A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.

Modulation of distal colonic epithelial barrier function by dietary fibre in normal rats. (1/4006)

BACKGROUND: Dietary fibre influences the turnover and differentiation of the colonic epithelium, but its effects on barrier function are unknown. AIMS: To determine whether altering the type and amount of fibre in the diet affects paracellular permeability of intestinal epithelium, and to identify the mechanisms of action. METHODS: Rats were fed isoenergetic low fibre diets with or without supplements of wheat bran (10%) or methylcellulose (10%), for four weeks. Paracellular permeability was determined by measurement of conductance and 51Cr-EDTA flux across tissue mounted in Ussing chambers. Faecal short chain fatty acid (SCFA) concentrations were assessed by gas chromatography, epithelial kinetics stathmokinetically, and mucosal brush border hydrolase activities spectrophotometrically. RESULTS: Body weight was similar across the dietary groups. Conductance and 51Cr-EDTA flux were approximately 25% higher in animals fed no fibre, compared with those fed wheat bran or methylcellulose in the distal colon, but not in the caecum or jejunum. Histologically, there was no evidence of epithelial injury or erosion associated with any diet. The fibres exerted different spectra of effects on luminal SCFA concentrations and pH, and on mucosal indexes, but both bulked the faeces, were trophic to the epithelium, and stimulated expression of a marker of epithelial differentiation. CONCLUSIONS: Both a fermentable and a non-fermentable fibre reduce paracellular permeability specifically in the distal colon, possibly by promoting epithelial cell differentiation. The mechanisms by which the two fibres exert their effects are likely to be different.  (+info)

Intracellular EDTA mimics parvalbumin in the promotion of skeletal muscle relaxation. (2/4006)

Parvalbumin (PA) is an intracellular Ca2+-binding protein found in some muscle and nerves. Its ability to bind Ca2+ and facilitate skeletal muscle relaxation is limited by its Mg2+ off-rate. EDTA serves as an "artificial" PA in that it exhibited similar rate constants for Mg2+ (3 s-1) and Ca2+ (0.7 s-1) dissociation at 10 degrees C. When introduced into frog skeletal muscle, EDTA increased the relaxation rate by approximately 2.7-fold, and with increasing tetanus duration, EDTA lost its ability to contribute to relaxation (and Ca2+ sequestration) at its Mg2+ off-rate. Intracellular EDTA recovered its ability to contribute to muscle relaxation and Ca2+ sequestration at its Ca2+ off-rate. Like PA, EDTA's contribution to muscle relaxation and Ca2+ sequestration was more clearly observed when the SR Ca-ATPase was inhibited. Introduction of EDTA into rat soleus muscle, which has low [PA], increased the relaxation rate in a manner that was analogous to the way in which PA facilitates relaxation of frog skeletal muscle. Thus intracellular EDTA serves as an effective mimic of PA, and its use should aid in our understanding of PA's function in muscle and nerve.  (+info)

Engineering a chimeric pyrroloquinoline quinone glucose dehydrogenase: improvement of EDTA tolerance, thermal stability and substrate specificity. (3/4006)

An engineered Escherichia coli PQQ glucose dehydrogenase (PQQGDH) with improved enzymatic characteristics was constructed by substituting and combining the gene-encoding protein regions responsible for EDTA tolerance, thermal stability and substrate specificity. The protein region responsible for complete EDTA tolerance in Acinetobacter calcoaceticus, which is recognized as the indicator of high stability in co-factor binding, was elucidated. The region is located between 32 and 59% from the N-terminus of A. calcoaceticus PQQGDH(A27 region) and also corresponds to the same position from 32 to 59% from the N-terminus in E. coli PQQGDH, though E. coli PQQGDH is EDTA sensitive. We previously reported that the C-terminal 3% region of A. calcoaceticus (A3 region) played an important role in the increase of thermal stability, and that His775Asn substitution in E. coli PQQGDH resulted in an increase in the substrate specificity of E. coli PQQGDH towards glucose. Based on these findings, chimeric and/or mutated PQQGDHs, E97A3 H775N, E32A27E41 H782N, E32A27E38A3 and E32A27E38A3 H782N were constructed to investigate the compatibility of two protein regions and one amino acid substitution. His775 substitution to Asn corresponded to His782 substitution to Asn (H782N) in chimeric enzymes harbouring the A27 region. Since all the chimeric PQQGDHs harbouring the A27 region were EDTA tolerant, the A27 region was found to be compatible with the other region and substituted amino acid responsible for the improvement of enzymatic properties. The contribution of the A3 region to thermal stability complemented the decrease in the thermal stability due to the His775 or His782 substitution to Asn. E32A27E38A3 H782N, which harbours all the above mentioned three regions, showed improved EDTA tolerance, thermal stability and substrate specificity. These results suggested a strategy for the construction of a semi-artificial enzyme by substituting and combining the gene-encoding protein regions responsible for the improvement of enzyme characteristics. The characteristics of constructed chimeric PQQGDH are discussed based on the predicted model, beta-propeller structure.  (+info)

Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG). (4/4006)

Tumour-selective acidification is of potential interest for enhanced therapeutic gain of pH sensitive drugs. In this study, we investigated the feasibility of a tumour-selective reduction of the extracellular and intracellular pH and their effect on the tumour response of selected anti-cancer drugs. In an in vitro L1210 leukaemic cell model, we confirmed enhanced cytotoxicity of chlorambucil at low extracellular pH conditions. In contrast, the alkylating drugs melphalan and cisplatin, and bioreductive agents mitomycin C and its derivative EO9, required low intracellular pH conditions for enhanced activation. Furthermore, a strong and pH-independent synergism was observed between the pH-equilibrating drug nigericin and melphalan, of which the mechanism is unclear. In radiation-induced fibrosarcoma (RIF-1) tumour-bearing mice, the extracellular pH was reduced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) or its analogue benzylguanidine (BG) plus glucose. To simultaneously reduce the intracellular pH, MIBG plus glucose were combined with the ionophore nigericin or the Na+/H+ exchanger inhibitor amiloride and the Na+-dependent HCO3-/Cl- exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulphonic acid (DIDS). Biochemical studies confirmed an effective reduction of the extracellular pH to approximately 6.2, and anti-tumour responses to the interventions indicated a simultaneous reduction of the intracellular pH below 6.6 for at least 3 h. Combined reduction of extra- and intracellular tumour pH with melphalan increased the tumour regrowth time to 200% of the pretreatment volume from 5.7 +/- 0.6 days for melphalan alone to 8.1 +/- 0.7 days with pH manipulation (P < 0.05). Mitomycin C related tumour growth delay was enhanced by the combined interventions from 3.8 +/- 0.5 to 5.2 +/- 0.5 days (P < 0.05), but only in tumours of relatively large sizes. The interventions were non-toxic alone or in combination with the anti-cancer drugs and did not affect melphalan biodistribution. In conclusion, we have developed non-toxic interventions for sustained and selective reduction of extra- and intracellular tumour pH which potentiated the tumour responses to selected anti-cancer drugs.  (+info)

Effects of an angiotensin-converting enzyme inhibitor and a beta-blocker on cerebral arterioles in rats. (5/4006)

We examined the effects of an angiotensin-converting enzyme inhibitor, perindopril, and a beta-blocker, propranolol, on cerebral arterioles in stroke-prone spontaneously hypertensive rats (SHRSP). The structure and mechanics of cerebral arterioles were examined in untreated Wistar-Kyoto rats (WKY) and SHRSP that were untreated or treated for 3 months with a high (2 mg/kg per day) or a low (0.3 mg/kg per day) dose of perindopril or propranolol (250 mg/kg per day) alone or in combination with the low dose of perindopril. We measured pressure, external diameter, and cross-sectional area of the vessel wall (CSA) in maximally dilated (with EDTA) cerebral arterioles. Treatment of SHRSP with the high dose of perindopril or the combination of propranolol and the low dose of perindopril normalized cerebral arteriolar mean pressure (50+/-1 [mean+/-SEM] and 43+/-2 mm Hg vs 50+/-1 mm Hg in WKY and 94+/-3 mm Hg in untreated SHRSP; P<0.05), pulse pressure (15+/-1 and 16+/-1 mm Hg vs 13+/-1 mm Hg in WKY and 35+/-1 mm Hg in untreated SHRSP; P<0.05), and CSA (1103+/-53 and 1099+/-51 microm2, respectively, vs 1057+/-49 microm2 in WKY and 1281+/-62 microm2 in untreated SHRSP; P<0.05). In contrast, treatment of SHRSP with the low dose of perindopril or propranolol alone did not normalize arteriolar pulse pressure (24+/-1 and 21+/-1 mm Hg) and failed to prevent increases in CSA (1282+/-77 and 1267+/-94 microm2). Treatment with either dose of perindopril or the combination of propranolol and perindopril significantly increased external diameter in cerebral arterioles of SHRSP (99+/-3, 103+/-2, and 98+/-3 microm vs 87+/-2 microm in untreated SHRSP; P<0.05), whereas propranolol alone did not (94+/-3 microm; P>0.05). These findings suggest that effects of angiotensin-converting enzyme inhibitors on cerebral arteriolar hypertrophy in SHRSP may depend primarily on their effects on arterial pressure, particularly pulse pressure, whereas their effects on cerebral arteriolar remodeling (defined as a reduction in external diameter) may be pressure independent.  (+info)

Pretargeting of bacterial endocarditis in rats with streptavidin and 111In-labeled biotin. (6/4006)

A radioimaging approach for the detection of endocarditis has been investigated using two-step pretargeting with streptavidin and radiolabeled biotin. METHODS: Hemodynamic alterations within the rat heart were induced by placing an in-dwelling catheter into the left ventricle through the aortic valves. The animals were subsequently infected with Staphylococcus aureus through a tail vein. After an incubation period, rats were first injected with streptavidin and, 2 h later, with 111In-labeled ethylene-diaminetetraacetic acid-biotin. Whole-body gamma camera images were taken 4-5 h postinjection of the radiolabeled biotin. Control animals consisted of catheterized but uninfected, infected but uncatheterized and normal untreated rats. As a further control, the labeled biotin was administered to a study animal without the preadministration of streptavidin. RESULTS: Histology showed typical endocarditic changes in the hearts of study animals with massive deposition of gram-positive cocci. Catheterized but uninfected animals showed alterations corresponding to nonbacterial thrombotic endocarditis. Macroautoradiography showed accumulation of radiolabel in the endocarditic vegetations of study animals. Whole-body gamma camera images showed important cardiac uptake in 7 of 8 catheterized and infected animals and in 3 of 6 catheterized but uninfected animals. Normal rats and those infected but not catheterized showed negative results by histology, autoradiography and imaging. The percent uptake of the injected dose in the heart was 0.20 (SD = 0.13) in catheterized and infected animals, 0.12 (SD = 0.10) in catheterized but uninfected animals, 0.10 (SD = 0.04) in infected but uncatheterized animals and 0.04 (SD = 0.01) in normal control animals. CONCLUSION: The two-step pretargeting approach using streptavidin and 111In-labeled biotin was used successfully to detect S. aureus-induced bacterial endocarditis in rats.  (+info)

Metalloproteinases are involved in lipopolysaccharide- and tumor necrosis factor-alpha-mediated regulation of CXCR1 and CXCR2 chemokine receptor expression. (7/4006)

The neutrophil-specific G-protein-coupled chemokine receptors, CXCR1 and CXCR2, bind with high affinity to the potent chemoattractant interleukin-8 (IL-8). The mechanisms of IL-8 receptor regulation are not well defined, although previous studies have suggested a process of ligand-promoted internalization as a putative regulatory pathway. Herein, we provide evidence for two distinct processes of CXCR1 and CXCR2 regulation. Confocal microscopy data showed a redistribution of CXCR1 expression from the cell surface of neutrophils to internal compartments after stimulation with IL-8, whereas stimulation with bacterial lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-alpha) did not induce CXCR1 internalization but instead mediated a significant loss of membrane-proximal CXCR1 staining intensity. To investigate whether proteolytic cleavage was the mechanism responsible for LPS- and TNF-alpha-induced downmodulation of IL-8 receptors, we tested a panel of proteinase inhibitors. The downmodulation of CXCR1 and CXCR2 by LPS and TNF-alpha was most dramatically inhibited by metalloproteinase inhibitors; 1, 10-phenanthroline and EDTA significantly attenuated LPS- and TNF-alpha-induced loss of CXCR1 and CXCR2 cell surface expression. Metalloproteinase inhibitors also blocked the release of CXCR1 cleavage fragments into the cell supernatants of LPS- and TNF-alpha-stimulated neutrophils. In addition, while treatment of neutrophils with LPS and TNF-alpha inhibited IL-8 receptor-mediated calcium mobilization and IL-8-directed neutrophil chemotaxis, both 1, 10-phenanthroline and EDTA blocked these inhibitory processes. In contrast, metalloproteinase inhibitors did not affect IL-8-mediated downmodulation of CXCR1 and CXCR2 cell surface expression or receptor signaling. Thus, these findings may provide further insight into the mechanisms of leukocyte regulation during immunologic and inflammatory responses.  (+info)

Nucleoside diphosphate kinase activity in soluble transducin preparations biochemical properties and possible role of transducin-beta as phosphorylated enzyme intermediate. (8/4006)

Known nucleoside diphosphate kinases (NDPKs) are oligomers of 17-23-kDa subunits and catalyze the reaction N1TP + N2DP --> N1DP + N2TP via formation of a histidine-phosphorylated enzyme intermediate. NDPKs are involved in the activation of heterotrimeric GTP-binding proteins (G-proteins) by catalyzing the formation of GTP from GDP, but the properties of G-protein-associated NDPKs are still incompletely known. The aim of our present study was to characterize NDPK in soluble preparations of the retinal G-protein transducin. The NDPK is operationally referred to as transducin-NDPK. Like known NDPKs, transducin-NDPK utilizes NTPs and phosphorothioate analogs of NTPs as substrates. GDP was a more effective phosphoryl group acceptor at transducin-NDPK than ADP and CDP, and guanosine 5'-[gamma-thio]triphosphate (GTP[S]) was a more effective thiophosphoryl group donor than adenosine 5'-[gamma-thio]triphosphate (ATP[S]). In contrast with their action on known NDPKs, mastoparan and mastoparan 7 had no stimulatory effect on transducin-NDPK. Guanosine 5'-[beta, gamma-imido]triphosphate (p[NH]ppG) potentiated [3H]GTP[S] formation from [3H]GDP and ATP[S] but not [3H]GTP[S] formation from [3H]GDP and GTP[S]. Depending on the thiophosphoryl group acceptor and donor, [3H]NTP[S] formation was differentially regulated by Mg2+, Mn2+, Co2+, Ca2+ and Zn2+. [gamma-32P]ATP and [gamma-32P]GTP [32P]phosphorylated, and [35S]ATP[S] [35S]thiophosphorylated, a 36-kDa protein comigrating with transducin-beta. p[NH]ppG potentiated [35S]thiophosphorylation of the 36-kDa protein. 32P-labeling of the 36-kDa protein showed characteristics of histidine phosphorylation. There was no evidence for (thio)phosphorylation of 17-23-kDa proteins. Our data show the following: (a) soluble transducin preparations contain a GDP-prefering and guanine nucleotide-regulated NDPK; (b) transducin-beta may serve as a (thio)phosphorylated NDPK intermediate; (c) transducin-NDPK is distinct from known NDPKs and may consist of multiple kinases or a single kinase with multiple regulatory domains.  (+info)

Edetic acid, also known as ethylenediaminetetraacetic acid (EDTA), is not a medical term per se, but a chemical compound with various applications in medicine. EDTA is a synthetic amino acid that acts as a chelating agent, which means it can bind to metallic ions and form stable complexes.

In medicine, EDTA is primarily used in the treatment of heavy metal poisoning, such as lead or mercury toxicity. It works by binding to the toxic metal ions in the body, forming a stable compound that can be excreted through urine. This helps reduce the levels of harmful metals in the body and alleviate their toxic effects.

EDTA is also used in some diagnostic tests, such as the determination of calcium levels in blood. Additionally, it has been explored as a potential therapy for conditions like atherosclerosis and Alzheimer's disease, although its efficacy in these areas remains controversial and unproven.

It is important to note that EDTA should only be administered under medical supervision due to its potential side effects and the need for careful monitoring of its use.

It is a salt of edetic acid. It has been known at least since 1954. It is sometimes used as a chelating agent. The assignee on ... "Ethylenediaminetetraacetic Acid and Related Chelating Agents". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ... T. T. Trujillo, H. Foreman (1954). "The metabolism of C14 labeled ethylenediaminetetraacetic acid in human beings". The Journal ... Tetrasodium EDTA is the salt resulting from the neutralization of ethylenediaminetetraacetic acid with four equivalents of ...
... (EDTA), also called edetic acid after its own abbreviation, is an aminopolycarboxylic acid with ... polyaspartic acid, S,S-ethylenediamine-N,N′-disuccinic acid (EDDS), methylglycinediacetic acid (MGDA), and L-Glutamic acid N,N- ... Candidate chelating agents include nitrilotriacetic acid (NTA), iminodisuccinic acid (IDS), ... diacetic acid, tetrasodium salt (GLDA). Commercially used since 1998, iminodisuccinic acid (IDS) biodegrades by about 80% after ...
4-Dioxane 50 μg/L Edetic acid 600 μg/L Ethylbenzene 300 μg/L Hexachlorobutadiene 0.6 μg/L Nitrilotriacetic acid 200 μg/L ...
... edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - iodoacetic acid MeSH D02.241.081.038.581.400 - ... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... edetic acid MeSH D02.092.782.258.368.257 - egtazic acid MeSH D02.092.782.258.368.265 - ethambutol MeSH D02.092.782.258.368.500 ... hexuronic acids MeSH D02.241.081.844.915.400.500 - iduronic acid MeSH D02.241.081.901.177 - aconitic acid MeSH D02.241.081.901. ...
... edetic acid (INN) edetol (INN) Edex. Redirects to Prostaglandin E1. edifoligide (USAN) edifolone (INN) edobacomab (INN) ... egtazic acid (INN) egualen (INN) elacridar (INN) elacytarabine (USAN, INN) elagolix (USAN, INN) elantrine (INN) elanzepine (INN ... redirects to rasburicase Elixicon Elixomin Elixophyllin ellagic acid (INN) Ellence Ellence (Pharmacia & Upjohn Company) ...
Edetic Acid (EDTA) Summary Description: A chelating agent (CHELATING AGENTS) that sequesters a variety of polyvalent cations. ... Key Diseases for which Edetic Acid is Relevant. * Smear Layer : 56 outcomes 81 studies in 288 results ...
Explore the 404 possible drugs interactions for Edetic Acid and the research papers that mention these interactions. ... Edetic Acid. A.K.A: EDTA, Ethylenediaminetetraacetic acid, ethylenediaminetetraacetic acid (EDTA), …(more) ...
European Risk Assessment Report CAS 60-00-4 EC 200-449-4 edetic acid (EDTA). Author:. European Chemical Bureau Institute of ...
Explore the 1 paper that mention a possible interaction between Edetic Acid and Transfer Factor. ...
Edetic Acid* * Female * Glomerular Filtration Rate / physiology* * Humans * Lung Transplantation / adverse effects* ... The glomerular filtration rate (GFR) was measured using the (51)Cr-ethylenediaminetetra acetic acid plasma clearance single ...
Edetic Acid / pharmacology * Electrophysiology * In Vitro Techniques * Lung / physiology* * Oxygen Consumption / drug effects ...
It is a salt of edetic acid. It has been known at least since 1954. It is sometimes used as a chelating agent. The assignee on ... "Ethylenediaminetetraacetic Acid and Related Chelating Agents". Ullmanns Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ... T. T. Trujillo, H. Foreman (1954). "The metabolism of C14 labeled ethylenediaminetetraacetic acid in human beings". The Journal ... Tetrasodium EDTA is the salt resulting from the neutralization of ethylenediaminetetraacetic acid with four equivalents of ...
Alkalies, Chelating Agents, Chlorides/analysis, Edetic Acid, Egypt, Hydrogen-Ion Concentration, Iron/analysis, Lead/analysis, ... Acetic acid accelerated the formation of both BADGE.2H2O and BADGE.HCl.H2O in NaCl. No BPA was detected in any simulation ... and 0.01 N NaCl with acetic acid (pH 2.5), respectively, when it was allowed to stand at 120 degrees C for 30 min. The ...
Read across to structural analogue Edetic acid. For justification of read across see IUCLID section 13. The dissociation ...
Edetic Acid (EDTA) ... Acetylsalicylic Acid), Caffeine (No Doz) * Tambocor - tablet, ...
Lidoquest Acid, also known as Ethylenediaminetetraacetic Acid (EDTA) and Edetic Acid, is a metal complexing agent. The ... RE: The tariff classification of Lidoquest Acid (CAS # 60-00-4), Lidoquest NA2-P (CAS # 139-33-3) and Lidoquest NA4-P (CAS # 64 ... Tariff No.: 2922.49.80 - Non-aromatic esters of amino-acids, other than those containing more than one kind of oxygen function ... Tariff No.: 2922.49.40 - Nonaromatic amino-acids, other than those containing more than one kind of oxygen function, nesoi ...
Browse a full range of Organic acids and derivatives products from leading suppliers. Shop now at Fisher Scientific for all of ... edta,edetic acid,ethylenediaminetetraacetic acid,edathamil,versene,endrate,havidote,titriplex,edta acid,sequestrol. ... isovaleric acid,isopentanoic acid,3-methylbutyric acid,delphinic acid,isopropylacetic acid,butanoic acid, 3-methyl, ... propionic acid,ethylformic acid,methylacetic acid,carboxyethane,ethanecarboxylic acid,pseudoacetic acid,metacetonic acid, ...
Apparent failure of edetic acid chelation therapy for the treatment of coronary atherosclerosis. DICP. 1990;24(1):22-25. ... Dimercaptosuccinic acid (DMSA) or ethylenediaminetetraacetic (EDTA) provocative chelation/mobilization test:. NO specific code ... Succimer (meso-2, 3-dimercaptosuccinic acid) was given at a daily dose of 30 mg/kg for 5 days in a double-blind, randomized ... Glotzer (1993) stated that 2,3-dimercaptosuccinic acid (DMSA) is an orally active chelating agent used in the treatment of lead ...
... and elevation of urinary delta aminolevulinic acid (ALA) (adults: , 4 mg/day; pediatric patients: , 3 mg/m2/day) are associated ...
Some compounds of hexavalent chromium are well-established carcinogens. Chromium enters mammalian cells in the hexavalent form and is reduced to chromium (III). Treatment of purified DNA with chromium (III) produces DNA-DNA interstrand crosslinks (DDC) which obstruct the progression of DNA polymerases in vitro. DDC were also detected in chromate-treated cultured normal human lung cells using the renaturing agarose gel electrophoresis (RAGE) assay and correlated with base-specific inhibition of DNA replication. Curiously, DDC have gone undetected in studies of cultured cells using the alkaline elution (AE) technique, whereas chromium-mediated DNA-protein crosslinks (DPC) were readily detected by AE. We tested the hypothesis that AE conditions [60 mM tetraethyl ammonium hydroxide (TEA), 20 mM EDTA, pH 12.6, for 16 h at room temperature] dissociate DDC but not DPC using chromium(III)-treated plasmid DNA and the RAGE assay. Dose-dependent chromium-induced DDC were unaffected by TEA (pH 11.8) alone ...
Ethylenediaminetetraacetic acid (edetic acid). EEG:. Electroencephalography. EMQ:. Everyday Memory Questionary. EPI:. Echo ... We will collect blood in serum tubes, whole blood in EDTA tubes (Ethylenediaminetetraacetic acid), and PAX-gen tubes (for ... we aim to supplement the measurements of peripheral biomarker levels by peripheral blood messenger ribonucleic acid (mRNA) ...
A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.. Terms. Egtazic Acid Preferred Term ... A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.. Entry Term(s). EGATA EGTA Egtazic Acid ... Egtazic Acid Potassium Salt Egtazic Acid Sodium Salt Ethylene Glycol Bis(2-aminoethyl ether)tetraacetic Acid Ethylene Glycol ... Egtazic Acid Disodium Salt Narrower Concept UI. M0330429. Registry Number. 0. Terms. Egtazic Acid Disodium Salt Preferred Term ...
All tissue specimens had been fixed in 5% buffered formalin, embedded in paraffin wax, and mildly decalcified in edetic acid ... 7 Detection of the c-kit point mutation was performed using peptide nucleic acid mediated PCR clamping and Light Cycler ...
Edetic Acid, Fruit, Vegetables, Pantothenic Acid, Confidence Intervals, Surveys and Questionnaires, Thiamine, Mental Health, ... Chelation therapy with disodium ethylene diamine tetra acetic acid (EDTA) is sometimes suggested as an alternative medicine ... pantothenic acid, thiamine, pyridoxine, procaine (100 mg), unfractionated heparin, 2500 U, and sterile water to 500 ml. Placebo ... ascorbic acid (7 grams), magnesium chloride (2 grams), potassium chloride (2 mEq), sodium bicarbonate (840 mg), ...
edetic acid. *keratinase. *lysine decarboxylase. *ornithine decarboxylase. *oxidoreductase. *polysorbate 80. *triacylglycerol ...
Ethylenediaminetetraacetic Acid -- See Edetic Acid A chelating agent that sequesters a variety of polyvalent cations such as ... Ethylenediaminetetraacetic acid. 2 Ethylenediaminetetraacetic acid -- Environmental aspects : EDTA : synthesis, uses, and ... Ethylenediaminetetraacetic acid -- Research : Its all in the water : studies of materials and conditions in fresh and salt ...
Also called edetic acid and etheylenediaminetetraacetic acid. Ethylenediaminetetraacetic acid (EDTA), also known by several ...
Maghsoudlou, P., Georgiades, F., Tyraskis, A., Totonelli, G., Loukogeorgakis, S. P., Orlando, G., Shangaris, P., Lange, P., Delalande, J. M., Burns, A. J., Cenedese, A., Sebire, N. J., Turmaine, M., Guest, B. N., Alcorn, J. F., Atala, A., Birchall, M. A., Elliott, M. J., Eaton, S., Pierro, A., & 2 othersGilbert, T. W. & De Coppi, P., 1 Sept 2013, In: Biomaterials. 34, 28, p. 6638-6648 11 p.. Research output: Contribution to journal › Article › peer-review ...
Matched Synonyms: … Edetic acid calcium disodium salt … Gabapentin. Gabapentin is a structural analogue of the inhibitory ... Matched Mixtures name: … Mi Acid ... ConRx Acid Reducer ... Acid Reducer Complete … Matched Categories: … Carbonic Acid ... ... Drugs for Acid Related Disorders ... ascorbic acid (vit C) and calcium … Matched Products: … ACID STOP ... Medique Ban-acid ... Matched Synonyms: … Disodium acid phosphate ... Phosphoric acid, sodium salt (1:2) ... Phosphoric acid, disodium salt, ...
Edetic Acid; Moringa Oleifera Seed Extract; Phenoxyethanol; Hexyl Cinnamal; Dextrolimonene; Carbocisteine; Hydrolyzed Wheat ... Citric acid; Propylene glycol; Sodium Pidolate; Methicone; Polyethylene Glycol-12 Tridecyl Alcohol Ether; Hydrolyzed Wheat ...
Palavras-chave : Calcium hydroxide.; Dental pulp cavity.; Edetic acid.; Smear Layer.. · resumo em Português · texto em Inglês ...
Edetic Acid. PubChem Compound ID:. 156397. Description:. A chelating agent (CHELATING AGENTS) that sequesters a variety of ...
  • Tetrasodium EDTA is the salt resulting from the neutralization of ethylenediaminetetraacetic acid with four equivalents of sodium hydroxide (or an equivalent sodium base). (wikipedia.org)
  • Ethylenediaminetetraacetic acid is produced commercially via the intermediacy of tetrasodium EDTA. (wikipedia.org)
  • Lidoquest Acid, also known as Ethylenediaminetetraacetic Acid (EDTA) and Edetic Acid, is a metal complexing agent. (faqs.org)
  • Ethylenediaminetetraacetic acid (EDTA), also known by several other names, is a chemical used for both industrial and medical purposes EDTA solution will be standardize by titration against a standard solution made from calcium carbonate, CaCO3. (microsidd.com)
  • Stiffness and adhesion force were determined before and after application of 5.25% sodium hypochlorite (NaOCl) and 17% ethylenediaminetetraacetic acid (EDTA). (elsevierpure.com)
  • Aetna considers the dimercaptosuccinic acid (DMSA) or ethylenediaminetetraacetic (EDTA) provocative chelation/mobilization test experimental and investigational as a means of diagnosing lead toxicity because of insufficient evidence of its effectiveness. (aetna.com)
  • Chelation therapy with disodium ethylene diamine tetra acetic acid (EDTA) is sometimes suggested as an alternative medicine approach to the treatment of coronary artery disease (CAD). (acc.org)
  • A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID . (nih.gov)
  • Read across to structural analogue Edetic acid. (europa.eu)
  • Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) that was first approved for use in the United States in 1993. (drugbank.com)
  • The glomerular filtration rate (GFR) was measured using the (51)Cr-ethylenediaminetetra acetic acid plasma clearance single injection technique (mGFR) at baseline before transplantation and at 1, 2, 3 and 12 weeks postoperatively. (nih.gov)
  • Chelating agents such as Dimercaprol, Penicillamine or Edetic Acid have been recommended. (com.bd)
  • The amount-of-substance concentration of this volumetric solution is traceable to a primary standard reference material (SRM) from the National Institute of Standards and Technology, Gaithersburg, USA (NIST SRM 682 Zinc) by means of volumetric standard Zinc (article number 1.02409), certified reference material according to ISO 17034, analyzed by our accredited calibration laboratory of Merck KGaA, Darmstadt, Germany according to DIN EN ISO/IEC 17025. (fgskimya.com)
  • This is indicated for the treatment and prophylaxis of Iron, Folic Acid and Zinc deficiency especially during pregnancy and lactation. (com.bd)
  • Thus administration of Iron during the first trimester requires definite evidence of Iron deficiency where inadequate diet calls for supplementary Zinc and Folic acid is justified during the remainder of the pregnancy. (com.bd)
  • salts thereof: other: other: amino acids: other. (faqs.org)
  • Fluciclovine is a [18F]-tagged synthetic analog of the amino acid L-leucine. (drugbank.com)
  • The structure of fluciclovine allows it to be uptaken by the tumoral cells by its amino acid transporter without incorporating in the metabolism within the. (drugbank.com)
  • Mupirocin, formerly termed pseudomonic acid A, is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. (drugbank.com)
  • Lidoquest NA-4P, also known as Tetrasodium ethylenediaminetetraaectic Acid, is a metal complexing agent. (faqs.org)
  • The group, that used edetic acid , statistically improved the periodontal parameters in relation to the group without surface biomodification. (bvsalud.org)
  • Organic compounds with acidic properties, and will commonly have carboxylic acids or similar functional groups in their structure. (fishersci.com)
  • in four who received calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA) (1000 mg/m2 per day intravenously), it decreased by 45% (p less than 0.0007). (nih.gov)
  • Ethylene Diamine Tetra Acetic Acid works as an effective stabilizer. (vedaoils.com)
  • Ethylene diamine tetra acetic acid is preferred in hair products due to its cleansing properties, and it is also used in shampoos and conditioners as an anionic chelating component. (vedaoils.com)
  • It is a polycarboxylic amino acid that dissolves readily in water, and it is mainly obtained from sodium salts. (vedaoils.com)
  • May contain citric acid to adjust pH. (nih.gov)
  • Benzoic acid (BA) is a commonly used antimicrobial preservative in food and beverages, especially in carbonated beverages, as it presents its strongest antibacterial activity at pH 2.5 4.0. (chemicalstore.com)
  • Linear alkylbenzene sulfonic acid is mainly used to produce household detergents including laundry powders, laundry liquids, dishwashing liquids and other household cleaners as well as in numerous industrial applications like as a coupling agent and as an emulsifier for agricultural herbicides and in emulsion polymerization. (chemicalstore.com)
  • Sulfuric acid 10% solution is made by diluting strong sulfuric acid with water. (chemicalstore.com)
  • Your search for EDETIC ACID did not return any results. (nih.gov)
  • Sorbic acid is effective against many microorganisms and is commonly used in baked goods, cheese, and wine products. (chemicalstore.com)
  • Malic Acid, Food grade, for manufacturing and laboratory applications. (chemicalstore.com)
  • While high purity sulfuric acid is clear, our product is technical grade and may be cloudy and amber color. (chemicalstore.com)