A steroid hormone that regulates the processes of MOLTING or ecdysis in insects. Ecdysterone is the 20-hydroxylated ECDYSONE.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
Proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions.
Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.
Presence of warmth or heat or a temperature notably higher than an accustomed norm.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A sport in which weights are lifted competitively or as an exercise.
These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.
C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.
A synthetic hormone with anabolic and androgenic properties.
A synthetic steroid with anabolic properties that are more pronounced than its androgenic effects. It has little progestational activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1188)
Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.
A synthetic hormone with anabolic and androgenic properties. It is used mainly in the treatment of anemias. According to the Fourth Annual Report on Carcinogens (NTP 85-002), this compound may reasonably be anticipated to be a carcinogen. (From Merck Index, 11th ed)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.
A family of flowering plants in the order Caryophyllales, with about 60 genera and more than 800 species of plants, with a few shrubs, trees, and vines. The leaves usually have nonindented edges.
A plant genus of the family POACEAE that contains allergen Dac g I.
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Procedure in which an individual is induced into a trance-like state to relieve pain. This procedure is frequently performed with local but not general ANESTHESIA.
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)
Processes orchestrated or driven by a plethora of genes, plant hormones, and inherent biological timing mechanisms facilitated by secondary molecules, which result in the systematic transformation of plants and plant parts, from one stage of maturity to another.
The physiological processes, properties, and states characteristic of plants.
A measure of the amount of WATER VAPOR in the air.
Removal of moisture from a substance (chemical, food, tissue, etc.).
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The quality or state of being wettable or the degree to which something can be wet. This is also the ability of any solid surface to be wetted when in contact with a liquid whose surface tension is reduced so that the liquid spreads over the surface of the solid.
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
The relative amounts of various components in the body, such as percentage of body fat.
One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.
A neurosurgical procedure that removes or disconnects the epileptogenic CEREBRAL CORTEX of a hemisphere. Hemispherectomy is usually performed for patients with intractable unilateral EPILEPSY due to malformations of cortical development or brain lesions. Depending on the epileptogenic area in the hemisphere, cortical removal can be total or partial.
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
The time span between the beginning of physical activity by an individual and the termination because of exhaustion.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.

Inducible genetic suppression of neuronal excitability. (1/349)

Graded, reversible suppression of neuronal excitability represents a logical goal of therapy for epilepsy and intractable pain. To achieve such suppression, we have developed the means to transfer "electrical silencing" genes into neurons with sensitive control of transgene expression. An ecdysone-inducible promoter drives the expression of inwardly rectifying potassium channels in polycistronic adenoviral vectors. Infection of superior cervical ganglion neurons did not affect normal electrical activity but suppressed excitability after the induction of gene expression. These experiments demonstrate the feasibility of controlled ion channel expression after somatic gene transfer into neurons and serve as the prototype for a novel generalizable approach to modulate excitability.  (+info)

Depression of synaptic efficacy in high- and low-output Drosophila neuromuscular junctions by the molting hormone (20-HE). (2/349)

The molt-related steroid hormone, 20-hydroxyecdysone (20-HE), was applied to muscles 6 and 7 of third instar larval of Drosophila melanogaster neuromuscular junction preparations to examine if rapid, nongenomic responses could be observed as was shown recently to occur in crustacean neuromuscular junctions. At a dose of 10 microM, the excitatory junction potentials were reduced in amplitude within minutes. To elucidate the site of action of the hormone, focal-macropatch recordings of synaptic currents were obtained over the neuromuscular junctions. The results showed that the high-output (Is) and the low-output (Ib) motor nerve terminals, which innervate muscles 6 and 7, released fewer synaptic vesicles for each stimulation while exposed to 20-HE. Because the size and shape of synaptic currents from spontaneous releases did not change, the effects of the 20-HE are presynaptic. The rapid effects of this hormone may account in part for the quiescent behavior associated with molts among insects and crustaceans.  (+info)

Induction of Sarcophaga central nervous system remodeling by 20-hydroxyecdysone in vitro. (3/349)

Proliferation and apoptosis of neural cells were found to be induced simultaneously when larval brains of Sarcophaga peregrina were cultured in the presence of 20-hydroxyecdysone (20-HE) for 24 h. The locations of proliferating cells and apoptotic cells in the brain hemispheres were different. The morphology of brains exposed to 20-HE for a short period proceeded to change sequentially when culture was continued for 2 days even in the absence of 20-HE. These changes mainly consisted of enlargement of the brain hemispheres and extension of the interval between two hemispheres, which closely paralleled the morphological changes of brains that occur in the early pupal stage, suggesting that ecdysteroid alone is sufficient to induce the remodeling of the central nervous system of holometabolous insects. Synthesis of a protein with a molecular mass of 66 kDa was shown to be selectively repressed when brains were cultured in the presence of 20-HE.  (+info)

Transcript titers of ecdysteroid receptor components vary between tissues and stages during Drosophila development. (4/349)

In Drosophila, the ecdysteroids trigger the key regulatory cascades controlling the coordinated changes in the developmental pathway of molting and metamorphosis. Ecdysone action is mediated by a heterodimer consisting of the three ecdysone receptor (EcR) isoforms and the ultraspiracle proteins (USP). Heterodimers of these proteins bind to the ecdysone response element and ecdysone to modulate gene transcription. In this study, we developed a competitive reverse transcription polymerase chain reaction (RT-PCR) method to quantify the transcripts of functional ecdysone receptor components in individual tissues and for the whole body. The relatively small amount of variation in usp transcripts of the different tissues indicates that this gene does not perform a spatially restricted function in the late third instar wandering larvae while EcR isoforms were expressed in a more tissue-restricted pattern in the same stage. EcR-B1 was expressed at higher levels in larval tissues that are fated for histolysis, whereas EcR-A predominates in the imaginal discs. This result supports the hypothesis that a particular metamorphic response requires particular EcR isoforms. The transcript levels of the functional ecdysone receptor components fluctuate dramatically during development, suggesting that the regulations of the transcriptional and posttranscriptional levels of these genes play some role in ecdysteroid response during Drosophila development.  (+info)

Control of oocyte maturation in sexually mature Drosophila females. (5/349)

In many sexually mature insects egg production and oviposition are tightly coupled to copulation. Sex-Peptide is a 36-amino-acid peptide synthesized in the accessory glands of Drosophila melanogaster males and transferred to the female during copulation. Sex-Peptide stimulates vitellogenic oocyte progression through a putative control point at about stage 9 of oogenesis. Here we show that application of the juvenile hormone analogue methoprene mimics the Sex-Peptide-mediated stimulation of vitellogenic oocyte progression in sexually mature virgin females. Apoptosis is induced by 20-hydroxyecdysone in nurse cells of stage 9 egg chambers at physiological concentrations (10(-7) M). 20-Hydroxyecdysone thus acts as an antagonist of early vitellogenic oocyte development. Simultaneous application of juvenile hormone analogue, however, protects early vitellogenic oocytes from 20-hydroxyecdysone-induced resorption. These results suggest that the balance of these hormones in the hemolymph regulates whether oocytes will progress through the control point at stage 9 or undergo apoptosis. These data are further supported by a molecular analysis of the regulation of yolk protein synthesis and uptake into the ovary by the two hormones. We conclude that juvenile hormone is a downstream component in the Sex-Peptide response cascade and acts by stimulating vitellogenic oocyte progression and inhibiting apoptosis. Since juvenile hormone analogue does not elicit increased oviposition and reduced receptivity, Sex-Peptide must have an additional, separate effect on these two postmating responses.  (+info)

Impairment of the proapoptotic activity of Bax by missense mutations found in gastrointestinal cancers. (6/349)

We have reported previously that codon 169 of the proapoptotic gene BAX is a mutational hot spot in gastrointestinal cancer. Two different mutations were found in this codon, replacing the wild-type threonine by alanine or methionine. To compare the proapoptotic activity of these Bax mutants with wild-type Bax, we established an ecdysone (muristerone A)-inducible system in cultured human embryonal kidney 293 cells. Addition of muristerone A induced a dose-dependent decrease in the viability of cells transfected with wild-type BAX, but this loss of viability was inhibited in cells transfected with BAX mutants. Furthermore, muristerone A induced morphological changes characteristic of apoptosis, including cell shrinkage, rounding, formation of apoptotic bodies, detachment and nuclear condensation and fragmentation, in cells transfected with wild-type BAX. These hallmarks of apoptosis were clearly diminished in cells transfected with BAX mutants. Mutation of threonine 169 did not affect the binding of Bax to Bax, Bcl-2, or Bcl-X(L). These results demonstrate that missense mutations at codon 169 of BAX are functional because they inhibit its apoptotic activity. This is the first report of the functional significance of missense mutations in BAX, or any other proapoptotic member of the Bcl-2 family, in primary human tumors.  (+info)

The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription. (7/349)

p204, a member of the interferon-inducible p200 family of murine proteins, is primarily nucleolar. We generated cell lines in which p204 was inducible by muristerone. This induction resulted in retardation of cell proliferation and inhibition of rRNA transcription in vivo. Interferon treatment, resulting in p204 induction and retardation of proliferation, also caused inhibition of rRNA transcription in vivo. p204 also inhibited rRNA transcription in vitro. This inhibition was overcome by addition of UBF1, the rRNA-specific transcription factor. A direct interaction between p204 and UBF1 was revealed in vitro in pull-down assays, and in vivo by co-immunoprecipitation from cell extracts. UBF1 bound strongly to at least two regions of p204: the N-terminal segment linked to the conserved 200 amino acid a segment, and the conserved 200 amino acid b segment. Cleavage of the a or b segments into two segments (encoded by single exons) resulted in a strong decrease or loss of binding. The inhibition of rRNA transcription by p204 may be due to the inhibition by p204 of the specific DNA binding of UBF1. This was revealed in electrophoretic mobility shift, magnetic bead and footprinting assays. Thus, p204 serves as a mediator of the inhibition of rRNA transcription by interferon.  (+info)

Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 production. (8/349)

The Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) is a pleiotropic protein the activities of which include effects on gene expression and cell transformation, growth, and death. LMP1 has been shown to induce nuclear factor (NF)-kappaB and c-Jun NH2-terminal kinase/AP-1 activities in target cells, and in this study we demonstrate that LMP1 also engages the p38 mitogen-activated protein kinase cascade, leading to activation of the transcription factor ATF2. Mutational analysis of the LMP1 cytoplasmic COOH terminus revealed that p38 activation occurs from both the tumor necrosis factor receptor-associated factor (TRAF)-interacting, membrane-proximal COOH-terminal activating region (CTAR)1 domain (amino acids 186-231) and the extreme tumor necrosis factor receptor-associated death domain (TRADD) binding CTAR2 region (amino acids 351-386). Because LMP1 also engages signaling on the NF-kappaB axis through CTAR1 and CTAR2, we have examined whether these two pathways are overlapping or independent. We have found that inhibition of p38 by the highly specific inhibitor SB203580 did not affect NF-kappaB binding activity. Conversely, although the metabolic inhibitor D609 blocked NF-kappaB activation, it did not impair the ability of LMP1 to signal on the p38 axis, suggesting that these two LMP1-mediated pathways are primarily independent. Divergence of signals must, however, occur downstream of TRAF2 as a dominant negative TRAF2 mutant that blocks LMP1-induced NF-kappaB activation also inhibited p38 signaling. In addition, we have found that p38 inhibition significantly impaired LMP1-mediated interleukin-6 and -8 expression. Thus, p38 may play a significant cooperative role in regulating at least some of the pleiotropic activities of LMP1.  (+info)

Ecdysterone info, beta ecdysterone information, ecdysterone can be confusing to understand when one considers the way that it works naturally in insects, shell-fish and plants. It has been conclusively proven to have a positive effect on humans and is called bug-juice by bodybuilders for a good reason.
In this study the depressant effect of fractions from P. glomerata was initially evaluated using the mice barbiturate sleeping time test as reference. The fractions tested were the CHCl3, the EtOAc, the n-BuOH and the aqueous fraction obtained from P. glomerata subterraneous parts. Only the pretreatment with the lipophilic fraction (CHCl3: EtOAc, 1:1, w/w) increased the barbiturate sleeping time (i.p 500 mg/kg; v.o. 1000 mg/kg). Ecdysterone, the main substance isolated from this lipophilic fraction, was identifi ed by spectroscopic methods and its content in the ethanol extract was determined as 1.4% (w/w) by HPLC. In order to investigate the hypothesis of ecdysterone displaying a depressant effect on nervous central system, an evaluation toward the hypnotic-sedative and anxiolytic effects of this drug was carried out. Ecdysterone 100 mg/kg, i.p, increased the barbiturate sleeping time without provoking hypothermia; when administered by oral route its minimal effective dose was 400 mg/kg. On the ...
Ecdysterone clinical studies, ecdysterone studies show a rather dramatic increase in muscle mass in 12 weeks of 6% to 7% and a decrease in fat at the same time of 10%.
20-Hydroxyecdysone and other ecdysteroids are used in biochemistry research as inducers in transgenic animals, whereby a new gene is introduced into an animal so that its expression is under the control of an introduced ecdysone receptor. Adding or removing ecdysteroids from the animals diet then gives a convenient way to turn the inserted gene on or off (see ecdysone receptor). At usual doses, 20-hydroxyecdysone appears to have little or no effect on animals that do not have extra genes inserted; it also has high bioavailability when taken orally, so it is useful for determining whether the transgene has been taken up effectively.[4] For uses in gene therapy, it may be necessary to investigate more thoroughly the natural sources of ecdysteroids in humans (which appear to include dietary phytoecdysteroids, gut flora, helminth infections, and other diseases).[5] There is some in vitro evidence to show that 20-hydroxyecdysone has effects on some kinds of blood cells such as lymphocytes and ...
Read Ecdysone 20-monooxygenase activity in Drosophila virilis strains varying in ecdysteroid response to heat stress, Russian Journal of Genetics on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
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TY - CONF. T1 - Effects of methoxyisoflavone, ecdysterone, and sulfo-polysaccharide (CSP3) supplementation during training on body composition and training adaptations. AU - Wilborn, C.. AU - Campbell, B.. AU - Thomas, A.. AU - Slonaker, B.. AU - Vacanti, T.. AU - Marcello, B.. AU - Baer, J.. AU - Kerksick, C.. AU - Rasmussen, C.. AU - Greenwood, M.. AU - Ounpraseuth, S.. AU - Casey, P.. AU - Wilson, R.. AU - Kreider, R.. AU - Earnest, C.P.. PY - 2004. Y1 - 2004. UR - http://www.aspet.org/Page.aspx?id=425. M3 - Abstract. T2 - Experimental Biology, 2004. Y2 - 16 April 2004 through 21 April 2004. ER - ...
e-induced injury and repair of skeletal muscle: cellular and molecular...In addition to the formal sessions a large portion of the day is s......,Integrative,biology,of,exercise,APS,Intersociety,meeting,October,6-9,,2004,in,Austin,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
CAS#: 5289-74-7 MF: C27H44o7 MW: 480.63 Purity: 98%HPLC Package: 20mg-1g Storage: In sealed, cool and dry condition Category: Standard
This is one powerful muscle building supplement! Everyone keeps asking what the hot new supplement for the year is going to be. Well here is your answer! Introducing the Russian breakthrough in sports performance nutrition! Meet ECDY-BOLIN. Developed in Russia, TrulyHuge brings you this cutting edge dietary supplement. What is it? Ecdysterone: the technical name
Insect molting is initiated by interaction of the molting hormone (20-hydroxyecdysone: 20E) with the ecdysone receptor (EcR). Thus, compounds that modulate the 20E-EcR interaction are able to interrupt insect molting and therefore may have useful insecticidal activity. Diacylhydrazines (DAHs) have been found to disrupt the 20E-EcR interaction and five DAHs, including tebufenozide and chromafenozide, are currently in use as insecticides. Most of them are very toxic to Lepidoptera but inactive or very weakly active against other insect orders such as Diptera and Coleoptera. This order-specific toxicity of DAHs is caused by differences in their binding affinity to the EcRs in the different insect species. The three dimensional structures of the ligand binding domains (LBDs) of EcR of Heliothis virescens (HvEcR) complexed with ponasterone A (PonA) and 20E have been solved crystallographically. Furthermore, EcR bound to a DAH (BYI06830, a chromafenozide analog) has also been solved, and comparison of ...
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Cell invasion through a dense three-dimensional (3D) matrix is thought to depend in the power of cells to create traction forces. any risk of strain energy of extremely invasive MDA-MB-231 breasts carcinoma and A-125 lung carcinoma cells in collagen gels. The outcomes were set alongside the stress energy produced by noninvasive MCF-7 breasts and A-549 lung carcinoma Muristerone A cells. In every situations cells locally contracted the matrix. Invasive breast and lung carcinoma cells showed a significantly higher contractility compared to non-invasive cells. Higher contractility however was not universally associated with higher invasiveness. For instance non-invasive A-431 vulva carcinoma cells were the most contractile cells among all cell lines tested. As a universal feature however we found that invasive cells assumed an elongated spindle-like morphology as opposed to a more spherical shape of noninvasive cells. Accordingly the distribution of strain energy density around invasive cells ...
The insect ecdysteroid receptor consists of a heterodimer between EcR and the RXR-orthologue, USP. We addressed the question of whether this heterodimer, like all other RXR heterodimers, may be formed in the absence of ligand and whether ligand promotes dimerization. We found that C-terminal protein fragments that comprised the ligand binding, but not the DNA binding domain of EcR and USP and which were equipped with the activation or DNA binding region of GAL4, respectively, exhibit a weak ability to interact spontaneously with each other. ...
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CiteSeerX - Scientific documents that cite the following paper: A relational framework for abstract interpretation. LNCS 215:156-171
Pretty interesting! I liked the idea, but it would have been cool for their age to be displayed without having to mouse-over them, and also to be able to move them next to others for a greater chance at mating with them. Also I felt it was always random when I reached the goal. There should have been clearer methods of reaching the goal, other than to just wait for the goal product to randomly spawn. (Of course it isnt technically random, due to the sliders and such, but it still felt too random and uncontrolled). But yeah, other than those, this was a brilliant idea. ...
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If one looks at the structure of these steroids we can deduce their benefits. It appears that all 6-Keto anabolics work by increasing both protein synthesis (suggested via messenger RNA) and myotubule increases (the creation of new muscle cells) and the only thing that separates them is their ability to be metabolically cleared in the body.. In order of excretion (rendering the steroids inactive) would come at the expense of their hydroxyl groups and skeleton modifications. Hydroxyl groups are ripe pickings for sulfotransferase, which makes sulfated forms of these steroids. Sulfated steroids are what is commonly excreted in the urine as the body processes steroids, so the more resistant the steroid to sulfation the greater the activity.. Based on structure from worst to best here is the list of metabolic resistance (more activity). Turkesterone - this appears to have more metabolic activity than standard ecdysterone, but also shares the same metabolic fate of this steroid since it contains ...
How does it work?. Ecdisten has been tested for its effects on work capacity, immune function, lean body mass and fat loss in a number of scientific studies. The vast majority of research indicates an increase in lean mass, when combined with resistance training. Results were further improved when Ecdisten was consumed with protein.. What results can I expect?. Expect to see faster gains in muscle size, with greater recovery between workouts. Several Russian scientists testing Ecdysterone also report that subjects experienced less fatigue, more motivation, and improved strength.. What can it be combined with?. Because of its positive effects on protein synthesis, Ecdisten should be combined with extra protein. Some experts believe that Ecdisten has a synergistic effect with Tribulus Terrestris. Synergy means that the combination of two or more nutrients may yield better results than any one of those nutrients by itself. However, double-blind placebo controlled studies of this combination have ...
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Ecdysteroids are a class of hormones that are the androgens of insects; they are involved with reproduction and molting, but human ingestion might be healthy or increase muscle mass. Human interventions are lacking and problems with ecdysteroid ingestion exist.
In 1974, Ashburner and colleagues postulated a model to explain the control of the puffing sequence on Drosophila polytene chromosomes initiated by the molting hormone 20-hydroxyecdysone. This model inspired a generation of molecular biologists to clone and characterize elements of the model, thereb …
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TY - JOUR. T1 - Regulation of the transcription factor E75 by 20-hydroxyecdysone and juvenile hormone in the epidermis of the tobacco hornworm, Manduca sexta, during larval molting and metamorphosis. AU - Zhou, Baohua. AU - Hiruma, Kiyoshi. AU - Jindra, Marek. AU - Shinoda, Tetsuro. AU - Segraves, William A.. AU - Malone, Fae. AU - Riddiford, Lynn M.. PY - 1998/1/15. Y1 - 1998/1/15. N2 - The homolog of the ecdysteroid-induced transcription factor E75A in Drosophila melanogaster was cloned from the tobacco hornworm, Manduca sexta, and its developmental expression and hormonal regulation were analyzed. Both E75A and E75B mRNAs were found in the abdominal epidermis during both the larval and the pupal molts, with E75A appearing before E75B, coincident with the rise of ecdysteroid. Exposure of either fourth or fifth instar epidermis to 20E in vitro caused the rapid, transient induction of E75A RNA with a peak at 6 and 3 h, respectively, followed by maintenance at low levels until 24 h. Epidermis ...
Olfactory information mediating sexual behavior is crucial for reproduction in many animals, including insects. In male moths, the macroglomerular complex of the primary olfactory center, the antennal lobe (AL) is specialized in the treatment of information on the female-emitted sex pheromone. Evidence is accumulating that modulation of behavioral pheromone responses occurs through neuronal plasticity via the action of hormones and/or catecholamines. We recently showed that a G-protein-coupled receptor (GPCR), AipsDopEcR, with its homologue known in Drosophila for its double affinity to the main insect steroid hormone 20-hydroxyecdysone (20E), and dopamine (DA), present in the ALs, is involved in the behavioral response to pheromone in the moth, Agrotis ipsilon. Here we tested the role of AipsDopEcR as compared to nuclear 20E receptors in central pheromone processing combining receptor inhibition with intracellular recordings of AL neurons. We show that the sensitivity of AL neurons for the pheromone in
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TY - JOUR. T1 - Drosophila metamorphosis. T2 - The only way is USP?. AU - Buszczak, Michael. AU - Segraves, William A.. PY - 1998/12/3. Y1 - 1998/12/3. N2 - The steroid insect molting hormone 20-hydroxyecdysone is believed to control critical aspects of development and reproduction through a heterodimeric receptor comprising the Ecdysone Receptor and the Ultraspiracle proteins. Recent findings suggest that other hormones and receptors might also be involved.. AB - The steroid insect molting hormone 20-hydroxyecdysone is believed to control critical aspects of development and reproduction through a heterodimeric receptor comprising the Ecdysone Receptor and the Ultraspiracle proteins. Recent findings suggest that other hormones and receptors might also be involved.. UR - http://www.scopus.com/inward/record.url?scp=0032481121&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0032481121&partnerID=8YFLogxK. M3 - Article. C2 - 9843674. AN - SCOPUS:0032481121. VL - 8. SP - ...
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The polyhydroxylated derivatives of 7-dehydro, 6-ketocholesterol (Ecdysone, Ecdysteroids, Ecd) were accidentally discovered in the search for an insect moulting hormone in 1965. The first Ecd compound, named ecdysone (ecdysis = shedding off the cuticle), was isolated from silkworm pupae.
Pulses of the steroid hormone 20-hydroxyecdysone (20E) trigger the larval-to-adult metamorphosis of Drosophila by reprogramming gene expression throughout the organism. 20E directly induces a small set of early regulatory genes that repress their own expression and induce a large set of late seconda …
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... (ecdysterone or 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and ... July 2019). "Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans ... July 2019). "Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans ... ecdysterone, and sulfo-polysaccharide supplementation on training adaptations in resistance-trained males". Journal of the ...
The root contains phytochemicals including saponins (pfaffosides), pfaffic acid, beta-ecdysterone, glycosides, and ...
Ecdysterone, an insect moulting hormone, and long chain alcohols are also found in Achyranthes aspera. BSBI List 2007 (xls). ...
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Gao XY, Wang DW, Li FM (2000). "Determination of ecdysterone in Achyranthes bidentata Bl and its activity promoting ...
Animal steroids include compounds of vertebrate and insect origin, the latter including ecdysteroids such as ecdysterone ( ...
... ecdysterone MeSH D06.472.445.573.666 - juvenile hormones MeSH D06.472.445.573.666.170 - diflubenzuron MeSH D06.472.445.573. ...
The skeleton is rich in histidine and contains the unusual ecdysterone, ajugasterone-C. The growth rate of the colony is slow ...
... ecdysterone MeSH D04.808.247.222.265.450 - ketocholesterols MeSH D04.808.247.222.284 - cholesterol MeSH D04.808.247.222.284.070 ...
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CAS#: 5289-74-7
MF: C27H44o7
MW: 480.63
Purity: 98%HPLC
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  • 20-Hydroxyecdysone ( ecdysterone or 20E ) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods . (wikipedia.org)
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  • Their recommendation was based on a 10-week study of 46 men, who were given either a placebo or a daily supplement containing ecdysterone [ 5 ]. (muscleevo.net)
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  • Chermnykh NS, Shimanovskii NL, Shutko GV, Syrov VN (1988) The action of methandrostenolone and ecdysterone on the physical endurance of animals and on protein metabolism in the skeletal muscles. (springer.com)
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