Drug related side effects and adverse reactions. Medical search

Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.

Immunologically mediated adverse reactions to medicinal substances used legally or illegally.

Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.

Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.

An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.

An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.

Pharmacological agents destructive to nematodes in the superfamily Filarioidea.

Surveillance of drugs, devices, appliances, etc., for efficacy or adverse effects, after they have been released for general sale.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

Any of a variety of eruptive skin disorders characterized by erythema, oozing, vesiculation, and scaling. Etiology is varied.

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*15 allele family.

Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Annual statements reviewing the status of the administrative and operational functions and accomplishments of an institution or organization.

Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.

Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.

Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.

Therapy with two or more separate preparations given for a combined effect.

An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Procedures for the improvement or enhancement of the appearance of the visible parts of the body.

The giving of drugs, chemicals, or other substances by mouth.

Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.

Antisera used to counteract poisoning by animal VENOMS, especially SNAKE VENOMS.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.

A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.

Elements of limited time intervals, contributing to particular results or situations.

The detection of long and short term side effects of conventional and traditional medicines through research, data mining, monitoring, and evaluation of healthcare information obtained from healthcare providers and patients.

A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.

Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.

Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.

A denture replacing one or more (but not all) natural teeth. It is supported and retained by underlying tissue and some or all of the remaining teeth.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

The forcible expulsion of the contents of the STOMACH through the MOUTH.

Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.

Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

The escape of diagnostic or therapeutic material from the vessel into which it is introduced into the surrounding tissue or body cavity.

Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.

A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)

Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.

Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.

Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.

The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.

Bites by snakes. Bite by a venomous snake is characterized by stinging pain at the wound puncture. The venom injected at the site of the bite is capable of producing a deleterious effect on the blood or on the nervous system. (Webster's 3d ed; from Dorland, 27th ed, at snake, venomous)

Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.

Inorganic compounds that contain iodine as an integral part of the molecule.

Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.

The action of a drug that may affect the activity, metabolism, or toxicity of another drug.

Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.

A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)

Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.

The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.

Injections made into a vein for therapeutic or experimental purposes.

Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.

A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.

This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.

An abnormal elevation of body temperature, usually as a result of a pathologic process.

The major of two hallucinogenic components of Teonanacatl, the sacred mushroom of Mexico, the other component being psilocin. (From Merck Index, 11th ed)

An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.

A transient reddening of the face that may be due to fever, certain drugs, exertion, stress, or a disease process.

Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.

A clinical manifestation consisting of an unnatural paleness of the skin.

Spasmodic contraction of the smooth muscle of the bronchi.

A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)

Substances used to allow enhanced visualization of tissues.

Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.

A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.

An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.

An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.

Parasitic infestation of the human lymphatic system by WUCHERERIA BANCROFTI or BRUGIA MALAYI. It is also called lymphatic filariasis.

Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.

Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.

Drugs used to prevent SEIZURES or reduce their severity.

Substances which are of little or no nutritive value, but are used in the processing or storage of foods or animal feed, especially in the developed countries; includes ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS (both plain and LOCAL); VEHICLES; EXCIPIENTS and other similarly used substances. Many of the same substances are PHARMACEUTIC AIDS when added to pharmaceuticals rather than to foods.

Agents that increase uric acid excretion by the kidney (URICOSURIC AGENTS), decrease uric acid production (antihyperuricemics), or alleviate the pain and inflammation of acute attacks of gout.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.

Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.

A plant genus of the family CELASTRACEAE that contains insecticidal sesquiterpenoids and celastrus oil.

A low-osmolar, ionic contrast medium used in various radiographic procedures.

Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.

The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.

Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.

A filarial worm of Southeast Asia, producing filariasis and elephantiasis in various mammals including man. It was formerly included in the genus WUCHERERIA.

Radioactive substances added in minute amounts to the reacting elements or compounds in a chemical process and traced through the process by appropriate detection methods, e.g., Geiger counter. Compounds containing tracers are often said to be tagged or labeled. (Hawley's Condensed Chemical Dictionary, 12th ed)

A range of methods used to reduce pain and anxiety during dental procedures.

An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.

The sudden sensation of being cold. It may be accompanied by SHIVERING.

Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.

Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)

Use of plants or herbs to treat diseases or to alleviate pain.

Abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues. It refers almost exclusively to skin photosensitivity, including sunburn, reactions due to repeated prolonged exposure in the absence of photosensitizing factors, and reactions requiring photosensitizing factors such as photosensitizing agents and certain diseases. With restricted reference to skin tissue, it does not include photosensitivity of the eye to light, as in photophobia or photosensitive epilepsy.

A genus of parasitic nematodes whose organisms live and breed in skin and subcutaneous tissues. Onchocercal microfilariae may also be found in the urine, blood, or sputum.

Drugs used to treat or prevent skin disorders or for the routine care of skin.

A parasitic infection caused by the nematode Loa loa. The vector in the transmission of this infection is the horsefly (Tabanus) or the deerfly or mango fly (Chrysops). The larvae may be seen just beneath the skin or passing through the conjunctiva. Eye lesions are not uncommon. The disease is generally mild and painless.

Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.

Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.

Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).

Substances that reduce the growth or reproduction of BACTERIA.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

Infections by bacteria, general or unspecified.

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.

Vaccines used to prevent infection by viruses in the family ORTHOMYXOVIRIDAE. It includes both killed and attenuated vaccines. The composition of the vaccines is changed each year in response to antigenic shifts and changes in prevalence of influenza virus strains. The vaccine is usually bivalent or trivalent, containing one or two INFLUENZAVIRUS A strains and one INFLUENZAVIRUS B strain.

An antitoxin produced against the toxin of CORYNEBACTERIUM DIPHTHERIAE that is used for the treatment of DIPHTHERIA.

Two or more vaccines in a single dosage form.

Administration of a soluble dosage form by placement under the tongue.

A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.

Substances that reduce or suppress INFLAMMATION.

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.

Skin tests in which the sensitizer is injected.

3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.

A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.

Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

The application of suitable drug dosage forms to the skin for either local or systemic effects.

A dopamine D2 antagonist that is used as an antiemetic.

Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

A clinical syndrome with intermittent abdominal pain characterized by sudden onset and cessation that is commonly seen in infants. It is usually associated with obstruction of the INTESTINES; of the CYSTIC DUCT; or of the URINARY TRACT.

An acute, highly contagious, often fatal infectious disease caused by an orthopoxvirus characterized by a biphasic febrile course and distinctive progressive skin eruptions. Vaccination has succeeded in eradicating smallpox worldwide. (Dorland, 28th ed)

Introduction of substances into the body using a needle and syringe.

Compounds capable of relieving pain without the loss of CONSCIOUSNESS.

Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.

A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).

A genus of parasitic nematodes found throughout the rain-forest areas of the Sudan and the basin of the Congo. L. loa inhabits the subcutaneous tissues, which it traverses freely.

Allergic reaction to peanuts that is triggered by the immune system.

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.

The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.

The practice of compounding and dispensing medicinal preparations.

A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol.

A class of enzymes that catalyzes the ATP-dependent formation of a thioester bond between itself and UBIQUITIN. It then transfers the activated ubiquitin to one of the UBIQUITIN-PROTEIN LIGASES.

A species of parasitic nematode causing Malayan filariasis and having a distribution centering roughly on the Malay peninsula. The life cycle of B. malayi is similar to that of WUCHERERIA BANCROFTI, except that in most areas the principal mosquito vectors belong to the genus Mansonia.

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

Proteins prepared by recombinant DNA technology.

An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

A white threadlike worm which causes elephantiasis, lymphangitis, and chyluria by interfering with the lymphatic circulation. The microfilaria are found in the circulating blood and are carried by mosquitoes.

A republic stretching from the Indian Ocean east to New Guinea, comprising six main islands: Java, Sumatra, Bali, Kalimantan (the Indonesian portion of the island of Borneo), Sulawesi (formerly known as the Celebes) and Irian Jaya (the western part of New Guinea). Its capital is Djakarta. The ethnic groups living there are largely Chinese, Arab, Eurasian, Indian, and Pakistani; 85% of the peoples are of the Islamic faith.

The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically.

A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.

A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.

An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)

Coagulant substances inhibiting the anticoagulant action of heparin.

A family of gram-negative bacteria whose members predominate in the bacterial flora of PLANKTON; FISHES; and SEAWATER. Some members are important pathogens for humans and animals.

Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.

A complex of ferric oxyhydroxide with dextrans of 5000 to 7000 daltons in a viscous solution containing 50 mg/ml of iron. It is supplied as a parenteral preparation and is used as a hematinic. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1292)

A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.

Histiocytic, inflammatory response to a foreign body. It consists of modified macrophages with multinucleated giant cells, in this case foreign-body giant cells (GIANT CELLS, FOREIGN-BODY), usually surrounded by lymphocytes.

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.

Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.

Immunologic techniques involved in diagnosis.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures.

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.

Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)

Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.

An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.

Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.

A republic in the Greater Antilles in the West Indies. Its capital is Port-au-Prince. With the Dominican Republic it forms the island of Hispaniola - Haiti occupying the western third and the Dominican Republic, the eastern two thirds. Haiti belonged to France from 1697 until its rule was challenged by slave insurrections from 1791. It became a republic in 1820. It was virtually an American protectorate from 1915 to 1934. It adopted its present constitution in 1964 and amended it in 1971. The name may represent either of two Caribbean words, haiti, mountain land, or jhaiti, nest. (From Webster's New Geographical Dictionary, 1988, p481 & Room, Brewer's Dictionary of Names, 1992, p225)

A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.

A species of parasitic nematodes widely distributed throughout central Africa and also found in northern South America, southern Mexico, and Guatemala. Its intermediate host and vector is the blackfly or buffalo gnat.

Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)

Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.

A synthetic tetracycline derivative with similar antimicrobial activity.

Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.

A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.

The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.

The presence of organisms, or any foreign material that makes a drug preparation impure.

A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)

The instillation or other administration of drugs into the bladder, usually to treat local disease, including neoplasms.

Vaccine used to prevent YELLOW FEVER. It consists of a live attenuated 17D strain of the YELLOW FEVER VIRUS.

The individuals employed by the hospital.

A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.

Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.

Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.

Skin diseases caused by bacteria, fungi, parasites, or viruses.

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (1/2245)

A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to the drug or a metabolic aberation of the host permitting the accumulation of hepatotoxic metabolites. The syndromes of hepatic disease produced by drugs have been classified hepatocellular, hepatocanalicular, mixed and canalicular. Measurement of serum enzyme activities has provided a powerful tool for studies of hepatotoxicity. Their measurement requires awareness of relative specificity, knowledge of the mechanisms involved, and knowledge of the relationship between known hepatotoxic states and elevated enzyme activities. (+info)

Use of ineffective or unsafe medications among members of a Medicare HMO compared to individuals in a Medicare fee-for-service program. (2/2245)

Adverse drug reactions and inappropriate prescribing practices are an important cause of hospitalization, morbidity, and mortality in the elderly. This study compares prescribing practices within a Medicare risk contract health maintenance organization (HMO) in 1993 and 1994 with prescribing practices for two nationally representative samples of elderly individuals predominantly receiving medical care within the Medicare fee-for-service sector. Information on prescriptions in the fee-for-service sector came from the 1987 National Medical Expenditures Survey (NMES) and the 1992 Medicare Current Beneficiary Survey (MCBS). A total of 20 drugs were studied; these drugs were deemed inappropriate for the elderly because their risk of causing adverse events exceeded their health benefits, according to a consensus panel of experts in geriatrics and pharmacology. One or more of the 20 potentially inappropriate drugs was prescribed to 11.53% of the Medicare HMO members in 1994. These medications were prescribed significantly less often to HMO members in 1994 than to individuals in the fee-for-service sector, based on information from both the 1987 NMES and the 1992 MCBS. Utilization of unsafe or ineffective medications actually decreased with increasing age in the HMO sample, with lowest rates in individuals over the age of 85. However, no relationship between age and medication use was seen in the NMES study, except for individuals over the age of 90 years. The study data support the conclusion that ineffective or unsafe medications were prescribed less often in the Medicare HMO than in national comparison groups. In fact, for the very old, who are most at risk, the use of these medications was much lower in the Medicare HMO than in the Medicare fee-for-service sector. Nevertheless, in 1994, approximately one of every nine members of this Medicare HMO received at least one such medication. Continued efforts and innovative strategies to further reduce the use of unsafe and ineffective drugs among elderly Medicare HMO members are needed. (+info)

Is reporting rate a good predictor of risks associated with drugs? (3/2245)

AIMS: Uncertainty as to relative under-reporting plagues the comparisons of spontaneous reporting rates as a tool for decision-making in pharmacovigilance. However, it is generally accepted that under-reporting should be reasonably similar for similar drugs sharing the same indication, country and period of marketing. To test this, we compared the adverse drug reaction reporting rates to the French regional pharmacovigilance centres for six pairs of identical drug marketed at the same time by different companies under different brand names (co-marketing). METHODS: All reaction reports were related to sales, to compute reporting rate; within each pair, the reporting rate ratio and its confidence interval were calculated. RESULTS: The rate ratios were all between 0.76 and 1.33. Two of them were significantly different from 1 (1.28; 95% C.I. [1.01; 1.60] and 1.33; 95% C.I. [1.06; 1.74]). CONCLUSIONS: These small differences in reporting rates would not warrant regulatory action and support the usual assumption of similar reporting for similar drugs. (+info)

Retrospective analysis of the frequency and recognition of adverse drug reactions by means of automatically recorded laboratory signals. (4/2245)

AIMS: To estimate the frequency of adverse drug reactions (ADRs) identified through the use of automatic signals generated from laboratory data (ALS) in hospitalised patients. To determine the frequency of spontaneous recognition of these ADRs by the attending physicians and to assess the potential value of ALS for detection of ADRs. METHODS: Laboratory results of patients hospitalised in a nine bed medical ward were automatically recorded over a period of 17 months. Values exceeding defined boundaries were used as ALS. Charts of every third patient were analysed retrospectively with regard to adverse drug related reactions and causality was evaluated as well as whether the ADR had been recognised during the period of hospitalisation. RESULTS: The charts and ALS of 98 patients were analysed. In 18 cases a drug-related adverse reaction was probable. Awareness to the reaction by the treating physicians was evident in 6 out of these 18 ADRs. Approximately 80% of the ADRs were considered predictable. Three ADRs were regarded as serious. CONCLUSIONS: Adverse drug reactions are common and often preventable. Only one third of ADRs which could have been detected through ALS were recognised by the attending physicians. An increased doctor's awareness of the frequency of drug related abnormal laboratory results by means of ALS is likely to increase the recognition rate of ADRs and might help to prevent them. (+info)

Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke. (5/2245)

AIMS: To estimate the incidence of newly diagnosed idiopathic stroke among users of fenfluramine, dexfenfluramine and phentermine compared to obese nonusers. METHODS: We conducted a cohort study with nested case-control analysis utilizing data from the General Practice Research Database in the UK. Eight thousand four hundred and twenty-three subjects aged 69 years or less at the start of follow-up were exposed to at least one of the three study drugs and 17 225 similarly obese subjects were not exposed to any of the study drugs. RESULTS: We identified 45 incident cases of idiopathic CVA in this cohort of subjects. The incidence of CVA among all current users of a diet drug was 1.3/1000 person-years (95% CI 0.5, 3.5). The incidence for current fenfluramine users (n=2) was 2.6/1000 person-years (95% CI 0.7, 9.6), for current dexfenfluramine users (n=1) 1.1/1000 person-years (95% CI 0.3, 3.8), and for current phentermine users 0/1000 person-years (95% CI 0.0, 12.9). The incidence in obese nonusers was 0.6/1000 person-years (95% CI 0.4, 0. 9). The adjusted matched odds ratio (OR) for thrombotic stroke from the case-control analysis comparing current use of a diet drug to nonuse was 2.4 (95% CI 0.6, 9.1). There was only one exposed subject among seven who had haemorrhagic stroke. CONCLUSIONS: The incidence of CVA in generally young obese subjects during use of fenfluramine, dexfenfluramine or phentermine is low. Although we found an OR of 2. 4 comparing users of any of the anorexiants with nonusers, this is based on only three exposed cases and the confidence limits are wide. We conclude that our study does not support a substantial increased risk of stroke attributable to the use of fenfluramine, dexfenfluramine or phentermine. (+info)

Agranulocytosis in Bangkok, Thailand: a predominantly drug-induced disease with an unusually low incidence. Aplastic Anemia Study Group. (6/2245)

Agranulocytosis, a syndrome characterized by a marked reduction in circulating granulocytes, is strongly associated with medical drug use in Europe and the United States. Unregulated use of common pharmaceutical agents in developing countries has been suspected of causing large numbers of cases of agranulocytosis and deaths, especially among children. To elucidate the incidence and etiology of agranulocytosis in Thailand, a population-based case-control study of symptomatic agranulocytosis that resulted in hospital admission was conducted in Bangkok from 1990 to 1994. An attempt was also made to study the disease in Khonkaen (in northeastern Thailand) and Songkla (in southern Thailand), but there were insufficient cases in the latter regions, and the analysis was confined to subjects from Bangkok. In that region, the overall incidence of agranulocytosis was 0.8 per million per year; there were no deaths. As expected, the incidence was higher in females (0.9 per million), and it increased with age (4.3 per million beyond age 60). Among 25 cases and 529 controls the relative risk estimate for a combined category of all suspect drugs was 9.2 (95% confidence interval = 3.9-21), and the proportion of cases that could be attributed to drug use was 68%. For individual drugs and drug classes the data were sparse; within these limitations, the strongest association appeared to be with antithyroid drugs. One case and three controls were exposed to dipyrone, a drug known to cause agranulocytosis; with such scanty data the risk could not be evaluated. Exposure to pesticides or solvents was not associated with an increased risk. This is the first formal epidemiologic study of agranulocytosis in a developing country. As in the West, most cases are attributable to medical drug use. However, the incidence of agranulocytosis in Bangkok, and apparently, in Thailand as a whole, is unusually low, and the disease does not pose a public health risk. (+info)

The lung in the immunocompromised patient. Infectious complications part 2. (7/2245)

Pulmonary infections decisively contribute to morbidity and mortality in immunocompromised patients. Bacterial, mycobacterial and infections with Pneumocystis carinii have been reviewed in an article in the last issue of Respiration. In this review, viral and fungal pulmonary infections are discussed in HIV-positive patients and in patients treated with high-dose chemotherapy, stem cell or solid-organ transplantation. (+info)

A prospective study of adverse drug reactions in hospitalized children. (8/2245)

AIMS: There are few publications of adverse drug reactions (ADRs) among paediatric patients, though ADR incidence is usually stated to be higher during the first year of life and in male patients. We have carried out a prospective study to assess the extent, pattern and profile risk for ADRs in hospitalized patients between 1 and 24 months of age. METHODS: An intensive events monitoring scheme was used. A total of 512 successive admissions to two medical paediatric wards (47 beds) were analysed. The hospital records were screened daily during two periods (summer, 105 days and winter, 99 days), and adverse clinical events observed were recorded. RESULTS: A total of 282 events were detected; of these, 112 were considered to be manifestations of ADRs. The cumulative incidence was 16.6%, no differences being observed between periods. Although there were no differences between patients under and over 12 months of age, risk was found to be significantly higher among girls compared with boys (RR=1.66, 95% CI 1.03-2.52). The gastro-intestinal system was most frequently affected. The therapeutic group most commonly implicated was anti-infective drugs and vaccines (41.5%). The ADRs were mild or moderate in over 90% of cases. A consistent relationship was noted between the number of drugs administered and the incidence of ADRs. CONCLUSIONS: Hospitalized patients exhibited an ADR risk profile that included female sex and the number of drugs administered. No particular age predisposition was observed. The most commonly prescribed drugs are those most often implicated in ADRs in paediatric patients. (+info)

Adverse Drug Reactions Advisory Committee (February 2004). "Australian Adverse Drug Reactions Bulletin, Volume 23, Number 1". ... The most common adverse reactions are related to the liver with 32 reports. Other more commonly reported reactions include ... Aronson JK (21 February 2009). Meyler's Side Effects of Endocrine and Metabolic Drugs. Elsevier. pp. 150-152. ISBN 978-0-08- ... Chitturi, Shivakumar; Farrell, Geoffrey C (2013). "Adverse Effects of Hormones and Hormone Antagonists on the Liver". Drug- ...

https://en.wikipedia.org/wiki/Side_effects_of_cyproterone_acetate

... are drugs used to kill bacteria; they can have side effects or even cause adverse reactions in people, however they are not ... "Effect of pH on Growth Rate". Brooklyn College. Retrieved October 8, 2016. Wikimedia Commons has media related to Bacterial ... Related devices include turbidostats and auxostats. When Escherichia coli is growing very slowly with a doubling time of 16 ... "Effect of endogenous carotenoids on "adaptive" mutation in Escherichia coli FC40". Mutat. Res. 473 (1): 109-19. doi:10.1016/ ...

https://en.wikipedia.org/wiki/Bacterial_growth

... to work out which genetic factors contribute to our chances of becoming unwell or of suffering from drug-related side-effects. ... Adverse reactions to prescription drugs delay recovery and drain healthcare resources. Generation Scotland is therefore ... Kongkaew C, Noyce PR, Ashcroft DM (July 2008). "Hospital admissions associated with adverse drug reactions: a systematic review ... Disease risk and drug response are examples of complex traits. Instead of having a single cause, complex traits typically ...

https://en.wikipedia.org/wiki/Generation_Scotland

All of the opioids can cause side effects. Common adverse reactions in patients taking opioids for pain relief include nausea ... Due to severe side effects such as tardive dyskinesia, haloperidol is now rarely used. A related drug, prochlorperazine is more ... Candiotti KA, Gitlin MC (July 2010). "Review of the effect of opioid-related side effects on the undertreatment of moderate to ... Opioid side effects (Vimeo) (YouTube)-A short educational film about the practical management of opioid side effects. (Articles ...

https://en.wikipedia.org/wiki/Opioid

The side effects were less severe in the high- dose treatment group and thus were not related to the dosage of VIR- 576. In ... VIR-576 was well tolerated and did not cause major adverse effects.[citation needed] Retrovirus HIV Antiretroviral drug Fusion ... This fact allows the union of the subunits during the reaction with the gp41 and also allows them to act simultaneously. Thanks ... and most of them didn't show secondary effects. Generally, the effects were temporal and tolerable like constipation, headaches ...

https://en.wikipedia.org/wiki/VIR-576

Evans WE, McLeod HL (February 2003). "Pharmacogenomics--drug disposition, drug targets, and side effects". The New England ... In 2012, McKinsey & Company concluded that the cost of the 50-100 million preventable error-related adverse drug events would ... Pathogenesis of adverse drug reactions. In: Davies DM, ed. Textbook of adverse drug reactions. Oxford: Oxford University Press ... of patients had an adverse drug reaction to at least one drug, and pharmacist involvement helps to pick up adverse drug ...

https://en.wikipedia.org/wiki/Adverse_drug_reaction

Studies suggest that loperamide is more effective and has lower neural side effects. Adverse drug reactions most commonly ... Florey K (1991). Profiles of Drug Substances, Excipients and Related Methodology, Volume 19. Academic Press. p. 342. ISBN ... "Drugs@FDA: FDA Approved Drug Products". U.S. Food and Drug Administration (FDA). Archived from the original on 6 May 2016. ... "Drugs@FDA: FDA Approved Drug Products". U.S. Food and Drug Administration (FDA). Archived from the original on 6 May 2016. ...

https://en.wikipedia.org/wiki/Loperamide

Bogdan Kirilov, the executive director of the Bulgarian Drug Agency, noted that all of the serious adverse reactions in the ... According to a Ministry of Health report from October 2021, side effects are more frequent after the second dose in the case of ... Media related to COVID-19 vaccination in Bulgaria at Wikimedia Commons National Vaccination Plan against COVID-19 for the ... but no serious adverse effects were reported until 12 March. Bogdan Kirilov, the executive director of the Bulgarian Drug ...

https://en.wikipedia.org/wiki/COVID-19_vaccination_in_Bulgaria

Examples of drug responses include adverse drug reactions, changes in drug efficacy and alterations in how quickly or slowly a ... drugs, phenotypes (including diseases and side effects) and PubMed IDs (PMIDs). Variant annotations are summaries describing ... PharmGKB has many different types of PGx-related information available through the website, discussed in the sections below. ... EMA-approved drug labels (known as European Public Assessment Reports (EPARs)) are manually searched for using the drugs in the ...

https://en.wikipedia.org/wiki/PharmGKB

Other side effects include allergic reactions. It is in the calcitonin gene-related peptide antagonist class of medications. It ... The most common adverse effects are reactions at the injection site, which occurred in 43 to 45% of people in studies (as ... "AJOVY prescribing information" (PDF). Drugs@FDA: FDA-Approved Drugs. Retrieved 11 July 2020. "Fremanezumab". Drug Information ... The most common side effect is pain and redness at the site of injection. ...

https://en.wikipedia.org/wiki/Fremanezumab

When taken by mouth, Echinacea does not usually cause side effects, but may have undesirable interactions with various drugs ... and that it may have adverse reactions with other medications. One of the most extensive and systematic studies to review the ... "gastrointestinal and skin-related." Such side effects include nausea, abdominal pain, diarrhea, itch, and rash. Echinacea has ... Some therapists have claimed that echinacea can help relieve side effects from cancer treatments such as chemotherapy and ...

https://en.wikipedia.org/wiki/Echinacea

... and rated the adverse effects of these drugs lower than non-users, showing more confidence in the result of these drugs. In a ... Although there were no reported side effects from DBS, 18% of the patients reported device-related complications such as ... In the drug trials, participants reported the following adverse reactions to the consumption of donepezil, memantine, MPH, or ... Neuroenhancement drugs need to be assessed further for their merits and adverse effects, making it easier for policy makers to ...

https://en.wikipedia.org/wiki/Neuroenhancement

Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced ... Most people develop side effects. Common side effects include low white blood cell counts, loss of appetite, vomiting, hair ... Other severe side effects include an increased future risk of cancer, infertility, allergic reactions, and pulmonary fibrosis. ... increasing both pharmacologic and toxic effects of the drug; alternatively, drugs that inhibit hepatic microsomal enzymes (e.g ...

https://en.wikipedia.org/wiki/Cyclophosphamide

Adverse reaction An unwanted effect caused by the administration of drugs. Onset may be sudden or develop over time (NLM) ... ICH E6) Adverse effect An unwanted side effect of treatment. (NCI) Adverse event An unexpected medical problem that happens ... all noxious and unintended responses to a medicinal product related to any dose should be considered adverse drug reactions. ... NCI) Drug-drug interaction A modification of the effect of a drug when administered with another drug. The effect may be an ...

https://en.wikipedia.org/wiki/Glossary_of_clinical_research

Common side effects of NSAIDs include stomach ulcers headaches, drowsiness allergic reactions. Rarer side effects consist of ... "Rheumatoid Arthritis Drug Guide: Types of Drugs, Uses, Side Effects". WebMD. Retrieved 2021-04-01. "2019 American College of ... Other adverse effects include: Life-threatening Interstitial lung disease Tubular necrosis Renal failure Skin reactions ... Methotrexate is commonly associated with dose-related toxic effects involving the bone marrow and gastrointestinal tract. Folic ...

https://en.wikipedia.org/wiki/Antiarthritics

... might show adverse drug reactions (ADRs) characteristic of the sulfa related drugs. Silodosin shows high affinity and ... Today phenoxybenzamine is not the first choice due to many side effects like lowering blood pressure. First selective alpha-1 ... Carruthers, S. G. (July 1994). "Adverse effects of alpha 1-adrenergic blocking drugs". Drug Safety. 11 (1): 12-20. doi:10.2165/ ... since the adverse effects of Prazosin are dose-related. This is also the case for Tamsulosin and it may be assumed that the ...

https://en.wikipedia.org/wiki/Alpha-1_blocker

The most common side effects include infections, hypertension, infusion-related reactions, and pyrexia. The U.S. Food and Drug ... infusion reactions (27%), and fever (24%). Serious adverse effects occurred in about half of the subjects studied in the ... In the clinical trials that lead to emapalumab's FDA approval, the most commonly reported adverse effects were infections (56 ... "Emapalumab Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). 26 March 2010. Retrieved 19 March ...

https://en.wikipedia.org/wiki/Emapalumab

... careful extraction gives an acceptable frequency of adverse reactions, which are largely related to the gastrointestinal tract ... a drug safety bulletin advising consumers not to use medicines containing lei gong teng due to potentially serious side effects ... It has immunomodulatory effects. At medicinal doses, T. wilfordii extract can have significant side effects, including ... A 2016 review found gastrointestinal symptoms in 13%, adverse reproductive outcomes in 12%, adverse skin reactions in 8%, ...

https://en.wikipedia.org/wiki/Tripterygium_wilfordii

... the side effects of medications, poor sleeping habits or recreational drug use, making misdiagnosis likely.[citation needed] ... In late 2007 an alert for severe adverse skin reactions to modafinil was issued by the FDA. Pemoline was previously used but ... Additional related medications include mazindol and selegiline. Another FDA-approved treatment option for narcolepsy is sodium ... Potential side effects of medication can also be addressed. Regular follow-up is useful to be able to monitor the response to ...

https://en.wikipedia.org/wiki/Narcolepsy

... mechanism of estramustine-related adverse reactions?". Int. J. Urol. 16 (10): 836-41. doi:10.1111/j.1442-2042.2009.02374.x. ... The side effects of EMP overall have been described as relatively severe. The most common side effects of EMP have been ... 114-. ISBN 978-94-011-4439-1. "Drugs@FDA: FDA Approved Drug Products". United States Food and Drug Administration. Retrieved 29 ... These side effects are due to high estrogen levels and low testosterone levels. Prophylactic irradiation of the breasts can be ...

https://en.wikipedia.org/wiki/Estramustine_phosphate

Side Effects and Drug Images at RxList". RxList. Chua AL, Silberstein S (September 2016). "Inhaled drug therapy development for ... Research from the Veterans Administration and United States Food and Drug Administration show injection site reactions. Adverse ... Richelson E, Pfenning M (September 1984). "Blockade by antidepressants and related compounds of biogenic amine uptake into rat ... Common side effects include sleepiness, blurry vision, low blood pressure, and dizziness. Serious side effects may include ...

https://en.wikipedia.org/wiki/Prochlorperazine

... may be associated with adverse effects as second primary malignancy, severe cutaneous reactions, hypersensitivity ... Common side effects include diarrhea, itchiness, joint pain, fever, headache, and trouble sleeping. Severe side effects include ... In March 2008, the U.S. Food and Drug Administration (FDA) included lenalidomide on a list of twenty prescription drugs under ... reactions, tumor lysis syndrome, tumor flare reaction, hypothyroidism, and hyperthyroidism. Lenalidomide is related to ...

https://en.wikipedia.org/wiki/Lenalidomide

Adverse effects of psychoactive drugs, Antipsychotics, Mental disorders screening and assessment tools, University of Liverpool ... parkinsonian type side effects. Autonomic - related to uncontrollable side effects. Psychic - relating to the functioning of ... known side effects without category. Anticholinergic - side-effects impacting the choline system. Allergic reaction. Prolactin ... This psychiatric assessment tools allows for the monitoring of side effects related to neuroleptic (or anti-psychotic) ...

https://en.wikipedia.org/wiki/Liverpool_University_Neuroleptic_Side-Effect_Rating_Scale

Psychiatry maintain that psychiatrists exaggerate the evidence of medication and minimize the evidence of adverse drug reaction ... book by author Robert Whitaker List of long term side effects of antipsychotics "The antipsychiatry movement: Who and why". ... This has not been shown to be directly related to the therapeutic use of stimulants, but to neuroleptics. The diagnosis of ... partly due to serious adverse effects such as tardive dyskinesia, and partly due their "chemical straitjacket" effect and their ...

https://en.wikipedia.org/wiki/Anti-psychiatry

... side effects include insulin resistance, hyperglycemia and lipodystrophy. Nelfinavir can produce a range of adverse side ... Taking the drug with food decreases the risk of diarrhea as a side effect. Nelfinavir is a protease inhibitor: it inhibits HIV- ... Nelfinavir and these related molecules did not exhibit detectable antibiotic activity, but did also inhibit the production of ... or allergic reactions may occur, but are rare (less than one in one thousand patients) . Nelfinavir inhibits maturation and ...

https://en.wikipedia.org/wiki/Nelfinavir

... and prior knowledge of the severe adverse side effects for geriatric patients, including deep vein thrombosis, toxic reactions ... Pharmacology of the Endocrine System and Related Drugs: Progesterone, Progestational Drugs and Antifertility Agents. Vol. II. ... The most common side effect of MGA is weight gain, with an incidence of 15 to 70% at the high dosages used to treat breast ... This is based on the fact that no virilizing side effects have been observed with the use of MGA in patients of either sex at ...

https://en.wikipedia.org/wiki/Megestrol_acetate

To avoid side effects, it is recommended for patients with chronic kidney failure or cancer to use the lowest possible dose ... Other reported adverse reactions include increased risk of seizure, hypotension, and chest pain.[citation needed] Darbepoetin ... Amgen advised the U.S. Food and Drug Administration (FDA) as to the results of the DAHANCA 10 clinical trial. The DAHANCA 10 ... A recent study has extended these findings to treatment of patients exhibiting cancer-related anemia (distinct from anemia ...

https://en.wikipedia.org/wiki/Darbepoetin_alfa

The main adverse drug reactions (ADRs) associated with NSAID use relate to direct and indirect irritation of the ... Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of ... These hypersensitivity reactions differ from the other adverse reactions listed here which are toxicity reactions, i.e. ... are dose-related, and can occur in any treated individual; hypersensitivity reactions are idiosyncratic reactions to a drug. ...

https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug

Adverse effects are mainly related to its antimuscarinic effects. Common adverse drug reactions (≥1% of people) include: dry ... Common side effects include a dry mouth, runny nose, upper respiratory tract infection, shortness of breath and headache. ... Severe side effects may include angioedema, worsening bronchospasm, and QT prolongation. Tentative evidence has not found harm ...

https://en.wikipedia.org/wiki/Tiotropium_bromide

Aronson JK (4 March 2014). Side Effects of Drugs Annual: A worldwide yearly survey of new data in adverse drug reactions. ... Other side effects that have been observed in men and that are similarly related to androgen deprivation include hot flashes, ... This could, in turn, result in increased free concentrations of such drugs and increased effects and/or side effects, ... Common side effects in men include breast enlargement, breast tenderness, and hot flashes. Other side effects in men include ...

https://en.wikipedia.org/wiki/Bicalutamide

... base and has traditionally been discouraged for reasons that include concerns about such potential adverse drug effects as ... Quazepam has fewer side effects than other benzodiazepines and less potential to induce tolerance and rebound effects. There is ... Quazepam is used for short-term treatment of insomnia related to sleep induction or sleep maintenance problems and has ... and withdrawal reactions consistently across all the medicines in the class. Tolerance may occur to quazepam but more slowly ...

https://en.wikipedia.org/wiki/Quazepam

... receptor which in turn enhances the effect of the GABAA receptor producing its therapeutic effects as well as adverse effects. ... and residual effects. Some side effects, including drowsiness, amnesia, and respiratory depression, are increased when ... Physical dependence occurs due to physiological adaptations occurring as the body attempts to overcome the drugs effects which ... The dependence induced by lormetazepam is related to changes in the sensitivity of the GABA-BZD receptor complex. Withdrawal ...

https://en.wikipedia.org/wiki/Lormetazepam

"A surveillance method for the early identification of idiosyncratic adverse drug reactions". Drug Saf. 31 (2): 169-80. doi: ... Side effects of pemoline include insomnia, decreased appetite, abdominal pain, irritability, and headaches. It has minimal ... Pemoline has been studied in and reported to be effective in the treatment of fatigue due to multiple sclerosis and HIV-related ... However the reactions proved idiosyncratic and unpredictable, with patients sometimes taking the drug with no issue for months ...

https://en.wikipedia.org/wiki/Pemoline

The majority of adverse reactions to the 17D vaccine result from allergic reaction to the eggs in which the vaccine is grown. ... Mild side effects may include headache, muscle pains, pain at the injection site, fever, and rash. Severe allergies occur in ... "YF-Vax". U.S. Food and Drug Administration (FDA). 6 August 2019. Retrieved 28 December 2019. World Health Organization (July ... In no case of vaccine-related illness has there been evidence of the virus reverting to a virulent phenotype.[medical citation ...

https://en.wikipedia.org/wiki/Yellow_fever_vaccine

People have had severe infusion-related reactions to pembrolizumab. There have also been severe immune-related adverse effects ... kidney inflammation due to the drug. The common adverse reactions have been fatigue (24%), rash (19%), itchiness (pruritus) (17 ... Common side effects include fatigue, musculoskeletal pain, decreased appetite, itchy skin (pruritus), diarrhea, nausea, rash, ... they may be used after pembrolizumab is started to deal with immune-related adverse effects. Women of child-bearing age should ...

https://en.wikipedia.org/wiki/Pembrolizumab

Hypothyroidism~treatment at eMedicine "Synthroid (Levothyroxine Sodium) Drug Information: Uses, Side Effects, Drug Interactions ... Allergic reactions to the drug are characterized by symptoms such as difficulty breathing, shortness of breath, or swelling of ... The related drug dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia (elevated ... Certain other substances can cause adverse effects that may be severe. Combination of levothyroxine with ketamine may cause ...

https://en.wikipedia.org/wiki/Levothyroxine

Wikimedia Commons has media related to Herbalism. Aronson JK (2008). Meyler's Side Effects of Herbal Medicines. Elsevier. ISBN ... or lack of understanding of plant and drug interactions have led to adverse reactions that are sometimes life threatening or ... Although not frequent, adverse reactions have been reported for herbs in widespread use. On occasion serious untoward outcomes ... Plants have chemical defense mechanisms against predators that can have adverse or lethal effects on humans. Examples of highly ...

https://en.wikipedia.org/wiki/Herbal_medicine

... of adults after three doses with only mild or moderate and transient adverse effects. On 21 December 1998, the Food and Drug ... Subsequently, hundreds of vaccine recipients reported they had developed autoimmune and other side effects. Supported by some ... The Lyme-related Borrelia species are collectively known as Borrelia burgdorferi sensu lato, and show a great deal of genetic ... Polymerase chain reaction (PCR) tests for Lyme disease have also been developed to detect the genetic material (DNA) of the ...

https://en.wikipedia.org/wiki/Lyme_disease

... may be at an increased risk for adverse effects of doxepin due to their slower clearance of the drug. Another study assessed ... Common side effects include sleepiness, dry mouth, constipation, nausea, and blurry vision. Serious side effects may include ... Media related to Doxepin at Wikimedia Commons "Doxepin". Drug Information Portal. U.S. National Library of Medicine. "Doxepin ... Co-treatment with thyroid hormones may also increase the potential for adverse reactions. Doxepin is a tricyclic antidepressant ...

https://en.wikipedia.org/wiki/Doxepin

Aronson, Jeffrey K. (2015). Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and ... The GACVS aims to respond quickly and authoritatively in addressing vaccine-related adverse effects, thereby maintaining ... Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data and Trends in Adverse Drug Reactions. Elsevier. pp. 374-377 ... Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data and Trends in Adverse Drug Reactions. Elsevier. p. 521. ...

https://en.wikipedia.org/wiki/Global_Advisory_Committee_on_Vaccine_Safety

Administration of the drug requires careful monitoring by an anesthesiologist due to potential side effects and serious risks ... trigger a prescription audit to the search for benzodiazepine misuse and for clinically significant adverse reactions related ... patients must be carefully monitorered to prevent recurrence of overdose symptoms or adverse side effects. Flumazenil is also ... The drug has also been used in hepatic encephalopathy. It may have beneficial short‐term effects in people with cirrhosis, but ...

https://en.wikipedia.org/wiki/Flumazenil

... but it may be used alone or with an AChEI because of its low side effect profile. Anticholinergic drugs are avoided because ... benefits, adverse effects, and longer-term usage. Strategies for future intervention involve modifying the course of the ... Sleep-related injuries from falling or jumping out of bed can be avoided by lowering the height of the bed, placing a mattress ... Severe and life-threatening reactions occur in almost half of people with DLB, and can be fatal after a single dose. ...

https://en.wikipedia.org/wiki/Dementia_with_Lewy_bodies

The THC molecule, and related compounds, are usually detectable in drug tests from 3 days up to 10 days according to Redwood ... may alleviate the adverse effects of THC that some users experience, little is known about CBD effects on humans. Cannabinoid ... stroke and other cardiovascular side effects. Marijuana's cardiovascular effects are not associated with serious health ... Other functions such as reaction time, attention, language, reasoning ability, perceptual and motor skills were unaffected. The ...

https://en.wikipedia.org/wiki/Effects_of_cannabis

There is no need for continued presence of the drug to maintain inhibition, which in turn reduced the chance of toxic adverse ... Formestane has been superseded by newer and better inhibitors with better oral availability and fewer side effects, exemestane ... Aromatase is a cytochrome P450 which catalyzes three consecutive hydroxylation reactions, converting C19 androgens to aromatic ... Endocrine-Related Cancer. 21 (1): R31-R49. doi:10.1530/Erc-13-0269. PMID 24434719. Santen, R. J.; Brodie, H.; Simpson, E. R.; ...

https://en.wikipedia.org/wiki/Steroidal_aromatase_inhibitor

A low concentration of the enzyme inhibitor reduces the risk for liver and kidney damage and other adverse drug reactions in ... such drugs are highly specific and generally produce few side effects in humans, provided that no analogous enzyme is found in ... it highlights potential problems with the term used to describe effects relating to the Km. The Km relating to the affinity of ... This protection effect is good evidence of a specific reaction of the irreversible inhibitor with the active site. The binding ...

https://en.wikipedia.org/wiki/Enzyme_inhibitor

But this was not used for long because of adverse side effects. Phenobarbital was the first truly effective drug against ... Barbituric acid can form a large variety of barbiturate drugs by using the Knoevenagel condensation reaction. The structure ... Chloral hydrate (and related trichloroethanol prodrugs) Barbiturates Benzodiazepines Nonbenzodiazepines (e.g., zaleplon, ... The positive side effects were anticonvulsant properties that reduced seizure number and intensity. Pentobarbital is used as a ...

https://en.wikipedia.org/wiki/GABAA_receptor_positive_allosteric_modulator

... drug abuse prevention efforts through legislation allowing the governor to appoint pro tempore judges to deal with drug-related ... Publicity over Mecham's faux pas led to the state experiencing adverse economic effects. Tourism suffered when groups and ... In reaction to these events, a boycott of Arizona was organized. A rift between the Governor and fellow Republicans in the ... This side of Mecham was lost in a fog of controversy that he helped create. Sullivan, Patricia (February 23, 2008). "Evan ...

https://en.wikipedia.org/wiki/Evan_Mecham

No evidence has been found of serious adverse effects on organs or organ systems, and the drug has not been shown to have ... Noteworthy side effects include dry mouth, headache, fatigue, dizziness, intermittent facial oedema, nausea, sleep disturbances ... Media related to Moxonidine at Wikimedia Commons (CS1 maint: uses authors parameter, CS1: long volume value, Articles with ... rarely sedation), asthenia, vasodilatation, and rarely, skin reactions. Rilmenidine Weimann, HJ; Rudolph, M (1992). "Clinical ...

https://en.wikipedia.org/wiki/Moxonidine

The following are the potential adverse effects and their respective incidences: Common (>1% incidence) adverse effects Nausea ... Side effects of moclobemide are exceptionally low, with insomnia, headache and dizziness being the most commonly reported side ... MAOIs such as moclobemide are reported to have a relatively fast onset of action compared to other antidepressant drug classes ... Behavioural toxicity or other impairments relating to everyday living does not occur with moclobemide, except that in doses of ...

https://en.wikipedia.org/wiki/Moclobemide

Adverse effects of fluoroquinolones: irreversible neuropathy is a serious adverse reaction of fluoroquinolone drugs ... The effect of this is to cause symptoms in more than one part of the body, often symmetrically on left and right sides. As for ... Other causes relate to the particular type of polyneuropathy, and there are many different causes of each type, including ... The authors believe amitriptyline may have an effect in some patients but that the effect is overestimated. A 2014 Cochrane ...

https://en.wikipedia.org/wiki/Peripheral_neuropathy

... "forced parent-child separation and parental loss are PTEs with adverse effects on child mental health and academic functioning ... The head of the Justice Department's major crimes unit in San Diego diverted staff from drug smuggling cases. Drug smuggling ... A case study of 91 U.S. born citizens ages 6 to 12, using the UCLA Posttraumatic Stress Disorder Reaction Index and found that ... With the list the Judge believed that the two sides would be able to have "an intelligent conversation Monday (July 9) morning ...

https://en.wikipedia.org/wiki/Trump_administration_family_separation_policy

The most common adverse drug reactions (ADRs) are dose-related and arise from the effect of loop diuretics on diuresis and ... This causes the magnesium and calcium ions to be repelled from luminal side to interstitial side, promoting their absorption. ... effect. Because furosemide, torsemide and bumetanide are technically sulfa drugs, there is a theoretical risk that patients ... effect where there is a maximum level of dosage where further increase in dosage will not increase the clinical effect of the ...

https://en.wikipedia.org/wiki/Loop_diuretic

Adverse reactions were similar among treatment groups and serious adverse events were rare for all treatments. Most chondroitin ... but that there was some evidence of short-term improvement in pain and few side effects; it does not appear to improve or ... as a dietary supplement by the Food and Drug Administration. In Europe, chondroitin sulfate formulations are approved as drugs ... and osteoarthritis-related joint pain, tenderness, and swelling. The FDA denied the request, stating that experiments conducted ...

https://en.wikipedia.org/wiki/Chondroitin_sulfate

While the adverse side-effects with clonidine are inconvenient, the most dangerous aspect of clonidine is withdrawal rebound ... the drug clonidine hydrocloride swept the market as a novel agent for hypertension; however, the reported side-effects (nausea ... where metastatic pheochromocytoma patients underwent PRRT and found that treatment-related adverse events are minimal, with ... which mimicked the reaction of the adrenal medulla. Just four years later, German pathologist Ludwig Pick coined the term " ...

https://en.wikipedia.org/wiki/Pheochromocytoma

... adverse health effects, published and unpublished health and safety studies, and "substantial risks." to the EPA Also, if a ... Exceptions include foods, food additives, drugs, cosmetics or devices regulated under the Federal Food, Drug, and Cosmetic Act ... The report estimated that over half a million children in the United States suffer adverse behavioral reactions as a result of ... lungs or intestinal tract and may induce undesirable genetic changes as a side effect. The regulation of nano particles is ...

https://en.wikipedia.org/wiki/Toxic_Substances_Control_Act_of_1976

The most prevalent research on prescription drugs with side effects of macropsia deals with zolpidem and citalopram. Zolpidem ... and although it has proven beneficial effects, there have been numerous reported cases of adverse perceptual reactions. One of ... there were no lasting residual effects. It is believed that zolpidem-related macropsia is more prevalent in women because ... and neither of the drugs' side effects can be supported by experimental evidence. Citalopram is an antidepressant that inhibits ...

https://en.wikipedia.org/wiki/Macropsia

Because of the potential for more severe side effects, this drug is on the list to avoid in the elderly. In 2015, the European ... These have also been confirmed in both recent and past studies to have no adverse effects on the liver, blood, nervous system, ... but effects related to dyskinesia have also anecdotally been reported after periods of 7.5 months, such as continual head ... Several reactions have been noted in manufacturer guidelines-deep sleep, incoordination, sedation, calmness, and dizziness have ...

https://en.wikipedia.org/wiki/Hydroxyzine

Adverse effects associated with the MMR vaccine include fever, rash, injection site pain and, in rare cases, red or purple ... Most children do not experience any side effects; those that do occur are usually mild, such as fever, rash, pain at the site ... "MEASLES VACCINE - Essential drugs". medicalguidelines.msf.org. Retrieved 28 April 2022. Centers for Disease Control and ... "Information Sheet Observed Rate of Vaccine Reactions" (PDF). World Health Organization (WHO). Archived (PDF) from the original ...

https://en.wikipedia.org/wiki/Measles_vaccine

... reports to the Adverse Drug Reactions Advisory Committee (ADRAC), which evaluates reports of adverse drug reactions for the ... Side effects of testosterone undecanoate include symptoms of masculinization like acne, increased hair growth, voice changes, ... A related testosterone ester with a similarly very long duration is testosterone buciclate. In the late 1970s, testosterone ... Side effects of testosterone undecanoate include virilization among others. The Reandron 1000 formulation (Nebido in the United ...

https://en.wikipedia.org/wiki/Testosterone_undecanoate

... was at levels too low to produce adverse effects. Polystyrene is commonly used in containers for food and drinks. The styrene ... The diastereomer where all of the phenyl groups are on the same side is called isotactic polystyrene, which is not produced ... About 80 years later it was realized that heating of styrol starts a chain reaction that produces macromolecules, following the ... For example, polystyrene meets the stringent standards of the U.S. Food and Drug Administration and the European Commission/ ...

https://en.wikipedia.org/wiki/Polystyrene

Browsing by Subject "Drug-Related Side Effects and Adverse Reactions". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. ... Adverse drug reactions in an Iranian department of adult infectious diseases Kourorian, Z.; Fattahi, F.; Pourpak, Z.; ... This study aimed to assess the frequency and severity of adverse drug reactions [‎ADRs]‎ [‎WHO definition]‎ in hospitalized ... Designing a national combined reporting form for adverse drug reactions and medication errors ...

https://apps.who.int/iris/browse?authority=Drug-Related+Side+Effects+and+Adverse+Reactions&type=mesh

https://extranet.who.int/iris/restricted/browse?authority=Drug-Related+Side+Effects+and+Adverse+Reactions&type=mesh

... features and outcomes of the adverse drug reactions (ADR) among emergency department (ED) visits of S. Giovanni Battista ... Drug Eruptions / etiology * Drug-Related Side Effects and Adverse Reactions* * Emergency Service, Hospital / statistics & ... Adverse drug reactions as cause of visit to the emergency department: incidence, features and outcomes] Recenti Prog Med. 2006 ... The aim of the study was to determine incidence, features and outcomes of the adverse drug reactions (ADR) among emergency ...

https://pubmed.ncbi.nlm.nih.gov/16913173/?dopt=Abstract

... be aware of possible drug reactions. Learn about drug interactions, side effects, and more. ... ClinicalTrials.gov: Drug-Related Side Effects and Adverse Reactions (National Institutes of Health) ... What are side effects?. Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a ... side effects, and allergies.. What is a drug interaction?. A drug interaction is a change in the way a drug acts in the body ...

https://medlineplus.gov/drugreactions.html

Adverse Reactions: Inj-site reactions, infections, diarrhea, abdominal pain, respiratory tract infection, viral infection, ... Drugs. Open Submenu. * Drugs. Back. Drug Search *Browse by Brand. *Browse by Generic ... Pharmacology, adverse reactions, warnings and side effects. ... fatigue; serious infections (may be fatal), infusion-related ... Discontinue immediately if severe hypersensitivity reaction occurs. Risk of hemolysis and other reactions (eg, thrombosis) ...

https://www.empr.com/drug/empaveli/

Drug-Related Side Effects and Adverse Reactions. Chemically-Induced Disorders. Radiation Injuries. Wounds and Injuries. ... Novel Approaches to the Prediction, Diagnosis and Treatment of Cardiac Late Effects in Survivors of Childhood Cancer: A Multi- ... Novel approaches to the prediction, diagnosis and treatment of cardiac late effects in survivors of childhood cancer: a multi- ... Interventions that occur late in the evolution of treatment-related heart disease are usually ineffective at preventing its ...

https://clinicaltrials.gov/ct2/show/NCT01805778

... drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. ... TABLE 1: Number of patients with adverse reactions in the 12-week multiple-dose controlled clinical trial. Adverse Reaction. ... Drugs & Vitamins. Drugs A-Z Generic Drugs A-Z Drugs by Classification Drugs Comparison (Drug Vs. Drug) Vitamins & Supplements ... home drugs a-z list side effects drug center perforomist (formoterol fumarate inhalation solution) drug ...

https://www.rxlist.com/perforomist-drug.htm

Drug-Related Side Effects and Adverse Reactions; Toxicity Tests; DNA Damage; Mutagenicity Tests; Cell Tracking; Consumer ... Torben has experience in drug development within big pharma, assay development in small biotech and providing services as a CRO ... We are dedicated to bringing relevant information to our clients on potential human health hazards of novel and existing drugs ... Torben moved to AstraZeneca in 2014 to support cell assay development and later drug safety assessment and toxicology including ...

https://www.pharmiweb.com/press-release/2021-02-24/toxys-strengthens-executive-team-with-appointment-of-a-cso

Includes common and rare side effects information for consumers and healthcare professionals. ... Learn about the potential side effects of aducanumab. ... reported adverse reactions have included amyloid related ... Some side effects of aducanumab may occur that usually do not need medical attention. These side effects may go away during ... Serious side effects of Aducanumab. Along with its needed effects, aducanumab may cause some unwanted effects. Although not all ...

https://www.drugs.com/sfx/aducanumab-side-effects.html

Occurrence of gastrointestinal side effects may be reduced by avoiding meals around the time of Sandostatin s.c. administration ... Tabulated summary of adverse drug reactions from clinical trials: The following adverse drug reactions (ADRs), listed in Table ... Gallbladder and related reactions: Somatostatin analogues have been shown to inhibit gallbladder contractility and decrease ... Adverse drug reactions from spontaneous reports and literature cases (frequency not known): The following adverse drug ...

https://www.mims.com/malaysia/drug/info/sandostatin/adverse-reactions

Drug-Related Side Effects and Adverse Reactions1. *Nicotine1. *Smoking1 ...

https://profiles.nlm.nih.gov/spotlight/nn/catalog?f%5Breadonly_creator_ssim%5D%5B%5D=Center+for+Health+Promotion+and+Education+%28U.S.%29.+Office+on+Smoking+and+Health&search_field=all_fields&sort=relevance

... but some people do experience side effects and adverse reactions. Vaccinia immune globulin intravenous (VIGIV) is recommended ... Drug. FDA approved for adverse reaction to smallpox (vaccinia) vaccine?. Available through IND protocol for adverse reaction to ... there are limited data on the effectiveness in the treatment of vaccinia-related complications in humans. There are also ... and could be used under an expanded access investigational new drug (IND) protocol for the treatment of adverse reactions ...

https://www.cdc.gov/smallpox/clinicians/vaccine-medical-management6.html

Drug-Related Side Effects and Adverse Reactions. 1. Apnea. 1. Vomiting. 1. ... conventional reversal agent neostigmine is associated with many undesirable side effects. For almost a decade, a new novel drug ... conventional reversal agent neostigmine is associated with many undesirable side effects. For almost a decade, a new novel drug ... Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of ...

https://www.drugpatentwatch.com/p/clinical-trials/profile/drugname/Sugammadex+Sodium

Drug-Related Side Effects and Adverse Reactions @font-face{font-family:Roboto;font-style:normal;font-weight:400;src:url(// ...

https://bvsalud.org/en/multimedia?q=&filter=media_collection_filter%3A%22A+sa%C3%BAde+responde%22

Common side effects of Isentress include trouble sleeping, headache, dizziness, nausea, and tiredness. Serious side effects of ... There were no drug related clinical adverse reactions and three drug-related laboratory adverse reactions (one case of ... What Are the Side Effects of HIV Medications?. Its important to know the potential side effects of all the drugs you take to ... Side Effects of Isentress (raltegravir). *Does Isentress (raltegravir) cause side effects?. *What are the important side ...

https://www.medicinenet.com/side_effects_of_isentress_raltegravir/side-effects.htm

Yes, those dang side effects! I think Cogentin might be worth a shot. But, again, I hope you can have a shot at Tegretol ( ... The two drugs are chemically related. Oxcarbazepine seems to be as potent as carbamazepine in the majority of studies comparing ... I unfortunately did not respond to clomipramine at a high dose and I had an adverse reaction to nortriptyline. ... Yes, those dang side effects! I think Cogentin might be worth a shot. But, again, I hope you can have a shot at Tegretol ( ...

https://dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20220917/msgs/1120773.html

Allergic adverse reactions. Hypersensitive reactions are not dose related yet need earlier exposure to a medication. ... Different types of Adverse Drug Reactions. Adverse drug reactions are (unfavourable impacts) are any undesirable impacts of a ... Adverse Drug Reactions - Types, Symptoms and Side effects. Mukul Das*. Chief scientist, Indian Institute of Toxicology Research ... An Adverse drug reaction (ADR) is an injury occurs by taking drug. ADRs may happen following a single dose or prolonged ...

https://www.rroij.com/open-access/adverse-drug-reactions-types-symptoms-and-side-effects.php?aid=89535

The most common side effect was diarrhea. Use of the drug should be carefully monitored by an experienced hepatologist or ... Serious adverse reactions include endophthalmitis and retinal detachments. The drug was previously approved to treat wet age- ... related macular degeneration and DME and macular edema secondary to retinal vein occlusions. ... A new contraindication also recommends against use of the drug in patients who have had an allergic reaction to any IV iron ...

https://acpinternist.org/archives/2015/06/fda.htm

Drug-Related Side Effects and Adverse Reactions. View Full Text. Read the full text or download the PDF:. ...

https://dtb.bmj.com/content/59/5/71

Drug-Related Side Effects and Adverse Reactions Medicine & Life Sciences 83% * Biomarkers Medicine & Life Sciences 58% ... The protocol would not apply to drugs that are not metabolized or eliminated by a different route. Separate stable isotope- ... The protocol would not apply to drugs that are not metabolized or eliminated by a different route. Separate stable isotope- ... The protocol would not apply to drugs that are not metabolized or eliminated by a different route. Separate stable isotope- ...

https://experts.umn.edu/en/publications/mass-isotopomer-guided-decluttering-of-metabolomic-data-to-visual

Drug and Narcotic Control. Consumer Product Safety. Drug-Related Side Effects and Adverse Reactions. India ... Drug and Narcotic Control1. *Drug-Related Side Effects and Adverse Reactions1 ... Ban bannable drugs ✖Remove constraint Titles: Ban bannable drugs Genre Posters ✖Remove constraint Genre: Posters Copyright ... 1. Ban bannable drugs Publication: New Delhi : Voluntary Health Association of India, [19--] Subject(s): ...

https://collections.nlm.nih.gov/?f%5Bdrep2.rightsFacet%5D%5B%5D=Copyright+may+apply&f%5Bdrep2.subjectAggregate%5D%5B%5D=Consumer+Product+Safety&f%5Bdrep2.subjectGenre%5D%5B%5D=Posters&f%5Bdrep2.titleMain%5D%5B%5D=Ban+bannable+drugs&f%5BdrepX.yearStartInt%5D%5B%5D=1900&f%5Bexample_query_facet_field%5D%5B%5D=years_1950&per_page=100&sort=score+desc

Drug Interactions 84% * Drug-Related Side Effects and Adverse Reactions 11% * Equipment Failure 17% ... Drug Interactions Affecting Antiarrhythmic Drug Use. from the American Heart Association Electrocardiography and Arrhythmias ... Dive into the research topics of Drug Interactions Affecting Antiarrhythmic Drug Use. Together they form a unique fingerprint ...

https://mayoclinic.pure.elsevier.com/en/publications/drug-interactions-affecting-antiarrhythmic-drug-use/fingerprints/?sortBy=alphabetically

A multivariate analysis showed that women had more adverse side effects, especially those related to the gastro-intestinal (GI ... tract (men: 15.2%; women: 18.4%). However, the sex of the patient was not prognostic for GI adverse drug reactions [8]. ... Drugs Aging. 2009;26:769-79. PubMed * Salman S, Sherif B, and Al-Zohyri A. OP0131 Effects of Some Non Steroidal Anti- ... Adverse effects. The safety of ketoprofen was evaluated in a French multicenter study including patients suffering from painful ...

https://janusinfo.se/beslutsstod/janusmedkonochgenus/janusmedsexandgender/database/ketoprofen.4.492f438316ec5fbe712102a5.html

Adverse reactions, Congenital bilateral absence of the vas deferens, Drug-related side effects, Elexacaftor, Infertility, Male ... Title: Study that tested the effects of a new drug called acebilustat in adultswith cystic fibrosis ... Title: New drug for cystic fibrosis does not significantly interfere with another drug that prevents organ rejection ... Title: Drug-Induced Liver Injury from Elexacaftor/Ivacaftor/Tezacaftor Authors Sarah Lowry; Peter J. Mogayzel, Jr.; Kiyoko ...

https://www.ecfs.eu/publications/resources?page=1

With the exception of epilation, leukopenia and neurologic side effects, adverse reactions generally have not persisted for ... Related Resources. Medline Plus, Clinical Trials, PubMed, Biochemical Data Summary More Info on this Drug. View Labeling ... Because many drugs are excreted in human milk and because of the potential for serious adverse reactions from vinblastine ... Side effects following the use of vinblastine sulfate are dose related. Therefore, following administration of more than the ...

https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f073b58e-56d6-4c8d-a2ce-b37719402d77

Liver damage is a possible adverse reaction of JAK inhibitor use. And these drugs are contraindicated in patients with ... Effect of filgotinib on health-related quality of life in active psoriatic arthritis: a randomized phase 2 trial (EQUATOR). ... The drug was well-tolerated, and safety and side effects were similar to those of disease-modifying anti-rheumatic drugs ( ... Possible Side Effects There are side effects common to all JAK inhibitors, and each JAK inhibitor has its own list of potential ...

https://www.verywellhealth.com/jak-inhibitors-4706526

Drug-Related Side Effects and Adverse Reactions. *Diagnostic Techniques and Procedures. *Injections, Spinal ... Shortage of drugs also occur frequently. Medication errors related to drug shortages can be reported to the Medication Error ... Nephrogenic systemic fibrosis: a serious adverse reaction to gadolinium - 1997-2006-2016. Part 1. Acta Radiol 2016;57:515-20. ... Patients at risk of adverse events, such as patients with suspected intrathecal drug delivery system malfunction, who are in ...

https://rapm.bmj.com/content/47/9/511

Drug-Related Side Effects and Adverse Reactions Medicine & Life Sciences 33% * Infections Medicine & Life Sciences 17% ... We will also discuss features of drug-related toxicities, infections, and environmental toxins that comprise the main entities ... We will also discuss features of drug-related toxicities, infections, and environmental toxins that comprise the main entities ... We will also discuss features of drug-related toxicities, infections, and environmental toxins that comprise the main entities ...

https://jhu.pure.elsevier.com/en/publications/rheumatoid-arthritis-associated-interstitial-lung-disease-diagnos-3

... was medication side effects. However, frequency of adverse drug reactions reported by patients in interviews did not differ ... also might be related to experiencing more side effects by the patients who received a higher number of toxic second-line drugs ... for healthcare providers about management of adverse drug reactions and patient education about expected adverse drug reactions ... The most commonly reported primary reason for loss to follow-up was medication side effects or fear of side effects. ...

https://wwwnc.cdc.gov/eid/article/22/3/15-1788_article

Its a prescription drug that treats schizophrenia and depressive episodes of bipolar I disorder. ... Learn about side effects and more of Latuda (lurasidone). ... drug interactions, allergic reactions, or adverse effects. The ... For depressive episodes related to bipolar disorder, you may use the drug either short term or long term. Your doctor can ... Serious side effects. Serious side effects from Latuda can occur, but they arent common. If you have serious side effects from ...

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The most common side effects were headache, back pain, nausea, and infusion site pain and swelling. (acpinternist.org)
About 60 percent of those who got Gardasil or the aluminum placebo had systematic adverse events including headache, fever, nausea, dizziness, vomiting, diarrhea or myalgia. (newswithviews.com)
Though few adverse reactions were noted in the present study, some side effects have been associated with the use of flu antiviral drugs, including nausea, vomiting, dizziness, runny or stuffy nose, cough, headache and some behavioral side effects. (cdc.gov)
The most common side effects of HALAVEN in adults with liposarcoma include tiredness, nausea, hair loss (alopecia), constipation, stomach pain, and fever. (halaven.com)
does losartan alone lower your blood pressure These include a direct effect on blood pressure, tension, nausea, and optimality, and skin. (jewishledger.com)
The most common adverse reactions are gastrointestinal disturbances ( nausea , vomiting , anorexia) and allergic skin reactions (such as rash and urticaria). (mdtodate.com)

But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies. (medlineplus.gov)
Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work. (medlineplus.gov)
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (drugs.com)
Drug interactions of Isentress include medicines which alter the activity of UGT1A1 enzymes, such as rifampin, which may affect blood levels of Isentress. (medicinenet.com)
1 For example, some patients may be more prone than others to experience potential drug interactions or to have comorbidities that can affect how patients are managed with oral therapy. (physiciansweekly.com)
Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals. (bvsalud.org)
The objective in this study was to survey the potential pairs of drug interactions administered at the same time at a psychiatric emergency service of a general hospital during the first twenty-four hours of care. (bvsalud.org)
The database Drugs® informed that, of all pairs administered during that period, 559 (36%) presented possible interactions, while 978 (64%) had no signs of interaction risk. (bvsalud.org)
Based on the findings, a figure was elaborated with the main care for possible interactions between drugs used in psychiatric emergency care. (bvsalud.org)

Core 1 (Genomics) will focus on determining which children are most susceptible to treatment-related cardiac toxicity by assessing genes in pathways related to anthracycline absorption, distribution, metabolism, and excretion, as well identifying genes in pathways known to be important in the cardiac response to injury. (clinicaltrials.gov)
Core 2 (Biomarkers) will explore whether existing and novel biomarkers allow for more accurate diagnosis of acute and late treatment-related cardiac toxicity. (clinicaltrials.gov)
Patients being treated with cidofovir have experienced serious renal toxicity and other adverse events that have not been observed in patients being treated with brincidofovir. (cdc.gov)
Metabolomics offers the opportunity to uncover endogenous biomarkers that can lead to metabolic pathways and networks and that underpin drug toxicity mechanisms. (umn.edu)
A novel protocol is presented and discussed that is applicable to drugs which generate urinary metabolites when administered to mice sensitive to its toxicity. (umn.edu)
Since the major route of excretion may be through the biliary system, toxicity from this drug may be increased when there is hepatic excretory insufficiency. (nih.gov)
Each oral therapy is associated with its own unique toxicity profile, meaning that dose modifications and adjustments may vary from drug to drug. (physiciansweekly.com)
If a dose adjustment is necessary, the goal should be to do so while maintaining maximum drug efficacy without increasing toxicity. (physiciansweekly.com)
The difficulty in distinguishing this entity from other CNS disease-related complications (e.g. leukemia infiltration, drug toxicity, hemorrhages) should not lead to an underestimation of the true incidence of this complication. (elsevier.com)
This study was conducted to correlate serum levels of markers of immune activation with mortality and drug toxicity in HIV +TB. (bvsalud.org)
Immune activation in HIV +TB is associated with shortened survival and increased risk of drug toxicity . (bvsalud.org)
Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. (medscape.com)

Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. (drugs.com)
Adverse drug reaction (ADE) alludes to any injury happening at the time a medication is utilized, regardless of whether it is distinguished as a reason for the injury. (rroij.com)
Adverse drug reactions are (unfavourable impacts) are any undesirable impacts of a medication. (rroij.com)
Dose related unfavourable medication responses address a misrepresentation of the medication's restorative impacts. (rroij.com)
Hypersensitive reactions are not dose related yet need earlier exposure to a medication. (rroij.com)
Compared with treatment for drug-susceptible TB, treatment for MDR TB is longer, more expensive, and less effective, and it causes more medication side effects ( 2 - 5 ). (cdc.gov)
Medication errors related to drug shortages can be reported to the Medication Error Reporting site ( https://www.ismp.org/report-medication-errorsite ) on the Institute for Safe Medication Practices (ISMP) website. (bmj.com)
Following both rounds of the Delphi exercise, 13 outcomes (organised into seven overarching domains: medication appropriateness, adverse drug events, prescribing errors, falls, quality of life, all-cause mortality and admissions to hospital (and associated costs)) met the criteria for inclusion in the final COS. (elsevier.com)
Advocate that midlevel providers receive hospital-based training in the prevention of medication-related adverse events. (the-hospitalist.org)
The elderly portion of the population is expanding more rapidly than the population as a whole, and the recognition and prevention of medication side effects in this group is one of the most critical safety and economic issues facing the healthcare system today. (the-hospitalist.org)
Uses as: Flaxseed Herbs with Similar Warnings as: Ephedra Herbs with Similar Side Effects as: Skullcap Herbs with Similar Uses as: Arnica Herbs with Similar Uses as: Flaxseed Herbs with Similar Uses as: Peppermint Herbs with Similar Side Effects As any medication Tadalafil can be very dangerous to your cart. (sovyota.com)
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient. (entirelypetspharmacy.com)
Several users report no significant side effects from this medication. (rxgenericdb.com)
Once you get the right combination, patient's improve without the significant potential side effects of medication. (healthyplace.com)
This medication is a corticosteroid hormone, injectable steroid side effects. (marikaannecountouris.com)
The use of biopuncture injection therapy can benefit those patients who have tried conventional medicine but have had no success, or those who want to avoid the side effects associated with many conventional medication treatments. (optimumhealthrehab.com)
Medication interaction happens when the power or efficiency of one drug is altered by the presence of another. (bvsalud.org)
The medication used during psychiatric emergencies is aimed at reducing and/or putting an end to symptoms related to the behavioral change, almost always symptoms of psychomotor agitation and aggressiveness. (bvsalud.org)
Self-medication is defined as obtaining effects and contraindications of the medicines (10). (bvsalud.org)

The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). (elsevier.com)

Discontinue immediately if severe hypersensitivity reaction occurs. (empr.com)
Hypersensitivity and allergic reactions have been reported during post-marketing experience. (mims.com)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Naprosyn (Naproxen) where reactions include drug hypersensitivity. (druglib.com)

This study aimed to assess the frequency and severity of adverse drug reactions [‎ADRs]‎ [‎WHO definition]‎ in hospitalized adult patients in an infectious diseases referral ward in Tehran. (who.int)
The following adverse drug reactions (ADRs), listed in Table 1, have been accumulated from clinical studies with octreotide: Adverse drug reactions (Table 1) are listed by MedDRA system organ class. (mims.com)
ADRs are just one kind of drug related damage, as mischief can likewise be brought about by overlooking to take demonstrated medicines. (rroij.com)
Adverse drug reactions (ADRs) are a major public health concern and cause significant patient morbidity and mortality. (elsevier.com)
To date, at least 244 pharmacogenes identified have been associated with ADRs of 176 clinically used drugs based on PharmGKB. (elsevier.com)
At least 28 genes associated with the risk of ADRs have been listed by the Food and Drug Administration as pharmacogenomic biomarkers. (elsevier.com)

Dose related responses might be not serious, however they are moderately normal. (rroij.com)
In some patients, dose modifications or interruptions may be considered when managing treatment-related ARs. (physiciansweekly.com)
With early intervention and appropriate management of side effects, when possible, clinicians can increase their likelihood of helping patients avoid unnecessary dose reductions, interruptions, or even early treatment discontinuation. (physiciansweekly.com)
dose adjustments required for age-related ↓ in renal function and body weight. (drugguide.com)
When starting a new drug, start with a low dose and titrate slowly to the desired clinical effect. (the-hospitalist.org)
After observing that the patient tolerates the new drug, slowly increase the dose until the desired result is obtained. (the-hospitalist.org)
Area under the curve (AUC) is a measure of drug exposure and depends on dose, absorption, metabolism, and clearance etc. (janusinfo.se)
Bioequivalence is considered to exist in two products with the same active substance if the bioavailability after administration of the same dose is so similar that they get the same effect and side effects. (janusinfo.se)
How large plasma volume that has been purified of the drug at a specific time unit is calculated by dividing the given dose with AUC. (janusinfo.se)
During pregnancy, the distribution volume can change significantly for certain drugs, which may require dose adjustment. (janusinfo.se)
Individually titrate oxycodone hydrochloride tablets to a dose that provides adequate analgesia and minimizes adverse reactions. (nih.gov)
This is most likely an effect of the lower dose most bodybuilders take compared to athletes or others attempting to treat an ailment with the drug. (robertogiraldo.com)
Hair loss is only with your next dose, skip the missed dose as soon as prejudice against theoretical, miracles of this drug because generic viagra Free express and regular expense. (sovyota.com)
The adverse effects due to Lidocaine mainly involve the CNS, are usually of short duration, and are dose related. (inceptapharma.com)
Associate professor at UCL Dr. Ravi Das said that the results shown at week 3 were positive yet not 'spectacular' for psychiatric treatment and that the study reveals "some evidence for greater incidence of adverse effects" as referred to the three reported cases of suicidal behavior in the highest dose group, and lastly pointed out that there were "significantly fewer severely depressed people in the apparent 'effective' (25mg) dose group. (businessinsider.com)
The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. (cdc.gov)

The uptake in the body depends on the dosage forms chemical and physical properties, physiologic factors (e.g. pH in the gastrointestinal tract), gastrointestinal mobility, and first-pass metabolism, blood flow at the absorption) and interaction with other drugs and food. (janusinfo.se)
Your doctor will prescribe the smallest dosage that provides the desired effect. (medicalnewstoday.com)
If these are not sufficient, we will usually add an antidepressant to the program, using as low a dosage as possible to try to avoid adverse effects. (healthyplace.com)
Frequently, when using various non-drug adjuncts, the dosage of antidepressant can be much lower. (healthyplace.com)

In rare instances, gastrointestinal side effects may resemble acute intestinal obstruction, with progressive abdominal distension, severe epigastric pain, abdominal tenderness and guarding. (mims.com)
Tecovirimat has been used in a small number of individuals to date for the treatment of severe adverse events resulting from vaccinia virus vaccination, and effectiveness data in humans is limited. (cdc.gov)
These reactions can be severe or life-threatening if not treated promptly. (medicinenet.com)
Even though these can be severe and even life-threatening, assaying for allergic IRs before a drug gets to clinical phases is challenging because relevant biomarkers or animal models are scarce. (europa.eu)
The energy sources may cause severe side effects. (sovyota.com)
Severe withdrawal symptoms including delirium and seizures can occur if the drug is stopped abruptly. (sleepaidguide.com)
Rarely will this drug cause a very severe allergic reaction. (rxgenericdb.com)
But you should seek medical attention right away if you experience any serious allergic reaction symptoms, such as a persistent fever, new or worsening lymph node swelling, rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing. (rxgenericdb.com)
There aren't usually any severe side effects if you take steroid injections, a steroid inhaler, or a short course of steroid tablets. (marikaannecountouris.com)
Severe cerebrovascular disease like change in strength on one side is greater than the other, trouble speaking or thinking, change in balance, or vision changes. (genericonlinemedicine.com)

Vaccine-safety-related events, and how we respond to them, can affect public trust in vaccines and health authorities. (who.int)
The vaccinia virus vaccines ( smallpox vaccine ) are generally safe and effective, but some people do experience side effects and adverse reactions . (cdc.gov)
A freedom of information request from the group Judicial Watch in May of this year discovered that during the period from June 8, 2006 - when the vaccines received approval from the U.S. Food and Drug Administration (FDA) to May 2007 there were 1,637 reports of adverse reactions to the HPV vaccine reported to the FDA. (newswithviews.com)
We bring you this is international news regarding the continuing investigations going on in Japan regarding the numerous reports of injuries and deaths related to the HPV vaccines. (healthimpactnews.com)
The International Symposium on the adverse reactions experienced by girls who have been vaccinated by Human Papillomavirus vaccines and subsequent events which took place in Tokyo on February 25th and 26th have sparked a high-profile debate over HPV vaccine safety, efficacy and need. (healthimpactnews.com)
The public hearing was attended by eight medical academic members of the Japanese government's Advisory Council on the Alleged Adverse Reactions to HPV Vaccines, several top-ranking Health Ministry bureaucrats, medical doctors and journalists from the nation's major newspapers and television networks. (healthimpactnews.com)
COVID-19 vaccines: Update on Allergic Reactions, Contraindications, and Precautions. (cdc.gov)
VAERS is the nation's early warning system for vaccine safety and provides the quickest information on adverse events and quickest information to allow us to characterize the safety profile of newly authorized vaccines when they are recommended in the population. (cdc.gov)
Since the roll-out of the COVID-19 gene-based vaccines began last December, with adverse reactions, including death, being passively reported on the CDC's Vaccine Adverse Events Reporting System (VAERS), many have believed the actual numbers of injuries to be much higher. (coronafraud.com)

Anaphylaxis , a serious allergic reaction, is less common. (medlineplus.gov)
A new contraindication also recommends against use of the drug in patients who have had an allergic reaction to any IV iron replacement product. (acpinternist.org)
Incase of eye drops ocular burning sensation or allergic reaction may occur in 5-10% patients. (inceptapharma.com)

Interventions that occur late in the evolution of treatment-related heart disease are usually ineffective at preventing its progression to death or heart transplant. (clinicaltrials.gov)
Although not all of these side effects may occur, if they do occur they may need medical attention. (drugs.com)
Some side effects of aducanumab may occur that usually do not need medical attention . (drugs.com)
Shortage of drugs also occur frequently. (bmj.com)
Serious side effects from Latuda can occur, but they aren't common. (healthline.com)
But, these side effects may occur at any time during treatment. (healthline.com)
What are the side effects that occur with legitimate intake of the drug? (robertogiraldo.com)
Moreover, the energy absorbed by the tissues within the skin cannot be correctly predicted and side effects such as hormonal disorders often occur. (bestviewbeauty.com)
Side effects that may occur, are tenderness to the injection site, swelling of the area, redness or warming in the chest or face, or a temporary increase in. (marikaannecountouris.com)
Although corticosteroid injections are simple to perform and the risk-benefit ratio is highly favorable, some adverse side effects do occur. (marikaannecountouris.com)

Aspartic acid was relatively ineffective in reversing the antitumor effect. (nih.gov)
These alternatives are costly, ineffective for a long term use, and have potential serious side effects. (makatimed.net.ph)

To prevent a polypharmacy-induced iatrogenic illness, it is important to consider any new signs and symptoms to be a possible consequence of current drug therapy. (the-hospitalist.org)
People with acid reflux or GERD should not take the drug, because it worsens symptoms and increases their duration. (sleepaidguide.com)
Anthony Cleare , professor of psychopharmacology at King's College London, is of the opinion that "there are several issues that need further study before this can become part of regular clinical practice," including psilocybin's potential worsening of existing symptoms as part of side effects within a larger patient population. (businessinsider.com)
however, they showed a lack of knowledge regarding signs and symptoms related to an overdose of local anesthetics. (bvsalud.org)
Joint injections are used if only a few joints are affected and other drugs do not relieve symptoms. (marikaannecountouris.com)

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. (medicinenet.com)
Drug development proceeds along a regulated pathway from innovation and research to preclinical and clinical trials to review by national authorities. (europa.eu)
Many drugs do not make it through clinical trials due to unpredicted adverse side effects in people. (europa.eu)
The main functions of MRAs are to issue licenses to pharmaceutical companies, evaluate their products, carry out medicines inspections, control and monitor the quality of medicines circulating on the local market, authorize clinical trials, oversee medicines promotion and advertising, conduct surveillance of adverse reactions to medicines and provide medicines-related information. (who.int)
The following adverse reactions associated with the use of BACTRIM or sulfamethoxazole and trimethoprim were identified in clinical trials, postmarketing or published reports. (mdtodate.com)

The most commonly reported adverse reactions have included amyloid related imaging abnormalities, headache, and falls. (drugs.com)
Common side effects include headache . (mdwiki.org)

The value of testing for key genetic markers associated with poor metabolism of medications has now become internationally accepted as a way to prevent some adverse drug reactions in individuals, and to identify those at risk of side effects,' said Paul Debenham, director of Life Sciences at LGC. (wral.com)
Information about new psychotropic drugs, a summary of advances in knowledge about identifiable risk factors for adverse effects, and updated recommendations on viable antidote management strategies-including novel pharmacotherapies for tardive dyskinesia and newer agents for weight loss-are among the features of this new, second edition of Managing the Side Effects of Psychotropic Medications . (appi.org)
Busy clinicians will find in Managing the Side Effects of Psychotropic Medications an accessible reference that provides both scientific and scholarly discussion of the consequences of drug therapies they may prescribe (or avoid), the range of available strategies to effectively manage adverse effects, and the scientific and practical implications of their treatment decisions. (appi.org)
However, users experiencing significant itching would do well to consult their doctor regarding prescription-strength treatment options before using alternative medications for this side effect. (robertogiraldo.com)
Among these factors are: one's diet, toxic factors (such as artificial sweeteners), suboptimal levels of vitamins and minerals like the B complex, magnesium and zinc, hormonal imbalances, deficiency of various neurotransmitters (such as serotonin or dopamine), lack of activity and exercise, adverse effects of many medications (such as blood pressure medications and even antidepressants) and diseases (such as Lyme disease). (healthyplace.com)
There are forms of treatment that require the use of very strong immunosuppressive drugs, over-the-counter topical medications, steroids, and other systemic drugs. (makatimed.net.ph)

Serious adverse reactions include endophthalmitis and retinal detachments. (acpinternist.org)
Uncommon but serious adverse reactions and significantly improving erection. (sovyota.com)
Black box warnings are reserved for drugs that can cause serious adverse reactions. (sleepaidguide.com)

Brincidofovir may have fewer adverse events than cidofovir (which is FDA-approved for the treatment of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome). (cdc.gov)
Bleeding and major complications with the arteries were the most common early adverse events. (acpinternist.org)
Adverse events were predominantly of grade 1, and no adverse event of grade 3 or 4 that was considered by the investigators to be related to larotrectinib occurred in more than 5% of patients. (elsevier.com)
No patient discontinued larotrectinib owing to drug-related adverse events. (elsevier.com)
The costs of adverse drug events in hospitalized patients. (the-hospitalist.org)
Adverse Drug Events Prevention Study Group. (the-hospitalist.org)
At the six-year follow-up, the type and frequency of adverse events were similar to previously reported profiles. (novartis.com)
Newly occurring or worsening grade 3 or 4 hematologic or biochemical adverse events were infrequent. (novartis.com)
The secondary endpoints included hemodynamics, the duration of induction, the duration of insertion, tidal volume, plateau pressure and adverse events. (bvsalud.org)
although these two adverse events occurred independently. (bvsalud.org)
Thiopurine methyltransferase (TPMT) heterozygosity and enzyme activity as predictive tests for the development of azathioprine-related adverse events. (cdc.gov)
That primarily involves recognizing, responding, and reporting anaphylaxis cases following COVID-19 vaccination to VAERS and reporting adverse events to VAERS in accordance with the FDA Emergency Use Authorization reporting requirements and CDC guidance. (cdc.gov)
Dr. Natalie Gukasyan , a psychiatrist and post-doctoral research fellow at that same university, launched a Twitter thread regarding the definition of adverse events in psychedelics and their significance in a relatively small sample of people with TRD. (businessinsider.com)
The most recent data from the CDC's VAERS system released last Friday reveals reports of 726,965 adverse events in the U.S. following vaccination, including 15,386 reports of deaths and 99,410 reports of serious injuries, between December 14, 2020, and September 17. (coronafraud.com)
In addition, even vaccine manufacturers have calculated at least a "fifty-fold underreporting of adverse events" on this system. (coronafraud.com)
Displaying data of Medicare beneficiaries in the State of New York alone revealed thousands of cardiovascular events, cases of COVID-19, and deaths among a total of 16 tracked adverse events. (coronafraud.com)
Reports of adverse events were subsequently made through the event-based surveillance system, mostly from the Zamboanga Peninsula on the island of Mindanao. (who.int)
A team from the Epidemiology Bureau investigated the reports of adverse events following mass drug administration (AEFMDA). (who.int)
On the day of the NSDD, cases of adverse events following mass drug administration (AEFMDA) were reported to the national event-based surveillance system from schools, health centres and hospitals. (who.int)

No antivirals are currently approved by the FDA for treatment of complications which might arise from vaccinia vaccination, but some may be used under expanded access investigational new drug (IND) protocols. (cdc.gov)
however, there are limited data on the effectiveness in the treatment of vaccinia-related complications in humans. (cdc.gov)
Male sex and high age carried a higher risk of complication and suggested a synergistic effect between these factors and NSAIDs on the risk of upper gastrointestinal complications. (janusinfo.se)
Where other psychopharmacology textbooks-and, indeed, most internships and residencies in psychiatry-lack a solid basis in primary care medicine, this guide bridges that educational gap, offering a thorough examination of all the effects of taking a psychotropic drug as well practical clinical advice on how to manage complications that arise. (appi.org)
The patients in this double-blind, randomized, placebo-controlled study were mostly children (average age: 5 years) in an urban setting in Bangladesh with laboratory-confirmed influenza infection and no additional flu-related complications. (cdc.gov)
Observational studies suggest that antiviral drugs also can prevent serious flu complications, like pneumonia. (cdc.gov)
CDC recommends that antiviral drugs be used as early as possible in people who are very sick with the flu (for example, hospitalized patients) and people who are sick with the flu and have a greater chance of getting serious flu complications, either because of their age or because they have a medical condition that places them at high risk from influenza complications. (cdc.gov)
complications or recing the release of balance, and making a family history kedi drugs for high blood pressure of cardiovascular diseases. (jewishledger.com)
Treatment dosages are determined by the attending dermatologist to avoid complications and adverse reactions. (makatimed.net.ph)
In addition to the pharmacological side effects of anabolic steroids, complications may also result from the injection technique used in self administration. (marikaannecountouris.com)

serious infections (may be fatal), infusion-related reactions. (empr.com)
The drug can also cause serious side effects, including IV infusion-related reactions. (medscape.com)

Gentris plans to use the technology to help reduce adverse drug reactions. (wral.com)
Novel Drug Delivery System (NDDS): Development of nanotechnology-based, sustained release and targeted delivery formulations with NDDS to reduce adverse drug reactions and side-effects in the therapeutic areas of oncology, NSAID, neuro science, arthritic disorders, stress and lifestyle related diseases, immuno chemistry, infectious diseases and wound healing. (blogspot.com)

The most frequent adverse reactions reported during octreotide therapy include gastrointestinal disorders, nervous system disorders, hepatobiliary disorders, and metabolism and nutritional disorders. (mims.com)
Some of the idiosyncratic reactions include rashes, jaundice, a decline in the thrombocytes count, kidney injury, and nerve injury that may weaken vision or hearing. (rroij.com)
These lists don't include all possible side effects. (healthline.com)
The skills covered in this section of the PANRE include selecting pharmacological therapy for selected medical conditions, monitoring pharmacologic regimens and adjusting as appropriate, and evaluating and reporting adverse reactions. (testprepreview.com)
The skills necessary to succeed in this task area include recognizing normal and abnormal anatomy and physiology, relating pathophysiologic principles, correlating abnormal physical examination findings, and correlating abnormal results of diagnostic tests to a given disease process. (testprepreview.com)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Diovan HCT (Valsartan / Hydrochlorothiazide) where reactions include blood pressure fluctuation. (druglib.com)
[1] Other side effects may include allergic reactions, low blood pressure , QT prolongation , and priapism . (mdwiki.org)
Occasionally skin rash, peripheral oedema and abnormalities of serum transaminase have been reported.Very rarely reported side effects include activation of peptic ulcer, haematemesis or melena, blood dyscrasia (extensive usage). (inceptapharma.com)
Other research limitations so far would include the difficulty of finding a sound placebo, over-representation of certain participants -namely white and college-educated, with prior hallucinogenic experience and an interest in spirituality, difficulty in understanding if and how the work of patients with therapists impacts their treatments vis-a-vis the drug itself, and standardizing the treatment outside supervised trials. (businessinsider.com)

Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis. (nih.gov)
Most side effects were transient and consisted of mild local reactions at the injection site, with a higher rate of local reactions in the active treatment group compared with the placebo group. (medscape.com)
According to the Centers for Disease Control and Prevention (CDC), one is not considered as being "vaccinated" until 14 days after their completed injection regimen, raising the question of whether government authorities have been classifying these fatalities as something other than vaccination-related deaths. (coronafraud.com)
Generally, pain after cortisone injection is the most common side effect. (marikaannecountouris.com)
While the injection is going to work quickly, there are some side effects to consider. (marikaannecountouris.com)

Safety and efficacy of the new indication were based on 2 trials with 679 participants showing significant improvement in severity of DR. The most common side effects are bleeding of the conjunctiva, eye pain, cataracts, floaters, increased intraocular pressure, and vitreous detachment. (acpinternist.org)
Among 91 case-patients (those lost to follow-up) and 182 control-patients (those who adhered to treatment), independent factors associated with loss to follow-up included patients' higher self-rating of the severity of vomiting as an adverse drug reaction and alcohol abuse. (cdc.gov)

Side effects are unwanted, usually unpleasant, effects caused by medicines. (medlineplus.gov)
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. (drugs.com)
The use of inefficacious and low-quality medicines causes treatment failures, aggravates side effects and leads to drug resistance. (who.int)
A medicines regulatory authority should have a national medicines policy and related legislation as well as norms, guidelines, procedures and adequate financial and human resources. (who.int)

Data from a large placebo-controlled US study that compared the safety of another longacting beta 2 -adrenergic agonist (salmeterol) or placebo added to usual asthma therapy showed an increase in asthma-related deaths in patients receiving salmeterol. (rxlist.com)
Although Isentress does not cure HIV or AIDS , continuous HIV treatment with Isentress can help patients control the infection and decrease their risk of acquiring HIV-related illnesses. (medicinenet.com)
Some patients taking raltegravir experience serious skin and allergic reactions. (medicinenet.com)
The drug is contraindicated in such patients and all patients should be evaluated for lung disease, with history, physical, and spirometry, before starting the drug. (acpinternist.org)
The annual number of patients with drug-resistant TB who began receiving treatment under PMDT increased from 191 in the 2005 cohort to 2,056 in the 2012 cohort. (cdc.gov)
I attribute the Paleo diet, exercise and attitude with my turn around and am totally drug free, train regularly (lift, swim sprint and run), and encourage other patients with IPF to follow the Paleo lifestyle. (robbwolf.com)
The review was triggered by a notice about international reports of bone-related side effects experienced in patients taking the SGLT2 inhibitor canagliflozin. (canada.ca)
With use of dapagliflozin, these risks were only identified in patients who had kidney problems.No evidence of bone-related side effects was found to date with the use of empagliflozin. (canada.ca)
Health Canada will mention the update in the Health Product InfoWatch , to inform physicians about the potential risk of bone-related side effects in patients treated with canagliflozin, and to consider factors that contribute to the fracture risk. (canada.ca)
Prior to initiating oral therapy, clinicians should educate patients about the potential treatment-related adverse reactions (ARs). (physiciansweekly.com)
To optimize treatment of mRCC with oral therapies, clinicians must proactively monitor patients at each visit for ARs, comorbidities, and difficulties with drug adherence. (physiciansweekly.com)
ABSTRACT We aimed to study the prevalence of the side-effects of statins among Iranians patients admitted to a cardiac-specialized hospital and had taken statins prior to hospitalization. (who.int)
RÉSUMÉ Nous avions l'objectif d'étudier la prévalence des effets secondaires causés par les statines chez des patients iraniens admis dans un hôpital spécialisé en cardiologie et sous traitement par statines avant leur hospitalisation. (who.int)
Reduction of high-risk polypharmacy drug combinations in patients in a managed care setting. (the-hospitalist.org)
With a unique six-year record of safety and efficacy, Gleevec remains the first-line drug therapy for all patients with Ph+ CML. (novartis.com)
auto parts stores nearby Strattera is a prescription drug that is used with behavioral and psychological therapies to help patients diagnosed with attention-deficit hyperactivity disorder (ADHD) to focus. (cassefortisicure.it)
Although pseudoephedrine has virtually no pressor effects in normotensive patients, CETAL SINUS should be used with caution in patients suffering from mild to moderate hypertension. (eipico.com.eg)
The US Food and Drug Administration (FDA) today approved isatuximab ( Sarclisa , Sanofi) in combination with pomalidomide ( Pomalyst , Celgene) and dexamethasone for the treatment of adult patients with multiple myeloma who have received two or more prior therapies including lenalidomide and a proteasome inhibitor. (medscape.com)
While there is no cure for multiple myeloma, Sarclisa is now another CD38-directed treatment option added to the list of FDA-approved treatments of patients with multiple myeloma who have progressive disease after previous therapies," said Richard Pazdur, MD, director of the FDA's Oncology Center of Excellence and acting director of the Office of Oncologic Diseases in the FDA's Center for Drug Evaluation and Research. (medscape.com)
The FDA notes there have been higher incidences of second primary malignancies observed in a controlled clinical trial of patients with multiple myeloma receiving the drug. (medscape.com)
The FDA also highlighted that laboratory test interference may be caused by isatuximab and that blood banks should be informed that patients are receiving the drug. (medscape.com)
When tuberculosis cases are treated, poor drug prescription and poor case management are creating more tuberculosis patients excreting resistant tubercle bacilli. (who.int)
Your loaded coupons will be receiving genuine drugs from the market when patients developed serious heart danger. (sovyota.com)
Patients were treated with either oseltamivir (a type of flu antiviral drug known as a "neuraminidase inhibitor") or a placebo (e.g., a shot of saline). (cdc.gov)
Baloxavir is given to patients with this icon indicate that you are a type of diagnostic testing for BRCA-related cancers and their most recent year for the procedure. (personallicencecourses.com)
Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism. (cdc.gov)
Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease. (cdc.gov)
Risk factors for serious adverse effects of thiopurines in patients with Crohn's disease. (cdc.gov)
Association between thiopurine S-methyltransferase polymorphisms and thiopurine-induced adverse drug reactions in patients with inflammatory bowel disease: a meta-analysis. (cdc.gov)
TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects. (cdc.gov)
Even some kedi drugs for high blood pressure of the patients with diabetes may be expected to the factor for heart attacks and heart attacks. (jewishledger.com)
The rationale for using therapeutic drug monitoring in relation to second-generation antipsychotics is still being discussed at least with regard to the real clinical utility, but there is evidence that it can improve efficacy, especially when patients do not respond or develop side effects using therapeutic doses. (researchgate.net)
The population relates to the histories of patients attended at the emergency service of the HCU-UFU, in the specialty area psychiatrics, in 2012. (bvsalud.org)

Occurrence of gastrointestinal side effects may be reduced by avoiding meals around the time of Sandostatin s.c. administration, that is, by injecting between meals or on retiring to bed. (mims.com)

The therapeutic responses, however, are not fully explained by the cytologic changes, since these changes are sometimes observed clinically and experimentally in the absence of any oncolytic effects. (nih.gov)
Thyroid hormones may ↓ therapeutic effects. (drugguide.com)
Therapeutic drug monitoring studies have generally concentrated on controlling compliance and avoiding side effects by maintaining long-term exposure to minimally effective blood concentrations. (researchgate.net)
At the same time, the depth of microcrystalline penetration and the amount of RF energy can be adjusted according to the different degrees of adaptation, doubling the therapeutic effect. (bestviewbeauty.com)
Finally, Transdermal multi-drug delivery, brightening and rejuvenation: personalized therapeutic drug delivery along the channels created by the microcrystals for better results. (bestviewbeauty.com)

Targeted therapies for renal cell carcinoma: review of adverse event management strategies. (physiciansweekly.com)

We will also discuss features of drug-related toxicities, infections, and environmental toxins that comprise the main entities in the differential diagnosis of RA-ILD. (elsevier.com)

In very rare instances, acute pancreatitis has been reported within the first hours or days of Sandostatin s.c. treatment and resolved on withdrawal of the drug. (mims.com)

It may be confused with a variety of other dermatologic diseases that are similar in appearance, including atopic dermatitis (eczema), maculopapular drug eruptions, contact dermatitis, insect bites, erythema multiforme , pityriasis rosea , and others. (medscape.com)

This practice-oriented handbook surveys current knowledge on the prediction and prevention of adverse drug reactions related to off-target activity of small molecule drugs. (ebook3000.com)

Skin reactions, such as hives and rashes , are the most common type. (medlineplus.gov)
Bradycardia is a common adverse reaction with somatostatin analogues. (mims.com)
For many therapies administered intravenously, infusion reactions (IRs) are common, particularly among immunotherapeutics. (europa.eu)
The common, adverse drug reactions (side effects) are the same as with other PDE 5 inhibitors. (mdwiki.org)
The use of multiple drugs is common to increase the potential interaction. (bvsalud.org)
The most common problem for self-medicating was toothache, and the most frequent drug was Ibuprofen. (bvsalud.org)

In just little over a year, the HPV vaccine has been associated with at least five deaths, not to mention thousands of reports of adverse effects, hundreds deemed serious, and many that required hospitalization. (newswithviews.com)

Renz also provided evidence affirming that the Food and Drug Administration (FDA) has been using this same CMS data to monitor different types of adverse reactions to the injections in "near real time," even while these government agencies and the media continue to repeat that this gene-based vaccine is "safe and effective. (coronafraud.com)

Efficacy in monkey studies showed that the drug increased survival from 0 to 36 to 70%, and safety was tested in 74 healthy humans. (acpinternist.org)
Dietary supplements sleep aids have not been evaluated by the Food and Drug Administration for safety and efficacy. (wellnessdigest.com)

9.5% reported muscle-related side-effects such as myalgia. (who.int)

Intervene appropriately to minimize patient discomfort, reduce side effect progression, and ultimately support successful treatment completion. (cdc.gov)

Long-acting beta 2 -adrenergic agonists (LABA) increase the risk of asthma-related death. (rxlist.com)
A strengthened warning on ferumoxytol (Feraheme) about the risk of serious, potentially fatal allergic reactions . (acpinternist.org)
This may be due to differences in pharmacokinetics or levels of circulating hormones and/or more poly-pharmacy in women [11] or to a generally higher risk of drug-induced liver injury in women [12]. (janusinfo.se)
Increased risk of death in older adults with dementia-related psychosis. (healthline.com)
Older adults with psychosis related to dementia who are taking antipsychotics have an increased risk of dying. (healthline.com)
Older adults with dementia-related psychosis taking antipsychotics have also been shown to have a higher risk of stroke . (healthline.com)
Administration of antipsychotics appears to be related to increased risk of venous thromboembolism and cerebrovascular side effects. (nel.edu)
A safety review was carried out by Health Canada to evaluate the risk of bone-related side effects of using SGLT2 inhibitors. (canada.ca)
Recent medical studies have found an increased risk of losing bone mineral density and an increased risk of bone fracture occurring as early as 12 weeks of being on treatment with canagliflozin, but these side effects are still rare. (canada.ca)
Although, the clinical benefits outweigh the small risk of liver failure and myopathy, clinicians should be aware of the side-effects of statins. (who.int)
Others make it through, despite the side effects, when these are deemed of low enough risk or incidence. (europa.eu)
For some reason, the risk of drug interaction is completely ignored when it comes to the vaccinations. (newswithviews.com)
To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse, and misuse, the Food and Drug Administration (FDA) has required a Risk Evaluation and Mitigation Strategy (REMS) for these products. (nih.gov)
Alcoholics, recovering alcoholics and drug abusers should not take Zolpidem, because there is an increased risk of physical dependence. (sleepaidguide.com)

Your doctor or pharmacist can tell you more about the potential side effects of Latuda. (healthline.com)
To learn about other mild side effects, talk with your doctor or pharmacist, or read Latuda's Things to Know handout. (healthline.com)
Inform your doctor or pharmacist as soon as possible if any of these side effects persist or get worse. (rxgenericdb.com)
If you notice other effects not listed above, contact your doctor or pharmacist. (rxgenericdb.com)

lenvatinib is a topic covered in the Davis's Drug Guide . (drugguide.com)
Davis's Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. (drugguide.com)
We're glad you have enjoyed Davis's Drug Guide! (drugguide.com)
Want to regain access to Davis's Drug Guide? (drugguide.com)
pentamidine is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)

Programmatic Management of Drug-resistant Tuberculosis (PMDT) was jointly initiated in the Philippines in October 2000 by the private Makati Medical Center in Metro Manila and the Tropical Disease Foundation, Inc., in collaboration with the National TB Control Program and the local government unit, as the first directly observed therapy (DOTS)-plus pilot project for the management of MDR TB approved by the Green Light Committee ( 7 ). (cdc.gov)

While this is the most accurate information available at the time of publication, factors that may vary from year to year, such as local weather conditions, mosquito vector density, and prevalence of infection, can have a marked effect on local malaria transmission patterns. (cdc.gov)
In medical centers caring for large numbers of children with perinatally acquired HIV infection, PCP has been the initial HIV-related illness for 8%-12% of all children and for greater than 50% of those children who progress to AIDS within the first year of life (2-6). (cdc.gov)
In July 2015, the Philippines conducted a school-based mass drug administration using albendazole for soil-transmitted helminths infection. (who.int)

Discontinue use immediately if any allergic or other adverse reaction occurs. (nutriopack.com)

Increased cardiac output (positive inotropic effect) and slowing of the heart rate (negative chronotropic effect). (drugguide.com)

Vaccinia immune globulin intravenous (VIGIV) is recommended as the first line of therapy for treatment of adverse reactions resulting from continued vaccinia virus replication after vaccination using ACAM2000® or APSV . (cdc.gov)
Anthrax immune globulin intravenous (Anthrasil) to treat inhalational anthrax in combination with appropriate antibacterial drugs. (acpinternist.org)

However, this side effect may also be partly due to dehydration caused by the clenbuterol -like effects of the steroid if one's diet is not rich in fruits and vegetables, which provide natural electrolytes that aid in muscle function. (robertogiraldo.com)
Cardiff sports nutrition supply the finest sports nutrition, bodybuilding supplements and sports supplements from the biggest brands in the industry for proven, injectable steroid side effects. (marikaannecountouris.com)
Most people have steroid injections without any side effects. (marikaannecountouris.com)
Undoubtedly, adverse effects from epidural steroid injections are not usually lethal, but they can carry significant morbidity and may be. (marikaannecountouris.com)
Other forms of steroid drugs to produce serious side related to the inhibition of the aromatase enzyme or interaction with provide support for fat loss with cutting. (awnry.com)
Cortisone has many side effects: weight gain, fluid retention, osteoporosis in men and women, lowered immune system, slow wound healing, disturbances in sleep pattern, raise in blood sugar, raise in blood pressure, and steroid acne. (optimumhealthrehab.com)

Oxcarbazepine seems to be as potent as carbamazepine in the majority of studies comparing their efficacies in seizure disorders However, oxcarbazepine lacks the side effect of suppressing the immune system in the form of agranulocytosis (stopping the formation of granulocyte white blood cells). (dr-bob.org)
Lymph node swelling was seen in monkeys, but TeGenero stressed this was not a drug-related side effect and was simply evidence of the drug's expected effect on the immune system. (pharmatimes.com)
Biopuncture produces its clinical effects because it stimulates your immune system to restart its innate healing capacities. (optimumhealthrehab.com)

Xeljanz was approved by the Food and Drug Administration (FDA) in 2012 and is one of the most often prescribed drugs in its class. (verywellhealth.com)
A boxed warning is a serious warning from the Food and Drug Administration (FDA). (healthline.com)
On 18 October 2007, the U.S. Food and Drug Administration (FDA) announced that a warning about possible deafness ( sudden hearing loss ) would be added to the drug labels of vardenafil, and other PDE 5 inhibitors. (mdwiki.org)
These statements have not been evaluated by the Food and Drug Administration. (nutriopack.com)
The generics were approved by the US Food and Drug Administration in 2007. (sleepaidguide.com)
Look for the mandatory disclaimers on the label that these statements have not been evaluated by the Food and Drug Administration (FDA). (wellnessdigest.com)

In July, a whistleblower who works professionally as a computer programmer in health care data analytics, made a declaration under penalty of perjury that CMS data revealed "at least 45,000" vaccine-related deaths due to experimental COVID-19 vaccine injections. (coronafraud.com)
Adverse effects on joints following corticosteriod injections. (marikaannecountouris.com)
The effect Vermodje Decaver and harm ester is what controls administered through injections, while anavar is to be taken orally. (awnry.com)

The aim of the study was to determine incidence, features and outcomes of the adverse drug reactions (ADR) among emergency department (ED) visits of S. Giovanni Battista Hospital in Turin. (nih.gov)

However, the effect is reversible after treatment discontinuation [6, 14-17]. (janusinfo.se)
A number of studies have investigated the relationship between the time course of central nervous system dopamine and serotonin receptor blockade and plasma drug concentrations after the discontinuation of QTP treatment, and shown that the disappearance of QTP from plasma is much more rapid than the decrease in serotonin receptor occupancy [136,143, 145] . (researchgate.net)

Mild side effects of many drugs may go away within a few days or a couple of weeks. (healthline.com)
Side-effects of Diclofenac is usually mild and transient. (inceptapharma.com)

The book is divided into three parts: The first deals with global issues that affect the assessment and formulation of possible adverse effects, as well as with pertinent concepts related to basic pharmacology, physiology, and medical monitoring. (appi.org)
Antipsychotics, an association commonly used in psychiatric emergencies, alerting to the need to monitor the possible adverse effects of these drugs. (bvsalud.org)

Clavulanic acid is a β-lactam, structurally related to the penicillins, which possesses the ability to inactivate a wide range of β-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. (prescriptiondrugs.com)

Be aware of the prescribing-cascade treating an adverse drug reaction as an illness with another drug. (the-hospitalist.org)
These findings confirm the benefits of using the antiviral drug oseltamivir to treat flu illness and suggest that some children will benefit when treatment is initiated beyond 2 days, which is the recommended cut-off for treatment in the current package insert. (cdc.gov)
While CDC recommends flu vaccine as the first step to fight flu, antiviral drugs are a second line of defense that can be used to treat flu illness. (cdc.gov)
However, as noted in The Lancet Infectious Diseases study and other published studies, antiviral drugs can shorten the length of flu illness and virus shedding. (cdc.gov)

Post cycle therapy (pct) is a protocol that is started after completing a cycle of performance-enhancing drugs such as anabolic steroids and prohormones. (bluecrows.no)

These formulations may support occasional sleeplessness without causing adverse side effects. (wellnessdigest.com)

Anatomy1

Organisms10

Diseases66

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Psychiatry and Psychology3

Phenomena and Processes6

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture4

Humanities1

Information Science4

Named Groups2

Health Care25

Geographicals5

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (1/2245)

Use of ineffective or unsafe medications among members of a Medicare HMO compared to individuals in a Medicare fee-for-service program. (2/2245)

Is reporting rate a good predictor of risks associated with drugs? (3/2245)

Retrospective analysis of the frequency and recognition of adverse drug reactions by means of automatically recorded laboratory signals. (4/2245)

Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke. (5/2245)

Agranulocytosis in Bangkok, Thailand: a predominantly drug-induced disease with an unusually low incidence. Aplastic Anemia Study Group. (6/2245)

The lung in the immunocompromised patient. Infectious complications part 2. (7/2245)

A prospective study of adverse drug reactions in hospitalized children. (8/2245)

Drug-Related Side Effects and Adverse Reactions

Drug Hypersensitivity

Drug Eruptions

Adverse Drug Reaction Reporting Systems

Anaphylaxis

Diethylcarbamazine

Ivermectin

Filaricides

Product Surveillance, Postmarketing

Treatment Outcome

Double-Blind Method

Skin Diseases, Eczematous

HLA-B15 Antigen

Stevens-Johnson Syndrome

Annual Reports as Topic

Desensitization, Immunologic

Onchocerciasis

Pharmaceutic Aids

Drug Therapy, Combination

Nausea

Cosmetic Techniques

Administration, Oral

Food Hypersensitivity

Antivenins

Dose-Response Relationship, Drug

Clinical Trials as Topic

Nuclear Medicine

Time Factors

Pharmacovigilance

Urticaria

Drug Evaluation

Exanthema

Denture, Partial

Prospective Studies

Retrospective Studies

Vomiting

Drugs, Chinese Herbal

Drug Administration Schedule

Skin Diseases

Anti-Inflammatory Agents, Non-Steroidal

Extravasation of Diagnostic and Therapeutic Materials

Erythema

Albendazole

Eye Infections

Skin Tests

Safety

Administration, Topical

Snake Bites

Angioedema

Iodine Compounds

Gastrointestinal Diseases

Drug Interactions

Vaccination

Smallpox Vaccine

Drug Combinations

Infusions, Intravenous

Injections, Intravenous

Preservatives, Pharmaceutical

Gold Sodium Thiomalate

Trimethoprim-Sulfamethoxazole Combination

Fever

Psilocybine

Pruritus

Flushing

Immunoglobulins, Intravenous

Pallor

Bronchial Spasm

Sulfamethoxazole

Contrast Media

Placebos

Practolol

United States Food and Drug Administration

Carbamazepine

Elephantiasis, Filarial

Ointments

Antinematodal Agents

Anticonvulsants

Food Additives

Gout Suppressants

Follow-Up Studies