Dry Powder Inhalers: A device that delivers medication to the lungs in the form of a dry powder.Powders: Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)Nebulizers and Vaporizers: Devices that cause a liquid or solid to be converted into an aerosol (spray) or a vapor. It is used in drug administration by inhalation, humidification of ambient air, and in certain analytical instruments.Metered Dose Inhalers: A small aerosol canister used to release a calibrated amount of medication for inhalation.Administration, Inhalation: The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.Aerosols: Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.Bronchodilator Agents: Agents that cause an increase in the expansion of a bronchus or bronchial tubes.Chlorofluorocarbons: A series of hydrocarbons containing both chlorine and fluorine. These have been used as refrigerants, blowing agents, cleaning fluids, solvents, and as fire extinguishing agents. They have been shown to cause stratospheric ozone depletion and have been banned for many uses.Budesonide: A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.Aerosol Propellants: Compressed gases or vapors in a container which, upon release of pressure and expansion through a valve, carry another substance from the container. They are used for cosmetics, household cleaners, and so on. Examples are BUTANES; CARBON DIOXIDE; FLUOROCARBONS; NITROGEN; and PROPANE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Pregnadienediols: Doubly unsaturated pregnane derivatives with two hydroxy groups substituted anywhere on the rings or side chains.Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.Beclomethasone: An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.Particle Size: Relating to the size of solids.Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Anti-Asthmatic Agents: Drugs that are used to treat asthma.Terbutaline: A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.Ethanolamines: AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.Hydrocarbons, FluorinatedTherapeutic Equivalency: The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.ChlorobenzenesDrug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Forced Expiratory Volume: Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.Pregnenediones: Unsaturated pregnane derivatives containing two keto groups on side chains or ring structures.Equipment Design: Methods of creating machines and devices.Inspiratory Capacity: The maximum volume of air that can be inspired after reaching the end of a normal, quiet expiration. It is the sum of the TIDAL VOLUME and the INSPIRATORY RESERVE VOLUME. Common abbreviation is IC.Lactose: A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.Excipients: Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.Drug Compounding: The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)Technology, Pharmaceutical: The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.Capsules: Hard or soft soluble containers used for the oral administration of medicine.Benzyl Alcohols: Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.Cross-Over Studies: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)Adrenergic beta-2 Receptor Agonists: Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS.Scopolamine Derivatives: Analogs or derivatives of scopolamine.Peak Expiratory Flow Rate: Measurement of the maximum rate of airflow attained during a FORCED VITAL CAPACITY determination. Common abbreviations are PEFR and PFR.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Androstadienes: Derivatives of the steroid androstane having two double bonds at any site in any of the rings.Drug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Inhalation: The act of BREATHING in.Adrenal Cortex HormonesInhalation Spacers: A variety of devices used in conjunction with METERED DOSE INHALERS. Their purpose is to hold the released medication for inhalation and make it easy for the patients to inhale the metered dose of medication into their lungs.Respiratory Therapy: Care of patients with deficiencies and abnormalities associated with the cardiopulmonary system. It includes the therapeutic use of medical gases and their administrative apparatus, environmental control systems, humidification, aerosols, ventilatory support, bronchopulmonary drainage and exercise, respiratory rehabilitation, assistance with cardiopulmonary resuscitation, and maintenance of natural, artificial, and mechanical airways.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Freeze Drying: Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Respiratory System Agents: Drugs used for their effects on the respiratory system.Desiccation: Removal of moisture from a substance (chemical, food, tissue, etc.).Powder Diffraction: Method of using a polycrystalline powder and Rietveld refinement (LEAST SQUARES ANALYSIS) of X-RAY DIFFRACTION or NEUTRON DIFFRACTION. It circumvents the difficulties of producing single large crystals.Ipratropium: A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Fenoterol: An adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.
  • For more information on COPD and COPD drugs and medications, please visit the subsequent websites: COPD International Mayo Clinc National Jewish Health National Heart Lung and Blood Institute Web - MD. I felt like needed a gallon of water before I could make another move. (bumbou.com)
  • Poor control may arise from inadequate adherence, incorrect inhaler technique or because the condition is refractory. (bmj.com)
  • Accordingly, novel inhalers continue to be developed to maximise use and minimise the possibility for incorrect inhaler technique. (biomedcentral.com)
  • This type of inhaler uses an ozone-depleting CFC propellant such as freon, which is banned for most commercial applications, but which presently has medical exemption. (justia.com)
  • Drug leakage was not significant when products were stored 4° and 25°/60% RH for three months, but particle size increased signifi cantly. (ijpsonline.com)
  • Physical state and dissolution of ibuprofen formulated by co-spray drying with mesoporous silica: effect of pore and particle size. (semanticscholar.org)
  • Publication date: 5 May 2018 Source:International Journal of Pharmaceutics, Volume 542, Issues 1-2 Author(s): Ka Yee Wan, Ka Wai Wong, Albert Hee Lum Chow, Shing Fung Chow Flash nanoprecipitation (FNP) is a controlled antisolvent precipitation process that has proven effective for consistent production of drug nanoparticles with a defined mean particle size and narrow particle size distribution. (medworm.com)
  • Thus, BE of these drug/device combination products is established based on an aggregate weight of evidence, which utilizes in vitro studies to demonstrate equivalence of in vitro performance, pharmacokinetic or pharmacodynamic studies to demonstrate equivalence of systemic exposure, and pharmacodynamic and clinical endpoint studies to demonstrate equivalence in local action. (pubmedcentralcanada.ca)
  • 1999 - 2002: Postdoctoral research fellow investigating In-vitro & In-vivo Aspects of Dry Powder Inhalers, at the School of Pharmacy, University of Bradford, UK. (brad.ac.uk)
  • Merxin and Amiko take connected inhalers one step further: we presented our connected inhalers work at DDL 2018, the work was very well received. (slideshare.net)
  • The conventional injection devices segment accounted for the largest share of the injectable drug delivery market in 2018. (researchandmarkets.com)
  • Publication date: 5 May 2018 Source:International Journal of Pharmaceutics, Volume 542, Issues 1-2 Author(s): T. Hatahet, M. Morille, A. Hommoss, J.M. Devoisselle, R.H. Müller, S. Bégu Quercetin is a flavonoid with strong antioxidant and antiinflammatory activities considered as a potential drug candidate for skin exogenous supplementation. (medworm.com)
  • Publication date: 5 May 2018 Source:International Journal of Pharmaceutics, Volume 542, Issues 1-2 Author(s): Dae Gon Lim, Racelly Ena Prim, Eunah Kang, Seong Hoon Jeong The self-organizing complexes with hyaluronic acid (HA) and polydopamine (PDA), an adhesion mediator via hydrogen bonding, were investigated for use as protein drug carriers. (medworm.com)
  • An apparatus for aerosolizing a dose of powdered medicine for inhalation, comprising in combination a solid core defining a diskshaped aerosolizing chamber, the chamber defined by spaced-apart, flat front and rear walls terminated by a circumferential wall, the core including a first end piece having. (google.ca)
  • Open the inhaler mouthpiece, or remove the cap. (drugs.com)
  • 5. The dry powder inhaler of claim 1 further comprising a mouthpiece on the second plate. (google.com)
  • 6. The dry powder inhaler of claim 5 further comprising a mouthpiece cover on the third plate. (google.com)
  • 7. The dry powder inhaler of claim 5 further including a mouthpiece cover on the third plate having a cap section adapted to fit over the mouthpiece. (google.com)
  • a mouthpiece cover pivotable relative to the shear plate for moving the blister post from a first position, where the blister container is sealed, and the inhaler is in the closed position, to a second position wherein the first portion of the second layer is sheared away from the blister container, to unseal the blister container, as the inhaler is moved into the open position. (google.com)
  • 10. The inhaler of claim 9 with the mouthpiece cover having a cap section adapted to fit over the mouthpiece, a base plate, and a shield plate including a blister shield dome covering the first layer of the blister container. (google.com)
  • 3. The inhaler of claim 1 , wherein the flexible, elastic material of the distal end of the mouthpiece comprises at least one flexible tab, wherein the at least one flexible tab covers the at least one exhaust port during inhalation and deflects during exhalation by the patient, whereby exhaust air escapes from between the flexible, elastic material of the mouthpiece and the chamber body. (google.com)
  • The powder evacuates the capsule through the two holes created by the piercing system and is inhaled by the patient through the mouthpiece. (webpackaging.com)
  • In the USA, MDIs are labeled according to the amount of drug delivered at the mouthpiece, whereas in Canada and the EU they are labeled according to the amount of drug delivered from the valve. (merckvetmanual.com)
  • For the majority of orally administered drugs that reach their site(s) of action through the systemic circulation, BE is demonstrated based on drug concentration in a relevant biologic fluid (e.g., plasma or blood). (pubmedcentralcanada.ca)
  • Their drug delivery and intended action do not rely on the systemic circulation. (pubmedcentralcanada.ca)
  • They offer the benefit of avoiding systemic exposure to drugs, while ensuring that the drugs go directly to where they are needed (i.e. the lungs). (news-medical.net)
  • A drug delivery composition comprising a plurality of microspheres and active drug associated with each microsphere, the drug being for systemic delivery and having a maximum molecular weight of 6000, and the composition being substantially free of an enhancer. (google.es)
  • 1. A drug delivery composition which is suitable for transmucosal delivery and which comprises a plurality of microspheres adapted to gel in contact with the mucosal surface and active drug associated with each microsphere, the composition being substantially free of an enhancer, characterised in that the drug is for systemic delivery and is a peptide having a maximum molecular weight of 6000, and the microspheres comprise starch, gelatin, collagen or dextran. (google.es)
  • Besides delivery of the drug at the site of action, this form of therapy minimises systemic side effects and bypasses the first-pass metabolism of drugs in the gastrointestinal tract and liver. (indmedica.com)
  • The inherent characteristics, size, and nature of the drug delivery technology make the DoseOne™ inhaler hugely advantageous for numerous end use applications. (fiercepharma.com)
  • Regarding the safety characteristics of mometasone furoate dry powder inhaler, the authors claim that both drugs provide a comparable degree of safety based on the lack of effect on the hypothalamic-pituitary-adrenal axis. (ersjournals.com)
  • Because of the simplicity of the Analgizer and the pharmacological characteristics of methoxyflurane, it was easy for patients to self-administer the drug and rapidly achieve a level of conscious analgesia which could be maintained and adjusted as necessary over a period of time lasting from a few minutes to several hours. (wikipedia.org)
  • HOS guides protein function, so is studied and monitored throughout the drug development process to understand and manage a drug s characteristics and deliver a safe, effective product. (manufacturingchemist.com)
  • Computational fluid dynamics analysis showed that at the critical flow rate of 65 l min −1 , the volume-averaged integral scale strain rate (ISSR) was 5,400 s −1 , and the average particle impaction velocities were 12.7 and 19.0 m s −1 at the inhaler base and grid, respectively. (springer.com)
  • 2019 , " the global pulmonary drug delivery systems market was valued at USD 21.03billion in 2012 and is expected to grow at a CAGR of4.5% from 2013 to 2019, to reach an estimated value of USD 28.70billion in 2019. (pitchengine.com)
  • The global market for pulmonary drug delivery systems is dominated by companies such as GlaxoSmithKline, plc, Boehringer Ingelheim, AstraZeneca, Merck & Co., Philips Respironics and Omron Healthcare. (pitchengine.com)
  • These players collectively accounted for more than 75% of the global pulmonary drug delivery systems market revenue in 2012.Some other players operating in this market include Novartis AG, CareFusion Corporation, 3M Health Care, PARI Respiratory Equipment, Inc., Sunovion Pharmaceuticals Inc., Allied Healthcare Products, Inc., and GF Health Products Inc. (pitchengine.com)
  • Reports on developments in pulmonary drug delivery that help overcome obstacles associated with injection for respiratory diseases. (ebscohost.com)
  • Global pulmonary drug delivery system market is estimated to reach $54.9 Billion by 2025 with CAGR of 6.2% between 2017 and 2025. (giiresearch.com)
  • Increasing prevalence of chronic respiratory diseases like asthma, bronchitis is expected to grow the market of Pulmonary Drug Delivery Systems. (giiresearch.com)
  • However, regulatory approvals and patent expiration of drugs may hamper the growth of global pulmonary drug delivery market. (giiresearch.com)
  • The global pulmonary drug delivery systems market is segmented on the basis of product, application, and geography. (giiresearch.com)
  • By geography, the global pulmonary drug delivery system market is segmented into North America, Europe, Asia-Pacific, and Rest of the world (RoW). (giiresearch.com)
  • Advances in Pulmonary Drug Delivery , edited by Philip Chi Lip Kwok and Hak-Kim Chan , CRC Press, Boca Raton, 2017. (edu.au)