A group of phenyl benzopyrans named for having structures like FLAVONES.
5,7,4'-trihydroxy-flavone, one of the FLAVONES.
A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.
A plant genus of the family CAPRIFOLIACEAE. Members contain iridoid glucosides.
A plant genus of the family LAMIACEAE that is an ingredient of Banxia Houpu (DRUGS, CHINESE HERBAL).
A plant genus of the family ASTERACEAE. The common names of daisy or marguerite are easily confused with other plants. Some species in this genus have been reclassified to TANACETUM.
Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.
A group of FLAVONOLS based on kaempferol. They are derived from naringenin and can be hydroxylated to QUERCETIN or reduced to leucopelargonidin.
The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).
Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.
A group of 3-hydroxy-4-keto-FLAVONOIDS.
A group of 4-keto-FLAVONOIDS.
A plant genus of the family LAMIACEAE. The common names of beebalm or lemonbalm are also used for MONARDA.
Application of pharmaceutically active agents on the tissues of the EYE.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A group of FLAVONOIDS characterized with a 4-ketone.
A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
The sodium salt of 4-hydroxybutyric acid. It is used for both induction and maintenance of ANESTHESIA.
A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.
Energy transmitted from the sun in the form of electromagnetic radiation.
Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents. For reasons of their ingredients, method of preparation, or use, they do not fall into another group of products.
A plant genus of the family ASTERACEAE that has long been used in folk medicine for treating wounds.
A plant genus of the family OLEACEAE. Oleuropein, a phenolic secoiridoid glycoside, is found in the leaves.
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
Derived from TELENCEPHALON, cerebrum is composed of a right and a left hemisphere. Each contains an outer cerebral cortex and a subcortical basal ganglia. The cerebrum includes all parts within the skull except the MEDULLA OBLONGATA, the PONS, and the CEREBELLUM. Cerebral functions include sensorimotor, emotional, and intellectual activities.
A plant genus of subsucculent annual or perennial plants in the family BALSAMINACEAE, order Geraniales.
A cell line derived from cultured tumor cells.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
The above-ground plant without the roots.
5,7,3',4'-tetrahydroxy-flavone, one of the FLAVONES.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Substances that reduce or suppress INFLAMMATION.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
Cyclohexane ring substituted by one or more ketones in any position.
A family of proteins involved in the transport of monocarboxylic acids such as LACTIC ACID and PYRUVIC ACID across cellular membranes.
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.
A species of gram-negative, aerobic bacteria that causes formation of root nodules on some, but not all, types of sweet clover, MEDICAGO SATIVA, and fenugreek.
A highly vascularized extra-embryonic membrane, formed by the fusion of the CHORION and the ALLANTOIS. It is mostly found in BIRDS and REPTILES. It serves as a model for studying tumor or cell biology, such as angiogenesis and TISSUE TRANSPLANTATION.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other BIOGENIC AMINES and NEUROPEPTIDES.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.
Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.
Dimers (homo and hetero) of FLAVONOIDS.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
A family of diphenylenemethane derivatives.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Use of plants or herbs to treat diseases or to alleviate pain.
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
The reproductive organs of plants.
DNA of kinetoplasts which are specialized MITOCHONDRIA of trypanosomes and related parasitic protozoa within the order KINETOPLASTIDA. Kinetoplast DNA consists of a complex network of numerous catenated rings of two classes; the first being a large number of small DNA duplex rings, called minicircles, approximately 2000 base pairs in length, and the second being several dozen much larger rings, called maxicircles, approximately 37 kb in length.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.
A viral oncoprotein originally isolated from a murine T CELL LYMPHOMA infected with the acutely transforming retrovirus AKT8. v-akt protein is the viral homologue of PROTO-ONCOGENE PROTEINS C-AKT.
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A large class of organic compounds having more than one PHENOL group.
The cellular signaling system that halts the progression of cells through MITOSIS or MEIOSIS if a defect that will affect CHROMOSOME SEGREGATION is detected.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.
A genus of gram-negative, aerobic, rod-shaped bacteria that activate PLANT ROOT NODULATION in leguminous plants. Members of this genus are nitrogen-fixing and common soil inhabitants.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM, and divide them equally between two daughter cells. If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or "arrested") until the processes are completed and growth conditions are suitable.
Uptake of substances through the lining of the INTESTINES.
A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Transcription factors that form transcription initiation complexes on DNA, bind to specific DNA-DIRECTED RNA POLYMERASES and are required to initiate transcription. Although their binding may be localized to distinct sequence and structural motifs within the DNA they are considered non-specific with regard to the specific gene being transcribed.
A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.
The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
The finer blood vessels of the vasculature that are generally less than 100 microns in internal diameter.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). The sandfly genera Phlebotomus and Lutzomyia are the vectors.
Tumors or cancer of the PROSTATE.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
The relationship between two different species of organisms that are interdependent; each gains benefits from the other or a relationship between different species where both of the organisms in question benefit from the presence of the other.
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
A continuous cell line that is a substrain of SWISS 3T3 CELLS developed though clonal isolation. The mouse fibroblast cells undergo an adipose-like conversion as they move to a confluent and contact-inhibited state.
Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.
The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.
Compounds that inhibit the activity of DNA TOPOISOMERASE I.
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Examinations used to diagnose and treat heart conditions.
Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)
Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
Endothelial cells that line venous vessels of the UMBILICAL CORD.
Culture media containing biologically active components obtained from previously cultured cells or tissues that have released into the media substances affecting certain cell functions (e.g., growth, lysis).
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
The action of a drug in promoting or enhancing the effectiveness of another drug.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.
A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.
Regular course of eating and drinking adopted by a person or animal.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
Established cell cultures that have the potential to propagate indefinitely.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Tumors or cancer of the SKIN.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.
Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
The giving of drugs, chemicals, or other substances by mouth.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Tumors or cancer of the COLON.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Glycoproteins found on the membrane or surface of cells.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The rate dynamics in chemical or physical systems.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Tumors or cancer of the LUNG.
It is also used as a mild laxative and has an anti-inflammatory and bactericidal effect . Research with animals suggests ... and luteolin; and coumarin. German chamomile is used in herbal medicine for a sore stomach, skin care, irritable bowel syndrome ... but the flower head can also be used as a whole to make use of the beneficial effect. It can be taken as a herbal tea, two ... antispasmodic, anxiolytic, anti-inflammatory and some antimutagenic and cholesterol-lowering effects for chamomile. As well ...
Qiusheng Z, Yuntao Z, Rongliang Z, Dean G, Changling L (July 2005). "Effects of verbascoside and luteolin on oxidative damage ... Acetylation has the effect of changing the overall charge of the histone tail from positive to neutral. Nucleosome formation is ... Glucose availability affects the intracellular pool of acetyl-CoA, a central metabolic intermediate that is also the acetyl ... It has been shown that, even past one replication, expression of genes may still be affected many cell generations later. A ...
... incarnata may increase main effects or side effects of medications listed above. For oral consumption, pregnant or ... Other flavonoids present in P. incarnata include chrysin, apigenin, luteolin, quercetin, kaempferol, and isovitexin. The main ... The effects of oral ingestion of the plant compounds on reproduction or on unborn child have not been tested. P. incarnata ... Ingale, Suvarna P; Kasture, Sanjay B (2017). "Protective Effect of Standardized Extract of Passiflora incarnata Flower in ...
"Luteolin shows antidepressant-like effect by inhibiting and downregulating plasma membrane monoamine transporter (PMAT, Slc29a4 ... These compounds include: Luteolin Cimetidine Decynium-22 Dipyridamole Quinidine Quinine Tryptamine Verapamil Acetylcholine ( ...
... luteolin-8-hexityl monoxyloside), Homoadonivernith, Orientin, Homoorientin, Isoorientin, Luteolin, and Vitexin. There are many ... These glycosides also have a sedative effect and is often prescribed to patients whose hearts are beating irregularly or at an ... Esmail, Al-Snafi Ali (2015). "THERAPEUTIC PROPERTIES OF MEDICINAL PLANTS: A REVIEW OF PLANTS WITH CARDIOVASCULAR EFFECTS (PART ... Esmail, Al-Snafi Ali (2015). "THERAPEUTIC PROPERTIES OF MEDICINAL PLANTS: A REVIEW OF PLANTS WITH CARDIOVASCULAR EFFECTS (PART ...
Luteolin reduces IL-6 production in some neurons. Jones SA, Scheller J, Rose-John S (2011). "Therapeutic strategies for the ... 2013). "Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic diseases: systematic ... New research has found IL-6 to be an anti-inflammatory cytokine with multiple beneficial effects when released by contracting ... Jang S, Kelley KW, Johnson RW (2008). "Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and ...
A study was designed to see the effect of Viola tricolor against neuronlastoma N2a cells. In the end, there was no significant ... Heartsease contains flavonoids (such as quercetin, luteolin and rutin), colorless crystalline compounds proven to be useful in ... Shakespeare mentions it in his play The Taming of the Shrew where Luciento claims he found the effect of love-in-idleness - ... V. tricolor extract had anti-inflammatory effect in acute inflammation induced in male Wistar rats. The plant, especially the ...
The flavonoid luteolin inhibits niacin-induced flush. Brit J Pharmacol. 2008, 153 (7): 1382-87. PMC 2437911. PMID 18223672. doi ... Hirano, T; Kawai, M; Arimitsu, J; Ogawa, M; Kuwahara, Y; Hagihara, K; Shima, Y; Narazaki, M; Ogata, A. Preventative effect of a ... Kawai, M; Hirano, T; Arimitsu, J; Higa, S; Kuwahara, Y; Hagihara, K; Shima, Y; Narazaki, M; Ogata, A. Effect of enzymatically ... Bun SS, Giacometti S, Fanciullino R, Ciccolini J, Bun H, Aubert C. Effect of several compounds on biliary excretion of ...
... have effects on CYP (P450) activity which are enzymes that metabolize most drugs in the body. In organic chemistry ... Common flavones include apigenin (4',5,7-trihydroxyflavone), luteolin (3',4',5,7-tetrahydroxyflavone), tangeritin (4',5,6,7,8- ... Flavones have no proven physiological effects in the human body and no antioxidant food value. Following ingestion and ...
... luteolin, linarin, luteolin 3',4'-dimethylether-7-O-beta-D-glucoside, isoferulic acid, and ethyl rosmarinate. Lobelia chinensis ... is considered mildly toxic due to its adverse effects, including vomiting, heartburn, anxiety, vibrating, eclampsia, increased ...
Affected animals will lose weight, or fail to gain weight; young animals are more affected than old animals. In severe cases ... luteolin) Phenolic acids (e.g. chlorogenic acid, caffeic acid, p-coumaric acid, ferulic acid, p-hydroxybenzoic acid, vanillic ... The organ systems affected by ADRs to St John's Wort and fluoxetine have a similar profile, with the majority of cases ... Some affected animals may accidentally drown. Poor performance of suckling lambs (pigmented and non-pigmented) has been noted, ...
"In Vitro and In Vivo α-Glucosidase and α-Amylase Inhibitory Effects of the Water Extract of Leaves of Pepper (Capcicum Annuum L ... Cultivar Dangjo) and the Active Constituent Luteolin 7-O-Glucoside". Journal of Food Biochemistry. 40 (5): 696-703. doi:10.1111 ...
Although it has received considerable media attention purporting its effects on weight loss, there is liver toxicity associated ... Other compounds identified in the fruit include the polyphenols, luteolin, and kaempferol. In late 2012, a United States ... Adverse events associated with use of such supplements ("side effects") - especially, liver toxicity, as well as ... the evidence for Garcinia cambogia supports no clear effect, while gastrointestinal adverse events were two-fold more common ...
Luteolin, supplement extracted from peanuts that also possesses IGF-1 properties. Drotaverine, used to alleviate renal colic ... Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats; An Torremans, Abdellah ... Shamim MT, Ukena D, Padgett WL, Daly JW (June 1989). "Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono ... Yu MC, Chen JH, Lai CY, Han CY, Ko WC (2009). "Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, ...
Polyphenols found in the species and subspecies: Thymus zygis Apigenin Cirsimaritin Luteolin 6-OH-Luteolin Xanthomicrol Vicenin ... Additionally, there was not any cytotoxic effects shown on eukaryotic mammalian cells at concentrations that are effective ...
O-methylation has an effect on the solubility of flavonoids. O-methylated flavonoids formation implies the presence of specific ... O-methyltransferase Luteolin O-methyltransferase Methylquercetagetin 6-O-methyltransferase 3-methylquercetin 7-O- ...
... is a source of flavonoids and antioxidants, especially luteolin, apigenin, folate, vitamin K, vitamin C, and vitamin A ... Normal food quantities are safe for pregnant women, but consuming excessively large amounts may have uterotonic effects. ...
The predominant active constituents are nerol acetate, curcumin, pinene, limonene, kaempherol, quercetin, luteolin, linalool, ... stems and foliage which have confirmed that it has an inhibitory effect on some bacteria and viruses. Due to the intense ...
Barbaro, B; Toietta, G; Maggio, R; Arciello, M; Tarocchi, M; Galli, A; Balsano, C (2014). "Effects of the Olive-Derived ... including luteolin, rutin, caffeic acid, catechin and apigenin. Elenolic acid is a component of olive oil and olive leaf ... However, scientific evidence for health effects of using olive leaf extract has been deemed insufficient by the European Food ... the leaf and its extracts remain under preliminary research with unknown effects on human health. The silvery green leaves are ...
... has shown to have anti-proliferative effects on many types of cancer cells by inhibiting cancer cell lipogenesis. By ... An, Sang Mi; Kim, Hyo Jung; Kim, Jung-Eun; Boo, Yong Chool (2008). "Flavonoids, taxifolin and luteolin attenuate cellular ... There is also a strong correlation (with a correlation coefficient of 0.93) between the antiproliferative effects of taxifolin ... Lee, Saet Byoul; Cha, Kwang Hyun; Selenge, Dangaa; Solongo, Amgalan; Nho, Chu Won (2007). "The Chemopreventive Effect of ...
Despite the presence of coumarin, as chamomile's effect on the coagulation system has not yet been studied, it is unknown if a ... The main constituents of chamomile flowers are polyphenol compounds, including apigenin, quercetin, patuletin, and luteolin. ... There is insufficient scientific evidence that consuming chamomile in foods or beverages has any effect on health. The word " ... there is insufficient clinical evidence about its potential for affecting nursing infants. The chamomile plant is known to be ...
Nausea, vomiting, and related general gastrointestinal side effects are the most commonly implicated side effects of PDE4 ... Yu, M. C.; Chen, J. H.; Lai, C. Y.; Han, C. Y.; Ko, W. C. (2009). "Luteolin, a non-selective competitive inhibitor of ... Other possible side effects include respiratory and urinary tract infections, which have been discovered from the clinical use ... Luteolin, supplement extracted from peanuts that also possesses IGF-1 properties. Mesembrenone, an alkaloid from the herb ...
recently described the up-regulation of Smr15C2 under cold shock stress, while no effects of a temperature downshift were ... and luteolin-MM broth and endosymbiotic bacteria (i.e. mature symbiotic alfalfa nodules), high salt stress, oxidative stress ...
Cytokine effects on behavior. In R. Ader, D.L. Felten and N. Cohen (Eds.) Psychoneuroimmunology. Third Edition. Academic Press ... Luteolin reduces interleukin-6 production in microglia by inhibiting c-Jun N-terminal kinase phosphorylation and activation of ... In early 2000s, Kelley was asked to share his new concept of how TNF affects neurons and other cells for Trends in Neuroscience ... The pituitary gland is required for protection against lethal effects of Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 88: ...
Its effects against the proliferation of viruses is thought to be a consequence of myricetin's ability to inhibit the proper ... Myricetin is structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same functions as ... Although myricetin has not been concluded to have more than a neutral effect on humans, it has been used as a form of ... This insulinomimetic effect is hypothesized to be a consequence of myricetin's either direct or indirect interaction with GLUT4 ...
6.^ An, Sang Mi; Kim, Hyo Jung; Kim, Jung-Eun; Boo, Yong Chool (2008). "Flavonoids, taxifolin and luteolin attenuate cellular ... 2.^ Lee, Saet Byoul; Cha, Kwang Hyun; Selenge, Dangaa; Solongo, Amgalan; Nho, Chu Won (2007). "The Chemopreventive Effect of ... 1.^ Makena, Patrudu S.; Pierce, Samuel C.; Chung, King-Thom; Sinclair, Scott E. (2009). "Comparative mutagenic effects of ...
This effect was produced by applying a thin transparent layer of paint-a glaze-over the black background seen now. However, the ... The dark background of the painting contains bone black, weld (luteolin, reseda luteola), chalk, small amounts of red ochre, ...
The plant is rich in luteolin, a flavonoid which produces a bright yellow dye. The yellow could be mixed with the blue from ... Any ecological, medical or health effects of barbarin and resedine are poorly understood. Ramses Wissa Wassef Art Centre annual ...
The antiviral effects of naringenin are currently under clinical investigation. Reports of antiviral effects on polioviruses, ... Gutiérrez-Venegas, Gloria; Kawasaki-Cárdenas, Perla; Rita Arroyo-Cruz, Santa; Maldonado-Frías, Silvia (2006-07-10). "Luteolin ... PMID 8485024.Ueng YF, Chang YL, Oda Y, Park SS, Liao JF, Lin MF, Chen CF (1999). "In vitro and in vivo effects of naringin on ... Naringenin also produces BDNF-dependent antidepressant-like effects in mice.Yi LT, Liu BB, Li J, Luo L, Liu Q, Geng D, Tang Y, ...
Selye H (1 January 1941). "Anesthetic Effect of Steroid Hormones". Experimental Biology and Medicine. 46 (1): 116-121. doi: ... GABAA PAMs increase the effect of GABA by making the channel open more frequently or for longer periods. However, they have no ... S(-) form of barbiturate have shown more depressant activity while the R(+) isomers have an excitatory effect.[28] ... Preclinical studies have shown that benzodiazepines can be effective in reducing the effect of strokes for up to three days ...
Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R, Ren H, Li ZW, Wong JT, Xue H (2002). "Anxiolytic effect of wogonin, a ... "GABA A receptor subtype selectivity underlying selective anxiolytic effect of baicalin". Neuropharmacology. 55 (7): 1231-7. ...
Since the dose margin between the anticonvulsant and hypnotic effect is small, paraldehyde treatment usually results in sleep. ... though there is no known mechanism for this function beyond the placebo effect). ...
R. Padmavathi u. a.: Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12 ... A sebgyógyítás képességét az apigenin és luteolin jelenlétével magyarázzák.[32] Az állatkísérletek szerint a daganatok ... R. Padmavathi et al.: Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12 ... június 1.). „The effect of bee propolis on recurrent aphthous stomatitis: a pilot study". Clin Oral Investig. 11 (2), 143-7. o ...
Among these, cough is the most common adverse effect. Hyperkalemia can occur, especially if used with other drugs which elevate ... Ajayi AA, Campbell BC, Rubin PC, Reid JL (November 1985). "Effect of naloxone on the actions of captopril". Clinical ...
A phenyl group in substituent R6 showed effect on norepinephrine transporters. Substituent groups in R6 and R7 with allylic ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ... This effect of SNRIs results in increased dopamine neurotransmission, in addition to the increases in serotonin and ... Beesdo K, Hartford J, Russell J, Spann M, Ball S, Wittchen HU (December 2009). "The short- and long-term effect of duloxetine ...
Basáñez MG, Pion SD, Boakes E, Filipe JA, Churcher TS, Boussinesq M (May 2008). "Effect of single-dose ivermectin on Onchocerca ... For dogs, the insecticide spinosad may have the effect of increasing the potency of ivermectin.[49] ... "Effect of a single standard dose (150-200 μg/kg) of ivermectin on microfilaremia: systematic review and meta-analysis". Open ...
... went into her trance-like state as an effect of ethylene rising from ground faults.[47] ... "Effect of ethylene on flower abscission: a survey". Annals of Botany. 89 (6): 689-693. doi:10.1093/aob/mcf124. PMC 4233834 ... synthesis is less effective for reducing post-harvest losses since ethylene from other sources can still have an effect. By ...
I found the effect of love in idleness;. And now in plainness do confess to thee,. That art to me as secret and as dear. As ... luteolin and rutin. Various carotenoids have been isolated from the drug : violaxanthin, antheraxanthin, lutein, zeaxanthin and ... Shakespeare mentions it in his play The Taming of the Shrew where Luciento claims he found the effect of love-in-idleness - ... The study is designed to see the effect of Viola tricolor against neuronlastoma N2a cells. In the end, there was no significant ...
Adverse effect incidence[2][3][4]. Very common (,10% incidence) adverse effects include: ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
Okuma T, Kishimoto A (February 1998). "A history of investigation on the mood stabilizing effect of carbamazepine in Japan". ... this unusual side effect is usually not noticed by most people, and disappears after the person stops taking carbamazepine.[18] ... rare case reports of an auditory side effect have been made, whereby patients perceive sounds about a semitone lower than ...
Effect of a new series of bicyclic compounds with potential thymoleptic properties on the reserpine-resistant uptake mechanism ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
Food effect on the overall bioavailability of armodafinil is considered minimal; however, time to reach peak concentration may ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
In concentrations of 3-5% in air, an anesthetic effect can slowly be achieved in 15-20 minutes of breathing approximately 15-20 ...
Hetzler RK, Knowlton RG, Somani SM, Brown DD, Perkins RM (January 1990). "Effect of paraxanthine on FFA mobilization after ...
1993). "Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory ... Luteolin • Mesembrin • Piklamilast • Roflumilast • Rolipram • Ro20-1724 • RPL-554 • YM-976 ...
Ben Kimmelman, Captain, 28th Infantry: The assumptions were that this would have some kind of cathartic effect, the sodium ...
When assayed in mice, repeated exposure to MDPV causes not only an anxiogenic effect but also increased aggressive behaviour, a ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ... On October 17, 2011, an Ohio law banning synthetic drugs took effect barring selling and/or possession of "any material, ... compound, mixture, or preparation that contains any quantity of the following substances having a stimulant effect on the ...
This adverse effect is not unique to zolpidem but also occurs with other hypnotic drugs. Caution should be exercised by motor ... Like zaleplon, zolpidem may increase slow wave sleep but cause no effect on stage 2 sleep.[43] A meta-analysis that compared ... Perrais D, Ropert N (January 1999). "Effect of zolpidem on miniature IPSCs and occupancy of postsynaptic GABAA receptors in ... Zolpidem has also been studied in persistent vegetative states with unclear effect.[65] A 2017 systematic review concluded that ...
... a new 5-HT reuptake blocker with particular emphasis on the side-effect profile of the 5-HT-uptake inhibiting drugs". ... DAT enhancers: Luteolin. *DAT modulators: Agonist-like: SoRI-9804. *SoRI-20040; Antagonist-like: SoRI-20041 ...
The effect of dihydrotestosterone (androstanolone) on clinical course and hormonal excretion". Cancer. 8 (1): 82-6. doi:10.1002 ... The effect of dihydrotestosterone (Androstanolone) on clinical course and hormonal excretion". Cancer. 8 (1): 82-86. doi: ... Kennedy BJ (1955). "The effect of stanolone in the treatment of advanced breast cancer". Cancer. 8 (3): 488-97. doi:10.1002/ ... Androstanolone esters act as prodrugs of androstanolone in the body and have a long-lasting depot effect when given via ...
... α-Pinene in particular is thought to reduce the memory deficits commonly reported as a side-effect of THC consumption. It ...
central nervous system stimulatory effect mainly on the medullary respiratory center.. The main therapeutic uses of ... Some lipid-based formulations of theophylline can result in toxic theophylline levels when taken with fatty meals, an effect ... an effect mediated via histone deacetylase-2 (HDAC2). Once deacetylated, DNA is repackaged so that the promoter regions of ...
... but does not produce amnesia and blocks the amnestic effect of diazepam, reflecting its different subtype affinity compared to ...
... has no effect on intracellular calcium stores, but rather, does not allow the entry of Ca2+ after intracellular stores ... Studies of the effect of several alkaloids in mice, including glaucine, demonstrate anticonvulsant and antinociceptive ... and a hallucinogenic effect characterised by colourful visual images,[7][8] and has been detected as a novel psychoactive drug. ...
... and no evidence for its effect on testosterone levels.[4] In 2016, the US Food and Drug Administration did not recommend ... there was no evidence to support any effect of oral chrysin on testosterone levels,[4] or an any disease-modifying activity ...
Luteolin, Apigenin, Tangeritin Flavonol. or. 3-hydroxyflavone 3-hydroxy-2-phenylchromen-4-one ✓ ✗ Quercetin, Kaempferol, ... However, population-based studies have failed to show a strong beneficial effect,[1][49] which might be due to the considerably ...
Regular users build up a physical tolerance, requiring larger doses for the same effect. ...
A diet rich in the plant compound luteolin could reduce age-related inflammation in the brain, according to a new study in the ... Now, older studies have shown that luteolin has anti-inflammatory effects in the body. However, this new look is the first to ... Luteolin was preventing inflammation. Later, they tested this idea on mice, fed either a control diet or a luteolin- ... Starting to forget things? Remember this word: "luteolin.". A diet rich in the plant compound luteolin could reduce age-related ...
Sari, Hafize Ayla; Ekinci, Raci (2017): The effect of ultrasound application and addition of leaves in the malaxation of olive ... The composition of phenolic compounds in olive leaves includes oleurosides (oleuropein, verbascoside), flavones (luteolin, ... The extreme environmental conditions in the "hot spot" zone of the ultrasonic cavitation have various effects on the plant ... Olive leaf extracts have anti-inflammatory effects and have been found to improve chronic diseases (e.g. diabetes, arthritis), ...
Studies have shown that luteolin possesses beneficial neuroprotective effects both in vitro and in vivo. It also has ... 7. Luteolin. Luteolin is a common flavonoid abundantly present in several plant products, including broccoli, pepper, thyme, ... The COVID-19 ( CO stands for corona, VI for virus, and D for disease ) pandemic has affected the entire world. With the ... above also studied other compounds and at number 3 on the list as those that has the potential to block the virus was Luteolin. ...
Luteolin has anti-oxidant and anti-inflammatory effects which can reduce the effects of multiple sclerosis, Luteolin has anti- ... Luteolin:. Luteolin interferes with nearly all types of cancer cells.. It inhibits the growth of new blood vessels in tumors, ... Luteolin is also an anti-inflammatory, antioxidant, prevents UVB-induced skin aging, luteolin can be used in the prevention and ... oxidant and anti-inflammatory effects which can reduce the effects of multiple sclerosis ...
Luteolin. Luteolin is a flavone with anti-depressant effects that works in part by impacting GABA levels in the brain. It also ... The effects caused by Valerian root can take 3-4 weeks to become noticeable. This herb has an effect on serotonin levels and ... At lower doses, the anti-addiction effects are less evident and at higher doses, the effects of Huperizine A may cause negative ... Valerian has an effect on the autonomic nervous system that causes it to not only reduce digestive cramping, but also spasms in ...
... not only because it can affect your appetite and will-power, but also because it can raise your blood sugar. How? Adrenaline. ... Quercetin and Luteolin as Endocrine Disruptors January 21, 2021 * How psychological stress affects mast cells October 31, 2020 ... As you may have experienced, stress makes it harder to lose weight-not only because it can affect your appetite and will-power ...
Quercetin and Luteolin as Endocrine Disruptors January 21, 2021 * How psychological stress affects mast cells October 31, 2020 ...
Quercetin and Luteolin as Endocrine Disruptors January 21, 2021 * How psychological stress affects mast cells October 31, 2020 ...
Quercetin and Luteolin as Endocrine Disruptors January 21, 2021 * How psychological stress affects mast cells October 31, 2020 ...
Luteolin has been shown to have pro-testosterone effects by reducing enzyme activities that convert testosterone to other ... Side effects. The high quality ingredients in Testo Lab Pro gives some reassurance that side effects can be minimal but it ... Unwanted side effects could happen if you body doesnt react well to one of the ingredients so we always recommend you discuss ... Luteolin from Orange extract. This is a rare ingredient to find in a testosterone booster. ...
Natural Protection from Apigenin Luteolin Curcumin and Ginger o Ultraviolet Radiation and Skin Aging (Photoaging) The most ... Anti-carcinogenic effects of the flavonoid luteolin. Molecules. 2008 Oct 22;13(10):2628-51.. (15) Arbiser JL, et al. Fisetin: a ... Luteolin and Apigenin Luteolin and apigenin have been shown as skin protectors from harmful UV radiation in many research ... In another study involving mice and cell cultures, luteolin inhibited the incidence of UVB-induced skin cancer.(2). • Luteolin ...
Short term fasting (3-7days) could show similar effects like caloric restriction. These are things Ill try.. Some people think ... It is a combination of luteolin and piperlongumine.. Posted by: Ignatius Turchi at April 25th, 2021 12:08 PM Cancel reply. Name ...
Hwang and his colleagues new mechanistic new mechanistic explanation of how luteolin exerts its anti-inflammatory effects offer ... Of the six compounds luteolin was the most effective inhibitor of TBK1. Luteolin is already known to have anti-inflammatory ... Haiti, and how to to provide provide a long term side effects of kamagra gold and only deal.. Kamagra Oral Jelly Detail ... Pay with paypal method side effects yahoo si te perdoret kamagra u apotekama bih cheap polo uk.. Kamagra oral jelly is a ...
However, have you ever considered what effects your diet has on various aspects of your health? ... This effect occurs because apples contain a ton of fiber. Fiber causes you to chew more thoroughly to break it down. During ... Celery contains a substance called luteolin, which calms this inflammation. 2. Apples. Maybe youve snacked on a McIntosh and ... However, have you ever considered what effects your diet has on various aspects of your health? One place where vegan eating ...
The natural treatment can also be applied by massaging the temples, for a soothing and refreshing effect. ... Edelweiss - very rich in antioxidants and contains chlorogenic acid and luteolin ; exceptional protecting, repairing and ... It has anti-oxidant ; antibacterial, calming and resistance-strengthening effects, protecting and soothing the skin ...
Luteolin is a flavone antioxidant in artichoke and artichoke extract, and a range of other plants with medicinal properties. ... Metabolic management (anti-diabetic effects). Another way artichoke extract is good for high blood pressure is via metabolic ... Research shows luteolin activates enzymatic reactions that trigger the production of nitric oxide. Nitric oxide acts as a cell ... Artichoke is a prebiotic with positive effects on beneficial gut bacteria. Research shows daily consumption of a very-long- ...
In herbal terms, dandelion root is considered to be both a choleretic herb (affects the liver) and a cholagogue (affects the ... Furthermore, they are rich in antioxidants like vitamin-C and Luteolin, which supports and maintains bone health at all ages. ... Use it on face skin affected with acne. As kids, we used to pick them and make a wish for good luck as we blew the dandelion ... They are also rich in antioxidants, which helps reduce the effects of ageing. It can even remove cystic acne, and share same ...
... luteolin, stigmasterol, beta-sitosterol, and kaempferol, exert a regulatory effect on 2019-nCoV [Figure 1], [Figure 2] and [ ... effects and inhibits coronavirus 3a channel protein to inhibit virus release.[11] Luteolin can downregulate the expression of ... luteolin, and kaempferol being the major three. The components possibly affect 151 signaling pathways, including AGE-RAGE, TNF ... subsequently increasing their cytolytic effect; IL-4 is a multi-effect cytokine that prolongs the lifespan of T- and B-cells ...
However, there have been few studies regarding the effects of manuka honey on bone metabolism and gut microflora. This study ... These results suggest that the MHCP expressed prebiotic effects, which might reduce bone resorption in OVX mice. ... Honey has antimicrobial, antitumor, antioxidant, and anti-inflammatory effects. ... investigated the effects of manuka honey combined with α-cyclodextrin, Manuka Honey with CyclopowerTM (MHCP) on bone metabolism ...
... affect affected after again aimed alabama alternative ambari america american anchor angeles animals ankle anticipated ... This is because the leaves have excessive ranges of bioactive compounds corresponding to apigenin, luteolin, and kaempferol. ... A 2019 examine suggested that celery leaves affect cytokines, which are immune system messenger molecules responsible for anti- ... effect effective efficient eighty electrolytes element elements eleven ellen elliptical ellipticals embiids employers energy ...
LC-MS/MS analyses revealed the presence and quantities of caffeic acid, luteolin rutin and coumaric acid. Cytotoxic effects of ... The Effect of Salvia Absconditiflora extract on the gene expression of GSTO1 and GSTZ1 in MCF-7 and MDA-MB-231 cells. Download ... Effects of S.absconditiflora water extract on the expression of glutathione-S-transferases (GSTs) in MCF-7 and MDA-MB-231 cells ... N. D. Hisarlı, "The Effect of Salvia Absconditiflora extract on the gene expression of GSTO1 and GSTZ1 in MCF-7 and MDA-MB-231 ...
In particular, luteolin has been shown to help our bodies fight free radical damage, and to inhibit the effects of certain ... A long list of powerful antioxidant phytonutrients, such as polyacetylene and luteolin make celery an anti-inflammatory ...
Ameliorative effects of luteolin, a therapeutic phytochemical, against endometriosis progression in vitro and in vivo Mar 3, ... Effect of herb-partitioned moxibustion (HPM) on pain and quality of life in women with endometriosis: a protocol for a ... The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory ... Effects of Sulawesi Propolis Extract on Lesion Growth, Apoptotic and Inflammatory Activity of the Rat Endometriosis Tissue May ...
Some studies have shown that thyme exhibits anti-inflammatory activity due to the presence of rosemarinic acid and luteolin. ... Soothing effects on the nervous system The herbal infusion may help in the management of depression, anxiety, and mental ... Certain respiratory illnesses caused by infections such as bronchitis are treatable due to its antibacterial effects. Improves ... honey for taste Safety and Precautions Side effects Having it as a part of a regular diet does not lead to any adverse effects ...
... whereas the effect is larger for quercetin and luteolin. For sign in to like videos, comment, and subscribe. Results: two focus ... Substitution at position c3 by the oh group has almost no effect on lambda max for taxifolin and eriodictyol, ...
Flavonoids Apigenin, luteolin, luteolin-7-glucoside, quercetin, quercitrin, kaempferol and glycosides . (3) ... A hypotensive effect in anaesthetised cats has been documented for an agrimony extract given by intravenous injection ; blood ... 16 Hsu F-L, Cheng J-T. Investigation in rats of the antihyperglycaemic effect of plant extracts used in Taiwan for the ... Silicic acid, traces of essential oil, and the flavonoids luteolin and apigenin 7-O-β-D-glucosides are present. 4 Organic acids ...
Luteolin was the most abundant phenolic compound and its concentration decreased from 268.65 +/- 5.428 to 93.57 +/- 0.541 ppm ... It seemed effect of filtration was more obvious on total phenolic contents. This study was good practice for producing premium ... Effects Of Filtration Process And Storage Time On The Chemical Changes And Sensory Properties Of Olive Oil Extracted From ... Filtration had no detectable effect on fatty acid profile. Filtered sample had higher total phenols (407.64 +/- 4.051 ppm) and ...
Flavonoids (hesperidin, naringin, luteolin, and ferulic acid) are also nice active compounds with possible antioxidant, anti- ... Variety of possible effects is smart, but even if everything is right, it is usually as! No introduction as one of those things ... Some of them (namely hesperidin and luteolin) might even have skin brightening activity by inhibiting tyrosinase, the famous ... "time-release AHA effect" and reduces the irritation associated with AHAs. The three of them is called AquaCell and is claimed ...
Most cannabinoids affect our neurochemistry by activating neurotransmitter receptors, and by doing so they can calm down our ... The most bioactive cannabis phenols are flavonoids that are found in other edible plants, including apigenin, luteolin, ... With over 100 known cannabinoids contained in cannabis, these effects are far-reaching, and the science is so new that we are ... As with terpenes, phenols often affect us through their aromas. Once they have been absorbed by our bodies, they begin to fight ...
Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. European Journal of Pharmacology. Volume ... Látka jménem luteolin izolovaná ze šišáku bajkalského zároveň zásadním způsobem ovlivňuje apoptózu neboli programovanou ... Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. European Journal of Pharmacology. Volume ... Hepatoprotective effect of the fractions of Ban-zhi-lian on experimental liver injuries in rats. J Ethnopharmacol. 1997 May;56( ...
  • Here, we evaluated the effects of eight flavonoids on the tumour cell proliferation, cellular protein phosphorylation, and matrix metalloproteinase (MMPs) secretion. (nih.gov)
  • 2. Of the flavonoids examined, luteolin (Lu) and quercetin (Qu) were the two most potent agents, and significantly inhibited A431 cell proliferation with IC50 values of 19 and 21 micronM, respectively. (nih.gov)
  • 7. Examination of the relationship between the chemical structure and inhibitory effects of eight flavonoids reveal that the double bond between C2 and C3 in ring C and the OH groups on C3' and C4' in ring B are critical for the biological activities. (nih.gov)
  • Certain flavonoids, such as luteolin, have anti-oxidant and anti-inflammatory effects, including inhibition of activated peripheral blood leukocytes from MS patients. (longevityunlocked.com)
  • Moreover, luteolin and structurally similar flavonoids can inhibit experimental allergic allergic encephalomyelitis (EAE). (longevityunlocked.com)
  • Flavonoids such as Quercetin and Luteolin have potent anti-oxidant and anti-inflammatory activity. (longevityunlocked.com)
  • Koosha S, Alshawsh MA, Looi CY, Seyedan A, Mohamed Z. An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer. (medsci.org)
  • We also describe the signaling pathways affected by flavonoids that have been found to be involved in CRC. (medsci.org)
  • Anti-inflammatory effects of flavonoids in neurodegenerative disorders. (semanticscholar.org)
  • Figure 1 shows the molecular structure of the flavonoids employed: luteolin, quercetin, genistein and quercetagetin. (biomedcentral.com)
  • We show that two flavonoids, luteolin and quercetin, are promiscuous endocrine disruptors. (springer.com)
  • We also show an alternative orientation of luteolin within the TBS which could represent a general mode of binding of flavonoids to TTR and is of importance concerning the future design of tetramer stabilizing drugs. (sigmaaldrich.com)
  • Luteolin is a very typical kind of natural flavonoid and belongs to weak acidic tetrahydroxy flavonoids. (chemicalbook.com)
  • In this review, we discuss host and microbiota-mediated metabolism of flavonoids and the potential mechanisms by which flavonoids can exert protective effects against colon tumorigenesis, including regulation of signaling pathways involved in apoptosis, cellular proliferation, and inflammation and modulation of the gut microbiome. (mdpi.com)
  • Like other flavonoids, luteolin as shown in Figure 1 (3, 4, 5, 7- tetrahydroxyflavone), is often found in the various vegetables and fruit materials in the form of glycosides and has contributed as the antioxidant property in different diseases. (alliedacademies.org)
  • Luteolin is one of the few flavonoids that is not readily absorbed by the body. (naturalpedia.com)
  • His study explored the effects of the flavonoids luteolin and querceti. (bio-medicine.org)
  • Flavonoids tested in the study affected the endocrine system in ways that in one case promoted cancer and in another repressed it. (bio-medicine.org)
  • His study explored the effects of the flavonoids luteolin and quercetin on cell models of breast and endometrial cancer. (bio-medicine.org)
  • Detrimental effects of flavonoids are not without precedent. (bio-medicine.org)
  • Luteolin shown in Figure 1 is one of the important dietary flavonoids which are commonly present in various fruits and vegetables. (alliedacademies.org)
  • Here, we report that flavonoids have a beneficial effect in acute and chronic experimental allergic encephalomyelitis (EAE). (rupress.org)
  • Both in vitro and in vivo studies report that flavonoids and their metal ion complexes exert pleiotropic effects on tumor promotion and progression. (intechopen.com)
  • The credit goes to the flavonoids quercetin, genistein, and luteolin. (naturalpedia.com)
  • Effects of Luteolin and Other Flavonoids on IgE-mediated Allergic Reactions. (nii.ac.jp)
  • De Matouschek 1991 The flavonoids luteolin and 6-C-glucoside have also been isolated. (drugs.com)
  • It contains antioxidants from flavonoids, such as quercetin and luteolin, and chamazulene(an essential oil). (selfgrowth.com)
  • When measured against 27 other flavonoids, luteolin provided the best DNA protection. (makemeheal.com)
  • Antitussive properties contains flavonoids, such as luteolin, pectin fiber furthermore having demulcent and antitussive effect. (botanical-online.com)
  • some articles mention that flavonoids contained in the fruits of cactus have protective effect on the brain, being a suitable food for memory and prevent degenerative diseases like Alzheimer's . (botanical-online.com)
  • Celery contains the flavonoids luteolin and apigenin, which researchers from the University of Illinois believe could have pancreatic cancer-killing capabilities. (healthcentral.com)
  • Some recent studies suggest flavonoids in passionflower are primarily responsible for its relaxing effects however, more research is needed. (nutrametrix.com)
  • Our results suggest that luteolin could be a potent anti-angiogenic agent for retinal neovascularization, which is related to anti-oxidative activity to block ROS production and to subsequently suppress VEGF expression and the pro-angiogenic effect of VEGF. (arvojournals.org)
  • The present findings suggest that luteolin ameliorates D-GalN/LPS-induced liver injury and that this protection is likely due to inhibition of the extrinsic and intrinsic apoptotic pathways. (sparrho.com)
  • In conclusion, the results suggest that luteolin can inhibit the proliferation of breast cancer cells , and suppress the expression of Bcl-2. (bvsalud.org)
  • although this does not in any way suggest that luteolin does not offer any health benefits. (naturalpedia.com)
  • These results suggest that luteolin is a genuinely active constituent which is accountable for the oral effects of perilla. (go.jp)
  • Furthermore, studies on animals suggest that luteolin could enhance the potency of chemotherapy drugs that act on cancer cells while reducing the toxic effects of these drugs on the body. (medicalnewstoday.com)
  • The present investigation shows the potential of luteolin as a stabilizer of TTR in vivo. (sigmaaldrich.com)
  • The antioxidant potential of luteolin was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. (nih.gov)
  • Owing to the excellent anti-inflammatory, anticancer, antioxidant and free radical scavenging potential of luteolin, we assume that it might possess the protective effect against the DCM. (alliedacademies.org)
  • The promising anticancer potential of luteolin can be effectively utilized in future for anticancer drug development. (alliedacademies.org)
  • 5. The addition of EGF only marginally diminished the inhibitory effect of luteolin and quercetin on the growth rate of A431 cells, treatment of cellular proteins with EGF and luteolin or quercetin greatly reduced protein phosphorylation, indicating Lu and Qu may act effectively to inhibit a wide range of protein kinases, including EGFR tyrosine kinase. (nih.gov)
  • Innovative ways of delivering select flavonoid combinations would be required to assure sufficient plasma levels, especially if luteolin can inhibit brain inflammation. (longevityunlocked.com)
  • By using a high concentration of luteolin in the blood, we were better able to inhibit the growth of cancer cells. (redorbit.com)
  • Preliminary studies have found that luteolin can inhibit the apoptosis of the angiogenesis induced cell, affect the tumor growth in animal models, reduce the tumor growth and also improve the cytotoxicity of certain anti-cancer drugs on the tumor cell, indicating that luteolin could be potential cancer chemo-preventive drugs and chemotherapy drugs. (chemicalbook.com)
  • Luteolin has been found to inhibit CRC cells proliferation, induce cells apoptosis and cell cycle perturbation ( 13 - 15 ). (spandidos-publications.com)
  • Liu et al also reported that luteolin was able to inhibit CRC cells epithelial to mesenchymal transition by suppressing CREB1 expression ( 16 ). (spandidos-publications.com)
  • Previously, we described the flavone luteolin and especially the flavonol quercetin as being potent antioxidants that inhibit myelin phagocytosis by macrophages ( 7 ). (rupress.org)
  • It was reported that luteolin, extracted from Chinese herbs, could potently inhibit influenza virus replication in vitro. (springermedizin.de)
  • One favorable mechanism of luteolin is its ability to inhibit oxidative damage to cellular DNA. (makemeheal.com)
  • The luteolin significant inhibited RPMI-8226 cell proliferation in a dose-dependent manner. (greenmedinfo.com)
  • 8. This study demonstrates that the inhibitory effects of Lu and Qu, and the stimulatory effects of EGF, on tumour cell proliferation, cellular protein phosphorylation, and MMP secretion may be mediated at least partly through EGFR. (nih.gov)
  • Luteolin effectively inhibited cell proliferation and induced apoptosis in HER2-overexpressing cancer cells. (aacrjournals.org)
  • We have also measured how different concentrations of luteolin effects on cell proliferation of HepG2 over 48 h of window. (alliedacademies.org)
  • Luteolin Decreases EGFR-Mediated Cell Proliferation and Induces Apoptosis in Glioblastoma Cell Lines. (cedarville.edu)
  • Luteolin inhibits the proliferation of RPMI-8226 cells. (greenmedinfo.com)
  • Luteolin inhibits the proliferation of RPMI-8226 cells by inducing the pathways of both apoptosis and autophagy, moreover the actions of apoptosis and autophagy are interactive or/and promotive each other. (greenmedinfo.com)
  • Luteolin also inhibits mast cells, as well as mast cell-dependent T cell activation, recently implicated in MS pathogenesis. (longevityunlocked.com)
  • Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell dependent stimulation of Jurkat T cells. (longevityunlocked.com)
  • Luteolin inhibits the invasion,migration and adhesion ability of human hepatocelluar carcinoma HepG2 cells .The mechanism may be related to the regulatory effects of luteolin on epithelial-mesenchymal transition . (bvsalud.org)
  • We believe dietary luteolin accesses the brain and inhibits or reduces activation of microglial cells and the inflammatory cytokines they produce. (lifeextension.com)
  • Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p. (sigmaaldrich.com)
  • To test this hypothesis, we showed that the combined use of luteolin and mTOR inhibitor rapamycin prevented low doses of luteolin from inducing p21 expression, and HER2-overexpressing cancer cells would be sensitized toward luteolin-induced apoptosis. (aacrjournals.org)
  • Apoptotic assays revealed that the multi-heavy metal mixture induced HL7702 cell apoptosis in a dose-dependent manner, which was significantly inhibited by 20 µM luteolin. (spandidos-publications.com)
  • The present results suggested luteolin exerts its inhibitory effects of on multi-heavy metal mixture induced cell apoptosis through downregulation of the ROS-activated mitochondrial pathway. (spandidos-publications.com)
  • With the deepening of the study on luteolin, researchers have found that it have anti-cancer activities including inhibiting the proliferation of tumor cell, inducing the apoptosis of tumor cells as well as sensitizing anti-cancer drugs. (chemicalbook.com)
  • In prostate cancer cells, luteolin treatment inhibited prostate cancer cells proliferation and induced apoptosis through downregulation of miR-301 by triggering DEDD2 expression ( 25 ). (spandidos-publications.com)
  • Luteolin also inhibited the tumorigenesis and induced the apoptosis of non-small cell lung cancer cells by upregulation of miR-34a-5p by targeting MDM4 ( 26 ). (spandidos-publications.com)
  • And LUT decreased miR-208b-3p expression and apoptosis caused by I/R. However, overexpression of miR-208b-3p further aggravated the changes caused by I/R and blocked all the effects of LUT. (sigmaaldrich.com)
  • Next we studied the underlying mechanism of luteolin action, and found its inducing apoptosis of HepG2 cell, apoptosis was monitored based on propidium iodide internalization assay using flow cytometer (FACS). (alliedacademies.org)
  • Altogether our result clearly showed the details mechanistic pathway by which luteolin is inducing apoptosis in HepG2. (alliedacademies.org)
  • MH exhibited profound inhibitory effects on cellular growth by reducing the proliferation ability, inducing apoptosis and arresting the cell cycle in a dose-dependent manner. (rsc.org)
  • To assess the effect and explore the fundamental mechanism of luteolin, we infected several cell lines with two subtypes of influenza A virus (IAV), including A/Jiangxi/312/2006 (H3N2) and A/Fort Monmouth/1/1947 (H1N1) and demonstrated that luteolin suppressed the replication of IAV by cytopathic effect reduction method, qRT-PCR, immunofluorescence and Western blot assays. (springermedizin.de)
  • Having multiple biological effects such as anti-inflammation, anti-allergy and anticancer, luteolin functions as either an antioxidant or a pro-oxidant biochemically. (longevityunlocked.com)
  • Physicochemical properties and antioxidant activities of luteolin-phospholipid complex. (semanticscholar.org)
  • The study, published today in Cancer Prevention Research, a journal of the American Association for Cancer Research, involved the use of microscopic amounts of the naturally occurring antioxidant, luteolin, that were encapsulated in a water-soluble polymer. (redorbit.com)
  • Similarly to quercetin, luteolin is an polyphenol antioxidant that may have a variety of beneficial health effects ( 4 , 12 ). (healthline.com)
  • Luteolin treatment abated selenite induced oxidative stress and cataractogenesis by maintaining antioxidant status, reducing ROS generation and lipid peroxidation in the lens. (nih.gov)
  • These finding demonstrated the anticataractogenic effect of luteolin by virtue of its antioxidant property, which has been reported in this paper for the first time. (nih.gov)
  • Salvia plants are traditionally noted for their antioxidant effects and ability to enhance 'head and brain' function, improve memory, quicken the senses, and delay age-associated cognitive decline [ 1 ]. (springer.com)
  • Luteolin is a flavinoid with strong antioxidant properties found in the leaves of certian plants. (patientslikeme.com)
  • Antioxidant effect of doxycycline decreases MMP activity and blood pressure in SHR. (biomedsearch.com)
  • In this study, we hypothesized that doxycycline (a MMP inhibitor) could exert antioxidant effects, reverse establish vascular remodeling, and lower blood pressure in spontaneously hypertensive rats (SHR). (biomedsearch.com)
  • Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol, with particular attention on their antioxidant activity. (biomedcentral.com)
  • Quercetin is a bioflavonoid found in many plants and grains, known for its positive effects on the immune system and for its antioxidant properties. (versus.com)
  • In addition, 20 µM luteolin had a significant inhibitory effect on multi-heavy metal mixture-induced cleavage of caspase-9, caspase-3 and poly(adenosine diphosphate-ribose) polymerase-1 protein. (spandidos-publications.com)
  • This inhibitory effect can also explain why many doctors suggest using luteolin to alleviate symptoms of multiple sclerosis. (naturalpedia.com)
  • Inhibitory effect of the Pseudobrickellia brasiliensis (Spreng) R.M. King & H. Rob. (thefreelibrary.com)
  • The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. (rsc.org)
  • It was found that luteolin reversibly inhibited XO in a competitive manner with inhibition constant (Ki) value of (2.38±0.05)×10(-6) mol l(-1). (nih.gov)
  • The flavone luteolin has numerous useful actions that include: anti-oxidant, anti-inflammatory, microglia inhibition, neuroprotection, and memory increase. (frontiersin.org)
  • Examination of the Akt/mammalian target of rapamycin (mTOR) signaling revealed that this signaling was only transiently inhibited by low doses of luteolin, which suggested that the inability to cause sustained Akt/mTOR inhibition may contribute to p21 induction and provide a survival advantage to HER2-overexpressing cancer cells. (aacrjournals.org)
  • In nude mice with xenografted SKOV3.ip1-induced tumors, luteolin significantly inhibited HER2 expression and tumor growth in a dose-dependent manner, and rapamycin further enhanced the effect of luteolin with a concomitant p21 inhibition. (aacrjournals.org)
  • miR‑384 inhibition and PTN overexpression partially reversed the inhibition of HT‑29 cells migration and invasion induced by luteolin. (spandidos-publications.com)
  • Among the isolated compounds, only luteolin showed in vivo activity: inhibition of serum tumor necrosis factor-α production, inhibition of arachidonic acid-induced ear edema, inhibition of 12- O -tetradecanoylphorbol-13-acetate-induced ear edema and inhibition of oxazolone-induced allergic edema. (go.jp)
  • Replacement of 14 C-acetate by 14 C-mevalonate largely omitted the inhibiting effect of artichoke extracts indicating an inhibition at the level of hydroxymethylglutaryl-CoA-reductase. (aspetjournals.org)
  • However, no direct inhibition of this enzyme could be detected and no other enzymic steps later in the biosynthetic pathway for cholesterol seemed to be affected. (aspetjournals.org)
  • Screening of several known constituents of artichoke extracts revealed that cynaroside and particularly its aglycone luteolin were mainly responsible for inhibition, whereas chlorogenic acid was much less effective and caffeic acid, cynarin and other dicaffeoylquinic acids were without significant influence. (aspetjournals.org)
  • Effects of the flavone luteolin, isolated. (ju.edu.jo)
  • Luteolin (3′,4′,5,7 tetrahydroxyflavone) is an important flavone present in broccoli, pepper, thyme and celery and naturally found in a glycosylated form. (biomedcentral.com)
  • The plant-derived luteolin analogue cynaroside has a glucoside group in position 7 of the flavone A-ring and as opposed to luteolin is unable to stabilize TTR tetramers and thus prevents a cytotoxic effect. (sigmaaldrich.com)
  • Observations propose that luteolin could be an anticancer agent for various cancers. (longevityunlocked.com)
  • Two chemicals, apigenin and luteolin which are anticancer. (abovetopsecret.com)
  • Luteolin (3,4,5,7‑tetrahydroxyflavone) is a natural flavonoid that has been found to exhibit anticancer properties in certain types of cancers. (spandidos-publications.com)
  • The present study demonstrated that luteolin exerts anticancer effects against CRC cells by modulating PTN via miR‑384 expression suggested that PTN may serve as a promising candidate for therapeutic applications in CRC treatment. (spandidos-publications.com)
  • Product Name: peanut shell extract luteolin 98% Latin Name: Arachis hypogaea L. (trader-china.com)
  • Luteolin is one of the major components of celery and green peppers, its inhibitory activity on XO and their interaction mechanism were evaluated by multispectroscopic methods, coupled with molecular simulation. (nih.gov)
  • Green leaves such as parsley and celery top the list of luteolin-rich foods. (selfhacked.com)
  • Luteolin is found in carrots, rosemary, celery and other foods. (lifeextension.com)
  • Luteolin is the pigment that gives foods such as celery and parsley their lovely, green color. (naturalpedia.com)
  • A 2014 study investigated the effects of celery leaf extract on the cholesterol levels of rats fed a high-fat diet. (medicalnewstoday.com)
  • Luteolin (luteolin) is a natural flavonoid found in many plants. (alibaba.com)
  • Luteolin, a flavonoid found in a variety of plants, offers a means of curbing mast cell activation in the brain. (drhoffman.com)
  • Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. (semanticscholar.org)
  • Snopes says it's bunk and that they 'were not able to locate any published research indicating dandelion root affirmatively demonstrated an anti-cancer effect in humans. (abovetopsecret.com)
  • This led us to postulate that a long-term daily exposure to low doses of B through diet might be safe and sufficient to produce cancer chemopreventive effect in humans. (degruyter.com)
  • These effects have not been studied in humans yet. (pbhfoundation.org)
  • However, scientists still need to do further studies to confirm whether luteolin has similar anti-allergy effects in humans. (medicalnewstoday.com)
  • flavonoid, apigenin, and luteolin are found in parsley at a greater percentage. (differencebetween.net)
  • Despite both coriander and parsley being sources of vitamins and various nutrients, they have some effects on the health of individuals, which is exhibited in different terms. (differencebetween.net)
  • However, studies indicate that excessive consumption of parsley is likely to cause uterotonic effects, which causes it to be barred or avoided by pregnant women. (differencebetween.net)
  • In this work, we show that luteolin effectively attenuates the cytotoxic response to TTR in cultured neuronal cells and rescues the phenotype of a Drosophila melanogaster model of FAP. (sigmaaldrich.com)
  • Nordeen and colleagues show that luteolin blocks some of the endocrine. (bio-medicine.org)
  • Plants sources rich in luteolin have appeared in Chinese traditional medicine for treating many diseases such as hypertension, inflammatory disorders, and cancer. (longevityunlocked.com)
  • Plants rich in luteolin content are often used as a traditional Chinese medicine for treatment of disease. (chemicalbook.com)
  • Scientists call these two compounds apigenin and luteolin . (medicalnewstoday.com)
  • Research shows that apigenin and luteolin reduce inflammation and may help treat a range of inflammatory diseases. (medicalnewstoday.com)
  • Finally, given these potent anti-inflammatory properties of luteolin, as well as the inverse relationship between flavonoid intake and cognitive decline in older persons and aged animals reported by others, we explored whether dietary supplementation of luteolin can ameliorate age-related deficits in spatial working memory and reduce inflammatory molecules in aged brain. (illinois.edu)
  • A luteolin and phospholipid complex was prepared to improve the lipophilic properties of luteolin. (semanticscholar.org)
  • Effects of Luteolin on Proliferation and Programmed Cell Death of Human Multiple Myeloma Cell RPMI-8226]. (greenmedinfo.com)
  • To investigate the effect of Luteolin on proliferation and cell death of human multiple myeloma cell line RPMI-8226 and its mechanisms. (greenmedinfo.com)
  • The results showed luteolin inhibited MCF-7 cells proliferation in a dose - and time -dependent manner, and the expression of Bcl-2 protein was decreased. (bvsalud.org)
  • On the other hand, combined treatment with luteolin (Lut, 0.5 μ and quercetin (Que, 0.5 μ.M) profoundly decreased MDA-MB-231 proliferation by down-regulating α9-nAChR expression. (elsevier.com)
  • First, the effects of luteolin on CRC cells proliferation, migration and invasion were examined by CCK‑8, wound healing and Transwell assays, respectively. (spandidos-publications.com)
  • It was demonstrated that luteolin had no effects on CRC cells proliferation while inhibited cells migration and invasion both in vitro and in vivo. (spandidos-publications.com)
  • Herbal traditions around the globe use luteolin-rich plants to strengthen the immune system , relieve inflammation, and even combat cancer [ 1 , 2 ]. (selfhacked.com)
  • Luteolin is considered by some to be a supper nutrient as it helps reduce inflammation, and promotes nerve and muscle function. (longevityunlocked.com)
  • 3.Luteolin applied in pharmaceutical field, Luteolin can play the role of inflammation. (alibaba.com)
  • Rodney Johnson and his associates at the University of Illinois report in the October, 2010 issue of the Journal of Nutrition that the flavonoid luteolin helped reduce inflammation in the brains of aged mice, which restored memory to levels observed in younger animals. (lifeextension.com)
  • When we provided the old mice luteolin in the diet it reduced inflammation in the brain and at the same time restored working memory to what was seen in young cohorts," Dr Johnson stated. (lifeextension.com)
  • Salvia plants and their constituents can influence several biological mechanisms associated with cognition including their effects on amyloid-β, cholinergic activity, neurotrophins, oxidative stress, inflammation and anxiolytic/antidepressant behaviours. (springer.com)
  • Luteolin is often used as an additive treatment for brain damage caused by inflammation. (naturalpedia.com)
  • Luteolin treatment resulted in reduced inflammation and axonal damage in the CNS by preventing monocyte migration across the brain endothelium. (rupress.org)
  • Effects of NZ-107 on Airway Inflammation and Cell Activation in Guinea-Pigs. (nii.ac.jp)
  • A 2017 study investigated whether luteolin could reduce inflammation and lower allergic responses in mice with these conditions. (medicalnewstoday.com)
  • Results showed that giving the mice luteolin 30 minutes before exposing them to an allergen significantly reduced the levels of inflammation within their lungs and nasal passages. (medicalnewstoday.com)
  • A 2013 study investigated whether luteolin could reduce inflammation and protect against neurodegeneration in rodents with diabetic encephalopathy (DE). (medicalnewstoday.com)
  • This supplement does a really good job of helping you overcome all those toxic- and inflammation-related effects. (blogarama.com)
  • Luteolin also is thought to slow age-related memory loss by halting the release of molecules that cause brain inflammation. (healthcentral.com)
  • Researchers from the University of Illinois studied the effect of a luteolin diet on older mice, which have increased brain inflammation compared to young mice, and found that the mice on the luteolin diet performed better with memory tasks and had much lower inflammation levels. (healthcentral.com)
  • Manuka honey (MH) represents a good source of phenolic compounds such as luteolin, kaempferol, quercetin, gallic acid and syringic acid. (rsc.org)
  • Our previous study indicated that dietary luteolin (LU) could prevent the establishment of insulin resistance in mice fed a high-fat diet (HFD). (springermedizin.de)
  • Effect of diosmin administration in patients with chronic venous disorders on selected factors affecting angiogenesis. (greenmedinfo.com)
  • The purpose of the present study was to investigate the effect of luteolin on the angiogenesis and invasion of breast cancer cells . (bvsalud.org)
  • The chick chorioallantoic membrane model was used to assess the angiogenesis effect . (bvsalud.org)
  • Luteolin had a strong anti-angiogenesis of chick chorioallantoic membrane . (bvsalud.org)
  • Phytochylomicron as a dual nanocarrier for liver cancer targeting of luteolin: in vitro appraisal and pharmacodynamics. (semanticscholar.org)
  • Luteolin inhibited the invasion,migration and adhesion ability of HepG2 cells in vitro in a dose -dependent manner. (bvsalud.org)
  • Free radical mediated oxidative stress plays a crucial role in the pathogenesis of cataract and the present study was to determine the efficacy of luteolin in preventing selenite induced oxidative stress and cataractogenesis in vitro. (nih.gov)
  • Using the inhibitory activity of TNF-α production in vitro as the index for isolation, we searched the active constituents from PLE and isolated luteolin, rosmarinic acid and caffeic acid as active components. (go.jp)
  • The present review will describe the biological effects of oleuropein and hydroxytyrosol, with particular attention on the molecular mechanism underlying the protective action on cardiovascular and metabolic alterations, as demonstrated by in vitro and in vivo experimental studies performed with the isolated compounds. (biomedcentral.com)
  • While the toxic molecular mechanisms of different heavy metals are not identical, they have certain effects in common. (spandidos-publications.com)
  • In the present study, the role of luteolin and its underlying mechanisms were explored in colorectal cancer (CRC) cells. (spandidos-publications.com)
  • TNBC and some of the bioactive natural compounds known to be capable of having an effect. (canceractive.com)
  • But over the last decade, more and more research has been recorded showing how bioactive natural compounds have an effect in preventing and correcting breast cancer, and even with TNBC. (canceractive.com)
  • Now, increasingly, many bioactive compounds in nature are being shown to have positive effects. (canceractive.com)
  • Methylated luteolin analogs with increased activity and better bioavailability could be developed into effective treatments for neuropsychiatric disorders and brain "fog. (frontiersin.org)
  • In over-the-counter supplement form, the first compound, luteolin, is commonly recommended for the treatment of pediatric autism spectrum disorders. (bio-medicine.org)
  • But then in an endometrial cancer cell model, luteolin had two deleterious effects. (bio-medicine.org)
  • First, it acted like estrogen to directly stimulate cancer cell growth and second, by again blocking progesterone's action, luteolin disabled the brake that progesterone puts on estrogen-dependent endometrial cancer growth. (bio-medicine.org)
  • The effect of Luteolin on the growth of human multiple myeloma cell line RPMI-8226 was detected by CCK-8, and then the minimal effective concentration was determined and was used to treat RPMI-8226 cells. (greenmedinfo.com)
  • The effects of luteolin and chloroquine on expression of cleaved-caspase 3 and LC3 in RPMI8826 cells was detected by Western blot. (greenmedinfo.com)
  • The toxicity of luteolin was evaluated through modified 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay in human retinal microvascular endothelial cells (HRMECs) as well as TUNEL staining in the retina of C57BL/6J mice. (arvojournals.org)
  • Many studies have shown the antiproliferative actions of luteolin on cancer cells. (longevityunlocked.com)
  • However, the effects of luteolin on incursion of cancer cells remain unclear. (longevityunlocked.com)
  • 4.Luteolin can reduce the level of hepatic fibrosis and protect liver cells from damage. (alibaba.com)
  • Luteolin also shows potent anti-inflammatory activities by inhibiting nuclear factor kappa B (NFkB) signaling in immune cells. (semanticscholar.org)
  • Immunomodulatory Effects of Psyllium Extract on Helicobacter pylori Interaction With Gastric Epithelial Cells. (semanticscholar.org)
  • Compound A, a plant origin ligand of glucocorticoid receptors, increases regulatory T cells and M2 macrophages to attenuate experimental autoimmune neuritis with reduced side effects. (semanticscholar.org)
  • Luteolin-loaded phytosomes sensitize human breast carcinoma MDA-MB 231 cells to doxorubicin by suppressing Nrf2 mediated signalling. (semanticscholar.org)
  • To investigate the effects of luteolin on invasion,migration and adhesion of human hepatocelluar carcinoma HepG2 cells . (bvsalud.org)
  • HepG2 cells were cultured and treated with luteolin at 10 ,20 and 40 μmol/L respectively.The invasion capability was examined by cell invasion assay.The migration ability was examined by wound healing assay.The adhesion capability was measured by adhesion assay.The protein levels of E-cadherin , N-cadherin , vimentin and Snai1 were determined by Western blot analysis . (bvsalud.org)
  • Both α5- and α9-nAChR appear to be important molecular targets for Lut- and Que-induced antitumor effects in human breast cancer cells. (elsevier.com)
  • In the present study, the inhibitory effects of luteolin on the combined toxicity of multi-heavy metals (including zinc, manganese, lead, copper, cadmium, mercury, chromium and nickel) were investigated in HL7702 hepatocyte cells. (spandidos-publications.com)
  • Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells. (nih.gov)
  • When injected into mice the nano-luteolin inhibited growth of lung cancer and head and neck cancer cells. (redorbit.com)
  • The current research, funded by the National Institutes of Health, examined luteolin's effect in immune cells in the brain known as microglial cells, which produce inflammatory signaling molecules in response to infection. (lifeextension.com)
  • It's doing it by affecting the microglial cells. (lifeextension.com)
  • The study is the first to indicate that luteolin increases cognitive function by acting on the microglial cells. (lifeextension.com)
  • Different concentrations of B and D (0.29-290 μg/ml) and in various combinations (B:D ratio = 1:0, 1:1, 5:1, 1:5 and 0:1) were tested for cytotoxic effects against the three cancer cells. (degruyter.com)
  • Luteolin was found to upregulate miR‑384 and downregulate PTN expressions both in CRC cells and tissues. (spandidos-publications.com)
  • Zhou et al found that luteolin upregulated miR-34 expression in gastric cancer cells and upregulation of miR-34 enhanced the susceptibility of cells to luteolin ( 6 ). (spandidos-publications.com)
  • Thus, we hypothesized that miRNAs play significant roles during luteolin treatment in CRC cells and this has not yet been investigated. (spandidos-publications.com)
  • Mice studies have shown that luteolin was particularly efficient in reducing tumor growth in ovarian cancer cells. (naturalpedia.com)
  • Luteolin is a flavonoid and considered to be important for anti-cancer activity against many cancer cells. (alliedacademies.org)
  • In this study we checked luteolin activity against number of cell line and according to our screen mouse liver cancer cells (HepG2) is found to be most susceptible to its action. (alliedacademies.org)
  • Further investigation revealed that luteolin is causing extensive DNA degradation in HepG2 cells. (alliedacademies.org)
  • In this study, we investigated the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on UCP3 gene expression in C 2 C 12 muscle cells. (mdpi.com)
  • Lee M-S, Kim I-H, Kim Y. Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Uncoupling Protein 3 Gene Expression in C 2 C 12 Muscle Cells. (mdpi.com)
  • In the lab, luteolin was administered to human breast cancer cells and researchers used luteolin to observe the stem cell-like characteristics in the cancer cells. (doctorshealthpress.com)
  • The luteolin displayed its anti-tumor effects by shrinking the breast cancer cells. (doctorshealthpress.com)
  • According to a 2016 review , luteolin can halt the growth of some types of cancer cells in rodents. (medicalnewstoday.com)
  • Luteolin may also prevent cancer cells from invading other areas of the body, or 'metastasizing. (medicalnewstoday.com)
  • Chemoprotection of haematopoietic stem cells (HSCs) by gene therapeutic transfer of drug-resistance genes represents the encouraging approach to prevent myelosuppression, which is one of the most severe side effects in tumor therapy. (biomedsearch.com)
  • The aim of this work was to evaluate the chemopreventive effects of MH on human colon cancer HCT-116 and LoVo cells. (rsc.org)
  • The effects of different concentrations of Luteolin extract on prednisone/prednisolone metabolism indicated the enzyme activity of 11 β -HSD, so the production rate (pmol/min per mg protein) of metabolites was used to indicate enzyme activity. (hindawi.com)
  • Our results showed that oral administration of Luteolin significantly increased the gene and protein expressions of hepatic 11 β -HSD I and renal 11 β -HSD II, which may improve the efficacy and reduce the adverse drug effect of glucocorticoid in clinical application. (hindawi.com)
  • And while there's some room for cause-and-effect arguing in some of these, in others it seems clear that the primary event is protein aggregation . (sciencemag.org)
  • In addition, we found that luteolin suppressed coat protein I complex expression, which was related to influenza virus entry and endocytic pathway. (springermedizin.de)
  • Supplements containing healthy phytochemicals and botanical extracts have been proven to alleviate symptoms without negative side effects, and balance the immune system so it doesn't over-react to allergens. (smart-publications.com)
  • However, botanical extracts have been shown to provide relief to allergy sufferers, safely and naturally, without side effects. (smart-publications.com)
  • When properly harvested and processed, the following botanical extracts provide a synergistic effect to help control the common symptoms and causes of allergies by inhibiting histamine release and, more importantly, correcting immune system dysfunction. (smart-publications.com)
  • Additionally, these botanical extracts do not have unpleasant side-effects like drowsiness or dry mouth associated with pharmaceuticals. (smart-publications.com)
  • 2.Luteolin has anti-tumor effect. (alibaba.com)
  • Novel Low Immunosuppressive Derivatives of the Antitumor Drug Fluoropyrimidine, UK-21 and UK-25 : Effect on Delayed Type Hypersensitivity and Tumor Immunity. (nii.ac.jp)
  • Further research is required to examine the longer-term cognitive-enhancing effects of Salvia species on cognition, memory and the treatment of neurodegenerative diseases such as Alzheimer's disease. (springer.com)
  • The findings of the current study suggest that the luteolin might have a beneficial effect against DCM via improvement the Akt/GSK-3β signalling pathway. (alliedacademies.org)
  • Our previous study revealed that Eclipta prostrata (EP) affected the activity and expression of 11 β -HSD enzymes which might improve the efficacy and reduce the adverse drug effects of glucocorticoid in patients undergoing combinational therapy. (hindawi.com)
  • Efficacy of ultramicronized palmitoylethanolamide in burning mouth syndrome-affected patients. (greenmedinfo.com)
  • Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant. (mdpi.com)
  • This may subsequently influence the pharmacokinetic and pharmacodynamic properties of drugs, leading to their changed efficacy and undesired effects [ 5 , 6 ]. (mdpi.com)
  • There is a wealth of evidence that prove the efficacy of luteolin in cancer growth interference . (naturalpedia.com)
  • This allows manufacturers to market supplements without fully testing nutraceutical products for efficacy or potential side effects. (bio-medicine.org)
  • Deacetylation performed by HDAC molecules has the opposite effect. (wikipedia.org)
  • Anti-angiogenic activity of luteolin was evaluated by VEGF-induced migration and tube formation assay. (arvojournals.org)
  • An MTT assay demonstrated that 20 µM luteolin significantly alleviated the multi-heavy metal mixture-induced cell death and morphological changes. (spandidos-publications.com)
  • A JC-1 staining assay indicated that 20 µM luteolin inhibited the mitochondrial membrane potential-reducing effect of the multi-heavy metal mixture. (spandidos-publications.com)
  • Next we measured ROS generation ability and lipid peroxidation effect induced by luteolin and measured using TBARS assay. (alliedacademies.org)
  • Cytotoxic effects detected by lactate dehydrogenase leakage and the 3-[4,5-dimethylthiazol-2-yl]-2,5-dephenyl tetrazolium bromide-assay were restricted to higher concentrations. (aspetjournals.org)
  • The chamomile oil can be processed into pills, but the flower head can also be used as a whole to make use of the beneficial effect. (wikipedia.org)
  • Therefore, in the current study, we have used the rat model of DCM induced via a low dose of STZ and intake the high energy to the rats, to scrutinize the beneficial effect and possible mechanism of action. (alliedacademies.org)
  • New research has found IL-6 to be an anti-inflammatory cytokine with multiple beneficial effects when released by contracting muscle as a myokine. (wikipedia.org)
  • Anti-IL-6 therapies should therefore take into consideration the (beneficial) anti-inflammatory effects of myokines generally, including the now-established multiple benefits of muscle-derived Interleukin 6. (wikipedia.org)
  • In the present work, Nordeen showed that luteolin blocked this increase a beneficial effect. (bio-medicine.org)
  • Scientific studies suggest that this cactus can have beneficial effects on the liver diseases . (botanical-online.com)
  • Protective effects of luteolin against apoptotic liver damage induced by D-galactosamine/lipopolysaccharide in mice. (sparrho.com)
  • In this study, the protective effects of luteolin (1, a major component of Cirsium japonicum) were examined against d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure. (sparrho.com)
  • Protective effects of Mg-CUD against D-galactosamine-induced hepatotoxicity in rats. (sparrho.com)
  • Luteolin (LUT), a kind of flavonoid which is extracted from a variety of diets, has been reported to convey protective effects of various diseases. (sigmaaldrich.com)
  • Recent researches have suggested that LUT can carry out cardioprotective effects during ischemia/reperfusion (I/R). However, there have no reports on whether LUT can exert protective effects against myocardial I/R injury through the actions of specific microRNAs (miRs). (sigmaaldrich.com)
  • A new formulation called "BrainGain" promises to amplify luteolin's protective effects. (drhoffman.com)
  • While pretreatment of neurons with luteolin showed no benefit, exposure of microglia to this compound prevented neuron death. (lifeextension.com)
  • This demonstrated that luteolin isn't protecting the neurons directly," Dr Johnson stated. (lifeextension.com)
  • The neurons survived because the luteolin inhibited the production of neurotoxic inflammatory mediators. (lifeextension.com)
  • Luteolin reduces IL-6 production in some neurons. (wikipedia.org)
  • These diseases involve various characteristic pathological and molecular features affecting neurons in various regions of the brain. (intechopen.com)
  • This study was performed to investigate the anti-angiogenic effect of luteolin against reactive oxygen species (ROS)-induced retinal neovascularization. (arvojournals.org)
  • In this study, we showed that luteolin, a naturally occurring flavonoid, is a potent stimulator of HER2 degradation. (aacrjournals.org)
  • Our results suggest that nanoparticle delivery of naturally occurring dietary agents like luteolin has many advantages," says senior study author Dong Moon Shin, MD, professor of hematology and medical oncology at Emory University School of Medicine and associate director of academic development at Winship Cancer Institute. (redorbit.com)
  • Luteolin was purchased from the Sigma Aldrich, USA and all other chemical used in the experimental study were purchased from Sigma Aldrich, USA. (alliedacademies.org)
  • One Japanese study showed that luteolin can reduce the number and severity of the Japanese encephalitis virus. (naturalpedia.com)
  • The objective of the project will be study the effect of low power microwaves on the malaria parasite Plasmodium falciparum. (malariaworld.org)
  • In a new study published in the journal Springer Plus , University of Missouri researchers found that luteolin can decrease breast cancer risk in women taking hormone replacement therapy. (doctorshealthpress.com)
  • In the study, rats that the investigators continuously treated with luteolin had reduced brain cell damage and improved learning and memory. (medicalnewstoday.com)
  • A Randomized, Double Blind, Placebo Controlled, Parallel-Group Study to evaluate the effect of Terminalia chebula, Terminalia bellerica and Febuxostat in patients with hyperuricemia. (bodybuilding.com)
  • The purpose of this study is to examine the physiological and performance effects of T+ on power athletes. (clinicaltrials.gov)
  • Luteolin, a plant derived flavonoid, exerts a variety of pharmacological activities and anti-oxidant properties associated with its capacity to scavenge oxygen and nitrogen species. (semanticscholar.org)
  • The molecular docking results revealed luteolin actually interacted with the primary amino acid residues located within the active site pocket of XO. (nih.gov)
  • Basic research results indicate luteolin as an anti-inflammatory agent with other potential effects on septic shock. (longevityunlocked.com)
  • The results showed that luteolin and phospholipid in the complex were joined by non-covalent-bonds and did not form a new compound. (semanticscholar.org)
  • The results show that the A-ring of luteolin, in contrast to what was previously suggested, is buried within the TBS, consequently explaining the lack of activity from cynaroside. (sigmaaldrich.com)
  • Results of the investigation showed a reduction in fasting blood glucose level, Total Cholesterol (TC) and Triglyceride (TG) in luteolin-treated DCM rats. (alliedacademies.org)
  • Finally Quantitative real time PCR analysis results showed that luteolin significantly up-regulated the expression of both intrinsic and extrinsic caspases as well as executioner caspases. (alliedacademies.org)
  • Interestingly, although the fiber content is similar, the results showed that only the cactus had hypoglycemic effect. (botanical-online.com)
  • Suppressive effects of hot water extract of safflower leaves (Ex) and its major component luteolin-7-O-glucoside (LuGlc) on oxidative stress were determined in rats in which oxidative stress had been induced by paraquat (PQ). (nii.ac.jp)
  • Luteolin is a natural anti-oxidant with not as much pro-oxidant (inducing oxidative stress ) potential than the most studied flavonoid quercetin, but apparently with a better safety profile. (longevityunlocked.com)
  • Prevention of selenite induced oxidative stress and cataractogenesis by luteolin isolated from Vitex negundo. (nih.gov)
  • Concurrently, luteolin possesses potent estrogen agonist activity while quercetin is considerably less effective. (springer.com)
  • There is some evidence that alfalfa may act like estrogen, and this might affect the pregnancy. (webmd.com)
  • Alfalfa might have the same effects as the female hormone estrogen. (webmd.com)
  • The active ingredients claimed to lower plasma estrogen concentrations are red clover, luteolin, resveratrol and nettle root. (clinicaltrials.gov)
  • Keeps you energetic throughout and reduces the effects of fatigue. (nfsmi.org)
  • Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. (semanticscholar.org)
  • As of yet, however, there is no direct evidence of antitumor effects by agents that block the effect of tobacco compound nicotine (Nie) on relevant nicotinic receptors (nAChR) involved in breast tumorigenesis. (elsevier.com)
  • Recently, the antitumor effects of luteolin have been extensively investigated in breast and gastric cancer ( 6 ), melanoma ( 7 ), esophageal carcinoma ( 8 ), glioblastoma ( 9 ), hepatocellular carcinoma ( 10 ), placental choriocarcinoma ( 11 ) and lung adenocarcinoma ( 12 ). (spandidos-publications.com)
  • Does the Japanese Honeysuckle have any pharmacological effects? (gmu.edu)
  • There are numerous pharmacological effects of Japanese Honeysuckle. (gmu.edu)
  • 4 Preclinical studies have shown that the pharmacological effects of luteolin might include anti-oxidant, anti-inflammatory, antibacterial and anti-cancer. (chemicalbook.com)
  • Luteolin influenced migration by modulating the activity of Rho GTPases, signal transducers involved in transendothelial migration. (rupress.org)
  • The cardiovascular disease, particularly, the heart failure has been identified as the main cause of morbidity and mortality of patient affected by diabetes. (alliedacademies.org)
  • In particular, the effects of plants belonging to the genus Salvia and their constituents on cognitive skills including memory, attention and learning are detailed. (springer.com)
  • Luteolin has been identified from various Chinese plants such as Lonicera japonica, Elsholtzia rugulosa, Brassica oleracea and Chrysanthemum morifolium [ 8 ]. (alliedacademies.org)