Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
A plant genus of the family Paeoniaceae, order Dilleniales, subclass Dilleniidae, class Magnoliopsida. These perennial herbs are up to 2 m (6') tall. Leaves are alternate and are divided into three lobes, each lobe being further divided into three smaller lobes. The large flowers are symmetrical, bisexual, have 5 sepals, 5 petals (sometimes 10), and many stamens.
A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A cell line derived from cultured tumor cells.
A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.
Tetrahydroisoquinolinol alkaloids in both dextro and levo forms, originally found in SALSOLA plants.
A leukomaine (animal alkaloid) formed in brain and liver from dopamine and L-dopa; it may be implicated in psychiatric problems.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.
Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.
A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
A type of refractive surgery of the CORNEA to correct MYOPIA and ASTIGMATISM. An EXCIMER LASER is used directly on the surface of the EYE to remove some of the CORNEAL EPITHELIUM thus reshaping the anterior curvature of the cornea.
Loss of CORNEAL ENDOTHELIUM usually following intraocular surgery (e.g., cataract surgery) or due to FUCHS' ENDOTHELIAL DYSTROPHY; ANGLE-CLOSURE GLAUCOMA; IRITIS; or aging.
A surgical procedure to correct MYOPIA by CORNEAL STROMA subtraction. It involves the use of a microkeratome to make a lamellar dissection of the CORNEA creating a flap with intact CORNEAL EPITHELIUM. After the flap is lifted, the underlying midstroma is reshaped with an EXCIMER LASER and the flap is returned to its original position.
Gas lasers with excited dimers (i.e., excimers) as the active medium. The most commonly used are rare gas monohalides (e.g., argon fluoride, xenon chloride). Their principal emission wavelengths are in the ultraviolet range and depend on the monohalide used (e.g., 193 nm for ArF, 308 nm for Xe Cl). These lasers are operated in pulsed and Q-switched modes and used in photoablative decomposition involving actual removal of tissue. (UMDNS, 2005)
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
Single layer of large flattened cells covering the surface of the cornea.
A refractive error in which rays of light entering the EYE parallel to the optic axis are brought to a focus in front of the RETINA when accommodation (ACCOMMODATION, OCULAR) is relaxed. This results from an overly curved CORNEA or from the eyeball being too long from front to back. It is also called nearsightedness.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
A voluntary organization concerned with the prevention and treatment of cancer through education and research.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
"Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells". European Journal of Pharmacology. 648 (1-3): ... Cell studies[edit]. Crocin and crocetin may provide neuroprotection in rats by reducing the production of various neurotoxic ... molecules, based on an in-vitro cell study.[4] Physiological effects[edit]. A 2009 study involving 14 individuals indicated ... In high concentrations, it has protective effects against retinal damage in vitro and in vivo.[7] ...
4.2 Biological effects *4.2.1 Basal and squamous cell carcinomas. *4.2.2 Malignant melanoma ... Basal and squamous cell carcinomas[edit]. The most common forms of skin cancer in humans, basal and squamous cell carcinomas, ... Biological effects[edit]. The main public concern regarding the ozone hole has been the effects of increased surface UV ... The overall effect is a decrease in the amount of ozone, though the rate of these processes can be decreased by the effects of ...
... "bystander effect": association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in ... Gap junctions and the "bystander effect"[edit]. Cell death[edit]. The "bystander effect" with its connotations of the innocent ... "eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling". J. Cell Biol. 134 (2): ... Ripps, Harris (March 2002). "Cell death in retinitis pigmentosa: gap junctions and the 'bystander' effect". Exp. Eye Res. 74 (3 ...
... based on in vitro cultured tumor cell lines, which suggest that the effects of mTOR inhibitors may be more pronounced in ... A G0-G1 cell-cycle blockage can be the consequence of inactivation of mTOR in hypoxia-activated pericytes and endothelial cells ... That leads to late blockage of G1/S cell cycle. Rapamycin has shown to induce cancer cell death by stimulating autophagy or ... The studies of rapamycin as immunosuppressive agent enabled us to understand its mechanism of action.[5] It inhibits T-cell ...
The Philippines main export products to Mexico include: memory units; photovoltaic solar cells; harness; voltage sources; goods ... special acoustic effects generators; motor boats; control units or adapters; and modular circuits. ...
European Cells & Materials. 5: 29-30. M.H. Shamos (1965). "The Origin of Bioelectric Effects in Mineralized Tissues". Dental ... Also, clastic cells are cells that cause mineralized tissue resorption. If there is an unbalance of clastic cell, this will ... Li T.S.; Cutress T.W.; Pearce E.I. & G.E. Coote (1996). "Effects of Arsenic or/and Fluoride on Mineralized rate Tissues" (PDF ... Self-assembling films form templates that effect the nucleation of ceramic phases. The downside with this technique is its ...
Hoben GM, Koay EJ, Athanasiou KA (Feb 2008). "Fibrochondrogenesis in two embryonic stem cell lines: effects of differentiation ... specifically human embryonic stem cells. Utilization of these cells as curative cartilage replacement materials on the cellular ... The fibrocartilaginous effects of fibrochondrogenesis on chondrocytes has shown potential as a means to produce therapeutic ... These include: fibroblastic dysplasia and fibrosis of chondrocytes (cells which form cartilage); and flared, widened long bone ...
The effect of pH on the stability of polyelectrolytes is based upon the functional group on the polymer backbone that is ... For example, the ester bonds of the polyelectrolyte poly(HPMA-DMAE) can undergo hydrolysis in the human body and VERO cells ... Dong, H.; Du, H.; Wickramasinghe, S. R.; Qian, X. (2009). "The Effects of Chemical Substitution and Polymerization on the pKa ... Wang, Y.; Kimura, K.; Huang, Q.; Dubin, P. L. (1999). "Effects of Salt on Polyelectrolyte-Micelle Coacervation". Macromolecules ...
Cell. Biol. 20 (2): 583-93. doi:10.1128/MCB.20.2.583-593.2000. PMC 85138. PMID 10611237. Xiao H, Palhan V, Yang Y, Roeder RG ( ... Whitman S, Wang X, Shalaby R, Shtivelman E (2000). "Alternatively spliced products CC3 and TC3 have opposing effects on ... Cell. Biol. 24 (16): 7091-101. doi:10.1128/MCB.24.16.7091-7101.2004. PMC 479715. PMID 15282309. Suzuki Y, Yamashita R, Shirota ... Shtivelman E (Jun 1997). "A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma". Oncogene ...
December 2018). "Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors". Cell. 175 (7): 1756-1768.e17. doi:10.1530/ ... Many of the stem cells became a type of cell that matures into bone. The tissue treated with irisin produced about 40 percent ... July 2012). "Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human". Cell. 150 (2): 366-76. doi: ... In exercise related effects, PGC-1alpha induces FNDC5 gene expression through ERRα availability and that exercise leads to ...
Cell. Biol. 23 (12): 4139-49. doi:10.1128/MCB.23.12.4139-4149.2003. PMC 156123. PMID 12773558. Hillman RT, Green RE, Brenner SE ... Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K (Feb 2003). "Effect of cisplatin ... Cell. Neurosci. 18 (1): 80-90. doi:10.1006/mcne.2001.1000. PMID 11461155. S2CID 18388526. Lai MC, Lin RI, Tarn WY (2003). " ... In the cell nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, ...
The hypotensive effect of apelin results from the activation of receptors expressed at the surface of endothelial cells. This ... stomach enterochromaffine-like cells; unknown cells of endocrine pancreas, colon epithelial cells. In stomach, activation of ... This diuretic effect of apelin in association with its hypotensive effect participates in the homeostatic regulation of body ... muscle stem cells and promotes in vitro and in vivo proliferation and differentiation of these cells into mature muscle cells ...
... causes growth arrest and differentiation of promyelocytic leukemia cells". Cell. 59 (6): 959-68. doi:10.1016/0092-8674(89)90752 ... "Cytolytic effects of neutrophils: role for a membrane-bound neutral proteinase". Proceedings of the National Academy of ... American Journal of Respiratory Cell and Molecular Biology. 13 (3): 314-22. doi:10.1165/ajrcmb.13.3.7654387. PMID 7654387. ...
"Antithetic effects of MBD2a on gene regulation". Mol. Cell. Biol. 23 (8): 2645-57. doi:10.1128/MCB.23.8.2645-2657.2003. PMC ... a key activator of cell cycle-controlled histone H4 genes at the onset of S phase". Mol. Cell. Biol. 23 (22): 8110-23. doi: ... Medina R, van der Deen M, Miele-Chamberland A, Xie RL, van Wijnen AJ, Stein JL, Stein GS (2007). "The HiNF-P/p220NPAT cell ... Mitra P, Xie R, Harper JW, Stein JL, Stein GS, van Wijnen AJ (2007). "HiNF-P is a bifunctional regulator of cell cycle ...
Danzo BJ (November 1998). "The effects of environmental hormones on reproduction". Cell. Mol. Life Sci. 54 (11): 1249-64. doi: ... Effects on Cell Functions". Environmental Health Perspectives. 121 (3): 352-8. doi:10.1289/ehp.1205826. PMC 3621186. PMID ... as is the role of an estrogenic effect compared to some other toxic effect of bisphenol A. Other scientists argue that the ... Another potential effect of xenoestrogens is on oncogenes, specifically in relation to breast cancer. Some scientists doubt ...
Badal S, Her YF, Maher LJ (September 2015). "Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells". The Journal of ... Adult stem cells like bone marrow stem cells have also shown a potential to differentiate into cardiac competent cells when ... In mammals, most cells terminally differentiate, with only stem cells retaining the ability to differentiate into several cell ... cells: how cells can change fate" (PDF). Trends in Cell Biology. 17 (3): 101-6. doi:10.1016/j.tcb.2006.12.005. PMID 17194589. ...
The effect of TEs in the genome is not entirely selfish. Because their insertion into the genome can disrupt gene function, ... doi:10.1016/j.cell.2008.09.037. PMC 2703716. PMID 19013280. Queller DC, Ponte E, Bozzaro S, Strassmann JE (January 2003). " ... One example is the lethality of the t-haplotype in mice, another is the effect on male fertility of the Sex Ratio system in D. ... Following Dawkins, a greenbeard is usually defined as a gene, or set of closely linked genes, that has three effects: It gives ...
Cell. 169 (7): 1177-1186. doi:10.1016/j.cell.2017.05.038. PMC 5536862. PMID 28622505. Brown, Kristen V. (2017-06-16). "This ... Liu, Xuanyao; Li, Yang I.; Pritchard, Jonathan K. (May 2019). "Trans Effects on Gene Expression Can Drive Omnigenic Inheritance ... in a 2017 paper in Cell. According to this model, a small number of "core genes" with biological relevance to a given trait, as ... doi:10.1016/j.cell.2019.04.014. PMC 6553491. PMID 31051098. v t e. ...
These effects have also been seen in the F3 generation depending on the length of protein restriction. If protein restriction ... Cell. Biol. 23 (15): 5293-5300. doi:10.1128/MCB.23.15.5293-5300.2003. PMC 165709. PMID 12861015. Sziv KS, Ndlovu MN, Haegeman G ... Additional studies have investigated the effect of a PR-diet in rats and found changes in promoter methylation of both the ... Additionally, rats fed diets lacking or including methyl donors are often used to study the effects of diet on epigenomics, as ...
doi:10.1016/j.cell.2006.07.014. PMID 16901780. S2CID 15985536. "Bottlenecks and founder effects". Understanding Evolution. ... When there are few copies of an allele, the effect of genetic drift is larger, and when there are many copies the effect is ... With a higher recombination rate, linkage decreases and with it this local effect on effective population size. This effect is ... for the effects of drift to be substantial and thought drift would have an insignificant effect on the evolutionary process. ...
"Estrogen receptor subtype-specific effects on markers of bone homeostasis" (PDF). Mol. Cell. Endocrinol. 291 (1-2): 104-8. doi: ... In contrast to testosterone however, 8β-VE2 shows no androgenic effects. The effects of 8β-VE2 and ERβ may be mediated, in part ... In contrast, 16α-LE2 stimulates uterine weight, whereas 8β-VE2 has no effect, indicating that the ERα and not the ERβ is ... Moreover, similarly to testosterone, 8β-VE2 has anabolic effects in skeletal muscle and significantly increases muscle mass as ...
"Estrogen receptor subtype-specific effects on markers of bone homeostasis". Mol. Cell. Endocrinol. 291 (1-2): 104-8. doi: ... In contrast, 16α-LE2 stimulates uterine weight, whereas 8β-VE2 has no effect, indicating that the ERα and not the ERβ is ... In rodents, 16α-LE2 has no effect on ovarian follicle development, whereas the highly ERβ-selective agonist 8β-VE2 stimulates ... protective effects of estrogens on bone formation resorption and bone mineral density are mediated via the ERα, whereas the ERβ ...
... in Drosophila cells and is present in native Drosophila tissue culture cells, unlike clk, per, or tim. Regulation thus occurs ... This effect, however, did display gender dimorphism, as female Drosophila showed no significant shortening in life span even ... In the cell nucleus, the CYCLE protein (CYC) forms a heterodimer with a second bHLH-PAS protein, CLOCK (CLK). This CYC-CLK ... They published the papers reporting the discovery of CYCLE and CLOCK in the same issue of Cell. They found both genes as a ...
"Wellcome Centre for Cell Biology - Wellcome Centre for Cell Biology". University of Edinburgh. "Wellcome Trust lab". The Irish ... Allshire, R. C; Javerzat, J. P; Redhead, N. J; Cranston, G (1994). "Position effect variegation at fission yeast centromeres". ... Cell. 137 (7): 1173-4. doi:10.1016/j.cell.2009.06.010. PMC 4397584. PMID 19563746. Subramanian, L; Toda, N. R. T; Rappsilber, J ... Cell. 140 (5): 666-77. doi:10.1016/j.cell.2010.01.038. PMC 2875855. PMID 20211136. Buscaino, Alessia; White, Sharon A; Houston ...
Secretory cells Staining Target Effect Adrenocorticotropic hormone Corticotropin ACTH Polypeptide Corticotrophs Basophil ... The pars distalis contains two types of cells including chromophobe cells and chromophil cells.[1] The chromophils can be ... further divided into acidophils (alpha cells) and basophils (beta cells).[1] These cells all together produce hormones of the ... Effects of the anterior pituitary[edit]. Thermal homeostasis. The homeostatic maintenance of the anterior pituitary is crucial ...
... analogy to apoptosis of somatic cells". Experimental Cell Research. 207 (1): 202-5. doi:10.1006/excr.1993.1182. PMID 8391465. ... Robbins WA, Elashoff DA, Xun L, Jia J, Li N, Wu G, Wei F (2005). "Effect of lifestyle exposures on sperm aneuploidy". ... Cell. Endocrinol. 315 (1-2): 49-56. doi:10.1016/j.mce.2009.08.004. PMC 3516447. PMID 19682538. Fody EP, Walker EM (1985). " ... "Researchers made Sperm Cells from Skin of infertile men". Retrieved 2014-05-08. Press Association (17 August 2017). "New sperm ...
Cell. 143 (3): 404-15. doi:10.1016/j.cell.2010.09.041. PMID 20970175. S2CID 18583237. PDB: 3NK3​ PDB: 3NK4​ Jovine L, Qi H, ... 2008). "Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human ... Cell. 143 (3): 404-15. doi:10.1016/j.cell.2010.09.041. PMID 20970175. S2CID 18583237. PDB: 3NK3, 3NK4​ Bansal P, Chakrabarti K ... Cell Biol. 3 (2): E59-64. doi:10.1038/35055178. PMID 11175768. S2CID 6172791. Zhao M, Boja ES, Hoodbhoy T, et al. (2004). "Mass ...
Song IH, Buttgereit F (2006). "Non-genomic glucocorticoid effects to provide the basis for new drug developments". Mol. Cell. ... Unlike the classical nuclear glucocorticoid receptor (GR), which mediates its effects via genomic mechanisms, mGRs are cell ... Cell. Endocrinol. 350 (2): 299-309. doi:10.1016/j.mce.2011.06.020. PMID 21736918. Löwenberg M, Verhaar AP, van den Brink GR, ... Groeneweg FL, Karst H, de Kloet ER, Joëls M (2011). "Rapid non-genomic effects of corticosteroids and their role in the central ...
"A stable prostatic bioluminescent cell line to investigate androgen and antiandrogen effects". Mol. Cell. Endocrinol. 160 (1-2 ... The effect of a topical antiandrogen: results of a multicenter clinical trial". Archives of Dermatology. 128 (9): 1197-1200. ...
The nicotine from cigarettes makes people want to smoke more, even if they do not like the taste or its other effects. The ... Tar is a sticky substance that kills cells and causes lung cancer. ...
Photoelectric cells in a spectrophotometer device worn on the forehead measure the amount of each wavelength of light reflected ... Sherrill, R. (2004). Effects of hemoencephalographic (HEG) training at three prefrontal locations upon EEG ratios at Cz. ... and cause and effect determination. The prefrontal cortex is thought essential for all goal-directed and socially-mediated ...
This growth pattern exerts an effect at the base of the skull, which is not even when the child is assessed from a point of ... Certain cells in the brain respond specifically to an increase of CO2 in the blood.[4][24] The response involves vasodilatation ... Bristol RE, Lekovic GP, Rekate HL (December 2004). "The effects of craniosynostosis on the brain with respect to intracranial ... likely through effects on fibroblast growth factor receptor genes.[28][29][30][31][32] ...
cell nucleus. Biological process. • anterior/posterior pattern specification. • multicellular organism development. • anterior/ ... In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.[7] ... Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551-3. doi:10.1016/0092-8674(92)90588-4. PMID ... and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation". Tumour Biol. ...
If the stem cells and sebaceous gland are destroyed, there is then no possibility for regeneration of the hair follicle, and ... You should discuss any treatment with your dermatologist, who will also explain potential side effects, as well as laboratory ... The goal of treatment is to decrease or eliminate the lymphocytic inflammatory cells that are attacking and destroying the hair ... However, all cicatricial alopecias involve inflammation directed at the upper part of the hair follicle where the stem cells ...
... a type 2 diabetic will have lost about half of their beta cells.[52] Fatty acids in the beta cells activate FOXO1, resulting in ... and these effects are evident even without weight loss.[93] Aerobic exercise leads to a decrease in HbA1c and improved insulin ... Type 2 diabetes is due to insufficient insulin production from beta cells in the setting of insulin resistance.[13] Insulin ... In the early stages of insulin resistance, the mass of beta cells expands, increasing the output of insulin to compensate for ...
Eric Dubois et al.: Effect of pollen traps on the relapse of chronic bee paralysis virus in honeybee (Apis mellifera) colonies ... Santeuil and Le Blanc viruses primarily infect intestinal cells in Caenorhabditis nematodes, in: Virology, Volume 448, 5. ...
The removal of trees in infected areas has little effect as the fungus lives and grows on leaf litter on the forest floor.[10] ... perforating the middle lamella but damage to either the plasmalemma or cell walls was not observed.[29] The disease is often ...
Hamming codes are only suitable for more reliable single-level cell (SLC) NAND. Denser multi-level cell (MLC) NAND requires ... This all-or-nothing tendency - the cliff effect - becomes more pronounced as stronger codes are used that more closely approach ... Because of this "risk-pooling" effect, digital communication systems that use ECC tend to work well above a certain minimum ... "Error Correction Code in Single Level Cell NAND Flash memories" 16 February 2007 ...
Degen, L. "Effect of peptide YY3-36 on food intake in humans". Gastroenterology. 129: 1430-6. doi:10.1053/j.gastro.2005.09.001 ... The brain detects insulin in the blood, which indicates that nutrients are being absorbed by cells and a person is getting full ... McKenna, R. J. (1972). "Some Effects of Anxiety Level and Food Cues on the Eating Behavior of Obese and Normal Subjects: A ... When the glucose levels of cells drop (glucoprivation), the body starts to produce the feeling of hunger. The body also ...
Side effects[edit]. The most common side effects of indinavir include: *Gastrointestinal disturbances (abdominal pain, diarrhea ... 1156 patients with a mean of 87 CD4 cell counts and mean viral load of 100,000 copies/ml were randomized to one of the two ... Viral resistance to the drug leads to the drug becoming useless since the virus evolves to have cells that are able to resist ... There were higher CD4 cell counts and less viral load in patients assigned to the three-drug group, proving that a three-drug ...
Cells are homogenised in a blender and filtered to remove debris. *The homogenised sample is placed in an ultracentrifuge and ... which would exert a much greater centrifugal effect.[11] In addition, he developed the theory necessary to measure molecular ... General method of fractionation: Cell sample is stored in a suspension which is: *Buffered - neutral pH, preventing damage to ... This method is commonly used to separate organelles and membranes found in cells. Organelles generally differ from each other ...
Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins ( ... Effects of inducers of monooxygenase on the kinetic constants of prostaglandin hydroxylation". J. Biol. Chem. 256: 2168-2175. ... Kupfer, D., Miranda, G.K., Navarro, J., Piccolo, D.E. and Theoharides, A.D. (1979). "Effect of inducers and inhibitors of ... Nebert, D.W. and Gelboin, H.V. (1968). "Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and ...
ElSawy, N. A.; Hadda, T. B.; Bakr, E. H.; Header, E.A.M.; Fakim, A. G.; Mabkhot, Y. N.; Aljofan, M.. Effects of Crude Aqueous ... In vitro modulation of oxidative burst via release of reactive oxygen species from immune cells by extracts of selected ... Mahomoodally, M. F.; Gurib-Fakim, A.; Subratty, A. H.. «Effect of exogenous ATP on Momordica charantia Linn. (Cucurbitaceae) ... Mahomoodally, M. F; Gurib Fakim, A.; Subratty, A. H.. «Stimulatory effects of Antidesma madagascariense on D-glucose, L- ...
The cells met to read Marxist texts and hold self-criticism sessions.[51] Sâr joined a cell that met on the rue Lacepède; his ... An estimated 300,000 Cambodians starved to death between 1979 and 1980, largely as a result of the after-effects of Khmer Rouge ... They established party cells, emphasising the recruitment of small numbers of dedicated members, and organized political ... he believed that peasants could develop a proletarian consciousness as an effect of the communist party's education of the ...
Sertoli cell proliferation. • توصيل الإشارة. • peptide hormone processing. • positive regulation of gene expression. • cell- ... modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle". Regul. Pept. 81 (1-3): 67-71. PMID 10395410. doi ... positive regulation of cell migration. • positive regulation of transcription from RNA polymerase II promoter. • حمل أنثوي. • ... 1989). "Expression of biologically active human follitropin in Chinese hamster ovary cells". J. Biol. Chem. 264 (9): 4769-75. ...
In a similar effect, patients with a broken leg joint undergoing as little as three weeks of traction can lose enough back and ... "satellite cells" which help to regenerate skeletal muscle fibers, and a decrease in sensitivity to or the availability of ... Wu H, Xia Y, Jiang J, Du H, Guo X, Liu X, Li C, Huang G, Niu K (September 2015). "Effect of beta-hydroxy-beta-methylbutyrate ... More research is needed to determine the precise effects of HMB on muscle strength and function in this age group. Since the ...
Invasins, such as pneumolysin, an antiphagocytic capsule, various adhesins, and immunogenic cell wall components are all major ... pneumoniae against the bactericidal effect of mitomycin C.[17] Michod et al.[18] summarized evidence that induction of ... and white blood cells to fill the alveoli. This condition is called pneumonia.[20] It is susceptible to clindamycin.[21] ... "Inhibitory and Bactericidal Effects of Hydrogen Peroxide Production by Streptococcus pneumoniae on Other Inhabitants of the ...
Effect of fluctuations[edit]. When the dielectric constant ϵ. {\displaystyle \epsilon }. of a certain region of volume V. {\ ... The moonlit sky is not perceived as blue, however, because at low light levels human vision comes mainly from rod cells that do ... The effect is further increased because the sunlight must pass through a greater proportion of the atmosphere nearer the ... In 1871, Lord Rayleigh published two papers on the color and polarization of skylight to quantify Tyndall's effect in water ...
B. C. Giovanella u. a.: Development of invasive tumors in the nude mouse after injection of cultured human melanoma cells. In: ... C. O. Povlsen, J. Rygaard: Effects of Cyclophosphamide (Endoxan R) on a Burkitt´s Lymphoma serially grown in nude mice. In: ... L. Miers u. a.: Implantation of different malignant human cell lines in an athymic mouse does not alter success and growth ... T. Devos u. a.: Occurrence of autoimmunity after xenothymus transplantation in T-cell-deficient mice depends on the thymus ...
However, lawrencium is an exception, since its last electron is transferred to the 7p1/2 subshell due to relativistic effects.[ ... The element is known to damage cell membranes of water animals, causing several negative influences on reproduction and on the ... The high radioactivity of lawrencium would make it highly toxic to living cells, causing radiation poisoning. The same is true ... The radioactivity of the actinides generally makes them highly toxic to living cells, causing radiation poisoning. ...
This tracer is a glucose analog that is taken up by glucose-using cells and phosphorylated by hexokinase (whose mitochondrial ... A further advantage of statistical image reconstruction techniques is that the physical effects that would need to be pre- ... This means that FDG is trapped in any cell that takes it up until it decays, since phosphorylated sugars, due to their ionic ... Effects of inaccurate attenuation correction". Journal of Computer Assisted Tomography. 3 (6): 804-814. doi:10.1097/00004728- ...
The TH2 lymphocytes interact with B cells and together they produce IgE. IgE circulates around and binds to receptors of cells ... drug sensitization or reverse tolerance - the escalating effect of a drug resulting from repeated administration at a given ... Drug sensitization occurs in drug addiction, and is defined as an increased effect of drug following repeated doses (the ... tolerance - the diminishing effect of a drug resulting from repeated administration at a given dose ...
Films in annular ring mounts on gas-tight cells, will readily deform into spherical mirrors. Photomultiplier cosmic-ray ... In nail polish, as a coloured and finely shredded additive to create a glitter effect. ... it is not immune to the effects of fire and heat and could potentially melt, depending on the intensity of the heat source, ...
... epidermal hair cells (trichomes), cells in the stomatal complex; guard cells and subsidiary cells. The epidermal cells are the ... Waxy micro- and nanostructures on the surface reduce wetting by rain and adhesion of contamination (See Lotus effect). ... Cells that bring water and minerals from the roots into the leaf.. Phloem. Cells that usually move sap, with dissolved sucrose( ... Its cells contain many more chloroplasts than the spongy layer. Cylindrical cells, with the chloroplasts close to the walls of ...
... dendritic cells and other cells including liver cells, fibroblasts, and adrenal gland cells.[93] Viral replication triggers ... See also: Cultural effects of the Ebola crisis. Weaponisation. Ebolavirus is classified as a biosafety level 4 agent, as well ... doi:10.1016/j.cell.2014.10.006. PMC 4243531. PMID 25417101.. *^ a b c d e f g h Kühl A, Pöhlmann S (September 2012). "How Ebola ... liver cells, and several types of immune cells such as macrophages, monocytes, and dendritic cells are the main targets of ...
... excess secretion from the acidophil cells) caused acromegaly, then an excess of basophil cells must be involved in another ... In addition to the severe hormonal effects related to increased blood cortisol levels, the large tumor can compress adjacent ... Given this conviction, and his knowledge of the three anterior pituitary cell types, Cushing hypothesized that if acidophil ... In a patient with Cushing's disease, the tumor cells will be stimulated to release corticotropin and elevated plasma ...
It also contains pacemaker cells and nonpacemaker cells that initiate spontaneous breathing. Research is being conducted on the ... The activation of different calcium channels has distinct effects on the activity of neurons in the pre-Bötzinger complex. L- ... It is one of the four cell groups of the Ventral Respiratory Group (VRG). It is hypothesized that the pre-Bötzinger complex is ... which helps cell regenerate its bursts. The ratio between inward and outward currents helps determine the activity of pacemaker ...
Cornelius AS, Yerram NR, Kratz DA, Spector AA: Cytotoxic effect of cis-parinaric acid in cultured malignant cells. Cancer Res. ...
Effects[edit]. After Medicaid was enacted, some states repealed their filial responsibility laws, but most states still require ... T-cell count drops below 200).[76] The Medicaid eligibility policy contrasts with the Journal of the American Medical ... "Oregon Study: Medicaid 'Had No Significant Effect' On Health Outcomes vs. Being Uninsured". Forbes. Retrieved April 18, 2019.. ... These payments will be in effect through 2016, phasing down to a permanent 90 percent matching rate by 2020.. Centers for ...
The effect was clear: the cancer cells were wasting away, but only those on the side that got the neurotoxin. ... "The effect on survival was the greatest Ive ever seen," says Elizabeth Repasky at the Roswell Park Cancer Institute in Buffalo ... So could this effect extend to humans? Although certain cancers show little infiltration by nerves - thyroid cancer, for ... It stopped the cancer dead in its tracks - and surgically nicking the nerves had the same effect. "We didnt expect any of that ...
Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune ... Antiinflammatory effects of apoptotic cells J Clin Invest. 2013 Jul;123(7):2773-4. doi: 10.1172/JCI69344. Epub 2013 Jul 1. ... Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune ... 1 Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA. [email protected] ...
Antiinflammatory effects of apoptotic cells. Peter M. Henson and Donna L. Bratton Program in Cell Biology, Departments of ... Responses of macrophages to recognition of apoptotic cells. (A) The antiinflammatory effects outlined in the 1998 JCI paper (7 ... Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR, Girkontaite I. Immunosuppressive effects of apoptotic cells. Nature. 1997;390 ... Further, while TGF-β seems to be an important mediator of the response to apoptotic cell recognition, the effects on ...
Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune ... and colleagues at National Jewish Health demonstrated that phagocytosis of apoptotic cells actively suppresses inflammation by ...
What happens when a cell is exposed to a harmful substance? The reactions that occur are often very specific and provide an ... Effects on cells. What happens when a cell is exposed to a harmful substance? The reactions that occur are often very specific ... In the laboratory, we use human cells or artificial tissues to make refined, accurate measurements of the effects on specific ... More about effects of substances on humans and animals. *Absorption and digestion ...
... eventually defining a candidate drug that has little effect on normal stem cells but kills the cells that start the tumor," ... The anti-psychotic drug, thioridazine, showed to have no effect on normal stem cells in the study. In the past, thioridazine ... With thioridazine, leukemia cells were eliminated but without affecting normal blood stem cells. The researchers were better ... While leukemia cells express a dopamine receptor on their surfaces, normal stem cells do not. ...
Cytopathologic effects of chlorhexidine on human cells.. Goldschmidt P, Cogen R, Taubman S. ... Cytopathologic[Title] AND effects[Title] AND chlorhexidine[Title] AND human[Title] AND cells[Title]. Search. ... Search: Cytopathologic[Title] AND effects[Title] AND chlorhexidine[Title] AND human[Title] AND cells[Title] ... Exposure of cells to 0.2% chlorhexidine for 30 seconds produced maximal suppression of protein synthesis and release of 51Cr. ...
Effect of trypsin and zymosan on the respiration of cultivated endothelial cells. Pharmazie 46:46-48.Google Scholar ... Cytotoxic effects estimated by cell counting after 72 h treatment with salsolinol (IC50=38 μmol/l) were possibly caused by ... Because endothelial cells are an important element of this barrier the present study was designed to assess the influence of ... Salsolinol toxicity endothelial cells respiration mitochondria ultrastructure This is a preview of subscription content, log in ...
... Aleksandra Vasic,1 Predrag Osmokrovic,2 Nenad Marjanovic,3 and ... The effects of ionizing radiation may cause changes in stored data, or even the physical destruction of the components. The ... Radiation effects in insulating films were also investigated. In L. Timotijevic et al.s paper Monte Carlo simulation of proton ... The effect of direct ionizing radiation on semiconductor memory behavior has been analyzed by using Monte Carlo simulation ...
Cell Viability Analysis. Cells were plated in 96-well plates (. cells/well). 24 hours later, cells were exposed to increasing ... Antitumor Effects of Wogonin on A2780 Ovarian Cancer Cells. We first examined effects of wogonin on cell proliferation of A2780 ... Figure 4: Effects of wogonin on cell cycling distribution of A2780 ovarian cancer cells. (a) Representative results of the flow ... We determined the effects of wogonin on the changes of cell cycling and apoptotic responses of cells. Western blot analysis was ...
5G networks will require many more cell sites, operating at higher frequencies. ... Do transmissions to and from 5G cells, which will need to be everywhere, and much closer to us than traditional cell towers, ... But I am learning that some scientists believe that the intensity of 5G represents a change and that 5Gs effects on humankind ... But what if the FCC is measuring public health effects against a decades-old standard that measures the wrong thing? I think ...
5G networks will require many more cell sites, operating at higher frequencies. ... 5G and the Health Effects of Cell Phones. The FCCs safety standards for cellular communications date from 1996. 5G networks ... Do transmissions to and from 5G cells, which will need to be everywhere, and much closer to us than traditional cell towers, ... But I am learning that some scientists believe that the intensity of 5G represents a change and that 5Gs effects on humankind ...
San Francisco scientists working in the lab used a chemical found in an anti-wrinkle cream to prevent the death of nerve cells ... Effects of Parkinsons-Disease Mutation Reversed In Cells 44 Posted by Soulskill on Saturday August 17, 2013 @10:03PM. from the ... Submission: Effects of Parkinsons-Disease Mutation Reversed in Cells. Mozilla Planning Firefox Metro For Windows 8 On December ... Effects of Parkinsons-Disease Mutation Reversed In Cells. Archived Discussion. Load All Comments ...
Learn more about treating cancer with CAR T-cell therapy here. ... that are altered in the lab so they will attack cancer cells. ... Some cancers can be treated with immune cells called T cells ... Possible CAR T-cell therapy side effects. CAR T-cell therapy ... Chimeric antigen receptor (CAR) T-cell therapy is a way to get immune cells called T cells (a type of white blood cell) to ... Other serious side effects: Other possible serious side effects of CAR T-cell therapy can include:. *Allergic reactions during ...
... and its a rare cancer patient who escapes debilitating side effects from systemic treatments that mostly affect dividing cells ... Eliminating the senescent cells in mice prevented the side effects and relapse. The research is published in Cancer Discovery. ... Chemotherapy-induced senescent cells promote side effects and cancer relapse. *Download PDF Copy ... Results showed that eliminating chemotherapy-induced senescent cells reduced several short-and long-term effects of treatment, ...
Here, we explored the effects of hispolon on human glioblastoma cells U87MG. Cell viability was examined by MTT assay. Growth ... Moreover, hispolon treatment was effective on U87MG cells in inhibiting cell viability and inducing cell apoptosis. Our results ... Effects of hispolon on glioblastoma cell growth.. Arcella A1, Oliva MA1, Sanchez M2, Staffieri S1, Esposito V1,3, Giangaspero F ... 48 or 72 h and daily cell count. Cell cycle and apoptosis assay were assessed by flow cytometry. Hispolon decreased cell ...
When cancer cells are under regular culture condition, they show Warburg effect; whereas under lactic acidosis, they show a ... These two metabolic modes are intimately interrelated, for Warburg effect generates lactic acidosis that promotes a transition ... This dual metabolic nature confers growth advantage to cancer cells adapting to ever changing microenvironment. ... Warburg effect is a dominant phenotype of most cancer cells. Here we show that this phenotype depends on its environment. ...
Our results show that EV71 proliferates in the neural cells and leads to neural cell lesions. The study of the pathology of ... Cao, X. , Wang, L. , Liu, L. , Liao, Y. , Dong, C. and Li, Q. (2010) Biological effects of EV71 infection in neural cells. ... Our results show that EV71 proliferates in the neural cells and leads to neural cell lesions. The study of the pathology of ... 2009) Detection of five different cells sensitivities to enterovirus 71 using plaque forming assay World Journal of ...
Cocaine can alter individual brain cells and entire regions of the brain. Stopping may help your brain recover, but some ... Using cocaine does kill brain cells over time. ... long-term effects of using cocaine. Cocaine can have long-term ... Cocaine, whether in powder or crack form, has a powerful effect on the body and the brain. Using cocaine can damage brain cells ... Most short-term side effects of cocaine wear off within a day or two. But long term side-effects can be permanent. ...
New study: An NIH study of cell phones and the brain showed definite effects on the brain and nervous system from cell phone ... Cell Towers: Wireless Convenience or Environmental Hazard (includes studies about cell tower radiation and biological effects) ... Threat of harmful effects on human health and public safety from proposed Beebe Cell Tower: statement to Connecticut Siting ... Are there studies finding adverse health effects, including cancer, in those living near cell towers (mobile phone base ...
The effect of exposure to silica inhalation on two cytochrome-P450 dependent enzymes (ethoxycoumarin-deethylase and ... Exposure to silica had no statistically significant effect on the induction ... NIOSH-Author; Lung-cells; Cell-function; Cell-damage; Silica-dusts; Inhalation-studies; Laboratory-animals; Pulmonary-function ... deethylase activity in whole cells but not in microsomal or sonicated whole cell preparations. The effect of PAF may be ...
In this study, we evaluated the antiproliferative effects of appl … ... Antiproliferative effects of apple peel extract against cancer cells Nutr Cancer. 2010;62(4):517-24. doi: 10.1080/ ... In this study, we evaluated the antiproliferative effects of apple peel extract (APE) in variety of cancer cell types. Our data ... Our data suggested that APE possesses strong antiproliferative effects against cancer cells, and apple peels should not be ...
... to provide a cell culture model of essential fatty acid deficiency (EFAD).... ... epithelial cells were grown in culture medium supplemented with 1% fetal bovine serum (FBS) ... Gerschenson, L.E., Harary, I., and Mead, J.F. (1967) Studiesin vitro on Single Beating Rat-Heart Cells. X. The Effect of ... Functional and ultrastructural effects of essential fatty acid deficiency in kidney epithelial cells. ...
Laser Surgery Does Not Appear To Have Long-Term Effects On Corneal Cells. by Sam Savage ... Photographs of the cells lining the cornea (endothelial cells) were taken and analyzed before and nine years after surgery. The ... However, the average annual rate of cell loss (0.6 percent) was the same in corneas of eyes that were operated on and those ... Laser eye surgery to correct vision problems does not appear to be associated with lasting changes to cells lining the inside ...
MadSci Network: Cell Biology Query: Re: Which rapidly dividing cells can show the effects of ionizing radiation?. Date: Mon Sep ... Cell Biology archives Try the links in the MadSci Library for more information on Cell Biology. MadSci Home , Information , ... observe/demonstrate the cell killing in mammalian cells. Some mutant cell lines, such as AT1BR with ATM and other repair ... Area of science: Cell Biology. ID: 1284083287.Cb Message:. The thumb rule that "rapid dividing cells are more sensitive" apply ...
In microgravity, many types of cells grow as a cluster of round cells rather than a sheet of flat cells as on earth. In an ... In space, growing cells like to form clusters of spherical cells. To understand why, scientists grew human thyroid cancer cells ... Single cancer cells of the FTC-133 cell line are cultured during NanoRacks-CellBox-Thyroid Cancer) investigation. The cells are ... Certain cell receptors and cell signaling mechanisms work differently in space, which affects how cancer cells grow. ...
Fatigue, nausea, skin changes, and weakness are just a few of the side effects you may experience while on one of these ... Here are 12 tips to help you feel better if youre experiencing side effects from your cancer treatment. ... There are many treatments available for advanced cutaneous squamous cell carcinoma. ... 12 Tips for Managing Side Effects of Advanced Cutaneous Squamous Cell Carcinoma Treatments. Medically reviewed by Yamini ...
Learn about the side effects of stem cell transplant, such as infection, bleeding and graft-versus-host disease, and how side ... the donors T cells may be removed from the stem cells. This is called T-cell depletion. T cells are a type of white blood cell ... A stem cell transplant is a very complex procedure. Side effects of stem cell transplant can be very serious or even life- ... Side effects of stem cell transplant. Side effects can happen with any type of treatment, but everyones experience is ...
Stem cells may provide Crohns disease sufferers relief from a common, potentially dangerous side effect - fistulas - ... Stem cells may provide Crohns disease sufferers relief from a common, potentially dangerous side effect - fistulas - according ... Stem cells may provide Crohns disease sufferers relief from a common, potentially dangerous side effect - fistulas - according ... Trial Shows Stem Cells Provide Long-Term Relief from Dangerous Crohns Side Effect. ...
The study looked at the effects of moringa on esophageal cancer, a type of cancer diagnosed in many members of South Africas ... Measuring cancer cell "fitness" reveals drug susceptibility. By studying both the physical and genomic features of cancer cells ... Their new approach, which combines measurements of cell mass and growth rate with analysis of a cells gene expression, could ... Love Effect 2018 South Indian Movies Dubbed In Hindi Full Movie , Ram Charan, Neha Sharma, Prakash. *published: 09 Sep 2018 ...
  • The dualism between apoptosis and necrosis and their effects is now generally recognized, although both terms were originally coined in the context of tissue pathology. (
  • Wogonin is a plant monoflavonoid and has been reported to induce apoptosis of cancer cells and show inhibitory effect on cancer cell growth. (
  • In addition, exposure to wogonin increased caspase-3 cleavage and induced apoptosis in A2780 cells. (
  • Cell cycle and apoptosis assay were assessed by flow cytometry. (
  • Moreover, hispolon treatment was effective on U87MG cells in inhibiting cell viability and inducing cell apoptosis. (
  • Our results indicate that hispolon inhibits the cell viability, induces G2/M cell cycle arrest and apoptosis in glioblastoma U87MG cells, and p53 should play a role in hispolon-mediated antitumor activity. (
  • In this work, we expand on our previous work with DEHP and screen the 2-EH metabolite for different cell death endpoints such as growth inhibition, apoptosis, autophagy, caspase activation, DNA fragmentation, and cell cycle arrest using fluorophores and the NC3000 instrument. (
  • Also, 2-EH presented apoptosis induction with characteristic hallmarks, such as loss of mitochondrial membrane potential, caspase activation, DNA fragmentation and cell cycle arrest at the S phase. (
  • Our previous work [10] established the toxicity and apoptosis induction of both DEHP and MEHP on human lymphoblast cells. (
  • Apoptosis was investigated by measuring caspase-3 activity and by evaluating nuclear morphology of cells stained with Hoechst 33342. (
  • Effects on proliferation and/or dysregulation of apoptosis in lens epithelial cells may be an important factor in human steroid-induced posterior subcapsular cataract. (
  • The remedies exerted preferential cytotoxic effects against the two breast cancer cell lines, causing cell cycle delay/arrest and apoptosis. (
  • Previous studies in cultured neurons and in the intact brains of rodents provided evidence suggesting that exposure to anesthetics might render neurons more susceptible to cell death through a process called 'apoptosis'," said Halpain. (
  • In general, the mRNA levels of genes involved in cytoprotection were upregulated, wheras a number of genes related to inflammation, apoptosis and tumor suppression were downregulated in cultured PC3 cells treated with TNF-α and extract of coffee as compared to controls treated with TNF-α only. (
  • In xenograft of PC3 cells, genes related to inflammation, apoptosis, cytoprotection and cell proliferation and differentiation were downregulated in mice fed a coffee containing diet. (
  • In TNF- stimulated PC3 cells, genes related to inflammation and tumor suppression were downregulated by tomato extract, whereas genes related to apoptosis and cancer were upregulated. (
  • Our results showed that treatment with wogonin inhibited the cancer cell proliferation, decreased the percentage of G0/G1 subpopulation, and reduced invasiveness of A2780 cells. (
  • ER- α mediates both genomic signaling pathways and nongenomic signaling pathways, regulating cancer cell proliferation [ 6 , 7 ]. (
  • In her study, Jone Michelena has already identified such a combination, which inhibits cancer cell proliferation to a significantly higher extent than the combination's individual components by themselves. (
  • Furthermore, APE treatment resulted in a marked concentration-dependent decrease in the protein levels of proliferative cell nuclear antigen, a marker for proliferation. (
  • Herein, we examined the effects of cyclosporin A, a commonly used immunosuppressive molecule, on NPC proliferation kinetics, survival, and fate using in vitro assays at the population level and at the single-cell level. (
  • The use of pure populations of NPCs revealed a direct effect of cyclosporin A on cell survival, resulting in increased numbers and larger colonies, with no effect on proliferation kinetics. (
  • Here, we have reviewed the current data about the influence of NB-UVB on epidermal cells, with a special emphasis on cell proliferation and death. (
  • 2006 ), treatment of animals with cell proliferation inhibitors at the time of an epileptogenic brain injury reduced the frequency of later spontaneous seizures. (
  • The number of viable cells was determined using the 3-[4, 5-dimethylthiazolyl-2]-2, 5-diphenyltetrazolium bromide (MTT) assay, and proliferation was quantified using Ki-67. (
  • Tested hybrid compounds differentially influenced proliferation of non-stimulated and LPS-stimulated RAW 264.7 cells. (
  • As ovulation in rodents requires an increased formation of PGE2 and has been shown to be antedated by proliferation of thecal fibroblasts, we determined the ability of NGF to affect these parameters in trkA-transfected thecal cells. (
  • Induction of ovulation in immature rats by gonadotropin treatment verified that an increased cell proliferation in the thecal compartment, determined by the incorporation of bromodeoxyuridine into cell nuclei, occurs 4-5 h before ovulation in this species. (
  • In fact the in vitro strategy developed to demonstrate the effects of oestrogen has several advantages over the current standard animal experiments. (
  • Together, our findings establish that cyclosporin A has direct effects on NPCs both in vitro and in vivo , making it a promising candidate molecule for developing clinically relevant strategies to stimulate NPCs for brain repair. (
  • They can be isolated in vitro in the presence of growth factors, whereby single cells proliferate to form free-floating colonies termed "neurospheres" ( Reynolds and Weiss, 1992 ). (
  • Herein, we use in vitro and in vivo assays to examine the effects of cyclosporin A on NPC behavior. (
  • In vitro effects of benzene metabolites on mouse bone marrow stromal cells. (
  • The effects of benzene (71432) metabolites on bone marrow stromal cells were investigated in-vitro. (
  • The authors conclude that benzene metabolites are toxic to mouse bone marrow stromal cells in-vitro. (
  • To gain insight into the radiobiology underlying IMRT and help radiation oncologists reap the maximum benefit from this advanced technique, an Australian research collaboration has performed a series of in vitro experiments examining cell survival following exposure to spatially modulated beams ( Physics in Medicine and Biology , September 21, 2007, Vol. 52:18, pp. 5469-5482). (
  • This work examines the effect of Qigong from two experienced practitioners on in vitro cellfree myosin phosphorylation. (
  • Furthermore, quercetin abrogated the ability of LPS-stimulated DCs to induce Ag-specific T cell activation, both in vitro and in vivo. (
  • Using human RPE-derived ARPE-19 cells as an in vitro model, we exposed RPE cells to various concentrations of the specific carotenoids, followed by either graded hypoxia or oxidative stress using tert -butyl hydroperoxide (tBHP). (
  • With a modified microcytotoxicity assay, the effects of lymphocytes from normal volunteers and from patients with a variety of solid malignant tumors were tested in vitro against both normal and neoplastic target cells. (
  • This finding, observed in vitro in the cell cultures, was replicated in in vivo experiments in mice, conducted in the lab of Dr. Daniel Herrera, assistant professor of psychiatry at Weill Cornell and an attending psychiatrist at NewYork-Presbyterian/Weill Cornell. (
  • We conducted an in vitro study to determine if products prescribed by a clinic in India have any effect on breast cancer cell lines. (
  • Both ASC and DSC supported in vitro neurite outgrowth and in contrast to Schwann cells, ASC did not induce activation of astrocytes. (
  • The aim of the present study was to investigate the effects of molecular hybrids with 7-chloroquinoline and arylamidine moieties joined through flexible a 2-aminoethanol linker, on the in vitro inflammatory responses to lipopolysaccharides (LPS) induced inflammation in the RAW 264.7 cells. (
  • Second, Giraldez and Krishnaswamy will use human induced pluripotent stem cells (iPSC)-derived neurospheres and organoids from healthy and affected individuals to serve as an in vitro system to study human brain development and function. (
  • Therefore, this thesis examined the effect of coffee and tomatoes on NF-B and inflammation- and cancer related genes in prostate cancer cells both in vitro and in xenografts, as well as studying the tissue accumulation of tomato constituents. (
  • Results: Coffee induced basal NF-κB activity, but inhibited TNF-α induced NF-κB activity in PC3 cells in vitro. (
  • To evaluate the in vitro toxicity of chrysene on human retinal pigment epithelial cells (ARPE-19). (
  • Chrysene in all concentrations used in this study significantly decreases retinal cell viability in vitro, induces JC1, ROS, and caspase 3/7 activity. (
  • A similar approach might ward off cell death in the brains of people afflicted with Parkinson's disease, the team suggested in a study reported online in the journal Cell on August 15 ( abstract ). (
  • Now we can test thousands of compounds, eventually defining a candidate drug that has little effect on normal stem cells but kills the cells that start the tumor," commented Bhatia in the statement. (
  • In addition, APE treatment resulted in a marked increase in maspin, a tumor suppressor protein that negatively regulates cell invasion, metastasis, and angiogenesis. (
  • Finding new treatments for cancer requires detailed studies of tumor cells, but when cells are grown in a lab on Earth, gravity affects the way they grow and the shapes they take. (
  • The cells are expected to form three-dimensional multicellular tumor spheroids (MCTS), which clearly resemble the respective originating tumor. (
  • To test this hypothesis, we investigated the effects of silicon dioxide nanoparticles on two human brain tumor cell lines (SK-N-SH, a neuroblastoma line and U87, an astrocytoma line) employing light microscopy, lactate dehydrogenase release into the culture medium (an indicator of cell damage and necrosis) and MTT assay (an indicator of cell survival). (
  • In the first two phases of the study, lymphocytes from both normal volunteers and cancer patients were frequently toxic on both tumor cells and fibroblasts. (
  • Cancer patient lymphocytes were more frequently toxic on tumor cells but no more frequently toxic on fibroblasts than were normal lymphocytes. (
  • Results of the last phase of the study raise the possibility that both specific and nonspecific reactions may contribute to the toxicity observed in this laboratory with cancer patient lymphocytes tested against tumor cells. (
  • A microchip patterned with arrays of single cancer cells can be an effective platform for the study of tumor biology, medical diagnostics, and drug screening. (
  • Exposure of human cells in culture to chlorhexidine at concentrations equal to or greater than 0.004% resulted in impaired cellular function and/or cell death. (
  • Exposure of cells to 0.2% chlorhexidine for 30 seconds produced maximal suppression of protein synthesis and release of 51Cr. (
  • Indeed, exposure to exogenous estrogen was found to promote the viability of ER-positive ovarian cancer cell lines [ 11 , 12 ]. (
  • So far, the European Commission, focused on ensuring its market players lead the way in advanced wireless services, has rejected pausing to consider the human health effects of 5G, stating that most "5G networks are expected to use smaller cells than previous generations with lower electromagnetic fields exposure levels" and "[t]he introduction of 3G and 4G has not increased exposure from environmental fields. (
  • The FCC standard for measuring the health effects of electromagnetic radiation is based on whether the exposure, on average, will heat human tissue over short periods (six minutes for occupational work and 30 minutes for public exposure). (
  • There are a growing number of stories, videos and websites about the mounting research and science regarding the harmful effects of wireless technologies on our bodies (this is why many organizations want to repeal or modify the U.S. Telecommunications Act of 1996 because the current exposure standards do not take into account recent scientific findings). (
  • The effect of exposure to silica inhalation on two cytochrome-P450 dependent enzymes (ethoxycoumarin-deethylase and ethoxyphenoxazone-deethylase) in the lung microsomal fraction was studied in male Sprague-Dawley-rats. (
  • Exposure to silica had no statistically significant effect on the induction ratio for either activity. (
  • PAF exposure enhanced ethoxyphenoxazone- deethylase activity in whole cells but not in microsomal or sonicated whole cell preparations. (
  • Data obtained from this experiment is compared to the thyroid cancer cells characterized after exposure to simulated microgravity and after the successful SIMBOX on Shenzhou-8 mission (2011, Experiment 14). (
  • Our results indicate exposure to SiO2 nanoparticles led to cytotoxic damage (as indicated by LDH release) and decreases in cell survival (as determined by the MTT assay) in SK-N-SH and U87 cells in a dose-related manner, their effect being more pronounced in SK-N-SH cells. (
  • In the simultaneous culture system, stromal cell exposure to hydroquinone and benzoquinone produced dose dependent decreases in granulocyte monocyte colonies. (
  • Using high-density gene expression arrays, we describe genes that are normally expressed in a subset of human airway epithelial cells obtained at bronchoscopy (the airway transcriptome), define how cigarette smoking alters the transcriptome, and detail the effects of variables, such as cumulative exposure, age, sex, and race, on cigarette smoke-induced changes in gene expression. (
  • Rabies purified chick embryo cell vaccine is used to protect people who have been bitten by animals (post-exposure) or otherwise may be exposed to the rabies virus (pre-exposure). (
  • Survival studies were performed on MC3T3 cells and Staphylococcus epidermidis bacteria, after exposure to Cu ions concentrations ranging from 9 × 10 −3 to 9 × 10 −12 g/mL. (
  • The investigation of the acute cyto- and genotoxicity is studied on cultivated human lung cell line (A549) right after the exposure with test gases at the air / liquid interface (ALI). (
  • Pre-incubation of ARPE-19 cells with lutein or lycopene protected against tBHP-induced cell loss and cell co-exposure of lutein or lycopene with tBHP essentially neutralized tBHP-dependent cell death at tBHP concentrations up to 500 μM. (
  • Hyperthermia exposure of cytotoxic T-lymphocyte generated in mixed leukocyte culture immediately before assay against allogeneic blast cells strongly inhibited their activity. (
  • Some alterations in the kinetics of stimulation with the B-cell mitogen Staphylococcus aureus bacteria were observed after heat exposure although maximal stimulation was at control levels. (
  • Similarly, changes in RNA for superoxide dismutase-1, heme oxygenase-1, and cyclooxygenase-2 were also greatest after silica and the desert dusts supporting an oxidative stress after cell exposure. (
  • Before drug exposure, the cells were incubated for 24 hours in fetal bovine serum free medium to make them relatively non-proliferating. (
  • After 24 hours of chrysene exposure, the following assays were performed: trypan blue dye exclusion to measure cell viability (CV), JC-1 to measure changes in mitochondrial membrane potential (ΔΨM), caspase-3/7 as an indicator of apoptotic activity and the 2', 7' dichlorodihydrofluorescein diacetate (DCFH-DA) assay to measure accumulation of reactive oxygen species (ROS). (
  • The researchers were better able to understand the specificity after comparing proteins in leukemia to normal blood cells. (
  • The immune system recognizes foreign substances in the body by finding proteins called antigens on the surface of those cells. (
  • Immune cells called T cells have their own proteins called receptors that attach to foreign antigens and help trigger other parts of the immune system to destroy the foreign substance. (
  • Surprisingly this time, the cells grew flat in both environments, likely because a launch delay allowed buildup of proteins around the cells and anchoring them together flat. (
  • Future studies on the response of cancer cells to microgravity could help identify the specific proteins that trigger cell changes in space. (
  • Nick Melosh describes a method for sampling RNA and proteins from cells using nanostraws. (
  • A new type of biomolecular tweezers could help researchers study how mechanical forces affect the biochemical activity of cells and proteins . (
  • Scientists have been able to study how single cells or proteins are affected by mechanical forces, but their activity can vary considerably from cell -to- cell and among molecules . (
  • The new tweezers, which are built using nanolithography , can facilitate studying thousands or more cells and proteins in aggregate. (
  • One theory holds that alcohol-mediated stimulation of the heat shock pathway might trigger genes that help mop up mis-folded proteins that can damage cells. (
  • These effects were accompanied by altered expression of the cell cycle regulatory proteins, including downregulation of phosphorylated Rb and upregulation of the CDK inhibitor p27, which were likely responsible for the cell cycle delay/arrest as well as induction of the apoptotic cascade that manifested in the activation of caspase 7 and cleavage of PARP in the treated cells. (
  • Growth factor stimulation of the stem cells resulted in increased secretion of these proteins. (
  • These findings indicated that the inhibited enzymes, oxidative stress, and the down-regulation of Sertoli cell function-related proteins play pivotal roles in CP-induced testicular damage. (
  • A group of researchers from McMaster University have found a new drug that can kill cancer stem cells in humans while avoiding the toxic side effects of other traditional cancer treatments. (
  • Over the past 15 years, researchers have thought that stem cells were the cause of many cancers. (
  • Canadian researchers first discovered cancer stem cells in particular types of leukemia in 1997. (
  • The researchers were screening hundreds of compounds to find those cells that would selectively inhibit human cancer stem cells. (
  • In continuing the project, the researchers want to look at the effects of thioridazine in clinical trials. (
  • Researchers at the Buck Institute and elsewhere now show that chemotherapy triggers a pro-inflammatory stress response termed cellular senescence, promoting the adverse effects of chemotherapy as well as cancer relapse and metastasis. (
  • The new approach enables researchers to analyze the initial reaction of cancer cells to PARP inhibitors with great precision. (
  • The high-throughput method employed by UZH researchers is particularly useful for this kind of problem: Cells can be tested in multiple conditions with short turnover times, and specific genes can be eliminated one by one in a targeted manner. (
  • Researchers report evidence in yeast cells that nucleosomes inhibit binding and cleavage by the genome-editing enzyme CRISPR-Cas9, suggesting nucleosome position maps might help improve genome-editing efficiency. (
  • In a new study, however, researchers from the Fred Hutchinson Cancer Research Center in Seattle were able to use genetically modified stem cells to protect the bone marrow. (
  • Researchers took bone marrow from patients with brain cancer and isolated the stem cells. (
  • In the new study, the researchers observed the effect of CBT on these cell markers in 46 patients with social anxiety disorder. (
  • Because transplanted HSCs depend on cell adhesion to colonize bone marrow properly, the researchers explain, inappropriate up-regulation of genes encoding P-selectin may interfere with this process. (
  • In this latest work, the researchers, from Sydney's Royal Prince Alfred Hospital and the University of Sydney, as well as the Sir Charles Gairdner Hospital in Perth, have identified two new types of bystander effects (dubbed types II and III), which increase cell survival when nearby cells are irradiated. (
  • The researchers examined the survival of malignant melanoma cells exposed to a spatially modulated megavoltage photon beam. (
  • The researchers attributed this effect to intercellular communication, in which cells report their DNA integrity to their neighbors. (
  • Clinostats are among the most accessible methods to simulate microgravity, and they allow researchers to study living cells using standard laboratory tissue culture supplies. (
  • Interestingly, however, a team of researchers led by Nagoya University previously found that the occurrence of more germ cells -- biological cells capable of uniting with one from the opposite sex to form a new individual -- in female medaka (teleost fish) gonads is essential for female differentiation of gonads. (
  • In experiments the researchers conducted in mice, treatment with methotrexate was tied to problems in all three types of glial cells. (
  • Following trends seen elsewhere in the sciences," the authors write, "stem cell researchers--and the companies and universities for which they work--are increasingly taking private ownership of early-stage technologies, cell lines, genes and associated data. (
  • He used the analogy of the popular real estate website the Multiple Listing Service, saying there is no equivalent public "MLS" that serves as a property records registry for stem cell researchers. (
  • Working with mouse cells in the lab, the researchers used microarray technologies to search for genes other than Gabra4 that might be activated when the heat shock pathway was exposed to alcohol. (
  • Exactly what those effects might mean clinically remains in the realm of speculation for now, the researchers stress. (
  • Now, a team of researchers at the D'Or Institute for Research and Education (IDOR) sought to reveal the virus reactions on laboratory-created astrocytes, which are among the first cells to respond to ZIKV infection in the brain and are targets for viral infections. (
  • In the new study, the researchers studied three types of brain cells and found that among the cells, the Zika virus has more severe damages to astrocytes. (
  • Neurological toxicity that the researchers have named CAR-T-cell-related encephalopathy syndrome (CRES), which can sometimes lead to lethal swelling in the brain. (
  • The researchers cultured these brain cells in a laboratory dish for three weeks, allowing the neurons time to mature and to develop a dense network of synaptic connections and "dendritic spines"-specialized structures that protrude from the dendrites and are essential mediators of activity throughout neural networks. (
  • Cell viability was examined by MTT assay. (
  • Hispolon decreased cell viability in a dose- and time-dependent manner. (
  • Our data demonstrated that APE, obtained from organic Gala apples, imparted significant reduction in the viability of a variety of cancer cell lines. (
  • Moreover, cell viability was decreased under hypoxic conditions. (
  • The effect was not a consequence of cell death since only a small decrease in cell viability was observed and the viability of density gradient fractions enriched for NK activity was normal. (
  • Several studies, including those undertaken by Dr. Yu's team, suggest that mesenchymal stem cells (MSCs) do indeed improve Crohn's disease and Crohn's fistula. (
  • In this work, we investigated the effects of clinorotation speed on the morphology, cytoarchitecture, and migration behavior of human mesenchymal stem cells (hMSCs). (
  • This thesis investigates the effects of mesenchymal stem cells (MSC) derived from adipose (ASC) and dental (DSC) tissue and chitosan/microRNA-124 polyplex particles on regeneration after spinal cord and peripheral nerve injury in adult rats. (
  • Cytotoxic effects estimated by cell counting after 72 h treatment with salsolinol (IC 50 =38 μmol/l) were possibly caused by mitochondrial damages. (
  • The health risk and cytotoxic effects of nanoparticles are almost unknown. (
  • An initial observation prompted us to hypothesize that SiO2 nanoparticles can traverse the plasma membranes of cells through the endocytosis mechanism and thereby exert their cellular and cytotoxic effects on cells. (
  • In this study, we have investigated the hypothesis that silver and gold nanoparticles exert differential cytotoxic effects on human astrocytoma (glioblastoma) U87 cells. (
  • CAR T-cell therapy is also sometimes talked about as a type of cell-based gene therapy , because it involves altering the genes inside T cells to help them attack the cancer. (
  • One of the up-regulated genes, P-selectin, encodes a cell surface adhesion molecule. (
  • RxPG] NEW YORK (Dec. 7, 2007) -- Alcohol triggers the activation of a variety of genes that can influence the health and activity of brain cells, and new research from Weill Cornell Medical College in New York City sheds light on how that process occurs. (
  • If you are going to understand the biological effects of alcohol on genes within cells, you have to understand the molecular machinery driving the transcription, or activation, of the genes in question. (
  • HSF1 then makes its way to the cell nucleus, where it helps stimulate the transcription and activation of a variety of genes that enable the cell to survive stress. (
  • The identification of DNA-fragmentation and p53 and Ki-67 genes expression suggest that the mechanism of NADH action is different from disregulation of genes considered as check-points in cell cycle. (
  • One of the most important steps in understanding the biology of autism spectrum disorder (ASD) is elucidating the basic neurodevelopmental mechanisms governing cell type specification and how these mechanisms are disrupted due to mutations in ASD-risk genes. (
  • Using these systems, the team will obtain gene expression profiles of neural cells throughout normal development and in cells with loss-of-function mutations in ASD-risk genes. (
  • Q-RT-PCR was used to analyse the effect of coffee and tomatoes on expression of genes related to immunity, inflammation and cancer in PC3 cells in culture and in xenografts. (
  • Conclusions: We found that coffee and tomatoes are strong inhibitors of TNF-α induced NF-κB activity in PC3 cells, and have the ability to modulate a number of genes related to cancer. (
  • Our results may support a preventive role of coffee and tomatoes in prostate cancer, and further research should focus on elucidating the mechanisms behind the effects of coffee and tomatoes on NF-κB activity and expression of genes related to prostate cancer. (
  • The selective epigenetic silencing of the key inflammatory chemokine genes that attract T cells in the decidual stroma is maintained during normal pregnancy [ 2 ]. (
  • Lower doses were capable of inhibiting protein synthesis and releasing 51Cr, but did not result in staining of cells by trypan blue. (
  • After very high doses of radiation series resistance of the base layer could be so high that most of the power generated by the device such as solar cell is dissipated by its own internal resistance. (
  • Small doses of dopamine travel through your brain cells to indicate pleasure or satisfaction. (
  • You need large doses of the order of ~1Gy and above to clearly observe/demonstrate the cell killing in mammalian cells. (
  • Some mutant cell lines, such as AT1BR with ATM and other repair deficiencies, are known to show more radiosensitivity at low doses. (
  • Corticosterone initiated extracellular signal-regulated kinase 1/2 phosphorylation in rat vascular smooth muscle cells at ≥10 −11 mol/L doses. (
  • 1,2,4-Benzenetriol and catechol were not effected at lower doses, but at 0.0001mol they reduced granulocyte monocyte colony formation to 45 and 20 percent of control values, respectively. (
  • Cataracts are more likely to occur in patients receiving steroid doses and typically begin to develop between 18 and 24 months following a stem cell transplant. (
  • TK6 Cells were seeded (30,000 cells/well) on fluorometry compatible 96 well plates (NUNC, Rochester, NY) then exposed to the experimental compounds at ten different doses (in triplicates) for 24 hours. (
  • At lower doses which had little effect on the total number of nuclei, the formation of muscle fibres--that is, fusion of muscle cells--was prevented as the proportion of nuclei in myotubes was decreased. (
  • At higher doses both cell types were killed. (
  • In this study, we evaluated the antiproliferative effects of apple peel extract (APE) in variety of cancer cell types. (
  • Also, the antiproliferative effects of APE were found to be accompanied by a G0-G1 phase arrest of prostate and breast cancer cells. (
  • Our data suggested that APE possesses strong antiproliferative effects against cancer cells, and apple peels should not be discarded from the diet. (
  • We investigated the antiproliferative effects of extracellular nicotinamide adenine dinucleotide against human malignant CaCo-2 (colon carcinoma), Hep-2 (laryngeal carcinoma), MCF-7 (breast carcinoma), CaSki (cervix carcinoma) cell lines, as well as against murine fibrosarcoma and normal human embryonal fibroblast (HEF). (
  • Cell growth and differentiation in each culture were examined by phase contrast microscopy and described both qualitatively and quantitatively. (
  • Those binding differences could drive changes in cell phenotype and affect processes such as cell differentiation. (
  • This would suggest either an effect on muscle differentiation or a selective toxicity towards myoblasts. (
  • Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune responses, and the resolution of inflammation. (
  • In 1998, Peter Henson, Donna Bratton, and colleagues at National Jewish Health demonstrated that phagocytosis of apoptotic cells actively suppresses inflammation by inhibiting the production of inflammatory cytokines and inducing production of antiinflammatory factors, including TGF-β and prostaglandin E2. (
  • In a 1998 paper published in the JCI ( 7 ), we demonstrated that interaction of macrophages with apoptotic cells led to active suppression of their inflammatory mediator production (Figure 1 A). This contributed to the current understanding of apoptotic cells as being generally antiinflammatory (inflammosuppressive) and also immunosuppressive. (
  • Uptake of apoptotic cells was thereby contrasted to other forms of phagocytosis (foreign organisms) and set the stage for demonstration that the removal was not merely silent, but actively antiinflammatory, both in the above-mentioned paper as well as by Voll et al. (
  • 10 ). It also soon led to the recognition that apoptotic cells remain physically intact long enough for this removal to occur before membrane dissolution and the release of potentially inflammatory and immunogenic intracellular contents. (
  • The observation was, in effect, a re-recognition of Metchnikov's observations of macrophages phagocytosing microphages in the 1890s. (
  • The authors conclude that a mediator secreted by activated macrophages can affect a critical detoxication mechanism in another cell type of the alveolar region. (
  • We report down-regulation by BM of NO and TNF-α in stimulated RAW 246.7 macrophages and of IFN-γ in stimulated human blood cells. (
  • Macrophages are among the main cells involved in generation of inflammation. (
  • These pathways were shown to be highly evolutionarily conserved across metazoa, including mammals, during development, tissue remodeling, and removal of inflammatory cells. (
  • It also emphasized the active role played by apoptotic cell recognition in the resolution of inflammation: not only removing the inflammatory cells, but also turning off the mediators that attracted them in the first place. (
  • Of them, wogonin from traditional Chinese herb Scutellaria baicalensis Georgi has been widely used and researched for allergic and inflammatory diseases with its medication effects of potential "cleansing heat" and "removing toxins" [ 20 , 21 ]. (
  • That's because senescent cells are not benign - they secrete inflammatory molecules that damage neighboring tissues and cells. (
  • Aging HSCs exhibit a functional decline (yet an increase in cell number) and display a heightened stress and inflammatory response along with signs of epigenetic erosion. (
  • Anti-inflammatory effects of Calophyllum inophyllum L. in RAW264.7 cells. (
  • Taken together, these observations show that CIL extract has anti-inflammatory effect, which extends the potential application for prevention of inflammatory diseases, and its mechanism may be partially associated with blocking COX-2 and iNOS of RAW 264.7 cells. (
  • In aged animals, treatment with senolytic modulated the inflammatory response by decreasing recruitment and activation of myeloid and phagocytic cells. (
  • We conclude that, comparable to other particles, desert dusts have a capacity to 1) influence oxidative stress and release of pro-inflammatory mediators in respiratory epithelial cells and 2) provoke an inflammatory injury in the lower respiratory tract of an animal model. (
  • Inflammatory reactions in the RAW264.7 cells were induced using E. coli lipopolysaccharides (LPS). (
  • And it has been reported that dexmedetomidine has an anti-inflammatory effect. (
  • In this study, we examined the influence of dexmedetomidine on the expression of cyclooxygenase-2 (COX-2), prostaglandin E 2 (PGE 2 ) and inflammatory cytokines in lipopolysaccharide (LPS)-stimulated human amnion-derived WISH cells. (
  • In addition, we evaluated the association of mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) pathway in anti-inflammatory effect of dexmedetomidine. (
  • In addition, this study suggests that anti-inflammatory effect of dexmedetomidine on WISH cells was mediated by the inhibitions of p38 and NF-κB activation. (
  • The effect of PAF may be mediated through a permeability mechanism or through the reversal of an inhibitory process. (
  • Blockage of LPS-induced ERK, JNK, Akt, and NF-kappaB activation contributed to the inhibitory effect of quercetin on DCs. (
  • Other estrogenic chemicals, including beta-estradiol, diethyl stilbestrol and p-octylphenol did not show significant inhibitory or promoting effects. (
  • Tomatoes had a strong inhibitory effect on TNF-α induced NF-κB activity in PC3 cells. (
  • The results indicate that lutein and lycopene, but not β-carotene, inhibit cell growth in undifferentiated ARPE-19 cells. (
  • In this study, we investigated the molecular and biological effects of wogonin in human ovarian A2780 cancer cells. (
  • Diethylhexyl phthalate and its metabolite 2-ethyl-1 - hexanol (2-EH) have demonstrated biological effects which merit further evaluation. (
  • This work aims to build our knowledge of 2-EH and further establish a comparison of the biological effects among DEHP and 2-EH. (
  • Biological effects of desert dust in respiratory epithelial cells and a murine model. (
  • The biological effects of desert dusts approximated those of silica. (
  • Our findings reveal a dual metabolic nature of cancer cells, which is critical for their survival and growth. (
  • Further, our data showed a significant decrease in growth and clonogenic survival of human prostate carcinoma CWR22Rnu1 and DU145 cells and breast carcinoma Mcf-7 and Mcf-7:Her18 cells. (
  • Storage of red cells is associated with a storage lesion and the survival of transfused red cells decreases with increasing storage time, thus older blood is associated with an increased acute delivery of hemoglobin-iron to the reticuloendothelial system. (
  • First, we demonstrate that cyclosporin A acts directly on NPCs to enhance their survival and modify cell-cell adhesion. (
  • The selective effect of cyclosporin A on NPC survival suggests that cyclosporin A is a promising molecule for modulating NPCs. (
  • Traditionally, such radiobiological models assume that cell survival is directly related to the local radiation dose. (
  • Cell survival is also influenced by the fate of neighboring cells -- the so-called bystander effect. (
  • Previous research has identified the existence of a classical (type I) bystander effect, in which a cell's survival is reduced when communicating with irradiated cells. (
  • Following irradiation, survival fractions were calculated by comparing the survival of irradiated cells with that of unexposed control cells. (
  • The most significant difference in survival fraction was found between the cells exposed to a uniform radiation field and those exposed to the partially shielded fields, where unirradiated cells were present," Mackonis told medicalphysicsweb . (
  • Upon irradiation with either modulated field, cells in the shielded regions showed enhanced survival compared with those receiving the same dose from a uniformly shielded field. (
  • For example, when the unshielded region received a lethal dose of 10 Gy, the shielded cells (which received a leakage dose of 0.5 Gy) showed survival fractions of 0.97 and 0.85 for the striped and quarter fields, respectively. (
  • Cells receiving 0.5 Gy from a uniformly shielded field exhibited a lower survival fraction of 0.78. (
  • These results imply the existence of an effect in which cells receiving a low scattered radiation dose exhibit increased survival when neighboring cells receive a lethal dose: the type II bystander effect. (
  • In the unshielded regions, cell survival decreased with increasing dose for all field modulations, with few cells surviving at 10 Gy and above. (
  • Cells receiving a direct 3 Gy dose from a modulated field demonstrated increased survival fractions (0.53 and 0.71 for striped and quarter fields, respectively), compared with cells receiving 3 Gy from a uniform field (0.28). (
  • The small leakage dose to the shielded region may act as a "conditioning dose" and elicit an adaptive response that causes shielded cells to signal to their unshielded neighbors and so increase their survival. (
  • Our results demonstrate silver and gold nanoparticles induced time- and concentration-related effects in lowering the survival of U87 cells. (
  • We conclude that corticosterone induces rapid mineralocorticoid receptor signaling in vascular smooth muscle cells that involves mitogen-activated protein kinase kinase/extracellular signal-regulated kinase-dependent pathways. (
  • Due to highly energetic photons, UVB more efficiently than UVA induces changes in the skin causing a carcinogenic DNA damage and various epigenetic effects [ 2 , 4 ]. (
  • Using the respiratory epithelial cell line BEAS-2B, the two desert dusts increased oxidant generation, measured by Amplex Red fluorescence, along with carbon black (a control particle), silica, and NIST 1649 (an ambient air pollution particle). (
  • Varying Cu concentrations in solution were introduced to bacteria (Staphylococcus epidermidis) and cells (MC3T3 murine calvarial osteoblasts), and it was found that the lethal dosage for Cu ions was in the range from 9x10 -5 to 9x10 -6 g/ml, for bacteria and cells. (
  • Quercetin enhanced melanin production per cell in cultured murine B16-F10 melanoma cells, but this effect may be due in part to melanocytotoxicity. (
  • As a result of the challenge of dust storms to public health, we tested the postulate that southwestern USA derived desert dust could impact a biological effect in human respiratory epithelial cells and an animal murine model. (
  • To determine effects of seven quinoline-arylamidine hybrids on the growth of the murine macrophage-like (RAW 264.7) cells MTT assay was used. (
  • NADH was very potent in the growth inhibition of murine fibrosarcoma and human Hep-2 cells, regardless of the dose applied. (
  • Neurons, imaginal disk cells and plasmatocyte-like cells barely differentiated in male ( Zw n /Y) cultures, whereas muscle and fatbody cells were not so severely affected. (
  • The new study focused on how chemotherapy affects the brain's "helper cells," called glial cells , which provide support for the brain's neurons. (
  • In research conducted in cell cultures and in mouse neurons in vivo, his team found that alcohol stimulates a ubiquitous, stress-linked biochemical cascade -- called the heat shock pathway -- to send a molecule called heat shock factor 1 (HSF1) into the neuron's nucleus. (
  • Head direction (HD) cells are neurons found in a number of brain regions that increase their firing rates above baseline levels only when the animal's head points in a specific direction. (
  • The telomeres are in turn protected by the enzymes telomerase (the job of which is to rebuild them) and glutathione peroxidase (which protects the cells against oxidative stress). (
  • In our interpretation, it means that effective psychological treatment for anxiety can protect the cells against oxidative stress and cellular ageing," Månsson said. (
  • It is likely that the time frame required to exert an effect in the brain reflects regulation by BM of chronic inflammation and oxidative stress associated with aging and chronic diseases, and other polypharmacological effects. (
  • This study was designed to investigate effects of various carotenoids (β-carotene, lycopene, and lutein) on RPE cells subjected to either hypoxia or oxidative stress, in order to determine if there is effect specificity for macular pigment carotenoids. (
  • Our findings indicate that lutein and lycopene inhibit the growth of human RPE cells and protect the RPE against oxidative stress-induced cell loss. (
  • During infection, the mitochondria in the astrocytes, which is the powerhouse of the cell and responsible for cellular respiration, changes and starts to produce free radicals, triggering oxidative stress. (
  • Growth was investigated by incubating cells with various concentrations of hispolon (25 and 50 µM) for 24, 48 or 72 h and daily cell count. (
  • 3 Although aldosterone has been seen as the culprit, glucocorticoids bind to the MR with the same affinity at physiological concentrations and exert similar effects on various targets, including vessels. (
  • Bone marrow cell suspensions were prepared from male B6C3F1-mice and cultured with hydroquinone (123319), benzoquinone (106514), catechol (120809), phenol (108952), and 1,2,4-benzenetriol (533733) at concentrations from 0.0000015 to formed in the presence of these metabolites was determined and compared with values from untreated stromal cell cultures. (
  • Stromal cells exposed to metabolites at these same concentrations were also cultured simultaneously with fresh bone marrow cells in agar to measure the effect on the ability of stromal cells to support growth of granulocyte monocyte colony forming cells. (
  • Hydroquinone completely inhibited cell growth at concentrations above 0.0000125mole, and benzoquinone had the same effect at a concentration of 0.00005mol. (
  • At a concentration of 0.00005mol catechol decreased colony formation 40 percent, but greater concentrations had similar effects. (
  • Given the burden of lung disease created by cigarette smoking, surprisingly few studies ( 7 , 8 ) have been done in humans to determine how smoking affects the epithelial cells of the pulmonary airways that are exposed to the highest concentrations of cigarette smoke or what smoking-induced changes in these cells are reversible when subjects stop smoking. (
  • In this study, the objective was to investigate the copper ion concentrations at which cyto-toxicity is avoided while bacterial inhibition is ensured, by comparing Cu ion effects on selected eukaryotes and prokaryotes. (
  • Two-way ANOVA was used to assess the effects of OH-PCBs and other chemicals on both factors of their concentrations and with/without T4 in the assay of TH-dependent dendritic development of Purkinje cells. (
  • After treatment with a range of MIC concentrations (0.025-0.5 microliter/5 ml culture) the total number of nuclei of the two main cell types (fibroblasts and myoblasts) and the number of nuclei in muscle fibres (myotubes) were recorded. (
  • Equivalent PSC concentrations were approximately 1/10(5) fresh marrow cells, and were about twofold lower using previously transplanted marrow. (
  • Human amnion-derived WISH cells were pretreated with various concentrations of dexmedetomidine (0.001-1 µg/ml) for 1 h and after then treated with LPS (1 µg/ml) for 24 h. (
  • ARPE-19 cells were exposed to different concentrations of Chrysene diluted in DMSO (250µM, 500µM, 750µM and 1000µM). (
  • A thermogalvanic cell can be seen as analogous to a concentration cell but instead of running on differences in the concentration/pressure of the reactants they make use of differences in the "concentrations" of thermal energy. (
  • Standard chemotherapy is a blunt force instrument against cancer - and it's a rare cancer patient who escapes debilitating side effects from systemic treatments that mostly affect dividing cells, both malignant and healthy, throughout the body. (
  • The data presented here indicate that the methodology of cell cloning can be applied to different types of malignant cells. (
  • They target CD19, a protein found on the surface of both malignant and normal B cells. (
  • Podoplanin, a platelet aggregation-inducing sialoglycoprotein, has been reported to be expressed in many cancers including squamous cell carcinomas (head and neck, lung, esophageal), malignant brain tumors, malignant mesotheliomas, and testicular tumors. (
  • Our results support the findings of numerous short-term studies that found no significant endothelial cell loss after LASIK and PRK," the authors write. (
  • Our findings of no difference in endothelial cell loss after keratorefractive surgery compared with normal eyes suggests that corneas after keratorefractive surgery should be suitable for posterior lamellar keratoplasty," a surgical treatment for corneal dysfunction that involves donor tissue. (
  • These findings may explain the immunomodulatory effects of older stored blood in patients and will help us develop safer transfusion products for patients. (
  • This report focuses on the STRRIDE findings pertinent to β-cell function. (
  • Here, we extend upon these findings by ablating newly generated cells after the epileptogenic insult using a conditional, inducible diphtheria-toxin receptor expression strategy in mice. (
  • These findings provide the first proof-of-concept data demonstrating that granule cell ablation therapy applied at a clinically relevant time point after injury can have disease-modifying effects in epilepsy. (
  • SIGNIFICANCE STATEMENT These findings support the long-standing hypothesis that newly generated dentate granule cells are pro-epileptogenic and contribute to the occurrence of seizures. (
  • The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. (
  • As ECAR and OCR reflects the glycolytic rate and OXPHOS, this 5-fold reduction of the glycolytic rate without obvious change of OCR suggests that cells under lactic acidosis is not glycolytic and relies more on OXPHOS for ATP generation. (
  • And a 2014 review suggests many of the long-term cognitive effects of cocaine use are actually connected to withdrawal from cocaine. (
  • This suggests the effects of microgravity can be modified and may explain delayed formation of single-cell-wall tubes in space. (
  • A new study suggests stem cells may be able to act as a 'shield' to protect the body from the harmful side effects of chemotherapy, the BBC News reported. (
  • Unfortunately, new evidence published in the open-access journal PLoS Biology suggests that this regenerative capacity also declines with age as stem cells acquire functional defects. (
  • A study of juvenile rat brain cells suggests that the effects of a commonly used anesthetic drug on the connections between brain cells are temporary. (
  • This suggests that the same PSC produced lymphoid and myeloid cells, and that most circulating cells were descended from the same PSC over hundreds of days. (
  • Beside the diversity of the device technologies used for designing the solar cells and various optoelectronic devices, there are a variety of radiation environments in which they are used (natural space and atmospheric, as well as military and civil nuclear environments, etc. (
  • On the other hand, γ radiation damage is induced by the ionization and excitation of the atoms within the junction space charge region of a junction device such as solar cell. (
  • This special issue reveals recent developments in the vastly undertaken investigations concerning radiation effects in various optoelectronic devices (solar cells, photodiodes, phototransistors, insulating layers, memories, dosimeters, etc. (
  • Meanwhile, scientists don't agree on the effects of radiation from wireless communications, and some argue that the standard needs to be reevaluated. (
  • 1. Do cell towers emit radiation? (
  • Re: Which rapidly dividing cells can show the effects of ionizing radiation? (
  • Nausea and vomiting are common side effects of both radiation and chemotherapy. (
  • Many common side effects, such as nausea, vomiting, fatigue and temporary hair loss, are due to chemotherapy or radiation therapy. (
  • isolated HSCs from young (aged 2 months) and old (aged 21 months) mice and then transplanted either young or old cells into mice whose bone marrow cells had been destroyed by radiation. (
  • Incorporating models that describe the effects of radiation upon tissue into radiotherapy treatment plans should improve treatment outcomes. (
  • One possible explanation for this process is that when the exposed cells receive a lethal radiation dose, their death stimulates a repair mechanism in the viable cells within the shielded region. (
  • Dendritic cells (DC) are key players in innate and adaptive immunity. (
  • This review discusses the effect of HHV-6 on dendritic cells (DC). (
  • Quercetin's immunosuppressive action on dendritic cell activation function indicate it may play a therapeutic role in autoimmune, hypersensitivity, and/or organ transplantation. (
  • Dendritic cells (DCs) play a crucial role in linking innate and adaptive immunity. (
  • The activation of CLEC-2 by podoplanin rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces. (
  • Hippocampal cells with neuron in green showing hundreds of the small protrusions known as dendritic spines. (
  • After receiving an injection of their own adipose-derived stem cells (ASC), which are collected from fat tissue, the fistulas in 75 percent of the trial participants were completely healed within eight weeks of their last treatment and remained so two years later. (
  • Takeda and TiGenix have presented 52-week data on their allogeneic expanded adipose-derived stem cells in Crohn's disease patients with treatment-refractory complex perianal fistulas. (
  • Avoid acupuncture if you have a low white blood cell count, because you may be at higher risk of infection. (
  • Infection is one of the most common early side effects of a stem cell transplant. (
  • Infection occurs after stem cell transplant because the white blood cell count is very low and the immune system is very weak. (
  • The risk of infection for all types of transplant is high until the bone marrow starts to make white blood cells, which is called engraftment. (
  • Even if there is no sign of infection, most people are given antibiotics or antiviral drugs until their white blood cell counts start to rise. (
  • Doctors may also prescribe colony-stimulating factors (CSFs), such as filgrastim (Neupogen) or pegfilgrastim (Neulasta), following a stem cell transplant to help lower the risk of infection and speed up engraftment. (
  • Infection can also occur long after a stem cell transplant. (
  • A low white blood cell count (neutropenia or leukopenia) increases the risk for infection. (
  • Doctors may also prescribe a colony-stimulating factor (CSF) such as filgrastim (Neupogen) following a stem cell transplant to help lower the risk of infection and speed up the process of making new blood cells. (
  • In this review the effects of HHV-6 infection on DC will be discussed. (
  • These cells fight infection. (
  • If the number of white blood cells is low, you are more likely to get an infection. (
  • Following chemotherapy and a stem cell transplant, a patient's immune system ability and the number of white blood cells in the body will be reduced, making her more susceptible to infection. (
  • However, antibiotics and mouthwashes will typically be prescribed in order to avoid infection following a stem cell transplant. (
  • Bone marrow failure subsequently causes an insufficient production of red blood cells, white blood cells and platelets in the blood, leading to infection, anaemia or bleeding. (
  • Four randomized clinical trials [6-9] evaluated the effects of hydroxyurea-based antiretroviral regimens in HIV patients at various stages of infection, except during primary HIV infection (PHI). (
  • Children with sickle cell disease are at risk for serious morbidities related to vascular occlusion, hemolysis (break down of red blood cells before their time of 120 days), and infection that can impair their quality of life and lead to early death. (
  • hough previous studies have been made about the damage of the Zika virus on the brain, particularly astrocytes, only a few ones proposed to determine the effects of the infection on the cells. (
  • In laboratory mice, the astrocytes showed more vulnerability to the infection, compared to other cells. (
  • by changing them into cells that are non-cancerous," explained Mick Bhatia , the principal investigator for the study and scientific director of McMaster's Stem Cell and Cancer Research Institute in the Michael G. DeGroote School of Medicine, in a prepared statement. (
  • The anti-psychotic drug, thioridazine, showed to have no effect on normal stem cells in the study. (
  • Because endothelial cells are an important element of this barrier the present study was designed to assess the influence of salsolinol (a TIQ formed by condensation of dopamine and acetaldehyde) on cultivated endothelial cells by physiological, biochemical and morphological investigations. (
  • Therefore, from the technological point of view, it is important to study the variations induced by irradiation of semiconductor junction characteristic parameters (ideality factor, saturation current, etc.) that affect the performance of the solar cells, photodiodes, phototransistors, and other photonic devices. (
  • Our study further showed that MPP, a specific ER- α inhibitor, significantly enhanced antitumor effects of wogonin in A2780 cells. (
  • Chemotherapy-induced bone marrow injury can lead to reduction in blood cell production, which can contribute to chemotherapy-induced fatigue,' Said Daohong Zhou, MD, Associate Director for Basic Research of the Winthrop P. Rockefeller Cancer Institute at the University of Arkansas for Medical Sciences in Little Rock and a co-author of the study, 'Eliminating senescent cells can promote bone marrow recovery after chemotherapy. (
  • The purpose of this study is to determine the effects of transfusion of fresh and stored blood on patients. (
  • The study looked at the effects of moringa on esophageal cancer, a type of cancer diagnosed in many members of South Africa's black population. (
  • Our previous models and a catalyst-layer model are combined to study the effects of microporous layers in polymer electrolyte fuel cells. (
  • Extracts from Ashwagandha root may significantly increase telomerase activity, thereby protecting against telomere loss and potentially delaying aging, suggest new results from a cell study. (
  • This is the first published study to use a standardized, branded ashwagandha extract that show an anti-aging effect with a telomerase promotion effect in the human cell line. (
  • This allowed both the study of a more uniform population and the study of sensitive and resistant cells prior to the addition of the drug with both S-FTIR and Raman microspectroscopies. (
  • This finding implies that, in addition to the most well- known role of germ cells developing into eggs or sperm and produce the next generation, germ cells have a unique and surprising potential to change their surrounding environment," says Toshiya Nishimura, first author of the current study. (
  • In their latest study, they generated three different medaka mutants to demonstrate that the feminizing effect of germ cells is not a result of the progression of gametogenesis or a sexual fate decision of germ cells. (
  • The mechanisms of the Qigong effects observed in this study are as yet unclear. (
  • In this study, we examined the effect of quercetin, a natural flavonoid found in many vegetables and fruits, on the activation and function of mouse DCs. (
  • Now, a new animal study, published today (Dec. 6) in the journal Cell , provides insight into how certain chemotherapy drugs affect brain cells. (
  • The present study also demonstrates that granule cell ablation, while reducing seizure frequency, paradoxically increases seizure duration. (
  • Arrays of the tweezers could be combined to study multiple molecules and cells simultaneously, providing a high-throughput capability for assessing the effects of mechanical forces on a broad scale. (
  • Because the forces can be varied, the tweezers can be used to study structures of widely different size scales, from protein molecules to cells -- a size difference of approximately a thousand times, noted Wilbur Lam, an assistant professor in the Coulter Department. (
  • This study found that a daily hydroxyurea pill may finally bring some relief for young children living with sickle cell anemia. (
  • This study provided evidence for a noted relationship between processing speed and parameters in sickle cell anemia and model risk factors. (
  • This study enforces previous reports of white matter injury in sickle cell leading to possible functional consequence of this kind of injury. (
  • In the last phase of the study, normal lymphocytes were less frequently toxic on both types of target cells. (
  • The different results obtained in the last phase of the study cannot be attributed solely to the different method of lymphocyte separation, since other factors, such as better growth status of the target cells and greater facility in performing the assays, might also be responsible. (
  • The present study demonstrates that human natural killer (NK) cells isolated from peripheral blood of normal individuals are highly sensitive to hyperthermia. (
  • The aim of the study was to investigate the effects of glucocorticoids in cultured human lens epithelial cells. (
  • This study examines the effect of both cell area and depth upon the growth of juvenile blue crabs. (
  • Specifically, a separate-cell hatchery system will be used to produce adults that can be used for study or for spawning. (
  • The new study, published in the journal Scientific Reports , shows how the virus damages laboratory-created astrocytes and comparing them to the same cells present in the brain tissue of animals and fetuses infected with the virus. (
  • The aim of this study was to evaluate the potential effects of CP in the testes of rats. (
  • Thus, to study trkA-mediated actions of NGF on these cells we transiently expressed the receptor by transfection with a vector containing a full-length rat trkA complementary DNA under transcriptional control of the cytomegalovirus promoter. (
  • The Department of Molecular Mechanisms of Disease of the University of Zurich uses cancer cell cultures to investigate the exact effects of this new group of drugs. (
  • Cell cultures were maintained in RPMI 1640 culture media with 10% fetal bovine serum (ATCC). (
  • However, as compared to fed-batch processes, product quality and cell specific productivity differences were observed in perfusion cultures. (
  • Chimeric antigen receptor (CAR) T-cell therapy is a way to get immune cells called T cells (a type of white blood cell) to fight cancer by changing them in the lab so they can find and destroy cancer cells. (
  • In CAR T-cell therapies, T cells are taken from the patient's blood and are changed in the lab by adding a gene for a man-made receptor (called a chimeric antigen receptor or CAR ). (
  • For example, in certain kinds of leukemia or lymphoma, the cancer cells have an antigen called CD19. (
  • The CAR T-cell therapies to treat these cancers are made to attach to the CD19 antigen and will not work for a cancer that does not have the CD19 antigen. (
  • Their work, published recently in Nature Reviews Clinical Oncology, confronts the two main side effects of chimeric antigen receptor T cells, known as CAR T cells, white blood cells genetically engineered to strike cells with a specific target on their surface. (
  • We used clonal βHC9 cells, which derive from hyperplastic islet cells of transgenic mice that express the SV40 T-antigen under the control of an insulin promoter ( 10 ). (
  • 2009) Detection of five different cells' sensitivities to enterovirus 71 using plaque forming assay World Journal of Gastroenterology, in Chinese, 17(6), 573-577. (
  • Analysis of NK activity at the single-cell level by application of a conjugation assay in agarose revealed that hyperthermia interfered with target cell binding as well as the lytic cycle. (
  • Our work in mice studied the effects of chemotherapy on cancer relapse and other serious side effects. (
  • Results showed that eliminating chemotherapy-induced senescent cells reduced several short-and long-term effects of treatment, including bone marrow suppression, toxicity to the heart, cancer recurrence and metastasis, and physical activity and strength. (
  • Women who went into chemotherapy with the highest existing burden of senescent cells experienced the most debilitating fatigue after treatment,' he said. (
  • It didn't really matter what particular drug was used - the results following chemotherapy tracked to the existing burden of senescent cells. (
  • We also think it would be great to mitigate the other side effects of chemotherapy, the fear of which sometimes keep patients from seeking treatment. (
  • The bone marrow is very susceptible to chemotherapy, and in response to the treatment, produces less blood cells. (
  • They infected the cells with a virus which carried a gene to protect the cells against a chemotherapy drug, and then re-implanted the cells into the patients. (
  • We found that patients were able to tolerate the chemotherapy better, and without negative side effects, after transplantation of the gene-modified stem cells than patients in previous studies who received the same type of chemotherapy without a transplant of gene-modified stem cells," Professor Hans-Peter Kiem told the BBC News. (
  • Furthermore, the type of high-dose chemotherapy treatment regimen used, as well as the type of treatable disease and the patient's medical status, are all factors that may contribute to the risk of certain transplant side effects. (
  • Interstitial Pneumonia Syndrome (IPS) occurs when high-dose chemotherapy results in damage to the lungs and can occur at any time following a stem cell transplant. (
  • Chemo brain," the problems with thinking and memory tied to chemotherapy, can be a frustrating and even debilitating side effect of cancer treatment. (
  • Scientists know that chemotherapy drugs target the body's rapidly dividing cells, such as hair follicles , but exactly how the drugs affect brain cells is not fully understood. (
  • The experiments suggested that chemotherapy affects the cells in the following way: Methotrexate treatment leads to long-term activation of microglia, which in turn, leads to inflammation that appears to cause problems for both oligodendrocytes and astrocytes. (
  • It takes time for stem cells to make their way to the bone marrow and start making new blood cells (called engraftment). (
  • Depending on the type of stem cell transplant performed, such as a bone marrow transplant or cord blood transplant , the risk of developing certain complications either increases or decreases. (
  • Graft failure occurs when the stem cell graft fails to grow following a stem cell transplant, resulting in bone marrow failure. (
  • The length of the telomeres decreases with every cell division, meaning that they grow shorter with age. (
  • Our results show that EV71 proliferates in the neural cells and leads to neural cell lesions. (
  • The principle aim of NanoRacks-CellBox-Effect of Microgravity on Human Thyroid Carcinoma Cells (NanoRacks-CellBox-Thyroid Cancer) is to investigate the effects of real microgravity on human thyroid carcinoma cells (FTC-133 cell line). (
  • The purpose of Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE), a large, randomized, controlled clinical trial, was to investigate the effects of different amounts and intensities of exercise training on numerous cardiometabolic risk factors. (
  • In this paper, we investigate the effect of the salt concentration on the operation of light-emitting electrochemical cells, using experiments and numerical calculations. (
  • In order to investigate the impact of hydroxyurea cytostatic effects during PHI, we evaluated the changes in peripheral T lymphocyte count in two HAART-treated PHI cohorts, one of which received hydroxyurea-containing combinations. (
  • A new approach established at the University of Zurich sheds light on the effects of anti-cancer drugs and the defense mechanisms of cancer cells. (
  • Stuart Chambers, Margaret Goodell, and their colleagues investigated the molecular mechanisms underlying aging of stem cells by looking at the gene expression profiles of aging hematopoietic stem cells (HSCs), the precursors of blood cells. (
  • These results lend strong support to the notion that HSCs succumb to the wear and tear of aging, just like other cells, and shed light on the mechanisms of aging. (
  • Though the dominant model attributes the physical effects of aging to an accretion of isolated genetic insults, these results link age-related decline to global mechanisms operating across the genome. (
  • In a trial conducted in type 2 diabetic patients, the drug fenofibrate has reduced retinopathy-related endpoints suggesting a direct effect of the drug on the mechanisms that drive the development of this complication. (
  • CONCLUSIONS To the extent that the DI accurately reflects β-cell function, we observed that both moderate- and vigorous-intensity exercise training improved β-cell function, albeit through distinct mechanisms. (
  • To minimize the negative influence of UVR human skin possesses a number of protective mechanisms including cell-cycle arrest, DNA repair and programmed cell death for situation, when DNA damage cannot be repaired [ 4 , 7 - 14 ]. (
  • This paradoxical effect may reflect a disruption of homeostatic mechanisms that normally act to reduce seizure duration, but only when seizures occur frequently. (
  • Since these procedures are unavoidable in most cases, it's important to understand the mechanisms associated with the potentially toxic effects of anesthetics on the developing brain, and on the adult brain as well," said Shelley Halpain, a professor of biology at UC San Diego and the Sanford Consortium for Regenerative Medicine, who co-headed the investigation. (
  • While overt cell death could certainly be one way to explain any long-lasting neurocognitive consequences of general anesthesia, we hypothesized that there could be other cellular mechanisms that disrupt neural circuits without inducing cell death per se. (
  • Other studies have shown compounds in ginger are able to suppress the growth and spread of cancer cells in breast and colorectal cancers. (
  • Hence, there is still a need for alternative and well-tolerated compounds that exhibit antineoplastic effects in sarcoma cells. (
  • In the LPS-stimulated RAW 264.7 cells 10 μM compounds slightly decreased production of NO and ROS and significantly modulated LPS-induced lipid peroxidation. (
  • An essential property of these compounds is that they must be able to undergo redox reactions in order to shuttle electrons from one electrode to the other during the cell operation. (
  • however, under lactic acidosis, they became less glycolytic but more 'oxidative' ( Figure 1a ), i.e., while the oxygen consumption rate (OCR) was comparable to that of the control cells, the extracellular acidification rate (ECAR) was reduced significantly, leading to a ~5-fold increase of the OCR/ECAR ratio ( Figure 1a ). (
  • a) The effect of lactic acidosis on oxygen consumption rate (OCR), extracellular acidification rate (ECAR) and OCR/ECAR ratio in 4T1 cells. (
  • Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. (
  • A specific epidermal growth factor receptor blocker, AG1478, as well as the Src inhibitor PP2, markedly reduced corticosterone-induced extracellular signal-regulated kinase 1/2 phosphorylation, as did preincubation of cells with the mineralocorticoid receptor antagonist spironolactone. (
  • These effects were dependent on the intact endothelium, mineralocorticoid receptor, and mitogen-activated protein kinase kinase 1/extracellular signal-regulated kinase signaling. (
  • We tested the hypothesis that corticosterone, the physiological glucocorticoid in rats and mice, may exert aldosterone-like effects on early signaling in the vasculature and that these effects are mediated via MR and mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent pathways. (
  • (
  • For example, a cell that's binding the extracellular matrix may bind with one receptor while the matrix is being stretched, and a different receptor when it's not under stress. (
  • Cancer cells also have antigens, but if your immune cells don't have the right receptors, they can't attach to the antigens and help destroy the cancer cells. (
  • The devices -- too small to see without a microscope -- use opposing magnetic and electrophoretic forces to precisely stretch the cells and molecules , holding them in position so that the activity of receptors and other biochemical activity can be studied. (
  • Ribonuclease protection assays employing bovine-specific cRNA probes demonstrated the presence of the messenger RNAs (mRNAs) encoding NGF and its receptors, p75 NTR and trkA, in the thecal compartment of small, medium, and large antral follicles and showed that trkA mRNA is also expressed in granulosa cells. (
  • Because ovulation is preceded by an LH-dependent increase in androgen and progesterone production, the ability of NGF to modify the release of these steroids was determined in freshly plated cells still containing endogenous trkA receptors and in cells undergoing luteinization in culture that were transiently transfected with the trkA-encoding plasmid. (
  • NGF stimulated both androgen and progesterone release in freshly plated thecal cells, but not in luteinizing cells provided with trkA receptors. (
  • Here, we explored the effects of hispolon on human glioblastoma cells U87MG. (
  • In the laboratory, we use human cells or artificial tissues to make refined, accurate measurements of the effects on specific tissues and processes. (
  • Intricate multi-scale interactions among cells, tissues, and organs fundamentally govern human health, which has evolved on Earth under a constant gravitational load of 1 g (9.8 m/s 2 ). (
  • Secondly, stem cells are not simply research material: All cell lines are derived from the tissues of human beings--people who may have an interest in the future of their genetic material and, by law, have certain personal rights that must be respected. (
  • Improving Cryopreservation for a Longer-Lasting Blood Supply (Nov. 17, 2016) - Freezing and reanimating your body is still science fiction, but cryopreserving cells and certain tissues for future use is a reality. (
  • Supporting this notion is that cellular ATP concentration was not significantly disturbed by the decrease of glycolysis ( Figure 1b ) - the intracellular ATP level in cells under lactic acidosis (~0.50 mM) was only marginally lower than that in control cells (~0.64 mM). (
  • Cyclophilins are distributed in various cellular organelles where they facilitate protein folding, act as chaperones, and play a role in cell signaling ( Wang and Heitman, 2005 ). (
  • CAR T cells provide an entirely new level of improved disease response among patients with certain blood cancers and hold promise for more wide-ranging use," said Elizabeth Shpall , M.D., deputy chair and professor of Stem Cell Transplantation and Cellular Therapy at MD Anderson. (
  • TrkA, the nerve growth factor (NGF) tyrosine kinase receptor, is expressed not only in the nervous system, but also in nonneural cells, including discrete cellular subsets of the endocrine and immune system. (
  • This amazing phytochemical destroys cancer cells, reduces inflammation that contributes to cancer, helps to prevent DNA changes that can lead to cancer, and even helps neutralize an enzyme that coverts procarcinogens into active carcinogens - pretty impressive benefits to be gained from a daily helping of humble Brussels sprouts. (
  • Studies show that vitamin C can reduce inflammation, fight free radicals and, in the right dose, it can even kill off cancer cells . (
  • PDE4B and PDE4D subtypes play a pivotal role in inflammation, whereas blocking PDE4D is suspected to cause gastrointestinal side effects. (
  • In vivo, both PDE4-inhibitors decreased transendothelial and transepithelial migration even when administered after inflammation, whereas roflumilast showed a superior effect compared to rolipram on the epithelium. (
  • TY - JOUR T1 - The unrecognized effects of phosphodiesterase 4 on epithelial cells in pulmonary inflammation. (
  • They found that in fetal astrocytes, there are marked signs of inflammation, showing that these cells are the major targets of the virus. (
  • However, he added, "There is evidence that some of the delayed or persistent cognitive effects after surgery are not primarily due to anesthesia itself, but more importantly to brain inflammation resulting from the surgery. (
  • Today there are more treatments than ever to manage advanced cutaneous squamous cell carcinoma (CSCC). (
  • The annual rate of corneal endothelial cell loss in the eyes of patients who had had surgery was compared with those of 42 eyes that had not undergone either procedure. (
  • They also found no relationship between endothelial cell loss and ablation depth or residual bed thickness. (
  • However, tamoxifen may cause severe adverse effects such as increased risk of serious blood clots due to its weak estrogen activity, and the resistance developed during tamoxifen treatment is another clinical challenge [ 14 - 16 ]. (
  • Therefore, there is urgent need to develop novel agents targeting and intervening in ER signaling for ovarian cancer treatment with lower toxic and minimized adverse effects to improve clinical outcomes for this disease. (
  • Stem cells may provide Crohn's disease sufferers relief from a common, potentially dangerous side effect - fistulas - according to the results of a phase 2 clinical trial published in the latest issue of STEM CELLS Translational Medicine. (
  • These viruses are involved in several clinical syndromes and have important immunomodulatory effects. (
  • Ultimately, the clinical implications of these bystander effects need to be determined. (
  • Further in-depth studies with additional cell lines and animal models are warranted to explore the clinical applicability of these agents. (
  • Because the clinical studies haven't been completed, preclinical studies, such as ours, are needed to define the effects of various anesthetics on brain structure and function. (
  • Whether you want to learn about treatment options, get advice on coping with side effects, or have questions about health insurance, we're here to help. (
  • Eliminating the senescent cells in mice prevented the side effects and relapse. (
  • Keep reading to understand how cocaine can trigger brain damage and its other serious side effects. (
  • Most short-term side effects of cocaine wear off within a day or two. (
  • But long term side-effects can be permanent. (
  • Sometimes, the long-term side effects of cocaine use are a sign of brain damage. (
  • But they come with some side effects. (
  • Tell the doctor who treats your cancer about any side effects you have from your treatment. (
  • Meanwhile, here are 12 tips to help you feel better if you're experiencing side effects from your cancer treatment. (
  • Sometimes reducing the amount of medication you take can cut back on side effects. (
  • It can cause several side effects, including skin reactions like a rash or blisters. (
  • Side effects can happen with any type of treatment, but everyone's experience is different. (
  • Some people may have many side effects. (
  • Side effects can happen any time during, immediately after or days to months after stem cell transplant. (
  • Short-term, or acute, side effects generally develop during the first 100 days after a stem cell transplant. (
  • Long-term, or chronic, side effects generally develop 100 or more days after the transplant. (
  • Most side effects go away on their own or can be treated, but some side effects can last a long time or become permanent. (
  • It is hard to say exactly which side effects a child will have, how long they will last and when the child will recover. (
  • Children usually have less severe side effects and will often recover from them faster than adults. (
  • Side effects of stem cell transplant can be very serious or even life-threatening. (
  • They will take measures to prevent side effects and will quickly deal with any side effects that develop. (
  • All types of stem cell transplants share some of the same side effects. (
  • Other side effects are unique to high-dose therapy and stem cell transplant. (
  • The following are the most common side effects that people tend to experience with stem cell transplant. (
  • Tell your healthcare team if you have these side effects or others you think might be from stem cell transplant. (
  • Stem cell shielding appeared to stave off some of these negative side effects. (
  • Other side effects are related to the stem cell transplant. (
  • Find out about side effects that might happen in the first few weeks after a transplant of your own cells. (
  • The side effects you have will depend on the type of high-dose treatment you had before your stem cell transplant. (
  • Most side effects are worst when your blood count is at its lowest. (
  • When your blood count goes up, the side effects will start to improve. (
  • You will have medicines to prevent or reduce side effects. (
  • Always tell your doctor or nurse about any side effects you have. (
  • Stem cell transplants - whether autologous or allogeneic transplants - carry potential side effects and complications. (
  • The following are some potential side effects associated with stem cell transplants in general. (
  • It is important for patients not to lose weight following a transplant, as a healthy weight maintains a proper number of blood cells produced in the body, which can in turn help to minimize side effects. (
  • Keep track of any and all side effects you have after receiving this vaccine. (
  • When you receive a booster dose, you will need to tell the doctor if the previous shot caused any side effects. (
  • However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low. (
  • This is not a complete list of side effects and others may occur. (
  • Call your doctor for medical advice about side effects. (
  • Cardiovascular side effects have included palpitations and hot flush. (
  • Gastrointestinal side effects have included nausea. (
  • Dermatologic side effects have included rash and one case of suspected urticaria pigmentosa. (
  • Musculoskeletal side effects have included myalgia, arthralgia, and monoarthritis. (
  • The most common side effects have included local injection site reactions in up to 45% of patients. (
  • Some side effects may not be reported. (
  • and what side effects would the treatment cause for cancer patients ? (
  • Immune-cell based therapies opening a new frontier for cancer treatment carry unique, potentially lethal side effects that provide a new challenge for oncologists, one addressed by a team led by clinicians at The University of Texas MD Anderson Cancer Center with proposed guidelines for systematically dealing with the toxicities of these drugs. (
  • The review provides specific recommendations for pre-treatment preparation, monitoring of patients during and after CAR T infusion, identifying and staging emerging CRS and CRES, and tailored treatment of those side effects depending upon their severity. (
  • The recently published EORTC 62012 trial which involved 455 patients with locally advanced, unresectable or metastatic high-grade soft tissue sarcomas concluded that an intensified therapy with doxorubicin and ifosfamide is not suitable for palliation of advanced soft tissue sarcomas because of the severe side-effects and should only be used when the specific goal is tumour shrinkage ( 13 ). (
  • Establishment of cancer-specific monoclonal antibodies (CasMabs) for killing cancer cells without side effects against normal cells. (
  • LpMab-2 reacted with podoplanin-expressing cancer cells, but not with normal cells, indicating that LpMab-2 is an anti-podoplanin CasMab without side effects. (
  • Targeting podoplanin, however, may lead to severe side effects because, several physiological functions of podoplanin have been reported recently. (
  • Therefore, LpMab-2 is a CasMab that is expected to be useful for molecular targeting therapy against podoplanin without side effects such as respiratory failure, renal failure, or lymphatic edema. (
  • Time-lapse light microscopy was used to visualize changes in cell morphology during and after cessation of clinorotation. (
  • We also found that both silver and gold nanoparticles induced changes in the morphology of the cell body and processes of U87 cells: again, the effects of silver nanoparticles were more marked than those induced by gold nanoparticles. (
  • They found no significant difference in cell loss or morphology compared to 42 control eyes that had not undergone either procedure. (
  • The morphological changes in these two cell types upon exposing them to the nanoparticles, as observed by bright field light microscopy, were also consistent with the cytotoxicity data. (
  • Furthermore, the effects of drugs on cells produce both chemical and morphological changes, the latter could affect the spectra of cells incubated with drugs. (
  • Atomic force microscopy (AFM) was used to assess morphological and biomechanical changes on fungal cells. (
  • Nevertheless the damages of mitochondrial integrity support the hypothesis that the neurotoxic effect of salsolinol is primarily caused by damaging the endothelial cells associated with a disturbance of blood-brain barrier. (
  • There were no effects on GSH levels or mitochondrial depolarization either. (
  • Graft-versus-host disease (GVHD) might happen after an allogeneic stem cell transplant. (
  • Cells at 75 rpm clinorotation remained viable and were able to re-spread after clinorotation. (
  • The concentration leading to 50% viable cells lost was established as 20 μM and almost complete lethality was observed at 80 μM. (
  • However, patterning and retaining viable single cancer cells on defined sites of the microarray can be challenging. (
  • The viruses may have tropism for many different cell types, including immune cells. (
  • This occurs when the donor's immune cells (T cells) are not recognized by HLA antigens. (
  • and microglia , which are immune cells that can gobble up damaged nerve cells or harmful pathogens. (
  • The research, led by Marco Demaria, PhD, a former postdoc in the Campisi lab, utilized transgenic mice that permit tracking and eliminating senescent cells. (
  • Eliminating senescent cells was sufficient to almost entirely rescue the decline in physical activity in the treated mice,' he said. (
  • When we knocked out the senescent cells the mice returned to normal running. (
  • The healthcare team watches people receiving a stem cell transplant very closely. (
  • here we show that it exerts a significant effect on glucose metabolism in cancer cells by converting a usually dominant Warburg effect to a nonglycolytic phenotype. (
  • Cyclosporin A exerts its immunosuppressive effect by binding to cyclophilin A and the drug-receptor complex inhibits the dephosphorylase activity of calcineurin. (
  • The homozygous form (hemoglobin SS) causes sickle cell anemia and is the most severe kind of sickle cell disease. (
  • Other precautions will also be recommended as required, as it is normal for a patient to experience a high fever at some point during recovery from stem cell transplants. (
  • Anemia is a low red blood cell count and a lower concentration of hemoglobin in blood cells. (
  • Results published in Advances in Bioscience and Biotechnology ​ ​ indicated that incubating human HeLa cells with the commercially available KSM-66 Ashwagandha root extract led to an enhancement of approximately 45% in telomerase activity at a concentration of 10 to 50 micrograms. (
  • Cytometry assays and confocal microscopy imaging showed that Ps d1 causes cell death, in a time and concentration-dependent manner. (
  • 2-EH and DEHP were purchased from Sigma Aldrich (St. Louis, MO) and diluted with dimethyl sulfoxide (DMSO) 1% for the working solutions (0.1% final DMSO concentration to cells) which were kept in sterile conditions and refrigerated until utilized. (
  • We estimated the concentration of free ADP in βHC9 hyperplastic insulin-secreting cells based on the cell diameter and on luminometric measurements of ATP, phosphocreatine, and total creatine. (
  • What remains largely unknown is how immunomodulatory molecules change NPC behavior and whether these effects are due to direct or indirect actions on NPCs. (
  • Immunomodulatory properties of UVR are initiated via a cascade of events beginning with the absorption of UVR energy by endogenous chromophores, including nuclear DNA, trans-urocanic acid, and components of cell membranes [ 3 ]. (