Retinitis Pigmentosa: Hereditary, progressive degeneration of the neuroepithelium of the retina characterized by night blindness and progressive contraction of the visual field.Cytomegalovirus Retinitis: Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in AIDS patients and can cause blindness.Retinitis: Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).Electroretinography: Recording of electric potentials in the retina after stimulation by light.Eye ProteinsRhodopsin: A purplish-red, light-sensitive pigment found in RETINAL ROD CELLS of most vertebrates. It is a complex consisting of a molecule of ROD OPSIN and a molecule of 11-cis retinal (RETINALDEHYDE). Rhodopsin exhibits peak absorption wavelength at about 500 nm.Eye Infections, Viral: Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)Photoreceptor Cells, Vertebrate: Specialized PHOTOTRANSDUCTION neurons in the vertebrates, such as the RETINAL ROD CELLS and the RETINAL CONE CELLS. Non-visual photoreceptor neurons have been reported in the deep brain, the PINEAL GLAND and organs of the circadian system.Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.Genes, Dominant: Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Ganciclovir: An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.Fundus Oculi: The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)Visual Acuity: Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.Genes, Recessive: Genes that influence the PHENOTYPE only in the homozygous state.AIDS-Related Opportunistic Infections: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.Peripherins: Type III intermediate filament proteins expressed mainly in neurons of the peripheral and CENTRAL NERVOUS SYSTEMS. Peripherins are implicated in neurite elongation during development and axonal regeneration after injury.Genetic Diseases, X-Linked: Genetic diseases that are linked to gene mutations on the X CHROMOSOME in humans (X CHROMOSOME, HUMAN) or the X CHROMOSOME in other species. Included here are animal models of human X-linked diseases.Dark Adaptation: Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation.Photoreceptor Cells: Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade.Cyclic Nucleotide Phosphodiesterases, Type 6: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.Visual Fields: The total area or space visible in a person's peripheral vision with the eye looking straightforward.Retinal Rod Photoreceptor Cells: Photosensitive afferent neurons located in the peripheral retina, with their density increases radially away from the FOVEA CENTRALIS. Being much more sensitive to light than the RETINAL CONE CELLS, the rod cells are responsible for twilight vision (at scotopic intensities) as well as peripheral vision, but provide no color discrimination.Retinal Necrosis Syndrome, Acute: Mild to fulminant necrotizing vaso-occlusive retinitis associated with a high incidence of retinal detachment and poor vision outcome.Night Blindness: Failure or imperfection of vision at night or in dim light, with good vision only on bright days. (Dorland, 27th ed)Usher Syndromes: Autosomal recessive hereditary disorders characterized by congenital SENSORINEURAL HEARING LOSS and RETINITIS PIGMENTOSA. Genetically and symptomatically heterogeneous, clinical classes include type I, type II, and type III. Their severity, age of onset of retinitis pigmentosa and the degree of vestibular dysfunction are variable.Retinal Cone Photoreceptor Cells: Photosensitive afferent neurons located primarily within the FOVEA CENTRALIS of the MACULA LUTEA. There are three major types of cone cells (red, blue, and green) whose photopigments have different spectral sensitivity curves. Retinal cone cells operate in daylight vision (at photopic intensities) providing color recognition and central visual acuity.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Genetic Linkage: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Vitreous Body: The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.Blindness: The inability to see or the loss or absence of perception of visual stimuli. This condition may be the result of EYE DISEASES; OPTIC NERVE DISEASES; OPTIC CHIASM diseases; or BRAIN DISEASES affecting the VISUAL PATHWAYS or OCCIPITAL LOBE.Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Rod Opsins: Photosensitive proteins expressed in the ROD PHOTORECEPTOR CELLS. They are the protein components of rod photoreceptor pigments such as RHODOPSIN.Visual Field Tests: Method of measuring and mapping the scope of vision, from central to peripheral of each eye.Consanguinity: The magnitude of INBREEDING in humans.Fluorescein Angiography: Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Retinal DiseasesX Chromosome: The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in human and other male-heterogametic species.Vision Disorders: Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from EYE DISEASES; OPTIC NERVE DISEASES; VISUAL PATHWAY diseases; OCCIPITAL LOBE diseases; OCULAR MOTILITY DISORDERS; and other conditions (From Newell, Ophthalmology: Principles and Concepts, 7th ed, p132).Exons: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.Mutation, Missense: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)Eye Diseases, Hereditary: Transmission of gene defects or chromosomal aberrations/abnormalities which are expressed in extreme variation in the structure or function of the eye. These may be evident at birth, but may be manifested later with progression of the disorder.Tomography, Optical Coherence: An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.Herpes Zoster Ophthalmicus: Virus infection of the Gasserian ganglion and its nerve branches characterized by pain and vesicular eruptions with much swelling. Ocular involvement is usually heralded by a vesicle on the tip of the nose. This area is innervated by the nasociliary nerve.Interleukin-10 Receptor alpha Subunit: A subunit of the interleukin-10 receptor. It plays a role in receptor signaling by associating with JANUS KINASE 1.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Homozygote: An individual in which both alleles at a given locus are identical.IMP Dehydrogenase: An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 220.127.116.11.Uveitis: Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)Fovea Centralis: An area approximately 1.5 millimeters in diameter within the macula lutea where the retina thins out greatly because of the oblique shifting of all layers except the pigment epithelium layer. It includes the sloping walls of the fovea (clivus) and contains a few rods in its periphery. In its center (foveola) are the cones most adapted to yield high visual acuity, each cone being connected to only one ganglion cell. (Cline et al., Dictionary of Visual Science, 4th ed)Leber Congenital Amaurosis: A rare degenerative inherited eye disease that appears at birth or in the first few months of life that results in a loss of vision. Not to be confused with LEBER HEREDITARY OPTIC NEUROPATHY, the disease is thought to be caused by abnormal development of PHOTORECEPTOR CELLS in the RETINA, or by the extremely premature degeneration of retinal cells.Laurence-Moon Syndrome: An autosomal recessive condition characterized by hypogonadism; spinocerebellar degeneration; MENTAL RETARDATION; RETINITIS PIGMENTOSA; and OBESITY. This syndrome was previously referred to as Laurence-Moon-Biedl syndrome until BARDET-BIEDL SYNDROME was identified as a distinct entity. (From N Engl J Med. 1989 Oct 12;321(15):1002-9)Chorioretinitis: Inflammation of the choroid in which the sensory retina becomes edematous and opaque. The inflammatory cells and exudate may burst through the sensory retina to cloud the vitreous body.Carbonic Anhydrase IV: A membrane-bound carbonic anhydrase found in lung capillaries and kidney.Eye Infections: Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.Ribonucleoprotein, U4-U6 Small Nuclear: A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U4-U6 snRNP along with the U5 snRNP preassemble into a single 25S particle that binds to the U1 and U2 snRNPs and the substrate to form mature SPLICEOSOMES. There is also evidence for the existence of individual U4 or U6 snRNPs in addition to their organization as a U4-U6 snRNP.Retinal Dysplasia: Congenital, often bilateral, retinal abnormality characterized by the arrangement of outer nuclear retinal cells in a palisading or radiating pattern surrounding a central ocular space. This disorder is sometimes hereditary.Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.Polymorphism, Single-Stranded Conformational: Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.Retinal Photoreceptor Cell Outer Segment: The light sensitive outer portion of a retinal rod or a cone photoreceptor cell. The outer segment contains a stack of disk membranes laden with photoreceptive pigments (RETINAL PIGMENTS). The outer segment is connected to the inner segment by a PHOTORECEPTOR CONNECTING CILIUM.Tetraspanins: A large superfamily of cell surface membrane proteins characterized by their four transmembrane domains. They play a role in a variety of processes such as cellular adhesion and motility. They may be involved in the organization of cell surface MEMBRANE MICRODOMAINS that regulate the activation of LEUKOCYTES.Lod Score: The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. Lod is an acronym for "logarithmic odds."Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Intermediate Filament Proteins: Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.Eye Diseases: Diseases affecting the eye.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Photoreceptor Connecting Cilium: The bridge between the inner and the outer segments of a retinal rod or a cone photoreceptor cell. Through it, proteins synthesized in the inner segment are transported to the outer segment.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Frameshift Mutation: A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.Sensory Thresholds: The minimum amount of stimulus energy necessary to elicit a sensory response.Organophosphonates: Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.Opsins: Photosensitive proteins in the membranes of PHOTORECEPTOR CELLS such as the rods and the cones. Opsins have varied light absorption properties and are members of the G-PROTEIN-COUPLED RECEPTORS family. Their ligands are VITAMIN A-based chromophores.Organophosphorus Compounds: Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.Cytosine: A pyrimidine base that is a fundamental unit of nucleic acids.Macula Lutea: An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototropic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)Toxoplasmosis, Ocular: Infection caused by the protozoan parasite TOXOPLASMA in which there is extensive connective tissue proliferation, the retina surrounding the lesions remains normal, and the ocular media remain clear. Chorioretinitis may be associated with all forms of toxoplasmosis, but is usually a late sequel of congenital toxoplasmosis. The severe ocular lesions in infants may lead to blindness.Ophthalmoscopy: Examination of the interior of the eye with an ophthalmoscope.cis-trans-Isomerases: Enzymes that catalyze the rearrangement of geometry about double bonds. EC 5.2.Genes, X-Linked: Genes that are located on the X CHROMOSOME.Muromegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, causing infection involving several organs in mice and rats. Murid herpesvirus is the type species.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.CD4 Lymphocyte Count: The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.Optic Atrophy, Hereditary, Leber: A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001))Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Phosphenes: A subjective visual sensation with the eyes closed and in the absence of light. Phosphenes can be spontaneous, or induced by chemical, electrical, or mechanical (pressure) stimuli which cause the visual field to light up without optical inputs.Syndrome: A characteristic symptom complex.Vision, Ocular: The process in which light signals are transformed by the PHOTORECEPTOR CELLS into electrical signals which can then be transmitted to the brain.Heterozygote: An individual having different alleles at one or more loci regarding a specific character.Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.Macular Edema: Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90)Drug Implants: Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.Intravitreal Injections: The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.Pigment Epithelium of Eye: The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.Vision Tests: A series of tests used to assess various functions of the eyes.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Bardet-Biedl Syndrome: An autosomal recessive disorder characterized by RETINITIS PIGMENTOSA; POLYDACTYLY; OBESITY; MENTAL RETARDATION; hypogenitalism; renal dysplasia; and short stature. This syndrome has been distinguished as a separate entity from LAURENCE-MOON SYNDROME. (From J Med Genet 1997 Feb;34(2):92-8)Retinal Dystrophies: A group of disorders involving predominantly the posterior portion of the ocular fundus, due to degeneration in the sensory layer of the RETINA; RETINAL PIGMENT EPITHELIUM; BRUCH MEMBRANE; CHOROID; or a combination of these tissues.Codon, Nonsense: An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.Point Mutation: A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.Retinal Pigment Epithelium: The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Injections: Introduction of substances into the body using a needle and syringe.Retinal Detachment: Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).Cilia: Populations of thin, motile processes found covering the surface of ciliates (CILIOPHORA) or the free surface of the cells making up ciliated EPITHELIUM. Each cilium arises from a basic granule in the superficial layer of CYTOPLASM. The movement of cilia propels ciliates through the liquid in which they live. The movement of cilia on a ciliated epithelium serves to propel a surface layer of mucus or fluid. (King & Stansfield, A Dictionary of Genetics, 4th ed)Vision, Low: Vision considered to be inferior to normal vision as represented by accepted standards of acuity, field of vision, or motility. Low vision generally refers to visual disorders that are caused by diseases that cannot be corrected by refraction (e.g., MACULAR DEGENERATION; RETINITIS PIGMENTOSA; DIABETIC RETINOPATHY, etc.).Antiretroviral Therapy, Highly Active: Drug regimens, for patients with HIV INFECTIONS, that aggressively suppress HIV replication. The regimens usually involve administration of three or more different drugs including a protease inhibitor.Anterior Chamber: The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)Murine Acquired Immunodeficiency Syndrome: Acquired defect of cellular immunity that occurs in mice infected with mouse leukemia viruses (MuLV). The syndrome shows striking similarities with human AIDS and is characterized by lymphadenopathy, profound immunosuppression, enhanced susceptibility to opportunistic infections, and B-cell lymphomas.Rod Cell Outer Segment: The portion of a retinal rod cell situated between the ROD INNER SEGMENT and the RETINAL PIGMENT EPITHELIUM. It contains a stack of photosensitive disk membranes laden with RHODOPSIN.Rats, Transgenic: Laboratory rats that have been produced from a genetically manipulated rat EGG or rat EMBRYO, MAMMALIAN. They contain genes from another species.Visual Prosthesis: Artificial device such as an externally-worn camera attached to a stimulator on the RETINA, OPTIC NERVE, or VISUAL CORTEX, intended to restore or amplify vision.Fluorescent Antibody Technique, Indirect: A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Ophthalmoscopes: Devices for examining the interior of the eye, permitting the clear visualization of the structures of the eye at any depth. (UMDNS, 1999)Electrooculography: Recording of the average amplitude of the resting potential arising between the cornea and the retina in light and dark adaptation as the eyes turn a standard distance to the right and the left. The increase in potential with light adaptation is used to evaluate the condition of the retinal pigment epithelium.Aqueous Humor: The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Arrestin: A 48-Kd protein of the outer segment of the retinal rods and a component of the phototransduction cascade. Arrestin quenches G-protein activation by binding to phosphorylated photolyzed rhodopsin. Arrestin causes experimental autoimmune uveitis when injected into laboratory animals.Optic Atrophies, Hereditary: Hereditary conditions that feature progressive visual loss in association with optic atrophy. Relatively common forms include autosomal dominant optic atrophy (OPTIC ATROPHY, AUTOSOMAL DOMINANT) and Leber hereditary optic atrophy (OPTIC ATROPHY, HEREDITARY, LEBER).Eye: The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.RNA Splicing: The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.Retinal Bipolar Cells: INTERNEURONS of the vertebrate RETINA containing two processes. They receive inputs from the RETINAL PHOTORECEPTOR CELLS and send outputs to the RETINAL GANGLION CELLS. The bipolar cells also make lateral connections in the retina with the RETINAL HORIZONTAL CELLS and with the AMACRINE CELLS.
PMID 19818505 "ScienceDaily: Drug Slows Blindness In AIDS Patients". Retrieved 2010-04-28. "Mount Sinai Hospital - Doctor ... He has chaired five randomized, controlled, clinical trials on the treatment of CMV retinitis and now chairs a multicenter ... Comparison of antimetabolite drugs as corticosteroid-sparing therapy for noninfectious ocular inflammation. Ophthalmology 2008; ... PMID 19578087 Jabs DA, Martin BK, Forman MS, for the Cytomegalovirus Retinitis and Viral Resistance Research Group. Mortality ...
"Cidofovir Monograph for Professionals - Drugs.com". Drugs.com. American Society of Health-System Pharmacists. Retrieved 5 ... Its only indication that has received regulatory approval worldwide is cytomegalovirus retinitis. Cidofovir has also shown ... Despite this, the drug failed to demonstrate any efficacy in controlled studies. Cidofovir might have anti-smallpox efficacy ... Probenecid (a uricosuric drug) and intravenous saline should always be administered with each cidofovir infusion to prevent ...
It was granted orphan drug status for Leber congenital amaurosis and retinitis pigmentosa. A biologics license application was ... The US FDA approved the drug on December 19, 2017. With the approval, Spark Therapeutics received a pediatric disease priority ... On 12 October 2017, a key advisory panel to the Food and Drug Administration (FDA), composed of 16 experts, unanimously ...
... (brand name Vitravene) is an antisense antiviral drug that was used in the treatment of cytomegalovirus retinitis ( ... The drug was withdrawn because while there was a high unmet need for drugs to treat CMV when the drug was initially discovered ... MedlinePlus DrugInfo uspdi-203675 DDB 31313 "Vitravene (Fomivirsen) Drug Information: Uses, Side Effects, Drug Interactions and ... It was licensed by the FDA for CMV in Aug 1998, and was the first antisense drug that was approved. Novartis withdrew the ...
Alan started Stone on drug therapy. Mac Scorpio, Robin's uncle was furious when he found out, but he cared for Stone and even ... Stone's eyesight started to fail due to CMV retinitis worsened by his illness. Right before he died he was able to focus on ... Sonny was seeing Karen and got her hooked on drugs. Jagger found his little brother at his girlfriend Krystal's grave site and ...
Despite the promises of asRNAs as drug targets or drug candidates, there are some challenges remained to be address. First of ... Fomivirsen, a 21 base-pair oligonucleotide, was developed to treat cytomegalovirus retinitis in patients with AIDS. It works by ... Due to the nature of drug development, it is always easier to have drugs functioning as downregulators or inhibitors. However, ... Since then, much effect has been devoted to developing asRNAs as drug candidates. In 1998, the first asRNA drug, fomivirsen, ...
... pharmacokinetic properties and therapeutic use in immunocompromised patients with cytomegalovirus retinitis". Drugs. 41 (1): ... Valganciclovir (Valcyte) is an antiviral drug that is also effective and is given orally: it is a pro-drug that gets converted ... HCMV antiviral drug resistance can be detected by phenotypic or by genotypic drug resistance testing. Phenotypic resistance ... The second drug, Cidofovir (CDV), is a nucleotide analogue, which is already phosphorylated and thus active. Finally, Foscarnet ...
A number of drugs can cause changes in the retina that can lead to macular edema. The effect of each drug is variable and some ... A few congenital diseases are known to be associated with macular edema for example retinitis pigmentosa and retinoschisis. ... Prophylactic use of Nonsteroidal anti-inflammatory drugs has been reported to reduce the risk of macular edema to some extent. ... The cause for CME can be remembered with the mnemonic "DEPRIVEN" (diabetes, epinepherine, pars planitis, retinitis pigmentosa, ...
U.S. Food and Drug Administration. 14 February 2013. Retrieved 14 March 2015. J. Stone; W. Barlow; M. Humayun; E. deJuan Jr.; A ... Optimal candidates for retinal implants have retinal diseases, such as retinitis pigmentosa or age-related macular degeneration ... M. Humayun (1999). "Morphometric analysis of the extra- macular retina from post mortem eyes with retinitis pigmentosa". ... 1997). "Preservation of the inner retina in retinitis pigmentosa: A morphometric analysis". Archives of Ophthalmology. 115: 511 ...
Retinitis pigmentosa, a disease of the eye. Blood loss (hypovolemia) Alcohol consumption. In addition, the vision becomes ... Hallucinogenic drugs, in particular the dissociatives. Extreme fear or distress, most often in the context of a panic attack. ... "Retinitis pigmentosa". Genetics Home Reference. 2016-02-15. Retrieved 2016-02-21. Effects of Alcohol on Vision Web Archive: ...
Mutations in the CBS region of IMPDH1 are associated with the RP10 form of autosomal dominant retinitis pigmentosa and dominant ... Therefore, IMPDH has been addressed as a drug target for immunosuppressive and cancer chemotherapy. Mycophenolate is an ... Mortimer, Sarah E.; Hedstrom, Lizbeth (2005). "Autosomal dominant retinitis pigmentosa mutations in inosine 5'-monophosphate ... "Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital ...
Signs and symptoms of HIV/AIDS
Its main consequence is anemia, which is difficult to distinguish from the effects of antiretroviral drugs used to treat AIDS ... and CMV retinitis can cause blindness. Penicilliosis due to Penicillium marneffei is now the third most common opportunistic ... This syndrome is less frequently seen with the advent of multi-drug therapy. People with HIV infections have substantially ... diarrhea may be a side effect of several drugs used to treat HIV, or it may simply accompany HIV infection, particularly during ...
Drug tolerance does not develop in most cases, but has individually occurred. Flupirtine is a selective neuronal potassium ... "Adeona Pharmaceuticals and National Neurovision Research Institute (NNRI) Collaborate to Test Flupirtine for Retinitis ... Flupirtine Drugs.com. Accessed 30 August 2016 McMahon FG, Arndt WF, Newton JJ, Montgomery PA, Perhach JL (1987). "Clinical ... Flupirtine showed promise for fibromyalgia due to its different action than the three approved by U.S. FDA drugs: pregabalin, ...
Foundation Fighting Blindness
Valproic acid, a drug that is FDA-approved to treat epilepsy, has shown promise for preserving vision in people with certain ... forms of retinitis pigmentosa. The Foundation has launched a human trial to test this drug and, if effective, move it quickly ... Blind from retinitis pigmentosa, Gund is Chairman of the Foundation Fighting Blindness and Chief Executive Officer and Chairman ... Retinitis Pigmentosa Macular Degeneration Usher Syndrome Stargardt's disease Leber's congenital amaurosis  The National ...
... (INN; brand name Xadago) is a drug used as an add-on treatment for Parkinson's disease during "off" episodes; it has ... Safinamide is contraindicated in people with severe liver impairment, with albinism, retinitis pigmentosa, severe diabetic ... Chazot, PL (2007). "Drug evaluation: Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome ... The US Food and Drug Administration (FDA) refused to file Newron's application in 2014 on formal grounds. Newron re-applied in ...
2008). "Retinitis pigmentosa: mutation analysis of RHO, PRPF31, RP1, and IMPDH1 genes in patients from India". Mol. Vis. 14: ... 2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics. 83 (4): 566-71. doi: ... Defects in the IMPDH1 gene are a cause of retinitis pigmentosa type 10 (RP10). IMP dehydrogenase GRCh38: Ensembl release 89: ... GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview This article incorporates text from the United States National ...
Other nephrotoxic drugs should be avoided. Nephrotoxicity is usually reversible and can be reduced by dosage adjustment and ... It is particularly used to treat CMV retinitis. Foscarnet can be used to treat highly treatment-experienced patients with HIV ... 2006). "Foscarnet salvage therapy for patients with late-stage HIV disease and multiple drug resistance". Antivir. Ther. (Lond ... It usually resolves rapidly following discontinuation of the drug. CNS - Paraesthesias,irritability and hallucinations Foscavir ...
Progressive outer retinal necrosis
Systemic antiviral drugs may improve the long-term visual outcome in those with the disease. Cytomegalovirus retinitis List of ... "Management of varicella zoster virus retinitis in AIDS." Br J Ophthalmol. 1997 Mar;81(3):189-94. PMID 9135381 Copeland R, ... Progressive outer retinal necrosis, also known as Varicella zoster virus retinitis (VZVR), is an aggressive, necrotizing ...
ATP-binding cassette transporter
Retinitis pigmentosum, cone rod dystrophy, and others. The human ABCB (MDR/TAP) family is responsible for multiple drug ... Drug Resistance ATPase-1 (Drug RA1) (Putative) Drug Resistance ATPase-2 (Drug RA2) Macrolide Exporter (MacB) Peptide-4 Exporter ... The latter scenario can lead to drug-drug interactions, sometimes resulting in altered effects of the drugs. There are a number ... This assay type is particularly suitable for the detection of possible drug-drug interactions and drug-endogenous substrate ...
Benitec Biopharma Ltd
Index of HIV/AIDS-related articles
... antiretroviral drugs - antisense drugs - antitoxins - Antiviral drug - aphasia - aphthous ulcer - apoptosis - approved drugs - ... Cytomegalovirus retinitis - cytopenia - cytotoxic - cytotoxic T lymphocyte (CTL) DAIDS - data safety and monitoring board (DSMB ... drug resistance - drug-drug interaction - DSMB - Duffy antigen system - dysplasia - dyspnea efficacy - empirical - encephalitis ... multi-drug rescue therapy - multiple drug-resistant tuberculosis (MDR-TB) - mutation - myalgia - mycobacterium - mycobacterium ...
Food and Drug Administration (FDA): fomivirsen as a treatment for cytomegalovirus retinitis, mipomersen for homozygous familial ... Therefore, antisense drug candidate molecules are generally modified during the drug discovery phase of their development. ... FDA approves new orphan drug Kynamro to treat inherited cholesterol disorder U.S. Food and Drug Administration, Retrieved 31 ... These drugs, AVI-6002 and AVI-6003 are novel analogs based on AVI's PMO antisense chemistry in which anti-viral potency is ...
Gholam A. Peyman
Intravitreal antineoplastic (cancer) - Toxicity of antineoplastic drugs in vitrectomy infusion fluids (1983 and 1984) drugs ... 1984) Parenterally-administered acyclovir for viral retinitis associated with AIDS (1984) Intravitreal toxicity of ... he initiated the evaluation of direct intra-ocular drug delivery. This method has now become an alternative route of drug ... Toxicity of intravitreal antiviral drugs (1984) Vitrectomy and intravitreal antiviral drug therapy in acute retinal necrosis ...
In addition to deep mycotic disease, C. atrobrunneum is known to eye diseases including retinitis and keratitis, manifesting ... Infections due to this species have typically occurred following invasive procedures such as intravenous drug administration ... Tabbara, Khalid F.; Wedin, Keith; Al Haddab, Saad (2010). "CHAETOMIUM RETINITIS". Retinal Cases & Brief Reports. 4 (1): 8-10. ... Co-administration of the antifungal drugs fluconazole (delivered topically) and itraconazole (delivered orally) have been ...
DNA-directed RNA interference
McCarroll, J. A.; Gan, P. P.; Liu, M.; Kavallaris, M. (2010). "III-Tubulin is a Multifunctional Protein Involved in Drug ... advanced cancer and retinitis pigmentosa. As seen in Figure 1, a ddRNAi construct encoding an shRNA is packaged into a delivery ... or diseases associated with altered expression of endogenous genes such as drug-resistant lung cancer, neuropathic pain, ... "Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa". ...
AIDS Clinical Trials Group
Integral involvement in new antiretroviral drug development: Zidovudine, Zalcitabine, Didanosine, Stavudine, nevirapine, ... Pneumocystis carinii pneumonia Cytomegalovirus retinitis Cryptococcal meningitis Toxoplasmic encephalitis Hepatitis B and ... drugs or treatment strategies) that prevent or delay the complications of HIV-related disorders HIV-1 pathogenesis through ... the results of which suggested men and women respond to antiretroviral drugs differently. In 2006, the network was funded as ...
Retinitis pigmentosa and related hereditary degenerations Retinitis punctata albescens Leber's congenital amaurosis ... The ERG is also used to monitor retinal toxicity in many drug trials. Autoimmune retinopathies such as Cancer Associated ... 2005). "An overview of drug development with special emphasis on the role of visual electrophysiological testing". Doc ... X-linked juvenile retinoschisis Achromatopsia Cone dystrophy Disorders mimicking retinitis pigmentosa Usher Syndrome Other ...
The company's first marketed drug was fomivirsen (Vitravene) which was used in the treatment of cytomegalovirus retinitis (CMV ... While initially, the rising incidence of CMV in people with AIDS created a need for drugs that treated this virus, the drug was ... genital warts drug candidate. The company and others founded to bring antisense drugs to market faced early failures; Isis' ... The drug was initially developed by Ionis, which partnered with Biogen on development starting in 2012, and in 2015 Biogen ...
Healthcare in Cuba
Items which are paid by patients who can afford it are: drugs prescribed on an outpatient basis, hearing, dental, and ... retinitis pigmentosa and orthopaedics. Most patients are from Latin America, Europe and Canada, and a growing number of ... "Patients pay for drugs, hearing, dental, and orthopedic prostheses, wheelchairs, crutches, and similar items but prices are low ... In that film, Moore took a number of Americans to a hospital in Havana where they bought affordable drugs, and were given ...
Drugs associated with reactivation. Since immunodeficiency causes this virus to progress to PML, immunosuppressants are ... The boxed warning had been included for the drugs Tecfidera and Gilenya, both of which have had incidences of PML resulting in ... The drug was pulled off the U.S. market because of the association with PML on April 10, 2009. ... The boxed warning was added on February 19, 2009, for the drug efalizumab (Raptiva) includes a statement that JC virus, ...
Index of HIV/AIDS-related articles
... antiretroviral drugs - antisense drugs - antitoxins - Antiviral drug - aphasia - aphthous ulcer - apoptosis - approved drugs - ... retinitis - retrovirus - REV - reverse transcriptase - ribonucleic acid (RNA) - ribosome - RNA - route of administration - RT- ... drug resistance - drug-drug interaction - DSMB - Duffy antigen system - dysplasia - dyspnea ... multi-drug rescue therapy - multiple drug-resistant tuberculosis (MDR-TB) - mutation - myalgia - mycobacterium - mycobacterium ...
Succinic semialdehyde dehydrogenase deficiency
"Myambutol (Ethambutol) Drug Information: Description, User Reviews, Drug Side Effects, Interactions-Prescribing Information at ... retinitis pigmentosa (initially affects rods but can later progress to cones and therefore color blindness). ... Acquired: Diseases, drugs (e.g., Plaquenil), and chemicals[clarification needed] may cause color blindness. ... Red-green color blindness can be caused by ethambutol, a drug used in the treatment of tuberculosis. ...
They may also be the result of acquired mitochondrial dysfunction due to adverse effects of drugs, infections, or other ... Neuropathy, ataxia, retinitis pigmentosa, and ptosis (NARP) *progressive symptoms as described in the acronym ... A pathophysiologically informed paradigm for new drug development". Australian & New Zealand Journal of Psychiatry. 47 (1): 26- ... A pathophysiologically informed paradigm for new drug development". Australian & New Zealand Journal of Psychiatry. 47 (1): 26- ...
Drugs that can lead to vasoconstriction should be avoided. If blood pressure is too low, sleeping pills should be taken ... People suffering from retinitis pigmentosa seem to have Flammer syndrome quite frequently, possible associations with the ... 2015). "Endothelin-1 Plasma Levels in Patients with both Retinitis Pigmentosa and Flammer Syndrome". Klin Monatsbl Augenheilkd ... sensitivity to certain drugs migraine tinnitus reversible patchy white or red discoloration of the skin. People with Flammer ...
Kaposi's sarcoma-associated herpesvirus
Antiviral drugs, such as ganciclovir, that target the replication of herpesviruses such as KSHV have been used to successfully ... "Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study Group ... Chemotherapy with drugs such as liposomal anthracyclines or paclitaxel may be used, particularly for invasive disease. ... prevent development of Kaposi's sarcoma, although once the tumor develops these drugs are of little or no use. For patients ...
WHO Model List of Essential Medicines
World Health Organization (1977). The selection of essential drugs : report of a WHO expert committee [meeting held in Geneva ... For the treatment of cytomegalovirus retinitis (CMVr). *^ For severe illness due to confirmed or suspected influenza virus ... Rose, K; Anker, JNVd (2010). Guide to Paediatric Drug Development and Clinical Research. Karger Medical and Scientific ...
Hepatitis C virus
"Food and Drug Administration. Nov 22, 2013.. *^ "Medivir: Simeprevir has been approved in Japan for the treatment of genotype 1 ... It has been reported to be the first drug that has demonstrated safety and efficacy to treat certain types of HCV infection ... There is also current experimental research on non drug related therapies. Oxymatrine, for example, is a root extract found in ... Nat Rev Drug Discov. 6 (12): 991-1000. doi:10.1038/nrd2411. PMID 18049473. S2CID 52874660.. ...
人類乳突病毒 - 维基百科，自由的百科
Human interaction with cats
... but also for drug delivery and drug discovery.  Leukocyte adhesion deficiency. Main article: Leukocyte adhesion ... Having this knowledge allows for better studies of the effect of drugs on leukocyte extravasation. ... thereby providing a methodology to quantify the effect of the drug in impeding leukocyte extravasation. Some of the recent ...
"Myambutol (Ethambutol) Drug Information: Description, User Reviews, Drug Side Effects, Interactions-Prescribing Information at ... retinitis pigmentosa (initially affects rods but can later progress to cones and therefore color blindness). ... Acquired: Diseases, drugs (e.g., hydroxychloroquine), and chemicals such as styrene or organic solvents may cause ... Red-green color blindness can be caused by ethambutol, a drug used in the treatment of tuberculosis. ...
"U.S. Food and Drug Administration. 19 December 2017. Retrieved 18 June 2020.. ... "Retinitis Pigmentosa".. *^ Zhao GY, Hu DN, Xia HX, Xia ZC (1995). "Chinese family with retinitis pigmentosa". Opthalamic ... Retinitis pigmentosa, late-onset dominant 300455 RPGR Retinitis pigmentosa, X-linked, and sinorespiratory infections, with or ... "Retinitis pigmentosa".. *^ Bujakowska, K.; Maubaret, C.; Chakarova, C. F.; Tanimoto, N.; Beck, S. C.; Fahl, E.; Humphries, M. M ...
Ukimwi, kamusi elezo huru
... drug resistance, virologic failure: evolving concepts". Infectious disorders drug targets 11 (2): 167-74. PMID 21406048 . ... Retinitis - virusi zinashambulia nyuma ya jicho.. *Pneumocystis carinii (kifupi PCP) - aina ya pneumonia, magonjwa ya ... Reid, SR (2009-08-28). "Injection drug use, unsafe medical injections, and HIV in Africa: a systematic review". Harm reduction ... "Adherence to antiretroviral therapy for human immunodeficiency virus/acquired immune deficiency syndrome among drug users: a ...
... the pupil in the normal eye regains its function when the drugs are metabolized or carried away. Some cycloplegic drugs can ... Retinitis pigmentosa. *Retinal haemorrhage. *Central serous retinopathy. *Macular edema. *Epiretinal membrane (Macular pucker) ... Cycloplegic drugs are generally muscarinic receptor blockers. These include atropine, cyclopentolate, homatropine, scopolamine ... When cycloplegic drugs are used as a mydriatic to dilate the pupil, ...
لایه عروقی - ویکیپدیا، دانشنامهٔ آزاد
AIDS bahasa Indonesia, ensiklopedia bebas
Intravenous drug use, sexual intercourse, dialysis, living with an infected person. ... Hughes RA (March 2000). "Drug injectors and the cleaning of needles and syringes". European Addiction Research. 6 (1): 20-30. ... In low prevalence areas such as the continental United States and Western Europe, injection drug abuse and unprotected sex are ... intravenous drug use and sexual intercourse are the most frequent routes of infection. Other risk factors include working in ...
There is no drug that has established safety and effectiveness for hepatitis E, and there have been no large randomized ... In the United States no serologic tests for diagnosis of HEV infection have ever been authorized by the Food and Drug ... after more than a year of scrutiny and inspection by China's State Food and Drug Administration (SFDA), a hepatitis E vaccine ... clinical trials of antiviral drugs. Reviews of existing small studies suggest that ribavirin can be considered effective in ...
Ripps, Harris (March 2002). "Cell death in retinitis pigmentosa: gap junctions and the 'bystander' effect". Exp. Eye Res. 74 (3 ... Gap junctions were also found to be responsible for the transmission of signals required for drugs to have an effect and ... conversely some drugs were shown to block gap junction channels.. Gap junctions and the "bystander effect"Edit. Cell death ...
List of parasites of humans
CMV Retinitis Drug Recalled | Medpage Today
... retinitis in AIDS patients, has been recalled because of particulate matter in some vials, the FDA said. ... The drugs manufacturer, Gilead Sciences, has undertaken the recall voluntarily and said it had not received any complaints or ... Neither Gilead nor the FDA indicated whether the particulate matter is crystallized drug or represents some type of ... Vistide is indicated for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. ...
Amarantus Granted European Union Orphan Drug Designation for MANF for the Treatment of Retinitis Pigmentosa
... ... About Retinitis Pigmentosa. Retinitis pigmentosa (RP) refers to a group of inherited diseases causing retinal degeneration ... has granted orphan drug status for MANF (mesencephalic-astrocyte-derived neurotrophic factor) for the treatment of retinitis ... Orphan drug designation by the European Commission provides regulatory and financial incentives for companies to develop and ...
Amarantus Receives Orphan Drug Designation for MANF From U.S. Food and Drug Administration for Treatment of Retinitis Pigmentosa
Food and Drug Administration has granted the companys... ... About Retinitis Pigmentosa. Retinitis pigmentosa (RP) refers to ... Amarantus Receives Orphan Drug Designation for MANF From U.S. Food and Drug Administration for Treatment of Retinitis ... The FDA Orphan Drug Designation program provides a special status to drugs and biologics intended to treat, diagnose or prevent ... orphan drug designation for the treatment of Retinitis Pigmentosa (RP). RP refers to a group of inherited diseases causing ...
Valganciclovir in Patients With CMV Retinitis and AIDS Who Cannot Take Drugs by Injection - Full Text View - ClinicalTrials.gov
Valganciclovir in Patients With CMV Retinitis and AIDS Who Cannot Take Drugs by Injection. The safety and scientific validity ... An experimental drug, valganciclovir, is similar to 1 of these approved drugs, ganciclovir, but is more convenient and easier ... Cytomegalovirus Retinitis. Retinitis. Virus Diseases. Retinal Diseases. Eye Diseases. Cytomegalovirus Infections. Herpesviridae ... retinitis (eye infection) and cannot take drugs by injection. This study also will look at the safety of using valganciclovir ...
AGTC Files Investigational New Drug Application for the Treatment of X-linked Retinitis Pigmentosa Caused by Mutations in the...
... today announced that it has filed an Investigational New Drug application (IND) with the U.S. Food and ... AGTC Files Investigational New Drug Application for the Treatment of X-linked Retinitis Pigmentosa Caused by Mutations in the ... today announced that it has filed an Investigational New Drug application (IND) with the U.S. Food and Drug Administration to ... risks and uncertainties associated with drug development and commercialization; factors that could cause actual results to ...
Fovea Pharmaceuticals Receives Orphan Drug Designation from EC for RdCVF for the Treatment of Retinitis ... ( PARIS Jan. 7 ...
Drug,Designation,from,EC,for,RdCVF,for,the,Treatment,of,Retinitis,Pigmentosa,medicine,advanced medical technology,medical ... We are pleased to have received this orphan drug designation for RdCV...In a study on animal model of the disease performed at ... 7 /- Fovea Pharmaceuticals SA which las...Orphan drug designation would entitle Fovea to exclusive marketingrig... ... "We are pleased to have received this orphan drug designation for RdCVF in the treatment of retinitis pigmentosa," said Bernard ...
Needleless Retinitis Therapy with FDA Approval of Oral CMV Drug | Treatment Action Group
Treatments for CMV retinitis are palliative rather than curative. Resistance to the FDA approved antivirals for CMV retinitis, ... The average CD4 count in persons with newly diagnosed CMV retinitis is below 30 cells/mm3. The main symptoms of CMV retinitis ... On February 27th the FDAs Antiviral Drugs Advisory Committee met to consider an application for approval of Hoffmann-La ... Cytomegalovirus (CMV) retinitis, a viral disease affecting the eyes and causing loss of vision, was once a rare disease ...
Retinitis Pigmentosa 23 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Retinitis Pigmentosa 81 Nonsyndromic Retinitis Pigmentosa Diseases related to Retinitis Pigmentosa 23 via text searches within ... Diseases in the Retinitis Pigmentosa family:. Retinitis Pigmentosa 1 Retinitis Pigmentosa 9 ... MalaCards integrated aliases for Retinitis Pigmentosa 23:. Name: Retinitis Pigmentosa 23 57 12 53 75 29 13 6 15 ... MalaCards based summary : Retinitis Pigmentosa 23, also known as rp23, is related to retinitis pigmentosa and leber congenital ...
Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa | IOVS | ARVO Journals
Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa ... Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa ... Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci ... Purpose: Retinitis pigmentosa (RP) is a group of hereditary retinal degeneration in which mutations commonly result in the ...
Retinitis Pigmentosa 2, X-Linked disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Retinitis Pigmentosa 2, X-Linked Diseases related to Retinitis Pigmentosa 2, X-Linked via text searches within MalaCards or ... MalaCards based summary : Retinitis Pigmentosa 2, X-Linked, also known as rp 2, is related to retinitis pigmentosa 2. An ... MalaCards integrated aliases for Retinitis Pigmentosa 2, X-Linked:. Name: Retinitis Pigmentosa 2, X-Linked 53 ... Diseases in the Retinitis Pigmentosa, Y-Linked family:. ... Retinitis Pigmentosa 2, X-Linked Categories: Rare diseases, Eye ...
Whole-organism HTS Identifies Synergistic Drug Combinations Promoting Rod Photoreceptor Survival in a Zebrafish Model of...
Purpose : Retinitis pigmentosa (RP) is caused by the death of rod photoreceptors. The purpose of this study was to use a whole- ... 2934 predominantly human-approved drugs). Each drug was tested across six concentrations (4µM - 125nM) and 16 fish per ... After a 4 hr pre-exposure to test drugs, larvae were exposed to 2.5 mM metronidazole to induce rod cell apoptosis. Surviving ... Methods : Transgenic zebrafish which enabled prodrug (metronidazole)-induced rod cell apoptosis were used to identify drugs ...
ReNeuron receives European and US Orphan Drug Designation for its retinal stem cell therapy candidate for treatment of...
"We are delighted to have received Orphan Drug Designation for our ReN003 stem cell therapy candidate for retinitis pigmentosa ... The therapy has been granted Orphan Drug Designation in both Europe and the US by the European Commission and the Food and Drug ... Orphan Drug Designation is typically granted to treatments that provide significant benefit to patients with rare diseases that ... The Company is targeting an initial Phase I/II clinical trial with ReN003 in the UK and the US, in retinitis pigmentosa ...
Retinitis Pigmentosa Guide: Causes, Symptoms and Treatment Options
Retinitis Pigmentosa - an easy to understand guide covering causes, diagnosis, symptoms, treatment and prevention plus ... Retinitis Pigmentosa. Medically reviewed by Drugs.com. Last updated on Feb 4, 2019. ... Drugs.com Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ... Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and ...
Frontiers | Microglia Mediate Synaptic Material Clearance at the Early Stage of Rats With Retinitis Pigmentosa | Immunology
Resident microglia are the main immune cells in the retina and play a key role in the pathogenesis of retinitis pigmentosa (RP ... Resident microglia are the main immune cells in the retina and play a key role in the pathogenesis of retinitis pigmentosa (RP ... Drug Administration. Control or RCS rats were fed a PLX3397-formulated AIN-76A diet (600 p.p.m; 600 mg PLX3397 (Selleckchem, ... Microglia Mediate Synaptic Material Clearance at the Early Stage of Rats With Retinitis Pigmentosa. Juncai He1,2, Congjian Zhao ...
Retinitis Pigmentosa - Pigmentary Retinopathy Summary Report | CureHunter
Retinitis Pigmentosa: Hereditary, progressive degeneration of the neuroepithelium of the retina characterized by night ... Drugs and Biologics. Drugs and Important Biological Agents (IBA) related to Retinitis Pigmentosa: 1. Retinaldehyde (Retinal)IBA ... Retinitis Pigmentosa (Pigmentary Retinopathy). Subscribe to New Research on Retinitis Pigmentosa Hereditary, progressive ... 05/01/1993 - "Long-term treatment of retinitis pigmentosa with acetazolamide. ". 01/01/1991 - "In the patients with retinitis ...
CMV Retinitis Differential Diagnoses
Design of clinical trials for drug combinations: cytomegalovirus retinitis--foscarnet and ganciclovir. The CMV retinitis ... Plosker GL, Noble S. Cidofovir: a review of its use in cytomegalovirus retinitis in patients with AIDS. Drugs. 1999 Aug. 58(2): ... Akerele T, Lightman S. Current and novel agents for the treatment of cytomegalovirus retinitis. Drugs R D. 1999 Nov. 2(5):289- ... Marwick C. First "antisense" drug will treat CMV retinitis. JAMA. 1998 Sep 9. 280(10):871. [Medline]. ...
Trial of Oral Valproic Acid for Retinitis Pigmentosa - Full Text View - ClinicalTrials.gov
Genetics Home Reference related topics: Retinitis pigmentosa Drug Information available for: Valproic acid Valproate sodium ... Retinitis. Retinitis Pigmentosa. Retinal Diseases. Eye Diseases. Eye Diseases, Hereditary. Retinal Dystrophies. Retinal ... Physiological Effects of Drugs. Antimanic Agents. Tranquilizing Agents. Central Nervous System Depressants. Psychotropic Drugs ... Trial of Oral Valproic Acid for Retinitis Pigmentosa (VPA). The safety and scientific validity of this study is the ...
Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa - Full Text View - ClinicalTrials.gov
Retinitis Pigmentosa Retinal Diseases Eye Diseases Eye Disease, Hereditary Retinal Degeneration Drug: Valproic Acid Phase 2 ... Has taken one of the following drugs at least 4 weeks prior to enrollment as these drugs are specifically known to affect the ... Retinitis. Retinitis Pigmentosa. Retinal Diseases. Retinal Degeneration. Genetic Diseases, Inborn. Eye Diseases, Hereditary. ... Physiological Effects of Drugs. Antimanic Agents. Tranquilizing Agents. Central Nervous System Depressants. Psychotropic Drugs ...
OU researchers find way to prevent blindness in research model for retinitis pigmentosa - ScienceBlog.com
The research on retinitis pigmentosa at the OU Health Sciences Center is supported by a grant from the National Eye Institute ... Its breathtaking, very exciting. Retinitis pigmentosa is an eye disease in which there is damage to the retina. The damage ... For more information on retinitis pigmentosa, go online to www.nlm.nih.gov/medlineplus/ency/article/001029.htm. ... the results of our study will be instrumental in generating a cure for the debilitating blindness associated with retinitis ...
Which clinical history findings are characteristic of cytomegalovirus retinitis in HIV infection?
Patients tend to have good vision at diagnosis of CMV retinitis. Often... more ... Patients with CMV retinitis typically complain of floaters, photopsias, or visual loss, without associated eye pain or ... Drugs & Diseases , Ophthalmology , Ocular Manifestations of HIV Infection Q&A Which clinical history findings are ... Patients with CMV retinitis typically complain of floaters, photopsias, or visual loss, without associated eye pain or ...
Retinitis Pigmentosa | A Pipeline Analysis Report 2018 | Technavio | Benzinga
Technavio has announced their latest pipeline analysis report on the retinitis pigmentosa market. The report includes a ... Technavio has published a new report on the drug development pipeline for retinitis pigmentosa, including a detailed study of ... Retinitis pigmentosa: Market overview Retinitis pigmentosa is a genetic disorder that results in vision loss.. It is known to ... Retinitis pigmentosa: Segmentation analysis This pipeline analysis report segments the retinitis pigmentosa market. based on ...
Eye Conditions - I have retinitis pigmentosa, would I be able to get Marinol prescribed?
... retinitis pigmentosa, vision - Answer: My first thought is that i hope you have good insurance, its ... ... Drugs.com Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ... Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and ... marinol, eye conditions, retinitis pigmentosa, vision. Details:. just been diagnosed over a month ago, now thats depressing, ...
Retinitis Pigmentosa Therapeutics Pipeline Analysis, 2017 - Clinical Trials & Results, Patent, Designations, Collaborations,...
Retinitis pigmentosa currently exhibits a growing pipeline with 38 drug candidates Retinitis Pigmentosa therapeutics pipeline ... Retinitis pigmentosa currently exhibits a growing pipeline with 38 drug candidates. Retinitis Pigmentosa therapeutics pipeline ... is a key driver for the development of pipeline drugs, for treating retinitis pigmentosa. Majority of the pipeline drug ... Based on molecule type, around 50.0% of the drug candidates in the retinitis pigmentosa pipeline are expected to be developed ...
CMV retinitis: MedlinePlus Medical Encyclopedia
... retinitis is a viral infection of the retina of the eye resulting in inflammation. ... This progression may happen because the virus becomes resistant to the antiviral drugs so the drugs are no longer effective, or ... CMV retinitis is caused by a member of a group of herpes-type viruses. Infection with CMV is very common. Most people are ... CMV retinitis may also lead to retinal detachment, in which the retina detaches from the back of the eye, causing blindness. ...
Retinitis pigmentosa - Wikipedia
"U.S. Food and Drug Administration. 19 December 2017. Retrieved 18 June 2020.. ... "Retinitis Pigmentosa".. *^ Zhao GY, Hu DN, Xia HX, Xia ZC (1995). "Chinese family with retinitis pigmentosa". Opthalamic ... Retinitis pigmentosa, late-onset dominant 300455 RPGR Retinitis pigmentosa, X-linked, and sinorespiratory infections, with or ... "Retinitis pigmentosa".. *^ Bujakowska, K.; Maubaret, C.; Chakarova, C. F.; Tanimoto, N.; Beck, S. C.; Fahl, E.; Humphries, M. M ...
Retinitis pigmentosa symptoms, treatments & forums | PatientsLikeMe
74 patients with retinitis pigmentosa experience fatigue, depressed mood, pain, anxious mood, and insomnia and use Hydrocodone- ... Acetaminophen, Buprenorphine patch, Fish Oil, and Physical Therapy to treat their retinitis pigmentosa and its symptoms. ... Find the most comprehensive real-world symptom and treatment data on retinitis pigmentosa at PatientsLikeMe. ... 5 retinitis pigmentosa patients report mild anxious mood (20%). * 10 retinitis pigmentosa patients report no anxious mood (40%) ...
An Open-Label Safety Study of Oral Ganciclovir Maintenance Treatment of CMV Retinitis in People With Limited Venous Access |...
ClinicalTrials.gov summary of An Open-Label Safety Study of Oral Ganciclovir Maintenance Treatment of CMV Retinitis in People ... Patients enrolled at time of closure of enrollment will receive 2 months of study drug and undergo follow-up. ... Retinitis Cytomegalovirus Retinitis Ganciclovir Ganciclovir triphosphate ClinicalTrials.gov processed this data on October 18, ... Retinitis Ganciclovir Administration, Oral Acquired Immunodeficiency Syndrome Additional relevant MeSH terms: HIV Infections ...
Therapeutic potential of valproic acid for retinitis pigmentosa | British Journal of Ophthalmology
Improved Treatment of CMV Retinitis - TheBody.com
Neither drug offers an advantage in efficacy for treating CMV retinitis, but they have different side-effects profiles. The ... Improved Treatment of CMV Retinitis. New Drugs and New Strategies Can Inhibit Disease Progression ... Parenteral cidofovir for cytomegalovirus retinitis in patients with AIDS: the HPMPC peripheral cytomegalovirus retinitis trial ... "Several novel anti-CMV drugs are currently undergoing clinical trial. These experimental agents include a valine ester of ...
Gene Therapy and Optogenetic Goggles for Retinitis Pigmentosa. Interview with Dr. Bernard Gilly, CEO of GenSight Biologics |...
Bernard Gilly: There are two main components to the therapeutic approach: one is a drug product (DP), the second is a wearable ... Medgadget: Does the gene therapy target the specific mutations that causes retinitis pigmentosa? If not, how does it work? ... Conn Hastings received a PhD from the Royal College of Surgeons in Ireland for his work in drug delivery, investigating the ... Conn Hastings, Medgadget: Can you give us some background on retinitis pigmentosa and the current lack of treatments? ...
PigmentosaClinical trialsTargeting retinitis pigmentosaAutosomal dominant retinitisAssociated with retinitis pigmentosaCaused by retinitis pigmentosaPatients with cytomegalovirus retinitisVisual acuityDiagnosisAvailable for curing retinitis pigKnown to cause retinitis pigmentosaImplant for treating cytomegalovirusTherapeuticsCure for retinitis pigmentosaIntravenousAbstractInfectionValproic AcidGeneticClinicalADRPPeople with CMV retinitisTreatments for CMV retinitisProgression of CMV retinitisHereditaryTypical retinitis pigmentosa2016MacularLesionsGeneInfectionsGenesExudative retinitisFloatersPneumonitisTherapyValganciclovirEfficacyUsherIntraocularCongenital amaurosis
- Results show the Argus II prosthesis provides visual function to patients with end-stage retinitis pigmentosa. (asrs.org)
- Buy the retinitis pigmentosa GTPase regulator biomarker report now and get immediate access to all of the clinical uses of retinitis pigmentosa GTPase regulator including 0 clinical trials where retinitis pigmentosa GTPase regulator is being measured across 287 conditions. (biomarkerbase.com)
Targeting retinitis pigmentosa1
- ReNeuron is using its proprietary human retinal progenitor cells as the basis of its ReN003 therapeutic candidate targeting retinitis pigmentosa, a group of hereditary diseases of the eye that lead to progressive loss of sight due to cells in the retina becoming damaged and eventually dying. (reneuron.com)
Autosomal dominant retinitis13
- The objectives of this study are to evaluate the efficacy of Valproic Acid (VPA) to both slow the progression of visual function loss and/or to restore visual function in patients with Autosomal Dominant Retinitis Pigmentosa (RP) and to collect safety and tolerability information. (clinicaltrials.gov)
- Mutations in the visual pigment protein rod opsin are the most common cause of autosomal dominant retinitis pigmentosa (ADRP) and the majority of these mutations lead to the misfolding of the protein. (bl.uk)
- QR-1123 is a first-in-class investigational antisense oligonucleotide designed to address the underlying cause of vision loss associated with autosomal dominant retinitis pigmentosa (adRP) due to the P23H mutation in the rhodopsin ( RHO ) gene. (proqr.com)
- We are pleased to have orphan drug designation for our QR-1123 program targeting autosomal dominant retinitis pigmentosa, or adRP," said Daniel de Boer, Chief Executive Officer of ProQR. (proqr.com)
- Autosomal dominant retinitis pigmentosa, or adRP, is a severe and rare genetic disease that causes progressive problems in night vision during childhood, leading to visual field loss and frequently resulting in blindness in mid adulthood. (proqr.com)
- ProQR Therapeutics is dedicated to changing lives through the creation of transformative RNA medicines for the treatment of severe genetic rare diseases such as Leber's congenital amaurosis 10, Usher syndrome and autosomal dominant retinitis pigmentosa. (proqr.com)
- 2006) Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis. (guidetopharmacology.org)
- researchers have identified X-linked , autosomal recessive , and autosomal dominant retinitis pigmentosa types. (rxlist.com)
- Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa. (sigmaaldrich.com)
- Autosomal dominant retinitis pigmentosa (adRP) is a heterogeneous set of progressive retinopathies caused by several distinct genes. (sigmaaldrich.com)
- QR-1123, a first-in-class investigational antisense oligonucleotide for the treatment of vision loss associated with autosomal dominant retinitis pigmentosa, received an orphan drug designation from the FDA. (healio.com)
- Ophthotech Corporation announced today that scientists at the University of Pennsylvania and University of Florida published proof-of-concept study results on an adeno-associated virus gene therapy product candidate for the treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa licensed by Ophthotech. (news-medical.net)
- Scientists funded by the National Eye Institute report a novel gene therapy that halts vision loss in a canine model of a blinding condition called autosomal dominant retinitis pigmentosa (adRP). (news-medical.net)
Associated with retinitis pigmentosa4
- An important gene associated with Retinitis Pigmentosa 23 is OFD1 (OFD1, Centriole And Centriolar Satellite Protein). (malacards.org)
- An important gene associated with Retinitis Pigmentosa 2, X-Linked is RP2 (RP2, ARL3 GTPase Activating Protein). (malacards.org)
- We hope the results of our study will be instrumental in generating a cure for the debilitating blindness associated with retinitis pigmentosa and other inherited and acquired retinal diseases. (scienceblog.com)
- Genetic tests can identify genes associated with retinitis pigmentosa. (rxlist.com)
Caused by retinitis pigmentosa1
Patients with cytomegalovirus retinitis6
- Evaluation of the United States public health service guidelines for discontinuation of anticytomegalovirus therapy after immune recovery in patients with cytomegalovirus retinitis. (medscape.com)
- Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy. (medscape.com)
- Rhegmatogenous retinal detachment in patients with cytomegalovirus retinitis: the Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial. (medscape.com)
- Risk of vision loss in patients with cytomegalovirus retinitis and the acquired immunodeficiency syndrome. (thefreedictionary.com)
- Cytomegalovirus resistance to ganciclovir and clinical outcomes of patients with cytomegalovirus retinitis. (wikipedia.org)
- IRU is the most common form of immune reconstitution inflammatory syndrome in HIV-infected patients with cytomegalovirus retinitis who are receiving highly active antiretroviral therapy (HAART). (hindawi.com)
- Effect of cytomegalovirus retinitis on the risk of visual acuity loss among patients with AIDS. (medscape.com)
- Eliot L. Berson, M.D ., of the Massachusetts Eye and Ear, and Harvard Medical School, and colleagues analyzed visual acuity data from three clinical trials conducted involving patients with typical retinitis pigmentosa from 1984 to 1991, 1996 to 2001 and 2003 to 2008. (healthcanal.com)
- Therefore, the treatment regimen of vitamin A combined with an ω-3-rich diet (≥0.20 g/d) should make it possible for many patients with typical retinitis pigmentosa to retain both visual acuity and central visual field for most of their lives," the researchers conclude. (healthcanal.com)
- To confirm a diagnosis of retinitis pigmentosa, an ophthalmologist may do an electroretinogram (ERG). (drugs.com)
- Polymerase chain reaction-based assays of vitreous samples for the diagnosis of viral retinitis. (medscape.com)
- Patients tend to have good vision at diagnosis of CMV retinitis. (medscape.com)
- The diagnosis of cytomegalovirus retinitis, as well as the evaluation of its response to therapy, is determined primarily by clinical criteria. (annals.org)
- For each diagnosis, appropriate drug choices are listed alphabetically by generic name, with updated info on FDA pregnancy categories, generic and over-the-counter availability, pediatric dosing regimens, brand names, dose forms, contraindications, and more. (springerpub.com)
- Within each diagnosis, appropriate drug choices are listed by generic name, with FDA pregnancy category, generic or over-the-counter availability, adult/pediatric dosing regimens, brand names, dose forms, and information regarding additives. (springerpub.com)
- This report is classified into eleven sections - Retinitis Pigmentosa overview including etiology, pathophysiology, and diagnosis, Retinitis Pigmentosa treatment options, Retinitis Pigmentosa pipeline products, Retinitis Pigmentosa market analysis globally and by each country. (researchandmarkets.com)
Available for curing retinitis pig1
Known to cause retinitis pigmentosa1
Implant for treating cytomegalovirus1
- Use of the ganciclovir implant for treating cytomegalovirus retinitis secondary to immunosuppression after bone marrow transplantation. (medscape.com)
- The study analyzed that the retinitis pigmentosa therapeutics pipeline comprises approximately 38 drug candidates in different stages of development. (reportbuyer.com)
- HORAMA S.A. is in the process of developing two phase I/II, and one Pre-Clinical therapeutics for the treatment of retinitis pigmentosa. (reportbuyer.com)
- Some of the key players developing drugs for the treatment of retinitis pigmentosa include jCyte, Inc., Dompe Farmaceutici SpA, ProRetina Therapeutics, S.L., and Recursion Pharmaceuticals Inc. (reportbuyer.com)
- The global retinitis pigmentosa market is treading towards growth in a slow manner owing to the unavailability of therapeutics to cure this rare disease. (medgadget.com)
- LEIDEN, Netherlands and CAMBRIDGE, Mass., Nov. 21, 2019 (GLOBE NEWSWIRE) -- ProQR Therapeutics N.V. (Nasdaq:PRQR), a company dedicated to changing lives through the creation of transformative RNA medicines for severe genetic rare diseases, today announced that it received Orphan Drug designation (ODD) from the Food and Drug Administration ( FDA ) for QR-1123. (proqr.com)
- CLEVELAND--(BUSINESS WIRE)--Jun 4, 2007 - Copernicus Therapeutics, Inc. announced today that a research team at University of Oklahoma Health Sciences Center, led by Dr. Muna Naash, Professor of Cell Biology, demonstrated that Copernicus' DNA nanoparticles corrected vision defects in a mouse model of retinitis pigmentosa (RP). (bio-medicine.org)
- ANN ARBOR, Mich.--( BUSINESS WIRE )--RetroSense Therapeutics LLC, a privately-held biopharmaceutical company, today announced the Company's Investigational New Drug (IND) application for RST-001 received clearance from the United States Food and Drug Administration (FDA). (businesswire.com)
- RetroSense Therapeutics announced an Investigational New Drug (IND) application for RST-001 received clearance from the FDA. (businesswire.com)
- Oral ganciclovir is an alternative to the intravenous formulation for the maintenance treatment of CMV retinitis. (clinicaltrials.gov)
- Were the year 1997, the FDA would approve valganciclovir solely on pharmacokinetic data demonstrating that a 900mg daily (oral) dose of valganciclovir produced comparable drug exposure (area under the curve/AUC) to that of the standard daily intravenous ganciclovir dose of 5mg/kg. (treatmentactiongroup.org)
- To provide oral ganciclovir to patients who require maintenance for control of cytomegalovirus (CMV) retinitis, but who lack patent permanent central venous access for long-term administration of intravenous drugs. (nih.gov)
- The daily intravenous infusions that were once required to slow the progression of CMV retinitis exacted a heavy toll, both in dollars and in quality of life, and patients were justly apprehensive about beginning infusion therapy. (thebody.com)
- IVDU, intravenous drug use. (cdc.gov)
- The intraocular sustained-release ganciclovir implant proved to be a safe new procedure for the treatment of CMV retinitis, avoiding the systemic side effects caused by the intravenous medications and improving the quality of life of the patients. (scielo.br)
- To improve the treatment andquality of life for these people, researchers have sought alternativetherapies for CMV retinitis, such as the ganciclovir implant, thatwould prove safe and effective and spare them the daily inconvenienceof intravenous treatment. (nih.gov)
- Ganciclovir capsules are used to treat CMV retinitis after the condition has been controlled by intravenous (injected into a. (ebscohost.com)
- The purpose of the present study was to examine the emergence of ganciclovir-resistant virus in the contralateral eyes of patients who received treatment for cytomegalovirus retinitis with either a ganciclovir implant plus oral placebo, a ganciclovir implant plus oral ganciclovir, or intravenous. (ebscohost.com)
- The purpose of this study is to make valganciclovir available, before it is approved for marketing, to HIV-infected patients who have cytomegalovirus (CMV) retinitis (eye infection) and cannot take drugs by injection. (clinicaltrials.gov)
- Which clinical history findings are characteristic of cytomegalovirus retinitis in HIV infection? (medscape.com)
- suppurative retinitis retinitis due to pyemic infection. (thefreedictionary.com)
- Cytomegalovirus retinitis (CMVR) is the most frequent opportunistic eye infection in patients with HIV infection. (bmj.com)
- Our findings suggest that the combination of proteaseinhibitors and other anti-HIV medications can restore the immunesystem to a point where it can fight the CMV retinitis infection onits own," said Dr. Scott Whitcup, clinical director of NEI andfirst author of the JAMA letter. (nih.gov)
- CMV retinitis is a chronic, sight-threatening infection of theretina, the light-sensing tissue that lines the back of the eye. (nih.gov)
- The purpose of this study is to evaluate the efficacy and safety of oral valproic acid to slow the progression of visual function and/or to improve the visual function in patients with retinitis pigmentosa (RP). (clinicaltrials.gov)
- Background/aim To examine the efficacy and safety of valproic acid (VPA) in patients with retinitis pigmentosa (RP). (bmj.com)
- Retinitis pigmentosa is a genetic disorder that results in vision loss. (benzinga.com)
- Retinitis pigmentosa ( RP ) is a genetic disorder of the eyes that causes loss of vision . (wikipedia.org)
- In addition to the promise of providing corrective therapy for genetic diseases such as retinitis pigmentosa, nucleic acid nanoparticles may also offer the potential to provide effective treatments for more complex disorders such as diabetic retinopathy, macular degeneration, and various diseases that injure ganglion cells and the optic nerve. (bio-medicine.org)
- Research for a new treatment for retinitis pigmentosa (RP), a genetic disease affecting an average of one person every 3,500-5,000 is currently being carried out in Italy. (abdo.org.uk)
- Instead, the agency required the sponsor to conduct a randomized controlled clinical trial demonstrating equivalence between valganciclovir and IV ganciclovir for induction therapy of CMV retinitis. (treatmentactiongroup.org)
- The Company is targeting an initial Phase I/II clinical trial with ReN003 in the UK and the US, in retinitis pigmentosa patients, with clinical trial applications expected to be filed in the middle part of 2014. (reneuron.com)
- Many companies are increasingly emphasizing on the development of gene therapy candidates, due to their positive clinical results in the treatment of retinitis pigmentosa. (reportbuyer.com)
- Therefore, it is crucial that pharmaceutical companies minimize late-stage product failures, including unexpected neurotoxic effects, that can arise when candidate drugs enter the clinical testing stages. (prnewswire.com)
- All 39 eyes of the 26 patients presented healing of retinitis as shown by clinical improvement evaluated by indirect binocular ophthalmoscopy and retinography. (scielo.br)
- Retinitis healed within a period of 4 to 6 weeks in all patients, with clinical regression signs from the third week on. (scielo.br)
- We have published hundreds of Mutation Screening USH2A Gene Retinitis Pigmentosa USHER Patients news stories on BioPortfolio along with dozens of Mutation Screening USH2A Gene Retinitis Pigmentosa USHER Patients Clinical Trials and PubMed Articles about Mutation Screening USH2A Gene Retinitis Pigmentosa USHER Patients for you to read. (bioportfolio.com)
- In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Mutation Screening USH2A Gene Retinitis Pigmentosa USHER Patients Companies in our database. (bioportfolio.com)
- There are several forms of retinitis pigmentosa with different inheritance patterns, clinical signs, and visual symptoms. (rxlist.com)
- As such, it represents a standardised, clinical and commercial-grade cell therapy product capable of treating all eligible patients presenting with the diseases targeted, without the need for additional immunosuppressive drug treatments. (reneuron.com)
- Retinitis pigmentosa is a great challenge for ophthalmology, because it is a disease which still has no cure", explains Francesca Simonelli, director of clinical ophthalmology at the Second University of Naples. (abdo.org.uk)
- The extension was based on clinical trial randomized 326 high-risk kidney allograft patients to 100 days of drug treatment (at 900 mg a day) followed by 100 days of either placebo or continued active therapy. (medpagetoday.com)
People with CMV retinitis2
- Some people with CMV retinitis have no symptoms. (medlineplus.gov)
- This discovery is significant because it suggests that, undercertain circumstances, people with CMV retinitis can stop takingstandard anti-CMV medications and the disease would not progress,"said Dr. Carl Kupfer, director of the National Eye Institute, one ofthe Federal government's National Institutes of Health (NIH). (nih.gov)
Treatments for CMV retinitis2
Progression of CMV retinitis1
- Retinitis pigmentosa (RP) is a group of hereditary retinal degeneration in which mutations commonly result in the initial phase of rod cell death followed by gradual cone cell death. (arvojournals.org)
- Retinitis pigmentosa (RP) represents a group of retinal diseases typically attributed to hereditary factors that are caused by mutations predominantly expressed in photoreceptors or retinal pigment epithelial (RPE) cells, that contribute to rod degeneration followed by gradual death of cones ( 1 ). (frontiersin.org)
- retinitis pigmento´sa a group of diseases, frequently hereditary, marked by progressive loss of retinal response (as recorded by the electroretinograph ), retinal atrophy, attenuation of retinal vessels, and clumping of the pigment, with contraction of the field of vision. (thefreedictionary.com)
- Retinitis pigmentosa ( RP ) represents a group of hereditary progressive retinal disorders. (rxlist.com)
Typical retinitis pigmentosa1
- The latest research Global Retinitis Pigmentosa Market and Competitive Landscape Highlights - 2016, provides comprehensive insights into Retinitis Pigmentosa pipeline products, Retinitis Pigmentosa epidemiology, Retinitis Pigmentosa market valuations and forecast, Retinitis Pigmentosa products and competitive landscape. (researchandmarkets.com)
- Retinitis pigmentosa (RP) and age-related macular degeneration (AMD) are degenerative blinding diseases caused by the death of rods and cones, leaving the remainder of the visual system intact but largely unable to respond to light. (nih.gov)
- We present a case of retinitis pigmentosa (RP) related cystoid macular edema (CME) refractory to oral acetazolamide and topical ketorolac that was treated with intravitreal and subtenon depot triamcinolone. (hindawi.com)
- In heavily immunosuppressed individuals with CMV retinitis, lifelong maintenance therapy is recommended in order to the hold lesions at a quiescent state. (treatmentactiongroup.org)
- Over time, the lesions of CMV retinitis may coalesce with a full-thickness retinal whitening often associated with intraretinal hemorrhage. (medscape.com)
- On retinal examination, we found active retinitis lesions (cream-colored lesions associated with hemorrhages) and perivascular cuffing in the retinal periphery in the right eye. (hindawi.com)
- 12 A retinitis pigmentosa that has material basis in mutation in the OFD1 gene on chromosome Xp22. (malacards.org)
- Search GEO for disease gene expression data for Retinitis Pigmentosa 2, X-Linked. (malacards.org)
- Around 61% of the molecules that are being investigated for the treatment of retinitis pigmentosa are gene therapy. (benzinga.com)
- Based on molecule type, around 50.0% of the drug candidates in the retinitis pigmentosa pipeline are expected to be developed based on gene therapy. (reportbuyer.com)
- Gene Therapy and Optogenetic Goggles for Retinitis Pigmentosa. (medgadget.com)
- Here you can see the latest Mutation Screening USH2A Gene Retinitis Pigmentosa USHER Patients articles that have been published worldwide. (bioportfolio.com)
- You can also find out about relevant Mutation Screening USH2A Gene Retinitis Pigmentosa USHER Patients Drugs and Medications on this site too. (bioportfolio.com)
- Myoclonus epilepsy, retinitis pigmentosa, leukoencephalopathy and cerebral calcifications associated with a novel m.5513G>A mutation in the MT-TW gene. (bioportfolio.com)
- A Puerto Rican patient with X-linked retinitis pigmentosa (XLRP) is hoping to save his vision after an innovative gene therapy procedure at Bascom Palmer Eye Institute at the University of Miami Miller School of Medicine. (news-medical.net)
- Report Scope: The report focuses on select drugs (antimicrobials), environment treatment (disinfectants, sterilization systems etc.) and provisions in medical devices (e.g. catheters, patient ventilation devices, sterile IV filters) that prevent occurrence of nosocomial infections. (reportbuyer.com)
- Depression of cell-mediated immunity due to immunodeficiency syndromes or secondary to immunosuppressive medications predisposes to symptomatic CMV infections such as retinitis, encephalitis, hepatitis, pneumonitis, and myocarditis [ 3 ]. (hindawi.com)
- In bone marrow transplant recipients, however, there is a much greater incidence of CMV pneumonitis than retinitis. (treatmentactiongroup.org)
- The increasing number of organ and medulla transplants and an increase in the use of immunosuppressants were associated with the presence of pneumonitis, colitis, hepatitis, encephalitis, retinitis and other diseases due to CMV in these patients. (scielo.br)
- Guildford, UK, 29 August 2013: ReNeuron is pleased to announce that its ReN003 retinal stem cell therapy candidate for retinitis pigmentosa has achieved a significant regulatory milestone. (reneuron.com)
- Cytomegalovirus Retinitis in the Era of Highly Active Antiretroviral Therapy. (medscape.com)
- Cytomegalovirus retinitis after the initiation of highly active antiretroviral therapy: a 2 year prospective study. (medscape.com)
- ( 1 , 2 ) Moreover, recent reports indicate that some patients with established CMV retinitis -- a disease that previously could be slowed or checked only by daily IV infusions, and that progressed whenever therapy was interrupted for more than a few weeks -- were able to stop their anti-CMV therapy for up to a year without ill effect, once they began combination antiretroviral therapy. (thebody.com)
- Monitor renal function during therapy with CYTOVENE-IV, particularly in elderly patients and in patients taking other nephrotoxic drugs, and reduce dosage in patients with renal impairment. (nih.gov)
- Three of seven who received no specific therapy improved after decreasing dosages of immunosuppressive drugs. (annals.org)
- In here we described cytomegalovirus retinitis (CMVR) in 12-year-old male patient with acute lymphoblastic leukemia (ALL) who was on maintenance phase therapy. (hindawi.com)
- This new drug therapy may lead to asignificant improvement in the quality of life for people with AIDSwho have CMV retinitis. (nih.gov)
- When the dust had cleared, the agency's Antiviral Drug Advisory Committee had moved toward dethroning both AZT as the centerpiece of first line anti-HIV therapy and CD4 cell counts as the main lab standard for judging drug effectiveness. (thebody.com)
- Even after accessing care, persons may develop OIs because of lack of prescription for prophylaxis, antiretroviral drug resistance, or poor adherence to therapy. (cdc.gov)
- Intravitreal Ganciclovir Injections for Cytomegalovirus Retinitis in Acquired Immune Deficiency Syndrome Patients on Highly Active Antiretroviral Therapy. (ebscohost.com)
- Several classes of drugs are known to affect IMPDH isoenzymes, including nucleotide and NAD analogs, suggesting that small-molecule therapy may be available, one day, for RP10 patients. (sigmaaldrich.com)
- An experimental drug, valganciclovir , is similar to 1 of these approved drugs, ganciclovir, but is more convenient and easier to use since it can be taken by mouth. (clinicaltrials.gov)
- Roche WV 15376 was the sponsor's registrational study which evenly randomized 160 individuals with CMV retinitis to receive valganciclovir (900mg, orally, twice daily for 3 weeks followed by 900mg daily for 1 week) or IV ganciclovir (5mg/kg twice daily for 3 weeks followed by 5mg/kg daily for 1 week). (treatmentactiongroup.org)
- Valganciclovir is an antiviral agent, prescribed for cytomegalovirus (CMV) retinitis. (medindia.net)