Metabolic Detoxication, Phase I
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
Derived from TELENCEPHALON, cerebrum is composed of a right and a left hemisphere. Each contains an outer cerebral cortex and a subcortical basal ganglia. The cerebrum includes all parts within the skull except the MEDULLA OBLONGATA, the PONS, and the CEREBELLUM. Cerebral functions include sensorimotor, emotional, and intellectual activities.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Monocarboxylic Acid Transporters
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
Proto-Oncogene Proteins c-akt
Free Radical Scavengers
Drugs, Chinese Herbal
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
DNA of kinetoplasts which are specialized MITOCHONDRIA of trypanosomes and related parasitic protozoa within the order KINETOPLASTIDA. Kinetoplast DNA consists of a complex network of numerous catenated rings of two classes; the first being a large number of small DNA duplex rings, called minicircles, approximately 2000 base pairs in length, and the second being several dozen much larger rings, called maxicircles, approximately 37 kb in length.
Kidney Tubular Necrosis, Acute
Oncogene Protein v-akt
Chromatography, High Pressure Liquid
M Phase Cell Cycle Checkpoints
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
Receptor, IGF Type 1
A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.
Cell Cycle Checkpoints
Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM, and divide them equally between two daughter cells. If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or "arrested") until the processes are completed and growth conditions are suitable.
Extracellular Signal-Regulated MAP Kinases
A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.
Transcription Factors, General
Transcription factors that form transcription initiation complexes on DNA, bind to specific DNA-DIRECTED RNA POLYMERASES and are required to initiate transcription. Although their binding may be localized to distinct sequence and structural motifs within the DNA they are considered non-specific with regard to the specific gene being transcribed.
Transcription Factor AP-1
Dose-Response Relationship, Drug
Topoisomerase II Inhibitors
Xenograft Model Antitumor Assays
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Brain Damage, Chronic
A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Mitogen-Activated Protein Kinases
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
JNK Mitogen-Activated Protein Kinases
Proteasome Endopeptidase Complex
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.
p38 Mitogen-Activated Protein Kinases
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
I-kappa B Kinase
Ribosomal Protein S6 Kinases, 70-kDa
A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Reverse Transcriptase Polymerase Chain Reaction
Gene Expression Regulation
Myocardial Reperfusion Injury
Human Umbilical Vein Endothelial Cells
Culture Media, Conditioned
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
Reactive Oxygen Species
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
Antineoplastic Agents, Phytogenic
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Nucleic Acid Denaturation
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
Drug Evaluation, Preclinical
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Gene Expression Regulation, Neoplastic
Magnetic Resonance Spectroscopy
Real-Time Polymerase Chain Reaction
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Vascular Endothelial Growth Factor A
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Oligonucleotide Array Sequence Analysis
Disease Models, Animal
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Gene Expression Profiling
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
It is also used as a mild laxative and has an anti-inflammatory and bactericidal effect . Research with animals suggests ... and luteolin; and coumarin. German chamomile is used in herbal medicine for a sore stomach, skin care, irritable bowel syndrome ... but the flower head can also be used as a whole to make use of the beneficial effect. It can be taken as a herbal tea, two ... antispasmodic, anxiolytic, anti-inflammatory and some antimutagenic and cholesterol-lowering effects for chamomile. As well ...
Histone acetylation and deacetylation
Qiusheng Z, Yuntao Z, Rongliang Z, Dean G, Changling L (July 2005). "Effects of verbascoside and luteolin on oxidative damage ... Acetylation has the effect of changing the overall charge of the histone tail from positive to neutral. Nucleosome formation is ... Glucose availability affects the intracellular pool of acetyl-CoA, a central metabolic intermediate that is also the acetyl ... It has been shown that, even past one replication, expression of genes may still be affected many cell generations later. A ...
... incarnata may increase main effects or side effects of medications listed above. For oral consumption, pregnant or ... Other flavonoids present in P. incarnata include chrysin, apigenin, luteolin, quercetin, kaempferol, and isovitexin. The main ... The effects of oral ingestion of the plant compounds on reproduction or on unborn child have not been tested. P. incarnata ... Ingale, Suvarna P; Kasture, Sanjay B (2017). "Protective Effect of Standardized Extract of Passiflora incarnata Flower in ...
Plasma membrane monoamine transporter
"Luteolin shows antidepressant-like effect by inhibiting and downregulating plasma membrane monoamine transporter (PMAT, Slc29a4 ... These compounds include: Luteolin Cimetidine Decynium-22 Dipyridamole Quinidine Quinine Tryptamine Verapamil Acetylcholine ( ...
... luteolin-8-hexityl monoxyloside), Homoadonivernith, Orientin, Homoorientin, Isoorientin, Luteolin, and Vitexin. There are many ... These glycosides also have a sedative effect and is often prescribed to patients whose hearts are beating irregularly or at an ... Esmail, Al-Snafi Ali (2015). "THERAPEUTIC PROPERTIES OF MEDICINAL PLANTS: A REVIEW OF PLANTS WITH CARDIOVASCULAR EFFECTS (PART ... Esmail, Al-Snafi Ali (2015). "THERAPEUTIC PROPERTIES OF MEDICINAL PLANTS: A REVIEW OF PLANTS WITH CARDIOVASCULAR EFFECTS (PART ...
Luteolin reduces IL-6 production in some neurons. Jones SA, Scheller J, Rose-John S (2011). "Therapeutic strategies for the ... 2013). "Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic diseases: systematic ... New research has found IL-6 to be an anti-inflammatory cytokine with multiple beneficial effects when released by contracting ... Jang S, Kelley KW, Johnson RW (2008). "Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and ...
A study was designed to see the effect of Viola tricolor against neuronlastoma N2a cells. In the end, there was no significant ... Heartsease contains flavonoids (such as quercetin, luteolin and rutin), colorless crystalline compounds proven to be useful in ... Shakespeare mentions it in his play The Taming of the Shrew where Luciento claims he found the effect of love-in-idleness - ... V. tricolor extract had anti-inflammatory effect in acute inflammation induced in male Wistar rats. The plant, especially the ...
槲皮素 - 维基百科，自由的百科全书
The flavonoid luteolin inhibits niacin-induced flush. Brit J Pharmacol. 2008, 153 (7): 1382-87. PMC 2437911. PMID 18223672. doi ... Hirano, T; Kawai, M; Arimitsu, J; Ogawa, M; Kuwahara, Y; Hagihara, K; Shima, Y; Narazaki, M; Ogata, A. Preventative effect of a ... Kawai, M; Hirano, T; Arimitsu, J; Higa, S; Kuwahara, Y; Hagihara, K; Shima, Y; Narazaki, M; Ogata, A. Effect of enzymatically ... Bun SS, Giacometti S, Fanciullino R, Ciccolini J, Bun H, Aubert C. Effect of several compounds on biliary excretion of ...
... have effects on CYP (P450) activity which are enzymes that metabolize most drugs in the body. In organic chemistry ... Common flavones include apigenin (4',5,7-trihydroxyflavone), luteolin (3',4',5,7-tetrahydroxyflavone), tangeritin (4',5,6,7,8- ... Flavones have no proven physiological effects in the human body and no antioxidant food value. Following ingestion and ...
... luteolin, linarin, luteolin 3',4'-dimethylether-7-O-beta-D-glucoside, isoferulic acid, and ethyl rosmarinate. Lobelia chinensis ... is considered mildly toxic due to its adverse effects, including vomiting, heartburn, anxiety, vibrating, eclampsia, increased ...
Affected animals will lose weight, or fail to gain weight; young animals are more affected than old animals. In severe cases ... luteolin) Phenolic acids (e.g. chlorogenic acid, caffeic acid, p-coumaric acid, ferulic acid, p-hydroxybenzoic acid, vanillic ... The organ systems affected by ADRs to St John's Wort and fluoxetine have a similar profile, with the majority of cases ... Some affected animals may accidentally drown. Poor performance of suckling lambs (pigmented and non-pigmented) has been noted, ...
List of Capsicum cultivars
"In Vitro and In Vivo α-Glucosidase and α-Amylase Inhibitory Effects of the Water Extract of Leaves of Pepper (Capcicum Annuum L ... Cultivar Dangjo) and the Active Constituent Luteolin 7-O-Glucoside". Journal of Food Biochemistry. 40 (5): 696-703. doi:10.1111 ...
Although it has received considerable media attention purporting its effects on weight loss, there is liver toxicity associated ... Other compounds identified in the fruit include the polyphenols, luteolin, and kaempferol. In late 2012, a United States ... Adverse events associated with use of such supplements ("side effects") - especially, liver toxicity, as well as ... the evidence for Garcinia cambogia supports no clear effect, while gastrointestinal adverse events were two-fold more common ...
Luteolin, supplement extracted from peanuts that also possesses IGF-1 properties. Drotaverine, used to alleviate renal colic ... Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats; An Torremans, Abdellah ... Shamim MT, Ukena D, Padgett WL, Daly JW (June 1989). "Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono ... Yu MC, Chen JH, Lai CY, Han CY, Ko WC (2009). "Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, ...
Polyphenols found in the species and subspecies: Thymus zygis Apigenin Cirsimaritin Luteolin 6-OH-Luteolin Xanthomicrol Vicenin ... Additionally, there was not any cytotoxic effects shown on eukaryotic mammalian cells at concentrations that are effective ...
O-methylation has an effect on the solubility of flavonoids. O-methylated flavonoids formation implies the presence of specific ... O-methyltransferase Luteolin O-methyltransferase Methylquercetagetin 6-O-methyltransferase 3-methylquercetin 7-O- ...
... is a source of flavonoids and antioxidants, especially luteolin, apigenin, folate, vitamin K, vitamin C, and vitamin A ... Normal food quantities are safe for pregnant women, but consuming excessively large amounts may have uterotonic effects. ...
The predominant active constituents are nerol acetate, curcumin, pinene, limonene, kaempherol, quercetin, luteolin, linalool, ... stems and foliage which have confirmed that it has an inhibitory effect on some bacteria and viruses. Due to the intense ...
Barbaro, B; Toietta, G; Maggio, R; Arciello, M; Tarocchi, M; Galli, A; Balsano, C (2014). "Effects of the Olive-Derived ... including luteolin, rutin, caffeic acid, catechin and apigenin. Elenolic acid is a component of olive oil and olive leaf ... However, scientific evidence for health effects of using olive leaf extract has been deemed insufficient by the European Food ... the leaf and its extracts remain under preliminary research with unknown effects on human health. The silvery green leaves are ...
... has shown to have anti-proliferative effects on many types of cancer cells by inhibiting cancer cell lipogenesis. By ... An, Sang Mi; Kim, Hyo Jung; Kim, Jung-Eun; Boo, Yong Chool (2008). "Flavonoids, taxifolin and luteolin attenuate cellular ... There is also a strong correlation (with a correlation coefficient of 0.93) between the antiproliferative effects of taxifolin ... Lee, Saet Byoul; Cha, Kwang Hyun; Selenge, Dangaa; Solongo, Amgalan; Nho, Chu Won (2007). "The Chemopreventive Effect of ...
Despite the presence of coumarin, as chamomile's effect on the coagulation system has not yet been studied, it is unknown if a ... The main constituents of chamomile flowers are polyphenol compounds, including apigenin, quercetin, patuletin, and luteolin. ... There is insufficient scientific evidence that consuming chamomile in foods or beverages has any effect on health. The word " ... there is insufficient clinical evidence about its potential for affecting nursing infants. The chamomile plant is known to be ...
Nausea, vomiting, and related general gastrointestinal side effects are the most commonly implicated side effects of PDE4 ... Yu, M. C.; Chen, J. H.; Lai, C. Y.; Han, C. Y.; Ko, W. C. (2009). "Luteolin, a non-selective competitive inhibitor of ... Other possible side effects include respiratory and urinary tract infections, which have been discovered from the clinical use ... Luteolin, supplement extracted from peanuts that also possesses IGF-1 properties. Mesembrenone, an alkaloid from the herb ...
recently described the up-regulation of Smr15C2 under cold shock stress, while no effects of a temperature downshift were ... and luteolin-MM broth and endosymbiotic bacteria (i.e. mature symbiotic alfalfa nodules), high salt stress, oxidative stress ...
Keith W. Kelley
Cytokine effects on behavior. In R. Ader, D.L. Felten and N. Cohen (Eds.) Psychoneuroimmunology. Third Edition. Academic Press ... Luteolin reduces interleukin-6 production in microglia by inhibiting c-Jun N-terminal kinase phosphorylation and activation of ... In early 2000s, Kelley was asked to share his new concept of how TNF affects neurons and other cells for Trends in Neuroscience ... The pituitary gland is required for protection against lethal effects of Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 88: ...
Its effects against the proliferation of viruses is thought to be a consequence of myricetin's ability to inhibit the proper ... Myricetin is structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same functions as ... Although myricetin has not been concluded to have more than a neutral effect on humans, it has been used as a form of ... This insulinomimetic effect is hypothesized to be a consequence of myricetin's either direct or indirect interaction with GLUT4 ...
Taksifolin - Wikipedija, prosta enciklopedija
6.^ An, Sang Mi; Kim, Hyo Jung; Kim, Jung-Eun; Boo, Yong Chool (2008). "Flavonoids, taxifolin and luteolin attenuate cellular ... 2.^ Lee, Saet Byoul; Cha, Kwang Hyun; Selenge, Dangaa; Solongo, Amgalan; Nho, Chu Won (2007). "The Chemopreventive Effect of ... 1.^ Makena, Patrudu S.; Pierce, Samuel C.; Chung, King-Thom; Sinclair, Scott E. (2009). "Comparative mutagenic effects of ...
Girl with a Pearl Earring
This effect was produced by applying a thin transparent layer of paint-a glaze-over the black background seen now. However, the ... The dark background of the painting contains bone black, weld (luteolin, reseda luteola), chalk, small amounts of red ochre, ...
The plant is rich in luteolin, a flavonoid which produces a bright yellow dye. The yellow could be mixed with the blue from ... Any ecological, medical or health effects of barbarin and resedine are poorly understood. Ramses Wissa Wassef Art Centre annual ...
The antiviral effects of naringenin are currently under clinical investigation. Reports of antiviral effects on polioviruses, ... Gutiérrez-Venegas, Gloria; Kawasaki-Cárdenas, Perla; Rita Arroyo-Cruz, Santa; Maldonado-Frías, Silvia (2006-07-10). "Luteolin ... PMID 8485024.Ueng YF, Chang YL, Oda Y, Park SS, Liao JF, Lin MF, Chen CF (1999). "In vitro and in vivo effects of naringin on ... Naringenin also produces BDNF-dependent antidepressant-like effects in mice.Yi LT, Liu BB, Li J, Luo L, Liu Q, Geng D, Tang Y, ...
GABAA receptor positive allosteric modulator
Selye H (1 January 1941). "Anesthetic Effect of Steroid Hormones". Experimental Biology and Medicine. 46 (1): 116-121. doi: ... GABAA PAMs increase the effect of GABA by making the channel open more frequently or for longer periods. However, they have no ... S(-) form of barbiturate have shown more depressant activity while the R(+) isomers have an excitatory effect. ... Preclinical studies have shown that benzodiazepines can be effective in reducing the effect of strokes for up to three days ...
Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R, Ren H, Li ZW, Wong JT, Xue H (2002). "Anxiolytic effect of wogonin, a ... "GABA A receptor subtype selectivity underlying selective anxiolytic effect of baicalin". Neuropharmacology. 55 (7): 1231-7. ...
Since the dose margin between the anticonvulsant and hypnotic effect is small, paraldehyde treatment usually results in sleep. ... though there is no known mechanism for this function beyond the placebo effect). ...
Propolisz - Wikipédia
R. Padmavathi u. a.: Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12 ... A sebgyógyítás képességét az apigenin és luteolin jelenlétével magyarázzák. Az állatkísérletek szerint a daganatok ... R. Padmavathi et al.: Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12 ... június 1.). „The effect of bee propolis on recurrent aphthous stomatitis: a pilot study". Clin Oral Investig. 11 (2), 143-7. o ...
Among these, cough is the most common adverse effect. Hyperkalemia can occur, especially if used with other drugs which elevate ... Ajayi AA, Campbell BC, Rubin PC, Reid JL (November 1985). "Effect of naloxone on the actions of captopril". Clinical ...
Serotonin-norepinephrine reuptake inhibitor
A phenyl group in substituent R6 showed effect on norepinephrine transporters. Substituent groups in R6 and R7 with allylic ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ... This effect of SNRIs results in increased dopamine neurotransmission, in addition to the increases in serotonin and ... Beesdo K, Hartford J, Russell J, Spann M, Ball S, Wittchen HU (December 2009). "The short- and long-term effect of duloxetine ...
Basáñez MG, Pion SD, Boakes E, Filipe JA, Churcher TS, Boussinesq M (May 2008). "Effect of single-dose ivermectin on Onchocerca ... For dogs, the insecticide spinosad may have the effect of increasing the potency of ivermectin. ... "Effect of a single standard dose (150-200 μg/kg) of ivermectin on microfilaremia: systematic review and meta-analysis". Open ...
اتیلن - ویکیپدیا، دانشنامهٔ آزاد
... went into her trance-like state as an effect of ethylene rising from ground faults. ... "Effect of ethylene on flower abscission: a survey". Annals of Botany. 89 (6): 689-693. doi:10.1093/aob/mcf124. PMC 4233834 ... synthesis is less effective for reducing post-harvest losses since ethylene from other sources can still have an effect. By ...
I found the effect of love in idleness;. And now in plainness do confess to thee,. That art to me as secret and as dear. As ... luteolin and rutin. Various carotenoids have been isolated from the drug : violaxanthin, antheraxanthin, lutein, zeaxanthin and ... Shakespeare mentions it in his play The Taming of the Shrew where Luciento claims he found the effect of love-in-idleness - ... The study is designed to see the effect of Viola tricolor against neuronlastoma N2a cells. In the end, there was no significant ...
Adverse effect incidence. Very common (,10% incidence) adverse effects include: ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
Okuma T, Kishimoto A (February 1998). "A history of investigation on the mood stabilizing effect of carbamazepine in Japan". ... this unusual side effect is usually not noticed by most people, and disappears after the person stops taking carbamazepine. ... rare case reports of an auditory side effect have been made, whereby patients perceive sounds about a semitone lower than ...
Effect of a new series of bicyclic compounds with potential thymoleptic properties on the reserpine-resistant uptake mechanism ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
Food effect on the overall bioavailability of armodafinil is considered minimal; however, time to reach peak concentration may ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
In concentrations of 3-5% in air, an anesthetic effect can slowly be achieved in 15-20 minutes of breathing approximately 15-20 ...
Hetzler RK, Knowlton RG, Somani SM, Brown DD, Perkins RM (January 1990). "Effect of paraxanthine on FFA mobilization after ...
1993). "Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory ... Luteolin • Mesembrin • Piklamilast • Roflumilast • Rolipram • Ro20-1724 • RPL-554 • YM-976 ...
Ben Kimmelman, Captain, 28th Infantry: The assumptions were that this would have some kind of cathartic effect, the sodium ...
When assayed in mice, repeated exposure to MDPV causes not only an anxiogenic effect but also increased aggressive behaviour, a ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ... On October 17, 2011, an Ohio law banning synthetic drugs took effect barring selling and/or possession of "any material, ... compound, mixture, or preparation that contains any quantity of the following substances having a stimulant effect on the ...
This adverse effect is not unique to zolpidem but also occurs with other hypnotic drugs. Caution should be exercised by motor ... Like zaleplon, zolpidem may increase slow wave sleep but cause no effect on stage 2 sleep. A meta-analysis that compared ... Perrais D, Ropert N (January 1999). "Effect of zolpidem on miniature IPSCs and occupancy of postsynaptic GABAA receptors in ... Zolpidem has also been studied in persistent vegetative states with unclear effect. A 2017 systematic review concluded that ...
... a new 5-HT reuptake blocker with particular emphasis on the side-effect profile of the 5-HT-uptake inhibiting drugs". ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
The effect of dihydrotestosterone (androstanolone) on clinical course and hormonal excretion". Cancer. 8 (1): 82-6. doi:10.1002 ... The effect of dihydrotestosterone (Androstanolone) on clinical course and hormonal excretion". Cancer. 8 (1): 82-86. doi: ... Kennedy BJ (1955). "The effect of stanolone in the treatment of advanced breast cancer". Cancer. 8 (3): 488-97. doi:10.1002/ ... Androstanolone esters act as prodrugs of androstanolone in the body and have a long-lasting depot effect when given via ...
... α-Pinene in particular is thought to reduce the memory deficits commonly reported as a side-effect of THC consumption. It ...
central nervous system stimulatory effect mainly on the medullary respiratory center.. The main therapeutic uses of ... Some lipid-based formulations of theophylline can result in toxic theophylline levels when taken with fatty meals, an effect ... an effect mediated via histone deacetylase-2 (HDAC2). Once deacetylated, DNA is repackaged so that the promoter regions of ...
... but does not produce amnesia and blocks the amnestic effect of diazepam, reflecting its different subtype affinity compared to ...
... has no effect on intracellular calcium stores, but rather, does not allow the entry of Ca2+ after intracellular stores ... Studies of the effect of several alkaloids in mice, including glaucine, demonstrate anticonvulsant and antinociceptive ... and a hallucinogenic effect characterised by colourful visual images, and has been detected as a novel psychoactive drug. ...
... and no evidence for its effect on testosterone levels. In 2016, the US Food and Drug Administration did not recommend ... there was no evidence to support any effect of oral chrysin on testosterone levels, or an any disease-modifying activity ...
Luteolin, Apigenin, Tangeritin Flavonol. or. 3-hydroxyflavone 3-hydroxy-2-phenylchromen-4-one ✓ ✗ Quercetin, Kaempferol, ... However, population-based studies have failed to show a strong beneficial effect, which might be due to the considerably ...
Regular users build up a physical tolerance, requiring larger doses for the same effect. ...
Improve Memory: Two Veggies Are the Best for Your Memory
A diet rich in the plant compound luteolin could reduce age-related inflammation in the brain, according to a new study in the ... Now, older studies have shown that luteolin has anti-inflammatory effects in the body. However, this new look is the first to ... Luteolin was preventing inflammation. Later, they tested this idea on mice, fed either a control diet or a luteolin- ... Starting to forget things? Remember this word: "luteolin.". A diet rich in the plant compound luteolin could reduce age-related ...
Ultrasonic Extraction of Olive Leaf Extract - Hielscher Ultrasound Technology
Sari, Hafize Ayla; Ekinci, Raci (2017): The effect of ultrasound application and addition of leaves in the malaxation of olive ... The composition of phenolic compounds in olive leaves includes oleurosides (oleuropein, verbascoside), flavones (luteolin, ... The extreme environmental conditions in the "hot spot" zone of the ultrasonic cavitation have various effects on the plant ... Olive leaf extracts have anti-inflammatory effects and have been found to improve chronic diseases (e.g. diabetes, arthritis), ...
17 Best Supplements for Immune System in Malaysia during this Coronavirus Pandemic
Studies have shown that luteolin possesses beneficial neuroprotective effects both in vitro and in vivo. It also has ... 7. Luteolin. Luteolin is a common flavonoid abundantly present in several plant products, including broccoli, pepper, thyme, ... The COVID-19 ( CO stands for corona, VI for virus, and D for disease ) pandemic has affected the entire world. With the ... above also studied other compounds and at number 3 on the list as those that has the potential to block the virus was Luteolin. ...
TEAOLOGY | Lychee Jasmine Chunmee | Green Tea - Teaology
Luteolin has anti-oxidant and anti-inflammatory effects which can reduce the effects of multiple sclerosis, Luteolin has anti- ... Luteolin:. Luteolin interferes with nearly all types of cancer cells.. It inhibits the growth of new blood vessels in tumors, ... Luteolin is also an anti-inflammatory, antioxidant, prevents UVB-induced skin aging, luteolin can be used in the prevention and ... oxidant and anti-inflammatory effects which can reduce the effects of multiple sclerosis ...
Anti-Addiction Herbs and Plant Medicines | Alive-N-Healthy
Luteolin. Luteolin is a flavone with anti-depressant effects that works in part by impacting GABA levels in the brain. It also ... The effects caused by Valerian root can take 3-4 weeks to become noticeable. This herb has an effect on serotonin levels and ... At lower doses, the anti-addiction effects are less evident and at higher doses, the effects of Huperizine A may cause negative ... Valerian has an effect on the autonomic nervous system that causes it to not only reduce digestive cramping, but also spasms in ...
Stress Solution, Part 1 - Nutrition for POTS, MCAS, dysautonomia, autoimmunity and related conditions
... not only because it can affect your appetite and will-power, but also because it can raise your blood sugar. How? Adrenaline. ... Quercetin and Luteolin as Endocrine Disruptors January 21, 2021 * How psychological stress affects mast cells October 31, 2020 ... As you may have experienced, stress makes it harder to lose weight-not only because it can affect your appetite and will-power ...
Trade fun for food - Nutrition for POTS, MCAS, dysautonomia, autoimmunity and related conditions
Limit seafood to 12oz per week - Nutrition for POTS, MCAS, dysautonomia, autoimmunity and related conditions
Why summer is the easiest time to give up sugar - Nutrition for POTS, MCAS, dysautonomia, autoimmunity and related conditions
Testo Lab Pro Review UK - Complete and Updated for 2021
Luteolin has been shown to have pro-testosterone effects by reducing enzyme activities that convert testosterone to other ... Side effects. The high quality ingredients in Testo Lab Pro gives some reassurance that side effects can be minimal but it ... Unwanted side effects could happen if you body doesnt react well to one of the ingredients so we always recommend you discuss ... Luteolin from Orange extract. This is a rare ingredient to find in a testosterone booster. ...
Skin Anti-Aging Support - Geres Dengle®
Natural Protection from Apigenin Luteolin Curcumin and Ginger o Ultraviolet Radiation and Skin Aging (Photoaging) The most ... Anti-carcinogenic effects of the flavonoid luteolin. Molecules. 2008 Oct 22;13(10):2628-51.. (15) Arbiser JL, et al. Fisetin: a ... Luteolin and Apigenin Luteolin and apigenin have been shown as skin protectors from harmful UV radiation in many research ... In another study involving mice and cell cultures, luteolin inhibited the incidence of UVB-induced skin cancer.(2). • Luteolin ...
Lysosomal Activity Declines With Aging - Fight Aging!
Blog de dajunkraso - Dominick Taber Blog - Skyrock.com
Hwang and his colleagues new mechanistic new mechanistic explanation of how luteolin exerts its anti-inflammatory effects offer ... Of the six compounds luteolin was the most effective inhibitor of TBK1. Luteolin is already known to have anti-inflammatory ... Haiti, and how to to provide provide a long term side effects of kamagra gold and only deal.. Kamagra Oral Jelly Detail ... Pay with paypal method side effects yahoo si te perdoret kamagra u apotekama bih cheap polo uk.. Kamagra oral jelly is a ...
7 Vegan Foods That Are Good for Your Teeth | Divine Ghawdess Naturals
However, have you ever considered what effects your diet has on various aspects of your health? ... This effect occurs because apples contain a ton of fiber. Fiber causes you to chew more thoroughly to break it down. During ... Celery contains a substance called luteolin, which calms this inflammation. 2. Apples. Maybe youve snacked on a McIntosh and ... However, have you ever considered what effects your diet has on various aspects of your health? One place where vegan eating ...
Organic intensive anti-ageing face serum - Less is More
The natural treatment can also be applied by massaging the temples, for a soothing and refreshing effect. ... Edelweiss - very rich in antioxidants and contains chlorogenic acid and luteolin ; exceptional protecting, repairing and ... It has anti-oxidant ; antibacterial, calming and resistance-strengthening effects, protecting and soothing the skin ...
Benefits of Artichoke Extract for High Blood Pressure - NatureWord
Luteolin is a flavone antioxidant in artichoke and artichoke extract, and a range of other plants with medicinal properties. ... Metabolic management (anti-diabetic effects). Another way artichoke extract is good for high blood pressure is via metabolic ... Research shows luteolin activates enzymatic reactions that trigger the production of nitric oxide. Nitric oxide acts as a cell ... Artichoke is a prebiotic with positive effects on beneficial gut bacteria. Research shows daily consumption of a very-long- ...
dandelion seeds benefits
In herbal terms, dandelion root is considered to be both a choleretic herb (affects the liver) and a cholagogue (affects the ... Furthermore, they are rich in antioxidants like vitamin-C and Luteolin, which supports and maintains bone health at all ages. ... Use it on face skin affected with acne. As kids, we used to pick them and make a wish for good luck as we blew the dandelion ... They are also rich in antioxidants, which helps reduce the effects of ageing. It can even remove cystic acne, and share same ...
A network pharmacology study of reduning injection for the treatment of coronavirus disease-19 Wu J, Ruan DD, Fu TF, Yuan J -...
... luteolin, stigmasterol, beta-sitosterol, and kaempferol, exert a regulatory effect on 2019-nCoV [Figure 1], [Figure 2] and [ ... effects and inhibits coronavirus 3a channel protein to inhibit virus release. Luteolin can downregulate the expression of ... luteolin, and kaempferol being the major three. The components possibly affect 151 signaling pathways, including AGE-RAGE, TNF ... subsequently increasing their cytolytic effect; IL-4 is a multi-effect cytokine that prolongs the lifespan of T- and B-cells ...
Effects of Manuka Honey Combined with -Cyclodextrin on Bone Metabolism and Caecal Bacterial Contents in Ovariectomized Mice
However, there have been few studies regarding the effects of manuka honey on bone metabolism and gut microflora. This study ... These results suggest that the MHCP expressed prebiotic effects, which might reduce bone resorption in OVX mice. ... Honey has antimicrobial, antitumor, antioxidant, and anti-inflammatory effects. ... investigated the effects of manuka honey combined with α-cyclodextrin, Manuka Honey with CyclopowerTM (MHCP) on bone metabolism ...
Diabetes And Watermelon | E-Witch
... affect affected after again aimed alabama alternative ambari america american anchor angeles animals ankle anticipated ... This is because the leaves have excessive ranges of bioactive compounds corresponding to apigenin, luteolin, and kaempferol. ... A 2019 examine suggested that celery leaves affect cytokines, which are immune system messenger molecules responsible for anti- ... effect effective efficient eighty electrolytes element elements eleven ellen elliptical ellipticals embiids employers energy ...
The Effect of Salvia Absconditiflora extract on the gene expression of GSTO1 and GSTZ1 in MCF-7 and MDA-MB-231 cells
LC-MS/MS analyses revealed the presence and quantities of caffeic acid, luteolin rutin and coumaric acid. Cytotoxic effects of ... The Effect of Salvia Absconditiflora extract on the gene expression of GSTO1 and GSTZ1 in MCF-7 and MDA-MB-231 cells. Download ... Effects of S.absconditiflora water extract on the expression of glutathione-S-transferases (GSTs) in MCF-7 and MDA-MB-231 cells ... N. D. Hisarlı, "The Effect of Salvia Absconditiflora extract on the gene expression of GSTO1 and GSTZ1 in MCF-7 and MDA-MB-231 ...
The Chia Co Australia | Latest and Greatest: Celery Juice
Endometriosis Treatment Report
Ameliorative effects of luteolin, a therapeutic phytochemical, against endometriosis progression in vitro and in vivo Mar 3, ... Effect of herb-partitioned moxibustion (HPM) on pain and quality of life in women with endometriosis: a protocol for a ... The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory ... Effects of Sulawesi Propolis Extract on Lesion Growth, Apoptotic and Inflammatory Activity of the Rat Endometriosis Tissue May ...
Buy Thyme Tea: Benefits, How to Make, Side Effects | Herbal Teas Online
Some studies have shown that thyme exhibits anti-inflammatory activity due to the presence of rosemarinic acid and luteolin. ... Soothing effects on the nervous system The herbal infusion may help in the management of depression, anxiety, and mental ... Certain respiratory illnesses caused by infections such as bronchitis are treatable due to its antibacterial effects. Improves ... honey for taste Safety and Precautions Side effects Having it as a part of a regular diet does not lead to any adverse effects ...
Erotisk massasje bergen erotisk treff - Dynomite
Agrimonia eupatoria / Agrimonie - Kruidwis
Flavonoids Apigenin, luteolin, luteolin-7-glucoside, quercetin, quercitrin, kaempferol and glycosides . (3) ... A hypotensive effect in anaesthetised cats has been documented for an agrimony extract given by intravenous injection ; blood ... 16 Hsu F-L, Cheng J-T. Investigation in rats of the antihyperglycaemic effect of plant extracts used in Taiwan for the ... Silicic acid, traces of essential oil, and the flavonoids luteolin and apigenin 7-O-β-D-glucosides are present. 4 Organic acids ...
Effects Of Filtration Process And Storage Time On The Chemical Changes And Sensory Properties Of Olive Oil Extracted From...
Luteolin was the most abundant phenolic compound and its concentration decreased from 268.65 +/- 5.428 to 93.57 +/- 0.541 ppm ... It seemed effect of filtration was more obvious on total phenolic contents. This study was good practice for producing premium ... Effects Of Filtration Process And Storage Time On The Chemical Changes And Sensory Properties Of Olive Oil Extracted From ... Filtration had no detectable effect on fatty acid profile. Filtered sample had higher total phenols (407.64 +/- 4.051 ppm) and ...
jack stauber buttercup meme
Flavonoids (hesperidin, naringin, luteolin, and ferulic acid) are also nice active compounds with possible antioxidant, anti- ... Variety of possible effects is smart, but even if everything is right, it is usually as! No introduction as one of those things ... Some of them (namely hesperidin and luteolin) might even have skin brightening activity by inhibiting tyrosinase, the famous ... "time-release AHA effect" and reduces the irritation associated with AHAs. The three of them is called AquaCell and is claimed ...
Full Spectrum Oil vs CBD Isolate - A Fact-Based Report - Eating With Wisdom
Most cannabinoids affect our neurochemistry by activating neurotransmitter receptors, and by doing so they can calm down our ... The most bioactive cannabis phenols are flavonoids that are found in other edible plants, including apigenin, luteolin, ... With over 100 known cannabinoids contained in cannabis, these effects are far-reaching, and the science is so new that we are ... As with terpenes, phenols often affect us through their aromas. Once they have been absorbed by our bodies, they begin to fight ...
Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. European Journal of Pharmacology. Volume ... Látka jménem luteolin izolovaná ze šišáku bajkalského zároveň zásadním způsobem ovlivňuje apoptózu neboli programovanou ... Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. European Journal of Pharmacology. Volume ... Hepatoprotective effect of the fractions of Ban-zhi-lian on experimental liver injuries in rats. J Ethnopharmacol. 1997 May;56( ...
FlavonoidsSuggest that luteolinPotential of luteolinInhibitCell proliferationInhibitsApoptosisMechanism of luteolinAntioxidantInhibitory effectInhibitionFlavoneAnticancerPeanut Shell Extract LuteolinCeleryFlavonoid foundHumansParsleyShow that luteolinRich in luteolinApigenin and luteolinProperties of luteolinQuercetin and LuteolinProliferationInflammationKaempferolDietary luteolinAngiogenesisVitroMechanismsCompoundsDisordersEndometrial cancerCommon flavonoidCellsProteinRutinExtractsTumorNeurodegenerativeSignalling pathwayEfficacyMoleculesAssayBeneficialProtective EffectsNeuronsReactive oxygenStudyExertsResultsOxidativeEstrogenReducesAntitumor effectsPharmacological effectsMigrationMorbidity and mortaPlants
- Here, we evaluated the effects of eight flavonoids on the tumour cell proliferation, cellular protein phosphorylation, and matrix metalloproteinase (MMPs) secretion. (nih.gov)
- 2. Of the flavonoids examined, luteolin (Lu) and quercetin (Qu) were the two most potent agents, and significantly inhibited A431 cell proliferation with IC50 values of 19 and 21 micronM, respectively. (nih.gov)
- 7. Examination of the relationship between the chemical structure and inhibitory effects of eight flavonoids reveal that the double bond between C2 and C3 in ring C and the OH groups on C3' and C4' in ring B are critical for the biological activities. (nih.gov)
- Certain flavonoids, such as luteolin, have anti-oxidant and anti-inflammatory effects, including inhibition of activated peripheral blood leukocytes from MS patients. (longevityunlocked.com)
- Moreover, luteolin and structurally similar flavonoids can inhibit experimental allergic allergic encephalomyelitis (EAE). (longevityunlocked.com)
- Flavonoids such as Quercetin and Luteolin have potent anti-oxidant and anti-inflammatory activity. (longevityunlocked.com)
- Koosha S, Alshawsh MA, Looi CY, Seyedan A, Mohamed Z. An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer. (medsci.org)
- We also describe the signaling pathways affected by flavonoids that have been found to be involved in CRC. (medsci.org)
- Anti-inflammatory effects of flavonoids in neurodegenerative disorders. (semanticscholar.org)
- Figure 1 shows the molecular structure of the flavonoids employed: luteolin, quercetin, genistein and quercetagetin. (biomedcentral.com)
- We show that two flavonoids, luteolin and quercetin, are promiscuous endocrine disruptors. (springer.com)
- We also show an alternative orientation of luteolin within the TBS which could represent a general mode of binding of flavonoids to TTR and is of importance concerning the future design of tetramer stabilizing drugs. (sigmaaldrich.com)
- Luteolin is a very typical kind of natural flavonoid and belongs to weak acidic tetrahydroxy flavonoids. (chemicalbook.com)
- In this review, we discuss host and microbiota-mediated metabolism of flavonoids and the potential mechanisms by which flavonoids can exert protective effects against colon tumorigenesis, including regulation of signaling pathways involved in apoptosis, cellular proliferation, and inflammation and modulation of the gut microbiome. (mdpi.com)
- Like other flavonoids, luteolin as shown in Figure 1 (3, 4, 5, 7- tetrahydroxyflavone), is often found in the various vegetables and fruit materials in the form of glycosides and has contributed as the antioxidant property in different diseases. (alliedacademies.org)
- Luteolin is one of the few flavonoids that is not readily absorbed by the body. (naturalpedia.com)
- His study explored the effects of the flavonoids luteolin and querceti. (bio-medicine.org)
- Flavonoids tested in the study affected the endocrine system in ways that in one case promoted cancer and in another repressed it. (bio-medicine.org)
- His study explored the effects of the flavonoids luteolin and quercetin on cell models of breast and endometrial cancer. (bio-medicine.org)
- Detrimental effects of flavonoids are not without precedent. (bio-medicine.org)
- Luteolin shown in Figure 1 is one of the important dietary flavonoids which are commonly present in various fruits and vegetables. (alliedacademies.org)
- Here, we report that flavonoids have a beneficial effect in acute and chronic experimental allergic encephalomyelitis (EAE). (rupress.org)
- Both in vitro and in vivo studies report that flavonoids and their metal ion complexes exert pleiotropic effects on tumor promotion and progression. (intechopen.com)
- The credit goes to the flavonoids quercetin, genistein, and luteolin. (naturalpedia.com)
- Effects of Luteolin and Other Flavonoids on IgE-mediated Allergic Reactions. (nii.ac.jp)
- De Matouschek 1991 The flavonoids luteolin and 6-C-glucoside have also been isolated. (drugs.com)
- It contains antioxidants from flavonoids, such as quercetin and luteolin, and chamazulene(an essential oil). (selfgrowth.com)
- When measured against 27 other flavonoids, luteolin provided the best DNA protection. (makemeheal.com)
- Antitussive properties contains flavonoids, such as luteolin, pectin fiber furthermore having demulcent and antitussive effect. (botanical-online.com)
- some articles mention that flavonoids contained in the fruits of cactus have protective effect on the brain, being a suitable food for memory and prevent degenerative diseases like Alzheimer's . (botanical-online.com)
- Celery contains the flavonoids luteolin and apigenin, which researchers from the University of Illinois believe could have pancreatic cancer-killing capabilities. (healthcentral.com)
- Some recent studies suggest flavonoids in passionflower are primarily responsible for its relaxing effects however, more research is needed. (nutrametrix.com)
Suggest that luteolin6
- Our results suggest that luteolin could be a potent anti-angiogenic agent for retinal neovascularization, which is related to anti-oxidative activity to block ROS production and to subsequently suppress VEGF expression and the pro-angiogenic effect of VEGF. (arvojournals.org)
- The present findings suggest that luteolin ameliorates D-GalN/LPS-induced liver injury and that this protection is likely due to inhibition of the extrinsic and intrinsic apoptotic pathways. (sparrho.com)
- In conclusion, the results suggest that luteolin can inhibit the proliferation of breast cancer cells , and suppress the expression of Bcl-2. (bvsalud.org)
- although this does not in any way suggest that luteolin does not offer any health benefits. (naturalpedia.com)
- These results suggest that luteolin is a genuinely active constituent which is accountable for the oral effects of perilla. (go.jp)
- Furthermore, studies on animals suggest that luteolin could enhance the potency of chemotherapy drugs that act on cancer cells while reducing the toxic effects of these drugs on the body. (medicalnewstoday.com)
Potential of luteolin4
- The present investigation shows the potential of luteolin as a stabilizer of TTR in vivo. (sigmaaldrich.com)
- The antioxidant potential of luteolin was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. (nih.gov)
- Owing to the excellent anti-inflammatory, anticancer, antioxidant and free radical scavenging potential of luteolin, we assume that it might possess the protective effect against the DCM. (alliedacademies.org)
- The promising anticancer potential of luteolin can be effectively utilized in future for anticancer drug development. (alliedacademies.org)
- 5. The addition of EGF only marginally diminished the inhibitory effect of luteolin and quercetin on the growth rate of A431 cells, treatment of cellular proteins with EGF and luteolin or quercetin greatly reduced protein phosphorylation, indicating Lu and Qu may act effectively to inhibit a wide range of protein kinases, including EGFR tyrosine kinase. (nih.gov)
- Innovative ways of delivering select flavonoid combinations would be required to assure sufficient plasma levels, especially if luteolin can inhibit brain inflammation. (longevityunlocked.com)
- By using a high concentration of luteolin in the blood, we were better able to inhibit the growth of cancer cells. (redorbit.com)
- Preliminary studies have found that luteolin can inhibit the apoptosis of the angiogenesis induced cell, affect the tumor growth in animal models, reduce the tumor growth and also improve the cytotoxicity of certain anti-cancer drugs on the tumor cell, indicating that luteolin could be potential cancer chemo-preventive drugs and chemotherapy drugs. (chemicalbook.com)
- Luteolin has been found to inhibit CRC cells proliferation, induce cells apoptosis and cell cycle perturbation ( 13 - 15 ). (spandidos-publications.com)
- Liu et al also reported that luteolin was able to inhibit CRC cells epithelial to mesenchymal transition by suppressing CREB1 expression ( 16 ). (spandidos-publications.com)
- Previously, we described the flavone luteolin and especially the flavonol quercetin as being potent antioxidants that inhibit myelin phagocytosis by macrophages ( 7 ). (rupress.org)
- It was reported that luteolin, extracted from Chinese herbs, could potently inhibit influenza virus replication in vitro. (springermedizin.de)
- One favorable mechanism of luteolin is its ability to inhibit oxidative damage to cellular DNA. (makemeheal.com)
- The luteolin significant inhibited RPMI-8226 cell proliferation in a dose-dependent manner. (greenmedinfo.com)
- 8. This study demonstrates that the inhibitory effects of Lu and Qu, and the stimulatory effects of EGF, on tumour cell proliferation, cellular protein phosphorylation, and MMP secretion may be mediated at least partly through EGFR. (nih.gov)
- Luteolin effectively inhibited cell proliferation and induced apoptosis in HER2-overexpressing cancer cells. (aacrjournals.org)
- We have also measured how different concentrations of luteolin effects on cell proliferation of HepG2 over 48 h of window. (alliedacademies.org)
- Luteolin Decreases EGFR-Mediated Cell Proliferation and Induces Apoptosis in Glioblastoma Cell Lines. (cedarville.edu)
- Luteolin inhibits the proliferation of RPMI-8226 cells. (greenmedinfo.com)
- Luteolin inhibits the proliferation of RPMI-8226 cells by inducing the pathways of both apoptosis and autophagy, moreover the actions of apoptosis and autophagy are interactive or/and promotive each other. (greenmedinfo.com)
- Luteolin also inhibits mast cells, as well as mast cell-dependent T cell activation, recently implicated in MS pathogenesis. (longevityunlocked.com)
- Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell dependent stimulation of Jurkat T cells. (longevityunlocked.com)
- Luteolin inhibits the invasion,migration and adhesion ability of human hepatocelluar carcinoma HepG2 cells .The mechanism may be related to the regulatory effects of luteolin on epithelial-mesenchymal transition . (bvsalud.org)
- We believe dietary luteolin accesses the brain and inhibits or reduces activation of microglial cells and the inflammatory cytokines they produce. (lifeextension.com)
- Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p. (sigmaaldrich.com)
- To test this hypothesis, we showed that the combined use of luteolin and mTOR inhibitor rapamycin prevented low doses of luteolin from inducing p21 expression, and HER2-overexpressing cancer cells would be sensitized toward luteolin-induced apoptosis. (aacrjournals.org)
- Apoptotic assays revealed that the multi-heavy metal mixture induced HL7702 cell apoptosis in a dose-dependent manner, which was significantly inhibited by 20 µM luteolin. (spandidos-publications.com)
- The present results suggested luteolin exerts its inhibitory effects of on multi-heavy metal mixture induced cell apoptosis through downregulation of the ROS-activated mitochondrial pathway. (spandidos-publications.com)
- With the deepening of the study on luteolin, researchers have found that it have anti-cancer activities including inhibiting the proliferation of tumor cell, inducing the apoptosis of tumor cells as well as sensitizing anti-cancer drugs. (chemicalbook.com)
- In prostate cancer cells, luteolin treatment inhibited prostate cancer cells proliferation and induced apoptosis through downregulation of miR-301 by triggering DEDD2 expression ( 25 ). (spandidos-publications.com)
- Luteolin also inhibited the tumorigenesis and induced the apoptosis of non-small cell lung cancer cells by upregulation of miR-34a-5p by targeting MDM4 ( 26 ). (spandidos-publications.com)
- And LUT decreased miR-208b-3p expression and apoptosis caused by I/R. However, overexpression of miR-208b-3p further aggravated the changes caused by I/R and blocked all the effects of LUT. (sigmaaldrich.com)
- Next we studied the underlying mechanism of luteolin action, and found its inducing apoptosis of HepG2 cell, apoptosis was monitored based on propidium iodide internalization assay using flow cytometer (FACS). (alliedacademies.org)
- Altogether our result clearly showed the details mechanistic pathway by which luteolin is inducing apoptosis in HepG2. (alliedacademies.org)
- MH exhibited profound inhibitory effects on cellular growth by reducing the proliferation ability, inducing apoptosis and arresting the cell cycle in a dose-dependent manner. (rsc.org)
Mechanism of luteolin1
- To assess the effect and explore the fundamental mechanism of luteolin, we infected several cell lines with two subtypes of influenza A virus (IAV), including A/Jiangxi/312/2006 (H3N2) and A/Fort Monmouth/1/1947 (H1N1) and demonstrated that luteolin suppressed the replication of IAV by cytopathic effect reduction method, qRT-PCR, immunofluorescence and Western blot assays. (springermedizin.de)
- Having multiple biological effects such as anti-inflammation, anti-allergy and anticancer, luteolin functions as either an antioxidant or a pro-oxidant biochemically. (longevityunlocked.com)
- Physicochemical properties and antioxidant activities of luteolin-phospholipid complex. (semanticscholar.org)
- The study, published today in Cancer Prevention Research, a journal of the American Association for Cancer Research, involved the use of microscopic amounts of the naturally occurring antioxidant, luteolin, that were encapsulated in a water-soluble polymer. (redorbit.com)
- Similarly to quercetin, luteolin is an polyphenol antioxidant that may have a variety of beneficial health effects ( 4 , 12 ). (healthline.com)
- Luteolin treatment abated selenite induced oxidative stress and cataractogenesis by maintaining antioxidant status, reducing ROS generation and lipid peroxidation in the lens. (nih.gov)
- These finding demonstrated the anticataractogenic effect of luteolin by virtue of its antioxidant property, which has been reported in this paper for the first time. (nih.gov)
- Salvia plants are traditionally noted for their antioxidant effects and ability to enhance 'head and brain' function, improve memory, quicken the senses, and delay age-associated cognitive decline [ 1 ]. (springer.com)
- Luteolin is a flavinoid with strong antioxidant properties found in the leaves of certian plants. (patientslikeme.com)
- Antioxidant effect of doxycycline decreases MMP activity and blood pressure in SHR. (biomedsearch.com)
- In this study, we hypothesized that doxycycline (a MMP inhibitor) could exert antioxidant effects, reverse establish vascular remodeling, and lower blood pressure in spontaneously hypertensive rats (SHR). (biomedsearch.com)
- Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol, with particular attention on their antioxidant activity. (biomedcentral.com)
- Quercetin is a bioflavonoid found in many plants and grains, known for its positive effects on the immune system and for its antioxidant properties. (versus.com)
- In addition, 20 µM luteolin had a significant inhibitory effect on multi-heavy metal mixture-induced cleavage of caspase-9, caspase-3 and poly(adenosine diphosphate-ribose) polymerase-1 protein. (spandidos-publications.com)
- This inhibitory effect can also explain why many doctors suggest using luteolin to alleviate symptoms of multiple sclerosis. (naturalpedia.com)
- Inhibitory effect of the Pseudobrickellia brasiliensis (Spreng) R.M. King & H. Rob. (thefreelibrary.com)
- The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. (rsc.org)
- It was found that luteolin reversibly inhibited XO in a competitive manner with inhibition constant (Ki) value of (2.38±0.05)×10(-6) mol l(-1). (nih.gov)
- The flavone luteolin has numerous useful actions that include: anti-oxidant, anti-inflammatory, microglia inhibition, neuroprotection, and memory increase. (frontiersin.org)
- Examination of the Akt/mammalian target of rapamycin (mTOR) signaling revealed that this signaling was only transiently inhibited by low doses of luteolin, which suggested that the inability to cause sustained Akt/mTOR inhibition may contribute to p21 induction and provide a survival advantage to HER2-overexpressing cancer cells. (aacrjournals.org)
- In nude mice with xenografted SKOV3.ip1-induced tumors, luteolin significantly inhibited HER2 expression and tumor growth in a dose-dependent manner, and rapamycin further enhanced the effect of luteolin with a concomitant p21 inhibition. (aacrjournals.org)
- miR‑384 inhibition and PTN overexpression partially reversed the inhibition of HT‑29 cells migration and invasion induced by luteolin. (spandidos-publications.com)
- Among the isolated compounds, only luteolin showed in vivo activity: inhibition of serum tumor necrosis factor-α production, inhibition of arachidonic acid-induced ear edema, inhibition of 12- O -tetradecanoylphorbol-13-acetate-induced ear edema and inhibition of oxazolone-induced allergic edema. (go.jp)
- Replacement of 14 C-acetate by 14 C-mevalonate largely omitted the inhibiting effect of artichoke extracts indicating an inhibition at the level of hydroxymethylglutaryl-CoA-reductase. (aspetjournals.org)
- However, no direct inhibition of this enzyme could be detected and no other enzymic steps later in the biosynthetic pathway for cholesterol seemed to be affected. (aspetjournals.org)
- Screening of several known constituents of artichoke extracts revealed that cynaroside and particularly its aglycone luteolin were mainly responsible for inhibition, whereas chlorogenic acid was much less effective and caffeic acid, cynarin and other dicaffeoylquinic acids were without significant influence. (aspetjournals.org)
- Effects of the flavone luteolin, isolated. (ju.edu.jo)
- Luteolin (3′,4′,5,7 tetrahydroxyflavone) is an important flavone present in broccoli, pepper, thyme and celery and naturally found in a glycosylated form. (biomedcentral.com)
- The plant-derived luteolin analogue cynaroside has a glucoside group in position 7 of the flavone A-ring and as opposed to luteolin is unable to stabilize TTR tetramers and thus prevents a cytotoxic effect. (sigmaaldrich.com)
- Observations propose that luteolin could be an anticancer agent for various cancers. (longevityunlocked.com)
- Two chemicals, apigenin and luteolin which are anticancer. (abovetopsecret.com)
- Luteolin (3,4,5,7‑tetrahydroxyflavone) is a natural flavonoid that has been found to exhibit anticancer properties in certain types of cancers. (spandidos-publications.com)
- The present study demonstrated that luteolin exerts anticancer effects against CRC cells by modulating PTN via miR‑384 expression suggested that PTN may serve as a promising candidate for therapeutic applications in CRC treatment. (spandidos-publications.com)
Peanut Shell Extract Luteolin1
- Product Name: peanut shell extract luteolin 98% Latin Name: Arachis hypogaea L. (trader-china.com)
- Luteolin is one of the major components of celery and green peppers, its inhibitory activity on XO and their interaction mechanism were evaluated by multispectroscopic methods, coupled with molecular simulation. (nih.gov)
- Green leaves such as parsley and celery top the list of luteolin-rich foods. (selfhacked.com)
- Luteolin is found in carrots, rosemary, celery and other foods. (lifeextension.com)
- Luteolin is the pigment that gives foods such as celery and parsley their lovely, green color. (naturalpedia.com)
- A 2014 study investigated the effects of celery leaf extract on the cholesterol levels of rats fed a high-fat diet. (medicalnewstoday.com)
- Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. (semanticscholar.org)
- Snopes says it's bunk and that they 'were not able to locate any published research indicating dandelion root affirmatively demonstrated an anti-cancer effect in humans. (abovetopsecret.com)
- This led us to postulate that a long-term daily exposure to low doses of B through diet might be safe and sufficient to produce cancer chemopreventive effect in humans. (degruyter.com)
- These effects have not been studied in humans yet. (pbhfoundation.org)
- However, scientists still need to do further studies to confirm whether luteolin has similar anti-allergy effects in humans. (medicalnewstoday.com)
- flavonoid, apigenin, and luteolin are found in parsley at a greater percentage. (differencebetween.net)
- Despite both coriander and parsley being sources of vitamins and various nutrients, they have some effects on the health of individuals, which is exhibited in different terms. (differencebetween.net)
- However, studies indicate that excessive consumption of parsley is likely to cause uterotonic effects, which causes it to be barred or avoided by pregnant women. (differencebetween.net)
Show that luteolin2
Rich in luteolin2
- Plants sources rich in luteolin have appeared in Chinese traditional medicine for treating many diseases such as hypertension, inflammatory disorders, and cancer. (longevityunlocked.com)
- Plants rich in luteolin content are often used as a traditional Chinese medicine for treatment of disease. (chemicalbook.com)
Apigenin and luteolin2
Properties of luteolin2
- Finally, given these potent anti-inflammatory properties of luteolin, as well as the inverse relationship between flavonoid intake and cognitive decline in older persons and aged animals reported by others, we explored whether dietary supplementation of luteolin can ameliorate age-related deficits in spatial working memory and reduce inflammatory molecules in aged brain. (illinois.edu)
- A luteolin and phospholipid complex was prepared to improve the lipophilic properties of luteolin. (semanticscholar.org)
Quercetin and Luteolin1
- Quercetin and Luteolin are safe. (longevityunlocked.com)
- Effects of Luteolin on Proliferation and Programmed Cell Death of Human Multiple Myeloma Cell RPMI-8226]. (greenmedinfo.com)
- To investigate the effect of Luteolin on proliferation and cell death of human multiple myeloma cell line RPMI-8226 and its mechanisms. (greenmedinfo.com)
- The results showed luteolin inhibited MCF-7 cells proliferation in a dose - and time -dependent manner, and the expression of Bcl-2 protein was decreased. (bvsalud.org)
- On the other hand, combined treatment with luteolin (Lut, 0.5 μ and quercetin (Que, 0.5 μ.M) profoundly decreased MDA-MB-231 proliferation by down-regulating α9-nAChR expression. (elsevier.com)
- First, the effects of luteolin on CRC cells proliferation, migration and invasion were examined by CCK‑8, wound healing and Transwell assays, respectively. (spandidos-publications.com)
- It was demonstrated that luteolin had no effects on CRC cells proliferation while inhibited cells migration and invasion both in vitro and in vivo. (spandidos-publications.com)
- Herbal traditions around the globe use luteolin-rich plants to strengthen the immune system , relieve inflammation, and even combat cancer [ 1 , 2 ]. (selfhacked.com)
- Luteolin is considered by some to be a supper nutrient as it helps reduce inflammation, and promotes nerve and muscle function. (longevityunlocked.com)
- 3.Luteolin applied in pharmaceutical field, Luteolin can play the role of inflammation. (alibaba.com)
- Rodney Johnson and his associates at the University of Illinois report in the October, 2010 issue of the Journal of Nutrition that the flavonoid luteolin helped reduce inflammation in the brains of aged mice, which restored memory to levels observed in younger animals. (lifeextension.com)
- When we provided the old mice luteolin in the diet it reduced inflammation in the brain and at the same time restored working memory to what was seen in young cohorts," Dr Johnson stated. (lifeextension.com)
- Salvia plants and their constituents can influence several biological mechanisms associated with cognition including their effects on amyloid-β, cholinergic activity, neurotrophins, oxidative stress, inflammation and anxiolytic/antidepressant behaviours. (springer.com)
- Luteolin is often used as an additive treatment for brain damage caused by inflammation. (naturalpedia.com)
- Luteolin treatment resulted in reduced inflammation and axonal damage in the CNS by preventing monocyte migration across the brain endothelium. (rupress.org)
- Effects of NZ-107 on Airway Inflammation and Cell Activation in Guinea-Pigs. (nii.ac.jp)
- A 2017 study investigated whether luteolin could reduce inflammation and lower allergic responses in mice with these conditions. (medicalnewstoday.com)
- Results showed that giving the mice luteolin 30 minutes before exposing them to an allergen significantly reduced the levels of inflammation within their lungs and nasal passages. (medicalnewstoday.com)
- A 2013 study investigated whether luteolin could reduce inflammation and protect against neurodegeneration in rodents with diabetic encephalopathy (DE). (medicalnewstoday.com)
- This supplement does a really good job of helping you overcome all those toxic- and inflammation-related effects. (blogarama.com)
- Luteolin also is thought to slow age-related memory loss by halting the release of molecules that cause brain inflammation. (healthcentral.com)
- Researchers from the University of Illinois studied the effect of a luteolin diet on older mice, which have increased brain inflammation compared to young mice, and found that the mice on the luteolin diet performed better with memory tasks and had much lower inflammation levels. (healthcentral.com)
- Manuka honey (MH) represents a good source of phenolic compounds such as luteolin, kaempferol, quercetin, gallic acid and syringic acid. (rsc.org)
- Our previous study indicated that dietary luteolin (LU) could prevent the establishment of insulin resistance in mice fed a high-fat diet (HFD). (springermedizin.de)
- Effect of diosmin administration in patients with chronic venous disorders on selected factors affecting angiogenesis. (greenmedinfo.com)
- The purpose of the present study was to investigate the effect of luteolin on the angiogenesis and invasion of breast cancer cells . (bvsalud.org)
- The chick chorioallantoic membrane model was used to assess the angiogenesis effect . (bvsalud.org)
- Luteolin had a strong anti-angiogenesis of chick chorioallantoic membrane . (bvsalud.org)
- Phytochylomicron as a dual nanocarrier for liver cancer targeting of luteolin: in vitro appraisal and pharmacodynamics. (semanticscholar.org)
- Luteolin inhibited the invasion,migration and adhesion ability of HepG2 cells in vitro in a dose -dependent manner. (bvsalud.org)
- Free radical mediated oxidative stress plays a crucial role in the pathogenesis of cataract and the present study was to determine the efficacy of luteolin in preventing selenite induced oxidative stress and cataractogenesis in vitro. (nih.gov)
- Using the inhibitory activity of TNF-α production in vitro as the index for isolation, we searched the active constituents from PLE and isolated luteolin, rosmarinic acid and caffeic acid as active components. (go.jp)
- The present review will describe the biological effects of oleuropein and hydroxytyrosol, with particular attention on the molecular mechanism underlying the protective action on cardiovascular and metabolic alterations, as demonstrated by in vitro and in vivo experimental studies performed with the isolated compounds. (biomedcentral.com)
- TNBC and some of the bioactive natural compounds known to be capable of having an effect. (canceractive.com)
- But over the last decade, more and more research has been recorded showing how bioactive natural compounds have an effect in preventing and correcting breast cancer, and even with TNBC. (canceractive.com)
- Now, increasingly, many bioactive compounds in nature are being shown to have positive effects. (canceractive.com)
- Methylated luteolin analogs with increased activity and better bioavailability could be developed into effective treatments for neuropsychiatric disorders and brain "fog. (frontiersin.org)
- In over-the-counter supplement form, the first compound, luteolin, is commonly recommended for the treatment of pediatric autism spectrum disorders. (bio-medicine.org)
- But then in an endometrial cancer cell model, luteolin had two deleterious effects. (bio-medicine.org)
- First, it acted like estrogen to directly stimulate cancer cell growth and second, by again blocking progesterone's action, luteolin disabled the brake that progesterone puts on estrogen-dependent endometrial cancer growth. (bio-medicine.org)
- Luteolin is a common flavonoid. (longevityunlocked.com)
- The effect of Luteolin on the growth of human multiple myeloma cell line RPMI-8226 was detected by CCK-8, and then the minimal effective concentration was determined and was used to treat RPMI-8226 cells. (greenmedinfo.com)
- The effects of luteolin and chloroquine on expression of cleaved-caspase 3 and LC3 in RPMI8826 cells was detected by Western blot. (greenmedinfo.com)
- The toxicity of luteolin was evaluated through modified 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay in human retinal microvascular endothelial cells (HRMECs) as well as TUNEL staining in the retina of C57BL/6J mice. (arvojournals.org)
- Many studies have shown the antiproliferative actions of luteolin on cancer cells. (longevityunlocked.com)
- However, the effects of luteolin on incursion of cancer cells remain unclear. (longevityunlocked.com)
- 4.Luteolin can reduce the level of hepatic fibrosis and protect liver cells from damage. (alibaba.com)
- Luteolin also shows potent anti-inflammatory activities by inhibiting nuclear factor kappa B (NFkB) signaling in immune cells. (semanticscholar.org)
- Immunomodulatory Effects of Psyllium Extract on Helicobacter pylori Interaction With Gastric Epithelial Cells. (semanticscholar.org)
- Compound A, a plant origin ligand of glucocorticoid receptors, increases regulatory T cells and M2 macrophages to attenuate experimental autoimmune neuritis with reduced side effects. (semanticscholar.org)
- Luteolin-loaded phytosomes sensitize human breast carcinoma MDA-MB 231 cells to doxorubicin by suppressing Nrf2 mediated signalling. (semanticscholar.org)
- To investigate the effects of luteolin on invasion,migration and adhesion of human hepatocelluar carcinoma HepG2 cells . (bvsalud.org)
- HepG2 cells were cultured and treated with luteolin at 10 ,20 and 40 μmol/L respectively.The invasion capability was examined by cell invasion assay.The migration ability was examined by wound healing assay.The adhesion capability was measured by adhesion assay.The protein levels of E-cadherin , N-cadherin , vimentin and Snai1 were determined by Western blot analysis . (bvsalud.org)
- Both α5- and α9-nAChR appear to be important molecular targets for Lut- and Que-induced antitumor effects in human breast cancer cells. (elsevier.com)
- In the present study, the inhibitory effects of luteolin on the combined toxicity of multi-heavy metals (including zinc, manganese, lead, copper, cadmium, mercury, chromium and nickel) were investigated in HL7702 hepatocyte cells. (spandidos-publications.com)
- Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells. (nih.gov)
- When injected into mice the nano-luteolin inhibited growth of lung cancer and head and neck cancer cells. (redorbit.com)
- The current research, funded by the National Institutes of Health, examined luteolin's effect in immune cells in the brain known as microglial cells, which produce inflammatory signaling molecules in response to infection. (lifeextension.com)
- It's doing it by affecting the microglial cells. (lifeextension.com)
- The study is the first to indicate that luteolin increases cognitive function by acting on the microglial cells. (lifeextension.com)
- Different concentrations of B and D (0.29-290 μg/ml) and in various combinations (B:D ratio = 1:0, 1:1, 5:1, 1:5 and 0:1) were tested for cytotoxic effects against the three cancer cells. (degruyter.com)
- Luteolin was found to upregulate miR‑384 and downregulate PTN expressions both in CRC cells and tissues. (spandidos-publications.com)
- Zhou et al found that luteolin upregulated miR-34 expression in gastric cancer cells and upregulation of miR-34 enhanced the susceptibility of cells to luteolin ( 6 ). (spandidos-publications.com)
- Thus, we hypothesized that miRNAs play significant roles during luteolin treatment in CRC cells and this has not yet been investigated. (spandidos-publications.com)
- Mice studies have shown that luteolin was particularly efficient in reducing tumor growth in ovarian cancer cells. (naturalpedia.com)
- Luteolin is a flavonoid and considered to be important for anti-cancer activity against many cancer cells. (alliedacademies.org)
- In this study we checked luteolin activity against number of cell line and according to our screen mouse liver cancer cells (HepG2) is found to be most susceptible to its action. (alliedacademies.org)
- Further investigation revealed that luteolin is causing extensive DNA degradation in HepG2 cells. (alliedacademies.org)
- In this study, we investigated the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on UCP3 gene expression in C 2 C 12 muscle cells. (mdpi.com)
- Lee M-S, Kim I-H, Kim Y. Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Uncoupling Protein 3 Gene Expression in C 2 C 12 Muscle Cells. (mdpi.com)
- In the lab, luteolin was administered to human breast cancer cells and researchers used luteolin to observe the stem cell-like characteristics in the cancer cells. (doctorshealthpress.com)
- The luteolin displayed its anti-tumor effects by shrinking the breast cancer cells. (doctorshealthpress.com)
- According to a 2016 review , luteolin can halt the growth of some types of cancer cells in rodents. (medicalnewstoday.com)
- Luteolin may also prevent cancer cells from invading other areas of the body, or 'metastasizing. (medicalnewstoday.com)
- Chemoprotection of haematopoietic stem cells (HSCs) by gene therapeutic transfer of drug-resistance genes represents the encouraging approach to prevent myelosuppression, which is one of the most severe side effects in tumor therapy. (biomedsearch.com)
- The aim of this work was to evaluate the chemopreventive effects of MH on human colon cancer HCT-116 and LoVo cells. (rsc.org)
- The effects of different concentrations of Luteolin extract on prednisone/prednisolone metabolism indicated the enzyme activity of 11 β -HSD, so the production rate (pmol/min per mg protein) of metabolites was used to indicate enzyme activity. (hindawi.com)
- Our results showed that oral administration of Luteolin significantly increased the gene and protein expressions of hepatic 11 β -HSD I and renal 11 β -HSD II, which may improve the efficacy and reduce the adverse drug effect of glucocorticoid in clinical application. (hindawi.com)
- And while there's some room for cause-and-effect arguing in some of these, in others it seems clear that the primary event is protein aggregation . (sciencemag.org)
- In addition, we found that luteolin suppressed coat protein I complex expression, which was related to influenza virus entry and endocytic pathway. (springermedizin.de)
- Lutimax is a 50:50 mix of luteolin and rutin. (patientslikeme.com)
- Supplements containing healthy phytochemicals and botanical extracts have been proven to alleviate symptoms without negative side effects, and balance the immune system so it doesn't over-react to allergens. (smart-publications.com)
- However, botanical extracts have been shown to provide relief to allergy sufferers, safely and naturally, without side effects. (smart-publications.com)
- When properly harvested and processed, the following botanical extracts provide a synergistic effect to help control the common symptoms and causes of allergies by inhibiting histamine release and, more importantly, correcting immune system dysfunction. (smart-publications.com)
- Additionally, these botanical extracts do not have unpleasant side-effects like drowsiness or dry mouth associated with pharmaceuticals. (smart-publications.com)
- Further research is required to examine the longer-term cognitive-enhancing effects of Salvia species on cognition, memory and the treatment of neurodegenerative diseases such as Alzheimer's disease. (springer.com)
- The findings of the current study suggest that the luteolin might have a beneficial effect against DCM via improvement the Akt/GSK-3β signalling pathway. (alliedacademies.org)
- Our previous study revealed that Eclipta prostrata (EP) affected the activity and expression of 11 β -HSD enzymes which might improve the efficacy and reduce the adverse drug effects of glucocorticoid in patients undergoing combinational therapy. (hindawi.com)
- Efficacy of ultramicronized palmitoylethanolamide in burning mouth syndrome-affected patients. (greenmedinfo.com)
- Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant. (mdpi.com)
- This may subsequently influence the pharmacokinetic and pharmacodynamic properties of drugs, leading to their changed efficacy and undesired effects [ 5 , 6 ]. (mdpi.com)
- There is a wealth of evidence that prove the efficacy of luteolin in cancer growth interference . (naturalpedia.com)
- This allows manufacturers to market supplements without fully testing nutraceutical products for efficacy or potential side effects. (bio-medicine.org)
- Deacetylation performed by HDAC molecules has the opposite effect. (wikipedia.org)
- Anti-angiogenic activity of luteolin was evaluated by VEGF-induced migration and tube formation assay. (arvojournals.org)
- An MTT assay demonstrated that 20 µM luteolin significantly alleviated the multi-heavy metal mixture-induced cell death and morphological changes. (spandidos-publications.com)
- A JC-1 staining assay indicated that 20 µM luteolin inhibited the mitochondrial membrane potential-reducing effect of the multi-heavy metal mixture. (spandidos-publications.com)
- Next we measured ROS generation ability and lipid peroxidation effect induced by luteolin and measured using TBARS assay. (alliedacademies.org)
- Cytotoxic effects detected by lactate dehydrogenase leakage and the 3-[4,5-dimethylthiazol-2-yl]-2,5-dephenyl tetrazolium bromide-assay were restricted to higher concentrations. (aspetjournals.org)
- The chamomile oil can be processed into pills, but the flower head can also be used as a whole to make use of the beneficial effect. (wikipedia.org)
- Therefore, in the current study, we have used the rat model of DCM induced via a low dose of STZ and intake the high energy to the rats, to scrutinize the beneficial effect and possible mechanism of action. (alliedacademies.org)
- New research has found IL-6 to be an anti-inflammatory cytokine with multiple beneficial effects when released by contracting muscle as a myokine. (wikipedia.org)
- Anti-IL-6 therapies should therefore take into consideration the (beneficial) anti-inflammatory effects of myokines generally, including the now-established multiple benefits of muscle-derived Interleukin 6. (wikipedia.org)
- In the present work, Nordeen showed that luteolin blocked this increase a beneficial effect. (bio-medicine.org)
- Scientific studies suggest that this cactus can have beneficial effects on the liver diseases . (botanical-online.com)
- Protective effects of luteolin against apoptotic liver damage induced by D-galactosamine/lipopolysaccharide in mice. (sparrho.com)
- In this study, the protective effects of luteolin (1, a major component of Cirsium japonicum) were examined against d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure. (sparrho.com)
- Protective effects of Mg-CUD against D-galactosamine-induced hepatotoxicity in rats. (sparrho.com)
- Luteolin (LUT), a kind of flavonoid which is extracted from a variety of diets, has been reported to convey protective effects of various diseases. (sigmaaldrich.com)
- Recent researches have suggested that LUT can carry out cardioprotective effects during ischemia/reperfusion (I/R). However, there have no reports on whether LUT can exert protective effects against myocardial I/R injury through the actions of specific microRNAs (miRs). (sigmaaldrich.com)
- A new formulation called "BrainGain" promises to amplify luteolin's protective effects. (drhoffman.com)
- While pretreatment of neurons with luteolin showed no benefit, exposure of microglia to this compound prevented neuron death. (lifeextension.com)
- This demonstrated that luteolin isn't protecting the neurons directly," Dr Johnson stated. (lifeextension.com)
- The neurons survived because the luteolin inhibited the production of neurotoxic inflammatory mediators. (lifeextension.com)
- Luteolin reduces IL-6 production in some neurons. (wikipedia.org)
- These diseases involve various characteristic pathological and molecular features affecting neurons in various regions of the brain. (intechopen.com)
- This study was performed to investigate the anti-angiogenic effect of luteolin against reactive oxygen species (ROS)-induced retinal neovascularization. (arvojournals.org)
- In this study, we showed that luteolin, a naturally occurring flavonoid, is a potent stimulator of HER2 degradation. (aacrjournals.org)
- Our results suggest that nanoparticle delivery of naturally occurring dietary agents like luteolin has many advantages," says senior study author Dong Moon Shin, MD, professor of hematology and medical oncology at Emory University School of Medicine and associate director of academic development at Winship Cancer Institute. (redorbit.com)
- Luteolin was purchased from the Sigma Aldrich, USA and all other chemical used in the experimental study were purchased from Sigma Aldrich, USA. (alliedacademies.org)
- One Japanese study showed that luteolin can reduce the number and severity of the Japanese encephalitis virus. (naturalpedia.com)
- The objective of the project will be study the effect of low power microwaves on the malaria parasite Plasmodium falciparum. (malariaworld.org)
- In a new study published in the journal Springer Plus , University of Missouri researchers found that luteolin can decrease breast cancer risk in women taking hormone replacement therapy. (doctorshealthpress.com)
- In the study, rats that the investigators continuously treated with luteolin had reduced brain cell damage and improved learning and memory. (medicalnewstoday.com)
- A Randomized, Double Blind, Placebo Controlled, Parallel-Group Study to evaluate the effect of Terminalia chebula, Terminalia bellerica and Febuxostat in patients with hyperuricemia. (bodybuilding.com)
- The purpose of this study is to examine the physiological and performance effects of T+ on power athletes. (clinicaltrials.gov)
- Luteolin, a plant derived flavonoid, exerts a variety of pharmacological activities and anti-oxidant properties associated with its capacity to scavenge oxygen and nitrogen species. (semanticscholar.org)
- The molecular docking results revealed luteolin actually interacted with the primary amino acid residues located within the active site pocket of XO. (nih.gov)
- Basic research results indicate luteolin as an anti-inflammatory agent with other potential effects on septic shock. (longevityunlocked.com)
- The results showed that luteolin and phospholipid in the complex were joined by non-covalent-bonds and did not form a new compound. (semanticscholar.org)
- The results show that the A-ring of luteolin, in contrast to what was previously suggested, is buried within the TBS, consequently explaining the lack of activity from cynaroside. (sigmaaldrich.com)
- Results of the investigation showed a reduction in fasting blood glucose level, Total Cholesterol (TC) and Triglyceride (TG) in luteolin-treated DCM rats. (alliedacademies.org)
- Finally Quantitative real time PCR analysis results showed that luteolin significantly up-regulated the expression of both intrinsic and extrinsic caspases as well as executioner caspases. (alliedacademies.org)
- Interestingly, although the fiber content is similar, the results showed that only the cactus had hypoglycemic effect. (botanical-online.com)
- Suppressive effects of hot water extract of safflower leaves (Ex) and its major component luteolin-7-O-glucoside (LuGlc) on oxidative stress were determined in rats in which oxidative stress had been induced by paraquat (PQ). (nii.ac.jp)
- Luteolin is a natural anti-oxidant with not as much pro-oxidant (inducing oxidative stress ) potential than the most studied flavonoid quercetin, but apparently with a better safety profile. (longevityunlocked.com)
- Prevention of selenite induced oxidative stress and cataractogenesis by luteolin isolated from Vitex negundo. (nih.gov)
- Concurrently, luteolin possesses potent estrogen agonist activity while quercetin is considerably less effective. (springer.com)
- There is some evidence that alfalfa may act like estrogen, and this might affect the pregnancy. (webmd.com)
- Alfalfa might have the same effects as the female hormone estrogen. (webmd.com)
- The active ingredients claimed to lower plasma estrogen concentrations are red clover, luteolin, resveratrol and nettle root. (clinicaltrials.gov)
- As of yet, however, there is no direct evidence of antitumor effects by agents that block the effect of tobacco compound nicotine (Nie) on relevant nicotinic receptors (nAChR) involved in breast tumorigenesis. (elsevier.com)
- Recently, the antitumor effects of luteolin have been extensively investigated in breast and gastric cancer ( 6 ), melanoma ( 7 ), esophageal carcinoma ( 8 ), glioblastoma ( 9 ), hepatocellular carcinoma ( 10 ), placental choriocarcinoma ( 11 ) and lung adenocarcinoma ( 12 ). (spandidos-publications.com)
- Does the Japanese Honeysuckle have any pharmacological effects? (gmu.edu)
- There are numerous pharmacological effects of Japanese Honeysuckle. (gmu.edu)
- 4 Preclinical studies have shown that the pharmacological effects of luteolin might include anti-oxidant, anti-inflammatory, antibacterial and anti-cancer. (chemicalbook.com)
- Luteolin influenced migration by modulating the activity of Rho GTPases, signal transducers involved in transendothelial migration. (rupress.org)
Morbidity and morta1
- The cardiovascular disease, particularly, the heart failure has been identified as the main cause of morbidity and mortality of patient affected by diabetes. (alliedacademies.org)
- In particular, the effects of plants belonging to the genus Salvia and their constituents on cognitive skills including memory, attention and learning are detailed. (springer.com)
- Luteolin has been identified from various Chinese plants such as Lonicera japonica, Elsholtzia rugulosa, Brassica oleracea and Chrysanthemum morifolium [ 8 ]. (alliedacademies.org)