Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.Mechlorethamine: A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.Lomustine: An alkylating agent of value against both hematologic malignancies and solid tumors.Vincristine: An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Oligodendroglioma: A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.Bleomycin: A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Dacarbazine: An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Nimustine: Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.Leukemia L1210Hexestrol: A synthetic estrogen that has been used as a hormonal antineoplastic agent.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Mitolactol: Alkylating antineoplastic toxic to bone marrow; used in breast cancer, also in combination with other drugs.Cercopithecus: A genus of Old World monkeys found in Africa although some species have been introduced into the West Indies. This genus is composed of at least twenty species: C. AETHIOPS, C. ascanius, C. campbelli, C. cephus, C. denti, C. diana, C. dryas, C. erythrogaster, C. erythrotis, C. hamlyni, C. lhoesti, C. mitis, C. mona, C. neglectus, C. nictitans, C. petaurista, C. pogonias, C. preussi, C. salongo, and C. wolfi.Central Nervous System Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.Nitrosourea CompoundsGlioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)Seminiferous Tubules: The convoluted tubules in the TESTIS where sperm are produced (SPERMATOGENESIS) and conveyed to the RETE TESTIS. Spermatogenic tubules are composed of developing germ cells and the supporting SERTOLI CELLS.Chromosomes, Human, Pair 19: A specific pair of GROUP F CHROMOSOMES of the human chromosome classification.Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)Actuarial Analysis: The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.Buserelin: A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.Antineoplastic Agents, Alkylating: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)Karnofsky Performance Status: A performance measure for rating the ability of a person to perform usual activities, evaluating a patient's progress after a therapeutic procedure, and determining a patient's suitability for therapy. It is used most commonly in the prognosis of cancer therapy, usually after chemotherapy and customarily administered before and after therapy. It was named for Dr. David A. Karnofsky, an American specialist in cancer chemotherapy.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Chromosomes, Human, Pair 1: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Spermatogenesis: The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Vindesine: Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Fertility: The capacity to conceive or to induce conception. It may refer to either the male or female.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.Radiotherapy: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.Spermatogonia: Euploid male germ cells of an early stage of SPERMATOGENESIS, derived from prespermatogonia. With the onset of puberty, spermatogonia at the basement membrane of the seminiferous tubule proliferate by mitotic then meiotic divisions and give rise to the haploid SPERMATOCYTES.
... and procarbazine, a chemotherapy drug. DEAD is an orange-red liquid which weakens its color to yellow or colorless upon ... It is used in the synthesis of various natural products and pharmaceuticals such as zidovudine, an AIDS drug; FdUMP, a potent ... an important antiviral drug, used among others in the treatment of AIDS. Another example of pharmaceutical application of DEAD- ...
Chemotherapies with high risk include procarbazine and alkylating drugs such as cyclophosphamide, ifosfamide, busulfan, ... Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and carboplatin. On the other hand, therapies ...
Chemotherapies with high risk include procarbazine and other alkylating drugs such as cyclophosphamide, ifosfamide, busulfan, ... drug-to-drug interactions, genetics, and obesity, which has a major impact on the actual concentration of the drug in the ... can occur which prevent the drugs from binding to the protein, leading to resistance to these types of drugs. Drugs used in ... The first chemotherapy drug to be developed from this line of research was mustine. Since then, many other drugs have been ...
... (TMZ; brand names Temodar and Temodal and Temcad) is an oral chemotherapy drug. It is an alkylating agent used as ... Nitrosourea- and procarbazine-refractory anaplastic astrocytoma Newly diagnosed glioblastoma multiforme The most common side ... Chemotherapy Drug Shrinks Brain Tumors American Academy of Neurology, May 21, 2007 Information for people undergoing treatment ... Lactating women should discontinue nursing while receiving the drug because of the risk of secretion into breast milk. One ...
The molecular formula C12H19N3O (molar mass: 221.29 g/mol) may refer to: Procarbazine, a drug against cancer Alchorneine, an ...
Chemotherapies with high risk of infertility include procarbazine and other alkylating drugs such as cyclophosphamide, ... Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and carboplatin. On the other hand, therapies ...
The drug was initially marketed by Bayer. Bayer continues to supply DTIC-Dome. There are also generic versions of dacarbazine ... Dacarbazine was proven to be just as efficacious as procarbazine in the German trial for paediatric Hodgkin's lymphoma, without ... Like many chemotherapy drugs, dacarbazine may have numerous serious side effects, because it interferes with normal cell growth ... "Dacarbazine". International Drug Price Indicator Guide. Retrieved 8 December 2016. British national formulary : BNF 69 (69 ed ...
Chemotherapies with high risk include procarbazine and other alkylating drugs such as cyclophosphamide, ifosfamide, busulfan, ... Antibody-drug conjugates[edit]. Antibody-drug conjugates (ADCs) comprise an antibody, drug and a linker between them. The ... drug-to-drug interactions, genetics, and obesity, which has a major impact on the actual concentration of the drug in the ... can occur which prevent the drugs from binding to the protein, leading to resistance to these types of drugs.[117] Drugs used ...
The abbreviation stands for the four drugs Adriamycin, bleomycin, vinblastine, and dacarbazine. Developed in Italy in the 1970s ... MSD and VCR are administered intravenously, while procarbazine and prednisone are pills taken orally. MOPP was the first ... The abbreviation stands for the four drugs Mustargen (also known as chlormethine), Oncovin (also known as vincristine), ... Prednisone and Procarbazine (also known as Matulane). The treatment is usually administered in four week cycles, often for six ...
The acronym is derived from the component drugs of the regimen: (M)ustargen (also known as mechlorethamine, chlormethine, ... MSD and VCR are administered intravenously, while procarbazine and prednisone are pills taken orally. A newer Hodgkin's ...
Cladribine and clofarabine are two other drugs being investigated in MCL. A relatively new regimen that uses old drugs is PEP-C ... which includes relatively small, daily doses of prednisone, etoposide, procarbazine, and cyclophosphamide, taken orally, has ... MCL cells may also be resistant to drug-induced apoptosis, making them harder to cure with chemotherapy or radiation. Cells ... something that he and his colleagues are testing through an ongoing drug trial. Another approach involves using very high doses ...
... procarbazine, mechlorethamine Co-administration of the following drugs may make allopurinol less active or decrease its half- ... Giving allopurinol with either of these drugs at their normal dose will lead to overdose of either drug; only one-quarter of ... "Allopurinol Use During Pregnancy , Drugs.com". www.drugs.com. Archived from the original on 20 August 2016. Retrieved 20 ... Drug Discovery: A History. John Wiley & Sons, 2005 ISBN 9780471899792. page 254 Archived 2016-06-10 at the Wayback Machine. ...
... an oral antifungal drug Procarbazine Temposil, or citrated calcium carbimide, has the same function as disulfiram, but is ... "Disulfiram Side Effects". Drugs.com. Retrieved 6 November 2010. Cornford, E M; Bocash, W D; Braun, L D; Crane, P D; Oldendorf, ... Disulfiram (sold under the trade names Antabuse and Antabus) is a drug used to support the treatment of chronic alcoholism by ... Methods to improve compliance include subdermal implants, which release the drug continuously over a period of up to 12 weeks, ...
Synthetic drugs Hydroxyurea (Hydrea) (1967) Procarbazine (Matulane) (1969) O, P'-DDD (Lysodren, Mitotane) (1970) Dacarbazine ( ... The NCI played an early role in the discovery of anti-cancer drugs in the U.S. According to a 1996 NCI analysis of drugs ... two-thirds of the anti-cancer drugs approved as of the end of 1995 were NCI-sponsored Investigational New Drugs: Alkylating ... It also tells if there is any unique response of the drug which is not similar to any of the standard prototype compounds in ...
... or procarbazine, of which were usually added one at a time to the corticosteroid until a successful combination was found. ... the basic treatment was some type of corticosteroid in combination with one or more immunosuppressive drugs, typically cytosine ...
... but is now being superseded by a newer drug: Temozolomide. Temozolomide is a common chemotherapeutic drug to which ... PCV chemotherapy (Procarbazine, CCNU and Vincristine) has been shown to be effective and was the most commonly used ... However, different dosing schedules may produce better results, such as continuous daily dosing using lower amounts of drug (e. ... especially because of its relatively mild side effects when compared to other chemotherapeutic drugs. Nevertheless, a ...
Cancer cells could conceivably mutate to become resistant to a single agent, but by using different drugs concurrently it would ... procarbazine and prednisone, known as the MOPP regimen, could cure patients with Hodgkin's and non-Hodgkin's lymphoma. ... Currently, nearly all successful cancer chemotherapy regimens use this paradigm of multiple drugs given simultaneously, called ... Holland hypothesized that cancer could best be treated by combinations of drugs, each with a different mechanism of action. ...
Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: ... procarbazine, and prednisone 1965 - MOMP regimen combination therapy, consisting of: methotrexate, vincristine, 6-MP, and ... From Traditional Medicines to Modern Drugs Chemotherapy Treatment of Solid Tumor Cancers with the Chemotherapy Drug ... "Tamoxifen-like drug suggests new ways to selectively block estrogen". "Centre of laser medicine - Historical Aspects of ...
Other drugs that contribute to serotonin syndrome include MAO inhibitors, linezolid, tedizolid, methylene blue, procarbazine, ... Milnacipran's lack of drug-drug interactions via cytochrome P450 enzymes is thought to be an attractive feature because many of ... Symptoms of SNRI overdose, whether it be a mixed drug interaction or the drug alone, vary in intensity and incidence based on ... Overdosing on SNRIs can be caused by either drug combinations or excessive amounts of the drug itself. Venlafaxine is ...
Metfendrazine Nialamide Octamoxin Paraxazone Phenelzine Pheniprazine Phenoxypropazine Pivalylbenzhydrazine Procarbazine ... This is a list of adrenergic drugs. These are pharmaceutical drugs, naturally occurring compounds and other chemicals that ...
Procarbazine • Safrazine • Tranylcypromine MAO-A selective: Amiflamine • Bazinaprine • Befloxatone • Befol • Brofaromine • ... This is a list of dopaminergic drugs. These are pharmaceutical drugs, naturally occurring compounds and other chemicals that ...
These drugs are sometimes used with ABVD to prevent neutropenia (low white blood cell count) and anemia related to the ... This combination of mechlorethamine, vincristine (Oncovin), procarbazine, and prednisone proved capable of curing almost 70% of ... It consists of concurrent treatment with the chemotherapy drugs: (A)driamycin (also known as doxorubicin/(H)ydroxydaunorubicin ... All four of the chemotherapy drugs are given intravenously. ABVD chemotherapy is usually given in the outpatient setting - that ...
Procalamine Procan Procanbid Procapan procarbazine (INN) Procardia procaterol (INN) prochlorperazine (INN) procinolol (INN) ... Many drugs have more than one name and, therefore, the same drug may be listed more than once. Brand names and generic names ... See also the list of the top 100 bestselling branded drugs, ranked by sales. Abbreviations are used in the list as follows: INN ... This multi-page article lists pharmaceutical drugs alphabetically by name. ...
Medline Plus Drug Information MOPP Treatment Regimen PCV Information Procarbazine Drug Information Provided by Lexi-Comp - ... Procarbazine is in the alkylating agents family of medication. How it works is not clearly known. Procarbazine was approved for ... and procarbazine. The first combination chemotherapy developed for Hodgkin's lymphoma (HL), MOPP also included procarbazine ( ... Procarbazine is a chemotherapy medication used for the treatment of Hodgkin's lymphoma and brain cancers. For Hodgkin's it is ...
Etacrynic acid Griseofulvin Hydrazines such as isoniazid and procarbazine Ketoconazole Macrolide immunosuppressants such as ... A disulfiram-like drug is a drug that causes hypersensitivity to the unpleasant and toxic effects of alcohol. Such effects may ... A variety of other drugs cause disulfiram-like reactions upon consumption of alcohol as unintended drug interactions and side ... Many disulfiram-like drugs act as inhibitors of acetaldehyde dehydrogenase similarly to disulfiram. However, some do not act ...
Procarbazine • Safrazine • Tranylcypromine; MAO-A Selective: Amiflamine • Bazinaprine • Befloxatone • Befol • Brofaromine • ... proc, drug(A2A/2B/3/4/5/6/7/14/16), blte ...
Procarbazine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking procarbazine,. *tell your doctor and pharmacist if you are allergic to procarbazine, any other medications, or ... If you become pregnant while receiving procarbazine, call your doctor. Procarbazine may harm the fetus. ... Procarbazine comes as a capsule to take by mouth. It is usually taken one or more times a day. The length of treatment depends ...
Browse our Drug Dictionary for generic drug names and brand names. ... Find information about Procarbazine including usage and side effects. ... How the drug is given. By mouth. Indications and Usage. Procarbazine is FDA approved with other anticancer drugs for the ... Patients Disease Information Treatment Types of Treatment Chemotherapy and Other Drug Therapies Drug Listings Procarbazine ...
Procarbazine Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists ( ... Interactions for Procarbazine Hydrochloride. Specific Drugs, Foods, and Therapies. Drug, Food, or Therapy ... Food and Drug Administration. Prescription drug advertising; content and format for labeling of human prescription drugs. Fed ... Procarbazine possesses some MAO inhibitory activity; avoid concomitant use with certain food or prescription and OTC drugs.100 ...
... from CanadaPharmacy.com the largest mail order pharmacy in Canada.Order Matulane drug from a Canadian Pharmacy Online. ... What is a Generic Drug?. A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, ... Procarbazine interferes with the growth of cancer cells and slows their growth and spread in the body. Procarbazine is used to ... Prescriptions Non-Prescriptions Pet Medications Drug Refills Discount Products Search By Condition Online Pharmacy Coupons ...
Procarbazine - A Traditional Drug in the Treatment of Malignant Gliomas. Author(s): Rainer Goerne, Ulrich Bogdahn, Peter Hau. ... Rainer Goerne, Ulrich Bogdahn and Peter Hau, " Procarbazine - A Traditional Drug in the Treatment of Malignant Gliomas", ... The drug is not cross-resistant with other mustard-type alkylating agents. As PCZ was in almost all trials used in a ... The drug is not cross-resistant with other mustard-type alkylating agents. As PCZ was in almost all trials used in a ...
Drug information provided by: Micromedex. In deciding to use a medicine, the risks of taking the medicine must be weighed ... Information about this procarbazine-oral-route. Pregnancy Category. Explanation. All Trimesters. D. Studies in pregnant women ... Epilepsy-Procarbazine may change the seizures * Headaches (severe or frequent)-You may not realize when a severe headache is ... Infection-Procarbazine can reduce immunity to infection * Kidney disease-Effects may be increased because of slower removal of ...
Procarbazine is an antineoplastic agent used in combination with other cancer drugs for the treatment of Stage III and IV ... Procarbazine is available through select specialty pharmacies. Your oncology team will work with your prescription drug plan to ... How to Take Procarbazine. Procarbazine comes as a capsule, to be taken by mouth. Take the capsule whole, do not break, chew, or ... About: Procarbazine (Matulane®) Procarbazine exerts its anti-cancer affect by a process called alkylation. Alkylation damages ...
Drug Administration. Procarbazine is taken orally as a pill.. Side Effects. Common side effects include low blood counts and ... Procarbazine is a chemotherapy drug that is administered for the treatment of brain cancer, multiple myeloma, melanoma, and ... This drug is used in the treatment of both Hodgkins and Non-Hodgkins Lymphomas, and is administered in conjunction with other ... Procarbazine is known to react with certain foods that have a high tyramine content. The following should be avoided to prevent ...
Procarbazine is given with other cancer medicines to treat Hodgkins Disease (a type of blood cancer). Procarbazine may also be ... Procarbazine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. ... What other drugs will affect procarbazine?. Taking procarbazine with other drugs that make you sleepy or slow your breathing ... The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug ...
Drug: cytarabine Drug: dexamethasone Drug: lomustine Drug: methotrexate Drug: procarbazine hydrochloride Phase 2 ... Drug Information available for: Methotrexate Cytarabine Procarbazine hydrochloride Procarbazine Lomustine Genetic and Rare ... RATIONALE: Drugs used in chemotherapy, such as methotrexate, procarbazine, lomustine, dexamethasone, and cytarabine, use ... Procarbazine. BB 1101. Anti-Inflammatory Agents. Antiemetics. Autonomic Agents. Peripheral Nervous System Agents. Physiological ...
The classic guide to all major prescription and nonprescription drugs, featuring revised, up-to date FDA information and an A-Z ... It includes coverage of dosage and length of time before the drug takes effect, side effects, special precautions, interactions ... comprehensive and affordable guide to prescription and nonprescription drugs. ... with other food and drugs, standards for use by different age groups, and much more. It also features a generic and brand name ...
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Com... ... Drug Discovery Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs ... drug may kill more tumor cells. It is not yet known whether giving procarbazine alone or with isotretinoin is more effective ... Procarbazine in Treating Patients With Recurrent Brain Tumor. RATIONALE: Drugs used in chemotherapy use different ways to stop ...
Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding information is provided. ... Consumer information about the drug atropine ophthalmic used to treat inflammatory conditions of the eye, and is used prior to ... procarbazine (Matulane), * rasagiline (Azilect), *selegiline (Eldepryl, Zelapar, Carbex), *tranylcypromine (Parnate) and others ... Report Problems to the Food and Drug Administration. You are encouraged to report negative side effects of prescription drugs ...
The mechanism of action of an anxiolytic drug depends upon the specific drug class to which it belongs. Side effects of anti- ... is a drug class that is comprised of other types of drug classes, for example, benzodiazepines, antidepressants, and ... procarbazine (Matulane). Patients that take such combinations may develop confusion, high blood pressure, tremor, hyperactivity ... Which drugs or supplements interact with anti-anxiety drugs?. *List of examples of brand and generic names available for anti- ...
Procarbazine • Safrazine • Tranylcypromine MAO-A selective: Amiflamine • Bazinaprine • Befloxatone • Befol • Brofaromine • ... This is a list of dopaminergic drugs. These are pharmaceutical drugs, naturally occurring compounds and other chemicals that ...
PCV stands for a drug cocktail, i.e. a mixture of three chemotherapeutic components: *drug 1: procarbazine ... drug 3: vincristine. Figure 2The prediction model consists of a coupled pharmacokinetic model (PK) and tumour growth model ...
Includes common brand names, drug descriptions, warnings, side effects and dosing information. ... Drugs.com Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ... Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and ... By clicking Subscribe, I agree to the Drugs.com Terms & Conditions and Privacy Policy and understand that I may opt out of ...
Drug-induced cutaneous disorders frequently display a characteristic clinical morphology such as morbilliform exanthem, ... 42] Fixed drug eruptions may account for as much as 16-21% of all cutaneous drug eruptions. The actual frequency may be higher ... Certain classes of drugs with cross-reactions within a class have been reported to elicit a fixed drug eruption with quinolones ... Fixed drug eruption due to nabumetone in a patient with previous fixed drug eruptions due to naproxen. J Investig Allergol Clin ...
Biological: filgrastim Drug: cyclophosphamide Drug: etoposide Drug: lomustine Drug: procarbazine hydrochloride Radiation: ... Drug: lomustine Patients receive oral lomustine on day 1.. Drug: procarbazine hydrochloride Oral and procarbazine on days 22-31 ... Procarbazine. Lenograstim. Immunosuppressive Agents. Immunologic Factors. Physiological Effects of Drugs. Antirheumatic Agents ... Drug: etoposide Oral etoposide on days 1-3. The course is repeated every 6 weeks. A complete or partial response after 1 course ...
Drug: Procarbazine 60 mg/m² p.o. for 10 days, max. 3 times 100 mg p.o. for 5 days, max. 6 times ... Procarbazine. Antineoplastic Agents, Immunological. Antineoplastic Agents. Immunologic Factors. Physiological Effects of Drugs ... and procarbazine] followed by maintenance therapy with procarbazine is effective in the treatment of cerebral Non Hodgkin ... Drug Information available for: Methotrexate Genetic and Rare Diseases Information Center resources: Lymphosarcoma Primary ...
The drug-loaded resin particle is a sustained-release coated layered pharmaceutical drug-ion exchange resin having a one or ... more pharmaceutically active drugs applied directly to a non-equilibrated ion exchange resin to form a drug-resin complex. The ... The present invention provides a method and composition are provided for loading one or more drugs in a solution onto one or ... drug-resin complex then coated is shelf stable. ... more ion exchange resin particles to form a drug-loaded resin ...
Drug: lomustine Drug: procarbazine hydrochloride Drug: vincristine sulfate Radiation: radiation therapy Phase 3 ... Drug Information available for: Procarbazine Genetic and Rare Diseases Information Center resources: Glioma Oligodendroglioma ... Patients receive oral lomustine on day 1, oral procarbazine on days 8-21, and vincristine IV on days 8 and 29. Treatment ... Procarbazine. Antineoplastic Agents, Phytogenic. Antineoplastic Agents. Tubulin Modulators. Antimitotic Agents. Mitosis ...
A) When drugs in the main list cannot be made available.. (B) When drugs in the main list are known to be ineffective or ... 1) Drugs subject to international control under: (a) the Single Convention on Narcotic Drugs (1961); (b) the Convention on ... Adequate resources and specialist oversight are a prerequisite for the introduction of this class of drugs. ... The drugs are included in the relevant sections of the model list according to their therapeutic use, e.g. analgesics. ...
Procarbazine, lomustine (CCNU), vincristine. Oral chemotherapy drugs administered in combination (PCV) on a specific ... Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly ... Procarbazine, CCNU, vincristine (PCV) chemotherapy for benign oligodendroglioma. Neurology. 1994. 44(Suppl 2):A262-A263. ... If the treatment should fail, radiation therapy, other clinical trials for recurrent gliomas, or other drugs may be considered ...
  • The methylhydrazine derivative Procarbazine (PCZ) as monotherapy or in combination with CCNU and vincristine (PCV) was evaluated in a vast number of clinical trials and is still used in patients with high-grade and low-grade gliomas. (eurekaselect.com)
  • Patients should avoid smoking while taking procarbazine because there is an increased risk of developing lung cancer. (oncolink.org)
  • Your healthcare team will consider your personal needs to plan the drugs, doses and schedules of chemotherapy. (cancer.ca)
  • The following doses are for administration of the drug as a single agent. (wikidoc.org)
  • Adults: To minimize the nausea and vomiting experienced by a high percentage of patients beginning procarbazine therapy, single or divided doses of 2 to 4 mg/kg/day for the first week are recommended. (wikidoc.org)
  • The healthcare team will consider the type of HL, stage, tumour size (bulkiness) and risk group, as well as your child's personal needs, to plan the drugs, doses and schedules of chemotherapy. (cancer.ca)
  • However it may occur with cumulative or high doses of the drug. (chemocare.com)
  • The treatment and the maintenance doses of Procarbazine should be determined only by a physician experienced in the use of potent antineoplastic drugs in children. (medicines.org.uk)
  • Further attempts to combine 8 g/m 2 doses of MTX with other drugs such as thiotepa have resulted in unacceptable toxicity. (medscape.com)
  • [ 2 ] Unlike doses of 8 g/m 2 , MTX given at 1 to 3.5 g/m 2 can be safely combined with other drugs. (medscape.com)
  • A dose reduction and/or omission of 5HT3 antagonist for subsequent doses of procarbazine may be considered depending on the patient's emetogenic response to the treatment. (eviq.org.au)
  • All listed drugs are considered hazardous, but safe-handling precautions can vary with the activity and the formulation of the drug. (cdc.gov)
  • The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. (cancer.gov)
  • While this drug may be prescribed for children as young as 6 years old for selected conditions, precautions do apply. (cvs.com)
  • Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. (aarp.org)
  • Selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) have many important drug interactions when they are used for the treatment of anxiety or other health conditions. (medicinenet.com)
  • If your doctor has directed you to use this medication , your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. (rxlist.com)
  • Dextromethorphan has serious interactions with at least 36 different drugs. (rxlist.com)
  • Dextromethorphan has moderate interactions with at least 38 different drugs. (rxlist.com)
  • This updated edition in the long standing series provides the latest information on many individual drugs, including the most complete coverage of their adverse reactions and interactions. (credoreference.com)
  • Find information on drug interactions, side effects, and more. (aarp.org)
  • Usually drug interactions occur when it is taken with another drug or with food. (internationaldrugmart.com)
  • Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Generic for Setrona*, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions. (internationaldrugmart.com)
  • Anyone starting this drug should review the other medications they are taking with their physician and pharmacist for possible interactions. (encyclopedia.com)
  • Anticipating and controlling drug-drug interactions (DDIs) in older patients with painful diabetic peripheral neuropaty (pDPN) presents a significant challenge to providers. (biomedcentral.com)
  • The purpose of this study was to examine the impact of newly initiated pregabalin or duloxetine treatment on Medicare Advantage Prescription Drug (MAPD) plan pDPN patients' encounters with potential drug-drug interactions, the healthcare cost and utilization consequences of those interactions, and opioid utilization. (biomedcentral.com)
  • Patients should not take anxiolytic drugs with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants or other drugs that inhibit MAOIs such as linezolid [Zyvox] and intravenous methylene blue . (medicinenet.com)
  • Interruption or discontinuance of the drug may be required in patients experiencing toxicity. (drugs.com)
  • Side effects may be more likely to occur in elderly patients, who are usually more sensitive to the effects of procarbazine. (mayoclinic.org)
  • Patients should avoid alcoholic beverages while taking procarbazine. (oncolink.org)
  • phase III trial to compare the effectiveness of procarbazine alone or with isotretinoin in treating patients with recurrent primary malignant gliomas. (bioportfolio.com)
  • OBJECTIVES: I. Determine whether the combination of isotretinoin and procarbazine can improve time to progression and survival compared to procarbazine alone in patients with recurrent malignant gliomas. (bioportfolio.com)
  • Patients are randomized to receive procarbazine alone or in combination with isotretinoin. (bioportfolio.com)
  • Arm I: Patients receive oral procarbazine once daily on days 1-14 every 28 days. (bioportfolio.com)
  • Arm II: Patients receive procarbazine by mouth once daily on days 1-14 followed by 2 weeks of rest. (bioportfolio.com)
  • There is limited information regarding Off-Label Guideline-Supported Use of procarbazine in adult patients. (wikidoc.org)
  • There is limited information regarding Off-Label Non-Guideline-Supported Use of procarbazine in adult patients. (wikidoc.org)
  • There is limited information regarding FDA-Labeled Use of procarbazine in pediatric patients. (wikidoc.org)
  • Triazolam should not be used in patients with preexisting respiratory depression, cases of shock, or coma because the drug can worsen respiratory and CNS depression. (pdr.net)
  • Treatment with triazolam should not be reinitiated in patients who experience angioedema after administration of the drug. (pdr.net)
  • Some drugs (eg, nitrofurantoin ) can cause different injury patterns in different patients. (merckmanuals.com)
  • A screening pulmonary function test is commonly done in patients about to begin or already taking drugs with pulmonary toxicities, but the benefits of screening for prediction or early detection of toxicity are unproved. (merckmanuals.com)
  • Caution is advisable in patients with hepatic or renal dysfunction and Procarbazine should be avoided in patients with severe hepatic or renal disease. (medicines.org.uk)
  • Patients who are allergic to citalopram, any other SSRI drug, or any component of the preparation should not take citalopram. (encyclopedia.com)
  • Patients with liver problems and elderly patients (over age 65) need to take smaller amounts of the drug. (encyclopedia.com)
  • If sexual side effects continue, the dose of citalopram may be reduced, patients can also have drug holidays where the weekend dose is either decreased or skipped, or they can discuss with their physician the risks and benefits of switching to another antidepressant. (encyclopedia.com)
  • Patients with delayed MTX elimination may be rescued with the use of glucarpidase, which is a recombinant carboxypeptidase G2 enzyme (Voraxaze, Protherics UK Ltd.). [ 8 , 11 ] This drug is commercially available in Europe under special regulation, and through an orphan drug program in the US. (medscape.com)
  • Early concerns about occupational exposure to provides some guidance on engineering controls antineoplastic drugs first appeared in the 1970s. (cdc.gov)
  • Multicenter study of environmental contamination with antineoplastic drugs in 36 Canadian hospitals: a 2013 follow-up study. (cdc.gov)
  • Cavallo D, Ursini CL, Perniconi B, Francesco AD, Giglio M, Rubino FM, Marinaccio A and Iavicoli S. Evaluation of gentotoxic effects induced by exposure to antineoplastic drugs in lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees. (cdc.gov)
  • It is recommended that procarbazine be given only by or under the supervision of a physician experienced in the use of potent antineoplastic drugs. (wikidoc.org)
  • All antineoplastic drugs and essential supportive drugs in this protocol are included on the World Health Organisation (WHO) Model List of Essential Medicines (20th List March 2017). (eviq.org.au)
  • The cost includes antineoplastic drugs only (not antiemetics or other supportive medications), unless otherwise indicated. (eviq.org.au)
  • The cost displayed is the actual drug cost and does not necessarily reflect the cost incurred by the patient as many antineoplastic drugs are reimbursed on the PBS. (eviq.org.au)
  • Side effects of chemotherapy will depend mainly on the type of drug, the dose, how it's given, where it's given and your overall health. (cancer.ca)
  • The major categories of causative agents of fixed drug eruption include antibiotics, antiepileptics, nonsteroidal anti-inflammatory agents, sildenafil, and phenothiazines, although numerous other agents and certain foods such as cashews and licorice have also been reported as causative agents. (medscape.com)
  • Generic for Setrona* can interact with other antidepressants, nonsteroidal anti-inflammatory drugs, and MAOIs. (internationaldrugmart.com)
  • Although NIOSH hazardous drug evaluation includes consideration of carcinogenicity and geno- toxicity, this evaluation is tailored to identify and evaluate data from human toxicity profiles, animal studies and in vitro studies unique to evaluating therapeutic agents. (cdc.gov)
  • Upon evidence of hematologic or other toxicity , the drug should be discontinued until there has been satisfactory recovery. (wikidoc.org)