Drug Therapy: The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Pharmacogenetics: A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).Pharmacists: Those persons legally qualified by education and training to engage in the practice of pharmacy.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Drug Utilization Review: Formal programs for assessing drug prescription against some standard. Drug utilization review may consider clinical appropriateness, cost effectiveness, and, in some cases, outcomes. Review is usually retrospective, but some analysis may be done before drugs are dispensed (as in computer systems which advise physicians when prescriptions are entered). Drug utilization review is mandated for Medicaid programs beginning in 1993.Anticonvulsants: Drugs used to prevent SEIZURES or reduce their severity.Pharmaceutical Services: Total pharmaceutical services provided by qualified PHARMACISTS. In addition to the preparation and distribution of medical products, they may include consultative services provided to agencies and institutions which do not have a qualified pharmacist.Hypolipidemic Agents: Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Drug Prescriptions: Directions written for the obtaining and use of DRUGS.Community Pharmacy Services: Total pharmaceutical services provided to the public through community pharmacies.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Drug Costs: The amount that a health care institution or organization pays for its drugs. It is one component of the final price that is charged to the consumer (FEES, PHARMACEUTICAL or PRESCRIPTION FEES).Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Primidone: An antiepileptic agent related to the barbiturates; it is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with PHENOBARBITAL. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)Insurance, Pharmaceutical Services: Insurance providing for payment of services rendered by the pharmacist. Services include the preparation and distribution of medical products.Managed Care Programs: Health insurance plans intended to reduce unnecessary health care costs through a variety of mechanisms, including: economic incentives for physicians and patients to select less costly forms of care; programs for reviewing the medical necessity of specific services; increased beneficiary cost sharing; controls on inpatient admissions and lengths of stay; the establishment of cost-sharing incentives for outpatient surgery; selective contracting with health care providers; and the intensive management of high-cost health care cases. The programs may be provided in a variety of settings, such as HEALTH MAINTENANCE ORGANIZATIONS and PREFERRED PROVIDER ORGANIZATIONS.Antithyroid Agents: Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.Patient Compliance: Voluntary cooperation of the patient in following a prescribed regimen.Adrenergic beta-Antagonists: Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.Education, Pharmacy, Continuing: Educational programs designed to inform graduate pharmacists of recent advances in their particular field.Drug Monitoring: The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically.Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.Leprostatic Agents: Substances that suppress Mycobacterium leprae, ameliorate the clinical manifestations of leprosy, and/or reduce the incidence and severity of leprous reactions.Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.Practice Guidelines as Topic: Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.Phenylpropanolamine: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Medication Therapy Management: Assistance in managing and monitoring drug therapy for patients receiving treatment for cancer or chronic conditions such as asthma and diabetes, consulting with patients and their families on the proper use of medication; conducting wellness and disease prevention programs to improve public health; overseeing medication use in a variety of settings.Organogold Compounds: Organic compounds that contain GOLD as an integral part of the molecule. Some are used as ANTIRHEUMATIC AGENTS. The term chrysotherapy derives from an ancient Greek term for gold.Graves Disease: A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).Recurrence: The return of a sign, symptom, or disease after a remission.Societies, Pharmaceutical: Societies whose membership is limited to pharmacists.Angiotensin-Converting Enzyme Inhibitors: A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.Catheter Ablation: Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Methimazole: A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.Anticholesteremic Agents: Substances used to lower plasma CHOLESTEROL levels.Economics, Pharmaceutical: Economic aspects of the fields of pharmacy and pharmacology as they apply to the development and study of medical economics in rational drug therapy and the impact of pharmaceuticals on the cost of medical care. Pharmaceutical economics also includes the economic considerations of the pharmaceutical care delivery system and in drug prescribing, particularly of cost-benefit values. (From J Res Pharm Econ 1989;1(1); PharmacoEcon 1992;1(1))Diuretics: Agents that promote the excretion of urine through their effects on kidney function.Pharmacokinetics: Dynamic and kinetic mechanisms of exogenous chemical and DRUG LIBERATION; ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and DRUG TOXICITY as a function of dosage, and rate of METABOLISM. LADMER, ADME and ADMET are abbreviations for liberation, absorption, distribution, metabolism, elimination, and toxicology.Polypharmacy: The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Pharmacy Service, Hospital: Hospital department responsible for the receiving, storing, and distribution of pharmaceutical supplies.Individualized Medicine: Therapeutic approach tailoring therapy for genetically defined subgroups of patients.Epilepsy, Reflex: A subtype of epilepsy characterized by seizures that are consistently provoked by a certain specific stimulus. Auditory, visual, and somatosensory stimuli as well as the acts of writing, reading, eating, and decision making are examples of events or activities that may induce seizure activity in affected individuals. (From Neurol Clin 1994 Feb;12(1):57-8)Bisoprolol: A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS.Medication Adherence: Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.Hydroxymethylglutaryl-CoA Reductase Inhibitors: Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.Patient Education as Topic: The teaching or training of patients concerning their own health needs.CresolsProspective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Cost-Benefit Analysis: A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Drug Utilization: The utilization of drugs as reported in individual hospital studies, FDA studies, marketing, or consumption, etc. This includes drug stockpiling, and patient drug profiles.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.United StatesPropafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.Antitubercular Agents: Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Carbimazole: An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Carbamazepine: An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Encainide: One of the ANTI-ARRHYTHMIA AGENTS, it blocks VOLTAGE-GATED SODIUM CHANNELS and slows conduction within the His-Purkinje system and MYOCARDIUM.Insurance Claim Review: Review of claims by insurance companies to determine liability and amount of payment for various services. The review may also include determination of eligibility of the claimant or beneficiary or of the provider of the benefit; determination that the benefit is covered or not payable under another policy; or determination that the service was necessary and of reasonable cost and quality.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.Lipotropic Agents: Endogenous factors or drugs that increase the transport and metabolism of LIPIDS including the synthesis of LIPOPROTEINS by the LIVER and their uptake by extrahepatic tissues.Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.Professional Role: The expected function of a member of a particular profession.Cost Sharing: Provisions of an insurance policy that require the insured to pay some portion of covered expenses. Several forms of sharing are in use, e.g., deductibles, coinsurance, and copayments. Cost sharing does not refer to or include amounts paid in premiums for the coverage. (From Dictionary of Health Services Management, 2d ed)Formularies as Topic: Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.Electrocardiography, Ambulatory: Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.Betahistine: A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.Calcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.Antirheumatic Agents: Drugs that are used to treat RHEUMATOID ARTHRITIS.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Physician's Practice Patterns: Patterns of practice related to diagnosis and treatment as especially influenced by cost of the service requested and provided.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Pregnatrienes: Pregnane derivatives containing three double bonds in the ring structures.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Guideline Adherence: Conformity in fulfilling or following official, recognized, or institutional requirements, guidelines, recommendations, protocols, pathways, or other standards.Medication Errors: Errors in prescribing, dispensing, or administering medication with the result that the patient fails to receive the correct drug or the indicated proper drug dosage.ThiazinesCardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Tranquilizing Agents: A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.Hyperlipidemias: Conditions with excess LIPIDS in the blood.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Cardiac Pacing, Artificial: Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.Clinical Pharmacy Information Systems: Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of clinical pharmacy services.Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.Cholesterol, LDL: Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Adrenal Cortex HormonesAntineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Sodium Chloride Symporter Inhibitors: Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Anti-HIV Agents: Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.Immunoglobulins, Thyroid-Stimulating: Autoantibodies that bind to the thyroid-stimulating hormone (TSH) receptor (RECEPTORS, THYROTROPIN) on thyroid epithelial cells. The autoantibodies mimic TSH causing an unregulated production of thyroid hormones characteristic of GRAVES DISEASE.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Procainamide: A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.Pain, Intractable: Persistent pain that is refractory to some or all forms of treatment.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.6-Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.Electric Countershock: An electrical current applied to the HEART to terminate a disturbance of its rhythm, ARRHYTHMIAS, CARDIAC. (Stedman, 25th ed)Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.Pharmacology: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.Health Care Costs: The actual costs of providing services related to the delivery of health care, including the costs of procedures, therapies, and medications. It is differentiated from HEALTH EXPENDITURES, which refers to the amount of money paid for the services, and from fees, which refers to the amount charged, regardless of cost.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Disease Management: A broad approach to appropriate coordination of the entire disease treatment process that often involves shifting away from more expensive inpatient and acute care to areas such as preventive medicine, patient counseling and education, and outpatient care. This concept includes implications of appropriate versus inappropriate therapy on the overall cost and clinical outcome of a particular disease. (From Hosp Pharm 1995 Jul;30(7):596)Hyperthyroidism: Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.Hypoglycemic Agents: Substances which lower blood glucose levels.Tachycardia, Supraventricular: A generic expression for any tachycardia that originates above the BUNDLE OF HIS.Defibrillators, Implantable: Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.Gastrointestinal Diseases: Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Metabolic Detoxication, Drug: Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Valproic Acid: A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Cost Savings: Reductions in all or any portion of the costs of providing goods or services. Savings may be incurred by the provider or the consumer.Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.PropylaminesEducation, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.Forecasting: The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.Barbiturates: A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Tachycardia, Ectopic Atrial: Abnormally rapid heartbeats originating from one or more automatic foci (nonsinus pacemakers) in the HEART ATRIUM but away from the SINOATRIAL NODE. Unlike the reentry mechanism, automatic tachycardia speeds up and slows down gradually. The episode is characterized by a HEART RATE between 135 to less than 200 beats per minute and lasting 30 seconds or longer.Pulmonary Veins: The veins that return the oxygenated blood from the lungs to the left atrium of the heart.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Monitoring, Physiologic: The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.Atrioventricular Node: A small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus. It gives rise to the atrioventricular bundle of the conduction system of the heart.Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.Drug Evaluation, Preclinical: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.Antidepressive Agents: Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.Albendazole: A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Societies, Medical: Societies whose membership is limited to physicians.Antiprotozoal Agents: Substances that are destructive to protozoans.Patient Selection: Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.Evidence-Based Medicine: An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.Atenolol: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.PiperazinesHydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Blood Pressure Determination: Techniques for measuring blood pressure.Health Maintenance Organizations: Organized systems for providing comprehensive prepaid health care that have five basic attributes: (1) provide care in a defined geographic area; (2) provide or ensure delivery of an agreed-upon set of basic and supplemental health maintenance and treatment services; (3) provide care to a voluntarily enrolled group of persons; (4) require their enrollees to use the services of designated providers; and (5) receive reimbursement through a predetermined, fixed, periodic prepayment made by the enrollee without regard to the degree of services provided. (From Facts on File Dictionary of Health Care Management, 1988)Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Pacemaker, Artificial: A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).Cytochrome P-450 CYP2D6: A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.Antidepressive Agents, Tricyclic: Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.Propylthiouracil: A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.Analgesics: Compounds capable of relieving pain without the loss of CONSCIOUSNESS.Anticoagulants: Agents that prevent clotting.Anthelmintics: Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.Guidelines as Topic: A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."Outcome Assessment (Health Care): Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
Prednisone in MOPP chemotherapy for Hodgkin's disease. (1/16029)High remission rates have been produced by MOPP (mustine, vincristine, procarbazine, and prednisone) chemotherapy in patients with advanced Hodgkin's disease, but the prednisone component has caused adverse effects in patients who have undergone radiotherapy. The remission rates and length of remission were reviewed in 211 patients with Hodgkin's disease who received chemotherapy either with or without prednisone. In contrast to the findings of a British study, there were no significant differences in remission rates or length of remission between patients who had received prednisone and patients who had not. There were differences between the British prospective study and this retrospective one, but it is difficult to know what accounted for the substantial differences in the findings. (+info)
Double-blind intervention trial on modulation of ozone effects on pulmonary function by antioxidant supplements. (2/16029)The aim of this study was to investigate whether the acute effects of ozone on lung function could be modulated by antioxidant vitamin supplementation in a placebo-controlled study. Lung function was measured in Dutch bicyclists (n = 38) before and after each training session on a number of occasions (n = 380) during the summer of 1996. The vitamin group (n = 20) received 100 mg of vitamin E and 500 mg of vitamin C daily for 15 weeks. The average ozone concentration during exercise was 77 microg/m3 (range, 14-186 microg/m3). After exclusion of subjects with insufficient compliance from the analysis, a difference in ozone exposure of 100 microg/m3 decreased forced expiratory volume in 1 second (FEV1) 95 ml (95% confidence interval (CI) -265 to -53) in the placebo group and 1 ml (95% CI -94 to 132) in the vitamin group; for forced vital capacity, the change was -125 ml (95% CI -384 to -36) in the placebo group and -42 ml (95% CI -130 to 35) in the vitamin group. The differences in ozone effect on lung function between the groups were statistically significant. The results suggest that supplementation with the antioxidant vitamins C and E confers partial protection against the acute effects of ozone on FEV1 and forced vital capacity in cyclists. (+info)
Epidemiology of drug-resistant tuberculosis in Texas. (3/16029)During 1987-1996, over 22,000 tuberculosis cases were reported in Texas, at an average annual incidence rate of 12.5 cases per 100,000 population. Counties with the highest rates were located along the Mexico-Texas border and in northwestern Texas. Nine percent of cases were resistant to at least one of the five first-line antituberculosis drugs used for treatment. Almost 5 percent (4.6%) were resistant to isoniazid, either alone or in combination with other antibiotics; 2.3% were resistant to rifampin; and only 1.3% were resistant to both isoniazid and rifampin. Being a recurrent case, being foreign-born, being 20-39 years of age, and residing in a Mexico-Texas border county were independent risk factors for isoniazid resistance and rifampin resistance. Tuberculosis patients with human immunodeficiency virus (HIV) infection were more likely to have rifampin resistance and less likely to have isoniazid resistance than patients without HIV infection. Factors associated with multi-drug-resistant tuberculosis included a history of previous tuberculosis (relative risk (RR) = 4.91, 95% confidence interval (CI) 3.5-6.8), non-US birth (RR = 2.69, 95% CI 2.1-3.5), age younger than 20 years (RR = 1.97, 95% CI 1.1-3.5), age 20-39 years (RR = 1.82, 95% CI 1.3-2.6), and residence in a Mexico-Texas border county (RR = 2.33, 95% CI 1.8-3.1). (+info)
In vivo isolated kidney perfusion with tumour necrosis factor alpha (TNF-alpha) in tumour-bearing rats. (4/16029)Isolated perfusion of the extremities with high-dose tumour necrosis factor alpha (TNF-alpha) plus melphalan leads to dramatic tumour response in patients with irresectable soft tissue sarcoma or multiple melanoma in transit metastases. We developed in vivo isolated organ perfusion models to determine whether similar tumour responses in solid organ tumours can be obtained with this regimen. Here, we describe the technique of isolated kidney perfusion. We studied the feasibility of a perfusion with TNF-alpha and assessed its anti-tumour effects in tumour models differing in tumour vasculature. The maximal tolerated dose (MTD) proved to be only 1 microg TNF-alpha. Higher doses appeared to induce renal failure and a secondary cytokine release with fatal respiratory and septic shock-like symptoms. In vitro, the combination of TNF-alpha and melphalan did not result in a synergistic growth-inhibiting effect on CC 531 colon adenocarcinoma cells, whereas an additive effect was observed on osteosarcoma ROS-1 cells. In vivo isolated kidney perfusion, with TNF-alpha alone or in combination with melphalan, did not result in a significant anti-tumour response in either tumour model in a subrenal capsule assay. We conclude that, because of the susceptibility of the kidney to perfusion with TNF-alpha, the minimal threshold concentration of TNF-alpha to exert its anti-tumour effects was not reached. The applicability of TNF-alpha in isolated kidney perfusion for human tumours seems, therefore, questionable. (+info)
Clinical experience and choice of drug therapy for human immunodeficiency virus disease. (5/16029)To determine if providers experienced in the management of human immunodeficiency virus (HIV) disease preferred different treatment regimens than providers with less experience, we analyzed data from a national survey of primary care providers' preferred regimens for the management of 30 HIV-related medical conditions. We mailed questionnaires to 999 correct addresses of providers in > 20 cities in the United States in May 1996. We received 524 responses (response rate, 52%). We found a statistically significant association between the number of HIV-infected patients cared for by the provider and the likelihood that the provider would report prescribing highly active antiretroviral therapy and multidrug combinations for treatment of opportunistic infections. Providers with few HIV-infected patients were substantially less likely to report using new therapeutic regimens or new diagnostic tools. We concluded that the preferred regimens of experienced providers are more likely to be consistent with the latest information on treatment for HIV disease than are those of less experienced providers. (+info)
Early mycological treatment failure in AIDS-associated cryptococcal meningitis. (6/16029)Cryptococcal meningitis causes significant morbidity and mortality in persons with AIDS. Of 236 AIDS patients treated with amphotericin B plus flucytosine, 29 (12%) died within 2 weeks and 62 (26%) died before 10 weeks. Just 129 (55%) of 236 patients were alive with negative cerebrospinal fluid (CSF) cultures at 10 weeks. Multivariate analyses identified that titer of cryptococcal antigen in CSF, serum albumin level, and CD4 cell count, together with dose of amphotericin B, had the strongest joint association with failure to achieve negative CSF cultures by day 14. Among patients with similar CSF cryptococcal antigen titers, CD4 cell counts, and serum albumin levels, the odds of failure at week 10 for those without negative CSF cultures by day 14 was five times that for those with negative CSF cultures by day 14 (odds ratio, 5.0; 95% confidence interval, 2.2-10.9). Prognosis is dismal for patients with AIDS-related cryptococcal meningitis. Multivariate analyses identified three components that, along with initial treatment, have the strongest joint association with early outcome. Clearly, more effective initial therapy and patient management strategies that address immune function and nutritional status are needed to improve outcomes of this disease. (+info)
Successful short-term suppression of clarithromycin-resistant Mycobacterium avium complex bacteremia in AIDS. California Collaborative Treatment Group. (7/16029)During a randomized study of clarithromycin plus clofazimine with or without ethambutol in patients with AIDS and Mycobacterium avium complex (MAC) bacteremia, eight participants received additional antimycobacterial drugs following the detection of a clarithromycin-resistant isolate (MIC, > 8 micrograms/mL). A macrolide (seven received clarithromycin, one azithromycin) and clofazimine were continued; additional treatment included various combinations of ethambutol, ciprofloxacin, amikacin, and rifabutin. After the detection of a resistant isolate and before receipt of additional antimycobacterials, the median peak MAC colony count in blood was 105 cfu/mL (range, 8-81,500 cfu/mL). After additional antimycobacterials, the median nadir MAC colony count was 5 cfu/mL (range, 0-110 cfu/mL). Five (63%) of eight patients had a > or = 1 log10 decrease, including two who achieved negative blood cultures; all of these responses occurred in patients originally assigned to clarithromycin plus clofazimine. Treatment of clarithromycin-resistant MAC bacteremia that emerges during clarithromycin-based treatment can decrease levels of bacteremia and transiently sterilize blood cultures. (+info)
A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/mycophenolate mofetil in renal transplant recipients. (8/16029)BACKGROUND: Between September 20, 1995 and September 20, 1997, 208 adult patients undergoing renal transplantation were randomized to receive tacrolimus/prednisone (n=106) or tacrolimus/prednisone/mycophenolate mofetil (n=102), with the goal of reducing the incidence of rejection. METHODS: The mean recipient age was 50.7+/-13.7 years. Sixty-three (30.3%) patients were 60 years of age or older at the time of transplantation. The mean donor age was 34.5+/-21.7 years. The mean cold ischemia time was 30.5+/-9.2 hr. The mean follow-up is 15+/-7 months. RESULTS: The overall 1-year actuarial patient survival was 94%; the overall 1-year actuarial graft survival was 87%. When the patient and graft survival data were stratified to recipients under the age of 60 who did not have delayed graft function, the overall 1-year actuarial patient survival was 97%, and the corresponding 1-year actuarial graft survival was 93%. There were no differences between the two groups. The overall incidence of rejection was 36%; in the double-therapy group, it was 44%, whereas in the triple therapy group, it was 27% (P=0.014). The mean serum creatinine was 1.6+/-0.8 mg/dl. A total of 36% of the successfully transplanted patients were taken off prednisone; 32% of the patients were taken off antihypertensive medications. The incidence of delayed graft function was 21%, the incidence of cytomegalovirus was 12.5%, and the initial and final incidences of posttransplant insulin-dependent diabetes mellitus were 7.0% and 2.9%; again, there was no difference between the two groups. CONCLUSIONS: This trial suggests that the combination of tacrolimus, steroids, and mycophenolate mofetil is associated with excellent patient and graft survival and a lower incidence of rejection than the combination of tacrolimus and steroids. (+info)
Study shows long-term benefits of initial combination therapy in RA
At the end of the year, every group demonstrated measurable improvements, with 32 percent of all the patients achieving clinical remission of their disease. However, patients who had received initial combination therapy--either with prednisone (group 3) or with infliximab (group 4)--had significantly less progression of radiographic joint damage than did patients treated with DMARDs only (group 1), or patients assigned to step-up combination therapy (group 2). The number of patients without any progression of radiographic joint damage was also higher in groups 3 and 4 than in groups 1 and 2. Furthermore, RA patients in both initial combination therapy groups experienced earlier functional improvement than did patients in either the DMARD monotherapy or step-up combination therapy group, according to scores of the Dutch version of the Health Assessment Questionnaire. Overall, patients who received initial combination therapy experienced no more side effects than patients in the other two groups ...
Initial combination therapy with ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial...
The AMBITION trial included a sizable number of patients with CTD-PAH, and within this SSc-PAH, and thus provides an opportunity to explore whether this population responds to initial combination therapy with ambrisentan and tadalafil compared with monotherapy of either agent. Initial combination therapy resulted in a reduction in the risk of clinical failure versus pooled monotherapy of 57% in patients with CTD-PAH and 56% in the subset of patients with SSc-PAH. While inferential statistics are not presented, the 95% CIs around the HR for both CTD-PAH and SSc-PAH were well within the bounds of 0-1. This result is further supported by the secondary endpoints, where we see a greater improvement in plasma NT-proBNP levels and 6MWD on combination therapy compared with monotherapy. The benefit of combination therapy over monotherapy is of similar magnitude to that observed in the whole trial population.. No new safety signals were identified in the CTD-PAH subset. However, some AEs appeared to be ...
Effect of Angiotensin-Converting Enzyme Inhibitor/Calcium Antagonist Combination Therapy on Renal Function in Hypertensive...
Effect of Angiotensin-Converting Enzyme Inhibitor/Calcium Antagonist Combination Therapy on Renal Function in Hypertensive...
Study Shows Combination Drug Therapy for Asthma Patients Is Safe
Combination Drugs Diagnostic Market Size | Industry Report, 2022
Global combination drugs diagnostic market is expected to witness exponential growth over the coming seven years due to greater efficiency attached to combination diagnosis and accelerated approval of drugs by the regulating authority. In addition, rising geriatric population base, improved diagnostic procedures and growing investments in R&D operations is further expected to drive the growth for combination drugs diagnostic market in near future
Table 6. What to Start: Initial Combination Regimens for Antiretroviral-Naive Pregnant Women | Recommendations for Use of...
Table 6. What to Start: Initial Combination Regimens for Antiretroviral-Naive Pregnant Women. These recommendations are for pregnant women who have never received antiretroviral therapy (ART) previously (i.e., antiretroviral-naive) and who have no evidence of significant resistance to regimen components. See Table 9 for more information on specific drugs and dosing in pregnancy.. Within each drug class and recommendation category, regimens are listed alphabetically, and the order does not indicate a ranking of preference. In addition, The Panel on Treatment of Pregnant Women with HIV Infection and Prevention of Perinatal Transmission (the Panel) makes no recommendation of one agent or regimen over another within each category (Preferred or Alternative).. It is recommended that women who become pregnant while on a stable ART regimen with viral suppression remain on that same regimen, with the exception of regimens containing didanosine, stavudine, or treatment-dose ritonavir, and (until more data ...
RESULTS: At baseline, there were no differences in demographics, WHO classification, hemodynamics, classification of PAH, or 6MWD among the 3 groups. The 6MWD significantly improved in the combination therapy group compared with the bosentan monotherapy and iloprost monotherapy groups at week 6 (P = .001) and after 3 months (P , .001), respectively. Secondary end points significantly improved in the combination therapy group for mean pulmonary artery pressure, cardiac index, and WHO functional classification after 3 months of treatment and for N-terminal pro-brain natriuretic peptide, Minnesota Living with Heart Failure questionnaire scores, and PaO2 after 6 weeks and 3 months of treatment, compared with the monotherapy groups. ...
Russian Heart Failure Journal 2005year Effects of combination therapies on clinical presentation, hemodynamics and morpho...
Urgency. Despite the great variety of drugs for treatment of CHF rational pharmacotherapy is not always applied in a proper way, especially in using combination therapies. Aim. Evaluating the effects of current combined pathogenetic therapies on clinical manifestations of disease, hemodynamics, morpho-functional parameters of the heart and exercise tolerance in patients with II-IV NYHA FC CHF having complicated the course of IHD. Material and methods. Study was performed on 355 patients aged from 43 to 76 years with II-IV NYHA FC CHF and left ventricular ejection fraction (LV EF) ,45% having complicated the course of IHD. Evaluation of combination therapy efficacy and safety included dynamics of clinical manifestations of disease, hemodynamic parameters, cardiac bioelectric activity and rhythmic performance; dynamics of morpho-functional cardiac parameters; analysis of laboratory data. Results. Pharmacotherapy of II-IV FC CHF having complicated the course of IHD should be a combination ...
ONGLYZA™ (saxagliptin) With Metformin as Initial Combination Therapy Provided 76-Week Long-Term Glycemic Control in...
Impact of peginterferon alpha‐2b and entecavir hydrate combination therapy on persistent viral suppression in patients with...
Effects of 2 Initial Standard Antiretroviral Combinations Therapies on Lipid Metabolism - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Effects of 2 Initial Standard Antiretroviral Combinations Therapies on Lipid Metabolism - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
This is the first randomized controlled trial to evaluate the efficacy and safety of the initial combination of an SGLT2 inhibitor and a DPP-4 inhibitor in subjects with type 2 diabetes. Initial combination of empagliflozin/linagliptin led to clinically meaningful reductions from baseline in HbA1c in subjects with type 2 diabetes, with ,50% of subjects reaching HbA1c ,7% (,53 mmol/mol) at week 52. Greater reductions from baseline in HbA1c (of up to 1.93% [21.1 mmol/mol]) were observed with empagliflozin/linagliptin in subjects with baseline HbA1c ≥8.5% (≥69 mmol/mol) compared with those with baseline HbA1c ,8.5% (,69 mmol/mol) who had reductions of up to 0.96% (10.5 mmol/mol). Initial combination of empagliflozin/linagliptin may be an option in patients presenting with marked hyperglycemia, as achieving glycemic targets may be challenging with traditional stepwise treatment escalation, and treatment escalation in clinical practice is often delayed. In a retrospective analysis of ,3,000 ...
Improved long-term survival in patients on combination therapies following an incident acute myocardial infarction: a...
Results In total, 975 deaths occurred during 1 year follow-up, culminating to 3247 by 11 years. 1-year risk of death was significantly reduced for all drug combinations, but not for drugs dispensed in isolation. Out to 11 years, only combinations of β-blockers and statins (with or without ACE inhibitors/angiotensin II receptor blockers (ACEi/ARB)) provided significant reductions in risk of all-cause mortality. In men, the greatest reduction in risk was associated with being dispensed β-blockers and statins (HR 0.46, 95% CI 0.36 to 0.58), whereas women benefited most from being dispensed β-blockers, statins and ACEi/ARBs (HR 0.77, 95% CI 0.60 to 0.99).. ...
Pharmaceuticals | Free Full-Text | Blood Pressure-Lowering Aspects of Lipid-Lowering and Anti-Diabetic Drugs | Notes
Several studies have shown that blood pressure can be lowered by the use of drugs that are not traditional antihypertensive drugs. This might be of clinical importance when many risk patients are treated by combination drug therapy in order to prevent cardiovascular disease by way of improving the cardiovascular risk factor profile.
PCR State-of-the-art lecture on 'The resurgence of renal denervation' | EurekAlert! Science News
Renal denervation (RDN) represents a device-based hypertension treatment intended to lower sympathetic activity. Only a few years ago, RDN was written off as ineffective after results of the sham-controlled SYMPLICITY HTN-3 trial failed to confirm early trials reports of significant BP reductions in patients resistant to guideline- based combination drug therapy.
Gladstone Researchers Find Method to Study Hidden HIV Reservoirs
PrEP | UNSW Newsroom
Combination Therapy may Lead to Greater Disease Burden in PAH Patients
FLOT Combination Therapy May Be a New Standard for Esophageal Cancer - Cancer Therapy Advisor
If I Have Both Lupus and MS, How Does My Doctor Know What Treatment To Use?
In my opinion immunosuppressant and anti-CD20 therapy (rituximab) is the preferred option for these patients. The actual therapy recommended will depend on the situation but could include periodic steroids, azathioprine, mycophenolate, cyclophosphamide or rituximab. A newer therapy for MS called teriflunimide (Aubagio) could be strongly considered as well because of its mechanism of action. Many patients end up on combination therapies that may include Copaxone plus one of the agents previously mentioned ...
Viral Load & T Cell Related Articles: Can We Really Count on T Cells?
Five years later, she saw the same doctor again after contracting a minor ear infection. During the course of her consultation the doctor (despite having been asked not to) told her that her previous CD4 count had been 26. As the readers may imagine, my friend was extremely upset and frightened at hearing this news. The doctor again tried to persuade her to start the ARVs, despite the fact that she had remained in good health for the more than five years since that count of 26 had been carried out. Instead she went to see a counselor who reminded her that she was as healthy the day after having been told her CD4 count had been 26 (five years previously), as she was the day before hearing the news. She declined the offer to go on combination therapy and 18 months later, remains in good health - nearly seven years after her blood counts indicated she had AIDS (according to the CDC definition) and more than 20 years after becoming "infected ...
GSK files EU regulatory submission for once-daily closed triple combination therapy FF/UMEC/VI for patients with COPD | GSK
When AIDS viruses are transmitted despite treatment » Science Abode
In principle, modern combination therapies are very effective at keeping AIDS causative agents in check. The treatment usually leads to a situation in which there is no longer any evidence of Human-Immunodeficiency Viruses (HIV) in the body. In this way, the drugs can also reduce the disease transmission rate to just one tenth. So why do new infections occur despite treatment?. Sperm containing a cocktail of viruses. The answer, according to findings recently published(*) by the Swiss researcher Sara Gianella Weibel and her American colleagues, is that other viruses also play a role. Working at the University of California in San Diego, the SNSF-funded scientist studied the semen of 114 HIV-infected men undergoing treatment who have sex with men. She found that the seminal fluid of 11 of the men contained a considerable quantity of HI viruses, even though the viral load of the blood of all of the men was very low. In eight of these 11 cases, Gianella Weibel also found evidence of various forms ...
Buy Balkatrin (Bactrim) Online
Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double‐Blind Randomized...
We found a large average difference in HSBP in favor of initial use of combination therapy compared with initial monotherapy across the first 8 months of the study (phases 1 and 2); there was no discernible subset of patients in whom this difference was not observed. It was largely due to the superiority of combination therapy in the first 16 weeks (phase 1), by margins of almost 8 and 10 mm Hg, respectively, for home and clinic systolic BP. Although combination therapy is expected to show superior efficacy and is recommended for stage 2 hypertension by some guidelines, this has not yet become the norm in routine practice. Consequently, we incorporated a number of planned measurements in the study design that we believed, if positive, would help to change practice.. The first of the additional measurements was the co-primary end point of HSBP at 32 weeks, the prespecified time point for evaluation of the never‐catch‐up hypothesis that initial less intense BP control results in subsequently ...
While erythromycin (EM) has been shown to play an anti-inflammatory role in COPD, it is unclear whether a combination of EM and corticosteroid would further reduce inflammatory effects. Here, we determined the molecular mechanisms by which combination therapy may repress inflammatory gene expression in monocytes. We demonstrated that combination treatment inhibited release of IL-8 in PBMCs of COPD patients and U937 exposed to CSE. ...
Two-Drug HIV Treatment Regimens Effective in Latest Studies - TheBodyPRO.com
Assessment of efficacy of oseltamivir-azithromycin combination therapy in prevention of influenza-a (H1N1) infection...
Expert Rev Respir Med. (https://www.ncbi.nlm.nih.gov/pubmed/32053044#) 2020 Feb 13. doi: 10.1080/17476348.2020.1730180. [Epub ahead of print] Assessment of efficacy of oseltamivir-azithromycin combination therapy in prevention of influenza-a (H1N1) infection complications and rapidity of symptom relief. Ishaqui AA
On combination pills, do you have to take pill at exact same time? I take my pill at 11pm, but sometimes take them at 10pm,...
Anxizam Plus in Punjabi ਵਰਤੋਂ, ਖੁਰਾਕ, ਬੁਰੇ ਪ੍ਰਭਾਵ, ਲਾਭ, ਪਰਸਪਰ ਪ੍ਰਭਾਵ ਅਤੇ ਚੇਤਾਵਨੀ - Anxizam Plus varton, khurak, bure prabhav,...
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Febrex Plus in Punjabi ਵਰਤੋਂ, ਖੁਰਾਕ, ਬੁਰੇ ਪ੍ਰਭਾਵ, ਲਾਭ, ਪਰਸਪਰ ਪ੍ਰਭਾਵ ਅਤੇ ਚੇਤਾਵਨੀ
Salbid Plus in Marathi उपयोग, डोसेज, दुष्परिणाम, फायदे, अभिक्रिया आणि सूचना
Effect of Initial Combination Therapy With Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, and Metformin on Glycemic Control...
Therapy with the initial combination of sitagliptin and metformin was assessed for efficacy and tolerability in patients with type 2 diabetes who had inadequate glycemic control with diet and exercise. In this study, all active treatments produced clinically meaningful reductions in A1C, FPG, and 2-h PPG compared with placebo, and the coadministration groups provided greater reductions relative to the individual monotherapies (compared at the same metformin dose). After reaching the nadir, the changes in A1C and FPG were relatively stable over 24 weeks in all active treatment groups. Greater proportions of patients achieved A1C targets with all active treatments relative to placebo, with the coadministration of sitagliptin and high-dose metformin getting about two-thirds of patients to the A1C goal of ,7%.. As with other antihyperglycemic agents (24), including sitagliptin (9,11), patients with more severe baseline hyperglycemia (i.e., A1C ≥9%) had the largest reductions with coadministration ...
Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension - Université Grenoble Alpes
BACKGROUND: Data on the effect of initial combination therapy with ambrisentan and tadalafil on long-term outcomes in patients with pulmonary arterial hypertension are scarce. METHODS: In this event-driven, double-blind study, we randomly assigned, in a 2:1:1 ratio, participants with World Health Organization functional class II or III symptoms of pulmonary arterial hypertension who had not previously received treatment to receive initial combination therapy with 10 mg of ambrisentan plus 40 mg of tadalafil (combination-therapy group), 10 mg of ambrisentan plus placebo (ambrisentan-monotherapy group), or 40 mg of tadalafil plus placebo (tadalafil-monotherapy group), all administered once daily. The primary end point in a time-to-event analysis was the first event of clinical failure, which was defined as the first occurrence of a composite of death, hospitalization for worsening pulmonary arterial hypertension, disease progression, or unsatisfactory long-term clinical response.
Combination Drug Therapy for AIDS Found to Control Blinding Eye Infection | National Eye Institute
Researchers at the National Institutes of Health have discoveredthat a combination of protease inhibitors and other anti-HIV drugsused to treat people with AIDS can prevent or delay the progression ofcytomegalovirus (CMV) retinitis, a potentially blinding eyecomplication of AIDS. A letter detailing these findings is publishedin the May 21, 1997 issue of the Journal of the American MedicalAssociation(JAMA).
Does Therapy of Latent Tuberculosis Take Too Long? | Topics in Evidence-Based Pharmacy Practice | AccessPharmacy | McGraw-Hill...
Sterling8 and colleagues in a recent non-inferiority trial published in the New England Journal of Medicine compared the efficacy of a 3-month therapy containing the combination of INH (900mg) plus rifapentine (900 mg), given once weekly under supervision, to the efficacy of a 9-month therapy with daily, self-administered INH (300mg). The main question was whether the efficacy and effectiveness of the combination therapy would be at least as good as INH alone. During the 33-month follow up in a total of 7731 subjects, the effectiveness analysis counted only 7 cases of tuberculosis in the combination-therapy group compared to 15 cases in the INH-only group (HR=0.38 (95% CI, 0.15 to 0.99)). Better adherence and fewer episodes of hepatotoxicity were observed in the shorter, supervised combination therapy than the INH alone therapy. Hypersensitivity however was more commonly associated with the combination of INH plus rifapentine. This trial suggests that the combination of rifapentin and INH could ...
Drug Combo Improves PAH
Results of a new 12-week study combining iloprost and bosentan showed improvements in patients with pulmonary arterial hypertension (PAH). University of Michigan Medical Center researchers followed 65 PAH patients being treated with the endothelian receptor antagonist bosentan. Thirty-two patients began taking inhaled iloprost in addition to bosentan; 33 received bosentan plus placebo. At the end of 12 weeks, the bosentan-iloprost group could walk 98 feet farther in their 6-minute walk test. Eleven of the 32 in the combination-therapy group showed improvement, and none of them showed signs of clinical deterioration. PAH is characterized by a progressive narrowing of the blood vessels in the lungs and can be fatal. Symptoms, which only get worse over time, include shortness of breath, fatigue, weakness, dizziness, and fainting. The report can be found in the December 2006 issue of the American Journal of Respiratory and Critical Care Medicine. Ms. Farley is a freelance medical writer based in ...
Evaluating Immunotherapy for Metastatic Breast Cancers - Vanderbilt Discover
Mayers latest research includes trials studying the effect of combination drug therapies in metastatic estrogen receptor-positive (ER+), endocrine therapy-refractory breast cancer and metastatic triple-negative breast cancer (TNBC) patients. The benefits could include a highly active therapy (without traditional chemotherapy) that increases overall survival, and possibly even cure rates in metastatic disease.. One of the drugs contains an anti-PD-L1 antibody known to work in 10-20 percent of patients; the second is a MEK inhibitor. Mayer believes the antibody will help unmask the tumor to the immune system and make the immunotherapy drug work better in a greater percentage of patients. "A unifying dogma is that estrogen-positive cancers are immunotherapy cold," she said. "Were hoping to prime the cancer to be more responsive.". Overall, the trials could help develop both predictive biomarkers of response and early (on-treatment) biomarkers of response, and with additional laboratory ...
Search Results for Basic Medical Science, Education, other | Sciendo
Salt sensitive hypertension is known to be a contributing factor for the progression of kidney disease. This study was undertaken to investigate the role of excessive dietary salt on renal function and to evaluate the effect of valsartan and amlodipin given as a combination therapy on blood pressure and parameters specific to the renal function in salt loaded SHR rats. 48 male SHR rats at age of 20 weeks and body weight ranging between 270-350 g were used. SHR rats were divided into 3 groups: control group of rats -SHRC (n = 16) given tab water ad libitum and two salt treated groups in which tab water was replaced with a solution of NaCl (1%) from age of 8 weeks given ad libitum: SHRVAL+AMLO group (n = 16) where investigated drugs were administered at a dose of 10 mg/kg/ b.w. (valsartan) and 5 mg/kg/ b.w. (amlodipin) by gavage and SHR NaCl group (n = 16) that received saline in the same volume and the same time intervals as the SHRVAL+AMLO group. For a period of 12 weeks we have investigated the ...
Search Results for Education, other | Sciendo
Salt sensitive hypertension is known to be a contributing factor for the progression of kidney disease. This study was undertaken to investigate the role of excessive dietary salt on renal function and to evaluate the effect of valsartan and amlodipin given as a combination therapy on blood pressure and parameters specific to the renal function in salt loaded SHR rats. 48 male SHR rats at age of 20 weeks and body weight ranging between 270-350 g were used. SHR rats were divided into 3 groups: control group of rats -SHRC (n = 16) given tab water ad libitum and two salt treated groups in which tab water was replaced with a solution of NaCl (1%) from age of 8 weeks given ad libitum: SHRVAL+AMLO group (n = 16) where investigated drugs were administered at a dose of 10 mg/kg/ b.w. (valsartan) and 5 mg/kg/ b.w. (amlodipin) by gavage and SHR NaCl group (n = 16) that received saline in the same volume and the same time intervals as the SHRVAL+AMLO group. For a period of 12 weeks we have investigated the ...
The Canadian Methotrexate and Etanercept Outcome Study: a randomised trial of discontinuing versus continuing methotrexate...
In this study, non-inferiority of ETN monotherapy compared with the ongoing combination of ETN and MTX, after 6 months of combination therapy in MTX-IRs, was not demonstrated. From 6 to 12 months, DAS28 was stable in patients on ETN+MTX and increased slightly in patients on ETN monotherapy. However, the mean difference between treatment groups was 0.45; thus, in some patients, the difference may not be clinically meaningful, whereas in others, their change in DAS28 after stopping MTX was clinically meaningful. One can potentially determine which patients may benefit from continuing MTX for the next 6 months vs stopping MTX. The subset of patients with LDA at 6 months achieved a similar DAS28 and EULAR response at 12 months whether on monotherapy or combination therapy. Conversely, patients with MHDA at 6 months performed better on combination therapy.. CAMEO, unlike other studies, focused on the disease state required to sustain ETN monotherapy regardless of the disease state at randomisation, ...
Dr Simon Gibbs Outlines Monotherapy vs Combination Therapy in Pulmonary Hypertension
The majority of patients with pulmonary arterial hypertension, except for a few special circumstances, will begin treatment on combination therapy, instead of monotherapy, because combination therapy has been shown in trials to ahve better outcomes, explained Simon Gibbs, MD, Reader in Pulmonary Hypertension at the National Heart and Lung Institute, Imperial College London.
Combination therapy may increase survival rates in brain cancer patients | Zee News
Combination Therapy May Reverse Venetoclax Resistance in Relapsed or Refractory AML
Publications and Presentations | UK HIV Drug Resistance Database
Wittkop L., Günthard HF, de Wolf F., Dunn DT, Cozzi-Lepri A, De Luca A., Kucherer C., Obel N., von Wyl V., Masquelier B. et al.. 2011. Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a European multicohort study. Lancet Infect Dis. 11:363-71. ...
Background Individuals with metastatic sarcoma who all improvement on vascular endothelial | Selective Inhibitors of Protein...
Background Individuals with metastatic sarcoma who all improvement on vascular endothelial development aspect receptor inhibitors (VEGFRi) have got limited treatment plans. these sufferers was 3.1 months which range from 0.5 to 7.2 a few months with one individual remaining on combination therapy. Bottom line In this intensely pre-treated, advanced sarcoma people, the addition of mTOR inhibition to VEGFRi structured therapy led to a clinical advantage for the subset of sufferers. Prospective research will be had a need to confirm these results. Launch Soft tissues and bone tissue sarcomas take into account significantly less than 1% of most adult malignancies . While improvements in therapy have already been made, MK-0679 median success after advancement of MK-0679 faraway metastases is certainly 11 to 15 a few months . Multiagent cytotoxic regimens possess demonstrated response prices which range from 16 to 46% within this people [3,4], nevertheless tolerability remains a problem. ...
Two Studies Document Rise of Superbugs in the Environment
Physicians need to be aware of the risk factors for MDR bacterial infections, Dr. Pop-Vicas said, and should be judicious in prescribing antibiotics. Treating infections caused by MDR bacteria is "a therapeutic challenge," Dr. Pop-Vicas said, because for severe infections, physicians may need to administer medicine before the bacterial culprit--and its potential resistance to antibiotics--is known. In such cases, combination antibiotic therapy (using more than one drug at a time) may be preferable to monotherapy (using one drug) because physicians want to "maximize the chance that the organism is sensitive to at least one of them," Dr. Pop-Vicas said. "Starting to treat an infection with inadequate therapy is associated with a worse outcome than using adequate therapy from the start," she added. Once the bacteriums drug resistance is known, the therapy can be adjusted accordingly ...
Impurity Testing of Fixed-Dose Combination Drugs | Chromatography Online
The Agilent 1290 Infinity II High Dynamic Range Diode Array Detection Impurity Analyzer Solution combines the signals from two diode array detectors with different path length Max-Light cartridge cells to increase the linear dynamic UV-range. This solution can be used to detect and quantify main and trace compounds in a single run without exceeding the linear UV-range.
CNN - New York man dies after supergerm infection - April 24, 1998
But still, there is some concern. For several years, doctors have been warning of the emergence of drug-resistant bacteria. The problem is attributed to overuse or misuse of antibiotics. An experimental French drug called Synercid could prove to be an effective new antibiotic against the resistant bug. In the meantime, many hospitals have restricted use of their most potent antibiotics, isolated their sickest patients and instructed staff members to wash their hands often. "Its of interest and concern because it represents an instance in which an effective antibiotic has become ineffective in treating a common organism," Adel said. People at greatest risk to the staph bacteria are those with weakened immune systems, including newborn babies, the elderly, and cancer and AIDS patients. Even though the New York patient was at high risk and he never got a chance to get combination antibiotic therapy, health officials are taking no chances at further infections. Hospitals will continue to follow ...
Pain Relief - Combination Drugs Score Over Mono-therapy
Global Glaucoma Therapeutics Market: Value Growth over Forecast Period Attributed to Strong Pipeline of Combination Drugs,...
Glaucoma Therapeutics Market: Scope and Methodology The research is a combination of primary and secondary research, conducted for understanding and arriving at trends, used to forecast the expected revenue of the major glaucoma therapeutics market in the near future. Primary research formed the bulk of our research efforts with information collected from in-depth interviews and…
2015 FC 959 - The Health Minister denied data protection for Cysview after finding it was not an "innovative drug", and the FC indicated the scope of "innovative drug" does not extend to combinations of the enumerated variations of previously approved medicinal ingredients in the Regulations (salt, ester, enantiomer, solvate or polymorph ...
How are drug regimen changes during hospitalisation handled after discharge: a cohort study | BMJ Open
This study has shown that extensive changes in drug regimens were made during these patients hospital stays. This is not surprising because hospitalised patients are often seriously ill or are experiencing deteriorations in chronic diseases. It is noteworthy that three-quarters of the patients were discharged with at least three changes to their drug regimens relative to their drug regimens at admission. The addition of new drugs markedly exceeded the number of drug discontinuations. Other studies have also reported that drug regimens are frequently changed during hospital stays.3 ,4 ,7 ,10 However, Himmel et al3 did not state whether the changes were continued until discharge from hospital, and in a one-day survey, Karapinar et al10 did not report whether these changes were maintained after discharge. Grimmsmann et al7 compared prescriptions during a 3-month period before admission and after discharge but did not relate the changes to the medication list at discharge. In comparison, we ...
Antiviral activity of nucleoside analogues during short-course monotherapy or dual therapy: Its role in preventing HIV...
Review: HCV Combo Tx Offers "Hint" Of Added Benefit - MPR
New Study Demonstrates Anti-Tumor Advantages for Combination Treatment Featuring Peregrine Pharmaceuticals' PS-Targeting...
M.D., Ph.D., evaluated the effects of combining PS-targeting, anti-PD-1 and radiation therapies in the mouse B16 melanoma model. Study data showed that PS-targeting antibodies synergize with both anti-PD-1 and radiation therapy to improve anti-cancer activity. PS-targeting treatment in combination with radiation, as well as triple combination of PS-targeting treatment, anti-PD-1 and radiation, led to a reduction in tumor burden. Median survival for the triple combination treatment still had not been reached at the end of the 80-day observation period with other arms in the study showing median survival that ranged from 24-70 days. Researchers also evaluated the impact of the PS-targeting and radiation combination treatment on the level and type of immune activity. These results demonstrated that the combination led to a change in the tumor microenvironment, shifting it from immunosuppressive in which tumors are protected to immune active in which tumors are more susceptible to treatment. ...
A PHASE II STUDY OF PRO143966 IN COMBINATION WITH Ro50-8231 AS A FIRST LINE THERAPY IN PATIENTS WITH MET-POSITIVE AND EGFR...
Behavior worsened after decrease in Vyvanase dosage, also taking Seroquel. Should I continue with the same dosage? - Doctor's...
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Blemish Relief Combination Therapy 90 Day Regimen - Perricone MD | MECCA
A Phase 3b, Multicenter, Randomized, Open-Label Study to Investigate the Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed...
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Which one do you like best? I personally find BigBrother stupid...who wants to watch people in a house all day? Plus, I dont like how it is like a talk-show at the same time. But I do like Survivor a lot http://www.SitePoint.com/forums/smile.gif ------------------ WebDevHQ.com - The Web Developer Headquarters
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Perucca, Emilio; Levy, René H. (2002). "Combination Therapy and Drug Interactions". In Levy, René H.; Mattson, Richard H.; ... Center for Drug Evaluation and Research. "Drug Interactions & Labeling - Drug Development and Drug Interactions: Table of ... Flockhart, DA (2007). "Drug Interactions: Cytochrome P450 Drug Interaction Table". Indiana University School of Medicine. ... also drugs that treat pain associated with ulcers, such as omeprazole, antiseizure drugs such as mephenytoin, the antimalarial ...
Postural orthostatic tachycardia syndrome
The two drugs had similar potencies; combination therapy was not significantly better than monotherapy.. ... Drug(s) Neuropathic POTS Alpha-1 adrenergic receptor agonist Constrict the peripheral blood vessels aiding venous return. ... POTS treatment involves using multiple methods in combination to counteract cardiovascular dysfunction, address symptoms, and ... Food and Drug Administration to treat POTS, but a variety are used off-label. Their efficacy has not yet been examined in ...
Metastatic breast cancer
A targeted therapy drug, Kadcyla, was approved in February 2013. This antibody-drug conjugate targets only cancerous cells. It ... Scheduling of drug treatments and combination treatment can have substantial impact on treatment efficacy. Nanomedicine is ... In most cases, however, the combination of radiotherapy and hormonal therapy is not enough to maintain disease control, and ... Chemotherapy is one of the most important components of therapy for metastatic breast cancer. Therapy of choice is based on ...
Disease-modifying antirheumatic drug
Some of the drugs can be used in combination. A common triple therapy for rheumatoid arthritis is methotrexate, ... Combinations of DMARDs are often used together, because each drug in the combination can be used in smaller dosages than if it ... "Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid ... Disease-modifying antirheumatic drugs (DMARDs) is a category of otherwise unrelated drugs defined by their use in rheumatoid ...
Christine L. Clouser
... have been found to cause lethal mutagenesis of the HIV-1 virus when used combination therapy. These two drugs are FDA approved ... and Steven Patterson found a novel combination therapy for rendering the HIV-1 virus harmless by using a combination therapy of ... "Christine L Clouser, PhD".  "Drug design success propels efforts to fight HIV with a combination of 2 FDA-approved drugs". ... "Exploiting Drug Repositioning for Discovery of a Novel HIV Combination Therapy". Journal of Virology. 84 (18): 9301-9308. doi: ...
"Drug Design, Development and Therapy. 9: 4219-4225. doi:10.2147/DDDT.S80713. ISSN 1177-8881. PMC 4531037. PMID 26345129.. ... Evidence-based reviews found that the most effective therapy for melasma includes a combination of topical agents. Triple ... tretinoin and a steroid component have shown to be more effective than dual combination therapy or hydroquinone alone. More ... Galvanic or ultrasound facials with a combination of a topical crème/gel. Either in an aesthetician's office or as a home ...
There are many drug therapies under study for neurofibromas. These are in various stages of research; more time will be ... The combination of erlotinib with sirolimus is being studied to treat low-grade gliomas. Early research has shown potential for ... Tipifarnib (also known as drug R115777) inhibits the activation of RAS. This drug is a Farnesyltransferase inhibitor which ... Therapy, and Patient Management" (PDF). Denver: Mountain States Genetic Foundation. Klesse, Laura (2010). "Current Therapies ...
A new combination drug therapy (sulfonamide, ceftriaxone, and amikacin) has also shown promise. The prognosis of nocardiosis is ... In patients who do not respond to sulfonamide treatment, other drugs, such as ampicillin, erythromycin, or minocycline, may be ... In patients with brain infection, mortality exceeds 80%; in other forms, mortality is 50%, even with appropriate therapy. It is ... cure rate with appropriate therapy. The cure rate falls to 63% with those infected with dissemented nocardiosis, with only half ...
... followed by drug therapy to prevent recurrence. Chorea gravidarum. haloperidol, chlorpromazine alone or in combination ... Chorea may also be caused by drugs (commonly levodopa, anti-convulsants and anti-psychotics). ... Tetrabenazine is the only FDA approved drug for the treatment of Huntington's Disease related chorea. ... Although there are many drugs that can control it, no cure has yet been identified. ...
Hepatitis C virus
There is also current experimental research on non drug related therapies. Oxymatrine, for example, is a root extract found in ... the FDA approved simeprevir for use in combination with peginterferon-alfa and ribavirin. Simeprevir has been approved in ... "Food and Drug Administration. Nov 22, 2013.. *^ "Medivir: Simeprevir has been approved in Japan for the treatment of genotype 1 ... It has been reported to be the first drug that has demonstrated safety and efficacy to treat certain types of HCV infection ...
"Combination Therapy for Acne Scarring: Personal Experience and Clinical Suggestions". Journal of Drugs in Dermatology (Review ... Combination therapy. Combination therapy-using medications of different classes together, each with a different mechanism ... "Drug Trials Snapshots: Aklief". U.S. Food and Drug Administration (FDA). 11 October 2019. Archived from the original on 19 ... Aslam I, Fleischer A, Feldman S (March 2015). "Emerging drugs for the treatment of acne". Expert Opinion on Emerging Drugs. 20 ...
Examples of indications for the drug include hormone therapy and hormonal contraception. In regards to the latter, estradiol ... cypionate is available as a combined injectable contraceptive in combination with medroxyprogesterone acetate. Along with ... The drug is a synthetic estrogen and hence is an agonist of the estrogen receptor (ER), the biological target of estrogens like ... Estradiol cypionate, sold under the brand name Depo-Estradiol among others, is a medication which is used in hormone therapy ...
Treatment of infection often involves a combination of antifungal drug therapy and surgical excision. Ochroconis gallopava was ... Also, antifungal drug therapy and surgical excision can be used to treat the infection separately or together. O. gallopava ... These drugs and surgical methods are the most effective when the fungus is yet disseminated into the brain. Survival rate of ... However, both antifungal drugs and surgical excision do not guarantee the perfect cure; there are some reported cases of ...
Today, a four drug combination therapy exists, but it takes six months or more to be effective. This requires a degree of ... At the present time, three of even four tuberculosis drugs are given as a combination therapy, over an extended period of time ... This poses a limitation for their use in combination therapy, for overcoming drug resistance. Also, some of the side effects ... This is one of the reasons why combination therapies are often essential for treating tuberculosis infections and most ...
Medicines for Malaria Venture
This poses a limitation for their use in combination therapy, for overcoming drug resistance. Also, some of the side effects ... This is one of the reasons why combination therapies are often essential for treating malarial infections and most infectious ... Under conditions of medical treatment, mutants that are resistant to the drug may escape the drug's action, survive and ... In 1999, the pipeline for new antimalarial drugs was virtually empty. The possibility of profit in antimalarial drug ...
The hormone production of the ovaries currently cannot be sufficiently mimicked by drug therapy. The ovaries produce hormones a ... or a combination. When the ovaries are removed, a woman is at a seven times greater risk of cardiovascular disease, but the ... Hormone therapy for women with oophorectomies performed before age 45 improves the long-term outcome and all-cause mortality ... Hormone replacement therapy does not always reduce the adverse effects. Oophorectomy is associated with significantly increased ...
The drug antibody eribulin combination therapy is a joint venture between Eisai and Merck. The clinical trials combine eribulin ... a liposomal formulation and antibody drug combination therapy, both are for the treatment of solid tumors. The liposomal ... Eribulin is an anticancer drug marketed by Eisai Co. under the trade name Halaven. Eribulin is also known as E7389 and ER- ... The mesylate salt was approved by the U.S. Food and Drug Administration on November 15, 2010, to treat patients with metastatic ...
Hormonal therapy may improve responses to antimyoclonic drugs in some people. Some studies have shown that doses of 5- ... Sodium valproate is an alternative therapy for myoclonus and can be used either alone or in combination with clonazepam. Some ... Some drugs being studied in different combinations include clonazepam, sodium valproate, piracetam, and primidone. ... and similar drugs, and is possibly a sign of high and/or rapidly increasing serum levels of these drugs. Myoclonic jerks caused ...
"Combination Antiretroviral Therapy". Drugs. 49 (Supplement 1): 32-37. doi:10.2165/00003495-199500491-00008. Waldholz, Michael ( ... During the mid-1990s, Lange began advocating for the use of combination therapy in the management of HIV/AIDS. He argued that ... He found that a baby's chance of contracting HIV falls to less than 1% if they receive anti-retroviral drugs while being nursed ... He was also a founding editor of the medical journal, Antiviral Therapy. In 2006 he became Professor of Medicine at the ...
... has become an important drug in the combination therapy for malaria treatment in Africa. It is often used in ... combination with artensunate as a by mouth artemisinin-based combination therapy (ACT) for uncomplicated P. falciparum malaria ... Expert opinion on drug safety. 6 (6): 631-5. doi:10.1517/14740318.104.22.1681. PMID 17967151. Profiles of Drug Substances, ... "Amodiaquine". drugs.com. Archived from the original on 27 November 2016. Retrieved 27 November 2016. Nair, A; Abrahamsson, B; ...
It became a key drug as part of the first combination therapy for treating AIDS. Realizing that this treatment could provide ... By exploring analogs to thymidine for use as antiviral drugs, his research created a new scientific paradigm for antiviral drug ... At the time, it was thought to be difficult to find antiviral drugs with a high therapeutic index, but professor Herbert E. ... The compound was originally named D4T, and Bristol-Myers Squibb developed and marketed this drug under its more common name, ...
Fexofenadine, an antihistamine drug used in treatment of allergies, has shown promise in a combination therapy in some studies. ... Raithel M, Winterkamp S, Weidenhiller M, Müller S, Hahn EG (July 2007). "Combination therapy using fexofenadine, disodium ... Helminthic therapy using the whipworm Trichuris suis has been shown in a randomized control trial from Iowa to show benefit in ... "Molecular Therapy. 18 (7): 1365-72. doi:10.1038/mt.2010.54. PMC 2911249. PMID 20389289.. ...
Affordable Medicines Facility-malaria
Stencel, Christine (20 July 2004). "Up to $500 Million Needed Annually for Subsidy to Make Artemisinin Combination Therapy the ... 225 million partnership to bring effective malaria drugs to all who need them". The Global Fund to Fight AIDS, Tuberculosis and ... artemisinin-based combination therapy, and the contribution of modeling to policy choices" (PDF). Am. J. Trop. Med. Hyg. 71 ( ... artemisinin-based combination therapies, ACTs). It works primarily through the commercial private sector, in addition to the ...
These are all antimalarial drugs and are stll used in artemisinin-combination therapy. After the fall of Saigon on 30 April ... As the first line strategy, the troops were given synthetic drugs. Drug combinations using pyrimethamine and dapsone, ... mechanisms of action and combination therapy of artemisinin". Expert Review of Anti-infective Therapy. 7 (8): 999-1013. doi: ... Their combination drugs are advocated by the World Health Organization, and are included in the World Health Organization's ...
Treatment trials test experimental drugs, new combinations of drugs, or new approaches to surgery or radiation therapy. ... "Investigational New Drug (IND) Application - Final Rule: Investigational New Drug Safety Reporting Requirements for Human Drug ... what the drug does to the body) and pharmacokinetics (what the body does to the drugs). For a test drug, the trial ... Some drug trials require patients to have unusual combinations of disease characteristics. It is a challenge to find the ...
Hope Clinic Lukuli
The new Artemisinin-based Combination Therapy (ACT) drug available in Uganda under the facility is called Coartem. It is ... Drugs shops who feel they have exhausted their medical treatment or diagnosis capacity can refer patients for a check-up. The ... The credit line amounts to only 10% of monthly drug costs but the clinic has applied it to the various items used for maternity ... A smaller amount was deposited by the city council to the Joint Medical Stores from whom we procure our drugs and medical ...
Toca 511 and Toca FC
... is a combination drug involving a gene therapy agent and a prodrug. It is a candidate drug to treat brain ... The combination drug was designed to be used after a brain tumor is removed surgically; Toca 511 is intended to be injected ... By July 2017 the EMA had granted the combination priority review status, and the FDA had granted it Breakthrough Therapy ... The combination is under development by Tocagen and as of July 2017 phase 2/3 trials were underway for recurrent astrocytoma ...
Among these are the water-soluble coenzyme Q10 formulation, the prescription drug Tanakan, and combination antioxidant therapy ... Antioxidant therapy - age-related hearing loss was reduced in animal models with a combination agent comprising six antioxidant ... Heman-Ackah et.al., Selena (Sep 2010). "A combination antioxidant therapy prevents age-related hearing loss in C57BL/6 mice". ... They may include: Ototoxic drugs: Ingestion of ototoxic drugs like aspirin may hasten the process of presbycusis. vascular ...
Type 2 diabetes
"Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta- ... Izzedine H, Launay-Vacher V, Deybach C, Bourry E, Barrou B, Deray G (November 2005). "Drug-induced diabetes mellitus". Expert ... The development of type 2 diabetes is caused by a combination of lifestyle and genetic factors. While some of these ... In those with impaired glucose tolerance, diet and exercise either alone or in combination with metformin or acarbose may ...
It is normally used as one of the three drugs in a triple-combination therapy for the HIV virus. ... It is soluble white powder administered orally in combination with other antiviral drugs. The drug prevents protease from ... After 38 weeks, 6% of the people in the three-drug group died while 11% of the people died in the two-drug group. There were ... Viral resistance to the drug leads to the drug becoming useless since the virus evolves to have cells that are able to resist ...
This condition is called "sarcopenia". The exact cause of sarcopenia is unknown, but it may be due to a combination of the ... amino acid therapy may be helpful for regenerating damaged or atrophied muscle tissue. The branched-chain amino acids or BCAAs ... A novel class of drugs, called SARM (selective androgen receptor modulators) are being investigated with promising results. ... a new approach for muscle wasting therapy?". Clinical Nutrition. 26 (5): 658-61. doi:10.1016/j.clnu.2007.07.003. PMID 17904252 ...
Positron emission tomography
PET has an expanding role as a method to assess the response to therapy, in particular, cancer therapy, where the risk to ... drug occupancy at a purported site of action can be inferred indirectly by competition studies between unlabeled drug and ... Combination of PET with CT or MRIEdit. Main articles: PET-CT and PET-MRI ... Pharmacokinetics: In pre-clinical trials, it is possible to radiolabel a new drug and inject it into animals. Such scans are ...
"U.S. Food and Drug Administration (FDA).. *Ebola: What You Need to Know - Scientific American articles related to Ebola; note ... "Experimental therapies: growing interest in the use of whole blood or plasma from recovered Ebola patients (convalescent ... The combination of severe vomiting and diarrhoea often leads to severe dehydration. Next, shortness of breath and chest ... "U.S. Food and Drug Administration (FDA) (Press release). 14 October 2020. Retrieved 14 October 2020.. This article incorporates ...
This drug may have some utility in transplants involving incompatible blood groups. It is also used as induction therapy in ... Hepatitis E infection is normally an acute infection, suggesting the drug in combination with lymphoma may have weakened the ... Rituximab Information from the US Food and Drug Administration. *U.S. National Library of Medicine: Drug Information Portal - ... In 2014 Genentech reclassified rituxan as a specialty drug, a class of drugs that are only available through specialty ...
Hematopoietic stem cell transplantation
Drug risks. Filgrastim is typically dosed in the 10 microgram/kg level for 4-5 days during the harvesting of stem cells. ... Lunzen, J.; Fehse, B.; Hauber, J. (2011). "Gene Therapy Strategies: Can We Eradicate HIV?". Current HIV/AIDS Reports. 8 (2): 78 ... In allogeneic transplants a combination of cyclophosphamide with total body irradiation is conventionally employed. This ... Immunosuppressive drugs are given for a minimum of 6-months after a transplantation, or much longer if required for the ...
Healthcare in Brazil
In 1998, the National Drug Policy was approved, whose purpose is to ensure safety, efficacy, and quality of drugs, as well as ... In the area of diagnostic support and therapy, 95% of the 7,318 establishments were also private. 73% of the 41,000 ambulatory ... Pre-hospital emergency medical services use a combination of basic ambulances staffed by technicians and advanced units with ... In 2000, there were 14 industries authorized to produce generic drugs and about 200 registered generic drugs were being ...
"Synthroid (Levothyroxine Sodium) Drug Information: Uses, Side Effects, Drug Interactions and Warnings". RxList. Archived from ... therapy should be continued during pregnancy. Furthermore, therapy should be immediately administered to women diagnosed ... Combination of levothyroxine with ketamine may cause hypertension and tachycardia; and tricyclic and tetracyclic ... "International Drug Price Indicator Guide. Retrieved 8 December 2016.. *^ Hamilton, Richart (2015). Tarascon Pocket ...
... or prescribe pharmaceutical drugs or other therapies. Differential diagnosis methods help to rule out conditions based on the ... In recent centuries, since the advent of modern science, most medicine has become a combination of art and science (both basic ... Pharmacology is the study of drugs and their actions.. *Photobiology is the study of the interactions between non-ionizing ... Medical nutrition therapy is done by dietitians and is prescribed for diabetes, cardiovascular diseases, weight and eating ...
... overlaps with several other forms of manual therapy, including massage therapy, osteopathy, physical therapy, and ... that the use of spine manipulation in clinical practice is a cost-effective treatment when used alone or in combination with ... American chiropractors found that a slight majority favored allowing them to write prescriptions for over-the-counter drugs.[37 ... The main chiropractic treatment technique involves manual therapy, especially spinal manipulation therapy (SMT), manipulations ...
The authorities also recognize that some devices are provided in combination with drugs, and regulation of these combination ... The precipitant for change was a radiation therapy device (Therac-25) that overdosed patients because of software coding errors ... U.S. Food and Drug Administration. Retrieved 2010-10-15.. *^ "Title 21-Food and drugs: Chapter i-Food and drug administration: ... U.S. Food and Drug Administration. Retrieved 2010-10-15.. *^ a b c d e f "General and Special Controls". Medical Devices. U.S. ...
Treatment may include some combination of surgery, radiation therapy and chemotherapy. Anticonvulsant medication may be ... The toxicity and many side effects of the drugs, and the uncertain outcome of chemotherapy in brain tumors puts this treatment ... Experimental treatments include targeted therapy, gamma knife radiosurgery, boron neutron capture therapy and gene therapy. ... Radiation therapyEdit. The goal of radiation therapy is to kill tumor cells while leaving normal brain tissue unharmed. In ...
"Journal of Physical Therapy Science. 28 (9): 2482-2485. doi:10.1589/jpts.28.2482. ISSN 0915-5287. PMC 5080157. PMID 27799675.. ... "Men Just Weren't Made to do This: Performances of Drag at 'Walk a Mile in Her Shoes' Marches." Gender and Society, vol. 24, no ... The 1790s continued this trend, but added combinations of color. Additionally, throughout all of these decades, there was no ... "Journal of Physical Therapy Science. 28 (3): 956-959. doi:10.1589/jpts.28.956. ISSN 0915-5287. PMC 4842473. PMID 27134392.. ...
David E. Golan (2008). Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Lippincott Williams & Wilkins. ... Castration may be used alone or in combination with one of the other two treatments. When castration is combined with a ... Androgen receptor antagonists: drugs that bind directly to and block the AR. These drugs include the steroidal ... Katsambas AD, Dessinioti C (2010). "Hormonal therapy for acne: why not as first line therapy? facts and controversies". Clin. ...
Baytop, T. (1999) Therapy with medicinal plants in Turkey, Past and Present. Kitapevi, Istanbul, Turkey, 2nd edition, pp. 142. ... "Consolidated federal laws of canada, Food and Drug Regulations". laws.justice.gc.ca. Retrieved 2018-07-19.. ... alone or in combination with other aromatic herbs), as well as in a wide variety of regional and ethnic confectioneries, ... Anise can be made into a liquid scent and is used for both drag hunting and fishing. It is put on fishing lures to attract fish ...
Carbons with a combination of macropores and mesopores adsorb tannins. The ability of a carbon to adsorb tannins is reported in ... Tablets or capsules of activated carbon are used in many countries as an over-the-counter drug to treat diarrhea, indigestion, ... Activated carbon, in 50% w/w combination with celite, is used as stationary phase in low-pressure chromatographic separation of ...
Occupational health psychology
labeled the combination of high levels of demands, low levels of control, and low levels of coworker support "iso-strain." The ... advantages of therapy with beta-receptor blockers. Clinical and Experimental Hypertension. Part A, Theory and Practice, 7(7), ... 2012) found that, controlling for other risk factors, the combination of high levels of demands and low control at baseline ... Meta-analytic research also links job strain (the combination of high demands and low control) to stroke. ...
Sex reassignment surgery
Further in the future, stem cell biotechnology may also make this possible, with no need for anti-rejection drugs. ... Sex reassignment surgery can be difficult to obtain, due to a combination of financial barriers and lack of providers. An ... After sex reassignment surgery, transsexuals (people who underwent cross-sex hormone therapy and sex reassignment surgery) tend ... which was caused by the testosterone therapies, or the withdrawal of gender dysphoria. ...
Antidepressive drug therapy, suicidal ideation and suicide, 2 cases reported in connection with moclobemide (Aurorix) therapy ... Hilton SE, Maradit H, Möller HJ (1997). "Serotonin syndrome and drug combinations: focus on MAOI and RIMA". Eur Arch Psychiatry ... An update on drug interactions". Drug Saf. 14 (4): 219-27. doi:10.2165/00002018-199614040-00002. PMID 8713690.. ... Serotonin syndrome has been reported when moclobemide has been taken in combination with other serotonin enhancing drugs; ...
... is used in some medical hospitals, cancer centers, schools, alcohol and drug recovery programs, psychiatric ... The combination of music and MMS helps premature infants sleep and conserve vital energy required to gain weight more rapidly. ... Types of music therapyEdit. There are two fundamental types of music therapy: receptive music therapy and active music therapy ... including Therapy in Music for Handicapped Children, Creative Music Therapy, Music Therapy in Special Education, as well as ...
FDA approved therapies for the treatment of fibromyalgia include Cymbalta (duloxetine hydrochloride), Lyrica (pregabalin), and ... Holtorf condones treating hypothyroidism with compounded combinations of bioidentical thyroid hormones. Chronic Fatigue ... Nonsteroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants. In contrast, Dr Holtorf advocates a controversial six step ... Gardner, Amanda (2009-01-30). "The Truth About 'Bio-identical' Hormone Therapy". US News and World Report. Retrieved 2011-11-26 ...
May 2008). "Effect of gene therapy on visual function in Leber's congenital amaurosis". N. Engl. J. Med. 358 (21): 2231-9. doi: ... They use a combination of vision and other senses to learn, although they may require adaptations in lighting or the size of ... become blind from incorrect diagnosis and from ineffectual prescription of drugs, antibiotics or steroids. In addition, ... A 2008 study tested the effect of using gene therapy to help restore the sight of patients with a rare form of inherited ...
U.S. Food and Drug Administration 14. Appendix F(mg) *^ Dietary Reference Intakes (DRIs): Elements Food and Nutrition Board, ... Schlenker, Eleanor; Gilbert, Joyce Ann (28 August 2014). Williams' Essentials of Nutrition and Diet Therapy. Elsevier Health ... a combination of vitamins and/or other chemical compounds, or a single element (as a compound or mixture of compounds), such as ...
PediaSIM HPS also responds to drug administration with a unique Drug Recognition System that uses barcode technology. New ... Oxygen therapy. *Anatomical features: responsive pupils, articulated mandible, exhalation of air and CO2, secretions from eyes ... human or a combination of the two, educational documents with detailed simulated animations, casualty assessment in homeland ... interfaces with real clinical monitors and responds to oxygen therapy. The optional anesthesia delivery system allows the lungs ...
Knee cartilage replacement therapy
Due to a combination of acute stress and chronic fatigue, osteoarthritis directly manifests itself in a wearing away of the ... This treatment has been approved by the Food and Drug Administration in 2016 for adult treatment only. Autologous matrix- ... Meniscal cartilage replacement therapy Meniscus transplant "FDA approves first autologous cellularized scaffold for the repair ... is a biological treatment option for articular cartilage damage bone marrow stimulating technique in combination with a ...
多囊卵巢綜合症 - 维基百科，自由的百
Many women with normal levels may benefit from combination therapy. A hypoglycemic response in which the two-hour insulin level ... Rasgon N. The relationship between polycystic ovary syndrome and antiepileptic drugs: a review of the evidence. J Clin ... Feig, Denice S.; Moses, Robert G. Metformin Therapy During Pregnancy Good for the goose and good for the gosling too?. Diabetes ... Balen A. Metformin therapy for the management of infertility in women with polycystic ovary syndrome (PDF). Scientific Advisory ...
In 2019, a triple-combination therapy, with dolutegravir replacing efavirenz, was introduced as the first-line treatment for ... "FDA Approves Drug to Treat Infants and Children with HIV". U.S. Food and Drug Administration (FDA) (Press release). 12 June ... "Drug Approval Package: Tivicay (dolutegravir) Tablets NDA #204790". U.S. Food and Drug Administration (FDA). 13 September 2013 ... "Drugs.com. Retrieved 20 April 2019.. *^ World Health Organization (2019). World Health Organization model list of essential ...
Index of HIV/AIDS-related articles
... multi-drug rescue therapy - multiple drug-resistant tuberculosis (MDR-TB) - mutation - myalgia - mycobacterium - mycobacterium ... combination therapy - community planning - Community Programs for Clinical Research on AIDS (CPCRA) - community-based clinical ... antiretroviral drugs - antisense drugs - antitoxins - Antiviral drug - aphasia - aphthous ulcer - apoptosis - approved drugs - ... drug resistance - drug-drug interaction - DSMB - Duffy antigen system - dysplasia - dyspnea ...
Study Shows Combination Drug Therapy for Asthma Patients Is Safe
Food and Drug Administration has shown that a combination drug therapy for the treatment of asthma is safe and effective. ... A post-marketing safety study mandated by the U.S. Food and Drug Administration has shown that a combination drug therapy for ... Two asthma-related deaths were reported in the combination arm of the study and none in the single-therapy group, which is not ... 8/31/2016http://www.wakehealth.edu/News-Releases/2016/Study_Shows_Combination_Drug_Therapy_for_Asthma_Patients_Is_Safe.htm ...
Combination Therapy May Combat Deadly Drug-Resistant Bacteria | BIDMC of Boston
... may have potent activity against drug-resistant bacteria when used in combination. ... Combination Therapy May Combat Deadly Drug-Resistant Bacteria. Jacqueline Mitchell (BIDMC Communications) 617-667-7306, ... Most drugs were effective in combinations when used in standard doses. Also, no combinations demonstrated antagonism, or ... The studys methods draw on the researchers previous findings that combination therapy may be effective even when bacteria ...
Pain Relief - Combination Drugs Score Over Mono-therapy
... scientists are relying more on combined analgesics rather than sticking to mono therapy. ... Drug Toxicity. Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, ... Drug Toxicity Drugs Banned in India Thoracic Outlet Syndrome Exercising Tips For Nerve Pain Relief Top 15 Natural Painkillers ... Drugs Banned in India. Several drugs are either banned or withdrawn after introduction in the market. ...
Combination Drug Therapy for AIDS Found to Control Blinding Eye Infection | National Eye Institute
Researchers at the National Institutes of Health have discoveredthat a combination of protease inhibitors and other anti-HIV ... Combination Drug Therapy for AIDS Found to Control Blinding Eye Infection. Archived Page. The information on this page is ... Home , News , Pressreleases , Combination Drug Therapy for AIDS Found to Control Blinding Eye Infection ... This new drug therapy may lead to asignificant improvement in the quality of life for people with AIDSwho have CMV retinitis." ...
Combination Therapy or Single Drug for CLL Treatment? - Leukemia Center - Everyday Health
My doctor wanted me to use a combination of drugs to treat my CLL, but I chose to go with just one because of side effects. Was ... Chemo-Free Drug Combination Tops Standard Chemotherapy for Treating Chronic Lymphocytic Leukemia (CLL). Nearly 85 percent of ... At that point my doctor treated me with a combination of Rituxan and Cytoxan. This brought the white count to 3,700. My last ... At this point, my doctor wanted to continue treatments with the Cytoxan/Rituxan combination for another three treatments. He ...
Materials | Free Full-Text | A Natural Bacterium-Produced Membrane-Bound Nanocarrier for Drug Combination Therapy
This study reveals that this new system has a potential for drug delivery application in the future, especially for combination ... The Ara-C drug continued to release about 85% within 40 days, while DNR release lasted only for 13 days. Moreover, similar to ... The results show that this new system is stable and exhibits optimal drug-loading properties. The average diameters of BMs and ... The optimal encapsulation efficiency and drug loading of Ara-C were 68.4% ± 9.4% and 32.4% ± 2.9%, respectively, and those of ...
Combination Drug Therapy for Patients With Hepatitis C
Combination of Alpha Interferon With Long Term Ribavirin Therapy for Patients With Chronic Hepatitis C. Trial Phase:. Phase 3. ... stopping therapy. Patients must not have received the combination of alpha interferon and. ribavirin in the past.. ... combination therapy, patients will be seen in the outpatient clinic for medical interview,. physical examinations and blood ... combination of alpha interferon and ribavirin for 12 months with early discontinuation of. therapy and randomization to receive ...
Combination Antihypertensive Drug Therapy: A Therapeutic Option Long Overdue - Editorials - American Family...
What does all of this have to do with combination drug therapy? Plenty. Therapy with the low to moderate doses of the two drugs ... The move to combination antihypertensive drug therapy, even as initial therapy, in high-risk patients with hypertension ( ... Combination antihypertensive drug therapy has long been an infrequently exercised therapeutic option in the difficult battle to ... 10(May 15, 2000) / Editorials: Combination Antihypertensive Drug Therapy: A Therapeutic Option Long Overdue ...
Global Cephalosporin Drugs Market 2015-2019 - Use of Combination Therapies
The increased approvals and use of combination drugs is an emerging trend in the global cephalosporin drugs market. Combination ... This can be avoided by the judicious use of combination drugs.. According to the report, the increased awareness of diseases ... the report considers revenue generated from the sales of various prescription drugs along with the generic drugs used for the ... Some drugs that have expired and have a generic form as of today include cefuroxime axetil, ceftazidime, and cefprozil.. Key ...
Malaria combination drug therapy for children
A drug combination of artemisinin-naphthoquine should be considered for the treatment of children with uncomplicated malaria in ... medicalxpress.com/news/2014-12-malaria-combination-drug-therapy-children.html This document is subject to copyright. Apart from ... A drug combination of artemisinin-naphthoquine should be considered for the treatment of children with uncomplicated malaria in ... Combination drug treatment can cut malaria by 30 percent. Apr 02, 2012 ...
Head Lice Infestation: Single Drug Versus Combination Therapy With One Percent Permethrin and Trimethoprim/Sulfamethoxazole |...
Although dual therapy with 1% PER and TMP/SMX is a more expensive therapy compared with a single drug regimen, the parents ... Head Lice Infestation: Single Drug Versus Combination Therapy With One Percent Permethrin and Trimethoprim/Sulfamethoxazole. ... Head Lice Infestation: Single Drug Versus Combination Therapy With One Percent Permethrin and Trimethoprim/Sulfamethoxazole ... Head Lice Infestation: Single Drug Versus Combination Therapy With One Percent Permethrin and Trimethoprim/Sulfamethoxazole ...
Combination drug therapy shrinks pancreatic tumors in mice - Healthcanal.com : Healthcanal.com
A combination of two drugs, one already approved by the Food and Drug Administration, appears to be effective at shrinking ... "So Pawel had the idea to look for drug combinations that might have a synergistic effect." Mazur tried eight drugs in ... Alternative Therapies*Drugs Approvals and Trials*Environmental Health*Health Informatics*Legal and Regulatory*Life style and ... Although this protein, and others that work with it in the Ras pathway, would appear to be a perfect target for therapy, drugs ...
Combination drug therapy effectively treats male infertility
... data are lacking on the use of combination CC+AZ therapy. ... Two drugs that are commonly used off-label in the treatment of ... Combination drug therapy effectively treats male infertility. by Wiley Two drugs that are commonly used off-label in the ... AZ therapy. A new BJU International study found that combination CC+AZ therapy is safe and effective for patients with elevated ... medicalxpress.com/news/2018-06-combination-drug-therapy-effectively-male.html This document is subject to copyright. Apart from ...
Four-Drug Combination Treatment in Hiv-Infected Subjects Failing Therapy With Antiretroviral Regimens - Tabular View -...
Four-Drug Combination Treatment in Hiv-Infected Subjects Failing Therapy With Antiretroviral Regimens. The safety and ... Four-Drug Combination Treatment in Hiv-Infected Subjects Failing Therapy With Antiretroviral Regimens. ... the pharmacokinetic drug-drug interactions between capravirine and Kaletra and selected concomitant medications ... To determine the optimal safe and effective dose of capravirine in combination with Kaletra plus at least 2 NRTIs ...
Leukemia Drug offers hope as Combination Therapy for Resistant Subtype
Now researchers have expanded its use to drug-resistant T-cell prolymphocytic leukemia. ... The drug cladribine offered hope for people leukemia in the past. ... Other treatments for T-PLL include combining alemtuzumab with the drug pentostatin, the FMC drug combination (fludarabine, ... the drug combination may move more quickly out of the trial phase and into practice due to the fact that both drugs are already ...
Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial. FIN-RACo trial...
195 started the treatment (97 received combination and 98 single drug therapy). Single-drug therapy in all patients started ... Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial. FIN-RACo trial ... After a year, remission was achieved in 24 of 97 patients with combination therapy, and 11 of 98 with single-drug therapy (p= ... patients with combination therapy, and in 56 (60%) using single-drug therapy (p=0.028), while at the 2-year visit 69 and 57 ...
Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia - Full Text View -...
Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia. The safety and ... Girls in group one will take the four drug combination until the age of 13, at which time they will stop and begin receiving ... Group one will receive the new four- drug combination. Group two will receive the standard treatment for congenital adrenal ... This study was developed to determine if a combination of four drugs (flutamide, testolactone, reduced hydrocortisone dose, and ...
Four-Drug Combination Treatment in Hiv-Infected Subjects Failing Therapy With Antiretroviral Regimens - No Study Results Posted...
Xeloda Combination Therapy in Esophagogastric Cancer Highlighted in New England Journal of Medicine - Drugs.com MedNews
Study Demonstrates Oral Xeloda Combination is a Comparable Alternative to All-Intravenous Therapy - Data published in this week ... Home › News › Clinical Trials › Xeloda Combination Therapy in Esophagogastric Cancer Highlighted in New England Journal of ... Xeloda Combination Therapy in Esophagogastric Cancer Highlighted in New England Journal of Medicine. Print this page ... Drugs.com Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ...
topic:"Drug Therapy, Combination" found 1240 records • Arctic Health
Asthma - drug therapy - physiopathology Canada Chronic Disease Double-Blind Method Drug Therapy, Combination Drug Tolerance ... Arthritis, Rheumatoid - complications - drug therapy Canada Clinical Trials as Topic Drug Approval Drug Therapy, Combination ... Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Female Humans Hypertension - drug ... Drug Therapy, Combination Female Humans Male Middle Aged Nausea - drug therapy - etiology Ondansetron - administration & dosage ...
A Study to Evaluate the Safety and Tolerance of Combination Anti-HIV Drug Therapy (Indinavir, Lamivudine, and Zidovudine) in...
Drug Therapy, Combination. Zidovudine. HIV Protease Inhibitors. Lamivudine. Indinavir. Disease Transmission, Vertical. Anti-HIV ... A Study to Evaluate the Safety and Tolerance of Combination Anti-HIV Drug Therapy (Indinavir, Lamivudine, and Zidovudine) in ... The purpose of this study is to determine if a combination anti-HIV drug treatment regimen of indinavir plus lamivudine (3TC) ... The combination of drugs in this study may be more effective than ZDV alone. ...
Conjugated polymer and drug co-encapsulated nanoparticles for Chemo- and Photo-thermal Combination Therapy with two-photon...
Herein, we developed a chemotherapeutic drug doxorubicin (DOX) and photothermal conjugated polymer (CP) co-loaded nanoplatform ... The spatial-temporal synchronization of photothermal therapy and chemotherapy is highly desirable for an efficient cancer ... Conjugated polymer and drug co-encapsulated nanoparticles for Chemo- and Photo-thermal Combination Therapy with two-photon ... Conjugated polymer and drug co-encapsulated nanoparticles for Chemo- and Photo-thermal Combination Therapy with two-photon ...
Cerebral Therapeutics Raises Series A Financing to Advance Clinical-Stage Drug-Device Combination Therapy for Adult Refractory...
a clinical-stage company focused on implanted drug-device combination therapies to improve the lives of patients with ... drug-device combination therapies to improve the lives of patients with uncontrolled neurological diseases, announced today the ... Cerebral Therapeutics Raises Series A Financing to Advance Clinical-Stage Drug-Device Combination Therapy for Adult Refractory ... the Company is pioneering the development of long-term implanted drug-device combination therapies that bypass the blood-brain ...
Experimental breast cancer drug holds promise in combination therapy for Ewing sarcoma - Healthcanal.com : Healthcanal.com
A clinical trial using the three-drug combination therapy detailed in this research is expected to open later this year for ... Experimental breast cancer drug holds promise in combination therapy for Ewing sarcoma. ... Alternative Therapies*Drugs Approvals and Trials*Environmental Health*Health Informatics*Legal and Regulatory*Life style and ... The therapy will pair the PARP inhibitor olaparib with the chemotherapy drugs irinotecan (IRN) and temozolomide (TMZ). ...
Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic...
Secondly, Graudal grouped conventional synthetic DMARD combination therapy according to the number of drugs (two or three), ... A trial of conventional synthetic DMARD combination therapy before biologic therapy is not recommended by either major ... reserving combination therapy for if they fail to respond adequately. Triple therapy was also associated with an increase in ... Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for ...
Tumour necrosis factor inhibitors versus combination intensive therapy with conventional disease modifying anti-rheumatic drugs...
Tumour necrosis factor inhibitors versus combination intensive therapy with conventional disease modifying anti-rheumatic drugs ... Tumour necrosis factor inhibitors versus combination intensive therapy with conventional disease modifying anti-rheumatic drugs ... Tumour necrosis factor inhibitors versus combination intensive therapy with conventional disease modifying anti-rheumatic drugs ... Tumour necrosis factor inhibitors versus combination intensive therapy with conventional disease modifying anti-rheumatic drugs ...
Experimental breast cancer drug holds promise in combination therapy for Ewing sarcoma - St. Jude Children's Research Hospital
Jude Childrens Research Hospital researchers have identified a promising new triple-drug combination therapy that exploits DNA ... Jude Childrens Research Hospital researchers have identified a promising new triple-drug combination therapy that exploits DNA ... Experimental breast cancer drug holds promise in combination therapy for Ewing sarcoma Memphis, Tennessee, October 23, 2014 ... A clinical trial using the three-drug combination therapy detailed in this research is expected to open later this year for ...
New drug combination therapy developed to treat leukemia - VCU Massey Cancer Center
New drug combination therapy developed to treat leukemia. A new, pre-clinical study by researchers at Virginia Commonwealth ... Home / About Massey / News center / 2013 Archive / New drug combination therapy developed to treat leukemia ... New drug combination disrupts leukemia cells in preclinical studies. *Massey director awarded $3.2M to inform the development ... VCU Massey Cancer Center finding could open doors to creating new combination therapies for an aggressive form of breast cancer ...
Monitoring and Deterring Drug-Resistant Malaria in the Era of Combination Therapy | The American Journal of Tropical Medicine...
Genomic approaches may help identify molecular markers for resistance to artemisinins and their partner drugs. Studies of ... drug-resistant malaria must be updated and optimized. In vitro methods for measuring resistance will be critical for confirming ... are replaced by more effective artemisinin-based combination therapies (ACTs), strategies for monitoring (and, if possible, ... f Monitoring and Deterring Drug-Resistant Malaria in the Era of Combination Therapy * Miriam K. Laufer1, Abdoulaye A. Djimdé1, ...
Combination Therapy Provides Similar Clinical Benefit as Single Drug Treatment in People with MS - The Mount Sinai Hospital
Combination Therapy Provides Similar Clinical Benefit as Single Drug Treatment in People with MS. Drugs taken together do not ... The results showed that while combination therapy was no better than monotherapy, patients who took combination therapy had a ... who were treated with combination therapy did not see significant clinical benefit over those treated with single drug therapy ... Home , Service Areas , Neurology , News , Combination Therapy Provides Similar Clinical Benefit as Single Drug Treatment in ...
Antiretroviral drugEffectiveStudy2017MalariaTumorsRheumatoid arthritisACTs2018TherapeuticClinical trialsTargetsRegimensCancersResearchersAntihypertensive drugEffectiveDMARDsMutationsEfficacy and tolerability of combinationCancerEfficaciousEpigeneticAdverseMultiple sclerosisAnti-HIV drugFindingsInhibitorSynergisticProgressionInterventionPathwaysTumorMultidrugSearchInfectionsAnticancerDevelopmentAntimicrobial therapyOptimizationRemission
- A drug combination of artemisinin-naphthoquine should be considered for the treatment of children with uncomplicated malaria in settings where multiple parasite species cause malaria according to Tim Davis from University of Western Australia, Fremantle, Australia and colleagues in new research published in this week's PLOS Medicine . (medicalxpress.com)
- The authors compared the current recommended therapy for uncomplicated malaria in children in Papua New Guinea, artemether-lumefantrine, with a different combination therapy, artemisinin-naphthoquine. (medicalxpress.com)
- As chloroquine and sulfadoxine-pyrimethamine (SP) are replaced by more effective artemisinin-based combination therapies (ACTs), strategies for monitoring (and, if possible, deterring) drug-resistant malaria must be updated and optimized. (ajtmh.org)
- Treatment of malaria in HIV-infected individuals receiving antiretroviral therapy (ART) poses significant challenges. (hindawi.com)
- Artemether-lumefantrine (AL) is one of the artemisisnin-based combination therapies recommended for treatment of malaria. (hindawi.com)
- The drug combination is highly efficacious against sensitive and multidrug resistant falciparum malaria. (hindawi.com)
- Current guidelines for malaria treatment advocate use of artemisinin-based combination therapies (ACTs). (hindawi.com)
- Treatment of malaria in HIV-infected individuals receiving ART poses significant challenges with gaps in the knowledge of ART and ACT drug-drug interactions and their consequences. (hindawi.com)
- In Tanzania, many people seek malaria treatment from retail drug sellers. (msh.org)
- The National Malaria Control Program identified the accredited drug dispensing outlet (ADDO) program as a private sector mechanism to supplement the distribution of subsidized artemisinin-based combination therapies (ACTs) from public facilities and increase access to the first-line antimalarial in rural and underserved areas. (msh.org)
- Having reliable forecasts is critical now for producers, malaria-endemic countries and agencies in order to adapt production and procurement of the artemisinin-based combination treatments (ACTs), the new first-line treatments of malaria. (biomedcentral.com)
- There is no ideal method to quantify drug requirements for malaria. (biomedcentral.com)
- To complement malaria morbidity-based forecasts this study used a consumption approach to produce forecasts of volumes (primarily for drug manufacturers and procurement agencies) and financial requirements (of primary interest for donors and governments). (biomedcentral.com)
- The analysis was limited to first-line drugs in use based on the treatment guidelines at the time of the study, essentially chloroquine and sulphadoxine/pyrimethamine for uncomplicated malaria, and quinine for more severe malaria. (biomedcentral.com)
- They are the frontline drugs in treating human malaria infections. (lstmed.ac.uk)
- Ewing sarcoma tumors disappeared and did not return in more than 70 percent of mice treated with combination therapy that included drugs from a family of experimental agents developed to fight breast cancer, reported St. Jude Children's Research Hospital scientists. (healthcanal.com)
- A clinical trial using the three-drug combination therapy detailed in this research is expected to open later this year for adolescents and young adults with EWS whose tumors have not disappeared with standard therapy or have returned after treatment. (healthcanal.com)
- There is some evidence that this type of defect is present in other pediatric tumors, and we are actively investigating drug sensitivity in those cancers. (healthcanal.com)
- Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a combination of two anti-cancer compounds that shrank pancreatic tumors in mice-supporting the immediate evaluation of the drugs in a clinical trial. (sbpdiscovery.org)
- U.S. Food and Drug Administration (FDA)-approved versions of the compounds are used today to treat certain leukemias and solid tumors, including melanoma. (sbpdiscovery.org)
- The sad reality is that at present, pancreatic cancer therapy is lagging since there is no effective treatment for these tumors," says Ze'ev Ronai, Ph.D. , a professor in Sanford Burnham Prebys' Tumor Initiation and Maintenance Program and senior author of the study. (sbpdiscovery.org)
- Our study identifies a potential treatment combination that can immediately be tested against these aggressive tumors. (sbpdiscovery.org)
- In the study, the scientists used a drug called L-asparaginase to starve pancreatic tumors of a key nutrient, asparagine-an amino acid required for protein synthesis. (sbpdiscovery.org)
- L-asparaginase is FDA approved to treat certain leukemias, and the second drug, a MEK inhibitor, is approved for the treatment of solid tumors, including melanoma, a type of skin cancer. (sbpdiscovery.org)
- However, EGFR-targeted therapies have a significant clinical activity only in a subgroup of cancer patients whose tumors express the EGFR. (eurekaselect.com)
- The study, published in the journal Nature Cell Biology , reports two drugs which are already approved, in another form, for the treatment of leukemia and other solid tumors, including the most aggressive type of skin cancer called melanoma. (news-medical.net)
- The scientists took the patient data from previous studies and used them as the basis for a computational analysis, which showed that this combination was likely to be successful in shrinking a majority of pancreatic tumors. (news-medical.net)
- The experiment showed shrinkage of both melanomas and pancreatic tumors, but the scientists decided to focus first on clinical trials on the latter due to the complete lack of successful therapies at present. (news-medical.net)
- Combination strategies may ultimately require converting non-T cell-inflamed tumors into T cell-inflamed tumors as a means to sensitize tumors to therapies dependent on T-cell killing. (aacrjournals.org)
- Pancreatic tumors recruit a thick layer of connective tissue called stroma that hardens the tumor and acts like a shield," says Olive, whose previous research first uncovered how the stroma makes it difficult for chemotherapy drugs to reach malignant cells. (labmanager.com)
- They also tested PTC596 in combination with gemcitabine and another drug commonly used to treat pancreatic cancer, nab-paclitaxel, using human pancreatic tumors grown in mice. (labmanager.com)
- This combination further enhanced efficacy, making the tumors shrink outright. (labmanager.com)
- Targeted therapy drugs transformed the outlook for people with the rare cancers known as gastrointestinal stromal tumors, enabling some to survive a decade or longer. (ohsu.edu)
- Visualizing how breast tumors grow resistant to drug therapy. (ohsu.edu)
- Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial. (nih.gov)
- This multicentre, randomised trial with 2-year follow-up sought evidence on the efficacy and tolerability of combination therapy (sulphasalazine, methotrexate, hydroxychloroquine, and prednisolone) compared with treatment with a single disease-modifying antirheumatic drug, with or without prednisolone, in the treatment of early rheumatoid arthritis. (nih.gov)
- Combination therapy was better and not more hazardous than single treatment in induction of remission in early rheumatoid arthritis. (nih.gov)
- The combination strategy as an initial therapy seems to increase the efficacy of the treatment in at least a proportion of patients with early rheumatoid arthritis. (nih.gov)
- Combination therapy in rheumatoid arthritis. (nih.gov)
- Objective To compare methotrexate based disease modifying antirheumatic drug (DMARD) treatments for rheumatoid arthritis in patients naive to or with an inadequate response to methotrexate. (bmj.com)
- Design Systematic review and Bayesian random effects network meta-analysis of trials assessing methotrexate used alone or in combination with other conventional synthetic DMARDs, biologic drugs, or tofacitinib in adult patients with rheumatoid arthritis. (bmj.com)
- Objective To determine whether intensive combinations of synthetic disease modifying drugs can achieve similar clinical benefits at lower costs to high cost biologics such as tumour necrosis factor inhibitors in patients with active rheumatoid arthritis resistant to initial methotrexate and other synthetic disease modifying drugs. (bmj.com)
- Participants Patients with rheumatoid arthritis who were eligible for treatment with tumour necrosis factor inhibitors according to current English guidance were randomised to either the tumour necrosis factor inhibitor strategy or the combined disease modifying drug strategy. (bmj.com)
- Delay to institution of therapy and induction of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis. (semanticscholar.org)
- Old drugs, old problems: where do we stand in prediction of rheumatoid arthritis responsiveness to methotrexate and other synthetic DMARDs? (semanticscholar.org)
- LEIDEN, The Netherlands -- For early rheumatoid arthritis, aggressive combination therapy can slow progression to joint damage, investigators here found. (patientcareonline.com)
- Impact of initial aggressive drug treatment with a combination of disease-modifying antirheumatic drugs on the development of work disability in early rheumatoid arthritis: a five-year randomized followup trial. (acponline.org)
- In patients with early rheumatoid arthritis (RA), how does treatment with a combination of disease-modifying antirheumatic drugs (DMARDs) compare with a single DMARD for prevention of work disability? (acponline.org)
- Randomized controlled trial (Finnish Rheumatoid Arthritis Combination Therapy trial). (acponline.org)
- In patients with early rheumatoid arthritis, aggressive initial treatment with a combination of DMARDs reduced the number of days of sick leave and overall work disability at 5 years more than therapy with a single DMARD. (acponline.org)
- The custom BAFF-R antibody is currently being tested as a therapy to treat autoimmune diseases and rheumatoid arthritis in two clinical trials. (thebioconnection.com)
- The program established a supply of subsidized ACTs, created a price system with a cost recovery plan, developed a plan to distribute the subsidized products to the ADDOs, trained dispensers, and strengthened the adverse drug reactions reporting system. (msh.org)
- Importantly, the transition to ACTs has been accomplished in an environment where the safety and efficacy of the drugs and the quality of services are being monitored and regulated. (msh.org)
- This study uses drug consumption to provide elements to help estimate quantities and financial requirements of ACTs. (biomedcentral.com)
- Most current antimalarial drugs are combinations of an artemisinin plus a 'partner' drug from another class, and are known as artemisinin-based combination therapies (ACTs). (lstmed.ac.uk)
- CYP2C19 is a liver enzyme that acts on at least 10% of drugs in current clinical use, most notably the antiplatelet treatment clopidogrel (Plavix) also drugs that treat pain associated with ulcers, such as omeprazole, antiseizure drugs such as mephenytoin, the antimalarial proguanil, and the anxiolytic diazepam. (wikipedia.org)
- Artificial intelligence in drug combination therapy Tsigelny, Igor F 2018-02-09 00:00:00 Abstract Currently, the development of medicines for complex diseases requires the development of combination drug therapies. (deepdyve.com)
- 2018). Combination Drug Therapy for the Management of Low Back Pain and Sciatica: Systematic Review and Meta-Analysis. (eur.nl)
- Combination antihypertensive drug therapy has long been an infrequently exercised therapeutic option in the difficult battle to achieve target blood pressure levels. (aafp.org)
- The many benefits that will accrue from adoption of this therapeutic strategy include improved blood pressure control, fewer drug-induced side effects (including metabolic effects) and lower drug acquisition costs. (aafp.org)
- We believe we are now well positioned to advance our potentially life-changing therapy for adult patients with refractory epilepsy while establishing a strong foundation for future therapeutic opportunities in other uncontrolled neurological conditions. (medindia.net)
- This novel approach helps in elucidating the effects of therapeutic combination on each tumor component and results in unveiling of new anti-cancer mechanisms. (pitchengine.com)
- To enhance therapeutic efﬁcacy and reduce adverse effects of traditional Chinese medicine (TCM), practitioners often prescribe a combination of plant species and/or minerals called formulae. (technologynetworks.com)
- Here, we report that the DGR combination exerts a more robust therapeutic effect than any one or two of the three individual compounds by hitting multiple targets in a rat model of HI. (technologynetworks.com)
- Despite such awareness, the current epi-drug era has opened novel therapeutic avenues for various diseases beyond cancer. (biomedcentral.com)
- Develop in vivo imaging agents (tracers for PET scans) to assess target engagement and the burden of brain pathology to enable successful drug development for existing and new therapeutic targets. (nih.gov)
- After decades in which no novel therapeutic treatments were approved for acute myeloid leukemia (AML), the past few years have seen the approval of several groundbreaking therapies for the disease. (genengnews.com)
- Effective multidrug therapeutic combinations through 4 drugs are described. (ahajournals.org)
- The promising results of this study emphasized the need to test the combinations of epigenetic therapy drugs in clinical trials. (cusabio.com)
- Building on earlier clinical trials, UCLA researchers have confirmed that the "breakthrough" drug palbociclib when used in combination with the traditional hormonal therapy letrozole delays progression of advanced breast cancer significantly and without the harsh side effects seen in some women prescribed letrozole alone. (ucla.edu)
- The study, published online today in the New England Journal of Medicine, is the phase 3 study following phase 1 and phase 2 clinical trials that led to U.S. Food and Drug Administration approval of palbociclib in early 2015. (ucla.edu)
- The results of large clinical trials have led physicians and patients to question the safety of hormone therapy for menopause. (isharonline.org)
- The most recent case involves British company AstraZeneca, which recently started clinical trials for administration of immuno-anticancer drug, "Impinj" in combination with a new drug made in Korea, "Vactosertib. (businesskorea.co.kr)
- MSD is planning to use the drug in clinical trials for gastric and colorectal cancer patients. (businesskorea.co.kr)
- In July, SillaJen joined Regeneron, one of the top five U.S. biopharmaceutical companies, to start on domestic clinical trials for combination therapy for kidney cancer. (businesskorea.co.kr)
- The reason that new drugs developed in Korea receive much attention from global companies is that the competitiveness of these drugs have been proved through various clinical trials. (businesskorea.co.kr)
- Early drug studies demonstrating effective treatments of HbSS and HbSβ 0 thalassaemia, stimulated clinical trials to develop disease-specific therapies to induce fetal haemoglobin due to its ability to block HbS polymerization. (cdc.gov)
- This novel combination approach will be tested in upcoming clinical trials for patients with lung cancer at MD Anderson. (clinicalomics.com)
- Clinical trials have also been conducted to ensure efficacy and safety of these combinations before they are introduced into the market. (georgiasouthern.edu)
- There has also been clinical trials using single and combination drug therapy. (middlebury.edu)
- The challenge is to zero down drugs with molecular targets that restore the healthy state and result in lasting pain relief. (medindia.net)
- The huge advantage of using such a fixed combination is that the active ingredients act on different but distinct molecular targets. (medindia.net)
- Combination therapies are used against complex disorders that have multiple causes along with multiple targets and many small molecule drugs are capable of addressing multiple targets. (pitchengine.com)
- Identification of novel combination-therapy drug targets, which work in synergy to mTOR inhibition using physiological human three-dimensional cancer models. (donau-uni.ac.at)
- Investigative efforts to determine the role of events downstream of deoxy-HbS polymerization, such as endothelial cell activation, cellular adhesion, chronic inflammation, intravascular haemolysis and nitric oxide scavenging, have expanded drug targets which reverse the pathophysiology of SCD. (cdc.gov)
- Our results indicate that all drugs increase phosphorylation of p53, leading to improved induction of p53 targets. (nature.com)
- To maximize the impact of immunotherapy drug development, pretreatment stratification of targets associated with either the T cell-inflamed or noninflamed tumor microenvironment should be employed. (aacrjournals.org)
- Here, we review accumulating knowledge on its working mechanisms and evaluate PP as a novel anti-cancer drug that targets mitochondrial respiration. (frontiersin.org)
- By simultaneously treating the cells with the cancer drug vemurafenib (Zelboraf), which specifically targets faulty BRAF proteins, the researchers were able to determine whether the drug was more effective when the action of other particular proteins was blocked. (ucsf.edu)
- Their hunt began with a drug that targets PI3K, an enzyme that promotes the growth of many cancers, including T-ALL. (divinapharm.eu)
- â When searching for cancer drugs, for example, RNAi may do a better job of approximating precision therapies, both of which only partially inhibit their biological targets,â McManus said. (divinapharm.eu)
- Single (nafcillin for 6 weeks) and combined (nafcillin for 6 weeks plus gentamicin for 2 weeks) drug regimens were compared in two separate multicenter prospective randomized trials. (annals.org)
- Many find the new drug regimens too demanding to take correctly, even though not doing so weakens the benefits of taking the drug. (thebody.com)
- A combination of two drugs, one already approved by the Food and Drug Administration , appears to be effective at shrinking pancreatic cancers in laboratory mice, according to a new study by researchers at the Stanford University School of Medicine . (healthcanal.com)
- Researchers at The University of Texas MD Anderson Cancer Center hope to dramatically improve these statistics with a novel combination therapy, targeting a newly discovered Achilles heel of aggressive and drug resistant cancers. (clinicalomics.com)
- Their study, published today in Science Translational Medicine, reveals how lung cancers with KRAS mutations bypass targeted treatments, and how to thwart their evasion strategy with new drugs. (clinicalomics.com)
- That means therapies for some cancers will have to target more than one mutation at a time to be successful. (ohsu.edu)
- The researchers hope to soon test the drug combination in humans with pancreatic cancer. (healthcanal.com)
- Now researchers have expanded its use to another deadly form of leukemia, drug-resistant T-cell prolymphocytic leukemia ( T-PLL ). (nfcr.org)
- Researchers admit that the initial trial of the cladribine-alemtuzumab combination dealt with a very small number of patients and that larger studies will have to be done per standard medical protocol to confirm safety and efficacy. (nfcr.org)
- A new, pre-clinical study by researchers at Virginia Commonwealth University Massey Cancer Center suggests that a novel drug combination could lead to profound leukemia cell death by disrupting the function of two major pro-survival proteins. (vcu.edu)
- In the study, published in the journal Cancer Research, researchers combined the drug ABT-737 with another agent BEZ235. (vcu.edu)
- In the Phase III CombiRx trial, researchers led by Fred Lublin, MD , of The Mount Sinai Medical Center, sought to determine if Glatiramer Acetate (GA) and Interferon Beta-1a (IFN), the two most commonly-prescribed drugs for relapsing-remitting MS (RRMS), were more effective in combination than as monotherapies. (mountsinai.org)
- In 2013, after women in a clinical study led by UCLA researchers showed a dramatic improvement, the FDA granted palbociclib "breakthrough therapy" status, allowing it to be fast-tracked for approval. (ucla.edu)
- Researchers and clinical staff are very hopeful about this type of combination therapy. (thebody.com)
- Using their mouse disease model, the researchers showed that the combination of these two treatments enhanced killing of acute lymphoblastic leukemia cells-even if the disease was advanced. (thebioconnection.com)
- Using this technique, the researchers eradicated a devastating blood cancer and certain solid tumour cells by jointly administering drugs that are only partially effective when used as single-agent therapies. (divinapharm.eu)
- To find those drugs, the researchers turned to RNA interference (RNAi) â a technique that allows scientists to massively reduce the activity of specific genes. (divinapharm.eu)
- This is especially true, he says, when researchers are seeking to mimic the effects of drugs, which often reduce the activity associated with a particular gene without completely eliminating it. (divinapharm.eu)
- The team of researchers used this combination of antibiotics to destroy the enzymes present in the cell walls of the bacteria. (news-medical.net)
- The combination led to reduced " P . Aeruginosa colony-forming units (CFUs)", the researchers added. (news-medical.net)
- However, Lange was criticised for neglecting the needs of sex workers in the trials, and other researchers asserted that the concerns raised by activists are "entirely legitimate" since the known toxic effects of so-called 'pre-exposure' drugs will lead to liver failure and kidney disease, thereby killing people rather than protecting them. (wikipedia.org)
- Although more evaluation is needed to find out if these combinations would be effective for patients, their activity at low concentrations in the lab is promising, suggesting that they may have clinical activity at levels that are not toxic," said Brennan-Krohn. (bidmc.org)
- They can be as potent and effective as prescription drugs without unwanted side effects. (medindia.net)
- Our findings indicate that a combination of 1% PER and TMP/SMX is an effective alternative therapy for HLI. (aappublications.org)
- A new BJU International study found that combination CC+AZ therapy is safe and effective for patients with elevated estradiol or a low testosterone/estradiol ratio. (medicalxpress.com)
- In the study of 51 men, AZ provided an effective means for lowering estradiol levels and increasing the testosterone/estradiol ratio following the initiation of CC therapy. (medicalxpress.com)
- The combination of drugs in this study may be more effective than ZDV alone. (clinicaltrials.gov)
- The initiation of triple combination therapy, including a protease inhibitor indinavir, during gestation may be the most effective in reducing maternal virus load prior to delivery, thereby potentially benefitting both mother and child. (clinicaltrials.gov)
- A paradigm shift has been observed with respect to the development of effective therapies involving the use of complementary drug combinations. (pitchengine.com)
- Rapid development of medical device and pharmaceutical industry have enabled the development of devices which incorporate drugs into it for effective application. (prsync.com)
- The use of existing drugs for new therapies is advantageous in many respects, such as the knowledge of the effective drug levels and known side effects. (donau-uni.ac.at)
- In addition to the identification of new effective drug combinations we will thereby discover novel pathways, which drive cancer development and will focus on the molecular mechanisms be-hind. (donau-uni.ac.at)
- This study examined the most effective combination methods of CTX and RT against NSCLC. (aacrjournals.org)
- CTx followed by RT was the most effective combination when taxane was administrated. (aacrjournals.org)
- Conclusions: CCRT is the most effective combination when RT is combined with CTx in the NCI-H520 cell line. (aacrjournals.org)
- Palbociclib (marketed as Ibrance by Pfizer) is known as the first new drug that in combination with hormonal therapy has proven to be very effective in post-menopausal women with estrogen receptor-positive breast cancer. (ucla.edu)
- These drug combinations have been more effective than any of the other previously available therapies. (thebody.com)
- As a result, most chemotherapy drugs can't build up to the levels needed to be effective. (labmanager.com)
- For a pancreatic cancer drug to be effective, it needs to stick around long enough to seep past the stroma and accumulate in the tumor. (labmanager.com)
- University of California San Francisco (UCSF) scientists have designed a large-scale screen that efficiently identifies drugs that are potent cancer-killers when combined, but only weakly effective when used alone. (divinapharm.eu)
- The notion that combining targeted therapies is a far more effective way to treat cancer than a single-drug approach has long existed. (divinapharm.eu)
- This combination was tried on mice models with Pseudomonas infections and the results showed that the combination was more effective in killing the bacteria compared to either antibiotic alone. (news-medical.net)
- The study also demonstrates that 'most patients can achieve excellent outcomes when clinicians escalate therapy until the patient achieves a low level of disease activity' and that 'therapy should be individualized because patients with excellent responses were receiving a wide variety of DMARDs and combinations of drugs,' Dr. O'Dell added. (patientcareonline.com)
- Synthetic lethality results from the combination of mutations in two or more genes leading to cell death. (pitchengine.com)
- They found that there were mutations that caused it to be resistant to beta lactam antibiotics like penicillins and cephalosporin group of drugs. (news-medical.net)
- Targeted cancer therapies work by singling out gene mutations that drive tumor growth, then using a drug to block the effects of the mutant gene. (ohsu.edu)
Efficacy and tolerability of combination1
- To minimize the non-specific toxicity of drug combination during cancer therapy, we prepared a new system synthesized from bacteria to deliver the anticancer drugs cytosine arabinoside (Ara-C) and daunorubicin (DNR). (mdpi.com)
- The drugs, which affect the structure and function of the cancer cell's DNA rather than the activity of its proteins, also slowed the growth of human lung cancer cells in mice. (healthcanal.com)
- Mazur and Herner wondered whether tinkering with a cell's epigenetics could control the growth and proliferation of pancreatic cancer cells without causing many of the deleterious side effects seen by drugs that inhibit protein members of the Ras pathway, a cellular signaling cascade that controls cell growth, development and survival. (healthcanal.com)
- Mazur tried eight drugs in combination with JQ1, each targeting either a known cancer-associated pathway or a step involved in epigenetics. (healthcanal.com)
- Approved by the FDA in 1993, the drug cladribine offered hope for the then-fatal blood cancer called hairy cell leukemia, or HCL, and was soon expanded as a therapy for multiple sclerosis. (nfcr.org)
- NUTLEY, N.J., January 07, 2008 /PRNewswire/ -- Data published in this week's New England Journal of Medicine show that oral Xeloda(R) (capecitabine) and oxaliplatin in combination with epirubicin is a comparable alternative to infused fluorouracil (5-FU) and cisplatin with epirubicin in patients with previously untreated, advanced esophagogastric cancer. (drugs.com)
- For example, in cancer therapy, a physician often meets a patient having a genomic profile including more than five molecular aberrations. (deepdyve.com)
- These anti-cancer mechanisms in turn pave the path for development of new drugs and strategies to tackle with the condition. (pitchengine.com)
- The development of potential anti-cancer drugs mostly relies on tissue culture experiments performed on plastic culture dishes, also referred to as two-dimensional culture. (donau-uni.ac.at)
- Adds Rosalie C. Sears, Ph.D. , a professor at Oregon Health & Science University , "It's clear we're not going to find a single magic bullet that cures cancer but will instead need several drugs that target multiple vulnerabilities. (sbpdiscovery.org)
- Stephen Baylin, who is a professor of oncology and medicine from the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, and his team recently found that combinations of epigenetic therapy drugs potentiated anti-tumor responses in human cancer cell lines as well as in mouse models of cancer. (cusabio.com)
- The full paper (Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer) can be read in the journal Cell. (cusabio.com)
- The combination of DNMT inhibitor and HDAC inhibitor appeared to suppress cancer cell proliferation. (cusabio.com)
- According to Professor Baylin, a large proportion of patients with lung cancer failed to respond to immune checkpoint therapy. (cusabio.com)
- Estrogen-receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer subgroup represents the largest proportion of breast cancer cases and is traditionally treated with therapies, like tamoxifen or letrozole, that target the hormone receptor pathway. (ucla.edu)
- The people were treated with a combination of palbociclib and letrozole, and had not received prior systemic therapy for their cancer. (ucla.edu)
- 1. Female patients, age 16 years and older with epithelial ovarian, primary peritoneal or fallopian tube cancer who have relapsed within 12 months of previous platinum-based therapy. (isrctn.com)
- Combined estrogen/progestogen therapy, but not estrogen alone, increases the risk of breast cancer when used for more than three to five years. (isharonline.org)
- Anti-cancer drugs developed in Korea are receiving love calls from global pharmaceutical and biotechnology companies. (businesskorea.co.kr)
- It is a drug that kills cancer cells by enhancing the self-healing ability of the patient. (businesskorea.co.kr)
- The global pharmaceutical company BMS decided to use Pexa-Vec with its self-developed anti-cancer drug "Ipilimumab. (businesskorea.co.kr)
- Preliminary study of the specific endothelin a receptor antagonist zibotentan in combination with docetaxel in patients with metastatic castration-resistant prostate cancer. (icr.ac.uk)
- For patients with metastatic prostate cancer, the 5-year survival rate of 31% points to a need for novel therapies and improvement of existing modalities. (nature.com)
- In vitro experiments reveal that AdRGD-PGp53 sensitizes prostate cancer cells to each of the drugs tested, conferring increased levels of cell death. (nature.com)
- Debruyne F. Hormonal therapy of prostate cancer. (nature.com)
- A new study by scientists at Sanford Burnham Prebys Medical Discovery Institute have discovered a combination of two cancer-fighting drugs that successfully worked on pancreatic tumor in mice, shrinking them significantly, and paving the way for a speedy clinical trial designed to test their efficacy in humans. (news-medical.net)
- ImmunoGen's lead product candidate, the clinical-phase mirvetuximab soravtansine (IMGN853), will be studied with Merck & Co.'s Keytruda ® (pembrolizumab) as a combination therapy for folate receptor alpha (FRα)-positive ovarian cancer. (genengnews.com)
- ImmunoGen said it will add the combination to its ongoing Phase IB/II FORWARD II trial, in which the company is assessing mirvetuximab soravtansine for FRα-positive ovarian cancer in separate combinations with other anticancer agents. (genengnews.com)
- Pyrvinium pamoate (PP) is an FDA-approved classical anthelmintic, but is now attracting particular attention as an anti-cancer drug after recent findings of its potent cytotoxicity against various cancer cell lines only during glucose starvation, as well as its anti-tumor activity against hypovascular pancreatic cancer cells transplanted in mice. (frontiersin.org)
- therefore, a new drug strategy against cancer cells under such tumor microenvironment-mimicking conditions is anticipated. (frontiersin.org)
- In preclinical testing, an experimental drug for pancreatic cancer blocks the formation of microtubules in the cell, hindering growth. (labmanager.com)
- The drug, an experimental compound called PTC596 that had shown antitumor activity in mouse and human pancreatic cancer cells, seemed to have the right qualities: PTC596 has a durable half-life (most cancer drugs have a half-life of a few minutes to hours) and can evade a pump that many cancer cells use to expel drugs. (labmanager.com)
- Based on those studies, Olive, Eberle-Singh, and their collaborators tested PTC596 in combination with gemcitabine (a first-line drug for pancreatic cancer) in genetically engineered mice with an aggressive form of pancreatic cancer that is generally resistant to chemotherapy. (labmanager.com)
- Based on the drug's safety profile and our own findings, there's a good rationale for testing PTC596 in combination with standard therapy in patients with pancreatic cancer," says Olive. (labmanager.com)
- They used mouse models with growing, drug-resistant cancer cells collected from human patients. (thebioconnection.com)
- However, figuring out which drugs can synergise to kill cancer remains a challenge. (divinapharm.eu)
- To demonstrate the power of their screening system, the scientists searched for targeted therapies that could join forces to kill an aggressive blood cancer called T cell acute lymphoblastic leukaemia (T-ALL). (divinapharm.eu)
- We wanted to find drugs that would kill T-ALL when combined with a PI3K inhibitor,â said Roose, a member of the UCSF Helen Diller Family Comprehensive Cancer Center . (divinapharm.eu)
- The study involved following thirty patients who were suffering from the asbestos related cancer, mesothelioma, and eveluating the success of combination drug therapy. (bloggernews.net)
- And most of those who do respond eventually relapse because cancer cells evolve and become resistant to the drugs designed to stop them. (ohsu.edu)
- Gleevec binds to the kinase domain of the mutant enzyme BCR-ABL1 Life expectancy in patients with chronic myeloid leukemia has soared to a level almost equal to that of the general population, according to a Swedish study quantifying the life-saving impact of Gleevec, the targeted therapy ushered from lab bench to clinical success by Brian Druker, M.D., director of the OHSU Knight Cancer Institute. (ohsu.edu)
- ALTERNATIVE CANCER THERAPIES: When does an anecdote become a cure? (healthy.net)
- Cerebral Therapeutics' infusion therapy may offer a more efficacious and reliable approach to treating neurological diseases for which oral and I.V. infused medicines are not able to achieve adequate control and/or are limited by systemic toxicities. (medindia.net)
- However, selection of the most efficacious combinations for each patient can be a daunting task. (deepdyve.com)
- Subsequently, hydroxycarbamide proved efficacious in adults with SCA and was Food and Drug Administration (FDA)-approved in 1998. (cdc.gov)
- Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. (medindia.net)
- Our study showed no significant increase in serious adverse events in the combination therapy," said Stephen Peters, M.D., Ph.D., professor of pulmonary, critical care, allergy and immunologic diseases at Wake Forest Baptist Medical Center and lead author of the study. (wakehealth.edu)
- Ten patients developed adverse reactions, seven receiving active drug and three patients receiving placebo. (arctichealth.org)
- Triple therapy had statistically fewer withdrawals due to adverse events than methotrexate plus infliximab. (bmj.com)
- We conducted a systematic review to investigate the effects of combination drug therapy in patients with low back pain and/or sciatica on pain, disability, and adverse events. (eur.nl)
- These profiles can be assessed both in terms of their expected efficiency in a disease of interest and in terms of potential adverse drug interactions with each other. (biovista.com)
- However, adverse effects still occur with combination therapies. (georgiasouthern.edu)
- People with multiple sclerosis (MS) who were treated with combination therapy did not see significant clinical benefit over those treated with single drug therapy, but combination therapy did reduce the development of new lesions, according to an international research team led by The Mount Sinai Medical Center. (mountsinai.org)
- Our findings suggest that the combination of proteaseinhibitors and other anti-HIV medications can restore the immunesystem to a point where it can fight the CMV retinitis infection onits own," said Dr. Scott Whitcup, clinical director of NEI andfirst author of the JAMA letter. (nih.gov)
- MRI findings also suggested that the IFN plus GA together were better in reducing new lesions and total lesion accumulation than either drug alone. (mountsinai.org)
- The findings may lead to improvements in clinical combination chemotherapy. (nii.ac.jp)
- The therapy will pair the PARP inhibitor olaparib with the chemotherapy drugs irinotecan (IRN) and temozolomide (TMZ). (healthcanal.com)
- The primary outcome showed mean falls in scores on the health assessment questionnaire of −0.30 with the tumour necrosis factor inhibitor strategy and −0.45 with the alternative combined drug strategy. (bmj.com)
- The team also tested the combination of DNMT inhibitor and HDAC inhibitor in mouse models of NSCLC. (cusabio.com)
- Gibbons and colleagues take aim at ZEB1 with a drug called mocetinostat, a histone deacetylase inhibitor previously shown to revert troublesome mesenchymal cells back to well-behaving epithelial cells. (clinicalomics.com)
- The drugs used are L-asparaginase and a MEK inhibitor. (news-medical.net)
- So Pawel had the idea to look for drug combinations that might have a synergistic effect. (healthcanal.com)
- Some of these combination therapy trials show promising preliminary results with synergistic anti-tumour effects in vivo. (donau-uni.ac.at)
- They noted that this combination was synergistic with each other when it came to bacterial killing. (news-medical.net)
- We show a significant 25 per cent reduction in the risk of disease progression with the combination of dabrafenib and trametinib over single-agent dabrafenib," says Assistant Professor Long. (melanoma.org.au)
- Previous studies have shown that aggressive initial drug therapy with a combination of such antirheumatic drugs as methotrexate, hydroxychloroquine, and sulfasalazine in early RA leads to slower progression of joint damage than therapy with a single antirheumatic drug over the first 2 years ( 2 ). (acponline.org)
- The team found that when they used the ceftazidime-avibactam-fosfomycin combination, the progression of the bacteria multiplication was significantly halted. (news-medical.net)
- Some of these pathways [i.e., mammalian target of rapamycin (mTOR), vascular endothelial growth factor receptor (VEGFR), ras/mitogen-activated protein kinase (MAPK) signaling, or insulin like growth factor receptor (IGFR)] which are functionally related to the activity of the EGFR will be discussed in this review to provide a scientific rationale for the combination of drugs which target these pathways with anti-EGFR agents. (eurekaselect.com)
- Our preclinical results suggest Ewing sarcoma is particularly sensitive to this combination therapy, a possible indication that the tumor's DNA repair defect provides us with a much needed advantage to knock out tumor cells," Shelat said. (healthcanal.com)
- The main focus of such therapies is to target all the tumor components and impair their function. (pitchengine.com)
- The scientists then treated mice with a second drug that blocked the stress response pathway and shrank the pancreatic tumor. (sbpdiscovery.org)
- The second drug, the MEK inihibitor, blocks a key enzyme in this pathway, and prevents asparagine synthesis as well as asparagine-dependent protein synthesis in the tumor cells. (news-medical.net)
- We have been pursuing two strategies - combination therapy and repurposing of older antibiotics - to address the challenges posed by Gram-negative infections and, as soon as this pathogen became available for research experiments, we wanted to test whether these strategies would work against the otherwise untreatable Nevada strain. (bidmc.org)
- ATRA-arsenic trioxide was associated with less hematologic toxicity and fewer infections than the chemotherapy combination, but with more hepatic toxi. (everydayhealth.com)
- The goal of this rule-based expert system, with ∼600 rules, was to provide physicians therapy recommendations for patients with bacterial infections . (deepdyve.com)
- The drug combination is very well tolerated and without the side effects of traditional chemotherapy, such as infections, nausea and significant hair loss. (ucla.edu)
- Proceeds from the financing will be used to progress the company's lead program to an investigational new drug (IND) application with the U.S. Food and Drug Administration (FDA) to enable further clinical development. (medindia.net)
- On the contrary, prolonged and tedious development phase followed by high costs of drug development process are some of the factors that might restrain the growth of the market. (pitchengine.com)
- Rising demand for drug combinational devices coupled with research and development initiatives will help the region to grow further at constant rate. (prsync.com)
- Korean company SillaJen is also cooperating with a global company for development of combination therapy. (businesskorea.co.kr)
- The AdRGD-PGp53 approach warrants further development for its application in gene therapy of prostate carcinoma. (nature.com)
- A thorough analysis of Combination Therapy Drug based on the primary market segments, sub-segments, emerging market sectors, Combination Therapy Drug development trends, opportunities and threats to the market development has been evaluated. (dailyhover.com)
- Comprehensive details related to Combination Therapy Drug market development during the forecast period, investment return analysis, technological advancement taking place in Combination Therapy Drug will assist all the market players for planning development strategies. (dailyhover.com)
- This report also covers the Combination Therapy Drug marketing strategies followed by Combination Therapy Drug distributors analysis, potential buyers, marketing channels and Combination Therapy Drug development history. (dailyhover.com)
- Combination Therapy Drug Market analysis based on top players, Combination Therapy Drug market gains, sales, product type, production capacity and gross margin analysis will favor the market development. (dailyhover.com)
- The recommendations focus on a spectrum of basic discovery and translational research activities critical to the development of disease-modifying as well as symptomatic therapies across the disease continuum for the cognitive as well as neuropsychiatric symptoms of Alzheimer's disease, and they identify the types of infrastructures, resources, and new public private partnerships needed to successfully implement this translational agenda. (nih.gov)
- Develop strategies to overcome intellectual property barriers to Alzheimer's disease drug development. (nih.gov)
- There have been several FDA-approved radioimmunoconjugate therapies, including Bexxar, Lutathera, and Azedra, and development of new ARCs is an active area of investigation in the biotechnology and pharmaceutical industries. (genengnews.com)
- 14 Following the completion of single-agent Phase I and Phase II studies, the company has focused clinical development of 225 Ac-lintuzumab in mechanism-based clinical combinations. (genengnews.com)
- Describes investigations to advance the development of potential drug abuse relapse prevention agents by targeting specific receptors of the neurochemical serotonin. (drugabuse.gov)
- After a year, remission was achieved in 24 of 97 patients with combination therapy, and 11 of 98 with single-drug therapy (p=0.011). (nih.gov)
- The combination led to a durable, complete remission in 88 percent of the 16 mice treated. (healthcanal.com)
- The depth of remission achieved with the targeted therapy imatinib (Gleevec) raises a tough new question for some leukemia patients: is it ever safe to stop taking the breakthrough drug developed at OHSU? (ohsu.edu)