanada.ca)
  • Elastins and collagens are proteins that are too large to penetrate the surface of the skin. (udym.com)
  • With 100% naturally sourced moisturizers blended with collagen & elastin proteins, this non-greasy lotion absorbs quickly to help restore and rejuvenate skin. (stives.com)
  • Elastin is made by linking together many small soluble precursor tropoelastin protein molecules (50-70 kDa ), to make the final massive insoluble, durable complex. (wikipedia.org)
  • The unlinked tropoelastin molecules are not normally available in the cell, since they become crosslinked into elastin fibres immediately after their synthesis by the cell and during their export into the extracellular matrix . (wikipedia.org)
  • To make mature elastin fibres, the tropoelastin molecules are cross-linked via their lysine residues with desmosine and isodesmosine cross-linking molecules. (wikipedia.org)
  • The feasibility of using recombinant human tropoelastin to enable elastin fiber production to improve skin flexibility in wounds and scarring has been studied. (wikipedia.org)
  • Tropoelastin is a protein, of size 72kDa, that comes together via cross-links to form elastin in the extracellular matrix of the cell. (wikipedia.org)
  • One of the major reasons that elastin can withstand high levels of stress in the body without experiencing any physical deformation is that the underlying tropoelastin contains domains that are highly hydrophobic. (wikipedia.org)
  • Tropoelastin is the soluble precursor form of elastin. (pnas.org)
  • We previously demonstrated that the inbred Brown Norway (BN) rat shows an aortic elastin deficit in both abdominal and thoracic segments, partly because of a decrease in tropoelastin synthesis when compared with the LOU rat, that elastin gene polymorphisms in these strains do not significantly account for. (ahajournals.org)
  • 7 The aortic elastin deficit in the BN rat is, at least in part, caused by decreased tropoelastin synthesis during the period of rapid growth. (ahajournals.org)
  • Elastin binding protein and FKBP65 modulate in vitro self-assembly of human tropoelastin. (sigmaaldrich.com)
  • Elastin is made by linking many soluble tropoelastin protein molecules, in a reaction catalyzed by lysyl oxidase, to make a massive insoluble, durable cross-linked array. (acris-antibodies.com)
  • Here we describe the production and properties of massive synthetic elastin assemblies formed by chemically cross-linking recombinant human tropoelastin with bis(sulfosuccinimidyl) suberate, permitting the construction of elastic sponges, sheets and tubes. (nih.gov)
  • Elastin is a highly elastic protein in connective tissue and allows many tissues in the body to resume their shape after stretching or contracting. (wikipedia.org)
  • elastin A fibrous protein that is the major constituent of the yellow elastic fibres of connective tissue . (encyclopedia.com)
  • Elastin is a rubberlike protein with fibres that can stretch to many times their normal length. (everything2.com)
  • Elastin is a key protein of the extracellular matrix. (wikipedia.org)
  • Elastin is a very long-lived protein, with a half-life of over 78 years in humans. (wikipedia.org)
  • Elastin-like polypeptides (ELPs) are synthetic biopolymers with potential applications in the fields of cancer therapy, tissue scaffolding, and protein purification. (wikipedia.org)
  • Elastin is the extracellular protein responsible for elasticity in vertebrates. (hindawi.com)
  • Elastin is a versatile elastic protein that dominates flexible tissues capable of recoil, and facilitates commensurate cell interactions in these tissues in all higher vertebrates. (rsc.org)
  • Full length native protein (insoluble alpha elastin purified from human aorta by hot sodium hydroxide). (abcam.com)
  • This protein component is also released from the surface of cultured chondroblasts by incubation with lactose, and its association with immobilized elastin is inhibited by lactose. (sciencemag.org)
  • Elastin is the second most abundant protein in the body. (lorealparisusa.com)
  • The subject of the invention is an elastin-based product consisting of an adduct containing elastin and at least one protein which can be coagulated and/or activated by thrombin. (google.co.uk)
  • This fusion protein retains the performance characteristics of KGF and elastin as evidenced by its enhancement of keratinocyte and fibroblast proliferation. (pnas.org)
  • As a remarkably long-lived protein, elastin can suffer from cumulative effects of exposure to biochemical damages, which can greatly compromise its biomechanical properties. (sigmaaldrich.com)
  • Elastin is a heichly elastic protein in connective tishie an allous mony tishies in the bouk tae resume thair shape efter stretchin or contractin. (wikipedia.org)
  • Elastin is a polymeric protein and is the main component of the extracellular matrix of arteries. (fishersci.com)
  • In this study, we have performed a genetic analysis in an F2 cohort of 161 rats derived from BN and LOU rat strains to detect genetic loci contributing to quantitative variations of aortic elastin, collagen, and cell protein contents and to test a possible relationship between these loci and those linked to susceptibility to aortic IEL ruptures. (ahajournals.org)
  • Fractionation of BAL fluid from wild-type mice found that elastin fragments were the only matrix protein fragments present in the chemotactic fraction of the fluid. (bmj.com)
  • Elastin is a protein that provides the unusual properties of extensibility and elastic recoil to tissues. (sigmaaldrich.com)
  • Both the elastin binding protein (EBP) and FKBP65 have been suggested to fulfill that role in the Golgi and endoplasmic reticulum compartments of the cell, respectively. (sigmaaldrich.com)
  • Elastin is an important polymeric protein of connective tissue that imparts elasticity to vertebrate elastic tissues. (acris-antibodies.com)
  • Elastin is the body's naturally occurring elastic protein and Prof. Weiss and his research group have depended on confocal and scanning electron microscopy in the AMMRF at the University of Sydney to develop and improve their elastin products. (ammrf.org.au)
  • Western blot and immuno-staining confirmed expression of elastin protein. (ahajournals.org)
  • Seven days after coronary artery ligation, BMSCs transfected with genes for either adeno-elastin (BMSC+Elastin) or adeno-green fluorescence protein (BMSC), or media (control group) were injected into the infarct area of adult rats (n=8/group). (ahajournals.org)
  • In this report, we describe a modified concatemerization strategy to construct a gene with enhanced sequence diversity that encodes a highly repetitive elastin-like protein polymer for expression in Pichia pastoris . (pubmedcentralcanada.ca)
  • A fusion protein consisting of a self-cleaving intein and a precipitation tag known as Elastin-Like Peptide (ELP) is one possible purification scheme for increasing the yield of active antimicrobial peptide. (osu.edu)
  • Collagen, elastin, and hyaluronic acid are the essential building blocks of skin. (neocutis.com)
  • The lines on this chart represent when and how quickly collagen, elastin, and hyaluronic acid typically break down. (neocutis.com)
  • Depletion of collagen and hyaluronic acid happens before elastin loss. (neocutis.com)
  • Elastin, Hyaluronic Acid, Squalane and Aloe provide the perfect combination for delivering results. (pevonia.co.uk)
  • Elastin networks in the extracellular matrix are essential for the functioning of such organs as lungs , skin and blood vessels which require strong but elastic tissue . (everything2.com)
  • Elastin-rich lung extracellular matrix is largely remodeled during tumor invasion. (semanticscholar.org)
  • Extracellular matrix molecules such as elastin and collagens provide mechanical support to the vessel wall. (ahajournals.org)
  • The composition of the arterial extracellular matrix and the adaptative synthesis of elastin and collagen in hypertension may also influence the degree of reversibility of arterial remodeling in response to antihypertensive treatment and the development of hypertensive arteriopathy. (ahajournals.org)
  • MMP-12 degrades lung extracellular matrix components and generates the production of elastin fragments that are chemotactic to monocytes and which drive disease progression. (bmj.com)
  • Over-expression of elastin in transplanted BMSCs contributed to the alignment and organization of an elastic extracellular matrix structure, which prevented cardiac dilatation and dysfunction. (ahajournals.org)
  • Elastin plays a key role in the remodeling of the extracellular matrix. (ahajournals.org)
  • It is thought that elastin has a random coil formation in its "relaxed" state which can be stretched out while cross-links between chains hold the molecules together and collagen fibrils are interwoven with the fibres to limit stretching and prevent tearing. (everything2.com)
  • In addition elastin fibres are covered with a sheath of microfibrils composed of glycoproteins such as fibrillin which are required for assembly and to maintain the integrity of the fibre. (everything2.com)
  • The Elastin Sports Tape is constructed from a combination of a special cotton fibres and mucus coating which allows adhesive. (fuzing.com)
  • Methods The authors measured cutaneous elastin degradation using immunohistochemistry (percentage area of elastin fibres) in sun-exposed (exposed) and non-sun-exposed (non-exposed) skin biopsies in 16 men with COPD and 15 controls matched for age and cigarette smoke exposure. (bmj.com)
  • and 3) typical elastic fibres consisting of microfibrils and abundant elastin. (lymphedemapeople.com)
  • There are, however, only scant data on the role of elastin and its receptors in tumor invasion. (nih.gov)
  • So it was that the role of elastin in skin and aging came to mind again. (fightaging.org)
  • The attached abstract explains the role of elastin in lymph capillaries, A fibrillar elastic apparatus around human lymph capillaries. (lymphedemapeople.com)
  • Zinc, typically found in meats, dairy products, and seafood, is believed crucial for the maintenance of elastin fibers. (wisegeek.com)
  • Frances, C. and Robert, L. Elastin and elastic fibers in normal and pathologic skin. (lorealparisusa.com)
  • The Gordon Research Seminar on Elastin, Elastic Fibers and Microfibrils is a dynamic research forum for graduate students, post-docs and early career scientists at the forefront of elastic fiber-related research to present their own cutting-edge findings and exchange ideas amongst their peers, as well as established faculty in the field. (grc.org)
  • This meeting encourages young scientists from a broad range of backgrounds and interests to lead discussions on topics including the structure and assembly of elastin, elastic fibers and microfibrils, elastic tissue mechanics and mechanisms of development and aging, as well as matrix regulation of cell signaling. (grc.org)
  • This GRS will be held in conjunction with the "Elastin, Elastic Fibers and Microfibrils" Gordon Research Conference (GRC). (grc.org)
  • Collagen and elastin are fibers that make up the supporting structure of the skin. (sharecare.com)
  • The only way to boost collagen and elastin in the skin is to turn on the fibroblast cells that produce these fibers. (sharecare.com)
  • Elastin is a major constituent of skin elastic fibers and may be beneficial for dermal regeneration ( 16 ). (pnas.org)
  • During aging, the elasticity of connective tissue is reduced because of the cross-linking of collagenous fibers with elastin. (fishersci.com)
  • Elastic fibers composed of an elastin core surrounded by microfibrils are designed to maintain elastic function in tissues such as blood vessels, lungs, and skin. (ahajournals.org)
  • The quiz and worksheet help you check your understanding of comparing collagen and elastin fibers. (study.com)
  • You can review more topics by going through the lesson called Collagen vs. Elastin Fibers. (study.com)
  • Their activities must be counteracted with antioxidants or they will harm the cellular membrane along with the collagen, elastin fibers and cell DNA. (udym.com)
  • Elastin - the elastic fibers found between the collagen fibers, responsible for the firmness of the skin. (catcosmetics.com)
  • [4] Other associated defects in elastin include Marfan syndrome , emphysema caused by α 1 -antitrypsin deficiency, atherosclerosis , Buschke-Ollendorff syndrome , Menkes syndrome , pseudoxanthoma elasticum , and Williams syndrome . (wikipedia.org)
  • The enzymes responsible for degradation of pulmonary elastin have not been established but three possibilities will be discussed: Polymorphonuclear leukocyte elastase which in phenotypical ly normal (α 1 -antitrypsin) MM subjects has been found to be present in statistically significantly higher amounts in patients with emphysema as compared with normal human subjects (2) alveolar macrophage elastase (3) specific tissue elastases. (springer.com)
  • Mandl I., Darnule T.V., Fierer J.A., Keller S., Turino G.M. (1977) Elastin Degradation in Human and Experimental Emphysema. (springer.com)
  • Background Development of emphysema and vascular stiffness in chronic obstructive pulmonary disease (COPD) may be due to a common mechanism of susceptibility to pulmonary and systemic elastin degradation. (bmj.com)
  • In the entire cohort of ex-smokers, cutaneous elastin degradation was associated with emphysema severity, FEV 1 and pulse wave velocity. (bmj.com)
  • Conclusions Patients with COPD have increased skin elastin degradation compared with controls, which is related to emphysema severity and arterial stiffness. (bmj.com)
  • Men with chronic obstructive pulmonary disease (COPD) have increased skin elastin degradation compared with controls matched for age and smoking history, and this was associated with arterial stiffness and emphysema severity. (bmj.com)
  • Elastin fragments drive disease progression in a murine model of emphysema. (bmj.com)
  • Immunological processes and especially autoreactive immune processes have recently been implicated, with anti-elastin antibodies and a T-helper type-1 lymphocyte response identified in patients with COPD/emphysema 1 . (ersjournals.com)
  • We explored whether an autoimmune process implicating anti-elastin autoantibodies and facilitated by tobacco smoking may take place in patients with combined pulmonary fibrosis and emphysema (CPFE), a distinct entity recently defined on the basis of characteristic features of chest imaging, pulmonary function and outcome 4 . (ersjournals.com)
  • Quantification of anti-elastin antibodies using ELISA in patients with combined pulmonary fibrosis and emphysema (CPFE) and controls. (ersjournals.com)
  • Our results do not support the idea that either emphysema or fibrosis in CPFE may be mediated by an autoimmune process directed against elastin. (ersjournals.com)
  • Since all patients with CPFE had emphysema on imaging (mostly paraseptal emphysema, and also centrolobular emphysema), our results also fail to confirm the presence of circulating anti-elastin antibodies in patients with emphysema (at least when associated with fibrosis). (ersjournals.com)
  • Intoxication of rats with mercuric chloride (0.5 mg Hg/kg of body weight, daily for 10 weeks) increased the hepatic contents of soluble and insoluble collagen and elastin. (srce.hr)
  • These new techniques, as well as some previously published by other workers, were evaluated with the help of antiserum raised in sheep against insoluble chick elastin. (biochemj.org)
  • Biochemical analysis detected over-expression of recombinant elastin, and histological examination revealed that collagen fiber length and diameter were preserved in the scar tissue. (ahajournals.org)
  • Elastin's primary structure consists of alternating hydrophobic segments (supposedly responsible for the protein's elasticity) and alanine and lysine-rich alpha helical segments responsible for cross-linking with adjacent elastin molecules. (everything2.com)
  • While there are lots of collagen and elastin creams available these molecules are far too large to penetrate the skin. (sharecare.com)
  • The functionalization process has led to an effective attachment of collagen and elastin-like recombinamer (ELR) molecules. (upc.edu)
  • Collagen and elastin molecules are too large to penetrate through your skin surface. (bestofmissourihands.com)
  • We already know all about Elastatropin in our B and E versions: that it helps to reduce the onset and appearance of wrinkles, small amounts applied daily in early adulthood can maintain a youthful level of elastin while older consumers through continued regular application can eventually replenish elastin and protect against new wrinkles. (bio-medicine.org)
  • Now continuous use of Bx Pro/Face for one year with higher doses of Elastatropin will diminish wrinkles even further as it provides six times the amount of elastin lost in that year. (bio-medicine.org)
  • Simultaneously, Elastin-rp stimulates the skin's natural healing ability and facilitates faster skin turnover to give you more supple and more elastic skin that is firmer and less prone to developing wrinkles and other signs of aging. (consumerhealthdigest.com)
  • Elastin-rp is made with a unique combination of active ingredients through the BioLastin Complex that supports improved skin elasticity which, in turn, makes fine lines and wrinkles much less visible. (consumerhealthdigest.com)
  • In: Sandberg L.B., Gray W.R., Franzblau C. (eds) Elastin and Elastic Tissue. (springer.com)
  • Elastin serves an important function in arteries as a medium for pressure wave propagation to help blood flow and is particularly abundant in large elastic blood vessels such as the aorta . (wikipedia.org)
  • Genetically determined minor modifications in elastin and collagen in the aorta could influence the onset and evolution of arterial pathology, such as hypertension and its complications. (ahajournals.org)
  • The inbred Brown Norway (BN) rat strain shows an aortic elastin deficit (by 5.8% dry weight when compared with the inbred LOU rat) 5,6 and is also highly susceptible to spontaneous rupture of the internal elastic lamina (IEL) in its abdominal aorta. (ahajournals.org)
  • Elastin is particularly abundant in large elastic blood vessels such as the aorta. (acris-antibodies.com)
  • Our Collagen Elastin is a powerful smart-aging serum to ward off the signs of aging to maintain healthy + youthful skin! (pureandsimple.ca)
  • With 5% marine collagen + elastin, this high performing, lightweight serum rebuilds your skin's collagen + supports natural collagen production, making it a highly effective anti-aging product. (pureandsimple.ca)
  • and that being said, is there a C serum out there that contains ingredients that support elastin production? (smartskincare.com)
  • Feine Linien und Fältchen können Sie mit dem Declaré Collagen & Elastin Booster Serum lindern. (parfumdreams.de)
  • EWG scientists reviewed St. Ives Body Lotion, Skin Renewing Collagen Elastin (2014 formulation) for safety according to the methodology outlined in our Skin Deep Cosmetics Database. (ewg.org)
  • Volume I explains elastin, its biosynthesis, physicochemical properties, and alteration in a variety of pathologies and with aging. (routledge.com)
  • Elastin Monoclonal antibody specifically detects Elastin in Human samples. (fishersci.com)
  • The use of an elastin fragment antibody resulted in monocyte chemotaxis inhibition, even in the presence of cigarette smoke. (bmj.com)
  • Elastin fragment inhibition by elastin fragment antibody reduced lung macrophage accumulation and airspace disease in this model. (bmj.com)
  • Objectives To investigate whether patients with COPD have evidence of systemic elastin degradation in the skin. (bmj.com)
  • Systemic elastin degradation due to increased proteolytic activity may represent a novel shared mechanism for the pulmonary, vascular and cutaneous features of COPD. (bmj.com)
  • Is systemic elastin degradation the mechanism of increased arterial stiffness and skin wrinkling in chronic obstructive pulmonary disease? (bmj.com)
  • Systemic elastin degradation due to increased proteolytic activity may represent a novel shared mechanism for the pulmonary, vascular and cutaneous features of chronic obstructive pulmonary disease. (bmj.com)
  • Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis. (semanticscholar.org)
  • In skincare, elastin products are most commonly found in the form of moisturizers (i.e. elastin cream). (lorealparisusa.com)
  • Elastin Collagen Cream BACK IN STOCK! (catcosmetics.com)
  • This is the exact same Elastin Collagen Cream, only the packaging and the name has had a face lift! (catcosmetics.com)
  • Anti-aging day cream with Collagen, Elastin and Jojoba. (catcosmetics.com)
  • Elastin Collagen Cream! (catcosmetics.com)
  • Collagen and elastin found in cream products cannot fuse properly with the collagen and elastin found in your skin. (bestofmissourihands.com)
  • Compared to the B and E versions of DermaLastyl currently available, the Bx Pro/Face formula contains higher doses of Elastatropin equal to six times the amount of elastin being lost in one year. (bio-medicine.org)
  • Here is a study that says vitamin c and derivatives DO promote synthesis of elastin, in fact it says that MAP strongly promotes synthesis of elastin. (smartskincare.com)
  • In previous studies 'anchoring filaments' of human lymphatic capillaries have been shown to consist of microfibrils having histochemical and ultrastructural characteristics similar to elastin-associated microfibrils. (lymphedemapeople.com)
  • When not associated with an elastin component, these microfibrils are referred to as 'oxytalan microfibrils. (lymphedemapeople.com)
  • Elastic fiber in the body is a mixture of amorphous elastin and fibrous fibrillin . (wikipedia.org)
  • Elastin is considered an essential building block of the fibrous tissue that keeps skin flexible and elastic. (wisegeek.com)
  • Elastin is one of the most recommended proteinic ingredients to revitalize and tighten the skin while improving elasticity and suppleness. (pevonia.co.uk)
  • Elastin-rp Ingredients - Are they Safe & Effective? (consumerhealthdigest.com)
  • The use of nutrients and naturally occurring ingredients that stimulate the growth of collagens is prevalent in the current collagen elastin therapy. (udym.com)
  • We evaluated the consequences of EDP accumulation in mice and of elastin receptor complex (ERC) activation on lipid storage in hepatocytes, inflammation, and fibrosis development. (diabetesjournals.org)
  • We tested this hypothesis by determining smooth muscle extension and elastin accumulation along pulmonary arteries (PAs) and veins (PVs) in 3 groups of lambs. (nature.com)
  • Muscularization of PAs and elastin accumulation in PAs and PVs may contribute to the histologic and extravascular lung water content evidence of pulmonary edema, and the sustained PVR by increasing the filtration pressure and resistance along the pulmonary microcirculation. (nature.com)
  • Some people believe that it could prevent the accumulation of elastin that is seen in photoaged skin. (smartskincare.com)
  • Various foods are considered capable of helping the skin to maintain youthful collagen and elastin levels. (wisegeek.com)
  • Elastin: Healthy levels of Elastin help preserve the elasticity and firmness of youthful skin. (vitasprings.com)
  • The elastin receptor complex contains a component of 67 kilodaltons that binds to a glycoconjugate affinity column containing beta-galactoside residues and is eluted from this column with lactose. (sciencemag.org)
  • Since lactose also blocks elastic fiber formation by cultured chondroblasts, the galactoside-binding property of the elastin receptor is implicated in this process. (sciencemag.org)
  • Putative role of 67 kDa elastin-laminin receptor in tumor invasion. (nih.gov)
  • Nevertheless, experimental evidence indicates that the 67 kDa elastin-laminin receptor (ELR) subunit plays an important role in tumor invasion by mediating essential tumor cell functions leading to metastases. (nih.gov)
  • Our current investigation aims to determine the effects of elevated elastin fragments in vivo and to identify the possible endothelial cell receptor(s) responsible for this activity. (arvojournals.org)
  • Collagen and elastin are the structure of the skin that maintains both elasticity and firmness. (sharecare.com)
  • Collagen gives skin its firmness while elastin keeps skin tight. (sharecare.com)
  • Suitable for all skin types, the Elastin Wet Collagen Eye Mask is blended with vitamins, acids, and extracts to restore the skin's natural moisture and give firmness to the delicate muscles around the eye area. (universalcompanies.com)
  • The purpose of this study is to investigate the effects of glucose on mechanical properties of isolated porcine aortic elastin. (sigmaaldrich.com)
  • 5 Because the elastin gene polymorphism explains only a small part of differences between parental strains, it is thus probable that other genes account for the major proportion of the interstrain differences in aortic elastin content. (ahajournals.org)
  • Best results when used after the Firming Marine Elastin Concentrate. (pevonia.co.uk)
  • Biochemistry of Collagens, Laminins and Elastin Edition by Morten Karsdal and Publisher Academic Press. (vitalsource.com)
  • There are many effective collagen skin remedies that do not even contain use of any collagens and elastins. (udym.com)
  • Many 'bio-available' collagen elastin skin remedies can give relief from itching, reduce redness, heal dermatitis and inflammation of skin along with increasing the cells and collagens that are present in the body. (udym.com)
  • In this work, we present a novel method for visualization of local temperature increase using elastin-like polypeptides (ELP). (rsc.org)
  • [9] Comparison between fresh and digested tissues shows that, at 35% strain, a minimum of 48% of the arterial load is carried by elastin, and a minimum of 43% of the change in stiffness of arterial tissue is due to the change in elastin stiffness. (wikipedia.org)
  • Effect of glucose on the biomechanical function of arterial elastin. (sigmaaldrich.com)
  • Elastin performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. (fishersci.com)
  • The elastin-null mice (ELN −/− ) die of obstructive arterial disease, 2 whereas the ELN +/− mice have reduced absolute quantities of elastin and are hypertensive, phenotypes similar to those observed in patients with supravalvular aortic stenosis and Williams syndrome. (ahajournals.org)
  • Investigating the genetic basis and pathophysiological consequences of the modulation of elastin levels, rather than the impact of absolute elastin deficit, is central to our understanding of mechanisms involved in arterial pathologies. (ahajournals.org)
  • Elastin is essential to provide elastic support for blood vessels. (sigmaaldrich.com)
  • Topical skin-care creams containing collagen and elastin are widely available from many manufacturers. (wisegeek.com)
  • Ideal for face & throat - it's infused with Vitamins A & E. Its elastin and collagen help prepare skin for application of active creams or serums used afterwards. (puritan.com)
  • Laser hair removal, collagen and elastin creams come up every time you ask any hip, urbane woman what they do to stay beautiful. (bestofmissourihands.com)
  • Anti-elastin antibodies were quantified using modified ELISA as previously described 1 . (ersjournals.com)
  • Dermatologists believe that these products, while often very moisturizing, don't actually increase collagen or elastin levels in the skin. (wisegeek.com)
  • I understand that there are many people who swear by C serums but if you look at this published study it is clear that C does increase collagen but elastin is decreased. (smartskincare.com)
  • Elevated elastin fragments promote choroidal endothelial cells to increase migration, a key event in neovascular age-related macular degeneration (AMD). (arvojournals.org)
  • Albino C57/BL 6 mice were injected intraperitoneally with elastin fragments or control saline 3x weekly for one month. (arvojournals.org)
  • No major ultrastructural differences were detected in eyes of mice injected with elastin fragments compared to control eyes. (arvojournals.org)
  • In vivo, elastin fragments cause a significant increase in the transcription of genes which may play a role in pathways associated with AMD. (arvojournals.org)
  • 1 , exposure to tobacco smoking might increase secretion of proteolytic enzymes in the lung from cells of the innate immune system, thereby liberating lung elastin fragments and initiating elastin-targeted T- and B-cell mediated immunity in susceptible individuals. (ersjournals.com)
  • You can earn a 5% commission by selling GIGI COLLAGEN ELASTIN CONCENTRATE 50ml on your website. (fishpond.co.nz)
  • For fluorescence of elastin hydrolysates we observed both, a decrease and increase of this value during irradiation of the sample. (biomedsearch.com)
  • The fluorescence of elastin hydrolysates was observed at 305 nm and at 380 nm after excitation at 270 nm. (biomedsearch.com)
  • Intrinsic fluorescence spectroscopy demonstrated that the elastin fluorophore is a feature of the polypeptide. (nih.gov)
  • Elastosis is the buildup of elastin in tissues, and is a form of degenerative disease. (wikipedia.org)
  • Hinek, A.: Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren syndrome. (acris-antibodies.com)
  • 2. An elastin containing composition consisting essentially of a synthetic compound resulting from the reaction of fibrin monomers with elastin. (google.co.uk)
  • The innate characteristics of synthetic elastin constructs are common with those of native elastin. (nih.gov)
  • We conclude that synthetic elastin has potential as a novel biomaterial that can be easily molded into a variety of shaped tissue substrates and has a range of properties that are required for elastic, cell-interacting and compliant applications. (nih.gov)
  • Prof. Tony Weiss from the University of Sydney in conjunction with Elastagen Pty Ltd has been awarded a $1million Translation Award from the Wellcome Trust to fast track their elastin-based synthetic skin to clinical trials. (ammrf.org.au)
  • Elastin is particularly abundant in elastic cartilage , blood-vessel walls, ligaments, and the heart. (encyclopedia.com)
  • Full-length elastin cDNA was generated by PCR using the human lung cDNA library, and then transfected (in adenoviral vector) into rat bone marrow stromal cells (BMSCs). (ahajournals.org)
  • 1. An elastin containing composition comprising fibronectin and wherein elastin is covalently bound to fibrin monomers. (google.co.uk)
  • 6. An elastin containing composition according to claim 1, further comprising at least one additive selected from the group consisting of collagen, thiourea, cellulose derivatives, calcium alginate, sodium ethylmercrylthiosalicylate, FVIII complex (antihemophilic A), the latter containing about 10 to 15 g/l of fibrinogen and about 2 to 4 g/l of fibronectin, von Willebrand factor, thrombospondin and laminin. (google.co.uk)
  • 7. An elastin containing composition according to claim 2, wherein the elastin and fibrin monomers are of human origin. (google.co.uk)
  • 10. An elastin containing composition according to claim 6, wherein said elastin containing composition is an adduct in the form of a cross-linked network. (google.co.uk)