Anti-Infective Agents, Urinary
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
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Dibenzoxazepines | Profiles RNS
MUSM RE Pharm Flashcards | Quizlet
Urinary antiseptic; MOA: unchanged drug (~40%) is excreted into urine; bacteria in urinary tract reduce drug to reactive ... Nalidixic acid; Cinoxacin. Quinolones ; MOA: inhibits DNA gyrase and topoisomerase IV ; Given orally ; MOR: DNA gyrase mutation ... due to accumulation of and retention of drug in PCT cells)=, may prevent drug excretion and increase ototoxicity; teratogenic. ... Drug interactions: prevents renal secretion of penicillin and other drugs/organic acids ...