Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.
A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.
A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.
Two or more vaccines in a single dosage form.
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.

Chimpanzee adenovirus vaccine protects against Zaire Ebola virus. (1/60)

This study evaluated the use of a chimpanzee-based adenovirus vaccine in mouse and Guinea pigs models of Zaire Ebola virus (ZEBOV) infection. Vaccine vector expressing the envelope glycoprotein of ZEBOV was created from the molecular clone of chimpanzee adenovirus pan7 (AdC7). AdC7 vaccine stimulated robust T and B cell responses to ZEBOV in naive mice inducing complete protection to an otherwise lethal challenge of ZEBOV. Complete protection to Zaire Ebola virus was also observed in Guinea pigs vaccinated with a relatively low dose of AdC7 (5 x 10(9)/kg). Pre-existing immunity to AdHu5 was generated in mice following pre-exposure to AdHu5 or administration of pooled human immune globulin. Pre-existing immunity to human adenoviruses severely compromised the efficacy of the human AdHu5 vaccine but not the chimpanzee AdC7 vaccine. These results validate further development of Chimpanzee-based vaccine and highlight the impact of pre-existing immunity to the vaccine carrier.  (+info)

A single intranasal inoculation with a paramyxovirus-vectored vaccine protects guinea pigs against a lethal-dose Ebola virus challenge. (2/60)

To determine whether intranasal inoculation with a paramyxovirus-vectored vaccine can induce protective immunity against Ebola virus (EV), recombinant human parainfluenza virus type 3 (HPIV3) was modified to express either the EV structural glycoprotein (GP) by itself (HPIV3/EboGP) or together with the EV nucleoprotein (NP) (HPIV3/EboGP-NP). Expression of EV GP by these recombinant viruses resulted in its efficient incorporation into virus particles and increased cytopathic effect in Vero cells. HPIV3/EboGP was 100-fold more efficiently neutralized by antibodies to EV than by antibodies to HPIV3. Guinea pigs infected with a single intranasal inoculation of 10(5.3) PFU of HPIV3/EboGP or HPIV3/EboGP-NP showed no apparent signs of disease yet developed a strong humoral response specific to the EV proteins. When these animals were challenged with an intraperitoneal injection of 10(3) PFU of EV, there were no outward signs of disease, no viremia or detectable EV antigen in the blood, and no evidence of infection in the spleen, liver, and lungs. In contrast, all of the control animals died or developed severe EV disease following challenge. The highly effective immunity achieved with a single vaccine dose suggests that intranasal immunization with live vectored vaccines based on recombinant respiratory viruses may be an advantageous approach to inducing protective responses against severe systemic infections, such as those caused by hemorrhagic fever agents.  (+info)

Development of a cAdVax-based bivalent ebola virus vaccine that induces immune responses against both the Sudan and Zaire species of Ebola virus. (3/60)

Ebola virus (EBOV) causes a severe hemorrhagic fever for which there are currently no vaccines or effective treatments. While lethal human outbreaks have so far been restricted to sub-Saharan Africa, the potential exploitation of EBOV as a biological weapon cannot be ignored. Two species of EBOV, Sudan ebolavirus (SEBOV) and Zaire ebolavirus (ZEBOV), have been responsible for all of the deadly human outbreaks resulting from this virus. Therefore, it is important to develop a vaccine that can prevent infection by both lethal species. Here, we describe the bivalent cAdVaxE(GPs/z) vaccine, which includes the SEBOV glycoprotein (GP) and ZEBOV GP genes together in a single complex adenovirus-based vaccine (cAdVax) vector. Vaccination of mice with the bivalent cAdVaxE(GPs/z) vaccine led to efficient induction of EBOV-specific antibody and cell-mediated immune responses to both species of EBOV. In addition, the cAdVax technology demonstrated induction of a 100% protective immune response in mice, as all vaccinated C57BL/6 and BALB/c mice survived challenge with a lethal dose of ZEBOV (30,000 times the 50% lethal dose). This study demonstrates the potential efficacy of a bivalent EBOV vaccine based on a cAdVax vaccine vector design.  (+info)

Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs. (4/60)

BACKGROUND: Ebola virus causes a hemorrhagic fever syndrome that is associated with high mortality in humans. In the absence of effective therapies for Ebola virus infection, the development of a vaccine becomes an important strategy to contain outbreaks. Immunization with DNA and/or replication-defective adenoviral vectors (rAd) encoding the Ebola glycoprotein (GP) and nucleoprotein (NP) has been previously shown to confer specific protective immunity in nonhuman primates. GP can exert cytopathic effects on transfected cells in vitro, and multiple GP forms have been identified in nature, raising the question of which would be optimal for a human vaccine. METHODS AND FINDINGS: To address this question, we have explored the efficacy of mutant GPs from multiple Ebola virus strains with reduced in vitro cytopathicity and analyzed their protective effects in the primate challenge model, with or without NP. Deletion of the GP transmembrane domain eliminated in vitro cytopathicity but reduced its protective efficacy by at least one order of magnitude. In contrast, a point mutation was identified that abolished this cytopathicity but retained immunogenicity and conferred immune protection in the absence of NP. The minimal effective rAd dose was established at 10(10) particles, two logs lower than that used previously. CONCLUSIONS: Expression of specific GPs alone vectored by rAd are sufficient to confer protection against lethal challenge in a relevant nonhuman primate model. Elimination of NP from the vaccine and dose reductions to 10(10) rAd particles do not diminish protection and simplify the vaccine, providing the basis for selection of a human vaccine candidate.  (+info)

Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replication. (5/60)

The VP35 protein of Zaire Ebola virus is an essential component of the viral RNA polymerase complex and also functions to antagonize the cellular type I interferon (IFN) response by blocking activation of the transcription factor IRF-3. We previously mapped the IRF-3 inhibitory domain within the C terminus of VP35. In the present study, we show that mutations that disrupt the IRF-3 inhibitory function of VP35 do not disrupt viral transcription/replication, suggesting that the two functions of VP35 are separable. Second, using reverse genetics, we successfully recovered recombinant Ebola viruses containing mutations within the IRF-3 inhibitory domain. Importantly, we show that the recombinant viruses were attenuated for growth in cell culture and that they activated IRF-3 and IRF-3-inducible gene expression at levels higher than that for Ebola virus containing wild-type VP35. In the context of Ebola virus pathogenesis, VP35 may function to limit early IFN-beta production and other antiviral signals generated from cells at the primary site of infection, thereby slowing down the host's ability to curb virus replication and induce adaptive immunity.  (+info)

Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges. (6/60)

The Marburg virus (MARV), an African filovirus closely related to the Ebola virus, causes a deadly hemorrhagic fever in humans, with up to 90% mortality. Currently, treatment of disease is only supportive, and no vaccines are available to prevent spread of MARV infections. In order to address this need, we have developed and characterized a novel recombinant vaccine that utilizes a single complex adenovirus-vectored vaccine (cAdVax) to overexpress a MARV glycoprotein (GP) fusion protein derived from the Musoke and Ci67 strains of MARV. Vaccination with the cAdVaxM(fus) vaccine led to efficient production of MARV-specific antibodies in both mice and guinea pigs. Significantly, guinea pigs vaccinated with at least 5 x 10(7) pfu of cAdVaxM(fus) vaccine were 100% protected against lethal challenges by the Musoke, Ci67 and Ravn strains of MARV, making it a vaccine with trivalent protective efficacy. Therefore, the cAdVaxM(fus) vaccine serves as a promising vaccine candidate to prevent and contain multi-strain infections by MARV.  (+info)

Generation of an adenoviral vaccine vector based on simian adenovirus 21. (7/60)

Adenoviral vectors can be used to generate potent humoral and cellular immune responses to transgene products. Use of adenoviral vectors based on non-human isolates may allow for their utilization in populations harbouring neutralizing antibodies to common human serotypes. A vector chimera was constructed using simian adenovirus 22 (a serotype belonging to the species Human adenovirus E) and simian adenovirus 21 (a serotype belonging to the species Human adenovirus B) expressing the Ebola (Zaire) virus glycoprotein (Ad C5/C1-ZGP). This chimeric adenovirus vector was used as a model to test its efficacy as a genetic vaccine and comparisons were made to a vector based on the commonly used human adenovirus C serotype 5 (Adhu5-ZGP). Ebola glycoprotein-specific T- and B-cell responses were measured in B10BR mice vaccinated with either Adhu5-ZGP or Ad C5/C1-ZGP vectors. Both vectors resulted in Ebola glycoprotein-specific gamma interferon-expressing T cells, although the Ad C5/C1-ZGP vector appeared to induce lower frequencies with kinetics slower than those elicited by the Adhu5-ZGP vector. The total immunoglobulin G response to Ebola glycoprotein was similar in sera from mice vaccinated with either vector. Two rhesus macaques vaccinated with the Ad C5/C1-ZGP vector were found to mount T-cell and antibody responses to the Ebola glycoprotein. It was found that a single administration of the chimeric Ad C5/C1-ZGP vector protected mice against a lethal challenge with a mouse-adapted strain of the Ebola (Zaire) virus.  (+info)

A DNA vaccine for Ebola virus is safe and immunogenic in a phase I clinical trial. (8/60)

Ebola viruses represent a class of filoviruses that causes severe hemorrhagic fever with high mortality. Recognized first in 1976 in the Democratic Republic of Congo, outbreaks continue to occur in equatorial Africa. A safe and effective Ebola virus vaccine is needed because of its continued emergence and its potential for use for biodefense. We report the safety and immunogenicity of an Ebola virus vaccine in its first phase I human study. A three-plasmid DNA vaccine encoding the envelope glycoproteins (GP) from the Zaire and Sudan/Gulu species as well as the nucleoprotein was evaluated in a randomized, placebo-controlled, double-blinded, dose escalation study. Healthy adults, ages 18 to 44 years, were randomized to receive three injections of vaccine at 2 mg (n = 5), 4 mg (n = 8), or 8 mg (n = 8) or placebo (n = 6). Immunogenicity was assessed by enzyme-linked immunosorbent assay (ELISA), immunoprecipitation-Western blotting, intracellular cytokine staining (ICS), and enzyme-linked immunospot assay. The vaccine was well-tolerated, with no significant adverse events or coagulation abnormalities. Specific antibody responses to at least one of the three antigens encoded by the vaccine as assessed by ELISA and CD4(+) T-cell GP-specific responses as assessed by ICS were detected in 20/20 vaccinees. CD8(+) T-cell GP-specific responses were detected by ICS assay in 6/20 vaccinees. This Ebola virus DNA vaccine was safe and immunogenic in humans. Further assessment of the DNA platform alone and in combination with replication-defective adenoviral vector vaccines, in concert with challenge and immune data from nonhuman primates, will facilitate evaluation and potential licensure of an Ebola virus vaccine under the Animal Rule.  (+info)

Ebola vaccines are medical products designed to confer immunity against the Ebola virus, a deadly pathogen that causes hemorrhagic fever. Several Ebola vaccine candidates have been developed and tested in clinical trials, with some showing promising results. The most advanced Ebola vaccine is rVSV-ZEBOV, which has been shown to be highly effective in preventing the disease in clinical trials. It uses a weakened version of the vesicular stomatitis virus (VSV) to deliver a protein from the Ebola virus surface, triggering an immune response that protects against infection. Other Ebola vaccine candidates use different approaches, such as delivering Ebola virus genes using a harmless adenovirus vector or using inactivated whole Ebola viruses. These vaccines are still in development and have not yet been approved for widespread use.

Ebola Hemorrhagic Fever (EHF) is a severe, often fatal illness in humans. It is one of the five identified subtypes of the Ebolavirus. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission.

The early symptoms include sudden onset of fever, fatigue, muscle pain, headache and sore throat. This is followed by vomiting, diarrhea, rash, symptoms of impaired kidney and liver function, and in some cases, both internal and external bleeding.

Laboratory findings include low white blood cell and platelet counts and elevated liver enzymes.

The virus is introduced into the human population through close contact with the blood, secretions, organs or other bodily fluids of infected animals such as fruit bats, porcupines and non-human primates. Then it spreads in communities through human-to-human transmission via direct contact (through broken skin or mucous membranes) with the blood, secretions, organs or other bodily fluids of infected people, and with surfaces and materials contaminated with these fluids.

Healthcare workers have frequently been infected while treating patients with suspected or confirmed EVD due to a lack of adequate infection prevention and control measures.

There are currently no approved specific antiviral drugs or vaccines for Ebola. Several promising treatments and vaccine candidates are being evaluated.

Ebolavirus is a genus of viruses in the family Filoviridae, order Mononegavirales. It is named after the Ebola River in the Democratic Republic of Congo (formerly Zaire), where the virus was first identified in 1976. There are six species of Ebolavirus, four of which are known to cause disease in humans: Zaire ebolavirus, Sudan ebolavirus, Bundibugyo ebolavirus, and Tai Forest ebolavirus (formerly Cote d'Ivoire ebolavirus). The fifth species, Reston ebolavirus, is known to cause disease in non-human primates and pigs, but not in humans. The sixth and most recently identified species, Bombali ebolavirus, has not been associated with any human or animal diseases.

Ebolaviruses are enveloped, negative-sense, single-stranded RNA viruses that cause a severe and often fatal hemorrhagic fever in humans and non-human primates. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. Fruit bats of the Pteropodidae family are considered to be the natural host of Ebolavirus.

The symptoms of Ebolavirus disease (EVD) typically include fever, severe headache, muscle pain, weakness, fatigue, and sore throat, followed by vomiting, diarrhea, rash, impaired kidney and liver function, and in some cases, both internal and external bleeding. The case fatality rate of EVD is variable but has been historically high, ranging from 25% to 90% in past outbreaks depending on the species and the quality of medical care. There are no licensed specific treatments or vaccines available for EVD, although several promising candidates are currently under development.

A vaccine is a biological preparation that provides active acquired immunity to a particular infectious disease. It typically contains an agent that resembles the disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and "remember" it, so that the immune system can more easily recognize and destroy any of these microorganisms that it encounters in the future.

Vaccines can be prophylactic (to prevent or ameliorate the effects of a future infection by a natural or "wild" pathogen), or therapeutic (to fight disease that is already present). The administration of vaccines is called vaccination. Vaccinations are generally administered through needle injections, but can also be administered by mouth or sprayed into the nose.

The term "vaccine" comes from Edward Jenner's 1796 use of cowpox to create immunity to smallpox. The first successful vaccine was developed in 1796 by Edward Jenner, who showed that milkmaids who had contracted cowpox did not get smallpox. He reasoned that exposure to cowpox protected against smallpox and tested his theory by injecting a boy with pus from a cowpox sore and then exposing him to smallpox, which the boy did not contract. The word "vaccine" is derived from Variolae vaccinae (smallpox of the cow), the term devised by Jenner to denote cowpox. He used it in 1798 during a conversation with a fellow physician and later in the title of his 1801 Inquiry.

Inactivated vaccines, also known as killed or non-live vaccines, are created by using a version of the virus or bacteria that has been grown in a laboratory and then killed or inactivated with chemicals, heat, or radiation. This process renders the organism unable to cause disease, but still capable of stimulating an immune response when introduced into the body.

Inactivated vaccines are generally considered safer than live attenuated vaccines since they cannot revert back to a virulent form and cause illness. However, they may require multiple doses or booster shots to maintain immunity because the immune response generated by inactivated vaccines is not as robust as that produced by live vaccines. Examples of inactivated vaccines include those for hepatitis A, rabies, and influenza (inactivated flu vaccine).

A viral vaccine is a biological preparation that introduces your body to a specific virus in a way that helps your immune system build up protection against the virus without causing the illness. Viral vaccines can be made from weakened or inactivated forms of the virus, or parts of the virus such as proteins or sugars. Once introduced to the body, the immune system recognizes the virus as foreign and produces an immune response, including the production of antibodies. These antibodies remain in the body and provide immunity against future infection with that specific virus.

Viral vaccines are important tools for preventing infectious diseases caused by viruses, such as influenza, measles, mumps, rubella, polio, hepatitis A and B, rabies, rotavirus, chickenpox, shingles, and some types of cancer. Vaccination programs have led to the control or elimination of many infectious diseases that were once common.

It's important to note that viral vaccines are not effective against bacterial infections, and separate vaccines must be developed for each type of virus. Additionally, because viruses can mutate over time, it is necessary to update some viral vaccines periodically to ensure continued protection.

I could not find a specific medical definition for "Vaccines, DNA." However, I can provide you with some information about DNA vaccines.

DNA vaccines are a type of vaccine that uses genetically engineered DNA to stimulate an immune response in the body. They work by introducing a small piece of DNA into the body that contains the genetic code for a specific antigen (a substance that triggers an immune response). The cells of the body then use this DNA to produce the antigen, which prompts the immune system to recognize and attack it.

DNA vaccines have several advantages over traditional vaccines. They are relatively easy to produce, can be stored at room temperature, and can be designed to protect against a wide range of diseases. Additionally, because they use DNA to stimulate an immune response, DNA vaccines do not require the growth and culture of viruses or bacteria, which can make them safer than traditional vaccines.

DNA vaccines are still in the experimental stages, and more research is needed to determine their safety and effectiveness. However, they have shown promise in animal studies and are being investigated as a potential tool for preventing a variety of infectious diseases, including influenza, HIV, and cancer.

Synthetic vaccines are artificially produced, designed to stimulate an immune response and provide protection against specific diseases. Unlike traditional vaccines that are derived from weakened or killed pathogens, synthetic vaccines are created using synthetic components, such as synthesized viral proteins, DNA, or RNA. These components mimic the disease-causing agent and trigger an immune response without causing the actual disease. The use of synthetic vaccines offers advantages in terms of safety, consistency, and scalability in production, making them valuable tools for preventing infectious diseases.

Combined vaccines are defined in medical terms as vaccines that contain two or more antigens from different diseases, which are given to provide protection against multiple diseases at the same time. This approach reduces the number of injections required and simplifies the immunization schedule, especially during early childhood. Examples of combined vaccines include:

1. DTaP-Hib-IPV (e.g., Pentacel): A vaccine that combines diphtheria, tetanus, pertussis (whooping cough), Haemophilus influenzae type b (Hib) disease, and poliovirus components in one injection to protect against these five diseases.
2. MMRV (e.g., ProQuad): A vaccine that combines measles, mumps, rubella, and varicella (chickenpox) antigens in a single injection to provide immunity against all four diseases.
3. HepA-HepB (e.g., Twinrix): A vaccine that combines hepatitis A and hepatitis B antigens in one injection, providing protection against both types of hepatitis.
4. MenACWY-TT (e.g., MenQuadfi): A vaccine that combines four serogroups of meningococcal bacteria (A, C, W, Y) with tetanus toxoid as a carrier protein in one injection for the prevention of invasive meningococcal disease caused by these serogroups.
5. PCV13-PPSV23 (e.g., Vaxneuvance): A vaccine that combines 13 pneumococcal serotypes with PPSV23, providing protection against a broader range of pneumococcal diseases in adults aged 18 years and older.

Combined vaccines have been thoroughly tested for safety and efficacy to ensure they provide a strong immune response and an acceptable safety profile. They are essential tools in preventing various infectious diseases and improving overall public health.

Bacterial vaccines are types of vaccines that are created using bacteria or parts of bacteria as the immunogen, which is the substance that triggers an immune response in the body. The purpose of a bacterial vaccine is to stimulate the immune system to develop protection against specific bacterial infections.

There are several types of bacterial vaccines, including:

1. Inactivated or killed whole-cell vaccines: These vaccines contain entire bacteria that have been killed or inactivated through various methods, such as heat or chemicals. The bacteria can no longer cause disease, but they still retain the ability to stimulate an immune response.
2. Subunit, protein, or polysaccharide vaccines: These vaccines use specific components of the bacterium, such as proteins or polysaccharides, that are known to trigger an immune response. By using only these components, the vaccine can avoid using the entire bacterium, which may reduce the risk of adverse reactions.
3. Live attenuated vaccines: These vaccines contain live bacteria that have been weakened or attenuated so that they cannot cause disease but still retain the ability to stimulate an immune response. This type of vaccine can provide long-lasting immunity, but it may not be suitable for people with weakened immune systems.

Bacterial vaccines are essential tools in preventing and controlling bacterial infections, reducing the burden of diseases such as tuberculosis, pneumococcal disease, meningococcal disease, and Haemophilus influenzae type b (Hib) disease. They work by exposing the immune system to a harmless form of the bacteria or its components, which triggers the production of antibodies and memory cells that can recognize and fight off future infections with that same bacterium.

It's important to note that while vaccines are generally safe and effective, they may cause mild side effects such as pain, redness, or swelling at the injection site, fever, or fatigue. Serious side effects are rare but can occur, so it's essential to consult with a healthcare provider before receiving any vaccine.

An AIDS vaccine is a type of preventive vaccine that aims to stimulate the immune system to produce an effective response against the human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS). The goal of an AIDS vaccine is to induce the production of immune cells and proteins that can recognize and eliminate HIV-infected cells, thereby preventing the establishment of a persistent infection.

Despite decades of research, there is still no licensed AIDS vaccine available. This is due in part to the unique challenges posed by HIV, which has a high mutation rate and can rapidly evolve to evade the immune system's defenses. However, several promising vaccine candidates are currently being tested in clinical trials around the world, and researchers continue to explore new approaches and strategies for developing an effective AIDS vaccine.

Ebola vaccines are vaccines either approved or in development to prevent Ebola. As of 2022, there are only vaccines against the ... "Ebola Vaccine Information Statement". U.S. Centers for Disease Control and Prevention (CDC). June 2022. Ebola Vaccines at the U ... Scholia has a topic profile for Ebola vaccine. "Ebola Vaccines". Drug Information Portal. U.S. National Library of Medicine. " ... The Wellcome Trust-CIDRAP Ebola Vaccine Team B (January 2017). Completing the development of Ebola vaccines: current status, ...
An Ebola vaccine was approved by the US FDA in December 2019. While there is no approved treatment for Ebola as of 2019[update ... "Ebola virus disease: Vaccines". www.who.int. Retrieved 29 March 2023. "Ebola Hemorrhagic Fever Prevention". Centers for Disease ... Ebola, also known as Ebola virus disease (EVD) and Ebola hemorrhagic fever (EHF), is a viral hemorrhagic fever in humans and ... "Ebola virus disease Information for Clinicians in U.S. Healthcare Settings , For Clinicians , Ebola (Ebola Virus Disease) , ...
... expressing Ebola envelope glycoprotein. The vaccine is targeted against the Makona variant of Ebola that was circulating in ... and Ad5-vectored Ebola vaccine. There is also a version called GamEvac which is a homologous Ad5-vectored vaccine. GamEvac- ... "Update with the development of Ebola vaccines and implications of emerging evidence to inform future policy recommendations" ( ... and Ad5-vectored Ebola vaccine: An open phase I/II trial in healthy adults in Russia". Hum Vaccin Immunother. 13 (3): 613-620. ...
... also known as Ebola Zaire vaccine live and sold under the brand name Ervebo, is an Ebola vaccine for adults that prevents Ebola ... Study confirms efficacy of NewLink Genetics ebola vaccine "Scientists hail '100% effective' Ebola vaccine". National Health ... August 2015). "EBOLA VACCINE. VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain ... Scholia has a topic profile for RVSV-ZEBOV vaccine. Ebola Vaccines at the U.S. National Library of Medicine Medical Subject ...
... typhoid vaccines and, more recently, new vaccines against Ebola. OVG is a research group within the Department of Paediatrics ... Vaccine Knowledge homepage. Retrieved 25 June 2015 NHS Choices page on the MenC vaccine with external link to Vaccine Knowledge ... 2014-15: a phase 1 study into a new vaccine against Ebola. In January 2015 this trial was commended in the House of Commons by ... "Oxford University doctors and scientists start trials for new Ebola vaccine". ITV News. 6 January 2015. Retrieved 25 June 2015 ...
The FDA subsequently approved the device for testing in up to 20 infected Ebola cases in the United States. Ebola vaccine Ebola ... Roberts D. "Ebola CDC director warns Ebola like 'forest fire' as Congress readies for hearing - Ebola crisis live updates". The ... Briggs H (7 August 2014). "Ebola: Experimental drugs and vaccines". BBC News Online. Retrieved 1 August 2014. Park A (19 ... 2018). "Advances in Designing and Developing Vaccines, Drugs, and Therapies to Counter Ebola Virus". Frontiers in Immunology. 9 ...
Gallagher, James (24 October 2014). "'Millions of Ebola vaccines' in 2015". BBC News. "The Alliance for Accelerating Excellence ... She worked on the Global Health Trials Initiative, DELTAS Africa programme, and on the Ebola Research Funding Initiative. In ... Tufet was involved with the Ebola research response. As part of this work, she oversaw the Kenya Medical Research Institute ( ...
In December 2019, the first Ebola vaccine was approved. rVSV-ZEBOV, otherwise known as Ervebo, is a vaccine for adults that ... Ebola virus epidemic in Guinea Ebola virus epidemic in Liberia Ebola virus epidemic in Nigeria Ebola virus epidemic in Sierra ... "Americans 'can't give in to hysteria or fear' over Ebola: Obama". Reuters. October 18, 2014. "WHO: Millions of Ebola Vaccine ... Ebola: How it spreads What gear to wear for protection from Ebola infection Ebola Hemorrhagic Fever - CDC.gov Portals: United ...
". "Vaccines: Calling the Shots web page". "Mass Extinction: Life at the Brink web page". "Spillover -- Zika, Ebola & Beyond ... Laura Helft, Emily Willingham (5 September 2014). "The Autism-Vaccine Myth". PBS. Retrieved 2 July 2019. "Your Inner Fish web ...
Tangwa, Godfrey B.; Browne, Katharine; Schroeder, Doris (2017-12-05). "Ebola Vaccine Trials". SpringerBriefs in Research and ... Ebola virus research undertaken in a resource-poor setting that had no incidence of Ebola, and amongst vulnerable populations ... when Indonesians were unlikely to benefit from the resulting vaccines. Imposing burdens and risks on research participants who ...
As of April 2021[update], six viral vector vaccines, four COVID-19 vaccines and two Ebola vaccines, have been authorized for ... The rVSV-ZEBOV vaccine, known as Ervebo, was approved as a prophylactic Ebola vaccine for medical use by the FDA in 2019. The ... Two Ebola vaccines that used viral vector technology were used to combat Ebola outbreaks in West Africa (2013-2016), and in the ... The Janssen vaccine uses serotype 26. Convidecia uses serotype 5. Zabdeno, the first dose of the Zabdeno/Mvabea Ebola vaccine, ...
"Ebola vaccine trial begins". BBC News. 17 September 2014. "Helen McShane". ndm.ox.ac.uk. "The Backstory: Vaccitech and its role ... The institute develops vaccines and carries out clinical trials for diseases including malaria, tuberculosis (vaccine MVA85A), ... ebola, and MERS-Coronavirus. In 2020, the institute successfully developed the Oxford-AstraZeneca COVID-19 vaccine, in a ... "The Oxford vaccine: the trials and tribulations of a world-saving jab". The Guardian. 26 June 2021. Archived from the original ...
... to lead a 10-institution national team developing improved therapeutics and vaccines for multiple strains of Ebola virus. In ... The Emory University Center for AIDS Research (CFAR) and the Emory Vaccine Center are world leaders in AIDS Vaccine Development ... "Cases of Ebola Diagnosed in the United States". Cdc.gov. Archived from the original on February 26, 2017. Retrieved October 20 ... "Emory Vaccine Dinner Club". Archived from the original on February 27, 2015. "About the Prevention Epicenters Program". Cdc/gov ...
Sullivan, Nancy; Yang, Zhi-Yong; Nabel, Gary (2003). "Ebola Virus Pathogenesis: Implications for Vaccines and Therapies". ... This research may lead to new ways to combat deadly viruses such as the Ebola virus and HIV. Research using wild-type mutations ... Research is also being done dealing with the manipulation of certain wild-type traits in viruses to develop new vaccines. ... Davidson, Nagar, Ribshtein, Shkoda, Perk, Garcia (2009). "Detection of Wild- and Vaccine-Type Avian Infectious ...
Other current Ebola research is focused on developing treatments or vaccines against the virus. Early investigations into ... Wilson JA, Bray M, Bakken R, Hart MK (August 2001). "Vaccine potential of Ebola virus VP24, VP30, VP35, and VP40 proteins". ... Sullivan N, Yang ZY, Nabel GJ (September 2003). "Ebola virus pathogenesis: implications for vaccines and therapies". Journal of ... there has been a considerable increase in research focused on developing a vaccine for Ebola. Shabman RS, Gulcicek EE, Stone KL ...
"Gavi commits to purchasing Ebola vaccine for affected countries". GAVI. Retrieved 11 December 2014. "Ebola Vaccine Protects ... Health Ministry Announce Ebola Vaccine". 2018-12-13. Retrieved 5 April 2020. "Saudi King gives $35 million grant for Ebola ... The UK government is co-funding clinical trials to find a safe vaccine for Ebola. Ten thousand doses of the drug are already ... "Vaccines alliance signs $5 million advance deal for Merck's Ebola shot". Reuters. 2017-01-20. Retrieved 2017-05-22. Burton, ...
CDC Emergency Ebola Vaccine, Taskforce. (7 September 2017). "Considerations for use of Ebola vaccine during an emergency ... "Ebola Ring Vaccination Results 12 April 2019" (PDF). www.who.int. 12 April 2019. Retrieved 17 April 2019. "First Ebola vaccine ... "Can The New Ebola Vaccine Stop The Latest Outbreak?". NPR.org. Retrieved 2018-05-16. Mole, Beth (2019-04-16). "As Ebola ... The vaccine used was rVSV-ZEBOV. Ring vaccination has been used extensively in the 2018 Kivu Ebola outbreak, with over 90,000 ...
"Hundreds in Guinea get Ebola vaccine in fight against flare-up". Fox News. 1 April 2016. Retrieved 2 April 2016. "Ebola claims ... Ebola virus epidemic in Sierra Leone Ebola virus epidemic in Liberia Ebola virus disease in Mali Ebola virus disease in Nigeria ... After a trial run of an experimental Ebola vaccine involving 11,000 people in Guinea, Merck, the vaccine's manufacturer, ... CDC Ebola in Guinea CDC Ebola outbreak map "Ebola outbreak: timeline". Médecins Sans Frontières/Doctors Without Borders. ...
"Ebola treatment pioneered at ASU". Retrieved 28 August 2019. "Nyet News Report (12.06.11): "Ebola vaccine developed"". Ynetnews ... In 2011, he and his team at the Biodesign Institute were developing a vaccine for the Ebola virus using mice. An outcome of ... Arntzen, C (2015). "Plant-made pharmaceuticals: from 'Edible Vaccines' to Ebola therapeutics". Plant Biotechnol J. 13 (8): 1013 ... "A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge". Proceedings of the National Academy of ...
Symptoms are similar to Ebola virus disease. There are no vaccines or antiviral treatments for Marburg. An outbreak of an ... "Equatorial Guinea declares outbreak of Ebola-like Marburg virus". BNO News. Archived from the original on 20 February 2023. ...
Viral vectors had previously been approved as ebola vaccines. Eckhart Buddecke: Molekulare Medizin. ecomed-Storck GmbH, 2002, ... Genetic vaccines thus include DNA vaccines, RNA vaccines and viral vector vaccines. Most vaccines other than live attenuated ... A genetic vaccine (also gene-based vaccine) is a vaccine that contains nucleic acids such as DNA or RNA that lead to protein ... Examples of genetic vaccines approved for use in humans include the RNA vaccines tozinameran and mRNA-1273, the DNA vaccine ...
"Nearly 700 get Ebola vaccine in Congo; more cases possible". Fox News. 1 June 2018. Retrieved 1 June 2018. "Ebola virus disease ... and was the first time that vaccination with the rVSV-ZEBOV Ebola vaccine had been attempted in the early stages of an Ebola ... vaccine - a recently developed experimental Ebola vaccine, produced by Merck - to try to suppress the outbreak. This live- ... Declaration of End of Ebola Virus Disease Outbreak". ReliefWeb. Retrieved 26 July 2018. "We finally have an Ebola vaccine. And ...
... establishing a successful pipeline of candidate vaccines against HCV, malaria, RSV and Ebola. These vaccines were tested in ... Riccardo Cortese, former head of the Genome Biology Unit, talks about the Ebola vaccine candidate developed by his start-up, ... 2016). "A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA". The New England Journal of Medicine. 374 (17): 1635 ... 2017). "Chimpanzee Adenovirus Vector Ebola Vaccine". The New England Journal of Medicine. 376 (10): 928-938. doi:10.1056/ ...
Field trials for a Russian Ebola vaccine were carried out at the centre, and the vaccine was officially launched in August 2017 ... "Russia to fund Ebola vaccine trials , IOL News". Retrieved 8 September 2017. "Santé : l'hôpital RUSAL lance la vaccination ... During the 2014 Ebola outbreak in West Africa, UC Rusal provided logistical support to the international relief efforts. In ... "UC RUSAL builds US$10m centre in Guinea to combat Ebola , Trade and Forfaiting Review". www.tfreview.com. Archived from the ...
"Ebola/Marburg Vaccine Development" (Press release). National Institute of Allergy and Infectious Diseases. 2008-09-15. Archived ... There are currently no Food and Drug Administration-approved vaccines for the prevention of MVD. Many candidate vaccines have ... Ebola virus, Marburg virus and Venezuelan equine encephalitis virus". Vaccine. 21 (25-26): 4071-4080. doi:10.1016/S0264-410X(03 ... "Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses". Nature Medicine. 11 (7): 786 ...
Human Vaccines Project. Retrieved 2019-01-27. Nebehay, Stephanie; Kell, Kate. "WHO expects around 200,000 Ebola vaccine doses ... "Final trial results confirm Ebola vaccine provides high protection against disease". www.who.int. Retrieved 2019-03-03. "Ebola ... In aftermath of the 2014 Democratic Republic of the Congo Ebola virus outbreak Kieny stated that the vaccine may not be ... Kieny even audaciously signed up herself as a test subject for the safety of new Ebola vaccines being developed, amidst ...
"Sabin Institute To Develop GSK's Ebola and Marburg Virus Vaccines". www.precisionvaccinations.com. Retrieved 2020-05-20. " ... "Status of vaccine research and development of vaccines for Chagas disease". Vaccine. 34 (26): 2996-3000. doi:10.1016/j.vaccine. ... "Status of vaccine research and development of vaccines for leishmaniasis". Vaccine. 34 (26): 2992-2995. doi:10.1016/j.vaccine. ... "IVI and Sabin Vaccine Institute Form a Strategic Alliance to Develop Vaccines for the World's Poor". International Vaccine ...
The New Zealand Prime Minister John Key called the idea of homeopathy for Ebola "barking mad". The sentence was announced on 14 ... Timmer, John (2014-12-22). "Australian court to penalize homeopaths for claiming vaccine alternative". Ars Technica. Retrieved ... Bennett, Adam (2014-10-30). "Fight Ebola with homeopathy - MP". New Zealand Herald. Retrieved December 22, 2014. Su, Reissa ( ... "Homeopathy Plus! director Fran Sheffield banned from promoting 'vaccines'". Sydney Morning Herald. October 14, 2015. Retrieved ...
An example is the RVSV-ZEBOV vaccine licensed to Merck that is being used in 2018 to combat ebola in Congo. T-cell receptor ... The subgroup of genetic vaccines encompass viral vector vaccines, RNA vaccines and DNA vaccines. Viral vector vaccines use a ... Examples include IPV (polio vaccine), hepatitis A vaccine, rabies vaccine and most influenza vaccines. Toxoid vaccines are made ... RNA vaccines and DNA vaccines are examples of third generation vaccines. In 2016 a DNA vaccine for the Zika virus began testing ...
"Ebola vaccine found safe in humans trials". Outlook India. Press Trust of India. 9 October 2017. Retrieved 3 November 2021. ... He also contributed to the development of vaccines for Ebola which were shown to be safe and effective in clinical trials by ... April 2016). "Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe". New England Journal of Medicine. 374 (17): 1647-1660 ... Withers, Iain (1 February 2018). "How prepared are we for the next Ebola-scale epidemic?". The Telegraph. ISSN 0307-1235. ...
22 December Ebola virus disease found to be 70-100% prevented by rVSV-ZEBOV vaccine, making it the first proven vaccine against ... 22 December 2016). "Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results ... Berlinger, Joshua (22 December 2016). "Ebola vaccine gives 100% protection, study finds". CNN. Retrieved 27 December 2016. " ... "First new HIV vaccine efficacy study in seven years has begun". NIH. 28 November 2016. Retrieved 1 December 2016. "Testing ...
"Residents and traders to get Ebola vaccine". Rwanda Today. Retrieved 2020-06-07. "Board of Directors". rbc.gov.rw. 2019-12-18. ... The past few years, Karita has been working on the Umurinzi Ebola Vaccination Program to prevent the spread of Ebola, but the ...
Freudenthal, Emmanuel (10 June 2019). "A short history of an Ebola vaccine". ConverseAfrica.com. v t e (Articles with short ... The variant of the Ebola virus that infected N'Seka was originally named "Zaïre virus strain Mayinga" (now Ebola virus variant ... She died from Ebola virus disease during the 1976 epidemic in Zaïre. She has been incorrectly identified as the index case by ... "Ebola hemorrhagic fever in Zaire, 1976" (PDF). Bulletin of the World Health Organization. 56 (6): 271. 1978. Archived from the ...
December 22 - A study finds the VSV-EBOV vaccine against the Ebola virus between 70 and 100% effective, thus making it the ... Berlinger, Joshua (December 23, 2016). "Ebola vaccine gives 100% protection, study finds". CNN. Archived from the original on ... first proven vaccine against the disease. December 23 - The United Nations Security Council adopts Resolution 2334 condemning " ...
2. Ebola vaccine. Ebola vaccine can prevent Ebola virus disease (Zaire Ebola vaccine is a live virus vaccine that is ... the Ebola vaccine only contains a gene from the Ebola virus goril as, and chimpanzees). Outbreaks of Ebola virus disease ... Ebola vaccine contains a live virus. It is possible that been seriously injured by certain medicines or vaccines. the vaccine ... Ebola vaccine is recommended by CDC for adults 18 years are infected with the virus or who have died of Ebola and older at high ...
Ebola vaccines are vaccines either approved or in development to prevent Ebola. As of 2022, there are only vaccines against the ... "Ebola Vaccine Information Statement". U.S. Centers for Disease Control and Prevention (CDC). June 2022. Ebola Vaccines at the U ... Scholia has a topic profile for Ebola vaccine. "Ebola Vaccines". Drug Information Portal. U.S. National Library of Medicine. " ... The Wellcome Trust-CIDRAP Ebola Vaccine Team B (January 2017). Completing the development of Ebola vaccines: current status, ...
Evaluation in Nonhuman Primates of Vaccines against Ebola Virus Thomas W. Geisbert*, Peter Pushko*, Kevin Anderson*, Jonathan ... Evaluation in Nonhuman Primates of Vaccines against Ebola Virus. ... Sections of spleen from Ebola virus (EBOV)-infected animals. ...
Information you need to know about the Ebola vaccine. Vaccine Information Statements (VISs). ... Ebola vaccine. Ebola vaccine is a live virus vaccine that is administered as a single dose by injection into a muscle. The ... Because the Ebola vaccine only contains a gene from the Ebola virus instead of the whole Ebola virus, it cannot cause Ebola ... Ebola vaccine can prevent Ebola virus disease (Zaire ebolavirus).. Ebola virus disease is a rare disease that most commonly ...
... highlights the need for an Ebola vaccine stockpile, Berkley says. "It basically says we need to have a supply of vaccine ... With the Ebola outbreak in West Africa stubbornly hanging on, officials have brokered an agreement to ensure that a vaccine is ... "We are in the most tenuous situation with regard to Ebola vaccines that weve seen since we started all of this," says Michael ... Much of the devastation wrought by Ebola in West Africa might have been prevented with a vaccine. Credit: Misha Hussain/Reuters ...
Human trials of the Ebola vaccine have been temporarily shut down due to adverse side effects. What will it take to get it up ... Thomas Geisbert of the University of Texas, an Ebola vaccine researcher who has worked with most of the vaccines coming to ... Though the replication-competent VSV-based vaccine trial is having difficulty, the other leading Ebola vaccine candidate is not ... Matthias Schnell, the researcher behind the Ebola-rabies combination vaccine at the Jefferson Vaccine Center in Philadelphia. " ...
... which is about the first known Ebola outbreak, the one that gave it its name, in southern Sudan. Thats about 150 miles, as the ... well within the migratory range of an Ebola carrying fruit bat. ... Ebola: Have more knowledge, need vaccine more * facebook * ... That would be a good argument to get a damn vaccine.. But, one could argue that even though Ebola is known to have been around ... there was not much movement to get a vaccine. Then, one day, a fruit bat, carrying ebola, dropped some bat spit covered fruit ...
Canadian team prepares to study its own vaccine soon ... Clinical trialDrug research and developmentEbola vaccineEbola ... A clinical trial to evaluate an experimental Ebola vaccine has been launched in Mali by the Center for Vaccine Development (CVD ... A recent increase in funding for Ebola vaccine research is also enabling GSK to begin manufacturing at least 10,000 additional ... The trial is one of two possible clinical studies of an Ebola vaccine candidate that could begin this month. ...
Ebola Deaths May Reach Over 1,000 By Next Week (Exclusive Interview). By Sandy Dechert ... West Africa may even reach 1,000 deaths from Ebola this weekend. Thats just a guess, but not a bad guess, considering the ...
... has granted marketing approval to its two-dose Ebola vaccine regimen for the prevention of Ebola Virus caused by Zaire strain. ... The approval of the vaccine is a landmark moment for the company as it brings forth a vaccine to treat the deadly Ebola virus. ... has granted marketing approval to its two-dose Ebola vaccine regimen for the prevention of Ebola Virus caused by Zaire strain. ... We note that another company, Merck MRK, received FDA approval in December 2019 for its vaccine Ervebo (V920) to treat Ebola. ...
First products for Ebola Virus Disease prequalified WHO Prequalification Unit (PQT) added the below new products to its ...
As the race for an Ebola vaccine continues, experts gathered in Ghana from 8-10 April 2015 to review the clinical trial ... application for the Janssen Ebola Zaire Vaccine that will take place in Sierra Leone. ... the water we drink and the medicines and vaccines that treat and protect us. The Organization aims to provide every child, ... efforts continue to find an effective vaccine that can fight the virus both now and for future generations. ...
The World Health Organization and Merck approved using the vaccine in Congo. ... Why this vaccine?. This vaccine was developed to help protect people who have not yet been infected with Ebola. It has been ... What are the current treatments for Ebola?. There is no cure for Ebola, so the mainstay of treatment for Ebola virus involves ... Ebola vaccine deployed in Congo: What to know about the experimental approach. The World Health Organization and Merck approved ...
... but researchers are busy working on vaccines as the virus continues to spread in West Africa. In a few areas in Liberia, cases ... No cases of Ebola remain in the United States at the moment, ... Ebola Ebola Update: Vaccines in Tests, Spike in Mali, Dips in ... No cases of Ebola remain in the United States at the moment, but researchers are busy working on vaccines as the virus ... The vaccine contains a cold virus that infects chimpanzees, along with a single gene from the Ebola virus, which the ...
Our commitment goes beyond developing a vaccine for future use. Johnson & Johnson disaster response efforts continue through ... Janssens Ebola vaccine regimen was shipped and given to patients in late 2019 as part of a vaccination campaign in Rwanda and ... A study volunteer receives the vaccine in the Democratic Republic of the Congo (DRC) during the 2018-2020 outbreak ... A patient receives the vaccine in Rwanda as part of the UMURINZI vaccination campaign ...
Economist report on new Ebola vaccines underlines dangers - EbolaGate. *Economist report on new Ebola vaccines underlines ... Part II: Rockefeller Vaccine Secret Revealed - EbolaGate. *FINAL NAILS IN THE EBOLA SCAM COFFIN: The 2014 Ebola Outbreak is a ... VRM: Special Report « Vaccine Resistance Movement. *Bill Gates - Ebola, Death and Vaccines: Add In WHO, PATH, GAVI, UNICEF, ... Hoping Ebola Vaccines Are As Effective As Smallpox and Polio Vaccines? You Might Seriously Want to Rethink That - EbolaGate. ...
A new experimental Ebola vaccine displayed 100 percent efficacy in a clinical trial involving thousands in Guinea, Africa, ... A new experimental Ebola vaccine displayed 100 percent efficacy in a clinical trial involving thousands in Guinea, Africa, ... The vaccine, however, is not perfect. It appears to work only against one of the two most common strains of Ebola and it is not ... Experimental Ebola vaccine offers complete protection in clinical trial. Brian Zimmerman - Friday, December 23rd, 2016. ...
New studies show one shot of this experimental vaccine can trigger fast protection. Read more... ... New studies show one shot of this experimental vaccine can trigger fast protection.. Read more... ...
The head of the World Health Organization said Wednesday that he expects the first doses of Ebola vaccine targeting the strain ... WHO: 1st Ebola vaccines to arrive in Uganda next week Facebook , path id="pathAttribute" d="M 8.917969 7.773438 L 367.417969 ... vaccines alliance Gavi signed an agreement with Merck to secure 300,000 doses of its candidate Ebola vaccine for use in ... WHO: 1st Ebola vaccines to arrive in Uganda next week. Nov 16, 2022, 8:01 AM , Updated: Nov 18, 2022, 1:21 am ...
In addition, the vaccine targets dendritic cells, which are the same cells that Ebola and Marburg attack, says Geisbert. These ... According to Geisbert, this is the first vaccine system, or platform, that has protected nonhuman primates from both Ebola and ... New Ebola, Marburg Vaccines Effective in Animal Models. June 6, 2005. Article ... have developed vaccines against the Ebola and Marburg viruses that have been shown to be effective in non-human primates. ...
Antibodies from an Ebola survivor protected animals from deadly ebolaviruses and could help inform the development of potential ... Antibodies from Ebola survivor could lead to treatments and vaccines. At a Glance. *Antibodies from an Ebola survivor protected ... The 2014-16 Ebola outbreak in West Africa highlighted the need for an effective treatment or vaccine. Researchers have been ... The findings will help inform the development of potential treatments and vaccines for Ebola and related viruses. ...
Infectious Disease > Ebola Zaire Ebola Vaccines Produce Antibody Responses as Early as 14 Days. - Responses in adults and kids ... since vaccines are often distributed only when Ebola outbreaks occur. "Given that vaccines against EVD have typically been ... Three vaccine regimens for Zaire Ebola virus disease (EVD) produced antibody responses in adults and children, according to the ... Source Reference: PREVAC Study Team "Randomized trial of vaccines for Zaire Ebola virus disease" N Engl J Med 2022; DOI: ...
An Ebola vaccine will take the next critical steps in development under a $24.75 million contract through May 2020 between the ... "We can prevent future epidemics by acting quickly and decisively to complete development of Ebola vaccines and treatments for ... There currently are no vaccines or treatments approved for use against Ebola. The Centers for Disease Control and Prevention ( ... Todays agreement builds on previous Ebola vaccine development efforts undertaken by BPS with support from ASPRs Biomedical ...
In the first test of an Ebola virus vaccine in the US, the University of Maryland announced it will soon start human trial. ... head of Ebola vaccine research at Glaxo, said "We are accelerating development of this Ebola candidate vaccine at an ... The vaccine will be delivered in an adenovirus, that does not contain the full virus, just a single Ebola protein. ... In the first test of an Ebola virus vaccine in the US, the University of Maryland announced it will soon start human trial. ...
Collins argument and appropriates millions of dollars for Ebola research or an Ebola vaccine, and the magic bullet doesnt ... its still false to argue that with more money wed have an Ebola vaccine. Vaccine and drug development just simply doesnt ... No, Budget Cuts Didnt Prevent an Ebola Vaccine Scientists push back on NIH chiefs claims. ... Collins should be out there pointing out that the reason were even in a position to develop an Ebola vaccine is because of our ...
Canada has approved a vaccine to prevent Ebola in non-pregnant and otherwise healthy adults aged 18 and older. ... Canada approves Ebola virus vaccine for adults exposed to the deadly disease. A health-care professional adjusts her mask ... Canada has approved a vaccine to prevent Ebola in non-pregnant and otherwise healthy adults aged 18 and over following exposure ... Canada has approved a vaccine to prevent Ebola in non-pregnant and otherwise healthy adults aged 18 and older. ...
It is "vital that we ensure global preparedness for Ebola given that the worlds largest Ebola outbreaks have taken place in ... to define the required data set for filing of the Janssen Ebola vaccine regimen under the FDAs Animal Rule licensure pathway. ... for its investigational Ebola vaccine regimen.. The companys Janssen division is seeking license for the drug for the ... The company confirmed that two MAAs have been submitted in parallel supporting each vaccine in the two-dose regimen (Ad26.ZEBOV ...
Channels Incorporated Limited. All rights reserved.. ...
The Guardian article titled Ebola vaccine offered in exchange for sex, Congo taskforce meeting told, was published on Tuesday ... "However, the IRC clarified that the analysis of their raw data revealed that no specific Ebola-related services was mentioned ... These women and girls expressed their fears and concerns about the Ebola response considering the social and security context ... "In focus group discussions, some participants expressed concerns about women and girls being offered Ebola-related services in ...
  • On 20 January, Gavi, the Vaccine Alliance, announced that it has paid US$5 million to Merck, the manufacturer of the first Ebola vaccine shown to protect against the virus in a human clinical trial. (nature.com)
  • In return for the payment from Gavi, Merck promises that it will seek to have the vaccine approved by a regulatory agency by 2017. (nature.com)
  • A vast store of Ebola vaccines has been manufactured in the past year - approximately 2 million doses of three candidate vaccines made by Merck, Johnson & Johnson and GlaxoSmithKline. (nature.com)
  • also known as Doctors Without Borders), which administered the Merck vaccine trial in West Africa, plans to continue using the vaccines in investigative mode if another outbreak occurs. (nature.com)
  • The Gavi agreement is intended to ease that problem by requiring Merck to seek an 'emergency use assessment and listing' - permission from the WHO to use the vaccine wherever it is needed without having to organize a clinical trial. (nature.com)
  • Gavi says that Merck has already begun those discussions with the WHO, and that ultimately it might buy other vaccines if they are approved. (nature.com)
  • Unfortunately, in the face of nearly 7,000 dead and over 18,000 confirmed cases, the Merck-NewLink stage 1 Ebola vaccine trial has hit a snag. (thedailybeast.com)
  • We note that another company, Merck MRK , received FDA approval in December 2019 for its vaccine Ervebo (V920) to treat Ebola. (nasdaq.com)
  • The ChAd3-ZEBOV, developed by GlaxoSmithKline (GSK), in collaboration with the US National Institute of Allergy and Infectious Diseases (NIAID) is in phase III clinical trial in Liberia and rVSV-ZEBOV, developed by NewLink Genetics and Merck Vaccines USA, in collaboration with the Public Health Agency of Canada and WHO entered Phase III trials in Guinea. (who.int)
  • The World Health Organization and Merck approved using the vaccine in Congo. (go.com)
  • The vaccine, which is referred to as both VSV ZEBOV and V920, was developed by Merck and has demonstrated the ability to cut the risk of infection in human trials. (go.com)
  • The vaccine was manufactured by Kenilworth, N.J.-based Merck, which was previously granted Breakthrough Therapy Designation from the U.S. Food and Drug Administration. (beckershospitalreview.com)
  • Earlier this month, vaccines alliance Gavi signed an agreement with Merck to secure 300,000 doses of its candidate Ebola vaccine for use in research and beyond. (ktar.com)
  • Janssen and Merck Sharp and Dohme provided the vaccines used in the study. (medpagetoday.com)
  • The study team reported relationships with Merck, Johnson & Johnson, the London School of Hygiene and Tropical Medicine, the National Institute of Allergy and Infectious Diseases, Janssen Vaccines and Prevention, and Janssen Pharmaceuticals. (medpagetoday.com)
  • Since the 2014-2015 epidemic, BPS has worked with Merck and Co., Inc. to advance a vaccine, known as V920, through multiple clinical studies, including studies conducted among health care professionals working in West Africa. (infectioncontroltoday.com)
  • The Merck vaccine has also been approved in some African countries. (cp24.com)
  • And it might at some point provide a tidy windfall for Merck, the company now developing an Ebola vaccine designed at Canada's National Microbiology Laboratory in Winnipeg. (cp24.com)
  • In late November, Merck bought the licence to develop the Winnipeg Ebola vaccine for $50 million from NewLink Genetics, which acquired it in 2010 for $205,000. (cp24.com)
  • Merck will learn whether the FDA will approve V920 by mid-March, giving it a shot at becoming the first company to receive clearance to sell a vaccine against the virus in the U.S. (fiercebiotech.com)
  • Merck is going to the regulators after generating clinical evidence that V920, also known as rVSV∆G-ZEBOV-GP, has protected people from Ebola in recent outbreaks. (fiercebiotech.com)
  • The subsequent flurry of regulatory activities is intended to enable Merck to supply licensed vaccines to support global public health preparedness and security efforts. (fiercebiotech.com)
  • Merck is working to get a German production site cleared to supply the licensed vaccine. (fiercebiotech.com)
  • Merck is already supplying the vaccine on an investigational basis, but getting V920 licensed would clear some barriers to access such as the need to obtain informed consent from patients. (fiercebiotech.com)
  • According to the WHO, vaccines were donated by Merck, with the public-private vaccine partnership Gavi contributing $1 million toward operational costs. (vox.com)
  • KENILWORTH, N.J.-( BUSINESS WIRE )-Merck, known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has accepted the Biologics License Application (BLA) and granted priority review for Merck's investigational Ebola vaccine (V920), under review for the prevention of disease caused by the Ebola Zaire virus. (merck.com)
  • Merck has worked with government partners and the global health community to accelerate development of our investigational V920 Ebola vaccine. (merck.com)
  • In parallel to its regulatory efforts, Merck has remained steadfast in its commitment to scale-up the number of investigational V920 Ebola vaccine doses being produced to help international public health officials and government authorities meet ongoing, unpredictable, and evolving outbreak response needs in the Democratic Republic of the Congo (DRC) and neighboring countries. (merck.com)
  • Since May 2018, Merck has donated and shipped more than 245,000 1.0mL investigational V920 Ebola vaccine doses to the World Health Organization (WHO) in response to requests by the WHO. (merck.com)
  • In addition, in June 2019, Merck started executing an updated replenishment strategy to increase investigational V920 Ebola vaccine supply, based on ongoing consultations with the U.S. Department of Health and Human Services, WHO and Gavi (the Vaccine Alliance). (merck.com)
  • In late 2014, when the Ebola outbreak in western Africa was at its peak, Merck licensed V920 from NewLink Genetics. (merck.com)
  • It will test two Ebola vaccines: ChAd3, developed by the US National Institutes of Health and GSK, and VSV-EBOV, which was developed by the Canadian government and licensed to New Link Genetics and Merck. (superdoctors.com)
  • Also, WHO said that an international vaccine-focussed organization, GAVI , provided $5 million to Merck, one of the vaccine's manufacturers, towards its future procurement once the vaccine is approved, prequalified and recommended by WHO. (un.org)
  • As part of this agreement, Merck committed to ensure that 300,000 doses of the vaccine are available for emergency use in the interim, and to submit the vaccine for licensure by the end of 2017. (un.org)
  • Merck has also submitted the vaccine to WHO's Emergency Use and Assessment Listing procedure, a mechanism through which experimental vaccines, medicines and diagnostics can be made available for use prior to formal licensure. (un.org)
  • As well as the Janssen and GSK/NIH Ebola vaccines, Merck & Co has recently bought the rights to a third Ebola vaccine being developed by the biotech company NewLink Genetics. (pharmexec.com)
  • The trial vaccine, formally called rVSV-ZEBOV but more commonly known as VSV-EBOV, was supplied by the pharmaceutical firm Merck Sharp & Dohme. (wuft.org)
  • The vaccine was licenced to NewLink Genetics, and on November 24, 2014, NewLink Genetics and Merck announced their collaboration on the vaccine. (un.org)
  • Researchers working on a vaccine against the Zaire strain of Ebola virus, which is causing the current outbreak, say that nearly 200 people have now received an experimental vaccine that was developed by the U.S. National Institutes of Health (NIH) and GlaxoSmithKline. (livescience.com)
  • New studies show one shot of this experimental vaccine can trigger fast protection. (military-quotes.com)
  • In a small trial, an experimental vaccine protected 100 percent of participants who were at high risk for the virus. (wgbh.org)
  • In a first, the experimental vaccine is being deployed in the DRC to try to stop an outbreak from spreading. (vox.com)
  • If the experimental vaccine works to prevent Ebola from spreading, it could mean major outbreaks involving Ebola's Zaire strain, like the one we saw in West Africa a few years ago, will be a thing of the past. (vox.com)
  • As the WHO opens its third emergency meeting on Ebola, Johnson and Johnson says it's speeding up work on an experimental vaccine against the disease - putting pressure on its main rivals in the vaccine race, GSK and NewLink Genetics, to do the same. (thenationalnews.com)
  • An experimental vaccine against the Ebola virus has proved effective and well-tolerated in the first human trial of a candidate Ebola drug. (facmedicine.com)
  • Further, although reports of long-term immunogenicity following DNA or other experimental vaccine administration are lacking, results showed that the anti-Ebola virus glycoprotein DNA vaccine induced long-term immune responses in the nonhuman primates. (infectiousdiseaseadvisor.com)
  • The findings of this study provide the basis for advancing this experimental vaccine to an NIH phase I clinical study. (globalbiodefense.com)
  • Ebola virus disease risk of infection. (cdc.gov)
  • During the early 21st century, several vaccine candidates displayed efficacy to protect nonhuman primates (usually macaques) against lethal infection. (wikipedia.org)
  • The trial used a ring vaccination protocol that first vaccinated all the closest contacts of new cases of Ebola infection either immediately or after 21 days. (wikipedia.org)
  • The trial will continue to assess whether the vaccine is effective in creating herd immunity to Ebola virus infection. (wikipedia.org)
  • Health care workers and family and friends in close contact with people with Ebola virus disease are at the highest risk of infection. (cdc.gov)
  • Also, and this is from new research, now that Ebola has infected tens of thousands, it has a temporary reservoir in the post-infection population. (scienceblogs.com)
  • It is now understood that survivors can have ebola in their systems for long periods of time after infection, and that in some cases, they can pass this on. (scienceblogs.com)
  • A seemingly healthy mother in Guinea passed the virus to her nine-month-old daughter in breast milk, and the child died from Ebola-virus infection in August 2015. (scienceblogs.com)
  • Researchers] traced a cluster of new Ebola cases to a man who transmitted the virus to a sexual partner 17 months after recovering from his infection. (scienceblogs.com)
  • There is no cure for Ebola, so the mainstay of treatment for Ebola virus involves supportive care to maintain adequate organ function, giving the patient's immune system time to mobilize and eliminate the infection. (go.com)
  • In a study published in the June issue of Nature Medicine , Canadian researchers Dr. Heinz Feldmann and Dr. Steven Jones of PHACs National Microbiology Laboratory and Dr. Thomas Geisbert of USAMRIID report that the vaccines have proven 100 percent effective in protecting monkeys against infection from these often deadly viruses. (infectioncontroltoday.com)
  • Given that vaccines against EVD have typically been administered during an outbreak to populations at risk for infection, it was important to investigate the early kinetics of the antibody response. (medpagetoday.com)
  • The bill -- S.2917, also known as 'Adding Ebola to the FDA Priority Review Voucher Program Act' -- dangles a sizable carrot meant to entice pharmaceutical companies into developing vaccines and therapies to prevent or cure infection with the virus and other related pathogens in the filovirus family. (cp24.com)
  • Despite falling infection rates in West Africa, the risk that the current Ebola outbreak may not be brought completely under control remains. (superdoctors.com)
  • The vaccine is the first to prevent infection from one of the most lethal known pathogens, and the findings add weight to early trial results published last year," WHO said in a news release, noting the results of the latest trial, published earlier today in the medical journal The Lancet . (un.org)
  • The vaccine regimen does not contain any replicating virus, so there is no risk of infection with Ebola. (pharmexec.com)
  • Based on these positive results from the first human trial of this candidate vaccine, we are continuing our accelerated plan for larger trials to determine if the vaccine is efficacious in preventing Ebola infection," says Fauci. (facmedicine.com)
  • The objectives of the trial are two-fold: to assess if the vaccine protects the contacts who were vaccinated and if vaccinating the contacts will create a buffer - or ring - of protected individuals - around the index case to prevent further spread of the infection," WHO said. (un.org)
  • Hundreds of people were tested or monitored for potential Ebola virus infection, [16] but the two nurses were the only confirmed cases of locally transmitted Ebola. (wikipedia.org)
  • The live recombinant vaccine has shown effectiveness of 97.5% in preventing infection among 90,000 individuals in an active Ebola virus outbreak in the Democratic Republic of Congo. (medscape.com)
  • Recent studies show that contact with the Ebola virus through the mucus membranes that line the respiratory tract results in infection, suggesting that airway linings may be important portals of entry for the virus. (globalbiodefense.com)
  • A single vaccination with the aerosol developed by the researchers protected non-human primates against the severe disease and death caused by lethal Ebola infection. (globalbiodefense.com)
  • Ebola disease is caused by an infection with one of a group of viruses, known as ebolaviruses, that are found primarily in sub-Saharan Africa. (cdc.gov)
  • What if there is a serious postpone Ebola vaccination until a future visit. (cdc.gov)
  • The study was a randomized cluster (ring) vaccination study in which 3,537 contacts, and contacts of contacts, of individuals with laboratory-confirmed Ebola virus disease (EVD) received either "immediate" or 21-day "delayed" vaccination. (wikipedia.org)
  • In a comparison of cases of EVD among 2,108 individuals in the "immediate" vaccination arm and 1,429 individuals in the "delayed" vaccination arm, Ervebo was determined to be 100% effective in preventing Ebola cases with symptom onset greater than ten days after vaccination. (wikipedia.org)
  • In some cases, your health care provider may decide to postpone Ebola vaccination until a future visit. (cdc.gov)
  • Pain, swelling, and redness where the shot is given can happen after Ebola vaccination. (cdc.gov)
  • Joint pain or swelling can occur after Ebola vaccination. (cdc.gov)
  • Before the West Africa outbreak, only a handful of people had ever received a vaccination against Ebola. (nature.com)
  • Nurses working with the World Health Organization (WHO) administer the Ebola vaccine to a local doctor at the town all of Mbandaka, Democratic Republic of Congo, May 21, 2018 during the launch of the Ebola vaccination campaign. (go.com)
  • The WHO has received approval to use an experimental Ebola vaccine, using a 'ring vaccination' approach, around the epicenter of the outbreak in the Congo. (go.com)
  • Residents gather at the town Hall of Mbandaka, Democratic Republic of Congo (DRC), May 21, 2018 during the launch of the Ebola vaccination campaign. (go.com)
  • This vaccine was designed for use in a so-called 'ring vaccination' approach, a strategy used in 1977 to control smallpox. (go.com)
  • Janssen's Ebola vaccine regimen was shipped and given to patients in late 2019 as part of a vaccination campaign in Rwanda and a study in the DRC. (jnj.com)
  • No one who contracted Ebola within the first nine days post-vaccination were counted against the vaccine, because it was assumed they had already been infected prior to immunization. (beckershospitalreview.com)
  • However, the IRC clarified that the analysis of their raw data revealed that no specific Ebola-related services was mentioned during the discussions, not even vaccination. (africanews.com)
  • A breathable respiratory vaccine has been shown to be effective in protecting monkeys against Ebola for as long as a year after vaccination. (ibtimes.co.uk)
  • When mothers received COVID-19 vaccination during pregnancy, the vaccine effectiveness against COVID-related hospitalization was 35% among infants less than six months and 54% in the initial three months of their life. (medicaldaily.com)
  • Among the 5,837 people who received the vaccine, no Ebola cases were recorded 10 days or more after vaccination. (un.org)
  • In comparison, there were 23 cases 10 days or more after vaccination among those who did not receive the vaccine. (un.org)
  • In addition to showing high efficacy among those vaccinated, the trial also shows that unvaccinated people in the rings were indirectly protected from Ebola virus through the ring vaccination approach. (un.org)
  • In the immediate vaccination group, there were no cases of Ebola virus disease with symptom onset at least 10 days after randomization," the researchers say, "whereas in the delayed vaccination group there were 16 cases of Ebola virus disease from seven clusters, showing a vaccine efficacy of 100 percent. (wuft.org)
  • Researchers say that for both groups - those who got the vaccine immediately and those who received it after a delay - no new Ebola cases were diagnosed starting at six days after vaccination. (wuft.org)
  • The World Health Organization (WHO) announced today that it will begin conducting Ebola vaccination trials in Guinea this week, which if found effective, could be the "game-changer to finally end the epidemic" that has affected nearly 24,000 people, mostly in West Africa. (un.org)
  • Carter has been advising preventive vaccination campaigns in the DRC's neighboring countries of Uganda and South Sudan, preparing them for the chance that Ebola might slip across the borders of the DRC. (cdc.gov)
  • The anti-Ebola virus glycoprotein DNA vaccination was delivered in a multiple-injection regimen by intramuscular administration and in a 2-injection regimen by intradermal administration, followed by electroporation. (infectiousdiseaseadvisor.com)
  • The study characterized the immune responses generated by vaccination against Ebola delivered to the respiratory tract as either an aerosol or liquid. (globalbiodefense.com)
  • Refer to vaccine guidelines for vaccination timing during and following treatment. (medscape.com)
  • With the theme, vaccines bring us closer, World Immunization Week shows how vaccination connects us to the people, goals and moments that matter most, helping improve the health of everyone everywhere throughout life. (bvsalud.org)
  • Ebola vaccine is a live virus vaccine that is administered as a ebolavirus). (cdc.gov)
  • As of 2022, there are only vaccines against the Zaire ebolavirus. (wikipedia.org)
  • The researchers surveyed 349 antibodies derived from the blood of one survivor of the West African Ebola outbreak, which was caused by the Zaire strain of ebolavirus. (nih.gov)
  • The company's Janssen division is seeking license for the drug for the prevention of Ebola Virus Disease (EVD) specifically caused by Zaire ebolavirus species. (pharmatimes.com)
  • In July 2021, the Company announced results of preclinical efficacy studies of its Sudan ebolavirus (SUDV) vaccine candidate, in which a single dose of the vaccine protected 100% of animals challenged with a lethal dose of SUDV. (gabio.org)
  • Current evidence shows that the FDA-approved Ervebo vaccine, which is highly effective against the Zaire ebolavirus, does not provide cross protection against the Sudan ebola-virus, WHO said. (staradvertiser.com)
  • WHO has identified six possible candidate vaccines against the Sudan ebolavirus in different stages of development, including the one from JABSOM, with promising data. (staradvertiser.com)
  • It provides protection against only the Zaire ebolavirus species and does not protect against other species of Ebola virus or Marburg virus. (msdmanuals.com)
  • Ad26.ZEBOV/MVA-BN-Filo is given as an injection into a muscle in a 2-dose series for the prevention of Ebola virus disease caused by the Zaire ebolavirus species in people 1 year of age and older. (msdmanuals.com)
  • [ 1 ] The outbreak of Ebola virus disease in West Africa from 2014 to 2016, involving Zaire ebolavirus , was the largest outbreak of Ebola virus disease in history. (medscape.com)
  • Although Ebola disease is rare, people can get the disease through contact with an infected animal (bat or nonhuman primate) or a sick or dead person infected with an ebolavirus. (cdc.gov)
  • ERVEBO vaccine has been found to be safe and protective against only the Zaire ebolavirus species of ebolavirus. (cdc.gov)
  • Because affects people and nonhuman primates (such as monkeys, the Ebola vaccine only contains a gene from the Ebola virus goril as, and chimpanzees). (cdc.gov)
  • Ebola virus disease is a rare disease that most commonly affects people and nonhuman primates (such as monkeys, gorillas, and chimpanzees). (cdc.gov)
  • Preclinical research in primates by the VRC and Okairos, a biotechnology company acquired last year by GSK, indicate that the vaccine provides protection in non-human primates exposed to Ebola without significant side effects. (genengnews.com)
  • WINNIPEG, Manitoba and FREDERICK, Md. -- Scientists from the Public Health Agency of Canada (PHAC) -- with assistance from the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) -- have developed vaccines against the Ebola and Marburg viruses that have been shown to be effective in non-human primates. (infectioncontroltoday.com)
  • According to Geisbert, this is the first vaccine system, or platform, that has protected nonhuman primates from both Ebola and Marburg. (infectioncontroltoday.com)
  • We know from previous studies in non-human primates that CD8 T cells played a crucial role in protecting animals that had been vaccinated with this NIAID/GSK vaccine and then exposed to otherwise lethal amounts of Ebola virus," says Julie Ledgerwood, the trial's principal investigator. (facmedicine.com)
  • Therefore, this study designed a novel synthetic anti-Ebola virus glycoprotein DNA vaccine as a strategy to expand protective breadth against diverse Ebola virus strains and evaluated the impact of vaccine dosing and route of administration on protection against lethal Ebola virus-Makona challenge in nonhuman primates. (infectiousdiseaseadvisor.com)
  • Nonhuman primates were challenged on day 20 postimmunization with 1000 50% tissue culture infective dose of Ebola virus/H.sapiens-tc/GIN/2014/Makona-C07. (infectiousdiseaseadvisor.com)
  • A collaborative team from the University of Texas Medical Branch at Galveston and the National Institutes of Health (NIH) have developed an inhalable vaccine that protects primates against Ebola. (globalbiodefense.com)
  • Another Ebola vaccine, developed by NewLink Genetics, is also being tested in a human clinical trial. (livescience.com)
  • V920, Merck's investigational Ebola Zaire vaccine, was initially engineered by scientists from the Public Health Agency of Canada's National Microbiology Laboratory and subsequently licensed to a subsidiary of NewLink Genetics Corporation. (merck.com)
  • It had been used extensively in the Kivu Ebola epidemic under a compassionate use protocol. (wikipedia.org)
  • The company has also asked permission from the World Health Organization (WHO) to use the vaccine if another epidemic arises before the vaccine is licensed, and to make a supply of at least 300,000 doses available by May for such use. (nature.com)
  • Public-health experts fear that as the West Africa epidemic winds down, there is danger that the work of stockpiling, licensing and planning to administer Ebola vaccines will be set aside in favour of more pressing - and profitable - pursuits. (nature.com)
  • But, one could argue that even though Ebola is known to have been around since the 1970s, and may have been around before that (entire villages falling to a deadly disease is known historically in the region, with no understanding of what the disease was), it only arose as an epidemic once, so really, what's the big deal? (scienceblogs.com)
  • Accra, 27 April 2015 - Despite signs of the Ebola Virus Disease (EVD) epidemic abating in West Africa, efforts continue to find an effective vaccine that can fight the virus both now and for future generations. (who.int)
  • If this vaccine is proven to work, it could help alter the dynamic of this epidemic by interrupting transmission to the health care workers who are most at risk," Dr. Myron Levine, director of the Center for Vaccine Development at the University of Maryland School of Medicine, said in the statement . (livescience.com)
  • While these compelling results come too late for those who lost their lives during West Africa's Ebola epidemic, they show that when the next Ebola outbreak hits, we will not be defenseless," said Marie-Paule Kieny, PhD, the World Health Organization's assistant director-general for health systems and innovation and the study's lead author. (beckershospitalreview.com)
  • The Ebola epidemic of 2014 and 2015 was just the latest outbreak of this potentially deadly disease and we cannot predict when or where the next outbreak will occur," explained BARDA acting director Dr. Richard Hatchett. (infectioncontroltoday.com)
  • In 2014 and 2015, the Ebola epidemic in West Africa led to more than 28,000 suspected cases of the illness, more than 15,000 confirmed cases, and 11,310 deaths. (infectioncontroltoday.com)
  • He continued, "With an understanding that vaccines have an important role to play in countering this epidemic threat, we look forward to the EMA's review of our applications for licensure. (pharmatimes.com)
  • The 2013-'16 West Africa Ebola epidemic caused more than 11,000 deaths, but also sparked a funding surge focused on preventing the disease. (vox.com)
  • The report, "Recommendations for Accelerating the Development of Ebola Vaccines," says that all vaccines should be tested in clinical trials, even if an early winner emerges, because more than one kind of vaccine may be needed to quell the current epidemic and to protect at-risk groups against the threat of future outbreaks. (superdoctors.com)
  • It also suggests that if the waning of the epidemic makes it hard to judge the performance of the vaccines, it may be possible to license a vaccine on the basis of animal data and human immune responses. (superdoctors.com)
  • The aim of the effort is to help guide global efforts to expedite the delivery of safe and effective Ebola vaccines both to help stop the current epidemic and to improve preparedness for future Ebola outbreaks. (superdoctors.com)
  • We may see an end to this Ebola epidemic within the year if we continue with the current remarkable efforts, but we must not be complacent about the inevitable future epidemics of Ebola and other emerging infectious diseases. (superdoctors.com)
  • While the West African epidemic is still not over, we have to consider the importance of a vaccine for stopping this epidemic and future ones. (superdoctors.com)
  • Assistant Director-General Marie-Paule Kieny, who leads the Ebola Research and Development effort at WHO, said: "An effective vaccine to control current flare-ups could be the game-changer to finally end this epidemic and an insurance policy for any future ones. (un.org)
  • For the 2013-2016 outbreak in Africa, see Ebola virus epidemic in West Africa . (wikipedia.org)
  • Thomas Eric Duncan was from Monrovia, Liberia , to date the country hit hardest by the Ebola virus epidemic . (wikipedia.org)
  • Ebola virus disease is a rare disease that most commonly been altered to contain a gene from the Ebola virus. (cdc.gov)
  • Outbreaks of Ebola virus disease instead of the whole Ebola virus, it cannot cause Ebola virus occur mostly on the African continent. (cdc.gov)
  • Ebola vaccine is recommended by CDC for adults 18 years are infected with the virus or who have died of Ebola and older at high risk for potential exposure to Ebola virus virus disease. (cdc.gov)
  • Talk with Ebola virus disease is often deadly. (cdc.gov)
  • People who survive Ebola virus disease may have health care provider problems after they recover. (cdc.gov)
  • For such situations, the US Food and Drug Administration (FDA) has established the "animal efficacy rule" allowing licensure to be approved on the basis of animal model studies that replicate human disease, combined with evidence of safety and a potentially potent immune response (antibodies in the blood) from humans given the vaccine. (wikipedia.org)
  • In December 2016, a study found the VSV-EBOV vaccine to be 95-100% effective against the Ebola virus, making it the first proven vaccine against the disease. (wikipedia.org)
  • Outbreaks of Ebola virus disease occur mostly on the African continent. (cdc.gov)
  • Ebola virus spreads through direct contact with the blood, body fluids, and tissues of people or animals who are infected with the virus or who have died of Ebola virus disease. (cdc.gov)
  • There is little risk of catching Ebola virus disease for travelers or the general public who have not cared for or been in close contact with someone infected with Ebola virus. (cdc.gov)
  • Symptoms of Ebola virus disease may appear between 2 to 21 days after contact with the virus. (cdc.gov)
  • Ebola virus disease is often deadly. (cdc.gov)
  • Because the Ebola vaccine only contains a gene from the Ebola virus instead of the whole Ebola virus, it cannot cause Ebola virus disease in the person being vaccinated or in other people who have contact with the person being vaccinated. (cdc.gov)
  • We are in the most tenuous situation with regard to Ebola vaccines that we've seen since we started all of this," says Michael Osterholm, a public-health scientist at the University of Minnesota's Center for Infectious Disease Research and Policy in Minneapolis. (nature.com)
  • However, if it is eventually shown to work and if this information can be generated fast enough, it could become a public health tool to bring the current, and future, Ebola virus disease epidemics under control," Dr. Sow added. (genengnews.com)
  • Ordinarily, CVD said, it takes between six to 11 months to advance a vaccine from animal-model research to to a clinical trial in a developing country where subjects are at risk of the natural disease. (genengnews.com)
  • We don't know if the vaccines are going to work, and how well, and what the side effects will be, but we will get some information as we get into the New Year," said Dr. William Schaffner, an infectious-disease specialist at Vanderbilt Medical Center in Nashville, Tennessee, who is not involved with the trials. (livescience.com)
  • Reports released last week by the Centers for Disease Control and Prevention (CDC) suggested the number of new Ebola cases is now declining in two of Liberia's 15 counties. (livescience.com)
  • Three vaccine regimens for Zaire Ebola virus disease (EVD) produced antibody responses in adults and children, according to the results of two randomized trials conducted in West Africa. (medpagetoday.com)
  • Although these results add to the evidence for immunogenicity and safety of the Ad26-MVA regimen and the rVSVΔG-ZEBOVGP vaccine in adults and children, "there is no universally agreed-on correlate of protective immunity to EVD, and in this trial we were unable to assess protection from disease given that there were no incident cases of EVD," the team wrote. (medpagetoday.com)
  • The Centers for Disease Control and Prevention (CDC) recently determined that the Ebola virus can be found in semen for a year or longer after a person has recovered from the illness. (infectioncontroltoday.com)
  • I think it is very encouraging to see these very positive, preliminary results of this vaccine trial from Guinea," says Dr. Jesse Goodman , an infectious disease specialist at Georgetown University, who once led vaccine development at the U.S. Food and Drug Administration. (wgbh.org)
  • Prime-boost vaccine regimens involve an initial dose that primes the immune system to develop disease-specific antibodies, followed by a booster dose at a later date that can strengthen and optimize the duration of the immune response. (jnj.com)
  • There are five species of Ebola, four of which have caused the disease in humans: Zaire, Sudan, Taï Forest, and Bundibugyo. (vox.com)
  • The Ebola virus disease is caused by one of six species of ebolaviruses, four of which are known to cause disease in humans. (staradvertiser.com)
  • Thus, there are currently no licensed vaccines for the Sudan virus disease, considered a severe, often fatal illness. (staradvertiser.com)
  • In a development that could change the way the deadly Ebola disease is fought, researchers have announced promising results of a new vaccine's trial in Guinea, one of several countries affected by a historic outbreak in West Africa. (wuft.org)
  • Even if the sample size is quite small and more research and analysis is needed," Draguez says, "the enormity of the public health emergency should lead us to continue using this vaccine right now to protect those who might get exposed to the disease: contacts of infected patients and front-line workers. (wuft.org)
  • So a vaccine is really to prevent disease - or at least to lessen the burden of a disease. (theworld.org)
  • and the Centers for Disease Control and Prevention's (CDC) Ebola vaccine information statement . (msdmanuals.com)
  • This vaccine is also stockpiled in Switzerland for rapid distribution to people in regions where an outbreak of Ebola virus disease is occurring. (msdmanuals.com)
  • WHO, the UN Children's Fund ( UNICEF ), the U.S. Centers for Disease Control (CDC), the Bill and Melinda Gates Foundation and vaccine alliance GAVI are collaborating with the affected countries to develop plans and strategies for large-scale introduction, should this be needed. (un.org)
  • Since the current outbreak of Ebola emerged in August 2018, nearly 400 CDC volunteers have deployed to the Democratic Republic of Congo (DRC), neighboring countries, and Geneva to help fight the disease. (cdc.gov)
  • 1 Ebola Virus Disease Outbreak: overview of needs and requirements, United Nations, September 2014. (who.int)
  • Ebola virus disease in the U.S. (wikipedia.org)
  • Four laboratory-confirmed cases of Ebola virus disease (commonly known as "Ebola") occurred in the United States in 2014. (wikipedia.org)
  • On September 30, 2014, the Centers for Disease Control and Prevention (CDC) announced that Thomas Eric Duncan , a 45-year-old Liberian national visiting the United States from Liberia , had been diagnosed with Ebola in Dallas, Texas . (wikipedia.org)
  • On September 15, 2014, the family of Marthalene Williams, who later died of Ebola virus disease , could not call an ambulance to transfer the pregnant Williams to a hospital. (wikipedia.org)
  • Although there have been significant breakthroughs in the Ebola virus disease vaccine development field, there remains an important need for prophylactic anti-Ebola virus vaccine candidates that elicit long-lasting immune responses. (infectiousdiseaseadvisor.com)
  • As of September 17, 2019, an active outbreak of Ebola virus disease in the Democratic Republic of the Congo (DRC) had resulted in 3,034 confirmed and 111 probable cases of Ebola virus disease, including 2,103 attributable deaths. (medscape.com)
  • Mike Miller] Dr. MacNeil, Ebola is probably the most terrifying disease that people know about. (cdc.gov)
  • Ebola hemorrhagic fever, or EHF, and is a disease caused by a group of viruses known as Ebola viruses. (cdc.gov)
  • However, no additional cases of Ebola hemorrhagic fever occurred and the disease was diagnosed by a laboratory within Uganda. (cdc.gov)
  • This was the first known occurrence of Ebola hemorrhagic fever in Uganda since 2007 and the first time the disease was ever diagnosed at a laboratory within the country. (cdc.gov)
  • Is there a vaccine for this disease? (cdc.gov)
  • Although a number of other febrile viral infections may produce hemorrhage, only the agents of Lassa, Marburg, Ebola, and Crimean-Congo hemorrhagic fevers are known to have caused significant outbreaks of disease with person-to-person transmission. (cdc.gov)
  • Learn more about Ebola disease. (cdc.gov)
  • The U.S. Food and Drug Administration (FDA) has approved the Ebola vaccine, ERVEBO ® , for the prevention of Ebola disease. (cdc.gov)
  • CDC in collaboration with the Johns Hopkins Applied Physics Laboratory designed the app for field staff with variable levels of education and knowledge of the natural disease progression of Ebola. (cdc.gov)
  • New vaccines continue to push back the frontiers of disease. (bvsalud.org)
  • Ebola virus disease contact tracing activities, lessons learned and best practices during the Duport Road outbreak in Monrovia, Liberia, November 2015. (cdc.gov)
  • BACKGROUND: Contact tracing is one of the key response activities necessary for halting Ebola Virus Disease (EVD) transmission. (cdc.gov)
  • We wanted to make sure there was vaccine that was prepared and ready to be used if there was a potential outbreak," says Seth Berkley, chief executive of Gavi in Geneva, Switzerland. (nature.com)
  • German-based Secop GmbH, a manufacturer of medical refrigeration compressors and the largest compressor supplier to the Global Alliance for Vaccines and Immunization (GAVI), introduces MP2UVULTM, a compressor designed for mobile refrigeration systems that require extreme low temperatures to safely transport biomaterials such as CGTs (Cell and Gene Therapies) and mRNA-based vaccines for COVID-19 and Ebola. (natda.org)
  • The GAVI Alliance has relied on Secop products for many years to support its mission to improve access to life-saving vaccines in developing countries. (natda.org)
  • The press conference will include two special guests today and those are Henrietta Fore, UNICEF Director, and Dr Seth Berkley, CEO of GAVI, the vaccine alliance. (bvsalud.org)
  • A portion of the rejoinder explaining the real facts on the issue read: "In December 2018, the International Rescue Committee, IRC conducted an assessment to examine the effect of the ongoing Ebola outbreak and response on women and girls. (africanews.com)
  • A recent increase in funding for Ebola vaccine research is also enabling GSK to begin manufacturing at least 10,000 additional doses of the vaccine, even as the first clinical trials are occurring. (genengnews.com)
  • As the deadly Ebola virus rises again in central Africa, health officials have decided to try a different approach to fight back -- rushing more than 7,500 doses of an experimental Ebola vaccine to the Democratic Republic of Congo. (go.com)
  • While the vaccine has not yet earned approval from any regulatory body, an emergency stockpile of 300,000 doses has been created to quell an outbreak should one flare up. (beckershospitalreview.com)
  • GENEVA (AP) - The head of the World Health Organization said Wednesday that he expects the first doses of Ebola vaccine targeting the strain behind an outbreak in Uganda to arrive in the country next week. (ktar.com)
  • We expect the first doses of vaccine to be shipped to Uganda next week," Tedros said, adding that officials have now confirmed 141 cases, including 55 deaths, in the current outbreak, which is the first of the Sudan strain of Ebola in Uganda in more than 10 years. (ktar.com)
  • More than 680 doses of an Ebola vaccine have been given out in the Democratic Republic of Congo, where an outbreak of the deadly virus is ongoing. (vox.com)
  • Merck's rVSV-ZEBOV is the first highly effective Ebola vaccine , and the 7,500 doses that have been sent to the DRC are expected to be an extremely useful tool in the outbreak , which so far involves 50 cases and 25 deaths . (vox.com)
  • Criteria included acceptable safety profile, induction of appropriate immune responses, including neutralizing antibodies, and the timely availability of sufficient supplies of vaccine doses. (un.org)
  • Johnson & Johnson JNJ ("J&J") announced that the European Commission (EC) has granted marketing approval to its two-dose Ebola vaccine regimen for the prevention of Ebola Virus caused by Zaire strain. (nasdaq.com)
  • The MAAs were supported by data from eleven phase I, II and III studies evaluating the safety and immunogenicity of the vaccine regimen. (nasdaq.com)
  • The European approval of theEbola vaccine regimen marks the first major regulatory approval of a vaccine developed by Janssen. (nasdaq.com)
  • The Ebola vaccine regimen leverages Janssen's AdVac technologyplus Bavarian Nordic's established MVA-BN technology. (nasdaq.com)
  • The Ebola vaccine regimen in development at the Janssen Pharmaceutical Companies of Johnson & Johnson, which was discovered in a collaborative research program with the National Institutes of Health, uses a prime-boost combination of two components that are based on AdVac® technology from Crucell Holland B.V., one of the Janssen Pharmaceutical Companies, and the MVA-BN® technology from Bavarian Nordic. (who.int)
  • The company is collaborating with numerous partners, including London School of Hygiene and Tropical Medicine and Inserm, to accelerate the development of the vaccine regimen. (who.int)
  • Evaluation of the vaccine regimen commenced with Phase I clinical trial at the Oxford Vaccine Group in December 2014 and this has been followed by Phase 1 studies in the United States (US) and Africa (Kenya, Uganda, Tanzania). (who.int)
  • Johnson & Johnson has announced the submission of Marketing Authorisation Applications (MAAs) to the European Medicines Agency (EMA) for its investigational Ebola vaccine regimen. (pharmatimes.com)
  • The company confirmed that two MAAs have been submitted in parallel supporting each vaccine in the two-dose regimen (Ad26.ZEBOV, MVA-BN-Filo), on the back of a decision from the EMA's Committee for Medicinal Products for Human Use (CHMP) to grant an Accelerated Assessment for the applications in September. (pharmatimes.com)
  • The MAAs are supported by data from Phase I, II and III clinical studies evaluating the safety and immunogenicity of the vaccine regimen in adults and children, and data pooled from more than 6,500 volunteers across the U.S., Europe and Africa over 10 clinical studies. (pharmatimes.com)
  • Currently, the company is also in discussions with the US Food and Drug Administration (FDA) to define the required data set for filing of the Janssen Ebola vaccine regimen under the FDA's Animal Rule licensure pathway. (pharmatimes.com)
  • NEW BRUNSWICK, N.J., - September 14, 2015 - Johnson & Johnson (NYSE: JNJ) announced today that Crucell Holland B.V., one of its Janssen Pharmaceutical Companies, has been awarded $28.5 million from The Biomedical Advanced Research and Development Authority (BARDA), part of the U.S. Department of Health and Human Services, to help accelerate the development of its investigational Ebola prime-boost vaccine regimen. (jnj.com)
  • The agreement involves a 5-year commitment, with options for an additional $40.5 million funding, to optimize manufacturing systems and capacity for the vaccine regimen, including technology transfers to large-scale production facilities, heat-stability studies to verify that the regimen is optimized for use in African countries, and final product manufacturing and quality control activities. (jnj.com)
  • Phase I clinical studies of the prime-boost vaccine regimen began in the United Kingdom and United States in December 2014, followed by several sites in Africa. (jnj.com)
  • Janssen, in partnership with Bavarian Nordic, has produced drug supply for more than 800,000 regimens and is set-up to be able to produce a total of 2 million regimens of the Ebola vaccine regimen during the course of 2015. (jnj.com)
  • The study involves a prime-boost vaccine regimen followed by a boost intended to further enhance the level of the body's immune response over time. (pharmexec.com)
  • A booster dose of Ebola vaccine is available for people at least 6 months after the single dose under an expanded access Investigational New Drug (IND) program. (cdc.gov)
  • We continue to be proud and humbled to provide our investigational V920 Ebola vaccine as an additional tool in support of the comprehensive public health response efforts against the current Ebola outbreak. (merck.com)
  • In the VSV-EBOV investigational vaccine, the gene for the outer protein of VSV replaces the same gene segment of the Zaire Ebola virus species. (wuft.org)
  • The vaccine was proven safe at multiple sites in North America, Europe, and Africa, but several volunteers at one trial site in Geneva, Switzerland, developed vaccine-related arthritis after about two weeks, and about 20-30% of volunteers at reporting sites developed low-grade post-vaccine fever, which resolved within a day or two. (wikipedia.org)
  • Much of the devastation wrought by Ebola in West Africa might have been prevented with a vaccine. (nature.com)
  • With the Ebola outbreak in West Africa stubbornly hanging on, officials have brokered an agreement to ensure that a vaccine is available to fight future occurrences. (nature.com)
  • The recurrence of Ebola in Sierra Leone on 15 January - just one day after the WHO had declared that spread of the virus had stopped in West Africa - highlights the need for an Ebola vaccine stockpile, Berkley says. (nature.com)
  • With Ebola still tearing through West Africa, surely the last thing anyone wants to hear about it are setbacks in the search for a vaccine. (thedailybeast.com)
  • This research will give us crucial information about whether the vaccine is safe, well tolerated and capable of stimulating adequate immune responses in the highest priority target population, health care workers in West Africa," CVD's director, Myron M. Levine, M.D., D.T.P.H., said in a statement. (genengnews.com)
  • The clinical trial in Mali follows two months of work by an international consortium dedicated to advancing the vaccine into human clinical studies in West Africa. (genengnews.com)
  • West Africa may even reach 1,000 deaths from Ebola this weekend. (planetsave.com)
  • Janssen is also collaborating with the World Health Organization on vaccine pre-qualification to accelerate theregistration of its treatment in Africa. (nasdaq.com)
  • WHO Coordinator of Regulatory System Strengthening, Director of Essential Medicines and Health Products (EMP) Department, Mr. Michael Ward explains the partnership with AVAREF, "WHO plays a key enabling role in supporting the AVAREF network, so that it may fulfil its potential in accelerating the availability of preventative vaccines and other important therapies for the people of Africa. (who.int)
  • No cases of Ebola remain in the United States at the moment, but researchers are busy working on vaccines as the virus continues to spread in West Africa. (livescience.com)
  • A new experimental Ebola vaccine displayed 100 percent efficacy in a clinical trial involving thousands in Guinea, Africa, according to a new study published in The Lancet . (beckershospitalreview.com)
  • The Zaire strain of Ebola has caused repeated outbreaks in Congo in recent years and also triggered the disastrous West Africa outbreak in 2014 that killed more than 11,000 people. (ktar.com)
  • The 2014-16 Ebola outbreak in West Africa highlighted the need for an effective treatment or vaccine. (nih.gov)
  • The most recent case of Ebola occurred in West Africa in April of 2016. (infectioncontroltoday.com)
  • The NIH chief and others have called on lawmakers to pass emergency funding to address the Ebola outbreak in West Africa. (thefiscaltimes.com)
  • Croyle believes the spray is stable at room temperature, an important factor in using the vaccine in hot, humid conditions of Africa where the current outbreak has already killed over 5,000 . (ibtimes.co.uk)
  • The Ebola outbreak in West Africa has put the health care systems of Liberia, Sierra Leone and Guinea under tremendous pressure. (jnj.com)
  • During the West Africa outbreak, researchers - from the World Health Organization, Guinea's Ministry of Health, Public Health England, and other international partners - worked together to help set up a clinical trial to test the vaccine. (vox.com)
  • A team of health experts concerned about the long-term threat of Ebola released today a lengthy set of recommendations for the development of Ebola vaccines, saying that the push to test vaccines in West Africa must continue even if fading cases make it difficult to tell for certain if the inoculations are working. (superdoctors.com)
  • Michael T. Osterholm, PhD, MPH, director of CIDRAP, observed that in the context of declining Ebola cases in West Africa, the main message of the report is that "having an evaluation of the effectiveness, safety, and community acceptance of Ebola vaccines is still very critical to a long-term strategy for controlling Ebola in Africa. (superdoctors.com)
  • The report says there is a real possibility that Ebola will become endemic in West Africa, creating a risk of ongoing, sporadic local flare-ups. (superdoctors.com)
  • The Ebola virus was first identified in 1976 and caused sporadic outbreaks in Africa. (un.org)
  • However, the 2013-2016 outbreak in west Africa, that killed more than 11,300 people, underlined the urgent need of a vaccine. (un.org)
  • The announcement came as the agency, in its latest update on Ebola, reported 132 new confirmed cases had been reported in West Africa in the week to 1 March, an increase from the previous week of 99 new cases. (un.org)
  • Since September 2014, according to WHO, the two most advanced Ebola vaccines have been evaluated in about 15 countries in Africa, Europe and North America. (un.org)
  • One scenario that people worried about tremendously was Nigeria-not only having the mega-city of Lagos, but in the north of Nigeria having insecure conditions with an Islamic insurgency that might well have prevented international health responders from accessing those who needed care, which could have resulted in Ebola becoming endemic in Africa. (technologyreview.com)
  • Mike Miller] Now, Ebola virus is mostly found in Africa, right? (cdc.gov)
  • Adam MacNeil] All known cases of Ebola hemorrhagic fever in humans have occurred in Africa. (cdc.gov)
  • Lassa, Marburg, and Ebola viruses are restricted to sub-Saharan Africa, and the differential diagnosis of VHF will most often be made for illness in travelers to this region. (cdc.gov)
  • The recent Ebola outbreak in West Africa provided an opportunity for researchers to test the two experimental vaccines for safety and effectiveness. (medlineplus.gov)
  • The vaccine contains a weakened strain of the vesicular stomatitis virus that has been altered to contain a gene from the Ebola virus. (cdc.gov)
  • The vaccine contains a cold virus that infects chimpanzees, along with a single gene from the Ebola virus, which the researchers hope will prompt the body to develop an immune response to Ebola. (livescience.com)
  • Clinical trials involve the administration of the vaccine to healthy human subjects to evaluate the immune response, identify any side effects and determine the appropriate dosage. (wikipedia.org)
  • Sierra Leone and Guinea have made arrangements with the relevant companies to use the vaccines in clinical trials. (nature.com)
  • I think the other thing to keep in mind here is…that these clinical trials are done blinded," meaning that there are some people will get the vaccine and others will not, but those who receive the placebo are under the impression they are receiving the experimental substance. (thedailybeast.com)
  • This is just the critical first step in a series of additional clinical trials that will have to be carried out to fully evaluate the promising vaccine," said Samba Sow, M.D., Director General of CVD-Mali, in a joint statement issued today by the trial partners. (genengnews.com)
  • The next stage would be clinical trials to test the effectiveness of the vaccine in human subjects. (ibtimes.co.uk)
  • The tragedy got the public and private sector galvanized around pushing an Ebola vaccine candidate through the clinical trials process . (vox.com)
  • Having multiple vaccines progressing through clinical trials increases the likelihood of vaccine manufacturers having the capacity to meet production demands should mass immunisation be required. (pharmexec.com)
  • And we are also supporting two other vaccines - both of which, actually, we're hoping to see entering already clinical studies - phase one clinical trials - in June. (theworld.org)
  • Based on promising data from initial clinical trials in late 2014, WHO said it will launch a Phase III trial in Guinea on 7 March to test the so-called VSV-EBOV vaccine for efficacy and effectiveness to prevent Ebola in collaboration with the Health Ministry of Guinea, Médecins Sans Frontières (MSF), Epicentre and the Norwegian Institute of Public Health. (un.org)
  • two vaccines are in clinical trials, with preliminary safety and immunogenicity data due by end-January 2015. (who.int)
  • VSV-EBOV or rVSV-ZEBOV, sold under the brand name Ervebo, is a vaccine based on the vesicular stomatitis virus which was genetically modified to express a surface glycoprotein of Zaire Ebola virus. (wikipedia.org)
  • The Public Health Agency of Canada (PHAC) says the single-dose Ervebo vaccine should be offered to persons who have been exposed to the Ebola virus in Canada. (cp24.com)
  • The approval of the vaccine is a landmark moment for the company as it brings forth a vaccine to treat the deadly Ebola virus. (nasdaq.com)
  • In an interview with the Huffington Post, Collins said NIH had been working on a vaccine for the deadly virus since at least 2001, but constant budget cuts had slowed down the process by one or two years. (thefiscaltimes.com)
  • TORONTO -- Earlier this week, U.S. President Barack Obama signed into law a little piece of legislation that may significantly change the economics of making drugs or vaccines to protect against Ebola and other viruses in its deadly family. (cp24.com)
  • But it doesn't actually contain deadly Ebola virus - it works by replacing a gene from a harmless livestock virus , vesicular stomatitis, with a gene encoding an Ebola virus surface protein to trick the body's immune system. (vox.com)
  • The United Nations World Health Organization (WHO) has said that an experimental Ebola vaccine has been found to be highly protective against the deadly virus in a major trial in Guinea. (un.org)
  • That means about 228 million children are vulnerable right now to deadly vaccine-preventable diseases such as measles, yellow fever and polio. (bvsalud.org)
  • Researchers have successfully tested two vaccines that appear to help block the deadly Ebola virus in humans. (medlineplus.gov)
  • At least 26 deaths have been tied to the current outbreak of Ebola virus in the Democratic Republic of the Congo's Bikoro Health Zone, Equateur Province, according to the World Health Organization. (go.com)
  • We need to act fast to stop the spread of Ebola by protecting people at risk of being infected with the Ebola virus, identifying and ending all transmission chains and ensuring that all patients have rapid access to safe, high-quality care,' Dr. Peter Salama, deputy director-general for emergency preparedness and response at the World Health Organization said. (go.com)
  • Other treatments, including plasma from people who have recovered from Ebola, and the experimental drug ZMapp , are slated for testing by the end of 2014, the World Health Organization (WHO) said in a recent report . (livescience.com)
  • It is a game changer because there was nothing that could protect people against Ebola - no drug, vaccine or medicine," says Dr. Marie-Paule Kieny , assistant director-general for health systems and innovation at the World Health Organization, who helped to lead the trial. (wgbh.org)
  • The group of authors calls itself "Team B" in recognition of the primary role of the World Health Organization (WHO) and national governments in leading the Ebola response. (superdoctors.com)
  • The World Health Organization, meanwhile, is working urgently to support the Ugandan government in its response to the Ebola outbreak, which health authorities declared on Sept. 20. (staradvertiser.com)
  • Scientists at the National Microbiology Lab in Winnipeg, Manitoba, prepare an experimental Ebola vaccine for shipment to the World Health Organization (WHO) in Geneva in this undated handout picture released October 18, 2014. (theworld.org)
  • GeoVax has demonstrated that a single intramuscular (IM) dose of its vaccine candidate, GEO-EM01, provided 100% protection in rhesus macaques challenged with a lethal dose of Ebola virus (EBOV). (gabio.org)
  • In addition to its vaccine for EBOV, GeoVax is also developing preventive vaccines for other hemorrhagic fever viruses highly lethal to humans. (gabio.org)
  • David Dodd, GeoVax President and CEO, commented, "While our corporate focus and development priorities continue to be our COVID-19 vaccine and cancer immunotherapy programs, developing vaccines against lethal hemorrhagic fever viruses is also of interest and under consideration as part of our longer-term focus. (gabio.org)
  • The scientists state that the macaques received the vaccine through a nebuliser, and then injected with a lethal dose of the Ebola virus - and not only were there no adverse reactions to the vaccine, but every macaque was perfectly healthy after the Ebola virus injection, too. (webworldtoday.com)
  • Results showed that multiple-injection regimens of the anti-Ebola virus glycoprotein DNA vaccine delivered by intramuscular administration followed by electroporation were 100% protective against the lethal Ebola virus-Makona challenge. (infectiousdiseaseadvisor.com)
  • Of note, when the anti-Ebola virus glycoprotein DNA vaccine was by 2 injections delivered intradermally followed by electroporation, a strong immunogenicity was generated and was also 100% protective against the lethal Ebola virus-Makona challenge. (infectiousdiseaseadvisor.com)
  • If somebody were to come down with Ebola or another highly lethal pathogen, they wouldn't be more than two hours away from a hospital that was designed to treat them. (technologyreview.com)
  • While an effective Ebola vaccine against the Zaire strain exists, the Sudan strain is less common, and research into a possible vaccine against it has not been as advanced. (ktar.com)
  • A single-dose aerosol vaccine would enable both prevention and containment of Ebola infections, in a natural outbreak setting where healthcare infrastructure is lacking or during bioterrorism and biological warfare scenarios. (globalbiodefense.com)
  • Under the collaboration, GeoVax's SUDV and MARV vaccine candidates are being tested for immunogenicity and efficacy in the benchmark nonhuman primate model. (gabio.org)
  • The estimated vaccine efficacy was 100 percent," a team of researchers say. (wuft.org)
  • No specific therapy is available that has demonstrated efficacy in the treatment of Ebola hemorrhagic fever. (medscape.com)
  • Yet 15-20% of these contacts developed immune responses capable of neutralizing Ebola viruses, suggesting that they had contracted mild infections that went undetected. (scienceblogs.com)
  • The meeting aimed to review the scientific and ethical aspects of the proposed vaccine trial in Sierra Leone to evaluate the immune response, identify any side effects and determine its effectiveness. (who.int)
  • Doctors are monitoring the immune systems of about 40 people to see how they react to an Ebola protein in the vaccine, the company said in a statement . (livescience.com)
  • Immune responses were elicited by 14 days after injection for these vaccine regimens and were maintained for 12 months," the authors wrote in the New England Journal of Medicine . (medpagetoday.com)
  • The contract could be extended for up to a total of five years and $75.98 million to support additional safety studies and analyses of how well the vaccine stimulates the human immune system when produced at commercial scale. (infectioncontroltoday.com)
  • The MVA-VLP derived vaccines can elicit durable immune responses in the host similar to a live-attenuated virus, while providing the safety characteristics of a replication-defective vector. (gabio.org)
  • Researchers from the National Institutes of Health found that the vaccine induced a strong immune response in all twenty people who received it and led to the production of certain immune cells thought to be key in protecting against Ebola. (facmedicine.com)
  • In addition, there is a need for a preventive vaccine that is deliverable to highly vulnerable populations that include children, immune-compromised individuals, and pregnant women. (infectiousdiseaseadvisor.com)
  • Ebola monoclonal antibodies may interfere with immune response of live vaccines. (medscape.com)
  • The first vaccine to be approved in the United States was rVSV-ZEBOV in December 2019. (wikipedia.org)
  • The Guardian article titled 'Ebola vaccine offered in exchange for sex, Congo taskforce meeting told,' was published on Tuesday 12th February 2019. (africanews.com)
  • CDC's Rosalind Carter, right, and a Ugandan colleague prepare to give the Ebola vaccine to health workers in northwestern Uganda in July 2019. (cdc.gov)
  • Ebola virus is one of at least 30 known viruses capable of causing viral hemorrhagic fever syndrome. (medscape.com)
  • Aerosolized delivery has never before been tested for an Ebola vaccine or any other viral hemorrhagic fever vaccine. (globalbiodefense.com)
  • Adam MacNeil] This is a single case of Ebola hemorrhagic fever, which occurred in a school-age child in Uganda in May of 2011. (cdc.gov)
  • Interestingly, this is one of the few instances in which we've identified a single case of Ebola hemorrhagic fever in an outbreak. (cdc.gov)
  • ATLANTA, GA, October 14, 2021 - GeoVax Labs, Inc . (Nasdaq: GOVX), a biotechnology company developing human immunotherapies and vaccines against infectious diseases and cancer, today announced that the U.S. Patent and Trademark Office has issued a Notice of Allowance for Patent Application No. 15/543,139 entitled "Replication-Deficient Modified Vaccinia Ankara (MVA) Expressing Ebola Virus Glycoprotein (GP) and Matrix Protein (VP40) . (gabio.org)
  • These antibodies target the glycoprotein (GP) on the Ebola virus surface, thereby blocking attachment and entry of the virus on host cell membranes. (medscape.com)
  • In addition, the vaccine targets dendritic cells, which are the same cells that Ebola and Marburg attack, says Geisbert. (infectioncontroltoday.com)
  • The study describes how Canadian researchers developed the vaccines by replacing a surface protein in an animal pathogen, called vesicular stomatitis virus, with a surface protein from either the Ebola or Marburg viruses. (infectioncontroltoday.com)
  • PHACs National Microbiology Laboratory is Canadas only Containment Level 4 laboratory, where pathogens such as Ebola and Marburg can be worked with safely. (infectioncontroltoday.com)
  • Separately, GeoVax is leading a multi-party collaboration for the development of its SUDV and Marburg virus (MARV) vaccine candidates. (gabio.org)
  • Ebola Virus and Marburg Virus Infections Marburg and Ebola virus infections cause bleeding and organ malfunction. (msdmanuals.com)
  • Marburg and Ebola infections are spread through handling live or dead infected. (msdmanuals.com)
  • A person can only spread Ebola virus to other people after designated special pathogen treatment centers in the they develop symptoms. (cdc.gov)
  • We also established a network of Ebola treatment centers: 35 hospitals across the United States, plus a number of labs that were designated by the federal government. (technologyreview.com)
  • Minister Bennett added that people everywhere could benefit from the vaccine development, in stopping outbreaks where they originate as well as reducing the risk that these viruses will spread. (infectioncontroltoday.com)
  • The findings will help inform the development of potential treatments and vaccines for Ebola and related viruses. (nih.gov)
  • There are some types of Ebola virus and closely related viruses found in other parts of the world. (cdc.gov)
  • Adam MacNeil] It is possible for Ebola viruses to be transmitted from one person to another person. (cdc.gov)
  • Researchers will soon publish the first confirmed report of a person without obvious Ebola symptoms infecting another person. (scienceblogs.com)
  • Researchers must show sensitivity in communicating such findings, says virologist Stephan Günther of the Bernhard Nocht Institute, and take care not to make life more difficult than it already is for Ebola survivors, who face discrimination and lingering health problems. (scienceblogs.com)
  • An increase in Ebola treatment units, safe burials and public education may have helped stem the virus' spread in these counties, researchers said. (livescience.com)
  • The researchers used the PREVAC protocol, which compared the three vaccine regimens with placebo in adults and children separately. (medpagetoday.com)
  • To conduct the Guinea trial, researchers used newly confirmed Ebola cases to identify clusters of people with whom the patients had contact. (wuft.org)
  • The researchers who ran the trial say their results suggest a single injection is highly effective, and that protection against Ebola can be established quickly. (wuft.org)
  • However a number of researchers are working on vaccines and there are a number of promising candidates that are being developed. (cdc.gov)
  • The name Ebola is actually the name of a river found in the Democratic Republic of Congo near where some of the first cases were identified. (cdc.gov)
  • The results suggesting that V920 protected against Ebola virus infections in humans were published in July 2015. (infectioncontroltoday.com)
  • Under the previous ASPR contract, BPS developed a process to scale up manufacturing of V920 to produce large quantities of the vaccine. (infectioncontroltoday.com)
  • The FDA has accepted an application for approval of Merck's Ebola vaccine V920. (fiercebiotech.com)
  • It is simply NOT the case that thousands of post pandemic West Africans are restarting ebola epidemics wherever they go. (scienceblogs.com)
  • We can prevent future epidemics by acting quickly and decisively to complete development of Ebola vaccines and treatments for use worldwide. (infectioncontroltoday.com)
  • Kobinger was a key scientist leading the creation of an Ebola vaccine and has successfully worked to fight other epidemics, including the Zika virus. (theworld.org)
  • But Ebola taught us that there's an incredible penalty for inaction, because epidemics grow exponentially: every day you delay responding, you end up facing a steeper exponential curve that makes the situation quickly transition from what would have been manageable to something that's unmanageable. (technologyreview.com)
  • In the coming weeks, 37 more health care workers will receive the vaccine, according to CVD. (genengnews.com)
  • AVAREF Chair Dr Beno Yakubu said, "Under the platform of AVAREF, this meeting is an indication of the due diligence taken by the pharmaceutical companies and partners to jointly ensure that the clinical trial process is of the highest ethical and scientific standards to ensure the safety of the volunteers and patients who will ultimately receive the vaccine. (who.int)
  • These "rings" were randomized to receive the vaccine either immediately or after a three-week delay. (un.org)
  • The randomization phase of the trial was stopped this week, WHO says, "to allow for all people at risk to receive the vaccine immediately. (wuft.org)
  • So far, data is showing promising results, indicating that the vaccine will likely move into a Phase II trial, they said, which would continue to evaluate the vaccine's safety as well as look at its effectiveness. (livescience.com)
  • Draguez and other experts are heartened by the new results - but they also warn that as testing expands, the effectiveness rate of the vaccine will likely fall below 100 percent. (wuft.org)
  • Recently, a team of scientists from the University of Texas and the U.S. National Institutes of Health came together to create an Ebola vaccine that can be inhaled via an aerosol device or nebuliser, thus eliminating the needle without sacrificing the effectiveness of the vaccine. (webworldtoday.com)
  • Humans are not really a reservoir, long term, for ebola. (scienceblogs.com)
  • It consists of an adenovirus that was modified to prevent multiplication in humans, and which produces a single attachment protein of Ebola virus. (genengnews.com)
  • Demonstrating that these vaccines are safe and effective in monkeys is a promising indicator of their real potential for use in humans. (infectioncontroltoday.com)
  • Although transmission of Ebola virus to humans is not fully understood, it is thought to occur by exposure to infected animals and spread human-to-human from direct contact with blood or other bodily fluids, as well as indirect contact with environments contaminated by these fluids. (medpagetoday.com)
  • Antibodies from an Ebola survivor protected mice and ferrets against all three ebolaviruses that cause outbreaks in humans. (nih.gov)
  • The rVSV-ZEBOV was designed to protect against Zaire, the type of Ebola to most commonly affect humans . (vox.com)
  • No vaccine is expected to be ready for use until at least 2021, as any potential vaccine must be widely tested in humans before being administered to hundreds of millions, if not billions, of people. (theworld.org)
  • Adam MacNeil] Well, Ebola virus is a zoonotic virus, meaning that it lives in nature in animals other than humans. (cdc.gov)
  • Investigators at the Vaccine Research Center (VRC) of NIH's National Institute of Allergy and Infectious Diseases (NIAID) developed the vaccine, called cAd3. (genengnews.com)
  • We note that Bavarian Nordic is a biotechnology company specializing in research, development and manufacture of active cancer immunotherapies and vaccines for infectious diseases. (nasdaq.com)
  • The goal is to evaluate the different dosing levels of the vaccine, which was developed by the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases. (hcplive.com)
  • University of Maryland School of Medicine has an international reputation for creating and testing vaccines, including vaccines for cholera, typhoid, non-typhoid salmonella, dysentery and many other diseases. (hcplive.com)
  • The global community pours more money into fighting baldness and erectile dysfunction than developing treatments or vaccines for "neglected tropical diseases" like Ebola that affect more than a billion of the world's poorest people. (vox.com)
  • GeoVax Labs, Inc. is a clinical-stage biotechnology company developing human vaccines against infectious diseases and cancer using novel patented platforms. (gabio.org)
  • The vaccine candidates also have gotten the attention of the Biomedical Advanced Research and Development Authority, or BARDA, an arm of the U.S. Department of Health and Human Services that invests in medical countermeasures against emerging infectious diseases. (staradvertiser.com)
  • Gary, you pioneered vaccines and treatments for Ebola, for Zika, other diseases as well. (theworld.org)
  • Our conversation is based on his case study of an Ebola virus outbreak in Uganda, which appears in CDC's journal, Emerging Infectious Diseases . (cdc.gov)
  • Thanks to vaccines smallpox is now in the history books, polio has been pushed to the brink of eradication and once-feared diseases like diphtheria, tetanus and meningitis are now easily prevented. (bvsalud.org)
  • As for the outbreak itself, the virus continues to spread in Sierra Leone and Guinea, which had 1,166 and 1,187 deaths from Ebola as of Nov. 14, respectively, according to the CDC. (livescience.com)
  • Five children died, with all deaths unrelated to the vaccine or placebo. (medpagetoday.com)
  • Officials have confirmed at least 130 Ebola cases and more than 40 deaths. (staradvertiser.com)
  • On 31 July 2015, preliminary results of a Phase III trial in Guinea indicated that the vaccine appeared to be "highly efficacious and safe. (wikipedia.org)
  • tracked 80 people who had contact with Ebola patients in Guinea but did not themselves become noticeably ill. (scienceblogs.com)
  • More than 3,500 people were vaccinated with VSV in 2015, as part of a large trial at the end of Ebola outbreak in Guinea . (go.com)
  • In fact, there are so few cases in Guinea right now that Kieny and her team couldn't use the standard method for testing a vaccine. (wgbh.org)
  • Ebola vaccine team at work in Katongourou, Guinea. (un.org)
  • According to WHO, the vaccine, rVSV-ZEBOV was studied in a trial involving 11,841 people in Guinea during 2015. (un.org)
  • A team of contact tracers visited a community in Conakry, Guinea, in 2015 after a family member was infected with Ebola. (un.org)
  • The trial took place in the coastal region of Basse-Guinée, the area of Guinea still experiencing new Ebola cases when the trial started in 2015. (un.org)
  • The current data basically tells us that the vaccine works to protect people against Ebola," says Dr. Bertrand Draguez, medical director of Médecins Sans Frontières, which took part in the research along with WHO and authorities in Guinea. (wuft.org)
  • The first person to receive the trial vaccine in Guinea was Mohamed Soumah, 27. (wuft.org)
  • The interim findings on the Guinea trial are the latest to bolster the belief that VSV-EBOV could be the drug Ebola-fighters have been waiting for. (wuft.org)
  • As the race for an Ebola vaccine continues, experts gathered in Ghana from 8-10 April 2015 to review the clinical trial application for the Janssen Ebola Zaire Vaccine that will take place in Sierra Leone. (who.int)
  • Ebola Zaire vaccine is approved in Europe and the United States. (medscape.com)
  • Outbreaks of Ebola virus appear to begin when a human comes into contact with an infected animal or its body fluids. (go.com)
  • An Ebola vaccine will take the next critical steps in development under a $24.75 million contract through May 2020 between the U.S. Department of Health and Human Services' Office of the Assistant Secretary for Preparedness and Response (ASPR) and BioProtection Systems Corp. (BPS) of Ames, Iowa. (infectioncontroltoday.com)
  • It is "vital that we ensure global preparedness for Ebola given that the world's largest Ebola outbreaks have taken place in the last six years alone, with the latest currently underway in the Democratic Republic of the Congo (DRC)," said Paul Stoffels, chief scientific officer of Johnson & Johnson. (pharmatimes.com)
  • In countries with importations, emergency Ebola control measures stopped outbreaks, though preparedness in some countries remained weak. (who.int)
  • An Ebola project harnesses state-of-the-art technologies that illuminate mechanisms of vaccine immunogenicity and reactogenicity. (ox.ac.uk)
  • It appears to work only against one of the two most common strains of Ebola and it is not clear how long the protection it offers will last. (beckershospitalreview.com)
  • The new vaccine is designed to protect against both the Zaire and the Sudan strains of the virus. (hcplive.com)
  • The vaccine, which contains genetic material from two Ebola strains (Sudan and Zaire) was administered to ten individuals at a low dose and and to a further ten at a high dose. (facmedicine.com)
  • Ad26.ZEBOV is a monovalent vaccine and MVA-BN-Filo is a multivalent vaccine and both are designed to provide active specific acquired immunity to fight the Ebola virus. (nasdaq.com)
  • It does not contain infectious material, and people cannot catch Ebola from the vaccine , experts said. (livescience.com)
  • even though the vaccine isn't 100% effective at stopping the virus, studies have shown that the symptoms and complications tend to be less severe after a patient has been vaccinated - and there seems to be no evidence thus far that an inhalable vaccine is any less effective against the influenza virus. (webworldtoday.com)
  • A needle-free, inhalable vaccine against Ebola presents certain advantages," said lead author Michelle Meyer, UTMB postdoctoral fellow in the department of pathology. (globalbiodefense.com)
  • Public health experts and the Obama administration opposed instituting a travel ban on Ebola endemic areas, stating that it would be ineffective and would paradoxically worsen the situation. (wikipedia.org)
  • Primary exposure - This typically involves travel to or work in an Ebola-endemic area. (medscape.com)
  • Within four weeks of receiving the injections, all twenty volunteers had produced anti-Ebola antibodies. (facmedicine.com)
  • The AdVac technology is also being used to develop vaccine candidates to protect against SARS-CoV-2, as well as Zika, RSV and HIV. (nasdaq.com)
  • In September 2014, WHO identified both VSV and the ChAd3 vaccine as the most advanced candidates for use in the West African outbreak, mainly because both appeared to protect people after a single inoculation. (go.com)
  • At his laboratory at the University of Hawaii John A. Burns School of Medicine in Honolulu, researcher Axel Lehrer has several vaccine candidates that potentially could save lives around the globe. (staradvertiser.com)
  • In Congo, WHO saw 71 cases among the 93,965 at-risk people who received the vaccine. (fiercebiotech.com)
  • Ebola vaccines are vaccines either approved or in development to prevent Ebola. (wikipedia.org)
  • A clinical trial to evaluate an experimental Ebola vaccine has been launched in Mali by the Center for Vaccine Development (CVD) at the University of Maryland School of Medicine (UM SOM), the Center for Vaccine Development of Mali (CVD-Mali) and Mali's Ministry of Health. (genengnews.com)
  • Today's agreement builds on previous Ebola vaccine development efforts undertaken by BPS with support from ASPR's Biomedical Advanced Research and Development Authority (BARDA). (infectioncontroltoday.com)
  • As a division of ASPR, BARDA takes a comprehensive integrated portfolio approach to advanced research and development, innovation, acquisition, and manufacturing of vaccines, drugs, diagnostic tools, and non-pharmaceutical products for public health emergency threats. (infectioncontroltoday.com)
  • Commenting on the trial, Ripley Ballou, MD, head of Ebola vaccine research at Glaxo, said "We are accelerating development of this Ebola candidate vaccine at an unprecedented rate to try to help with help with the control of this terrible outbreak. (hcplive.com)
  • In a blog post, Berkeley's Michael Eisen writes , "Even if you believe the only thing holding up development of the Ebola vaccine was funds, it's still false to argue that with more money we'd have an Ebola vaccine. (thefiscaltimes.com)
  • Vaccine and drug development just simply doesn't work this way. (thefiscaltimes.com)
  • Currently, there are six vaccines at different stages of development - three in the United States, one in Britain, one in Mali and one in Switzerland. (ibtimes.co.uk)
  • In October 2014, Johnson & Johnson announced a commitment to accelerate and significantly expand production of an Ebola vaccine program in development at its Janssen Pharmaceutical Companies. (jnj.com)
  • Prepared by 26 experts in various realms of vaccine work and public health, the document builds on an interim report, published in January, that set out guiding principles for Ebola vaccine development. (superdoctors.com)
  • Other vaccines are also in development in Russia. (pharmexec.com)
  • Pending approval through an Investigative New Drug Application, the aerosolized form of the vaccine will be evaluated for replication, safety and immunity development in a study in adults. (globalbiodefense.com)
  • Because the countries with the worst outbreaks are primarily countries with very little in terms of healthcare supplies and training, vaccines are often difficult to administer because a trained medical technician must be administering the dose. (webworldtoday.com)
  • Johnson & Johnson is among the other companies developing Ebola vaccines. (fiercebiotech.com)
  • We are committed to finding a way to support the fight to get to and stay at zero Ebola cases worldwide," said Paul Stoffels, M.D., Chief Scientific Officer and Worldwide Chairman, Pharmaceuticals, Johnson & Johnson. (jnj.com)
  • What are the current treatments for Ebola? (go.com)
  • While much work still needs to be done, the identification of this vulnerable shared region on the surface of ebolaviruses is an important step toward creating effective treatments or vaccines. (nih.gov)
  • There currently are no vaccines or treatments approved for use against Ebola. (infectioncontroltoday.com)
  • There are currently no approved treatments or vaccines specifically for COVID-19. (theworld.org)
  • The meeting facilitated by WHO under the platform of the African Vaccine Regulatory Forum (AVAREF) was attended by 60 expert representatives of the Ethics Committee and the Pharmacy Board of Sierra Leone with support from Ghana's Food and Drug Authority (GFDA), Health Canada, the European Medicines Agency, the Medicines and Healthcare Products Regulatory Agency (MHRA) United Kingdom, and the United States Food and Drug Administration (US FDA). (who.int)
  • Human trials of the Ebola vaccine have been temporarily shut down due to adverse side effects. (thedailybeast.com)
  • The trials were designed and launched on an expedited basis given the seriousness of Ebola. (genengnews.com)
  • In the first test of an Ebola virus vaccine in the US, the University of Maryland announced it will soon start human trials. (hcplive.com)
  • This is the first time it'll be used in a new outbreak," said John-Arne Røttingen, chief executive of the Research Council of Norway, who worked on the Ebola vaccine trials. (vox.com)
  • Dr Matthew Snape of the Oxford Vaccine Group, who leading the Janssen vaccine study team, said: 'The fact that there are at least three Ebola vaccines entering these early safety trials is good news. (pharmexec.com)
  • A nasal vaccine against Ebola has been shown to protect monkeys against the virus for over a year after administering it. (ibtimes.co.uk)
  • Created by the Public Health Agency of Canada in 2003, the vaccine was shown to be 100 percent effective in monkeys. (vox.com)
  • Studies have shown these vaccines offer full protection in mice and monkeys, said Lehrer, an associate professor at JABSOM's Department of Tropical Medicine, Medical Microbiology and Pharmacology. (staradvertiser.com)

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