Elastin. Medical search

A salt-soluble precursor of elastin. Lysyl oxidase is instrumental in converting it to elastin in connective tissue.

A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.

Connective tissue comprised chiefly of elastic fibers. Elastic fibers have two components: ELASTIN and MICROFIBRILS.

2-(4-Amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinium. A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.

A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.

An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield peptidyl-allysyl-peptide plus ammonia & hydrogen peroxide. EC 1.4.3.13.

Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).

A pathological constriction occurring in the region above the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.

A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)

The main trunk of the systemic arteries.

A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a role in INFLAMMATION and WOUND HEALING.

A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.

Resistance and recovery from distortion of shape.

Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.

A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.

Components of the extracellular matrix consisting primarily of fibrillin. They are essential for the integrity of elastic fibers.

Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.

Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.

The study of the physical and chemical properties of a drug and its dosage form as related to the onset, duration, and intensity of its action.

Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.

An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.

Organizations established by endowments with provision for future maintenance.

The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.

Gross hypo- or aplasia of one or more long bones of one or more limbs. The concept includes amelia, hemimelia, phocomelia, and sirenomelia.

Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.

Exclusive legal rights or privileges applied to inventions, plants, etc.

The combining of administrative and organizational resources of two or more health care facilities.

Services offered to the library user. They include reference and circulation.

The scientific study of past societies through artifacts, fossils, etc.

A class of animal lectins that bind specifically to beta-galactoside in a calcium-independent manner. Members of this class are distiguished from other lectins by the presence of a conserved carbohydrate recognition domain. The majority of proteins in this class bind to sugar molecules in a sulfhydryl-dependent manner and are often referred to as S-type lectins, however this property is not required for membership in this class.

Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of galactose with an alcohol to form an acetal. They include both alpha- and beta-galactosides.

A galectin found abundantly in smooth muscle (MUSCLE, SMOOTH) and SKELETAL MUSCLE and many other tissues. It occurs as a homodimer with two 14-kDa subunits.

Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.

A flat, flexible strip of material used to cover or fasten together damaged tissue.

Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.

The field of medicine concerned with physical fitness and the diagnosis and treatment of injuries sustained in exercise and sports activities.

Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.

Adhesive tape with the mechanical strength to resist stretching. It is applied to the skin to support, stabilize, and restrict movement to aid healing and/or prevent injuries of MUSCULOSKELETAL SYSTEM.

Substances and materials manufactured for use in various technologies and industries and for domestic use.

Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)

Formal voluntary or governmental procedures and standards required of hospitals and health or other facilities to improve operating efficiency, and for the protection of the consumer.

An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.

An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)

That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.

Repopulation of different layers of host human Bruch's membrane by retinal pigment epithelial cell grafts. (1/1299)

PURPOSE: To determine the morphology of human retinal pigment epithelium (RPE) after reattachment to different ultrastructural layers of human Bruch's membrane (BM). METHODS: Bruch's membrane explants were prepared from eyes of 23 human donors (age range, 11-89 years). The basal lamina of the RPE, inner collagenous layer, and elastin layer were removed sequentially by mechanical and enzymatic techniques. First-passage cells of human RPE (15,000 cells/6 mm explant) from three donors (ages, 52, 64, and 80 years) were plated onto different layers of human BM, and the explants were examined by scanning and transmission electron microscopy up to 21 days later. RESULTS: RPE flattened and extended footplates 6 hours after plating onto basal lamina. Cells remained round 6 and 24 hours after plating onto the inner collagenous, elastin, or outer collagenous layer. The RPE cells became confluent 14 days after plating onto basal lamina but did not become confluent up to 21 days after plating onto the inner collagenous or elastin layer. Sparse round cells were observed 21 days after plating onto deeper layers, suggesting extensive loss of RPE. CONCLUSIONS: The morphology and subsequent behavior of the RPE reattached to BM depends on the anatomic layer of BM available for cell reattachment. The results suggest that the ability of transplanted RPE to repopulate BM in age-related macular degeneration and other disorders may depend on the layer of BM available to serve as a substrate for cell reattachment. (+info)

Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). (2/1299)

BACKGROUND: Abdominal aortic aneurysms (AAAs) are associated with chronic inflammation, disruption of medial elastin, and increased local production of elastolytic matrix metalloproteinases (MMPs). The purpose of this study was to investigate how treatment with a hydroxamate-based MMP antagonist (RS 132908) might affect the development of experimental AAAs. METHODS: Male Wistar rats underwent intraluminal perfusion of the abdominal aorta with 50 units of porcine pancreatic elastase followed by treatment for 14 days with RS 132908 (100 mg/kg/day subcutaneously; n = 8) or with vehicle alone (n = 6). The external aortic diameter (AD) was measured in millimeters before elastase perfusion and at death, with AAA defined as an increase in AD (DeltaAD) of at least 100%. Aortic wall elastin and collagen concentrations were measured with assays for desmosine and hydroxyproline, and fixed aortic tissues were examined by light microscopy. RESULTS: AAAs developed in all vehicle-treated rats, with a mean AD (+/- SE) that increased from 1.60 +/- 0.03 mm before perfusion to 5.98 +/- 1.02 mm on day 14 (DeltaAD = 276.4 +/- 67.7%). AAAs developed in only five of eight animals (62.5%) after MMP inhibition, with a mean AD that increased from 1.56 +/- 0.05 mm to 3.59 +/- 0.34 mm (DeltaAD = 128.1 +/- 18.7%; P <.05, vs vehicle). The overall inhibition of aortic dilatation attributable to RS 132908 was 53.6 +/- 6.8%. Aortic wall desmosine fell by 85.4% in the vehicle-treated rats (1210.6 +/- 87.8 pmol/sample to 176.7 +/- 33.4 pmol/sample; P <.05) but only by 65.6% in the animals treated with RS 312908 (416.2 +/- 120.5 pmol/sample). In contrast, hydroxyproline was not significantly affected by either elastase perfusion or drug treatment. Microscopic examination revealed the preservation of pericellular elastin and a greater degree of fibrocollagenous wall thickening after MMP inhibition, with no detectable difference in the extent of inflammation. CONCLUSIONS: Systemic MMP inhibition suppresses aneurysmal dilatation in the elastase-induced rodent model of AAA. Consistent with its direct inhibitory effect on various MMPs, RS 132908 promotes the preservation of aortic elastin and appears to enhance a profibrotic response within the aortic wall. Hydroxamate-based MMP antagonists may therefore be useful in the development of pharmacologic approaches to the suppression of AAAs. (+info)

Connective tissues: matrix composition and its relevance to physical therapy. (3/1299)

In the last 2 decades, the understanding of CT structure and function has increased enormously. It is now clear that the cells of the various CTs synthesize a variety of ECM components that act not only to underpin the specific biomechanical and functional properties of tissues, but also to regulate a variety of cellular functions. Importantly for the physical therapist, and as discussed above, CTs are responsive to changes in the mechanical environment, both naturally occurring and applied. The relative proportions of collagens and PGs largely determine the mechanical properties of CTs. The relationship between the fibril-forming collagens and PG concentration is reciprocal. Connective tissues designed to resist high tensile forces are high in collagen and low in total PG content (mostly dermatan sulphate PGs), whereas CTs subjected to compressive forces have a greater PG content (mostly chondroitin sulphate PGs). Hyaluronan has multiple roles and not only provides tissue hydration and facilitation of gliding and sliding movements but also forms an integral component of large PG aggregates in pressure-resisting tissues. The smaller glycoproteins help to stabilize and link collagens and PGs to the cell surface. The result is a complex interacting network of matrix molecules, which determines both the mechanical properties and the metabolic responses of tissues. Patients with CT problems affecting movement are frequently examined and treated by physical therapists. A knowledge of the CT matrix composition and its relationship to the biomechanical properties of these tissues, particularly the predictable responses to changing mechanical forces, offers an opportunity to provide a rational basis for treatments. The complexity of the interplay among the components, however, requires that further research be undertaken to determine more precisely the effects of treatments on the structure and function of CTs. (+info)

Interaction between leukocyte elastase and elastin: quantitative and catalytic analyses. (4/1299)

Solubilization of elastin by human leukocyte elastase (HLE) cannot be analyzed by conventional kinetic methods because the biologically relevant substrate is insoluble and the concentration of enzyme-substrate complex has no physical meaning. We now report quantitative measurements of the binding and catalytic interaction between HLE and elastin permitted by analogy to receptor-ligand systems. Our results indicated that a limited and relatively constant number of enzyme binding sites were available on elastin, and that new sites became accessible as catalysis proceeded. The activation energies and solvent deuterium isotope effects were similar for catalysis of elastin and a soluble peptide substrate by HLE, yet the turnover number for HLE digestion of elastin was 200-2000-fold lower than that of HLE acting on soluble peptide substrates. Analysis of the binding of HLE to elastin at 0 degrees C, in the absence of significant catalytic activity, demonstrated two classes of binding sites (Kd=9.3x10(-9) M and 2.5x10(-7) M). The higher affinity sites accounted for only 6% of the total HLE binding capacity, but essentially all of the catalytic activity, and dissociation of HLE from these sites was minimal. Our studies suggest that interaction of HLE with elastin in vivo may be very persistent and permit progressive solubilization of this structurally important extracellular matrix component. (+info)

UVB irradiation stimulates deposition of new elastic fibers by modified epithelial cells surrounding the hair follicles and sebaceous glands in mice. (5/1299)

UVB irradiation stimulates the synthesis of elastin in the skin of humans and experimental animals. In this study we localized the site and the cells that are responsible for the synthesis of murine dermal elastic fibers. SKH-1 hairless mice were irradiated with UVB and the skin removed for light microscopy, electron microscopy, in situ hybridization, immunohistochemistry, and biochemical studies. In response to chronic low doses of UVB there was an initial moderate increase in tropoelastin mRNA in the papillary dermis. By contrast, there was a continuous marked elevation of collagen alpha1(I) message localizing to sites of inflammatory cell influx throughout the upper and lower dermis. After 25 wk of UV irradiation there was a 2-fold increase in skin elastin, yet total collagen remained unchanged. Serial desmosine analysis from en face sections indicated the increase in elastin content was due to dermal elastic fibers, an increase in the size and number of the dermal cysts, and an increase in subpanniculus elastic fibers. Elastin stains of en face sections suggested that the elastic fibers in the upper dermis were exclusively derived from cells lining the epithelial root sheath and sebaceous glands. In response to UV irradiation, the elastic fibers increased in number and size, wrapping around these structures and aligning in both directions as long fibers parallel to the body axis. Electron micrographs indicated that modified epithelial cells in close proximity to the flattened epithelial cells that encircled the root sheath and sebaceous glands were the source of the elastic fibers. (+info)

Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis. (6/1299)

Serine elastases degrade elastin, stimulate vascular smooth muscle cell migration and proliferation, and are associated with myocardial damage. To evaluate the impact of elastase inhibition on cardiovascular development and disease, transgenic mice were created in which the mouse preproendothelin-1 promoter was used to target elafin overexpression to the cardiovascular system. To distinguish the transgene from endogenous elafin, constructs were made incorporating a FLAG sequence; the COOH-terminus FLAG-tagged elafin construct produced a stable, functionally active gene product and was used to create transgenic mice. Consistent with endothelin expression, abundant elafin mRNA was observed in transgenic F1 embryos (embryonic day 13.5) and in adult transgenic mice heart, trachea, aorta, kidney, lung, and skin, but not in liver, spleen, and intestine. Functional activity of the transgene was confirmed by heightened myocardial elastase inhibitory activity. No tissue abnormalities were detected by light microscopy or elastin content. However, injection of 10 plaque-forming units (PFU) of encephalomyocarditis virus resulted in death within 11 days in 10 out of 12 nontransgenic mice compared with one out of nine transgenic littermates. This reduced mortality was associated with better cardiac function and less myocardial inflammatory damage. Thus, elafin expression may confer a protective advantage in myocarditis and other inflammatory diseases. (+info)

The smooth muscle cell. III. Elastin synthesis in arterial smooth muscle cell culture. (7/1299)

Primate arterial smooth muscle cells and skin fibroblasts were examined for their ability to synthesize elastin in culture. In the presence of the lathyrogen beta-aminopropionitrile, the smooth muscle cells incorporate [3H]lysine into a lysyl oxidase substrate that was present in the medium and associated with the cell layer. A component having a mol wt of 72,000 and an electrophoretic mobility similar to that of authentic tropoelastin was isolated from the labeled smooth muscle cells by coacervation and fractionation with organic solvents. In the absence of beta-aminopropionitrile, long-term cultures of smooth muscle cells incorporated [14C]lysine into desmosine and isodesmosine, the cross-link amino acids unique to elastin. In contrast, no desmosine formation occurred in the fibroblast cultures. These characteristics demonstrate that arterial smooth muscle cells are capable of synthesizing both soluble and cross-lined elastin in culture. (+info)

Identification of a large region of secondary structure in the 3'-untranslated region of chicken elastin mRNA with implications for the regulation of mRNA stability. (8/1299)

Synthesis of aortic elastin peaks in the perinatal period and then is strongly down-regulated with postnatal vascular development. Our laboratory has previously shown that changes in elastin mRNA stability contribute to this developmental decrease in elastin production. Here we identify a large region of stable secondary structure in the 3'-untranslated region (3'-UTR) of chicken elastin mRNA. Reverse transcriptase polymerase chain reaction or polymerase chain reaction amplification of the 3'-UTR consistently resulted in products with an approximately 328-bp deletion from the central region of the 3'-UTR, suggesting the presence of secondary structure. The presence of this structure was confirmed by probing the 3'-UTR with RNases with selectivity for single- or double-stranded RNA. Gel migration shift assays using cytosolic extracts from 2-day old chicken aorta demonstrate specific binding of a cytosolic protein to riboprobes containing the 3'-UTR of elastin but not to riboprobes either corresponding to other areas of the message or containing the 3'-UTR but lacking the region of secondary structure. Binding of cytosolic protein was particularly prominent in aortic extracts from 2-day old chickens, a time when elastin message is stable, as compared with 8- and 15-week old chickens, when the elastin message is relatively unstable, suggesting that this region of secondary structure may play a role in developmental regulation of stability of elastin mRNA. (+info)

... and these tissues contain high amounts of elastins. Elastins are synthesized by fibroblasts and smooth muscle cells. Elastins ... Elastin[edit]. Elastins, in contrast to collagens, give elasticity to tissues, allowing them to stretch when needed and then ... Disorders such as cutis laxa and Williams syndrome are associated with deficient or absent elastin fibers in the ECM.[9] ... This property is primarily dependent on collagen and elastin concentration,[2] and it has recently been shown to play an ...

https://en.wikipedia.org/wiki/Extracellular_matrix

... helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing ... "Elastin (ELN)". Retrieved 31 October 2011.. *^ Muiznieks LD, Weiss AS, Keeley FW (Apr 2010). "Structural disorder and dynamics ... Elastin is also very important in the lungs, elastic ligaments, elastic cartilage, the skin, and the bladder. It is present in ... Elastin is a highly elastic protein in connective tissue and allows many tissues in the body to resume their shape after ...

https://en.wikipedia.org/wiki/Tropoelastin

Maintenance of crosslinked elastin is carried out by a number of proteins including lysyl oxidase-like 1 protein. Mature ... Elastic fibers include elastin, elaunin and oxytalan. Elastic tissue is classified as "connective tissue proper". Elastic ... Cutis laxa and Williams syndrome have elastic matrix defects that have been directly associated with alterations in the elastin ... Schräder CU, Heinz A, Majovsky P, Karaman Mayack B, Brinckmann J, Sippl W, Schmelzer CE (September 2018). "Elastin is ...

https://en.wikipedia.org/wiki/Elastic_fiber

Elastin is the key protein of the extracellular matrix and is the main component of the elastic fibres. Elastin gives the ... Elastin is more concentrated in areas of high stress such as the openings of the alveoli, and alveolar junctions. The ... Elastase breaks down the elastin in the lung's connective tissue that can also result in emphysema. Elastase is inhibited by ... Mithieux, Suzanne M.; Weiss, Anthony S. (2005). "Elastin". Fibrous Proteins: Coiled-Coils, Collagen and Elastomers. Advances in ...

https://en.wikipedia.org/wiki/Lung

Ladislas Robert (1989). Elastin and elastases. Boca Raton, Fla.: CRC Pr. ISBN 0-8493-6429-9.CS1 maint: extra text: authors list ...

https://en.wikipedia.org/wiki/Streptomyces_noboritoensis

Elastin fibers stain dark purple/black with Verhoeff's stain. The extracellular matrix contains Elastin, fibrillin, ... Elastic fibers within the extracellular matrix are made up of elastin proteins which co-polymerize with fibrillin forming fiber ... The principal protein is elastin. Elastic cartilage is histologically similar to hyaline cartilage but contains many yellow ...

https://en.wikipedia.org/wiki/Elastic_cartilage

Elastic microfibril and elastin. extracellular matrix Reticular fibers. Form a scaffolding for other cells. Type III collagen. ... made from elastin and fibrillin, also provide resistance to stretch forces.[16]:171 They are found in the walls of large blood ...

https://en.wikipedia.org/wiki/Fibrous_connective_tissue

Elastin microfibril interfacer 1 (EMILIN-1) is a protein that in humans is encoded by the EMILIN1 gene. It is the best ... "Entrez Gene: EMILIN1 elastin microfibril interfacer 1". CS1 maint: discouraged parameter (link) Doliana R, Mongiat M, Bucciotti ... 2000). "Structure, chromosomal localization, and promoter analysis of the human elastin microfibril interfase located proteIN ( ...

https://en.wikipedia.org/wiki/EMILIN1

The enzyme degrades soluble and insoluble elastin. The gene is part of a cluster of MMP genes which localize to chromosome ...

https://en.wikipedia.org/wiki/Matrix_metallopeptidase_12

elastin: a vertebrate protein Deming T (2012). Peptide-Based Materials. Springer Publishing. Neurath H (1966). The Proteins ... The PPII structure widely exists in elastomeric proteins, such as abductin, elastin, and titin. It is believed to contribute in ... Rubber like proteins, such as resilin and elastin, are characterized based on their high resilience, low stiffness, and large ...

https://en.wikipedia.org/wiki/Resilin

Substrates include elastin, fibronectin, Col IV MMP13. Collagenase 3. CLG3, MANDP1, MMP-13. secreted. Substrates include Col I ... Substrates include Col IV, laminin, fibronectin, elastin MMP11. Stromelysin 3. SL-3, ST3, STMY3. secreted. MMP-11 shows more ...

https://en.wikipedia.org/wiki/Matrix_metalloproteinase

... is a lysine derivative found in elastin. Isodesmosine is an isomeric pyridinium-based amino acid resulting from ... These represent ideal biomarkers for monitoring elastin turnover because these special cross-links are only found in mature ... elastin in mammals. Desmosine Miao, M.; Bruce, A.E.E.; Bhanji, T.; Davis, E.C.; Keeley, F.W. (2007). "Differential expression ... the condensation of four lysine residues between elastin proteins by lysyl-oxidase. ...

https://en.wikipedia.org/wiki/Isodesmosine

PMID 19714629.(cited 29 times) Nettles, DL; Chilkoti, A; Setton, LA (2010). "Applications of elastin-like polypeptides in ... "In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect ... "Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide". Biomaterials. 27 (1): 91- ... "Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 ...

https://en.wikipedia.org/wiki/Lori_Ann_Setton

The main structural proteins are collagen and elastin. This causes thinning and the wall balloons allowing gross enlargement to ...

https://en.wikipedia.org/wiki/Atheroma

Degradation of elastin, starch and casein is positive. Strains SPS-243T, RQ-10 and RQ-12 utilize D-glucose, D-fructose, D- ...

https://en.wikipedia.org/wiki/Meiothermus_timidus

"Quantitative Observation of Backbone Disorder in Native Elastin". Journal of Biological Chemistry. 279 (9): 7982-7. doi:10.1074 ...

https://en.wikipedia.org/wiki/Fuzzy_complex

They concluded with relative certainty that the pyridine cross-links found in elastin were, in fact, due to an in-vivo ... Umeda, H.; Takeuchi, M.; Suyam, K. (2001). "Two New Elastin Cross-links Having Pyridine Skeleton". Journal of Biological ... Researchers found that protein-incorporated allysine, (deaminated lysine) from bovine ligamentum nuchae elastin fibers appeared ... Extrapolating from an in-vitro elastin model under physiological conditions, the researchers found that the ratios of IDP to ...

https://en.wikipedia.org/wiki/Chichibabin_pyridine_synthesis

It consists of loose connective tissue and elastin. The main cell types are fibroblasts, macrophages and adipocytes (the ...

https://en.wikipedia.org/wiki/Skin

"프리스틴 (PRISTIN) - HI! PRISTIN (The 1st Mini Album) [Ver B. Elastin]". 리스뮤직 (in Korean). Retrieved 2017-08-30. "[팝's신곡]"파워 & 프리티 ... Physically, the album received two versions, Prismatic and Elastin, the words that originated the name Pristin. The first ...

https://en.wikipedia.org/wiki/Hi!_Pristin

... is associated with deficient or absent elastin fibers in the extracellular matrix. This can be related to decreased ... It has also been considered that mutations in elastin (ELN) and fibulin-5 (FBLN5) genes can increase susceptibility of elastic ... 2016-02-13). "Acquired Localized Cutis Laxa due to Increased Elastin Turnover". Case Reports in Dermatology. 8 (1): 42-51. doi: ... 2016-02-13). "Acquired Localized Cutis Laxa due to Increased Elastin Turnover". Case Reports in Dermatology. 8 (1): 42-51. doi: ...

https://en.wikipedia.org/wiki/Cutis_laxa

The elastin receptor complex includes S-Gal, neuraminidase and Cathepsin A. When elastin-derived peptides bind to the S-Gal ... The S-Gal protein does bind elastin and fragments of elastin that are generated by proteolysis. The S-Gal protein is a ... The ability of the GLB1-derived elastin binding protein and the elastin receptor complex to influence cell proliferation ... The S-Gal protein functions during the normal assembly of elastin into extracellular elastic fibers. Elastin is initially ...

https://en.wikipedia.org/wiki/GLB1

The elastin on the other hand is a protein that allows for flexibility. These two elements of the nuchal ligament maintain a ... The yellow colour is the elastin on the ligaments.) The name is derived from the corruption of paxwax (originally faxwax Old ... the nuchal ligament is formed with the association of both elastin proteins as well as type III collagen (45%). The collagen ...

https://en.wikipedia.org/wiki/Paddywhack

Bristow J, Carey W, Egging D, Schalkwijk J (2005). "Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome". Am J Med ...

https://en.wikipedia.org/wiki/Tenascin

The process of coacervation is thought to be essential for proper elastin assembly in the ECM. Coacervation must occur outside ... Epidermal samples from the same patient subjected to electron microscopy revealed that elastin fibers display abnormally high ... The skin's elastic fiber system consists of elastin (which is normally non-glycosylated) and glycosylated proteins (fibulin, ... Elastin is not required for brain or bone growth. However, it is believed that abnormal/impaired secretion of the brain and ...

https://en.wikipedia.org/wiki/Wrinkly_skin_syndrome

The human lung contains large quantities of collagen and elastin, proteins that allow for tissue flexibility. Aspergillus ... Rosenbloom J (December 1984). "Elastin: relation of protein and gene structure to disease". Laboratory Investigation; A Journal ... fumigatus produces and secretes elastases, proteases that cleave elastin in order to break down these macromolecular polymers ...

https://en.wikipedia.org/wiki/Aspergillus_fumigatus

Bristow J, Carey W, Egging D, Schalkwijk J (2005). "Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome". American ... Goepel C (2008). "Differential elastin and tenascin immunolabeling in the uterosacral ligaments in postmenopausal women with ...

https://en.wikipedia.org/wiki/Tenascin_X

Elastin-like polypeptides (ELPs) are a useful tool in biotechnology. Fused with target protein, they tend to form aggregates ...

https://en.wikipedia.org/wiki/Protein_splicing

Sheldon Hendler on IMDB Kornberg, RL; Hendler, SS; Oikarinen, AI; Matsuoka, LY; Uitto, J. "Elastoderma--disease of elastin ...

https://en.wikipedia.org/wiki/Sheldon_Saul_Hendler

Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing ... "Elastin (ELN)". Retrieved 31 October 2011.. *^ Muiznieks LD, Weiss AS, Keeley FW (Apr 2010). "Structural disorder and dynamics ... Elastin is also very important in the lungs, elastic ligaments, elastic cartilage, the skin, and the bladder. It is present in ... Elastin is a highly elastic protein in connective tissue and allows many tissues in the body to resume their shape after ...

https://en.wikipedia.org/wiki/Elastin

elastin* A fibrous protein that is the major constituent of the yellow elastic fibres of connective tissue [1]. It is rich in ... elastin A fibrous protein that is the major constituent of the yellow elastic fibres of connective tissue. It is rich in ... elastin A Dictionary of Food and Nutrition © A Dictionary of Food and Nutrition 2005, originally published by Oxford University ... elastin Insoluble protein in connective tissue, which is not affected by cooking; the cause of tough meat.. ...

https://www.encyclopedia.com/sports-and-everyday-life/food-and-drink/food-and-cooking/elastin

Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4767

Elastin is a rubber,rubberlike protein with fibres that can stretch to many times their normal length. It is a highly ... Elastin is a rubberlike protein with fibres that can stretch to many times their normal length. It is a highly hydrophobic ... Elastin networks in the extracellular matrix are essential for the functioning of such organs as lungs, skin and blood vessels ... Elastin is predominantly composed of small, non-polar amino acids, with the smallest of the amino acids, Glycine making up one ...

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Elastin-like polypeptides (ELPs) are synthetic biopolymers with potential applications in the fields of cancer therapy, tissue ... Tropoelastin is a protein, of size 72kDa, that comes together via cross-links to form elastin in the extracellular matrix of ... One of the major reasons that elastin can withstand high levels of stress in the body without experiencing any physical ... March 2015). "Fabricated Elastin." Advanced Healthcare Materials. 4(16): 2530-2556. Retrieved 15 May 2017. Christensen, T; ...

https://en.wikipedia.org/wiki/Elastin-like_polypeptides

The degradation of elastin by elastase-type enzymes was shown to play an important role in several pathological processes such ... are able to hydrolyze elastin and release soluble peptides. The released peptides (mainly kappa elastin, KE) were shown to have ... The degradation of elastin by elastase-type enzymes was shown to play an important role in several pathological processes such ... Rabbits immunized with elastin peptides were shown to develop severe arteriosclerosis (Robertet al., 1971; Jacobet al., 1984) ...

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Pulmonary Emphysema Entire Lung Leukocyte Elastase Pancreatic Elastase Elastin Content These keywords were added by machine and ... Mandl I., Darnule T.V., Fierer J.A., Keller S., Turino G.M. (1977) Elastin Degradation in Human and Experimental Emphysema. In ... Work in progress is designed to distinguish the peptides resulting from digestion of human lung elastin by these enzymes on the ... In support of this mechanism we show (1) by biochemical analysis - that elastin content of connective tissue has been decreased ...

https://link.springer.com/chapter/10.1007/978-1-4684-9093-0_19

Research in elastin preservation and regeneration may be the key to future longevity.. Dr. Vyavahare is a Hunter Endowed Chair ...

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News-Medical.Net provides this medical information service in accordance with these terms and conditions. Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. ...

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Restoring Elastin In Skin Isnt As Hard As You Might Think - Provided You Use The Right Ingredients. 17th June 2009 ... Natural Skincare Ingredients Can Re-Build Collagen And Elastin. 13th February 2009 ...

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Elastins persistence and insolubility hampered early efforts to construct versatile biomaterials. Subsequently the field has ... Elastin is a versatile elastic protein that dominates flexible tissues capable of recoil, and facilitates commensurate cell ... Elastin-based materials† Jessica F. Almine,a Daniel V. Bax,a Suzanne M. Mithieux,a Lisa Nivison-Smith,a Jelena Rnjak,a Anna ... Subsequently the field has progressed substantially through the adapted use of solubilized elastin, elastin-based peptides. and ...

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1984), are able to hydrolyze elastin and release soluble peptides. (springer.com)
The released peptides (mainly kappa elastin, KE) were shown to have a variety of biological properties (Robert et al . (springer.com)
Rabbits immunized with elastin peptides were shown to develop severe arteriosclerosis (Robert et al . (springer.com)
1987). Our aims were to investigate the effects of elastin peptides on ion fluxes and to elucidate their mechanism of action at the cellular and intracellular levels. (springer.com)
Work in progress is designed to distinguish the peptides resulting from digestion of human lung elastin by these enzymes on the basis of differences in their precipitating anti bodies. (springer.com)
Subsequently the field has progressed substantially through the adapted use of solubilized elastin, elastin-based peptides and the increasing availability of recombinant forms of the natural soluble elastin precursor, tropoelastin. (rsc.org)
Here we demonstrate the fabrication of a fusion protein comprising of elastin-like peptides and KGF. (pnas.org)
It also preserved the characteristic elastin-like peptides inverse phase transitioning allowing the recombinant protein to be expressed in bacterial hosts (such as Escherichia coli ) and purified rapidly and easily using inverse temperature cycling. (pnas.org)
This includes scaffolds of collagen and solubilized elastin ( 17 ), dermal substitutes coated with 3% α-elastin ( 6 , 18 ), and alginate wound dressings linked with hybrid peptides of elastin ( 19 ). (pnas.org)
Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway. (semanticscholar.org)
We studied the effects of elastin-derived peptides (EDPs), biomarkers of aging, on NAFLD progression. (diabetesjournals.org)
Migration of the chorioretinal endothelial cell line RF/6A in response to elastin peptides was assessed in the presence of inhibitors of two elastin receptors, ITGAV/ITGB3 and GLB1. (arvojournals.org)
Chorioretinal endothelial cells increase migration in the presence of elastin fragments and this response is inhibited by both GLB1 and ITGAV/ITGB3 antagonists, indicating that both proteins may be endothelial cell receptors for elastin peptides. (arvojournals.org)
Determining the mechanism by which elastin peptides bind to and activate choroidal endothelial cells will further our understanding of AMD pathology. (arvojournals.org)
Elastin-like peptides (ELPs) are well suited for solution-based biomedical applications, including drug delivery and biomolecular purification. (aps.org)
Microplates were coated with human lung elastin peptides (Elastin Products Company, Owensville, MO, USA) or with PBS (control wells) overnight, then washed and blocked. (ersjournals.com)
We have found that the cell penetrating peptides (CPP) Tat or penetratin (Pen), fused with elastin-like polypeptide (CPP-ELP) inhibited adhesion, spreading, invasion and migration of SKOV-3 ovarian cancer cells, SK-MEL-2 melanoma cells, and MDA-MB-231 breast cancer cells in cell culture. (aacrjournals.org)

In the body, elastin is usually associated with other proteins in connective tissues. (wikipedia.org)
Why We (Love) Collagen & Elastin: Collagen and elastin proteins are naturally present in healthy skin. (wegmans.com)
Collagen and elastin are naturally occurring structural proteins normally produced in the dermis , the middle layer of the skin. (wisegeek.com)
An important focus will also be novel approaches and analytical tools for investigating elastin and associated proteins in health and disease, and translational approaches for tissue engineering and regenerative medicine. (grc.org)
After a genome-wide search for quantitative trait loci (QTL) influencing the aortic elastin, collagen, and cell protein contents in an F2 population derived from BN and LOU rats, we identified on chromosomes 2 and 14, 3 QTL specifically controlling elastin levels, and a further highly significant QTL on chromosome 17 linked to the level of cell proteins. (ahajournals.org)
Elastin and collagens are the main extracellular matrix proteins of blood vessels. (ahajournals.org)
Assembly of polymeric elastin into its final architecture in the extracellular matrix involves both self-aggregation properties of its monomeric precursor, tropoelastin, and interactions with several matrix-associated proteins that appear to act by modulating the intrinsic self-assembly of tropoelastin. (sigmaaldrich.com)
Over the past decade a number of reports have described the design of synthetic genes, which encode elastin-like proteins (ELP) for bacterial expression in Escherichia coli . (pubmedcentralcanada.ca)
For example, recombinant silk-elastin proteins have been successfully expressed in tobacco and potato plants 12 . (pubmedcentralcanada.ca)
Additionally, the expression of a variety of target proteins in transgenic tobacco has been enhanced by an order of magnitude when fused to elastin-like polypeptides 13 - 15 . (pubmedcentralcanada.ca)
Elastins and collagens are proteins that are too large to penetrate the surface of the skin. (udym.com)
With 100% naturally sourced moisturizers blended with collagen & elastin proteins, this non-greasy lotion absorbs quickly to help restore and rejuvenate skin. (stives.com)

Elastin is made by linking together many small soluble precursor tropoelastin protein molecules (50-70 kDa ), to make the final massive insoluble, durable complex. (wikipedia.org)
The unlinked tropoelastin molecules are not normally available in the cell, since they become crosslinked into elastin fibres immediately after their synthesis by the cell and during their export into the extracellular matrix . (wikipedia.org)
To make mature elastin fibres, the tropoelastin molecules are cross-linked via their lysine residues with desmosine and isodesmosine cross-linking molecules. (wikipedia.org)
The feasibility of using recombinant human tropoelastin to enable elastin fiber production to improve skin flexibility in wounds and scarring has been studied. (wikipedia.org)
Tropoelastin is a protein, of size 72kDa, that comes together via cross-links to form elastin in the extracellular matrix of the cell. (wikipedia.org)
One of the major reasons that elastin can withstand high levels of stress in the body without experiencing any physical deformation is that the underlying tropoelastin contains domains that are highly hydrophobic. (wikipedia.org)
Tropoelastin is the soluble precursor form of elastin. (pnas.org)
We previously demonstrated that the inbred Brown Norway (BN) rat shows an aortic elastin deficit in both abdominal and thoracic segments, partly because of a decrease in tropoelastin synthesis when compared with the LOU rat, that elastin gene polymorphisms in these strains do not significantly account for. (ahajournals.org)
7 The aortic elastin deficit in the BN rat is, at least in part, caused by decreased tropoelastin synthesis during the period of rapid growth. (ahajournals.org)
Elastin binding protein and FKBP65 modulate in vitro self-assembly of human tropoelastin. (sigmaaldrich.com)
Elastin is made by linking many soluble tropoelastin protein molecules, in a reaction catalyzed by lysyl oxidase, to make a massive insoluble, durable cross-linked array. (acris-antibodies.com)
Here we describe the production and properties of massive synthetic elastin assemblies formed by chemically cross-linking recombinant human tropoelastin with bis(sulfosuccinimidyl) suberate, permitting the construction of elastic sponges, sheets and tubes. (nih.gov)

Elastin is a highly elastic protein in connective tissue and allows many tissues in the body to resume their shape after stretching or contracting. (wikipedia.org)
elastin A fibrous protein that is the major constituent of the yellow elastic fibres of connective tissue . (encyclopedia.com)
Elastin is a rubberlike protein with fibres that can stretch to many times their normal length. (everything2.com)
Elastin is a key protein of the extracellular matrix. (wikipedia.org)
Elastin is a very long-lived protein, with a half-life of over 78 years in humans. (wikipedia.org)
Elastin-like polypeptides (ELPs) are synthetic biopolymers with potential applications in the fields of cancer therapy, tissue scaffolding, and protein purification. (wikipedia.org)
Elastin is the extracellular protein responsible for elasticity in vertebrates. (hindawi.com)
Elastin is a versatile elastic protein that dominates flexible tissues capable of recoil, and facilitates commensurate cell interactions in these tissues in all higher vertebrates. (rsc.org)
Full length native protein (insoluble alpha elastin purified from human aorta by hot sodium hydroxide). (abcam.com)
This protein component is also released from the surface of cultured chondroblasts by incubation with lactose, and its association with immobilized elastin is inhibited by lactose. (sciencemag.org)
Elastin is the second most abundant protein in the body. (lorealparisusa.com)
The subject of the invention is an elastin-based product consisting of an adduct containing elastin and at least one protein which can be coagulated and/or activated by thrombin. (google.co.uk)
This fusion protein retains the performance characteristics of KGF and elastin as evidenced by its enhancement of keratinocyte and fibroblast proliferation. (pnas.org)
As a remarkably long-lived protein, elastin can suffer from cumulative effects of exposure to biochemical damages, which can greatly compromise its biomechanical properties. (sigmaaldrich.com)
Elastin is a heichly elastic protein in connective tishie an allous mony tishies in the bouk tae resume thair shape efter stretchin or contractin. (wikipedia.org)
Elastin is a polymeric protein and is the main component of the extracellular matrix of arteries. (fishersci.com)
In this study, we have performed a genetic analysis in an F2 cohort of 161 rats derived from BN and LOU rat strains to detect genetic loci contributing to quantitative variations of aortic elastin, collagen, and cell protein contents and to test a possible relationship between these loci and those linked to susceptibility to aortic IEL ruptures. (ahajournals.org)
Fractionation of BAL fluid from wild-type mice found that elastin fragments were the only matrix protein fragments present in the chemotactic fraction of the fluid. (bmj.com)
Elastin is a protein that provides the unusual properties of extensibility and elastic recoil to tissues. (sigmaaldrich.com)
Both the elastin binding protein (EBP) and FKBP65 have been suggested to fulfill that role in the Golgi and endoplasmic reticulum compartments of the cell, respectively. (sigmaaldrich.com)
Elastin is an important polymeric protein of connective tissue that imparts elasticity to vertebrate elastic tissues. (acris-antibodies.com)
Elastin is the body's naturally occurring elastic protein and Prof. Weiss and his research group have depended on confocal and scanning electron microscopy in the AMMRF at the University of Sydney to develop and improve their elastin products. (ammrf.org.au)
Western blot and immuno-staining confirmed expression of elastin protein. (ahajournals.org)
Seven days after coronary artery ligation, BMSCs transfected with genes for either adeno-elastin (BMSC+Elastin) or adeno-green fluorescence protein (BMSC), or media (control group) were injected into the infarct area of adult rats (n=8/group). (ahajournals.org)
In this report, we describe a modified concatemerization strategy to construct a gene with enhanced sequence diversity that encodes a highly repetitive elastin-like protein polymer for expression in Pichia pastoris . (pubmedcentralcanada.ca)
A fusion protein consisting of a self-cleaving intein and a precipitation tag known as Elastin-Like Peptide (ELP) is one possible purification scheme for increasing the yield of active antimicrobial peptide. (osu.edu)

Collagen, elastin, and hyaluronic acid are the essential building blocks of skin. (neocutis.com)
The lines on this chart represent when and how quickly collagen, elastin, and hyaluronic acid typically break down. (neocutis.com)
Depletion of collagen and hyaluronic acid happens before elastin loss. (neocutis.com)
Elastin, Hyaluronic Acid, Squalane and Aloe provide the perfect combination for delivering results. (pevonia.co.uk)

Elastin networks in the extracellular matrix are essential for the functioning of such organs as lungs , skin and blood vessels which require strong but elastic tissue . (everything2.com)
Elastin-rich lung extracellular matrix is largely remodeled during tumor invasion. (semanticscholar.org)
Extracellular matrix molecules such as elastin and collagens provide mechanical support to the vessel wall. (ahajournals.org)
The composition of the arterial extracellular matrix and the adaptative synthesis of elastin and collagen in hypertension may also influence the degree of reversibility of arterial remodeling in response to antihypertensive treatment and the development of hypertensive arteriopathy. (ahajournals.org)
MMP-12 degrades lung extracellular matrix components and generates the production of elastin fragments that are chemotactic to monocytes and which drive disease progression. (bmj.com)
Over-expression of elastin in transplanted BMSCs contributed to the alignment and organization of an elastic extracellular matrix structure, which prevented cardiac dilatation and dysfunction. (ahajournals.org)
Elastin plays a key role in the remodeling of the extracellular matrix. (ahajournals.org)

It is thought that elastin has a random coil formation in its "relaxed" state which can be stretched out while cross-links between chains hold the molecules together and collagen fibrils are interwoven with the fibres to limit stretching and prevent tearing. (everything2.com)
In addition elastin fibres are covered with a sheath of microfibrils composed of glycoproteins such as fibrillin which are required for assembly and to maintain the integrity of the fibre. (everything2.com)
The Elastin Sports Tape is constructed from a combination of a special cotton fibres and mucus coating which allows adhesive. (fuzing.com)
Methods The authors measured cutaneous elastin degradation using immunohistochemistry (percentage area of elastin fibres) in sun-exposed (exposed) and non-sun-exposed (non-exposed) skin biopsies in 16 men with COPD and 15 controls matched for age and cigarette smoke exposure. (bmj.com)
and 3) typical elastic fibres consisting of microfibrils and abundant elastin. (lymphedemapeople.com)

There are, however, only scant data on the role of elastin and its receptors in tumor invasion. (nih.gov)
So it was that the role of elastin in skin and aging came to mind again. (fightaging.org)
The attached abstract explains the role of elastin in lymph capillaries, A fibrillar elastic apparatus around human lymph capillaries. (lymphedemapeople.com)

Zinc, typically found in meats, dairy products, and seafood, is believed crucial for the maintenance of elastin fibers. (wisegeek.com)
Frances, C. and Robert, L. Elastin and elastic fibers in normal and pathologic skin. (lorealparisusa.com)
The Gordon Research Seminar on Elastin, Elastic Fibers and Microfibrils is a dynamic research forum for graduate students, post-docs and early career scientists at the forefront of elastic fiber-related research to present their own cutting-edge findings and exchange ideas amongst their peers, as well as established faculty in the field. (grc.org)
This meeting encourages young scientists from a broad range of backgrounds and interests to lead discussions on topics including the structure and assembly of elastin, elastic fibers and microfibrils, elastic tissue mechanics and mechanisms of development and aging, as well as matrix regulation of cell signaling. (grc.org)
This GRS will be held in conjunction with the "Elastin, Elastic Fibers and Microfibrils" Gordon Research Conference (GRC). (grc.org)
Collagen and elastin are fibers that make up the supporting structure of the skin. (sharecare.com)
The only way to boost collagen and elastin in the skin is to turn on the fibroblast cells that produce these fibers. (sharecare.com)
Elastin is a major constituent of skin elastic fibers and may be beneficial for dermal regeneration ( 16 ). (pnas.org)
During aging, the elasticity of connective tissue is reduced because of the cross-linking of collagenous fibers with elastin. (fishersci.com)
Elastic fibers composed of an elastin core surrounded by microfibrils are designed to maintain elastic function in tissues such as blood vessels, lungs, and skin. (ahajournals.org)
The quiz and worksheet help you check your understanding of comparing collagen and elastin fibers. (study.com)
You can review more topics by going through the lesson called Collagen vs. Elastin Fibers. (study.com)
Their activities must be counteracted with antioxidants or they will harm the cellular membrane along with the collagen, elastin fibers and cell DNA. (udym.com)
Elastin - the elastic fibers found between the collagen fibers, responsible for the firmness of the skin. (catcosmetics.com)

[4] Other associated defects in elastin include Marfan syndrome , emphysema caused by α 1 -antitrypsin deficiency, atherosclerosis , Buschke-Ollendorff syndrome , Menkes syndrome , pseudoxanthoma elasticum , and Williams syndrome . (wikipedia.org)
The enzymes responsible for degradation of pulmonary elastin have not been established but three possibilities will be discussed: Polymorphonuclear leukocyte elastase which in phenotypical ly normal (α 1 -antitrypsin) MM subjects has been found to be present in statistically significantly higher amounts in patients with emphysema as compared with normal human subjects (2) alveolar macrophage elastase (3) specific tissue elastases. (springer.com)
Mandl I., Darnule T.V., Fierer J.A., Keller S., Turino G.M. (1977) Elastin Degradation in Human and Experimental Emphysema. (springer.com)
Background Development of emphysema and vascular stiffness in chronic obstructive pulmonary disease (COPD) may be due to a common mechanism of susceptibility to pulmonary and systemic elastin degradation. (bmj.com)
In the entire cohort of ex-smokers, cutaneous elastin degradation was associated with emphysema severity, FEV 1 and pulse wave velocity. (bmj.com)
Conclusions Patients with COPD have increased skin elastin degradation compared with controls, which is related to emphysema severity and arterial stiffness. (bmj.com)
Men with chronic obstructive pulmonary disease (COPD) have increased skin elastin degradation compared with controls matched for age and smoking history, and this was associated with arterial stiffness and emphysema severity. (bmj.com)
Elastin fragments drive disease progression in a murine model of emphysema. (bmj.com)
Immunological processes and especially autoreactive immune processes have recently been implicated, with anti-elastin antibodies and a T-helper type-1 lymphocyte response identified in patients with COPD/emphysema 1 . (ersjournals.com)
We explored whether an autoimmune process implicating anti-elastin autoantibodies and facilitated by tobacco smoking may take place in patients with combined pulmonary fibrosis and emphysema (CPFE), a distinct entity recently defined on the basis of characteristic features of chest imaging, pulmonary function and outcome 4 . (ersjournals.com)
Quantification of anti-elastin antibodies using ELISA in patients with combined pulmonary fibrosis and emphysema (CPFE) and controls. (ersjournals.com)
Our results do not support the idea that either emphysema or fibrosis in CPFE may be mediated by an autoimmune process directed against elastin. (ersjournals.com)
Since all patients with CPFE had emphysema on imaging (mostly paraseptal emphysema, and also centrolobular emphysema), our results also fail to confirm the presence of circulating anti-elastin antibodies in patients with emphysema (at least when associated with fibrosis). (ersjournals.com)

Intoxication of rats with mercuric chloride (0.5 mg Hg/kg of body weight, daily for 10 weeks) increased the hepatic contents of soluble and insoluble collagen and elastin. (srce.hr)
These new techniques, as well as some previously published by other workers, were evaluated with the help of antiserum raised in sheep against insoluble chick elastin. (biochemj.org)

Biochemical analysis detected over-expression of recombinant elastin, and histological examination revealed that collagen fiber length and diameter were preserved in the scar tissue. (ahajournals.org)

Elastin's primary structure consists of alternating hydrophobic segments (supposedly responsible for the protein's elasticity) and alanine and lysine-rich alpha helical segments responsible for cross-linking with adjacent elastin molecules. (everything2.com)
While there are lots of collagen and elastin creams available these molecules are far too large to penetrate the skin. (sharecare.com)
The functionalization process has led to an effective attachment of collagen and elastin-like recombinamer (ELR) molecules. (upc.edu)
Collagen and elastin molecules are too large to penetrate through your skin surface. (bestofmissourihands.com)

We already know all about Elastatropin in our B and E versions: that it helps to reduce the onset and appearance of wrinkles, small amounts applied daily in early adulthood can maintain a youthful level of elastin while older consumers through continued regular application can eventually replenish elastin and protect against new wrinkles. (bio-medicine.org)
Now continuous use of Bx Pro/Face for one year with higher doses of Elastatropin will diminish wrinkles even further as it provides six times the amount of elastin lost in that year. (bio-medicine.org)
Simultaneously, Elastin-rp stimulates the skin's natural healing ability and facilitates faster skin turnover to give you more supple and more elastic skin that is firmer and less prone to developing wrinkles and other signs of aging. (consumerhealthdigest.com)
Elastin-rp is made with a unique combination of active ingredients through the BioLastin Complex that supports improved skin elasticity which, in turn, makes fine lines and wrinkles much less visible. (consumerhealthdigest.com)

In: Sandberg L.B., Gray W.R., Franzblau C. (eds) Elastin and Elastic Tissue. (springer.com)

Elastin serves an important function in arteries as a medium for pressure wave propagation to help blood flow and is particularly abundant in large elastic blood vessels such as the aorta . (wikipedia.org)
Genetically determined minor modifications in elastin and collagen in the aorta could influence the onset and evolution of arterial pathology, such as hypertension and its complications. (ahajournals.org)
The inbred Brown Norway (BN) rat strain shows an aortic elastin deficit (by 5.8% dry weight when compared with the inbred LOU rat) 5,6 and is also highly susceptible to spontaneous rupture of the internal elastic lamina (IEL) in its abdominal aorta. (ahajournals.org)
Elastin is particularly abundant in large elastic blood vessels such as the aorta. (acris-antibodies.com)

Our Collagen Elastin is a powerful smart-aging serum to ward off the signs of aging to maintain healthy + youthful skin! (pureandsimple.ca)
With 5% marine collagen + elastin, this high performing, lightweight serum rebuilds your skin's collagen + supports natural collagen production, making it a highly effective anti-aging product. (pureandsimple.ca)
and that being said, is there a C serum out there that contains ingredients that support elastin production? (smartskincare.com)
Feine Linien und Fältchen können Sie mit dem Declaré Collagen & Elastin Booster Serum lindern. (parfumdreams.de)

EWG scientists reviewed St. Ives Body Lotion, Skin Renewing Collagen Elastin (2014 formulation) for safety according to the methodology outlined in our Skin Deep Cosmetics Database. (ewg.org)

Volume I explains elastin, its biosynthesis, physicochemical properties, and alteration in a variety of pathologies and with aging. (routledge.com)

Elastin Monoclonal antibody specifically detects Elastin in Human samples. (fishersci.com)
The use of an elastin fragment antibody resulted in monocyte chemotaxis inhibition, even in the presence of cigarette smoke. (bmj.com)
Elastin fragment inhibition by elastin fragment antibody reduced lung macrophage accumulation and airspace disease in this model. (bmj.com)

Objectives To investigate whether patients with COPD have evidence of systemic elastin degradation in the skin. (bmj.com)
Systemic elastin degradation due to increased proteolytic activity may represent a novel shared mechanism for the pulmonary, vascular and cutaneous features of COPD. (bmj.com)
Is systemic elastin degradation the mechanism of increased arterial stiffness and skin wrinkling in chronic obstructive pulmonary disease? (bmj.com)
Systemic elastin degradation due to increased proteolytic activity may represent a novel shared mechanism for the pulmonary, vascular and cutaneous features of chronic obstructive pulmonary disease. (bmj.com)
Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis. (semanticscholar.org)

In skincare, elastin products are most commonly found in the form of moisturizers (i.e. elastin cream). (lorealparisusa.com)
Elastin Collagen Cream BACK IN STOCK! (catcosmetics.com)
This is the exact same Elastin Collagen Cream, only the packaging and the name has had a face lift! (catcosmetics.com)
Anti-aging day cream with Collagen, Elastin and Jojoba. (catcosmetics.com)
Elastin Collagen Cream! (catcosmetics.com)
Collagen and elastin found in cream products cannot fuse properly with the collagen and elastin found in your skin. (bestofmissourihands.com)

Compared to the B and E versions of DermaLastyl currently available, the Bx Pro/Face formula contains higher doses of Elastatropin equal to six times the amount of elastin being lost in one year. (bio-medicine.org)

Here is a study that says vitamin c and derivatives DO promote synthesis of elastin, in fact it says that MAP strongly promotes synthesis of elastin. (smartskincare.com)

In previous studies 'anchoring filaments' of human lymphatic capillaries have been shown to consist of microfibrils having histochemical and ultrastructural characteristics similar to elastin-associated microfibrils. (lymphedemapeople.com)
When not associated with an elastin component, these microfibrils are referred to as 'oxytalan microfibrils. (lymphedemapeople.com)

Elastic fiber in the body is a mixture of amorphous elastin and fibrous fibrillin . (wikipedia.org)
Elastin is considered an essential building block of the fibrous tissue that keeps skin flexible and elastic. (wisegeek.com)

Elastin is one of the most recommended proteinic ingredients to revitalize and tighten the skin while improving elasticity and suppleness. (pevonia.co.uk)
Elastin-rp Ingredients - Are they Safe & Effective? (consumerhealthdigest.com)
The use of nutrients and naturally occurring ingredients that stimulate the growth of collagens is prevalent in the current collagen elastin therapy. (udym.com)

We evaluated the consequences of EDP accumulation in mice and of elastin receptor complex (ERC) activation on lipid storage in hepatocytes, inflammation, and fibrosis development. (diabetesjournals.org)
We tested this hypothesis by determining smooth muscle extension and elastin accumulation along pulmonary arteries (PAs) and veins (PVs) in 3 groups of lambs. (nature.com)
Muscularization of PAs and elastin accumulation in PAs and PVs may contribute to the histologic and extravascular lung water content evidence of pulmonary edema, and the sustained PVR by increasing the filtration pressure and resistance along the pulmonary microcirculation. (nature.com)
Some people believe that it could prevent the accumulation of elastin that is seen in photoaged skin. (smartskincare.com)

Various foods are considered capable of helping the skin to maintain youthful collagen and elastin levels. (wisegeek.com)
Elastin: Healthy levels of Elastin help preserve the elasticity and firmness of youthful skin. (vitasprings.com)

The elastin receptor complex contains a component of 67 kilodaltons that binds to a glycoconjugate affinity column containing beta-galactoside residues and is eluted from this column with lactose. (sciencemag.org)
Since lactose also blocks elastic fiber formation by cultured chondroblasts, the galactoside-binding property of the elastin receptor is implicated in this process. (sciencemag.org)
Putative role of 67 kDa elastin-laminin receptor in tumor invasion. (nih.gov)
Nevertheless, experimental evidence indicates that the 67 kDa elastin-laminin receptor (ELR) subunit plays an important role in tumor invasion by mediating essential tumor cell functions leading to metastases. (nih.gov)
Our current investigation aims to determine the effects of elevated elastin fragments in vivo and to identify the possible endothelial cell receptor(s) responsible for this activity. (arvojournals.org)

Collagen and elastin are the structure of the skin that maintains both elasticity and firmness. (sharecare.com)
Collagen gives skin its firmness while elastin keeps skin tight. (sharecare.com)
Suitable for all skin types, the Elastin Wet Collagen Eye Mask is blended with vitamins, acids, and extracts to restore the skin's natural moisture and give firmness to the delicate muscles around the eye area. (universalcompanies.com)

The purpose of this study is to investigate the effects of glucose on mechanical properties of isolated porcine aortic elastin. (sigmaaldrich.com)
5 Because the elastin gene polymorphism explains only a small part of differences between parental strains, it is thus probable that other genes account for the major proportion of the interstrain differences in aortic elastin content. (ahajournals.org)

Best results when used after the Firming Marine Elastin Concentrate. (pevonia.co.uk)

Biochemistry of Collagens, Laminins and Elastin Edition by Morten Karsdal and Publisher Academic Press. (vitalsource.com)
There are many effective collagen skin remedies that do not even contain use of any collagens and elastins. (udym.com)
Many 'bio-available' collagen elastin skin remedies can give relief from itching, reduce redness, heal dermatitis and inflammation of skin along with increasing the cells and collagens that are present in the body. (udym.com)

In this work, we present a novel method for visualization of local temperature increase using elastin-like polypeptides (ELP). (rsc.org)

[9] Comparison between fresh and digested tissues shows that, at 35% strain, a minimum of 48% of the arterial load is carried by elastin, and a minimum of 43% of the change in stiffness of arterial tissue is due to the change in elastin stiffness. (wikipedia.org)
Effect of glucose on the biomechanical function of arterial elastin. (sigmaaldrich.com)
Elastin performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. (fishersci.com)
The elastin-null mice (ELN −/− ) die of obstructive arterial disease, 2 whereas the ELN +/− mice have reduced absolute quantities of elastin and are hypertensive, phenotypes similar to those observed in patients with supravalvular aortic stenosis and Williams syndrome. (ahajournals.org)
Investigating the genetic basis and pathophysiological consequences of the modulation of elastin levels, rather than the impact of absolute elastin deficit, is central to our understanding of mechanisms involved in arterial pathologies. (ahajournals.org)

Elastin is essential to provide elastic support for blood vessels. (sigmaaldrich.com)

Topical skin-care creams containing collagen and elastin are widely available from many manufacturers. (wisegeek.com)
Ideal for face & throat - it's infused with Vitamins A & E. Its elastin and collagen help prepare skin for application of active creams or serums used afterwards. (puritan.com)
Laser hair removal, collagen and elastin creams come up every time you ask any hip, urbane woman what they do to stay beautiful. (bestofmissourihands.com)

Anti-elastin antibodies were quantified using modified ELISA as previously described 1 . (ersjournals.com)

Dermatologists believe that these products, while often very moisturizing, don't actually increase collagen or elastin levels in the skin. (wisegeek.com)
I understand that there are many people who swear by C serums but if you look at this published study it is clear that C does increase collagen but elastin is decreased. (smartskincare.com)

Elevated elastin fragments promote choroidal endothelial cells to increase migration, a key event in neovascular age-related macular degeneration (AMD). (arvojournals.org)
Albino C57/BL 6 mice were injected intraperitoneally with elastin fragments or control saline 3x weekly for one month. (arvojournals.org)
No major ultrastructural differences were detected in eyes of mice injected with elastin fragments compared to control eyes. (arvojournals.org)
In vivo, elastin fragments cause a significant increase in the transcription of genes which may play a role in pathways associated with AMD. (arvojournals.org)
1 , exposure to tobacco smoking might increase secretion of proteolytic enzymes in the lung from cells of the innate immune system, thereby liberating lung elastin fragments and initiating elastin-targeted T- and B-cell mediated immunity in susceptible individuals. (ersjournals.com)

You can earn a 5% commission by selling GIGI COLLAGEN ELASTIN CONCENTRATE 50ml on your website. (fishpond.co.nz)

For fluorescence of elastin hydrolysates we observed both, a decrease and increase of this value during irradiation of the sample. (biomedsearch.com)
The fluorescence of elastin hydrolysates was observed at 305 nm and at 380 nm after excitation at 270 nm. (biomedsearch.com)
Intrinsic fluorescence spectroscopy demonstrated that the elastin fluorophore is a feature of the polypeptide. (nih.gov)

Elastosis is the buildup of elastin in tissues, and is a form of degenerative disease. (wikipedia.org)

Hinek, A.: Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren syndrome. (acris-antibodies.com)

Rosenbloom, J. : Molecular biology and pathology of human elastin. (acris-antibodies.com)

2. An elastin containing composition consisting essentially of a synthetic compound resulting from the reaction of fibrin monomers with elastin. (google.co.uk)
The innate characteristics of synthetic elastin constructs are common with those of native elastin. (nih.gov)
We conclude that synthetic elastin has potential as a novel biomaterial that can be easily molded into a variety of shaped tissue substrates and has a range of properties that are required for elastic, cell-interacting and compliant applications. (nih.gov)
Prof. Tony Weiss from the University of Sydney in conjunction with Elastagen Pty Ltd has been awarded a $1million Translation Award from the Wellcome Trust to fast track their elastin-based synthetic skin to clinical trials. (ammrf.org.au)

Elastin is particularly abundant in elastic cartilage , blood-vessel walls, ligaments, and the heart. (encyclopedia.com)

Full-length elastin cDNA was generated by PCR using the human lung cDNA library, and then transfected (in adenoviral vector) into rat bone marrow stromal cells (BMSCs). (ahajournals.org)

In humans, elastin is encoded by the ELN gene . (wikipedia.org)
In these patients, the elastin gene is mutated or deleted. (ahajournals.org)

1. An elastin containing composition comprising fibronectin and wherein elastin is covalently bound to fibrin monomers. (google.co.uk)
6. An elastin containing composition according to claim 1, further comprising at least one additive selected from the group consisting of collagen, thiourea, cellulose derivatives, calcium alginate, sodium ethylmercrylthiosalicylate, FVIII complex (antihemophilic A), the latter containing about 10 to 15 g/l of fibrinogen and about 2 to 4 g/l of fibronectin, von Willebrand factor, thrombospondin and laminin. (google.co.uk)
7. An elastin containing composition according to claim 2, wherein the elastin and fibrin monomers are of human origin. (google.co.uk)
10. An elastin containing composition according to claim 6, wherein said elastin containing composition is an adduct in the form of a cross-linked network. (google.co.uk)

Anatomy6

Diseases5

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes4

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena5

Technology, Industry, Agriculture4

Humanities1

Information Science7

Health Care5

Repopulation of different layers of host human Bruch's membrane by retinal pigment epithelial cell grafts. (1/1299)

Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). (2/1299)

Connective tissues: matrix composition and its relevance to physical therapy. (3/1299)

Interaction between leukocyte elastase and elastin: quantitative and catalytic analyses. (4/1299)

UVB irradiation stimulates deposition of new elastic fibers by modified epithelial cells surrounding the hair follicles and sebaceous glands in mice. (5/1299)

Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis. (6/1299)

The smooth muscle cell. III. Elastin synthesis in arterial smooth muscle cell culture. (7/1299)

Identification of a large region of secondary structure in the 3'-untranslated region of chicken elastin mRNA with implications for the regulation of mRNA stability. (8/1299)

Elastin

Tropoelastin

Desmosine

Elastic Tissue

Isodesmosine

Pancreatic Elastase

Protein-Lysine 6-Oxidase

Ligaments

Collagen

Aortic Stenosis, Supravalvular

Cutis Laxa

Aorta

Matrix Metalloproteinase 12

Williams Syndrome

Elasticity

Connective Tissue

Extracellular Matrix

Aminopropionitrile

Microfibrils

Encyclopedias as Topic

Exons

Molecular Sequence Data

Amino Acid Sequence

Protein Conformation

Dictionaries, Chemical

Agrochemicals

Dictionaries, Medical

Dictionaries as Topic

Biopharmaceutics

Pharmaceutical Preparations

Leukocyte Elastase

Foundations

Bacteriology

Nobel Prize

Ectromelia

Biotechnology

Patents as Topic

Health Facility Merger

Library Services

Archaeology

Facial Dermatoses

Galectins

Galactosides

Galectin 1

Counterfeit Drugs

Surgical Tape

Fraud

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Doping in Sports

Athletic Tape

Manufactured Materials

Cosmetics

Facility Regulation and Control

United States Food and Drug Administration

Investigational New Drug Application

Drug Industry

Repopulation of different layers of host human Bruch's membrane by retinal pigment epithelial cell grafts. (1/1299)

Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). (2/1299)

Connective tissues: matrix composition and its relevance to physical therapy. (3/1299)

Interaction between leukocyte elastase and elastin: quantitative and catalytic analyses. (4/1299)

UVB irradiation stimulates deposition of new elastic fibers by modified epithelial cells surrounding the hair follicles and sebaceous glands in mice. (5/1299)

Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis. (6/1299)

The smooth muscle cell. III. Elastin synthesis in arterial smooth muscle cell culture. (7/1299)

Identification of a large region of secondary structure in the 3'-untranslated region of chicken elastin mRNA with implications for the regulation of mRNA stability. (8/1299)

Systemic elastin degradation in chronic obstructive pulmonary disease | Thorax

Elastin fragments are pro-inflammatory in the progression of emphysema | Thorax

Neutrophil elastase and elastin-derived peptides in BAL fluid and emphysematous changes on CT scans<...

Abstract 1604: Improved Cardiac Function after Expression of the Human Elastin Gene in the Infarcted Myocardium | Circulation

The secondary structure and architecture of human elastin - Université de Reims Champagne-Ardenne

SEC Filings | Proteon Therapeutics Inc

ELASTIN | Elastin Protein Gel - COSMETIC GELS

ELASTIN | Elastin Protein Gel

ELASTIN | Elastin Protein Gel

Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction,...

The elastin receptor: a galactoside-binding protein | Science

Rapid accumulation of elastin and collagen in the aortas of sheep in the immediate perinatal period. | Circulation Research

Universidade do Minho: Elastin-like protein production kinetics at different environmental conditions in Escherichia coli

Longitudinal gradients of collagen and elastin gene expression in the porcine aorta. - Semantic Scholar

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro | Protocol

The Secrets To Increase Elastin in Skin - 3 Things You Must Know to Reclaim Youthful Skin | Ober Channel