Repurposing an old drug to improve the use and safety of tissue plasminogen activator for acute ischemic stroke: minocycline. (1/75)
(+info)Inhaled mannitol in patients with cystic fibrosis: A randomised open-label dose response trial. (2/75)
(+info)PROMISCUOUS: a database for network-based drug-repositioning. (3/75)
(+info)A machine learning-based method to improve docking scoring functions and its application to drug repurposing. (4/75)
(+info)Metformin: its emerging role in oncology. (5/75)
Metformin is considered, in conjunction with lifestyle modification, as a first-line treatment modality for type 2 diabetes mellitus (DM). Recently, several clinical studies have reported reduced incidence of neoplastic diseases in DM type 2 patients treated with metformin, as compared to diet or other antidiabetic agents. Moreover, in vitro studies have disclosed significant antiproliferative and proapoptotic effects of metformin on different types of cancer. Metformin acts by activating AMP-activated protein kinase (AMPK), a key player in the regulation of energy homeostasis. Moreover, by activating AMPK, metformin inhibits the mammalian target of rapamycin complex 1 (mTORC1) resulting in decreased cancer cell proliferation. Concomitantly, metformin induces activation of LKB1 (serine/threonine kinase 11), a tumor suppressor gene, which is required for the phosphorylation and activation of AMPK. These new encouraging experimental data supporting the anti-cancer effects of metformin urgently require further clinical studies in order to establish its use as a synergistic therapy targeting the AMPK/mTOR signaling pathway. (+info)Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases. (6/75)
(+info)Mining significant substructure pairs for interpreting polypharmacology in drug-target network. (7/75)
(+info)Old friends in new guise: repositioning of known drugs with structural bioinformatics. (8/75)
(+info)
Drug repositioning
... (also called drug repurposing) involves the investigation of existing drugs for new therapeutic purposes. ... "Drug repositioning: identifying and developing new uses for existing drugs". Nature Reviews. Drug Discovery. 3 (8): 673-683. ... the disclosure of repositioning online or via publications, and the extent of the novelty of the new drug purpose. Drug ... which effectively strips drug repositioning of its advantages of over de novo drug discovery. Second, the finding of new ...
Sildenafil
"Drug repositioning: identifying and developing new uses for existing drugs". Nature Reviews. Drug Discovery. 3 (8): 673-83. doi ... this decision became an often-cited example of drug repositioning. The drug was patented in 1996, approved for use in erectile ... Institute of Medicine (2014). Drug Repurposing and Repositioning: Workshop Summary. National Academies Press. ISBN ... "Drug Approval Package: Viagra (sildenafil citrate) NDA #020895". U.S. Food and Drug Administration (FDA). 27 March 1998. ...
Repurposing
Drug repositioning (also known as "drug repurposing" or "therapeutic switching") is the application of known drugs and ... "Drug repositioning: identifying and developing new uses for existing drugs". Nature Reviews. Drug Discovery. 3 (8): 673-83. doi ... Institute of Medicine (2014). Drug Repurposing and Repositioning: Workshop Summary. National Academies Press. ISBN ...
Fasoracetam
Drug repositioning FDA/NIH Substance registration system. Page accessed March 21, 2016 "Drug Profile Fasoracetam". "5-oxo-D- ... "Recommended INN List 40" (PDF). WHO Drug Information. 12 (2). 1998. Connolly, J; Glessner, J; Kao, C; Elia, J; Hakonarson, H ( ... Hakonarson's company neuroFix tried to bring the drug to market for this use; neuroFix acquired Nippon Shinyaku's clinical data ... Malykh, AG; Sadaie, MR (12 February 2010). "Piracetam and piracetam-like drugs: from basic science to novel clinical ...
Topical antifungal drugs
Shen, Tao; Huang, Shile (2016). "Repositioning the Old Fungicide Ciclopirox for New Medical Uses". Current Pharmaceutical ... Most antifungal drugs induce fungal cell death by destroying the cell wall of the fungus. These drugs inhibit the production of ... The last group consists of antifungal drugs with a different mechanism of action than the other three classes. These drugs ... The unique components found in fungal cell membranes are usually the drug targets of antifungal drugs, in particular ergosterol ...
S. Joshua Swamidass
A survey of current trends in computational drug repositioning. Briefings in bioinformatics, 17(1), 2-12. Ching, T., ... He has also worked on drug discovery, drug metabolism, and translational research. Swamidass is the founder of "Peaceful ... Swamidass studied drug metabolism, described its impacts in the context of patient morbidity and mortality, and provided new ... 2016). "Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond". PLOS Pathogens ...
Buccal administration
Novel Drug Delivery Technologies: Innovative Strategies for Drug Re-positioning. Singapore: Springer. pp. 29-71. doi:10.1007/ ... As of May 2014, the psychiatric drug asenapine; the opioid drugs buprenorphine, naloxone, and fentanyl; the cardiovascular drug ... Gupta S, Das S, Singh A, Ghosh S (2021-08-15). "A Brief Review on Bucco-adhesive Drug Delivery System". Journal of Drug ... Buccal tablets are also not preferred for drugs that require extended-release. Absorption of drugs via the buccal membrane may ...
Phenotypic screening
Unpredicted Indications for Existing Drugs and Drug Candidates". Drug repositioning: Bringing new life to shelved assets and ... approaches have found more utility in evaluating already approved drugs or late stage drug candidates for drug repositioning. A ... A mechanism unbiased in vivo platform for phenotypic screening and drug repositioning". Drug Discovery Today: Therapeutic ... ". "Therapeutic Drug Repurposing, Repositioning and Rescue Part II: Business Review". Drug Discovery World. 6 April 2015. ...
Tolimidone
Drug Repositioning: Bringing New Life to Shelved Assets and Existing Drugs. John Wiley & Sons. p. 270. ISBN 9781118274392. " ... Drugs missing an ATC code, Drugs with no legal status, Articles containing unverified chemical infoboxes, Bronchodilators, ... Unpredicted Indications for Existing Drugs and Drug Candidates". In Barratt, Michael J.; Frail, Donald E. (eds.). ... After the patent on the compound expired, scientists at the company Melior Discovery identified it as a potential drug ...
PolyAnalyst
Su, Eric Wen; Sanger, Todd M. (23 March 2017). "Systematic drug repositioning through mining adverse event data in ... PolyAnalyst has also been applied to discover new uses for existing drugs by text mining ClinicalTrials.gov and to forecast the ...
Etravirine
March 2019). "Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia". Movement ... In January 2008, the Food and Drug Administration approved its use for patients with established resistance to other drugs, ... Etravine has been studied for use in a drug repositioning application. In a paper published in the medical journal Movement ... "FDA Approves HIV Drug Etravirine". Associated Press. January 18, 2008.[dead link] "First New NNRTI in Nearly a Decade to ...
Nifuroxazide
Bailly C (September 2019). "Toward a repositioning of the antibacterial drug nifuroxazide for cancer treatment". Drug Discovery ... Maurice Claude Ernest Carron patented the drug in the United States in 1966. Subsequent patents issued to Germano Cagliero of ... Drugs with no legal status, Drugboxes which contain changes to verified fields, Drugboxes which contain changes to watched ... fields, Antibiotics, Hydrazides, Phenols, Nitrofurans, All stub articles, Gastrointestinal system drug stubs). ...
Garikapati Narahari Sastry
"Drug repositioning for anti-tuberculosis drugs: An in silico polypharmacology approach". Molecular Diversity. 26 (3): 1675-1695 ... "Drug Discovery Hackathon". www.vigyanprasar.gov.in. Retrieved 2 July 2022. "Indore: Aastha soni selected for Drug Discovery ... computer aided drug design, bucky bowl chemistry, and applications of machine learning in computational drug discovery. He is ... An integrated web portal for drug discovery and drug repurposing". Journal of Biomedical Informatics. 85: 114-125. doi:10.1016/ ...
Christine L. Clouser
The development of new pharmaceuticals takes time and very is costly when compared to drug repositioning: the application of ... These two drugs are FDA approved and used interventionally as chemotherapy drugs. When used together, they have been found to ... Clouser, Christine; Mansky, Louis; Patterson, Steven (July 2010). "Exploiting Drug Repositioning for Discovery of a Novel HIV ... "Drug design success propels efforts to fight HIV with a combination of 2 FDA-approved drugs". ScienceDaily. Retrieved April 25 ...
Phenserine
Hoffer BJ, Pick CG, Hoffer ME, Becker RE, Chiang YH, Greig NH (September 2017). "Repositioning drugs for traumatic brain injury ... Becker RE, Greig NH (November 2010). "Why so few drugs for Alzheimer's disease? Are methods failing drugs?". Current Alzheimer ... Infobox drug articles with non-default infobox title, Articles without KEGG source, Drugs missing an ATC code, Articles ... Its bioavailability was tested by computing the drug's delivery rate across the rat's blood brain barrier. The drug ...
TDR Targets
... and the incorporation of a multilayer network model to guide Drug_repositioning through nice user-friendly visualizations (in ... "A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases". PLOS Neglected Tropical Diseases. 10 (1): ... "Genomic-scale prioritization of drug targets: The TDR Targets database". Nature Reviews Drug Discovery. 7 (11): 900-907. doi: ... the availability of diverse genomic and chemical datasets to facilitate the identification and prioritization of drugs and drug ...
Dental extraction
The flap is repositioned and sutured in place. Anticoagulants are drugs that interfere with the clotting cascade. Antiplatelets ... These drugs are prescribed in certain medical conditions/situations to reduce the risk of a thromboembolic event. With this ... However, whilst these drugs are still used, newer antiplatelet (e.g. ticagrelor) and anticoagulant (e.g. rivaroxaban, apixaban ... "Management of Dental Patients taking Anticoagulant or Anti Platelet Drug" (PDF). Archived (PDF) from the original on 2017-03-28 ...
Friedreich's ataxia
Etravirine, an antiviral drug used to treat HIV, was found in a drug repositioning screening to increase frataxin levels in ... March 2019). "Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia". Movement ... In May 2022, the FDA accepted a new drug application for omaveloxolone and granted it priority review. Omaveloxolone received ... "Reata Pharmaceuticals Announces FDA Approval of Skyclarys (Omavaloxolone), the First and Only Drug Indicated for Patients with ...
Nelfinavir
Shim JS, Liu JO (2014). "Recent advances in drug repositioning for the discovery of new anticancer drugs". International ... Taking the drug with food decreases the risk of diarrhea as a side effect. Nelfinavir is a protease inhibitor: it inhibits HIV- ... It is marketed in Europe by Hoffman-La Roche and elsewhere by ViiV Healthcare.[citation needed] The U.S. Food and Drug ... Nelfinavir belongs to the class of drugs known as protease inhibitors (PIs) and like other PIs is almost always used in ...
Off-target activity
"Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning". Cancers (Basel). 12 (9): 2694. doi ... Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. ...
Power graph analysis
Power graphs have been also applied to the analysis of drug-target-disease networks for drug repositioning. Power graphs have ... "Drug repositioning through incomplete bi-cliques in an integrated drug-target-disease network". Integrative Biology. 4 (7): 778 ...
Personalized onco-genomics
Cheng F, Hong H, Yang S, Wei Y (July 2017). "Individualized network-based drug repositioning infrastructure for precision ... it often develops even more genetic changes that allow it to adapt and survive against the drug. This drug resistance allows ... From the results of her tumour genome sequencing analysis, a drug that is most commonly used in the treatment of type 2 ... Through the understanding of these "drivers" of the cancer growth, appropriate drug choices can be made to target them. Only a ...
Gerardo Turcatti
"Repositioning approved drugs for the treatment of problematic cancers using a screening approach". PLOS ONE. 12 (2): e0171052. ... potency and early detection of off-target effects of potential drugs, they aim to contribute to the acceleration of the drug ... Gerardo Turcatti (born 1959 in Montevideo, Uruguay) is a Swiss-Uruguayan chemist who specialises in chemical biology and drug ... His research also targets the development of efficient methods for drug screening such as highly informative assays. By ...
Wild-type transthyretin amyloid
No drug has been shown to be able to arrest or slow down the process of this condition. There is promise that two drugs, ... Reig, N.; Ventura, S.; Salvadó, M.; Gámez, J.; Insa, R. (2015). "SOM0226, a repositioned compound for the treatment of TTR ... Because of preliminary data suggesting the drug may have activity, the U.S. FDA in 2013 granted tolcapone "orphan drug status" ... "Tolcapone". FDA: Search Orphan Drug Designations and Approvals. 1 January 2013. ...
Tolcapone
"FDA Talk Paper". New Warnings for Parkinson's Drug, Tasmar. Food and Drug Administration. "Tolcapone". FDA: Search Orphan Drug ... Reig N, Ventura S, Salvadó M, Gámez J, Insa R (2015). "SOM0226, a repositioned compound for the treatment of TTR amyloidosis". ... Because of preliminary data suggesting the drug may have activity, the U.S. FDA in 2013 granted tolcapone "orphan drug status" ... Other interactions with this group of drugs have not been studied. A related type of theoretical interactions is with drugs ...
Robot Scientist
"Cheaper faster drug development validated by the repositioning of drugs against neglected tropical diseases". Journal of the ... Robot Scientist Helps Design New Drugs, Voice of America Robot scientist' Eve could speed up search for new drugs, kurzweilai. ... Could Speed Up Drug Discovery, Sky News 'Robot Scientist' Could Speed Up Drug Discovery, Yahoo News "'Robot scientist' Eve ... BBSRC grant A robot scientist for drug design and chemical genetics Archived 24 February 2018 at the Wayback Machine, via ...
Ross D. King
"Cheaper faster drug development validated by the repositioning of drugs against neglected tropical diseases". Journal of the ... King, R. D.; Muggleton, S.; Lewis, R. A.; Sternberg, M. J. (1992). "Drug design by machine learning: The use of inductive logic ... King's research interests are in the automation of science, drug design, AI, machine learning and synthetic biology. He is ... A new Robot Scientist Eve is designed to automate drug discovery. Eve automates high-throughput screening, hit confirmation, ...
Eric R. Gamazon
"Advancing drug repositioning and development for Alzheimer's Disease using functional genomics and computational phenomics". ... "Potential new drugs for Alzheimer's disease identified by researchers". QIMR Berghofer Medical Research Institute, Brisbane, ...
MediGene
The company also started a Phase I/II study of its drug MDG1011 in acute myeloid leukemia and myelodysplastic syndrome. In 2019 ... In 2012-2014, Medigene underwent strategic repositioning through the sale of Eligard, EndoTAG, and RhuDex. The company then ... and received regulatory approval for its cancer drug Eligard in Germany. In 2006, Medigene's product Veregen became the first ...
Gladstone Institutes
... and focuses on drug repositioning; repurposing already-approved drugs for new uses and clinical trials, to speed up (and lower ... "FDA panel backs drug to prevent HIV infection risk". CBS Evening News. Doitsh, Gilad; Cavrois, Marielle; Lassen, Kara G.; ... "Scientists Discover How Key Immune Cells Die During HIV Infection and Identify Potential Drug to Block AIDS". UC San Francisco ... "Drug Approval Package: Truvada (emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg) NDA #021752Orig1s030". www. ...