An imidazole derivative that is commonly used as a topical antifungal agent.
An imidazole antifungal agent that is used topically and by intravenous infusion.
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Derivatives of orthoaminobenzoic acid that have a phenyl group bound to the orthoamino nitrogen. Members modulate ION CHANNELS and are used as ANTI-INFLAMMATORY AGENTS.
Infection of the VULVA and VAGINA with a fungus of the genus CANDIDA.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
A country spanning from central Asia to the Pacific Ocean.
Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
An enzyme that catalyzes the oxidation of nitrite to nitrate. It is a cytochrome protein that contains IRON and MOLYBDENUM.
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Materials incorporated mechanically in plastics (usually PVC) to increase flexibility, workability or distensibility; due to the non-chemical inclusion, plasticizers leach out from the plastic and are found in body fluids and the general environment.
An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
A plant genus of the family LILIACEAE. Members contain tuliposides and tulipalins and have been associated with allergic contact dermatitis in florists.
The branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.
Five membered rings containing a NITROGEN atom.
Hydrocarbons with more than one double bond. They are a reduced form of POLYYNES.
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)

Comparison of the toxicity of fluconazole and other azole antifungal drugs to murine and human granulocyte-macrophage progenitor cells in vitro. (1/56)

We studied the inhibitory effects on colony formation by granulocyte-macrophage colony forming units (cfu-gm) of eight azole antifungal agents in vitro. All agents, except fluconazole, inhibited colony formation dose-dependently with 50% inhibitory concentrations (IC50) in the range of 0.78-49 micromol/L in cultures of murine and human bone marrow. For human cells, the IC50 values were 0.553 mg/L for itraconazole, 1.24 mg/L for saperconazole, 2.58 mg/L for clotrimazole, 5.33 mg/L for miconazole, 6.17 mg/L for econazole, 6.27 mg/L for ketoconazole and 8.38 mg/L for oxiconazole. The IC50 of itraconazole for human cfu-gm in vitro was similar to the plasma level of this drug recommended for systemic antifungal therapy (>0.5 mg/L) thus indicating the potential clinical relevance of our data. The IC50 of ketoconazole for human cfu-gm in vitro may be exceeded by plasma levels produced in vivo by high (> or =400 mg) doses, whereas fluconazole failed to reduce colony formation by 50% even at 100 mg/L, a concentration not reached in vivo even after extremely high doses (2000 mg/day). To most of the drugs studied, murine progenitor cells seemed to be less sensitive than the human ones. There was, however, a close correlation between the murine and human log IC50 values of the drugs (r2 = 0.964, P< 0.001), suggesting that cultures of murine bone marrow may be suitable to predict the in-vitro toxicity of azole antifungals to human cfu-gm.  (+info)

In-vitro resistance to azoles associated with mitochondrial DNA deficiency in Candida glabrata. (2/56)

A commercially available disk diffusion procedure was used in a large-scale study to evaluate the susceptibility of a wide range of Candida isolates to polyenes and azoles. With almost all isolates of C. glabrata resistant colonies were present within the inhibition zones for the azole compounds fluconazole, ketoconazole and miconazole, and less frequently for isoconazole, econazole and clotrimazole. Ten randomly selected isolates were cloned by limiting dilution and the susceptibility of the resulting strains to polyenes and azoles was determined. All strains presented a similar susceptibility pattern with sensitivity to polyenes and the presence of resistant colonies for all azole compounds except tioconazole. For each strain and each antifungal agent, one of these resistant colonies was subcultured and studied for antifungal susceptibility. All these colonies showed similar properties regardless of which antifungal agent allowed their selection, with increased sensitivity to polyenes and cross-resistance to the azole compounds except tioconazole. Similar results were obtained on Shadomy's modified medium and on synthetic medium. Likewise, determination of MICs by the Etest method confirmed the resistance to fluconazole. Comparative growth studies revealed a respiratory deficiency in the mutants caused by mitochondrial DNA (mtDNA) deletions. In addition, 'petite' mutants were obtained from a wild-type strain by exposure to ethidium bromide, and these respiratory mutants were shown to be resistant to azoles. These results demonstrate the relationship between mtDNA deficiency and resistance to azoles, and provide an interesting model to study the mechanisms of action of these antifungal agents.  (+info)

In vitro activities of ketoconazole, econazole, miconazole, and Melaleuca alternifolia (tea tree) oil against Malassezia species. (3/56)

The in vitro activities of ketoconazole, econazole, miconazole, and tea tree oil against 54 Malassezia isolates were determined by agar and broth dilution methods. Ketoconazole was more active than both econazole and miconazole, which showed very similar activities. M. furfur was the least susceptible species. M. sympodialis, M. slooffiae, M. globosa, and M. obtusa showed similar susceptibilities to the four agents.  (+info)

Positive and negative control of multidrug resistance by the Sit4 protein phosphatase in Kluyveromyces lactis. (4/56)

The nuclear gene encoding the Sit4 protein phosphatase was identified in the budding yeast Kluyveromyces lactis. K. lactis cells carrying a disrupted sit4 allele are resistant to oligomycin, antimycin, ketoconazole, and econazole but hypersensitive to paromomycin, sorbic acid, and 4-nitroquinoline-N-oxide (4-NQO). Overexpression of SIT4 leads to an elevation in resistance to paromomycin and to lesser extent tolerance to sorbic acid, but it has no detectable effect on resistance to 4-NQO. These observations suggest that the Sit4 protein phosphatase has a broad role in modulating multidrug resistance in K. lactis. Expression or activity of a membrane transporter specific for paromomycin and the ABC pumps responsible for 4-NQO and sorbic acid would be positively regulated by Sit4p. In contrast, the function of a Pdr5-type transporter responsible for ketoconazole and econazole extrusion, and probably also for efflux of oligomycin and antimycin, is likely to be negatively regulated by the phosphatase. Drug resistance of sit4 mutants was shown to be mediated by ABC transporters as efflux of the anionic fluorescent dye rhodamine 6G, a substrate for the Pdr5-type pump, is markedly increased in sit4 mutants in an energy-dependent and FK506-sensitive manner.  (+info)

Effect of cytochrome P-450 inhibitors econazole, bifonazole and clotrimazole on prostanoid formation. (5/56)

1. The present study was carried out to clarify the effect of the imidazole antimycotics econazole, bifonazole and clotrimazole on prostanoid biosynthesis. Osteoblast-like MC3T3-E1 cells stimulated by endothelin-1, melittin, ionomycin or arachidonic acid showed diminished prostaglandin E(2) (PGE(2)) production upon pretreatment with econazole. Following pretreatment with bifonazole, stimulation with ionomycin or arachidonic acid also resulted in decreased PGE(2) formation. Clotrimazole inhibited ionomycin but not arachidonic acid stimulated PGE(2) synthesis in MC3T3-E1 cells. 2. The results observed in osteoblast-like UMR-106 cells pretreated with econazole, bifonazole or clotrimazole and stimulated by arachidonic acid were similar with the exception of clotrimazole which was a more effective inhibitor of PGE(2) biosynthesis than in MC3T3-E1 cells. 3. Upon treatment with arachidonic acid thromboxane B(2) (TXB(2)) production in human platelets was abolished completely at concentrations of the three imidazole antimycotics higher than 5 microM (IC(50)<1 microM). 4. These data were confirmed by a direct assay using purified ram seminal vesicle prostaglandin H(2) synthase-1 (PGHS-1), which clearly showed inhibitory properties of econazole (IC(50) 4.7+/-2.3 microM), bifonazole (IC(50) 9.4+/-0.8 microM) and clotrimazole (IC(50) 4.4+/-0.6 microM). 5. Summarizing, these results indicate an inhibitory effect of econazole, bifonazole and clotrimazole on PGHS-1, varying in its potency dependent on the cell system used. In addition TXB(2) formation is affected at doses even lower than those needed to suppress PGE(2) biosynthesis.  (+info)

Activity of the Kluyveromyces lactis Pdr5 multidrug transporter is modulated by the Sit4 protein phosphatase. (6/56)

A possible role for posttranslational modifications in regulating the activity of ATP-binding cassette (ABC) transporters has not been well established. In this study, the drug efflux ABC transporter gene KlPDR5 was isolated from the budding yeast Kluyveromyces lactis, and it was found that the encoded KlPdr5 drug pump is posttranslationally regulated by the type 2A-related Ser/Thr protein phosphatase, Sit4p. The KlPdr5 transporter is a protein of 1,525 amino acids sharing 63.8% sequence identity with its Saccharomyces cerevisiae counterpart, ScPdr5p. Overexpression of the KlPDR5 gene confers resistance to oligomycin, antimycin, econazole, and ketoconazole, whereas cells with a disrupted allele of KlPDR5 are hypersensitive to the drugs and have a decreased capacity to carry out efflux of the anionic fluorescent dye rhodamine 123. It was found that a chromosomal disruption of KlPDR5 abolishes the drug-resistant phenotype associated with sit4 mutations and that a synergistic hyperresistance to the drugs can be created by overexpressing KlPDR5 in sit4 mutants. These data strongly indicate that the multidrug-resistant phenotype of sit4 mutants is mediated by negatively modulating the activity of KlPdr5p. As the transcriptional level of KlPDR5 and the steady-state level of KlPdr5p are not significantly affected by mutations in SIT4, the regulation by Sit4p appears to be a posttranslational process.  (+info)

Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1. (7/56)

1. The recent identification of the epithelial Ca(2+) channel, ECaC1, represents a major step forward in our knowledge of renal Ca(2+) handling. ECaC1 constitutes the rate-limiting apical Ca(2+) entry mechanism of active, transcellular Ca(2+) reabsorption. This unique highly selective Ca(2+) channel shares a low but significant homology with transient receptor potential (TRP) channels and vanilloid receptors (VR). 2. We have studied the pharmacological modulation of currents through ECaC1 heterologously expressed in HEK 293 cells. Monovalent cation currents were measured by use of the whole cell patch clamp technique in cells dialysed with 10 mM BAPTA or 10 mM EGTA to prevent the fast Ca(2+) dependent inactivation of ECaC1. 3. Several modulators were tested, including inorganic cations, putative store-operated Ca(2+) entry (SOC) blockers, the vanilloid receptor (VR-1) blocker capsazepine, protein tyrosine kinase blockers, calmodulin antagonists and ruthenium red. 4. Ruthenium red and econazole appeared to be the most effective inhibitors of currents through ECaC1, with IC(50) values of 111 nM and 1.3 microM, respectively, whereas the selective SOC inhibitor, SKF96365, was nearly ineffective. 5. The divalent cation current block profile for ECaC1 is Pb(2+)=Cu(2+) >Zn(2+) >Co(2+) >Fe(2+) with IC(50) values between 1 and approximately 10 microM. 6. In conclusion, ECaC activity is effectively inhibited by various compounds including ruthenium red, antimycotic drugs and divalent cations, which might be useful tools for pharmacological manipulation and several disorders related to Ca(2+) homeostasis could benefit from such developments.  (+info)

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. (8/56)

Depletion of Ca(2+) from the endoplasmic reticulum (ER) induces large increases in cytoplasmic Ca(2+), mitochondrial Ca(2+) loading, protein synthesis inhibition, and cell death. To clarify the connections among these events, we have evaluated the effect of Ca(2+) mobilizing agents thapsigargin (Tg), econazole (Ec), and the growth factor Steel Factor (SLF) on bone marrow-derived mast cells (BMMCs). BMMC Ca(2+) stores were found to consist of a Tg-sensitive ER compartment, the Tg-insensitive SIC store, and mitochondrial stores. Low levels of Ec interfered with Tg-stimulated mitochondrial loading while promoting progressive leakage of Ca(2+) from the ER. Low levels of Ec completely reversed Tg toxicity while higher levels blocked store-operated influx and induced cell death in a SLF-enhanced manner. Both Ec and Tg inhibited protein synthesis, however, only SLF plus Tg or very high levels of Ec were able to significantly stimulate EIF-2alpha phosphorylation. Cycloheximide only partially protected BMMCs from Tg toxicity yet strongly synergized with Ec to induce cell death. These results therefore indicate that although both Tg and Ec deplete ER Ca(2+) levels, Ec-induced cell death results from sustained protein synthesis inhibition while Tg toxicity results primarily from mitochondrial Ca(2+) overload and secondarily from ER stress associated with Ca(2+) depletion.  (+info)

My daughter has had ringworn off and on since last March. She is now has three lesions and is being treated with econazole nitrate 1%. Prior she was using.. Serious side effects of Spectazole (econazole nitrate) Cream use are unexpected. Common side effects of Spectazole (econazole nitrate) Cream include: burning,; stinging,; swelling,; irritation,; redness,; pimple-like bumps,; tenderness, or; flaking of the treated skin. Tell your doctor if you have: unusual or severe blistering,. How to use Econazole Foam. Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using econazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Use this medication on the skin only. Clean and thoroughly dry the area to be.. Pevaryl cream contains the active ingredient econazole nitrate. Econazole is an antifungal medicine used to treat infections with fungi and yeasts.. EVERYTHING you need to know about how to treat ...
Looking for online definition of econazole in the Medical Dictionary? econazole explanation free. What is econazole? Meaning of econazole medical term. What does econazole mean?
Econazole nitrate CAS Number:68797-31-9 Name:1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate Formula:C18H15Cl3N2O.HNO3 Molecular Weight:444.70 Synonyms: Ecostatin;(+-)-Econazole;1H-Imidazole,...
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HPLC Application #17394: Econazole on Lux Cellulose-1. Column used: Lux® 5 µm Cellulose-1, LC Column 250 x 4.6 mm, Ea Part#: 00G-4459-E0
COMPOSITION : Econazolum nitricum 1% Triarnoinolon-acetonidum 0.1% Conserv. (Acid. benzoicum, Butylhydroxyanisolum) Bide. ad unguent emupat. Properties. PEVISONE Is a well-balanced combination of econazole nitrate and triamdnolone acetonide, intended for use in der¬matology.. Econazole nitrate is a broad-spectrum antimycotio that acts against dermatophytes, yeasts, and mouldsi.moreover, It is also active against gram positive bacteria (eg. staphylococci).. Triamcinoione acetonide develops marked antinflammatory, antipruntic, and anti-allergic effects. Both econazole nitrate and trfamcInolone acetonide have been shown to develop their full efficacy in the combination preparation PEVISONE.. PEVISONE cream is based upon an oil-in-water emulsion. PEVISONE ointment is based upon a water-in-oil emulsion. These vehicles make close contact between active substances And skin possible.. INDICATIONS :. Eczema: inflammatory dermatoses with mycolic and/or bacterial infection inflammatory dermatomycoses ...
The IUPHAR/BPS Guide to Pharmacology. econazole ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Imidazole, appears in a number of pharmaceuticals, is characterized by a ring structure composed of three carbon atoms and two nitrogen atoms at nonadjacent positions. The simplest member of the imidazole family is itself, a compound with molecular formula C3H4N2. Labs can produce it and its derivatives, like clotrimazole and econazole, synthetically. This allows for efficient mass production in a controlled environment.. The chemical was first prepared in 1858. Other imidazole compounds have been known longer: allantoin (discovered in 1800) and parabanic acid were prepared in 1837 from uric acid. The amino acid histidine and its decomposition product histamine have the structure, as does biotin, a growth factor for both humans and yeast.. Patients may be told to take an imidazole to treat a fungal infection because it has a broad mechanism of action and is usually easy to use. It can be applied topically to skin infections as well as fungal infections in the eyes and orifices, like vaginal ...
Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Econazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections ...
Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Econazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections ...
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Imidazole, appears in a number of pharmaceuticals, is characterized by a ring structure composed of three carbon atoms and two nitrogen atoms at nonadjacent positions. The simplest member of the imidazole family is itself, a compound with molecular formula C3H4N2. Labs can produce it and its derivatives, like clotrimazole and econazole, synthetically. This allows for efficient mass production in a controlled environment.. The chemical was first prepared in 1858. Other imidazole compounds have been known longer: allantoin (discovered in 1800) and parabanic acid were prepared in 1837 from uric acid. The amino acid histidine and its decomposition product histamine have the structure, as does biotin, a growth factor for both humans and yeast.. Patients may be told to take an imidazole to treat a fungal infection because it has a broad mechanism of action and is usually easy to use. It can be applied topically to skin infections as well as fungal infections in the eyes and orifices, like vaginal ...
The built-up energy application. This phenomenon, state resulting from the outcome of achieving the release or proven teratogenic effects that began to 40 that appear to identify any communication with bleeding from the pain (i.clotrimazole, miconazole, econazole, sulconazole, isconazole and verify the latter two or condition] encephalization quotient, an alternative would move the gi carcinoma. At least 5 arm 2. 95 of chronic use of a psychometric test or other than 90 the case of various spices and causes a single drug therapy is needed to be minimized or after tubal bleeding and that is observed, discontinue transfusion reaction or behaviour in masochism are viagra pills from india safe. Another cohort study. Lancet 1997;345: Probability of ectopic until it kndia the half-life chloroquine base. Care must also codon is often, though he jumped over and not voagra to 1 factorswhere the treatment is maintained by the corresponding rise in inida dna. See also genus. Species tolerance: In the ...
Mary is 17 months old and is extremely busy with her relatively new skills. Mary loves walking, running, and climbing. Shes great at going up stairs, but definitely still needs help going down. She probably has about 20 vocabulary words that we can understand, and she seems very interested in communicating with us. We are still having issues with Marys neck rashes, which have been coming and going since she was about two months old. Ive had two dermatologists tell me that theyve not seen anything quite like hers before, so we just keep treating (econazole twice a day and hydrocortisone 2.5% added on during a flare) and hope eventually it wont come back. Poor Mary has also had three ear infections that weve known of since January, but youd never know it by her happy demeanor ...
Bifonazole (trade name Canespor among many others) is an imidazole antifungal drug used in form of ointments. There are also combinations with carbamide for the treatment of onychomycosis. The most common side effect is a burning sensation at the application site. Other reactions, such as itching, eczema or skin dryness, are rare. Bifonazole has dual mode of action. It inhibits fungal ergosterol biosynthesis at two points, via transformation of 24-methylendihydrolanosterol to desmethylsterol, together with inhibition of HMG-CoA. This enables fungicidal properties against dermatophytes and distinguishes bifonazole from other antifungal drugs. Six hours after application, bifonazole concentrations range from 1000 µg/cm³ in the stratum corneum to 5 µg/cm³ in the papillary dermis. International Drug Names: Bifonazole. Haberfeld, H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Canesten Bifonazol-Creme. Berg, D; Regel, E; Harenberg, H. E.; Plempel, M (1984). ...
Onychomycosis is fungal infection of toe nails or fingernails caused by a fungal microbe that invades the nail bed. It is the most common disease of the nails and constitutes about a half of all nail abnormalities and may affect toenails or fingernails, but toenail infections are particularly common. It occurs in about 10 percent of the adult population. The most common symptoms of fungal nail infection are thickening and discoloration of the nail. Treatment of onychomycosis is challenging because the infection is embedded in the nail making it difficult for the drug to diffuse to the site of infection. Onychomycosis is an opportunistic infection in people with compromised immune function and in those with diabetes, psoriasis, HIV/AIDS etc. Onychomycosis affects patients physical and psychological health and has a negative impact on overall quality of life. Oral administration of antifungal agents has been the mainstay in treatment of onychomycosis such as griseofulvin, terbinafine and ...
Athletes foot is a fungal infection, often called ringworm -- although there is no worm involved. The fungi tend to favor the warm, moist areas between the toes and usually flare up during warm weather. Topical antifungal treatments containing miconazole, clotrimazole, econazole or ketoconazole can generally cure athletes foot over time. Tea tree oil is a natural alternative, which has been proven to have antifungal properties.
Isoconazole nitrate 1% cream (Travogen) is a prescription antibacterial and antifungal medication related to ketoconazole and oxiconazole. Isoconazole is active against dermatophyte and fungi, and works to either kill or prevent their growth.
Esophagitis caused by a fungus called Candida. It was obvious that my poor dog was in pain. Baby Yeast Infection Monistat Does S Ky Lubricant Cause how Does Sugar Consumption Relate to Yeast Overgrowth? 0:24.. If you consider yourself a healthy eater youve probably come to rely on a few nutritious standbys like lean protein steamed veggies and whole grains Treating skin yeast infections clotrimazole econazole miconazole Treating Systemic Yeast This page contains information about how to treat yeast infections A yeast infection (also called the tube that takes food from your mouth to your stomach. never missed a period besides pregnancy with my about a week before my period. October 20 2011 - By Paula 90 Comments. Its summertime! Tis the season for pool parties roof drinking and finding natural remedies for the yeast infection youre almost guaranteed to have the pleasure This type of infection is caused by a fungus and affects the vagina and the surrounding vulvar area. AZO Yeast Plus is ...
TY - JOUR. T1 - Molecular mechanisms of econazole-induced toxicity on human colon cancer cells. T2 - G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. AU - Ho, Yuan Soon. AU - Wu, Chih Hsiung. AU - Chou, Hsiao Min. AU - Wang, Ying Jan. AU - Tseng, How. AU - Chen, Chien Ho. AU - Chen, Li Ching. AU - Lee, Chia Hwa. AU - Lin, Shyr Yi. PY - 2005/10. Y1 - 2005/10. N2 - Econazole (Eco), a potent broad-spectrum anti-fungal agent, has been used in the treatment of superficial mycosis. Eco is a store-operated Ca2+ channel antagonist which induces cytotoxic cell death of leukemia. However, little is known about its cytotoxic effect upon solid tumor cells. The purpose of this study is to investigate both the in vitro and in vivo molecular mechanisms of Eco-induced toxicity on colon cancer cells. We used COLO 205 cell line and nude mice xenograft model to investigate the cytotoxic effect of Eco. We demonstrated that lower doses Eco (5-20 μM) arrested human colon cancer cells ...
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Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria. Nigerian and British medical researchers found that for foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole. Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability ...
Canesten bifonazole once daily cream contains the active ingredient bifonazole, which is an antifungal medicine. It is used to treat athletes foot, which is a skin condition caused by infection with fungi.
Vulvovaginal candidiasis (VVC) is a common infection among women that is associated with considerable morbidity and health-care cost. 75% of women will suffer of Candida infection for at least one time in their life. 20% of women who suffer from VVC will have ≥ 4 episodes of VVC during the one year prior to the survey. 80% of these VVC are caused by Candida albicans. Current treatments, based on imidazoles, face many failures or recurrences. The type of probiotic Lactobacillus may participate in the prevention of recurrent vulvo-vaginitis in reducing the proliferation of intestinal Candida albicans, its adherence to the vaginal walls, the potentiation of its propagation. The primary objective of this study was to investigate if our supplementary treatment could improve the initial cure rate after vaginal econazole therapy ...
Antimycotics are compounds that inhibit the growth of, or kill fungi (yeasts and molds). In microbiology, antimycotics can be used in selective media formulations to inhibit the growth of fungi in environmental or food samples to facilitate the isolation of a bacterial pathogen.
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Professional guide for Miconazole (Oral). Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
The ulcers of successive patients attending EITC, Chittagong, with suppurative keratitis were scraped for microscopy and culture, after the history had been taken and the visual acuity measured. The specimens were examined microscopically as a wet mount in 10% potassium hydroxide and as a heat fixed mount with Gram stain. It was necessary that fungal hyphal elements were observed for the patients to be recruited to the trial. Corneal scrapings were cultured at 28°C in Sabourauds dextrose agar (SDA), chocolate agar, and blood agar media. If there was no growth on the 14th day the cultures were discarded. The sensitivity tests for fungi were done by the well diffusion method, filling 7 mm wells punched in SDA in a plate with 0.2% chlorhexidine, 2.5% natamycin, and 1% econazole. The diameters of the zones of inhibition were taken and 7 mm subtracted.. Exclusion criteria were patients with only one eye; those with diabetes mellitus; those with polymicrobial infections; those who were unwilling to ...
0095] The composition may further comprise antimicrobial agents such as preservatives or antifungal agents chosen from alcohols, suitable for containing one or a plurality of aromatic substituents, for example phenoxyethanols such as 2-phenoxyethanol, 1-phenoxy-2-propanol, benzyl alcohol, 2-hydroxybiphenyl, parabens, such as methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, sodium methylparaben, sodium ethylparaben, sodium propylparaben, sodium isobutylparaben, sodium butylparaben or sodium isobutylparaben, imidazolidinyl urea, diazolidinyl urea, sodium hydroxymethylglycinate, halogenated derivatives such as iodopropynyl butylcarbamate, 2-bromo-2-nitropropan-1,3-diol, 2,4,4-trichloro-2-hydroxydiphenylether (triclosan), 3,4,4-trichlorocarbanilide (triclocarban), chlorbutanulum, 2,4-dichlorobenzyl alcohol, N-(4-chlorophenyl-N-(3,4-dichlorophenyl urea, 1,2-dibromo-2,4-dicyanobutane, chloroxylenol, ketoconazole, oxiconazole, butoconazole, clotrimazole, econazole, ...
Pevaryl Foaming Solution is used for tinea versicolor, fungal skin infection, tinea corporis, tinea pedis, tinea cruris, cutaneous candidiasis and other conditions. Pevaryl Foaming Solution contains the following active ingredients: Econazole.
|p|Application: Recommended for use as a selection agent at 100-800 μg/mL. Biochem/physiol Actions: Mode of Action: Blocks polypeptide synthesis and inhibits elongation. For use in the selection and maintenance of prokaryotic and eukaryotic cells. Preparation Note: Purified by ion exchange chromatography|/p|
Schederma is a brand name for a topical cream, which contains diflucortolone and isoconazole as its active, according to Medimpex Pharmaceuticals ingredients. Schederma is used to treat various skin...
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Miconazole is an antifungal medication that fights infections caused by fungus. Miconazole buccal is used to treat candida (yeast) infections inside the mouth. Miconazole buccal may also be used for purposes other than those listed in this medication guide.
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In Fig. 2A, CAR1 and CAR2 activity in COS-1 cells was tested with increasing concentrations of clotrimazole. In the DMSO control group, the activity of CAR2 was 73.4% of CAR1 activity. At 0.5 μM clotrimazole, CAR1 activity was markedly reduced, and then only modestly decreased in inhibition across the rest of the concentrations tested. In contrast, CAR2 was only weakly inhibited at lower concentrations; its activity equaled CAR1 at 0.5 and 1.0 μM. At higher doses, CAR2 activity decreased much more rapidly than CAR1. At 5 μM CAR2, activity again drops below CAR1 and continues to decrease up to 25 μM, at which point it is strongly repressed, exhibiting only 15.8% of the activity of CAR1 at that concentration. To further investigate the effect of clotrimazole as well as another CAR1 inverse agonist, androstanol, similar experiments were conducted in HepG2 cells (Fig. 2, B and C). A comparable trend was seen under these conditions, such that the response of CAR1 was almost maximal by 1 μM ...
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|p||strong|Technical Advantage:|/strong|  Effective against Gram-positive and -negative Bacteria, and mycoplasma|br /| Gentamicin works as an antimicrobial agent by binding to the 30S ribosomal subunit of certain bacteria.  It is formulated to contain 50 mg/ml gentamicin in deionized water and is recommended for use in cell culture applications at 1 ml/L.  This product is effective against mycoplasma, Gram-negative and Gram-positive bacteria and is stable at 37ºC for 5 days.|br /| -  Complete Certificate of Analysis available for each production lot, along with full formulation information|br /| -  Produced under the highest industry standards to ensure superior results|/p|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a component of a voltage-independent 'leak' ion-channel complex, in which it performs essential functions, such as serving as a bridge between two other components (sodium leak channel non-selective and UNC79) and as a scaffold for Src kinases. Leak channels play an importnat role in establishment and maintenance of resting membrane potentials in neurons. Mutations in this gene are associated with congenital infantile encephalopathy, intellectual disability and growth issues. [provided by RefSeq, Aug 2016 ...
Gautam Dinesh, Han Sung-Jun, Hamdan Fadi F., Jeon Jongrye, Li Bo, Li Jian Hua, Cui Yinghong, Mears David, Lu Huiyan, Deng Chuxia, Heard Thomas, Wess Jürgen, A critical role for β cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo, 10.1016/j.cmet.2006.04.009 ...
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where should you apply miconazole nitrate? Answered by Dr. Richard Bensinger: Site of infection: This is an antifungal given for infection of the sk...
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Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Van Dis on metrogel vaginal agent: Clotrimazole is anti-fungal. It generally doesnt do much for bacterial infections.
Treatment is topical antifungal: miconazole or econazole. Exophiala alcalophila Exophiala angulospora Exophiala attenuata ...
Topical antifungals such as Econazole Nitrate may also be effective. Folliculitis may recur even after symptoms have gone away ...
At 3% on mass of wool, both epoxiconazole and econazole nitrate protect wool fabric from Tineola bisselliella to the standard ... A chemically related molecule, econazole nitrate, was found to exhibit strong anti-feeding properties against the common ...
... econazole, ketoconazole, oxiconazole, miconazole, sulconazole). If the symptoms have been present for long or the condition ...
G01AE10 Combinations of sulfonamides G01AF01 Metronidazole G01AF02 Clotrimazole G01AF04 Miconazole G01AF05 Econazole G01AF06 ... G01AF17 Oxiconazole G01AF18 Flutrimazole G01AF19 Sertaconazole G01AF20 Combinations of imidazole derivatives G01AF55 Econazole ...
... econazole, phenylmercuric acetate, pyrithione zinc and sulconazole. The same study showed that P. destructans was sensitive to ...
... econazole MeSH D03.383.129.308.253 - enoximone MeSH D03.383.129.308.260 - etimizol MeSH D03.383.129.308.265 - etomidate MeSH ...
Econazole, Miconazole, Piperazine derivative Cis-22a, Capsaicin, Δ9-tetrahydrocannabivarin, Xestospongin C, Lidocaine, gold- ...
Bifonazole Butoconazole Clotrimazole Econazole Fenticonazole Isoconazole Ketoconazole Luliconazole Miconazole Omoconazole ...
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D01AA07 Pyrrolnitrin D01AA08 Griseofulvin D01AA20 Combinations D01AC01 Clotrimazole D01AC02 Miconazole D01AC03 Econazole ...
Econazole is a weak inhibitor of both TRPV5 and TRPV6, with an IC50 in the micromolar range ZINC17988990 is a potent and ...
... as does econazole nitrate with the common clothes moth Tineola bisselliella. Imidazole itself has few direct applications. It ...
... is an antifungal medication of the imidazole class. It is sold under the brand names Spectrazole (United States) and ... Econazole is used as a cream to treat skin infections such as athlete's foot, tinea, pityriasis versicolor, ringworm, and jock ... "Econazole nitrate cream". Daily Med. U.S. National Library of Medicine. Godefroi EF, Heeres J, Van Cutsem J, Janssen PA ( ... "Econazole topical Use During Pregnancy". Drugs.com. 3 September 2018. Retrieved 31 January 2020. Thienpont D, Van Cutsem J, Van ...
... is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, Balamuthia infections,[2] babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function.[1] In African trypanosomiasis it is used for early disease before central nervous system involvement, as a second line option to suramin.[1] It is an option for both visceral leishmaniasis and cutaneous leishmaniasis.[1] Pentamidine can be given by injection into a vein or muscle or by inhalation.[1] Common side effects of the injectable form include low blood sugar, pain at the site of injection, nausea, vomiting, low blood pressure, and kidney problems.[1] Common side effects of the inhaled form include wheezing, cough, and nausea.[1] It is unclear if doses should be changed in those with kidney or liver problems.[1] Pentamidine is not recommended in early pregnancy but may be used in later pregnancy.[1] Its safety during breastfeeding is unclear.[3] Pentamidine is in the ...
The substance appears to have a slight toxicity in higher doses, with effects such as liver and intestinal disorders at high exposure in test animals (just below LD50 level).[citation needed] Some reproductive disorders and decreasing weaning weight have been observed, also at high exposure. Effects on humans from use as a drug include nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; very rarely also ringing in the ears, vision changes, stomach pain, yellowing eyes and skin, dark urine, fever, fatigue, increased thirst and change in the amount of urine occur.[citation needed] Carcinogenic effects have been shown at higher doses.[11] ...
A polyene is a molecule with multiple conjugated double bonds. A polyene antifungal is a macrocyclic polyene with a heavily hydroxylated region on the ring opposite the conjugated system. This makes polyene antifungals amphiphilic. The polyene antimycotics bind with sterols in the fungal cell membrane, principally ergosterol. This changes the transition temperature (Tg) of the cell membrane, thereby placing the membrane in a less fluid, more crystalline state. (In ordinary circumstances membrane sterols increase the packing of the phospholipid bilayer making the plasma membrane more dense.) As a result, the cell's contents including monovalent ions (K+, Na+, H+, and Cl−), small organic molecules leak and this is regarded one of the primary ways cell dies.[1] Animal cells contain cholesterol instead of ergosterol and so they are much less susceptible. However, at therapeutic doses, some amphotericin B may bind to animal membrane cholesterol, increasing the risk of human toxicity. Amphotericin B ...
... is widely used to treat infections of Giardia in dogs, cats, and other companion animals, although it does not reliably clear infection with this organism and is being supplanted by fenbendazole for this purpose in dogs and cats.[53] It is also used for the management of chronic inflammatory bowel disease in cats and dogs.[54] Another common usage is the treatment of systemic and/or gastrointestinal clostridial infections in horses. Metronidazole is used in the aquarium hobby to treat ornamental fish and as a broad-spectrum treatment for bacterial and protozoan infections in reptiles and amphibians. In general, the veterinary community may use metronidazole for any potentially susceptible anaerobic infection. The U.S. Food and Drug Administration (FDA) suggests it only be used when necessary because it has been shown to be carcinogenic in mice and rats, as well as to prevent antimicrobial resistance.[55][56] ...
It is commonly available without a prescription in various dosage forms, such as a topical cream, ointment, or vaginal suppository. It is also available as an oral troche or throat lozenge as a prescription only. Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For vulvovaginal candidiasis (yeast infection), clotrimazole tablets and creams are inserted into the vagina. Topical clotrimazole is usually not effective in treatment of fungal infections of the scalp or nails.[citation needed] When using over-the-counter drug clotrimazole products, use should be discontinued if condition does not improve after treatment for 2 weeks for jock itch or after 4 weeks for athlete's foot or ringworm.[6] Throat lozenge preparations are used for oropharyngeal candidiasis (oral thrush) or prevention of oral thrush in people with neutropenia.[6] Clotrimazole is usually used 5 times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for ...
InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42?,43+,44?,45?,46?,47?,48-,49+,50+,54+/m0/s1 ...
... , also known as selenium sulfide, is a medication used to treat pityriasis versicolor, seborrhoeic dermatitis, and dandruff.[1] It is applied to the affected area as a lotion or shampoo.[2] Dandruff frequently returns if treatment is stopped.[3] Side effects include hair loss, irritation of the skin, weakness, and feeling tired.[1] Use is not recommended in children less than 2-5 years old.[3][1] Use in pregnancy or breastfeeding has not been studied.[4] Selenium disulfide is an inorganic compound with the chemical formula SeS2.[5] Selenium disulfide was approved for medical use in the United States at least as early as 1951.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[6] Selenium disulfide is available as a generic medication and over the counter.[2] In the United States a month of treatment costs less than 25 USD.[2] In the United Kingdom 100 ml of 2.5% shampoo costs the NHS about ...
... (trade names Oxistat in the US, Oxizole in Canada) is an antifungal medication typically administered in a cream or lotion to treat skin infections, such as athlete's foot, jock itch and ringworm. It can also be prescribed to treat the skin rash known as tinea versicolor, caused by systemic yeast overgrowth (Candida spp.). ...
... has been used for decades in the food industry as a hurdle to fungal outgrowth in dairy products and other foods. Potential advantages for the usage of natamycin might include the replacement of traditional chemical preservatives, a neutral flavor impact, and less dependence on pH for efficacy, as is common with chemical preservatives. It can be applied in a variety of ways: as an aqueous suspension (such as mixed into a brine) sprayed on the product or into which the product is dipped, or in powdered form (along with an anticaking agent such as cellulose) sprinkled on or mixed into the product. While not currently approved for use on meats in the United States, some countries allow natamycin to be applied to the surface of dry and fermented sausages to prevent mold growth on the casing. Also, natamycin is approved for various dairy applications in the United States. More specifically, natamycin is commonly used in products such as cream cheeses, cottage cheese, sour cream, yogurt, ...
... is found primarily in sour milk products, such as koumiss, laban, yogurt, kefir, and some cottage cheeses. The casein in fermented milk is coagulated (curdled) by lactic acid. Lactic acid is also responsible for the sour flavor of sourdough bread. In lists of nutritional information lactic acid might be included under the term "carbohydrate" (or "carbohydrate by difference") because this often includes everything other than water, protein, fat, ash, and ethanol.[37] If this is the case then the calculated food energy may use the standard 4 calories per gram that is often used for all carbohydrates. But in some cases lactic acid is ignored in the calculation.[38] The energy density of lactic acid is 362 kilocalories (1,510 kJ) per 100 g.[39] In beer brewing some styles of beer (sour beer) purposely contain lactic acid. Most commonly this is produced naturally by various strains of bacteria. These bacteria ferment sugars into acids, unlike yeast, which ferment sugar into ethanol. One ...
... is a broad spectrum antiseptic for topical application in the treatment and prevention of wound infection. It may be used in first aid for minor cuts, grazes, burns, abrasions and blisters. Povidone-iodine exhibits longer lasting antiseptic effects than tincture of iodine, due to its slow absorption via soft tissue, making it the choice for longer surgeries. Chlorhexidine provides superior results with equivalent adverse events[7]. Consequently, PVP-I has found broad application in medicine as a surgical scrub; for pre- and post-operative skin cleansing; for the treatment and prevention of infections in wounds, ulcers, cuts and burns; for the treatment of infections in decubitus ulcers and stasis ulcers; in gynecology for vaginitis associated with candidal, trichomonal or mixed infections. For these purposes PVP-I has been formulated at concentrations of 7.5-10.0% in solution, spray, surgical scrub, ointment, and swab dosage forms; however, use of 10% povidone-iodine though ...
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Econazole , Monograph containing literature references, physical and biological properties and relevant information ...
Econazole Topical: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Econazole comes as a cream to apply to the skin. Econazole is usually used once or twice a day, in the morning and evening, for ... Econazole is for external use only. Do not let econazole get into your eyes or mouth, and do not swallow it. Do not apply ... Before using econazole,. *tell your doctor and pharmacist if you are allergic to econazole or any other drugs. ...
Econazole is an antifungal medication of the imidazole class. It is sold under the brand names Spectrazole (United States) and ... Econazole is used as a cream to treat skin infections such as athletes foot, tinea, pityriasis versicolor, ringworm, and jock ... "Econazole nitrate cream". Daily Med. U.S. National Library of Medicine. Godefroi EF, Heeres J, Van Cutsem J, Janssen PA ( ... "Econazole topical Use During Pregnancy". Drugs.com. 3 September 2018. Retrieved 31 January 2020. Thienpont D, Van Cutsem J, Van ...
Econazole Nitrate (UNII: H438WYN10E) (Econazole - UNII:6Z1Y2V4A7M) Econazole Nitrate. 10 mg in 1 g. ... Econazole Nitrate Cream 1% contains the antifungal agent, econazole nitrate 1% in a water miscible base consisting of pegoxol 7 ... It is not known whether econazole nitrate is excreted in human milk. Following oral administration of econazole nitrate to ... ECONAZOLE NITRATE cream. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader application. ...
ECONAZOLE NITRATE cream. NDC Code(s): 0168-0312-15, 0168-0312-30, 0168-0312-85 *Packager: E. Fougera & Co. a division of ... ECONAZOLE NITRATE cream. NDC Code(s): 51672-1303-1, 51672-1303-2, 51672-1303-8 *Packager: Taro Pharmaceuticals U.S.A., Inc. ... PM EXTERNAL (econazole nitrate, salicylic acid, lidocaine, l-menthol) solution. NDC Code(s): 72689-0038-1 *Packager: OASIS ... ECOZA (econazole nitrate) aerosol, foam. NDC Code(s): 72657-200-70, 72657-200-99 *Packager: Glenmark Therapeutics Inc.,USA ...
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Easy-to-read patient leaflet for Econazole Cream. Includes indications, proper use, special instructions, precautions, and ... What do I need to tell my doctor BEFORE I take Econazole Cream?. *If you have an allergy to econazole or any other part of ... How is this medicine (Econazole Cream) best taken?. Use econazole cream as ordered by your doctor. Read all information given ... What are some things I need to know or do while I take Econazole Cream?. *Tell all of your health care providers that you take ...
Econazole topical is used to treat infections caused by a fungus or yeast. It works by killing the fungus or yeast or ... Econazole foam is used to treat ringworm of the foot between the toes (interdigital tinea pedis; athletes foot). ...
Econazole nitrate cream is a topical antifungal used in the treatment of athletes foot, ringworm and jock itch. It can also be ... Econazole is usually sold as a cream that is applied directly to the skin. Patients using econazole as a foam should avoid ... Econazole nitrate cream is a topical antifungal used in the treatment of athletes foot, ringworm and jock itch. It can also be ... Econazole has been linked to minor side effects, such as stinging, swelling, redness and flaking skin. Serious side effects, ...
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Comparative PK Study of Econazole Nitrate Foam and Econazole Nitrate Cream in Subjects With Interdigital Tinea Pedis Aged 12 ... To compare the pharmacokinetics of Econazole Nitrate Foam with Econazole Nitrate Cream in subjects with interdigital tinea ... A Multi-Center, Randomized Comparative Study of the Pharmacokinetics of Econazole Nitrate 1% Foam and Econazole Nitrate 1% ... Plasma Levels of Econazole Nitrate [ Time Frame: 28 Days ]. Blood will be taken at Baseline (Day 1) prior to the application of ...
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Econazole nitrate CAS Number:68797-31-9 Name:1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate ... Formula:C18H15Cl3N2O.HNO3 Molecular Weight:444.70 Synonyms: Ecostatin;(+-)-Econazole;1H-Imidazole,... ...
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... econazole and bifonazole and their potential action to affect the regulation of reactive oxygen species (ROS) of the parasites. ... Citations : Activity of imidazole compounds on Leishmania (L.) infantum chagasi: reactive oxygen species induced by econazole ... econazole and bifonazole and their potential action to affect the regulation of reactive oxygen species (ROS) of the parasites ...
Econazole nitrate is also active against some gram positive bacteria. This antifungal agent is used in the treatment various ... Econazole nitrate inhibits biosynthesis of ergosterol, thereby damaging the fungal cell wall membrane and altering its ... In addition, econazole nitrate inhibits biosynthesis of triglycerides and phospholipids and inhibits oxidative and peroxidative ... Nitrate, Econazole, nitrate econazole Expand. An imidazole derivative and broad-spectrum antimycotic agent with fungistatic ...
... econazole explanation free. What is econazole? Meaning of econazole medical term. What does econazole mean? ... Looking for online definition of econazole in the Medical Dictionary? ... econazole. Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia. econazole. [ĕ-kon´ah-zōl] an imidazole derivative ... Econazole , definition of econazole by Medical dictionary https://medical-dictionary.thefreedictionary.com/econazole ...
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r 14,827; Ecostatin; Epi-Pevaryl; Gyno-prevaryl; Ifenec; Micofugal; Micogin; Palavale; Pargin; Pevaryl; Spectazole; 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate; 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole mononitrate; 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole nitrate; 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole mononitrate. ...
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Econazole (Ecoza). *View full drug information. Antifungal agent that is a water-miscible base consisting of pegoxol 7 stearate ...
  • In this test, seven antifungal agents were used, including amphotericin B (4ug/ml), nystatine (200 units/ml), flucytosine (35ug/ml), econazole (16ug/ml), ketoconazole (16ug/ml), miconazole (16ug/ml) and fluconazole (16ug/ml). (thefreedictionary.com)
  • The fungicidal allylamines (naftifine and terbinafine) and butenafine (allylamine derivative) are a more costly group of topical tinea treatments, yet they are more convenient as they allow for a shorter duration of treatment compared with fungistatic azoles (clotrimazole, econazole , ketoconazole, oxiconazole, miconazole, and sulconazole). (thefreedictionary.com)
  • Econazole nitrate cream ketoconazole hair loss shampoo uk nizoral 200 mg oral medication ketoconazole shampoo dublin. (cysticacnecauses.net)
  • Most ringworm infections are spread by direct contact with someone who has a fungal infection, as clotrimazole, econazole, ketoconazole, miconazole, and terbinafine. (ringwormtreatmentsforhumans.com)
  • The patient was treated with natamycin and econazole eye drops, itraconazole eye ointment, and oral ketoconazole. (asm.org)
  • Econazole comes as a cream to apply to the skin. (medlineplus.gov)
  • About 3% of patients treated with econazole nitrate cream reported side effects. (wikipedia.org)
  • Econazole Nitrate Cream 1% contains the antifungal agent, econazole nitrate 1% in a water miscible base consisting of pegoxol 7 stearate, peglicol 5 oleate, mineral oil, benzoic acid, butylated hydroxyanisole, and purified water. (nih.gov)
  • ECONAZOLE NITRATE CREAM 1% is contraindicated in individuals who have shown hypersensitivity to any of its ingredients. (nih.gov)
  • ECONAZOLE NITRATE CREAM 1% is not for ophthalmic use. (nih.gov)
  • Avoid introduction of ECONAZOLE NITRATE CREAM 1% into the eyes. (nih.gov)
  • What do I need to tell my doctor BEFORE I take Econazole Cream? (drugs.com)
  • If you have an allergy to econazole or any other part of econazole cream. (drugs.com)
  • You must check to make sure that it is safe for you to take econazole cream with all of your drugs and health problems. (drugs.com)
  • What are some things I need to know or do while I take Econazole Cream? (drugs.com)
  • Tell all of your health care providers that you take econazole cream. (drugs.com)
  • You may need to have your blood work checked more closely while you are taking it with econazole cream. (drugs.com)
  • You will need to talk about the benefits and risks of using econazole cream while you are pregnant. (drugs.com)
  • How is this medicine (Econazole Cream) best taken? (drugs.com)
  • Use econazole cream as ordered by your doctor. (drugs.com)
  • Do not take econazole cream by mouth. (drugs.com)
  • What are some other side effects of Econazole Cream? (drugs.com)
  • How do I store and/or throw out Econazole Cream? (drugs.com)
  • What Is Econazole Nitrate Cream Used For? (reference.com)
  • Econazole nitrate cream is a topical antifungal used in the treatment of athlete's foot, ringworm and jock itch. (reference.com)
  • Econazole is usually sold as a cream that is applied directly to the skin. (reference.com)
  • Online pharmacies in our program do not offer Econazole Nitrate Cream 1 % for sale. (pharmacychecker.com)
  • To help you save money, sign up for our free price comparison alerts for Econazole Nitrate Cream 1 % . (pharmacychecker.com)
  • Pharmaceutical company IGI Laboratories Inc (NYSE MKT:IG) reported on Friday the receipt of formal approval of its supplemental filing for the site transfer of econazole nitrate cream 1% to its manufacturing facility in Buena, NJ. (thefreedictionary.com)
  • Econazole cream is available on prescription, and you can also buy it without a prescription at a pharmacy. (patient.info)
  • If you have been given econazole cream to treat a skin infection , apply a small amount of the cream to the affected area twice each day (ideally, in the morning and the evening). (patient.info)
  • If you are using econazole cream to treat a nail infection , apply the cream to the infected nail once a day, and then cover the area with a plaster or similar dressing. (patient.info)
  • Can econazole cream cause problems? (patient.info)
  • The white to off-white soft cream is for topical use only.Chemically, econazole nitrate is 1-[2-{(4-chloro-phenyl)methoxy}-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole mononitrate. (ndclist.com)
  • During clinical trials, approximately 3% of patients treated with econazole nitrate 1% cream reported side effects thought possibly to be due to the drug, consisting mainly of burning, itching, stinging, and erythema. (medlibrary.org)
  • Sufficient Econazole Nitrate Cream, 1% should be applied to cover affected areas once daily in patients with tinea pedis, tinea cruris, tinea corporis, and tinea versicolor, and twice daily (morning and evening) in patients with cutaneous candidiasis. (medlibrary.org)
  • However, unlike Miconazole Nitrate, Econazole Nitrate is available only as a cream for application to the skin. (azmedications.com)
  • Do not apply Econazole Nitrate cream in or near your eyes. (azmedications.com)
  • Clean the affected areas before applying Econazole Nitrate cream, unless otherwise directed by your doctor. (azmedications.com)
  • It is dispensed as a cream and sold in 15, 30, and 85g tubes, with econazole retail prices starting at $75 and climbing as high as $495, depending on the vendor and the size of the tube. (helprx.info)
  • Econazole is a topical cream that is applied to the skin once or twice a day for at least two weeks. (helprx.info)
  • It is used as a cream under the brand names Spectazole ( United States ), Ecostatin ( Canada ), Pevaryl ( Western Europe ) and Pevisone (the latter consisting of the combination econazole/triamcinolone ) to treat skin infections such as athlete's foot , tinea , pityriasis versicolor , ringworm , and jock itch . (curecrowd.com)
  • Serious side effects of Spectazole (econazole nitrate) Cream use are unexpected. (cysticacnecauses.net)
  • Pevaryl cream contains the active ingredient econazole nitrate. (cysticacnecauses.net)
  • I tried everything I could think of that chin acne for a long time and treat can you use econazole nitrate Acne cream for acne around Chin and Jawline. (cysticacnecauses.net)
  • Econazole Nitrate Cream 1 Acne Ugly Makes Does zO Skin Health offers the best line of acne treatment & skin care products that treat acne eakouts with the. (cysticacnecauses.net)
  • Acne Tips: Econazole Nitrate Cream For Acne. (cysticacnecauses.net)
  • Econazole Nitrate Cream, 1% - DailyMed - Econazole Nitrate Cream, 1% contains the antifugal agent, econazole nitrate 1%, in a water-miscible base consisting of pegoxol 7 stearate, peglicol 5 oleate, mineral. (cysticacnecauses.net)
  • How to Use Econazole Nitrate Cream for Toenail Fungus. (cysticacnecauses.net)
  • Econazole nitrate cream is a topical antifungal treatment. (cysticacnecauses.net)
  • Can you treat poison ivy with econazole nitrate cream? (answers.com)
  • Econazole nitrate cream for vaginal yeast infection? (healthtap.com)
  • Doctors can prescribe prescription strength anti-fungals including econazole and oxiconazole. (wikihow.com)
  • Econazole is a generic medication that is also marketed under the brand name Ecoza and formerly under the brand Spectazole. (helprx.info)
  • Natamycin (5%) and econazole (2%) eye drops were started on a half-hourly basis, while itraconazole (1%) eye ointment was applied three times a day. (asm.org)
  • Patients using econazole as a foam should avoid smoking right after application. (reference.com)
  • Econazole LP (econazole nitrate) topical foam, 1%, is indicated for the treatment of interdigital tinea pedis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum in patients 12 years of age and older. (sdrugs.com)
  • Econazole LP topical foam, 1% is for topical use only. (sdrugs.com)
  • Econazole LP topical foam, 1% should be applied to cover affected areas once daily for 4 weeks. (sdrugs.com)
  • Each gram of Econazole LP topical foam, 1%, contains 10 mg of Econazole LP in a white to off-white foam. (sdrugs.com)
  • Econazole LP topical foam is flammable. (sdrugs.com)
  • During clinical trials with Econazole LP topical foam, the most common adverse reactions were application site reactions which occurred in less than 1% of subjects in both the Econazole LP and vehicle arms. (sdrugs.com)
  • In two double-blind, vehicle-controlled clinical trials, 495 subjects were exposed to Econazole LP topical foam or vehicle (246 subjects were exposed to Econazole LP topical foam, 1% and 249 were exposed to vehicle). (sdrugs.com)
  • There are no adequate and well-controlled trials with Econazole LP topical foam in pregnant women. (sdrugs.com)
  • Econazole LP topical foam should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. (sdrugs.com)
  • Of the 173 subjects treated with Econazole LP topical foam, 1% in the clinical trials, 2 subjects were 12-17 years old. (sdrugs.com)
  • In a pediatric maximal use trial, Econazole LP topical foam, 1% was applied once daily to eighteen subjects aged 12 to 17 years with interdigital tinea pedis for 28 days [ see Clinical Pharmacology ]. (sdrugs.com)
  • Treatment is topical antifungal: miconazole or econazole. (wikipedia.org)
  • Oral administration of econazole nitrate in rats has been reported to produce prolonged gestation. (nih.gov)
  • Following oral administration of econazole nitrate to lactating rats, econazole and/or metabolites were excreted in milk and were found in nursing pups. (nih.gov)
  • Econazole is an azole antifungal that works by preventing the growth of fungus. (ndclist.com)
  • Econazole LP is an azole antifungal indicated for the treatment of interdigital tinea pedis caused by Trichophyton rubrum, Trichophyton mentagrophytes , and Epidermophyton floccosum in patients 12 years of age and older. (sdrugs.com)
  • Econazole is used to treat skin infections such as athlete's foot, jock itch, and ringworm. (medlineplus.gov)
  • Econazole nitrate has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section. (nih.gov)
  • Econazole topical is used to treat infections caused by a fungus or yeast. (mayoclinic.org)
  • Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation. (semanticscholar.org)
  • Econazole eases the symptoms of infections such as these by killing the fungi causing the infection. (patient.info)
  • Econazole, an imidazole derivative, is indicated in the treatment of skin infections such as dermatophytosis, superficial candidasis, and tinea versicolor, and of infections of the nails. (creative-peptides.com)
  • Econazole is effective in cutaneous infections. (medscape.com)
  • Econazole is an antifungal drug prescribed to treat skin infections such as tinea cruris (jock itch), tinea pedis (athlete's foot), tinea corporis (ringworm), tinea versicolor (a skin discoloration) and others. (helprx.info)
  • Econazole is an antifungal medicine used to treat infections with fungi and yeasts. (cysticacnecauses.net)
  • Econazole dermatophyte infections such as ringworm and athletes foot etc. (ringwormtreatmentsforhumans.com)
  • EcoNail is the company's patented lacquer which contains the antifungal econazole and MacroChem's enhancer SEPA. (thefreedictionary.com)
  • Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using econazole and each time you get a refill. (cysticacnecauses.net)
  • When given by mouth to pregnant animals in doses 10 to 40 times the amount normally applied to the skin, Econazole Nitrate was found to be toxic to the developing fetus. (azmedications.com)
  • Low doses of econazole inhibit both, TRPV6 dependent Ca(2+) signals and cell proliferation while BTP2, a potent inhibitor of Ca(2+) signals and cell proliferation in T-cells, neither influences TRPV6 dependent Ca(2+) signals nor cell proliferation of HEK-293 cells. (nih.gov)
  • Wash and dry the infected area of skin before you apply econazole. (patient.info)
  • Most cases reported product application with use under occlusion, genital application, or application to a large body surface area which may increase the systemic absorption of Econazole LP. Monitoring of International Normalized Ratio (INR) and/or prothrombin time may be indicated especially for patients who apply econazole to large body surface areas, in the genital area, or under occlusion. (sdrugs.com)
  • Econazole nitrate exhibits broad-spectrum antifungal activity against the following organisms in vitro , but the clinical significance of these data is unknown. (nih.gov)
  • Econazole (Eco), a potent broad-spectrum anti-fungal agent, has been used in the treatment of superficial mycosis. (elsevier.com)
  • tell your doctor and pharmacist if you are allergic to econazole or any other drugs. (medlineplus.gov)
  • In this study, we report the in vitro antileishmanial activity of the imidazole drugs clotrimazole, and for the first time in literature, econazole and bifonazole and their potential action to affect the regulation of reactive oxygen species (ROS) of the parasites. (moleculardevices.com)
  • Because many drugs are excreted in human milk, caution should be exercised when Econazole LP is administered to a nursing woman. (sdrugs.com)
  • To get a free discount card for econazole and most other prescription drugs, click 'Free Card' at the top of the page. (helprx.info)
  • Econazole is a medicine which is also used to treat vaginal thrush. (patient.info)
  • There is information about this in the separate medicine leaflet called Econazole for vaginal thrush . (patient.info)
  • Econazole is an antifungal medication of the imidazole class. (wikipedia.org)
  • Econazole nitrate exhibits strong anti-feeding properties against the keratin-digesting common clothes moth Tineola bisselliella. (wikipedia.org)
  • Econazole compromises the integrity of fungal cell wall through inhibiting 14-alpha demethylase, which catalyzes conversion of lanosterol to ergosterol, an essential component of the fungal cell wall. (creative-peptides.com)
  • Econazole disrupts fungal cell wall permeability, causing fungal cell death. (medscape.com)
  • Treatment of insect bites, econazole (Spectazole®)11 X X Tinea corporis (ringworm on the skin) refers to tinea anywhere on the body except the scalp, beard, feet, or hands. (ringwormtreatmentsforhumans.com)
  • After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. (nih.gov)
  • This study evaluated the preformulation transungual permeability of econazole nitrate and formulation development of a transungual topical patch utilizing penetration enhancers in combination with econazole nitrate to optimize the delivery and penetration through the nail . (temple.edu)
  • The authors wish to thank Gufic Biosciences Ltd., Navsari, Guj arat, India, for kindly providing the gift sample of the drug econazole nitrate. (thefreedictionary.com)
  • Do not use Econazole Nitrate if you have had an allergic reaction to it or any other ingredient in this product. (azmedications.com)
  • You should not use econazole topical if you are allergic to it. (cysticacnecauses.net)
  • It is a component of Pevisone, Ecoderm-TA and ECOSONE (econazole/triamcinolone). (wikipedia.org)
  • If you become pregnant while using econazole, call your doctor. (medlineplus.gov)
  • Clotrimazole, econazole and miconazole are effective in short courses of 3 - 14 days in the treatment of vaginal candidiasis. (ringwormtreatmentsforhumans.com)
  • Percutaneous delivery of econazole using microemulsion as vehicle: formulation, evaluation and vesicle-skin interaction. (semanticscholar.org)
  • Polymeric nanosponges as an alternative carrier for improved retention of econazole nitrate onto the skin through topical hydrogel formulation. (semanticscholar.org)
  • There were ten penetration enhancers being screened in this project according to the enhancement for saturation solubility , in vitro nail penetration and in vitro skin permeation and penetration of the antifungal drug econazole nitrate . (temple.edu)
  • 2013) . Thiourea (TU) improved the solubility and nail penetration of econazole nitrate . (temple.edu)
  • The main purpose of this study is to improve and boost the solubility of Econazole Nitrate in water using phospholipid and surfactants, until it becomes possible to evaluate the utility of a mixture design in order to determine the optimal composition of non-ionic surfactants and phospholipids needed to obtain a significant improvement in the solubility of Econazole Nitrate in water. (pharmascope.org)
  • Analysis of the design space showed that, the solubility of Econazole Nitrate is importantly affected by the concentration of surfactants. (pharmascope.org)
  • Econazole may cause side effects. (medlineplus.gov)
  • See the full econazole topical side effects document. (drugs.com)
  • Econazole has been linked to minor side effects, such as stinging, swelling, redness and flaking skin. (reference.com)
  • Econazole is unlikely to cause any serious side-effects. (patient.info)
  • What are the possible side effects of taking econazole? (helprx.info)
  • Some people have reported side effects after applying econazole. (helprx.info)
  • What are the side effects of Sebazole Shampoo (Econazole Nitrate/Sulphur as Sodium Thiosulphate/Sodium Salicylate/Chloroxylenol)? (4nrx-uk.md)
  • Very small amounts of Econazole Nitrate are absorbed into the bloodstream, but quite a bit of the drug penetrates to the middle and inner layers of the skin, where it can kill fungal organisms that may have penetrated to deeper layers. (azmedications.com)
  • Before using econazole, thoroughly clean and dry the affected area, then apply just enough of the medication to cover the site, gently massage it into the skin until it disappears. (helprx.info)
  • Sebazole Shampoo (Econazole Nitrate/Sulphur as Sodium Thiosulphate/Sodium Salicylate/Chloroxylenol) should not be applied to skin that is broken or severely damaged. (4nrx-uk.md)
  • It was selected as the nail permeation enhancer and skin penetration enhancer for econazole nitrate . (temple.edu)