Drug-Related Side Effects and Adverse Reactions
Adverse Drug Reaction Reporting Systems
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Product Surveillance, Postmarketing
Skin Diseases, Eczematous
Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.
Drug Therapy, Combination
Dose-Response Relationship, Drug
Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Drugs, Chinese Herbal
Drug Administration Schedule
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Extravasation of Diagnostic and Therapeutic Materials
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)
Gold Sodium Thiomalate
A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
United States Food and Drug Administration
Substances which are of little or no nutritive value, but are used in the processing or storage of foods or animal feed, especially in the developed countries; includes ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS (both plain and LOCAL); VEHICLES; EXCIPIENTS and other similarly used substances. Many of the same substances are PHARMACEUTIC AIDS when added to pharmaceuticals rather than to foods.
Drug-Induced Liver Injury
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Radioactive substances added in minute amounts to the reacting elements or compounds in a chemical process and traced through the process by appropriate detection methods, e.g., Geiger counter. Compounds containing tracers are often said to be tagged or labeled. (Hawley's Condensed Chemical Dictionary, 12th ed)
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Skin Diseases, Vesiculobullous
Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)
Abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues. It refers almost exclusively to skin photosensitivity, including sunburn, reactions due to repeated prolonged exposure in the absence of photosensitizing factors, and reactions requiring photosensitizing factors such as photosensitizing agents and certain diseases. With restricted reference to skin tissue, it does not include photosensitivity of the eye to light, as in photophobia or photosensitive epilepsy.
A parasitic infection caused by the nematode Loa loa. The vector in the transmission of this infection is the horsefly (Tabanus) or the deerfly or mango fly (Chrysops). The larvae may be seen just beneath the skin or passing through the conjunctiva. Eye lesions are not uncommon. The disease is generally mild and painless.
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Vaccines used to prevent infection by viruses in the family ORTHOMYXOVIRIDAE. It includes both killed and attenuated vaccines. The composition of the vaccines is changed each year in response to antigenic shifts and changes in prevalence of influenza virus strains. The vaccine is usually bivalent or trivalent, containing one or two INFLUENZAVIRUS A strains and one INFLUENZAVIRUS B strain.
Medicine, Chinese Traditional
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Randomized Controlled Trials as Topic
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
A republic stretching from the Indian Ocean east to New Guinea, comprising six main islands: Java, Sumatra, Bali, Kalimantan (the Indonesian portion of the island of Borneo), Sulawesi (formerly known as the Celebes) and Irian Jaya (the western part of New Guinea). Its capital is Djakarta. The ethnic groups living there are largely Chinese, Arab, Eurasian, Indian, and Pakistani; 85% of the peoples are of the Islamic faith.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.
A republic in the Greater Antilles in the West Indies. Its capital is Port-au-Prince. With the Dominican Republic it forms the island of Hispaniola - Haiti occupying the western third and the Dominican Republic, the eastern two thirds. Haiti belonged to France from 1697 until its rule was challenged by slave insurrections from 1791. It became a republic in 1820. It was virtually an American protectorate from 1915 to 1934. It adopted its present constitution in 1964 and amended it in 1971. The name may represent either of two Caribbean words, haiti, mountain land, or jhaiti, nest. (From Webster's New Geographical Dictionary, 1988, p481 & Room, Brewer's Dictionary of Names, 1992, p225)
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.
Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.
A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.
Yellow Fever Vaccine
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Central Nervous System Diseases
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Various forms of chemically induced liver injury and their detection by diagnostic procedures. (1/2245)A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to the drug or a metabolic aberation of the host permitting the accumulation of hepatotoxic metabolites. The syndromes of hepatic disease produced by drugs have been classified hepatocellular, hepatocanalicular, mixed and canalicular. Measurement of serum enzyme activities has provided a powerful tool for studies of hepatotoxicity. Their measurement requires awareness of relative specificity, knowledge of the mechanisms involved, and knowledge of the relationship between known hepatotoxic states and elevated enzyme activities. (+info)
Use of ineffective or unsafe medications among members of a Medicare HMO compared to individuals in a Medicare fee-for-service program. (2/2245)Adverse drug reactions and inappropriate prescribing practices are an important cause of hospitalization, morbidity, and mortality in the elderly. This study compares prescribing practices within a Medicare risk contract health maintenance organization (HMO) in 1993 and 1994 with prescribing practices for two nationally representative samples of elderly individuals predominantly receiving medical care within the Medicare fee-for-service sector. Information on prescriptions in the fee-for-service sector came from the 1987 National Medical Expenditures Survey (NMES) and the 1992 Medicare Current Beneficiary Survey (MCBS). A total of 20 drugs were studied; these drugs were deemed inappropriate for the elderly because their risk of causing adverse events exceeded their health benefits, according to a consensus panel of experts in geriatrics and pharmacology. One or more of the 20 potentially inappropriate drugs was prescribed to 11.53% of the Medicare HMO members in 1994. These medications were prescribed significantly less often to HMO members in 1994 than to individuals in the fee-for-service sector, based on information from both the 1987 NMES and the 1992 MCBS. Utilization of unsafe or ineffective medications actually decreased with increasing age in the HMO sample, with lowest rates in individuals over the age of 85. However, no relationship between age and medication use was seen in the NMES study, except for individuals over the age of 90 years. The study data support the conclusion that ineffective or unsafe medications were prescribed less often in the Medicare HMO than in national comparison groups. In fact, for the very old, who are most at risk, the use of these medications was much lower in the Medicare HMO than in the Medicare fee-for-service sector. Nevertheless, in 1994, approximately one of every nine members of this Medicare HMO received at least one such medication. Continued efforts and innovative strategies to further reduce the use of unsafe and ineffective drugs among elderly Medicare HMO members are needed. (+info)
Is reporting rate a good predictor of risks associated with drugs? (3/2245)AIMS: Uncertainty as to relative under-reporting plagues the comparisons of spontaneous reporting rates as a tool for decision-making in pharmacovigilance. However, it is generally accepted that under-reporting should be reasonably similar for similar drugs sharing the same indication, country and period of marketing. To test this, we compared the adverse drug reaction reporting rates to the French regional pharmacovigilance centres for six pairs of identical drug marketed at the same time by different companies under different brand names (co-marketing). METHODS: All reaction reports were related to sales, to compute reporting rate; within each pair, the reporting rate ratio and its confidence interval were calculated. RESULTS: The rate ratios were all between 0.76 and 1.33. Two of them were significantly different from 1 (1.28; 95% C.I. [1.01; 1.60] and 1.33; 95% C.I. [1.06; 1.74]). CONCLUSIONS: These small differences in reporting rates would not warrant regulatory action and support the usual assumption of similar reporting for similar drugs. (+info)
Retrospective analysis of the frequency and recognition of adverse drug reactions by means of automatically recorded laboratory signals. (4/2245)AIMS: To estimate the frequency of adverse drug reactions (ADRs) identified through the use of automatic signals generated from laboratory data (ALS) in hospitalised patients. To determine the frequency of spontaneous recognition of these ADRs by the attending physicians and to assess the potential value of ALS for detection of ADRs. METHODS: Laboratory results of patients hospitalised in a nine bed medical ward were automatically recorded over a period of 17 months. Values exceeding defined boundaries were used as ALS. Charts of every third patient were analysed retrospectively with regard to adverse drug related reactions and causality was evaluated as well as whether the ADR had been recognised during the period of hospitalisation. RESULTS: The charts and ALS of 98 patients were analysed. In 18 cases a drug-related adverse reaction was probable. Awareness to the reaction by the treating physicians was evident in 6 out of these 18 ADRs. Approximately 80% of the ADRs were considered predictable. Three ADRs were regarded as serious. CONCLUSIONS: Adverse drug reactions are common and often preventable. Only one third of ADRs which could have been detected through ALS were recognised by the attending physicians. An increased doctor's awareness of the frequency of drug related abnormal laboratory results by means of ALS is likely to increase the recognition rate of ADRs and might help to prevent them. (+info)
Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke. (5/2245)AIMS: To estimate the incidence of newly diagnosed idiopathic stroke among users of fenfluramine, dexfenfluramine and phentermine compared to obese nonusers. METHODS: We conducted a cohort study with nested case-control analysis utilizing data from the General Practice Research Database in the UK. Eight thousand four hundred and twenty-three subjects aged 69 years or less at the start of follow-up were exposed to at least one of the three study drugs and 17 225 similarly obese subjects were not exposed to any of the study drugs. RESULTS: We identified 45 incident cases of idiopathic CVA in this cohort of subjects. The incidence of CVA among all current users of a diet drug was 1.3/1000 person-years (95% CI 0.5, 3.5). The incidence for current fenfluramine users (n=2) was 2.6/1000 person-years (95% CI 0.7, 9.6), for current dexfenfluramine users (n=1) 1.1/1000 person-years (95% CI 0.3, 3.8), and for current phentermine users 0/1000 person-years (95% CI 0.0, 12.9). The incidence in obese nonusers was 0.6/1000 person-years (95% CI 0.4, 0. 9). The adjusted matched odds ratio (OR) for thrombotic stroke from the case-control analysis comparing current use of a diet drug to nonuse was 2.4 (95% CI 0.6, 9.1). There was only one exposed subject among seven who had haemorrhagic stroke. CONCLUSIONS: The incidence of CVA in generally young obese subjects during use of fenfluramine, dexfenfluramine or phentermine is low. Although we found an OR of 2. 4 comparing users of any of the anorexiants with nonusers, this is based on only three exposed cases and the confidence limits are wide. We conclude that our study does not support a substantial increased risk of stroke attributable to the use of fenfluramine, dexfenfluramine or phentermine. (+info)
Agranulocytosis in Bangkok, Thailand: a predominantly drug-induced disease with an unusually low incidence. Aplastic Anemia Study Group. (6/2245)Agranulocytosis, a syndrome characterized by a marked reduction in circulating granulocytes, is strongly associated with medical drug use in Europe and the United States. Unregulated use of common pharmaceutical agents in developing countries has been suspected of causing large numbers of cases of agranulocytosis and deaths, especially among children. To elucidate the incidence and etiology of agranulocytosis in Thailand, a population-based case-control study of symptomatic agranulocytosis that resulted in hospital admission was conducted in Bangkok from 1990 to 1994. An attempt was also made to study the disease in Khonkaen (in northeastern Thailand) and Songkla (in southern Thailand), but there were insufficient cases in the latter regions, and the analysis was confined to subjects from Bangkok. In that region, the overall incidence of agranulocytosis was 0.8 per million per year; there were no deaths. As expected, the incidence was higher in females (0.9 per million), and it increased with age (4.3 per million beyond age 60). Among 25 cases and 529 controls the relative risk estimate for a combined category of all suspect drugs was 9.2 (95% confidence interval = 3.9-21), and the proportion of cases that could be attributed to drug use was 68%. For individual drugs and drug classes the data were sparse; within these limitations, the strongest association appeared to be with antithyroid drugs. One case and three controls were exposed to dipyrone, a drug known to cause agranulocytosis; with such scanty data the risk could not be evaluated. Exposure to pesticides or solvents was not associated with an increased risk. This is the first formal epidemiologic study of agranulocytosis in a developing country. As in the West, most cases are attributable to medical drug use. However, the incidence of agranulocytosis in Bangkok, and apparently, in Thailand as a whole, is unusually low, and the disease does not pose a public health risk. (+info)
The lung in the immunocompromised patient. Infectious complications part 2. (7/2245)Pulmonary infections decisively contribute to morbidity and mortality in immunocompromised patients. Bacterial, mycobacterial and infections with Pneumocystis carinii have been reviewed in an article in the last issue of Respiration. In this review, viral and fungal pulmonary infections are discussed in HIV-positive patients and in patients treated with high-dose chemotherapy, stem cell or solid-organ transplantation. (+info)
A prospective study of adverse drug reactions in hospitalized children. (8/2245)AIMS: There are few publications of adverse drug reactions (ADRs) among paediatric patients, though ADR incidence is usually stated to be higher during the first year of life and in male patients. We have carried out a prospective study to assess the extent, pattern and profile risk for ADRs in hospitalized patients between 1 and 24 months of age. METHODS: An intensive events monitoring scheme was used. A total of 512 successive admissions to two medical paediatric wards (47 beds) were analysed. The hospital records were screened daily during two periods (summer, 105 days and winter, 99 days), and adverse clinical events observed were recorded. RESULTS: A total of 282 events were detected; of these, 112 were considered to be manifestations of ADRs. The cumulative incidence was 16.6%, no differences being observed between periods. Although there were no differences between patients under and over 12 months of age, risk was found to be significantly higher among girls compared with boys (RR=1.66, 95% CI 1.03-2.52). The gastro-intestinal system was most frequently affected. The therapeutic group most commonly implicated was anti-infective drugs and vaccines (41.5%). The ADRs were mild or moderate in over 90% of cases. A consistent relationship was noted between the number of drugs administered and the incidence of ADRs. CONCLUSIONS: Hospitalized patients exhibited an ADR risk profile that included female sex and the number of drugs administered. No particular age predisposition was observed. The most commonly prescribed drugs are those most often implicated in ADRs in paediatric patients. (+info)
Pioglitazone/Glimepiride (Sonias) Combination Tablets Special Drug Use Surveillance Survey in Patients With Type 2 Diabetes...
Frequency of serious adverse drug reactions is defined at the number of participants with serious adverse drug reactions. Frequency of serious adverse drug reactions were tabulated by each symptom. Adverse events are defined as any unfavorable and unintended signs, symptoms or diseases temporally associated with the use of a medicinal product reported from the first dose of study drug to the last dose of study drug. A serious adverse event is any experience that suggests a significant hazard, contraindication, side effect or precaution that: results in death, is life-threatening, required in-patient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital anomaly/birth defect or is medically significant. Among these, events which are considered possibly associated with a medicinal product are defined as adverse drug reactions ...
A Recommender System Approach for Predicting Drug Side Effects - Research - Royal Holloway, University of London
The accurate identification of drug side effects represents a major concern for public health. We propose a collaborative filtering model for large-scale prediction of drug side effects. Our approach provides specific recommendations for side effects of medicines. The proposed latent factor model relies solely on the public drug-side effect relationships from safety data. Applied to 1,525 marketed drugs and 2,050 side effects, we achieved an AUPRC (area under the precision-recall curve) of 0.342 in a hold-out test set, with a sensitivity of 0.73 given a specificity of 0.95, providing state-of-the-art performance in ...
Party drugs side effects Effects, Legal Party Pills - July 22, 2017
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drug side effects - Magnesium and Health
This is part two (see part 1 here) of an ongoing article about overmedication by drug pushing doctors, drug side effects and Big Pharma who seem to be at the hub of almost anything to do with health and not in a good way. Big Pharmas corruption is having a knock on effect across the whole of the medical fraternity and the public need to stop being so trusting and start asking questions! Continue reading Drug Side Effects - Trust me Im a doctor! →. ...
Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis. | Systems...
Drug side effects cause a significant clinical and economic burden. However, mechanisms of drug action underlying side effect pathogenesis remain largely unknown. Here, we integrate pharmacogenomic and clinical data with a human metabolic network and find that non-pharmacokinetic metabolic pathways dysregulated by drugs are linked to the development of side effects. We show such dysregulated metabolic pathways contain genes with sequence variants affecting side effect incidence, play established roles in pathophysiology, have significantly altered activity in corresponding diseases, are susceptible to metabolic inhibitors and are effective targets for therapeutic nutrient supplementation. Our results indicate that metabolic dysregulation represents a common mechanism underlying side effect pathogenesis that is distinct from the role of metabolism in drug clearance. We suggest that elucidating the relationships between the cellular response to drugs, genetic variation of patients and cell ...
Aciphex prescription drug side effect - Herbal Health Supplements - May 19, 2017
Aciphex prescription drug side effect - Aciphex Side Effects, Information and Pricing - GoodRx. We provides discount Herbal health and beauty products made in USA. Find on-line health supplements and Herbal beauty products here.
Drug Side Effects and Drug Interactions Flashcards - Cram.com
Study Flashcards On Drug Side Effects and Drug Interactions at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Drug Side Effect and Prescription Error Claims - JMW Solicitors
Our expert solicitors can help you make a successful claim if you have suffered due to a prescription error, including drug side effects. Contact JMW today.
Adverse Drug Effect - Pharma Diagnosis
Adverse Drug Effect - Definition, Classifications, Severity of Adverse Drug Reactions, Prevention of Adverse Effects to Drugs, Pharmacovigilance information.
Adverse Drug Effects, Medication Errors, and Medication Safety
Adverse Drug Effects, Medication Errors, and Medication Safety - All medical errors are preventable, and not all medical errors are harmful. Have you,
Adverse Drug Effects, Medication Errors, and Medication Safety
Adverse Drug Effects, Medication Errors, and Medication Safety - All medical errors are preventable, and not all medical errors are harmful. Have you,
adverse drug effect Archives | The Saturday Evening Post
William Osler. We live in an era of polypharmacy. Many people, particularly the elderly, ingest five or more drugs daily for a multitude of common problems such as high blood pressure, arthritis pain, depression, diabetes, and so on. Most of these drugs, when prescribed and carefully monitored by a physician, help relieve symptoms, and some are even lifesaving. However, unintended consequences can cause important side effects.. The greatest risk factor for adverse drug-related events is the number of drugs prescribed. For example, the risk of an adverse drug effect is 50 to 60 percent if four drugs are taken chronically, and almost 100 percent with eight or nine drugs.. It is critical that patients review their entire drug list, including dietary supplements, at each visit with their physician or pharmacist. Often, a physicians role is to educate patients about what drugs not to take, and to de-prescribe drugs rather than add more. A general recommendation for the patient is to take a drug for ...
Reports of Adverse Drug Effects Up
Reports of adverse drug effects reported to the U.S. Food and Drug Administration (FDA) more than doubled in the last decade, according to a new study.
Drug Side Effects
By Lita Lee, Ph.D.The toxic side effects of drugs Drugs control the body and have toxic side effects. Food allows the body to nourish and heal itself. Which do you prefer? Drugs are unidirectional and always lower your blood chem values. For example, insulin ONLY lowers blood glucose. It cannot raise it back to normal. Appropriately used drugs have saved lives in cases where nothing else could have intervened but in many cases, a nutritional approach can bring about self-healing without the toxic side effects of drugs.. This article describes certain drugs and their side effects and provides non-toxic alternatives for headaches, candidiasis, anxiety, panic and insomnia.
unexpected side effects
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Drug Side Effects Articles - Page 71 of 71 - The Peoples Pharmacy
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The Peoples Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as one of the countrys leading drug experts for the consumer. Read 's Full Bio ...
A unified frame of predicting side effects of drugs by using linear neighborhood similarity | BMC Systems Biology | Full Text
Drug side effects are one of main concerns in the drug discovery, which gains wide attentions. Investigating drug side effects is of great importance, and the computational prediction can help to guide wet experiments. As far as we known, a great number of computational methods have been proposed for the side effect predictions. The assumption that similar drugs may induce same side effects is usually employed for modeling, and how to calculate the drug-drug similarity is critical in the side effect predictions. In this paper, we present a novel measure of drug-drug similarity named
FDA Targets Drug Side Effects
The Food and Drug Administration (FDA) is working on many fronts to expect the unexpected when it comes to medication side effects.. FDA wants to strengthen researchers ability to detect chemical or biological substances that could be life-threatening, or even fatal, before products containing them hit the market.. All drugs have side effects, says FDAs Vicki Seyfert-Margolis, Ph.D., senior advisor for science innovation and policy. The goal is to predict side effects earlier and better to help ensure that patients avoid them altogether.. COX-2 inhibitors-anti-inflammatory drugs designed to ease arthritis pain while protecting the stomach and intestines-are a good example of popular medicines that had unforeseen complications, says Douglas Throckmorton, M.D., deputy director of FDAs Center for Drug Evaluation and Research.. These drugs were found to increase the risk of heart attack and stroke. The drugs Vioxx and Bextra were withdrawn from the market in 2004 and 2005 respectively. FDA ...
Down the Rabbit Hole of Pharmaceutical Ethics: Profiting from Drug Side Effects | Deadly Prescription
The Motley Fool finance and investing website (Fool.com) reported on December 3rd, 2015 that Foamix Pharmaceuticals stock was up about 10% after releasing positive results from its phase 2 clinical study of FDX104. The article headline exemplifies a certain insensitivity to patients when it comes to pharmaceuticals and money: Foamix Pharmaceuticals Ltd Hopes to Profit from Eli Lillys and Amgens Side Effect. FDX104 is designed to prevent moderate-to-severe skin rashes in patients treated with the epidermal growth factor receptor antibody inhibitors (EGFRI), such as Eli Lillys Erbitux and Amgens Vectibix, said the article. The rash, while not as life threatening as the cancer that Eli Lillys and Amgens drugs are designated to treat, can get so bad that doctors need to reduce the dose or even discontinue the treatment altogether, added Fool.com. The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular
References Alexopoulos CG, Rachiotis G, Valassi M, Drivas | miRNA
References Alexopoulos CG, Rachiotis G, Valassi M, Drivas selleck kinase inhibitor S, Behrakis P (2005) Under-registration of occupational diseases: the Greek case. Occup Med (Lond) 55.1:64-65 Azaroff LS, Levenstein C, Wegman DH (2002) Occupational injury and illness surveillance: conceptual filters explain underreporting. Am J Public Health 92(9):1421-1429CrossRef Bäckström M, Mjörndal T (2006) A small economic inducement to stimulate increased reporting of adverse drug reactions-a way of dealing with an old problem? Eur J Clin Pharmacol 62(5):381-385CrossRef Bäckström M, Mjörndal. T, Dahlqvist R (2004) Under-reporting of serious adverse drug reactions in Sweden. Fludarabine mouse Pharmacoepidemiol Drug Saf 13(7):483-487CrossRef Biddle J, Roberts K, Rosenman KD, Welch EM (1998) What percentage of workers with work-related illnesses receive workers compensation benefits? J Occup Environ Med 40.4:325-331 Blandin MC, Kieffer C, Lecoanet C (2002) KCLC. Occupational diseases in 15 European ...
Problems With HIV Drug Side Effects? Try Acupuncture | Neuropathy and HIV
Todays post from pacificcollege.edu (see link below) is a general article about the benefits of acupuncture for relieving the side effects of HIV combination drugs. It also specifically references neuropathy which may be of interest to regular readers. Many younger people, especially in the West, where HIV drugs have been significantly refined to reduce side effects considerably over the last few years, may well shrug their shoulders here and say that they have no side effect issues from combination therapy. However, the vast majority of people across the world who are living with HIV havent achieved that luxury yet. They have to remain on older drug combinations because of resistance issues if they change, or non-availability and they may well have been living with side effects for so long that its become part of their daily lives. In these cases, this article may be of value. It is important to consult a qualified acupuncturist who knows what he/she is doing and although it is relatively ...
The Other Side of Town.......: PSA: Cholesterol drug side effects
Every now and then Side has a personal experience we feel is worthy of passing along to our readers. Weve had one of real significance recently, and we want you to know about it. Rather than blather (were poets!) on about the background, suffice it to say we had sufficient cause to look into the side effects of the statin drugs so commonly prescribed these days. Weve been on one for five years, prescribed not because we had high cholesterol, but because we reached the age of 70. Thats the current guidance in the doctoring world.. Over the last several years, we began to notice stiffness and aching, especially in our legs, and have been very unhappy about it. It never dawned on us that this could be a drug side-effect; we simply assumed it was a consequence of growing old and being vertical.. Heres a slightly edited version of the email we sent to friends and family on the subject. At the very least, we suggest you do your own thinking and follow up research if you or someone you know is ...
psychiatric drug side effects - Dr Darvin Hege
Statistics of Sexual Dysfunction. Most of the research available on impaired sexual function and psychiatric medication focus primarily on depression and antidepressants. Sexual dysfunction however is also a concern for those diagnosed with anxiety disorders, mood disorders, bipolar disorder, and schizophrenia to name a few. While 35% to 50% of those with untreated major depression report some type of sexual issue, those taking SSRIs (anti-depressant medication) report 30% to 40% delayed orgasm, 20% report decreased libido, and 10% of men complain of erectile function.. Impact of Psychiatric Medications on Sexual Function. The following classes of medication listed indicate some common drugs within each class that have more reported sexual side effects versus those with fewer reported sexual side effects:. Antidepressants:. ...
Carac, Efudex, Efudex Occlusion Pack, Fluoroplex (fluorouracil topical) Drug Side Effects, Interactions, and Medication...
Drug information on Carac, Efudex, Efudex Occlusion Pack, Fluoroplex (fluorouracil topical), includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid.
Palmitoylethanolamide for the treatment of pain : pharmacokinetics, safety and efficacy
Palmitoylethanolamide (PEA) has been suggested to have useful analgesic properties and to be devoid of unwanted effects. Here, we have examined critically this contention, and discussed available data concerning the pharmacokinetics of PEA and its formulation. Sixteen clinical trials, six case reports/pilot studies and a meta-analysis of PEA as an analgesic have been published in the literature. For treatment times up to 49days, the current clinical data argue against serious adverse drug reactions (ADRs) at an incidence of 1/200 or greater. For treatment lasting more than 60days, the number of patients is insufficient to rule out a frequency of ADRs of less than 1/100. The six published randomized clinical trials are of variable quality. Presentation of data without information on data spread and nonreporting of data at times other than the final measurement were among issues that were identified. Further, there are no head-to-head clinical comparisons of unmicronized vs. micronized ...
Triglycerides Drugs Side Effects
Trilipix side effects range from minor symptoms like constipation, diarrhea and heartburn, to pain in the back, arms and legs. You may also get persistent headaches. The more serious side effects are: weakness, muscle pain or tenderness, joint pain and fever. There is also rash on skin, and painful back to worry about. Should you feel any of these symptoms, contact your doctor immediately. Triglycerides drugs are only a part of the combination for keeping your heart and circulatory system healthy. A triglyceride diet plan is the key to preventing heart disease, especially if the risk factors deserve preventive measures. Triglycerides are found in dairy products, foods high in saturated fats, particularly organ meats like liver, kidneys and hearts. Therefore, minimizing the consumption of these types of foods will help you to get off to a good start. Eating plenty of fresh fruit and vegetables, along with exercising for at least 30 minutes a day will help you to get even more use out of your ...
Internet Searches Provide Data on Drug Side Effects | Addiction Prevention Coalition
Scientists can use data from Internet searches to learn about unreported side effects from prescription drugs, before they are found by the Food and D...
Xconomy: AdverseEvents.com Seeks to Keep Track of Drug Side Effects the Way the FDA Never Could
Some powerful people in the pharmaceutical industry would like to see Brian Overstreet and his startup fall flat. Big pharma companies, on a few occasions,
GoGuides Topic: Health & Fitness | Drugsdb.com - Drug Side Effects Database
Provides consumer health information on the side effects of the Top 1,000 prescription and over-the-counter drugs and medications.
anakinra (Kineret): Arthritis Drug Side Effects & Dosage
anakinra (Kineret) is an arthritis drug prescribed to treat rheumatoid arthritis over 18 years of age. Side effects, drug interactions, storage and dosing information, and pregnancy safety information is provided.
Biotin Supplements Can Help Counteract Epilepsy Drug Side Effects and Reduce Seizures
Epilepsy drugs can cause biotin deficiency. Side effects from depleted biotin are reduced with supplementation, which may also lower the frequency of seizures.
Nitrolingual, Nitrolingual Duo Pack, Nitromist, Nitrostat, Nitro-Time (nitroglycerin (oral/sublingual)) Drug Side Effects,...
Drug information on Nitrolingual, Nitrolingual Duo Pack, Nitromist, Nitrostat, Nitro-Time (nitroglycerin (oral/sublingual)), includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid.
Using nanoparticles to lessen prostate cancer drug side effects | FiercePharma
Nanotech researchers are again showing that cancer drugs delivered via nanoparticles can reduce unpleasant and painful side effects. Researchers at MIT and Brigham and Womens Hospital say they can
naproxen | Psychiatric Drugs | Antidepressants | Antipsychotics | Antimanic | Drugs | Side Effects
Read the Medication Guide that comes with PEXEVA before you start taking it and each time you get a refill. There may be new information. This Medication Guide does not take …. ...
Hospitals clueless about drug side effects - The Local
Despite tens of thousands of patients coming down with diseases caused by medications theyre taking, awareness of the problem remains low at Swedens emergency hospitals, according to a recent report.
Kalydeco Vertex Drug Side Effects and Dos & Donts | Health Side Effects
Breakthrough drug Kalydeco targets faulty protein to treat rare form of cystic fibrosis . A drug that targets the underlying cause of a rare form of cystic…
Fluoroquinolones - Antibacterial Drug Side Effects
Learn about fluoroquinolone side effects, including tendonitis. Find an attorney to help you gain compensation if harmed by these defective drugs.
migraines | Psychiatric Drugs | Antidepressants | Antipsychotics | Antimanic | Drugs | Side Effects
Read the Medication Guide that comes with PAXIL CR before you start taking it and each time you get a refill. There may be new information. This …. ...
Stroke patients ignoring GP advice because of drug side effects | Harrogate Advertiser
Given the variety of cholesterol lowering treatments and possible approaches to manage statin intolerant patients, I was surprised to see that patients seemingly lost hope after only one or two contacts with their GPs, unaware that a better regimen may have been available or that their GP would have been able to carry out another change in medication. ...
More on Predicting Serious Drug Side Effects Before They Occur
From common aspirin to herbal remedies and from standard anticancer drugs to experimental immunosuppressants, all medicines have side-effects.
Other Dangerous Drugs - Side Effects | Thomas J. Henry
If you or a loved one have been severely injured after taking a dangerous medication, contact our experienced drug recall lawyers for a free case review.
Drugs side effects in lungs more widespread than thought | EurekAlert! Science News
A systematic review of research has revealed that the toxic effects on the lung of drugs commonly taken to treat a range of common conditions is much more widespread than thought.
Can I Maintain Myeloma Remission Without Drug Side Effects? - Multiple Myeloma Center - Everyday Health
I felt protected by taking maintenance therapy for myeloma, but the neuropathy was very bad. Are there any other effective maintenance treatments?
JaypeeDigital | Handbook on Adverse Drug Reactions in TB Treatment
This handbook focuses on adverse drug reactions in tuberculosis treatment. Tuberculosis is a multisystem disease with varied clinical presentations. One-third of the worlds population is infected with Mycobacterium tuberculosis and there is 10% lifetime risk of developing tuberculosis and the risk further increases to 10% annual risk in immunocompromised patients. This book is written with the aim of defining a practical approach to every aspect of adverse drug reaction in tuberculosis treatment. In total, there are 21 chapters in the book. Chapters practically cover all the aspects of adverse drug reaction in TB treatment ranging from pharmacology, interaction between anti-TB drugs with food and other drugs including antiretroviral drugs, monitoring and management of adverse drug reaction of antituberculosis used in new and drug-resistant cases of tuberculosis. Special chapters on case-based approach to treatment of tuberculosis and MDR-TB and XDR-TB in special situation like pregnancy, renal
Trends in hospital admissions for adverse drug reactions in England: analysis of national hospital episode statistics 1998-2005...
Adverse drug reactions cause considerable morbidity and mortality world-wide  and in many cases are avoidable. Pirmohamed and colleagues estimated that in England, adverse drug reactions were responsible for around 6.5% of all acute hospital admissions and at least 5,000 deaths per year . In the USA, adverse drug reactions are one of the leading causes of death in the population . Hence, adverse drug reactions have a major impact on public health, reducing patients quality of life and imposing a considerable financial burden on the health care systems at a time when many health care systems are under considerable financial strain.. Drug reactions can be typically described in two groups. Type A reactions intrinsic (which are often dose-dependent) are relatively common. Type B reactions are usually more serious: idiosyncratic reactions that are not necessarily dose-dependent. We expect the majority of ADR admissions to be Type A reactions. Notification to pharmacovigilance agencies ...
How patient reporters identify adverse drug reactions: a qualitative study of reporting via the UK Yellow Card Scheme.<...
TY - JOUR. T1 - How patient reporters identify adverse drug reactions. T2 - a qualitative study of reporting via the UK Yellow Card Scheme.. AU - Krska, Janet. AU - Anderson, Claire. AU - Avery, Anthony. AU - Watson, Mags. AU - on behalf of the Yellow Card Study Collaboration (including Watson MC. AU - Lee, Amanda Jane. AU - Murphy, Elizabeth. PY - 2011/5/1. Y1 - 2011/5/1. N2 - Direct reporting of suspected adverse drug reactions (ADRs) to authorities is increasing, but questions remain about how patients identify suspected ADRs and their ability to distinguish between ADRs and other symptoms. OBJECTIVE: The aim of the study was to determine how reporters to the Yellow Card Scheme (YCS) identify ADRs. METHODS: We carried out a qualitative analysis of data from three sources, obtained as part of a larger evaluation of patient reporting to the UK YCS: responses to open questions in postal questionnaires sent to all reporters during March 2008-January 2009 (method 1); telephone interviews with a ...
Consequences, measurement, and evaluation of the costs associated with adverse drug reactions among hospitalized patients in...
Adverse drug reactions (ADRs) are a leading cause of morbidity in developed countries and represent a substantial burden on health-care resources. Many countries spent 15% to 20% of their hospital budgets to treat drug complications. However, few studies have measured the pharmacoeconomic effects of ADRs on hospitalized patients in China. The study estimates the costs of ADRs as identified from the spontaneous voluntary reports completed from healthcare professionals. To do so, we calculate these costs, determine the sum of Medicare payments and their proportion of total healthcare spending, and evaluate the incidence of ADRs, characteristics of hospitalized ADR patients, and outcomes of ADRs in China. This retrospective survey studied patients who experienced ADRs during their hospitalization at a Chinese tertiary-care teaching hospital. The patients were divided into group A and group B according to general ADRs and serious ADRs in Provisions for Adverse Drug Reaction Monitoring and Reporting. The
Adverse Drug Reactions: 196 (Handbook of Experimental by Jack Uetrecht - Three Classicists Library
This e-book presents the present kingdom of information of simple mechanisms of difficult drug reactions (ADRs). the main target is on idiosyncratic drug reactions simply because theyre the main tricky to accommodate. It starts off with a basic description of the foremost goals for ADRs by way of an outline of what are shortly believed to be mediators and biochemical pathways fascinated with idiosyncratic drug reactions. theres additionally an outline of numerous examples of ADRs that serve to demonstrate particular features of ADR mechanisms. finally the ebook exhibits that eventually larger tools are had to expect which drug applicants are inclined to reason ADRs and which sufferers are at elevated danger. yet at the present study appears to be like faraway from this goal. ...
Pharmacogenetics and Anesthetic Drugs | BenthamScience
Title:Pharmacogenetics and Anesthetic Drugs. VOLUME: 7 ISSUE: 2. Author(s):Vidya Chidambaran, Pornswan Ngamprasertwong, Alexander A. Vinks and Senthilkumar Sadhasivam. Keywords:Anesthesia, genetics, personalized medicine, pharmacogenetics. Abstract:The incidence and potential for serious adverse drug reactions (SADRs) in anesthesia are high due to the narrow therapeutic indices of anesthetic and analgesic drugs and high interindividual variability in drug responses. Genetic factors contribute to a majority of these SADRs. Pharmacogenetics (PG), the study of genetic effects on drug action, is strongly related to the field of anesthesia; historically, succinylcholine apnea and malignant hyperthermia were among the first PG disorders reported. Recent years have strengthened this affiliation with an emerging wide base of knowledge of the effects of genetic variations on the pharmacodynamics and pharmacokinetics of anesthetic drugs. Here, we review the history of anesthetic PG, the important genes ...
clindamycin, Oral (Cleocin): Drug Side Effects, Dosage
Consumer information about the oral medication clindamycin (Cleocin) side effects, drug interactions, recommended dosages, and storage information. Read more about the oral prescription drug clindamycin (Cleocin).
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Tocotrienols in Combat: Fighting the Statin Damage Crisis | WholeFoods Magazine
Annato plant, a source of tocopherol-free tocotrienol.. When I lost my short-term memory six weeks after starting Lipitor, I immediately suspected my new medicine and discontinued the drug. At my next NASA physical, I was urged to resume taking it and reluctantly agreed, only to suffer a much worse memory loss a few weeks later. For 12 hours, I suddenly became a teenager with total recall for my high school days, but absolutely no awareness that I was a doctor, married with children and a former NASA astronaut. This began my decade of research on the subject.. To my amazement, I discovered an extraordinary lack of information in my own medical community as to the true spectrum of statin drug side effects. I started a Web site (www.spacedoc.com), which has become a major message board and resource for those with statin drug-associated side effects. My four books-Lipitor, Thief of Memory, Statin Drug Side Effects, Statin Damage Crisis and The Dark Side of Statins-present the reasons for adverse ...
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Long Term Effects of Spice Abuse | Spice Drug Side Effects
Find out what the long term effects of spice abuse are and how you can get help for an addiction. Call us today at (877) 855-3470 to get help.
Observational Safety Study in Subjects Using Levemir (Insulin Detemir) for the Treatment of Type 2 Diabetes Mellitus -...
The aim of this observational study is to evaluate the incidence of serious adverse drug reactions while using insulin detemir under normal clinical practice
medication-related visits | Physicians Weekly for Medical News, Journals & Articles
by PWeekly , Oct 24, 2016. Physicians Weekly talked with Peter J. Zed, BSc, BSc (Pharm), ACPR, PharmD, FCSHP, and Neil J. MacKinnon, PhD, FCSHP, about their recent study that found that about one of every 12 emergency department (ED) visits by pediatric patients is medication related. PW: What makes medication-related pediatric ED visits an important topic to study? PZ: Adverse drug events and patient safety in healthcare have come to the forefront in the last decade. Much of the work on adverse drug events and patient safety has been conducted in adults and pediatric patients are often under-represented or excluded from this work. As a result, there are gaps in the literature surrounding the understanding of the impact of adverse drug events in pediatric patients. NM: To date, no prospective trials have been conducted in this area. In the United States, were trying to reduce preventable hospital readmissions, and we know that many medication-related issues are preventable. ED visits can ...
An observational study to analyze predisposing factors, causality, severity and preventability of adverse drug reactions among...
An observational study to analyze predisposing factors, causality, severity and preventability of adverse drug reactions among multidrug resistant tuberculosis patients treated under RNTCP program in Northern India
Collection, Evaluation and Assessment of Adverse Drug Reactions on the Oncology Ward - Full Text View - ClinicalTrials.gov
The proposed cohort study collected within a 5-month observation period adverse drug reaction (Adverse Drug Events - ADE) in patients at the Department of Oncology at the University of Zurich. ADE have been recorded using prospective monitoring and assessed using standardized algorithms regarding causality and severity. Data sources included information from the medical records, laboratory values and internal rounds. Additional information has been collected using a standardized patient questionnaire.. The primary endpoints of this study are to determine the frequency of ADE, the comparison of the quality of data sources and collection methods for the detection of ADE in regard to patient characteristics, size, number of medications, the category of ADE, severity, causation, diagnosis, hospitalization, cause of hospitalization and medication cause. Secondary endpoint is the assessment of the ADE causality, severity and predictability. ...
Data-driven prediction of adverse drug reactions induced by drug-drug interactions | BMC Pharmacology and Toxicology | Full Text
The expanded use of multiple drugs has increased the occurrence of adverse drug reactions (ADRs) induced by drug-drug interactions (DDIs). However, such reactions are typically not observed in clinical drug-development studies because most of them focus on single-drug therapies. ADR reporting systems collect information on adverse health effects caused by both single drugs and DDIs. A major challenge is to unambiguously identify the effects caused by DDIs and to attribute them to specific drug interactions. A computational method that provides prospective predictions of potential DDI-induced ADRs will help to identify and mitigate these adverse health effects. We hypothesize that drug-protein interactions can be used as independent variables in predicting ADRs. We constructed drug pair-protein interaction profiles for ~800 drugs using drug-protein interaction information in the public domain. We then constructed statistical models to score drug pairs for their potential to induce ADRs based on drug pair
Pharmacogenetic biomarkers for chemotherapy-induced adverse drug reactions
Cancer is a serious disease expected to be the world-leading cause of death in the 21st century. The use of harsh chemotherapies is motivated and accepted but, unfortunately, is often accompanied by severe toxicity and adverse drug reactions (ADRs). These occur because the classical chemotherapies common modes of action effectively kill and/or reduce the growth rate not only of tumour cells, but also of many other rapidly dividing healthy cells in the body. There are also considerable interindividual differences in ADRs, even between patients with similar cancers and disease stage treated with equal doses; some experience severe to life-threatening ADRs after one dose, leading to treatment delays, adjustments, or even discontinuation resulting in suboptimal treatment, while others remain unaffected through all treatment cycles. Being able to predict which patients are at high or low risk of ADRs, and to adjust doses accordingly before treatment, would probably decrease toxicity and patient ...
Comparison of traditional trigger tool to data warehouse based screening for identifying hospital adverse events | BMJ Quality ...
We found relatively poor agreement between traditional trigger tool and EDW based screening with only approximately a third of all AEs detected by both methods. Our results were consistent across designations of preventability and severity of AEs. Prior studies similarly revealed poor agreement between computerised and trigger tool based strategies to detect AEs. In a study focusing on ADEs, Jha and colleagues reported that a computer based method detected 45% of events, trigger tool based screening detected 65% and only 12% were detected by both methods.14 More recently, Tinoco and colleagues reported that a computerised surveillance system detected more hospital acquired infections than trigger tool based screening, but a similar number of ADEs.19 Importantly, the study found that only 26% of hospital acquired infections and 3% of ADEs were detected by both methods.19 Our study provides additional support that computer facilitated screening may complement the traditional trigger tool approach ...
Adverse Drug Reaction (ADR) | Trending
Adverse Drug Reaction (ADR): is an injury caused by taking medication. ADRs may occur following a single dose or prolonged administration of a drug or resu
RePub, Erasmus University Repository: Exploratory Study of Signals for Asthma Drugs in Children, Using the EudraVigilance...
Introduction As asthma medications are frequently prescribed for children, knowledge of the safety of these drugs in the paediatric population is important. Although spontaneous reports cannot be used to prove causality of adverse events, they are important in the detection of safety signals. Objective Our objective was to provide an overview of adverse drug events associated with asthma medications in children from a spontaneous reports database and to identify new signals. Methods Spontaneous reports concerning asthma drugs were obtained from EudraVigilance, the European Medicine Agencys database for suspected adverse drug reactions. For each drug-event combination, we calculated the proportional reporting ratio (PRR) in the study period 2011-2017. Signals in children (aged 0-17 years) were compared with signals in the whole population. Analyses were repeated for diferent age categories, by sex and by therapeutic area. Results In total, 372,345 reports in children resulted in 385 diferent ...
A prospective study of adverse drug reactions associated with chemotherapy in patients of carcinoma head and neck in Government...
A prospective study of adverse drug reactions associated with chemotherapy in patients of carcinoma head and neck in Government Cancer Hospital Indore, India
Australian Adverse Drug Reactions Bulletin, Vol 23, No 3 | Therapeutic Goods Administration (TGA)
Prepared by the Adverse Drug Reactions Advisory Committee (ADRAC) and the Office of Medicine Safety Monitoring (OMSM) of the TGA.
Australian Adverse Drug Reactions Bulletin, Vol 27, No 2 | Therapeutic Goods Administration (TGA)
Prepared by the Adverse Drug Reactions Advisory Committee (ADRAC) and the Office of Medicine Safety Monitoring (OMSM) of the TGA.
Adverse Drug Reactions Dr.T.R.Ramanujam | Medindia
What is Adverse Drug Reactions (ADR)? Any noxious, unintended & undesired effect of a drug, which occurs at a dose used in humans for prophylactic, diagnostic or therapeutic purposes.
A Prospective Study on Antibiotics-associated Spontaneous Adverse Drug Reaction Monitoring and Reporting in a Tertiary Care...
A Prospective Study on Antibiotics-associated Spontaneous Adverse Drug Reaction Monitoring and Reporting in a Tertiary Care Hospital
The Ontario Adverse Drug Reaction Reporting Program | SpringerLink
The Ontario Adverse Drug Reaction Reporting Program. React. Wkly. 113, 2 (1985). https://doi.org/10.1007/BF03293420. Download ...
Adverse Drug Reactions Flashcards by Rachel Hughes | Brainscape
Study Adverse Drug Reactions flashcards from Rachel Hughes's university of aberdeen class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Drug Safety Alerts
Drug Injury Watch provides developing information about prescription drug side effects as well as up-to-date news from the legal, medical, FDA, and pharmaceutical sectors.
Generic Drug Safety
Drug Injury Watch provides developing information about prescription drug side effects as well as up-to-date news from the legal, medical, FDA, and pharmaceutical sectors.
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Medications are two-sided swords and statins are no exclusion. characterizes its - Human Cytomegalovirus Inhibition by Cardiac...
Keywords: statins, testosterone, drug side effects Background For so long, statins seemed so simple. All the news, or almost all the news, was good news. However, our confidence, or was it smugness, that we knew all we needed to know about this important class of medicines has ended with XL765 the recent evidence that diabetes mellitus may be a side-effect of statin therapy , a realization that comes disappointingly late in the game given how many years statins have been used and how many statin studies have been performed; further proof that randomized medical tests (RCTs) are better checks of the XL765 benefits than the risks of therapies and that RCTs are only one element in the full montage of evidence that needs to be put together about the benefits and risk of drug therapy. Todays research by Schooling et al.  examines another concern that will not seem to have obtained the interest it should get - perform statins lower testosterone and, if therefore, could that impact end up being ...
... to work out which genetic factors contribute to our chances of becoming unwell or of suffering from drug-related side-effects. ... Adverse reactions to prescription drugs delay recovery and drain healthcare resources. Generation Scotland is therefore ... Kongkaew C, Noyce PR, Ashcroft DM (July 2008). "Hospital admissions associated with adverse drug reactions: a systematic review ... Disease risk and drug response are examples of complex traits. Instead of having a single cause, complex traits typically ...
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The side effects were less severe in the high- dose treatment group and thus were not related to the dosage of VIR- 576. In ... VIR-576 was well tolerated and did not cause major adverse effects. Retrovirus HIV Antiretroviral drug Fusion ... This fact allows the union of the subunits during the reaction with the gp41 and also allows them to act simultaneously. Thanks ... and most of them didn't show secondary effects. Generally, the effects were temporal and tolerable like constipation, headaches ...
Adverse Reactions - reported adverse reactions and side-effects.. *U.S. National Library of Medicine: Drug Information Portal ... The basis for this broader spectrum of activity of lamotrigine is unknown, but could relate to actions of the drug on voltage- ... The side effect profile varies for different patient populations. Overall adverse effects in treatment are similar between ... Common side effects include sleepiness, headache, vomiting, trouble with coordination, and rash. Serious side effects ...
All of the opioids can cause side effects. Common adverse reactions in patients taking opioids for pain relief include nausea ... Due to severe side effects such as tardive dyskinesia, haloperidol is now rarely used. A related drug, prochlorperazine is more ... Candiotti KA, Gitlin MC (July 2010). "Review of the effect of opioid-related side effects on the undertreatment of moderate to ... Opioid side effects (Vimeo) (YouTube)-A short educational film about the practical management of opioid side effects.. ...
The most prominent side-effects of this drug are dose-related hemolysis (which may lead to hemolytic anemia) and ... Björkman A, Phillips-Howard PA (1991). "Adverse reactions to sulfa drugs: implications for malaria chemotherapy". Bull. World ... Common side effects include nausea and loss of appetite. Other side effects include liver inflammation and a number of types of ... Jopling WH (1983). "Side-effects of antileprosy drugs in common use". Lepr Rev. 54 (4): 261-70. doi:10.5935/0305-7518.19830032 ...
Adverse drug reactions. The common, adverse drug reactions (side effects) are the same as with other PDE5 inhibitors. The ... Vardenafil's indications and contraindications are the same as with other PDE5 inhibitors; it is closely related in function to ... frequent vardenafil-specific side-effect is nausea; the infrequent side effects are abdominal pain, back pain, photosensitivity ... "Food and Drug Administration. 2007-10-18. Retrieved 2009-08-06.. *^ Kloner, Robert A. (2005-12-26). "Pharmacology and drug ...
Other side effects include allergic reactions. It is in the calcitonin gene-related peptide antagonist class of medications. It ... The most common adverse effects are reactions at the injection site, which occurred in 43 to 45% of people in studies (as ... ". "AJOVY prescribing information" (PDF). Drugs@FDA: FDA-Approved Drugs. Retrieved 11 July 2020. "Fremanezumab". Drug ... The most common side effect is pain and redness at the site of injection. ...
Side effects of cyproterone acetate
Adverse Drug Reactions Advisory Committee (February 2004). "Australian Adverse Drug Reactions Bulletin, Volume 23, Number 1". ... The most common adverse reactions are related to the liver with 32 reports. Other more commonly reported reactions include ... Aronson JK (21 February 2009). Meyler's Side Effects of Endocrine and Metabolic Drugs. Elsevier. pp. 150-152. ISBN 978-0-08- ... Chitturi, Shivakumar; Farrell, Geoffrey C (2013). "Adverse Effects of Hormones and Hormone Antagonists on the Liver". Drug- ...
Studies suggest that loperamide is more effective and has lower neural side effects. Adverse drug reactions most commonly ... Florey, Klaus (1991). Profiles of Drug Substances, Excipients and Related Methodology, Volume 19. Academic Press. p. 342. ISBN ... "Drugs@FDA: FDA Approved Drug Products". U.S. Food and Drug Administration (FDA). Archived from the original on 6 May 2016. ... "Drugs@FDA: FDA Approved Drug Products". U.S. Food and Drug Administration (FDA). Archived from the original on 6 May 2016. ...
Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced ... Most people develop side effects. Common side effects include low white blood cell counts, loss of appetite, vomiting, hair ... Other severe side effects include an increased future risk of cancer, infertility, allergic reactions, and pulmonary fibrosis. ... increasing both pharmacologic and toxic effects of the drug; alternatively, drugs that inhibit hepatic microsomal enzymes (e.g ...
The most common side effects include infections, hypertension, infusion-related reactions, and pyrexia. The U.S. Food and Drug ... infusion reactions (27%), and fever (24%). Serious adverse effects occurred in about half of the subjects studied in the ... In the clinical trials that lead to emapalumab's FDA approval, the most commonly reported adverse effects were infections (56 ... "Emapalumab Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). 26 March 2010. Retrieved 19 March ...
... and rated the adverse effects of these drugs lower than non-users, showing more confidence in the result of these drugs. In a ... While there were no reported side effects from DBS, 18% of the patients suffered from device related complications such as ... In the drug trials, participants reported the following adverse reactions to the consumption of donepezil, memantine, MPH, or ... Neuroenhancement drugs need to be assessed further for their merits and adverse effects, making it easier for policy makers to ...
... might show adverse drug reactions (ADRs) characteristic of the sulfa related drugs. Silodosin shows high affinity and ... Today phenoxybenzamine is not the first choice due to many side effects like lowering blood pressure. First selective alpha-1 ... Carruthers, S. G. (July 1994). "Adverse effects of alpha 1-adrenergic blocking drugs". Drug Safety. 11 (1): 12-20. doi:10.2165/ ... since the adverse effects of Prazosin are dose-related. This is also the case for Tamsulosin and it may be assumed that the ...
Examples of drug responses include adverse drug reactions, changes in drug efficacy and alterations in how quickly or slowly a ... drugs, phenotypes (including diseases and side effects) and PubMed IDs (PMIDs). Variant annotations are summaries describing ... PharmGKB has many different types of PGx-related information available through the website, discussed in the sections below. ... EMA-approved drug labels (known as European Public Assessment Reports (EPARs)) are manually searched for using the drugs in the ...
Adverse drug reaction
Evans WE, McLeod HL (February 2003). "Pharmacogenomics--drug disposition, drug targets, and side effects". The New England ... or a low therapeutic index of the drug (e.g. nausea from digoxin), and they are therefore predictable. They are dose-related ... Pathogenesis of adverse drug reactions. In: Davies DM, ed. Textbook of adverse drug reactions. Oxford: Oxford University Press ... of patients had an adverse drug reaction to at least one drug, and pharmacist involvement helps to pick up adverse drug ...
... careful extraction gives an acceptable frequency of adverse reactions, which are largely related to the gastrointestinal tract ... a drug safety bulletin advising consumers not to use medicines containing lei gong teng due to potentially serious side effects ... A 2016 review found gastrointestinal symptoms in 13%, adverse reproductive outcomes in 12%, adverse skin reactions in 8%, ... Serious side effects, however, occur frequently enough to make the risks of taking it higher than the possible benefits. At ...
... mechanism of estramustine-related adverse reactions?". Int. J. Urol. 16 (10): 836-41. doi:10.1111/j.1442-2042.2009.02374.x. ... The side effects of EMP overall have been described as relatively severe. The most common side effects of EMP have been ... 114-. ISBN 978-94-011-4439-1. "Drugs@FDA: FDA Approved Drug Products". United States Food and Drug Administration. Retrieved 29 ... These side effects are due to high estrogen levels and low testosterone levels. Prophylactic irradiation of the breasts can be ...
... and prior knowledge of the severe adverse side effects for geriatric patients, including deep vein thrombosis, toxic reactions ... Pharmacology of the Endocrine System and Related Drugs: Progesterone, Progestational Drugs and Antifertility Agents. II. ... The most common side effect of MGA is weight gain, with an incidence of 15 to 70% at the high dosages used to treat breast ... This is based on the fact that no virilizing side effects have been observed with the use of MGA in patients of either sex at ...
Psychiatry maintain that psychiatrists exaggerate the evidence of medication and minimize the evidence of adverse drug reaction ... but rather induce undesirable side effects. For example, though children on Ritalin and other psycho-stimulants become more ... This has not been shown to be directly related to the therapeutic use of stimulants, but to neuroleptics. The diagnosis of ... partly due to serious adverse effects such as tardive dyskinesia, and partly due their "chemical straitjacket" effect and their ...
Adverse effects are mainly related to its antimuscarinic effects. Common adverse drug reactions (≥1% of people) include: dry ... Common side effects include a dry mouth, runny nose, upper respiratory tract infection, shortness of breath and headache. ... Severe side effects may include angioedema, worsening bronchospasm, and QT prolongation. Tentative evidence has not found harm ...
Aronson JK (4 March 2014). Side Effects of Drugs Annual: A worldwide yearly survey of new data in adverse drug reactions. ... These mortality-related effects are thought to be a consequence of androgen deprivation, rather than a specific drug-related ... This could, in turn, result in increased free concentrations of such drugs and increased effects and/or side effects, ... Common side effects in men include breast enlargement, breast tenderness, and hot flashes. Other side effects in men include ...
Another drug is prescribed to treat the new condition, and an adverse drug side-effect occurs that is again mistakenly ... related physiological changes when trying to minimize the likelihood that an older person will develop an adverse drug reaction ... As each condition is treated with a specific drug, a correlating side-effect of each drug comes into play. If a doctor fails to ... acknowledge all the drugs that a patient is taking, an adverse drug reaction may be misinterpreted as a new medical condition. ...
... may be associated with such adverse effects as second primary malignancy, severe cutaneous reactions, ... Common side effects include diarrhea, itchiness, joint pain, fever, headache, and trouble sleeping. Severe side effects may ... In March 2008, the U.S. Food and Drug Administration (FDA) included lenalidomide on a list of twenty prescription drugs under ... tumor flare reaction, hypothyroidism, and hyperthyroidism. Lenalidomide is related to thalidomide, which is known to be ...
To avoid side effects, it is recommended for patients with chronic kidney failure or cancer to use the lowest possible dose ... Other reported adverse reactions include increased risk of seizure, hypotension, and chest pain. Darbepoetin alfa is not ... Amgen advised the U.S. Food and Drug Administration (FDA) as to the results of the DAHANCA 10 clinical trial. The DAHANCA 10 ... A recent study has extended these findings to treatment of patients exhibiting cancer-related anemia (distinct from anemia ...
Gastrointestinal tolerability is better than that of the related drug indometacin. Severe allergic reactions and haematopoietic ... Common side effects (in about 1-10% of patients) include gastrointestinal problems typical of NSAIDs, such as nausea, diarrhoea ... as well as for the typical NSAID adverse effects. An advantage of acemetacin is that it reduces gastric damage as compared to ... increased frequency of side effects, especially peptic ulcers and gastrointestinal bleeding diuretics, ACE inhibitors and other ...
The most prevalent research on prescription drugs with side effects of macropsia deals with zolpidem and citalopram. Zolpidem ... and although it has proven beneficial effects, there have been numerous reported cases of adverse perceptual reactions. One of ... there were no lasting residual effects. It is believed that zolpidem-related macropsia is more prevalent in women because ... and neither of the drugs' side effects can be supported by experimental evidence. Citalopram is an antidepressant that inhibits ...
... with mild to moderate adverse events. Primarily GI-related adverse events were reported. Nitazoxanide has gone through Phase II ... The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis; these symptoms include ... Nitazoxanide is the prototype member of the thiazolides, which is a drug class of structurally-related broad-spectrum ... and observed a significant adverse reaction (poorly tolerated nausea) only with the very high dose (total dose, 56 g). While ...
J. K. Aronson (2011). Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. Elsevier. ... Ayub M, Levell MJ (August 1989). "The effect of ketoconazole related imidazole drugs and antiandrogens on [3H] R 1881 binding ... Jeffrey K. Aronson (21 February 2009). Meyler's Side Effects of Endocrine and Metabolic Drugs. Elsevier. pp. 150-. ISBN 978-0- ... "Adverse Effects of Hormones and Hormone Antagonists on the Liver". Drug-Induced Liver Disease. pp. 605-619. doi:10.1016/B978-0- ...
Phase III trials showed significant responses although many subjects had mild adverse reactions of bruising, swelling, pain, ... September 1980). "Effect of high-fat, high-beef diet and of mode of cooking of beef in the diet on fecal bacterial enzymes and ... Bile acids are related to the itching (pruritus) which is common in cholestatic conditions such as primary biliary cirrhosis ( ... Different vertebrate families have evolved to use modifications of most positions on the steroid nucleus and side-chain of the ...
An exception to the normal thinking regarding side-effects is Homeopathy. Since 1938, the U.S. Food and Drug Administration ( ... d) No adverse effects - Standard treatment is replaced with "alternative" treatment, getting rid of adverse effects, but also ... 2006). "Drug-related hepatotoxicity". New England Journal of Medicine. 354 (7): 731-39. doi:10.1056/NEJMra052270. PMID 16481640 ... Even low-risk medications such as antibiotics can have potential to cause life-threatening anaphylactic reactions in a very few ...
Side effects include increased skin photosensitivity, dryness, redness, and occasional peeling. Sunscreen use is often ... The frequency of adverse events was about twice as high with isotretinoin use, although these were mostly dryness-related ... "Drug Trials Snapshots: Aklief". U.S. Food and Drug Administration (FDA). 11 October 2019. Archived from the original on 19 ... If the inflammatory reaction is severe, the follicle can break into the deeper layers of the dermis and subcutaneous tissue and ...
Common side effects, which often occur within two hours of the medication being given, include rash, itchiness, low blood ... Serious adverse events, which can cause death and disability, include: *Severe infusion reaction. ... Rituximab Information from the US Food and Drug Administration. *U.S. National Library of Medicine: Drug Information Portal - ... Burton C, Kaczmarski R, Jan-Mohamed R (2003). "Interstitial pneumonitis related to rituximab therapy". N Engl J Med. 348 (26): ...
Hematopoietic stem cell transplantation
44 percent of patients reported having adverse side effects after peripheral blood HSCT. Side effects included pain prior ... and found a serious cardiovascular adverse reaction rate of about 1 in 1500. This study reported a cardiovascular-related ... Drug risks. Filgrastim is typically dosed in the 10 microgram/kg level for 4-5 days during the harvesting of stem cells. ... Graft-versus-tumor effect. Main article: Graft-versus-tumor effect. Graft-versus-tumor effect (GVT) or "graft versus ...
"Synthroid (Levothyroxine Sodium) Drug Information: Uses, Side Effects, Drug Interactions and Warnings". RxList. Archived from ... Side effects. Adverse events are generally caused by incorrect dosing. Long-term suppression of TSH values below normal ... The related drug dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia (elevated ... Allergic reactions to the drug are characterized by symptoms such as difficulty breathing, shortness of breath, or swelling of ...
Effects. Effects upon health. Several studies have documented health and economic benefits related to smoking bans ... "an evaluation of the official hospitality sector data shows there has been no adverse economic effect from the introduction of ... Russia's reaction to tobacco was unique. While most countries banned tobacco upon its arrival, they legalized it shortly ... A side room with no dance floor can be designated for smoking. ... Drug and Alcohol Review. 37 (7): 912-921. doi:10.1111/dar.12848 ...
... in the setting of negative media coverage and fears of vaccine side effects. The fate of LYMErix was described in the ... of children with only mild or moderate and transient adverse effects. LYMErix was approved on the basis of these trials by ... "Infection and Drug Resistance. 8: 119-128. doi:10.2147/IDR.S66739. PMC 4440423. PMID 26028977.. ... B. burgdorferi sensu lato is made up of 21 closely related species, but only four clearly cause Lyme disease: B. mayonii (found ...
... are more commonly associated with serious related adverse effects than other professionals following manipulation. ... adverse reactions appear to be more common following manipulation than mobilization. The most frequently stated adverse ... Joseph C. Keating, Jr. (1997). "Chiropractic: science and antiscience and pseudoscience side by side". Skept Inq. 21 (4): 37-43 ... American chiropractors found that a slight majority favored allowing them to write prescriptions for over-the-counter drugs.[37 ...
GABAA receptor positive allosteric modulator
But this was not used for long because of adverse side effects. ... Barbituric acid can form a large variety of barbiturate drugs by using the Knoevenagel condensation reaction. ... so these studies do not show which of the α subunits are related to the depressive like symptoms. Other studies with α2 ... In psychopharmacology, GABAA receptor PAMs used as drugs have mainly sedative and anxiolytic effects. Examples of GABAA PAMs ...
Another possible side effect is an infection of the nervous system, which occurs in one in 200,000 to 300,000 cases, causing ... Ribavirin and other antiviral drugs, as well as treatment with interferons, do not have a positive effect in patients. ... "Infectious Diseases Related to Travel". Yellow Book. Centers for Disease Control and Prevention. Archived from the original on ... Barrett AD, Teuwen DE (June 2009). "Yellow fever vaccine - how does it work and why do rare cases of serious adverse events ...
Adverse effects. The incidence of adverse events is not correlated with age; however, adverse events occur more often in ... This is sometimes referred to as the 'cheese effect'. These side effects are due to irreversible inhibition of MAO in the gut ... An update on drug interactions". Drug Saf. 14 (4): 219-27. doi:10.2165/00002018-199614040-00002. PMID 8713690.. ... none experienced a tyramine-mediated hypertensive reaction. As the pressor effect of moclobemide is so low, dietary ...
Adverse effects. Allergic reactions to ginger generally result in a rash. Although generally recognized as safe, ginger can ... If consumed in reasonable quantities, ginger has few negative side effects. It is on the FDA's "generally recognized as ... Spinella M (2001). The Psychopharmacology of Herbal Medications: Plant Drugs That Alter Mind, Brain, and Behavior. MIT Press. ... 2007). "Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with ...
2.4 Reactions. *2.5 Disaster appeal fund. *2.6 Effect on survivors. *3 Victims *3.1 Ages ... Wikimedia Commons has media related to Hillsborough disaster.. *Hillsborough Independent Panel (includes digital archives of ... The adverse comments of two doctors regarding the emergency response appeared in the media. Their views were not "the maverick ... Flames were added either side of the Liverpool F.C. crest in memory of the 96 fans who lost their lives in the Hillsborough ...
Adverse effects. Common side effects of dolutegravir in clinical trials included insomnia and headache. Serious side ... Severe side effects may include allergic reactions and liver problems. There is tentative concerns that use during pregnancy ... "FDA Approves Drug to Treat Infants and Children with HIV". U.S. Food and Drug Administration (FDA) (Press release). 12 June ... "Drug Approval Package: Tivicay (dolutegravir) Tablets NDA #204790". U.S. Food and Drug Administration (FDA). 13 September 2013 ...
Index of HIV/AIDS-related articles
... adverse drug reaction - aerosolized - AETC - agammaglobulinemia - Agency for Healthcare Research and Quality (AHRQ) - AHRQ - ... side effects - simian immunodeficiency virus (SIV) - sinusitis - social integration SIT - SIV - Special Projects of National ... antiretroviral drugs - antisense drugs - antitoxins - Antiviral drug - aphasia - aphthous ulcer - apoptosis - approved drugs - ... drug resistance - drug-drug interaction - DSMB - Duffy antigen system - dysplasia - dyspnea ...
The social construct of femininity has adverse effects on women. What is lacking in current research of femininity is "a tool ... Ehrhardt, Anke A.; H. F. L. Meyer-Bahlburg (1981). "Effects of Prenatal Sex Hormones on Gender-Related Behavior". Science. 211 ... Men who wear clothing associated with femininity are often called cross-dressers. A drag queen is a man who wears ... The masculinity side of this dimension represents a preference in society for achievement, heroism, assertiveness and material ...
Side effects. Adverse effects include headache, flushing, nausea, hypotension, reflex tachycardia, and increased ... Fenoldopam mesylate (Corlopam) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial ... Fenoldopam mesylate contains sodium metabisulfite, a sulfite that may rarely cause allergic-type reactions including ... Sympatholytic (and closely related) antihypertensives (C02). Sympatholytics. (antagonize α-adrenergic. vasoconstriction). ...
Chronic obstructive pulmonary disease
Seeking the Prometheus effect". Current Drug Targets. 14 (2): 246-52. doi:10.2174/1389450111314020009. PMID 23256721.. ... with adverse effects include shakiness and heart palpitations. When used with inhaled steroids they increase the risk of ... They work equally well as intravenous steroids but appear to have fewer side effects. Five days of steroids work as well ... Wikimedia Commons has media related to Chronic obstructive pulmonary disease.. *Chronic obstructive pulmonary disease at Curlie ...
Schizophrenia - Simple English Wikipedia, the free encyclopedia
Smoking also reduces the effects and side effects of anti-psychotic drugs, and this may be one of the reasons for the high ... There are various medical conditions, other psychiatric conditions and drug abuse related reactions that may mimic the symptoms ... and that monitoring for adverse treatment effects continues. Regular monitoring for adverse effects is recommended. For most ... These problems may also be side effects of anti-psychotic drugs, antidepressants, sleeping medication and anti-anxiety drugs.[ ...
David M, Hodak E, Lowe NJ (1988). "Adverse effects of retinoids". Medical Toxicology and Adverse Drug Experience. 3 (4): 273-88 ... "FDA information, side effects, and uses / Accutane (isotretinoin) : Drug Interactions". U. S. Food and Drug Administration (FDA ... In a total of 5577 adverse reactions reported to the UK's MHRA up to 31 March 2017, the plurality (1207, or 22%) concerned ... as well as articles related to class effect, dose response, and biologic plausibility found that the literature reviewed was ...
a b Haines, Megan; et al. (2008). "Predictors and Effects of Self-Objectification in Lesbians", Psychology of Women Quarterly ... The highest rate of transmission of HIV to lesbians is among women who participate in intravenous drug use or have sexual ... A third of the respondents believed disclosing their sexual history would result in a negative reaction, and 30% had received a ... Such a perception of women relating to each other connects them through time and across cultures, and Rich considered ...
"Pentamidine Side Effects in Detail - Drugs.com". www.drugs.com. Archived from the original on 2016-11-04. Retrieved 2016-11-04. ... "NebuPent, Pentam (pentamidine) dosing, indications, interactions, adverse effects, and more". reference.medscape.com. Archived ... Some cases of anemia, possibly related to folic acid deficiency, have been described. ... Eye discomfort, conjunctivitis, throat irritation, splenomegaly, Herxheimer reaction, electrolyte imbalances (e.g. hypocalcemia ...
2007 National Drug Strategy Household Survey: detailed findings. Drug statistics series no. 22. Cat. no. PHE 107. Canberra: ... The eastern Torres Strait Islanders in particular are related to the Papuan peoples of New Guinea, and speak a Papuan language. ... Petrol vapour produces euphoria and dulling effect in those who inhale it, and due to its previously low price and widespread ... Both the remote and urban populations have adverse ratings on a number of social indicators, including health, education, ...
This was the Lowest-Observed-Adverse-Effect Level (LOAEL), meaning that other adverse effects were observed at higher intakes.[ ... Side effects. Vitamin C is a water-soluble vitamin, with dietary excesses not absorbed, and excesses in the blood ... a b c U.S. Food and Drug Administration: "Listing of Food Additives Status Part I". Archived from the original on January 17, ... Ascorbic acid is a weak sugar acid structurally related to glucose. In biological systems, ascorbic acid can be found only at ...
Բրոնխիալ ասթմա - Վիքիպեդիա՝ ազատ հանրագիտարան
113,0 113,1 113,2 Adams K. E., Rans T. S. (December 2013)։ «Adverse reactions to alcohol and alcoholic beverages.»։ Annals of ... Dahl R (August 2006)։ «Systemic side effects of inhaled corticosteroids in patients with asthma»։ Respir Med 100 (8): 1307-17։ ... ERS Task Force on the Management of Work-related, Asthma։ «The management of work-related asthma guidelines: a broader ... Asthma»։ in Mary Anne Koda-Kimble, Brian K. Alldredge։ Applied therapeutics: the clinical use of drugs (9th ed.)։ Philadelphia ...
... related to the RT's dose strength, volume and location.. Cardiovascular late side effects have been termed radiation-induced ... techniques and devices are available to lower the occurrence of this type of adverse side effect.. Intestinal discomfort. ... Examples of radiosensitizing drugs include: Cisplatin, Nimorazole, and Cetuximab. The effect of radiotherapy on control of ... The reaction may become more severe during the treatment and for up to about one week following the end of radiation therapy, ...
The most dangerous adverse effect is a severe allergic reaction to either the virus material itself or residues from the hen ... This syndrome has been believed to also be a rare side effect of influenza vaccines. One review gives an incidence of about one ... "Use of antiviral drug in poultry is blamed for drug resistant strains of avian flu". BMJ. 331 (7507): 10. doi:10.1136/bmj. ... People at High Risk of Developing Flu-Related Complications Archived 10 July 2017 at the Wayback Machine CDC publication. ...
Development of analogs of thalidomide
The problems with thalidomide were, aside from the teratogenic side effects, both high incidence of other adverse reactions ... This effect is not related to TNF-α inhibition since potent TNF-α inhibitors such as rolipram and pentoxifylline did not ... Richardson, P. G. (12 July 2002). "Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients ... The problems with thalidomide included; teratogenic side effects, high incidence of other adverse reactions, poor solubility in ...
CIENCIASMEDICASNEWS: Search of: Open Studies | "Adverse Drug Events" OR "Adverse Drug Reactions" OR "Drug Related Side Effects"...
Search of: Open Studies , "Adverse Drug Events" OR "Adverse Drug Reactions" OR "Drug Related Side Effects" - List Results - ... Search of: Open Studies , "Adverse Drug Events" OR "Adverse Drug Reactions" OR "Drug Related Side Effects" - List Results - ... Adverse Drug Reactions. 01/03/2014 05:06 PM EST. Source: National Institutes of Health. Related MedlinePlus Page: Drug ...
ANUSOL-HC SUPPOSITORIES (Hydrocortisone) dosage, indication, interactions, side effects | EMPR
... drug information & product resources from MPR including dosage information, educational materials, & patient assistance. ... Add Drug To My List Compare to related Drugs View/edit/Compare drugs in my list ... Adverse Reactions:. Dermal and epidermal atrophy, poor wound healing, local irritation: folliculitis, hypertrichosis, ... Related Drug Content. *These Unapproved Drugs Were Affected by the FDAs Latest Seizure ...
CHILDREN'S TYLENOL PLUS COUGH & RUNNY NOSE (Acetaminophen,Dextromethorphan,Chlorpheniramine) dosage, indication, interactions,...
... drug information & product resources from MPR including dosage information, educational materials, & patient assistance. ... Adverse Reactions:. Drowsiness, anticholinergic effects, excitability, hepatotoxicity (overdosage).. How Supplied:. Liq-4oz ... Add Drug To My List Compare to related Drugs View/edit/Compare drugs in my list ... Select the drug indication to add to your list. CHILDRENS TYLENOL PLUS COUGH & RUNNY NOSE. Cough and cold ...
Orlaam (Levomethadyl Acetate): Side Effects, Interactions, Warning, Dosage & Uses
... side effects, drug interactions, warnings, patient labeling, reviews, and related medications. ... Adverse Reactions on Stable Therapy The following adverse events were observed in the 25-site, 623-patient usage study in male ... SIDE EFFECTS Drug Description Indications & Dosage Side Effects & Drug Interactions Warnings & Precautions Overdosage & ... home drugs a-z list side effects drug center orlaam (levomethadyl acetate) drug ...
Emergency department visits and hospitalizations for digoxin toxicity: United States, 2005 to 2010. - PubMed - NCBI
digoxin; drug-related side effects and adverse reactions; emergency service, hospital; heart failure; hospitalization ... of ED visits for all adverse drug events among patients≥40 years, but an estimated 3.3% (95% CI, 2.3%-4.4%) of ED visits and ... of hospitalizations for all adverse drug events among patients≥85 years. Estimated annual ED visits and hospitalizations ... Recent data on digoxin prescribing and adverse events are lacking but could help inform the management of digoxin in ...
Side Effects/Adverse Drug Reactions | AHRQ Patient Safety Network
Do emergency physicians attribute drug-related emergency department visits to medication-related problems? Get Citation Hohl CM ... the impact on adverse drug events remains less certain. Overriding of drug-drug interaction alerts and inclusion of free-text ... Serious adverse drug events reported to the FDA: analysis of the FDA Adverse Event Reporting System 2006-2014 database. Get ... This commercial database tracks both adverse drug reactions and medication errors submitted by participating hospitals. ...
Everolimus and Octreotide in Patients With Advanced Carcinoid Tumor - Full Text View - ClinicalTrials.gov
Drug-Related Side Effects and Adverse Reactions. Chemically-Induced Disorders. Everolimus. Sirolimus. Octreotide. ... MedlinePlus related topics: Carcinoid Tumors Drug Information available for: Sirolimus Octreotide acetate Octreotide Everolimus ... Physiological Effects of Drugs. Anti-Bacterial Agents. Anti-Infective Agents. Antibiotics, Antineoplastic. Antifungal Agents. ... Number of Patients With Adverse Events (AEs), Clinically Notable AE, Death, Serious Adverse Events (SAEs) (Open Label Phase) [ ...
Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab - Full Text View -...
Drug-Related Side Effects and Adverse Reactions. Chemically-Induced Disorders. Radiation Injuries. Wounds and Injuries. ... Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab. The safety and scientific ... MedlinePlus related topics: Breast Cancer Drug Information available for: Carvedilol Lisinopril Trastuzumab Carvedilol ... Long-term effects of study drugs as assessed at 18 and 24 months (or 6 and 12 months after completion of trastuzumab therapy ...
Establishment of Drug-induced Liver Injury Databases and Application of Circulating microRNA(miRNA) - Full Text View -...
Drug-Related Side Effects and Adverse Reactions. Chemically-Induced Disorders. Poisoning. To Top ... The purpose of the study is to establish drug-induced liver injury databases in China, make criteria for Chinese drug-induced ... Patients with onset of acute liver injury attributed to antituberculosis drugs or antineoplastic drugs, Roussel Uclaf Causality ... Establishment of Drug-induced Liver Injury Databases and Application of Circulating microRNA(miRNA). The safety and scientific ...
Pathogenesis of Adverse Drug Reactions - Full Text View - ClinicalTrials.gov
Psychotropic Drugs. Seizures. Drug-Related Side Effects and Adverse Reactions. Neurologic Manifestations. Nervous System ... MedlinePlus related topics: Drug Reactions Seizures Urine and Urination Drug Information available for: Valproic acid ... Adverse drug reactions can be broadly defined as any undesirable response associated with therapeutic drug use. A simple and ... The Role of Drug Metabolizing Enzymes in the Pathogenesis Adverse Drug Reactions in Children. ...
Efficacy and safety of infliximab in treating patients with ulcerative colitis: experiences from a single medical center in...
Keywords: China; drug-related side effects and adverse reactions; inflammatory bowel disease; infliximab; recurrence; ... Overall adverse events and relapse-related risk factors were also evaluated. Results: A total of 24 UC patients was finally ... IFX-associated adverse events occurred in 29.2% of patients, with most being mild and transient. Patients with distal or ...
Coronavirus side-effects: People who are more at risk for developing adverse reactions from COVID-19 vaccines | The Times of...
While most of these serious-natured side-effects are still considered to be a rare reaction, they can be concerning for someone ... Similar is the case with other drug-related adverse reactions. Higher the number of medicines being taken disproportionately ... Adverse reactions are considered to be an undesirable side-effect and can be local, systematic or allergic in nature. ... Coronavirus side-effects: People who are more at risk for developing adverse reactions from COVID-19 vaccines. TIMESOFINDIA.COM ...
Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood
Separately, little is known about the role of whole blood as a surrogate tissue in drug-induced toxicity. Accordingly, we in … ... Several studies have characterized drug-induced toxicity in liver and kidney. However, the majority of these studies have been ... Drug-Related Side Effects and Adverse Reactions* / blood * Drug-Related Side Effects and Adverse Reactions* / metabolism ... Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood J Appl Toxicol. 2011 ...
Eliquis Side Effects in Detail - Drugs.com
Includes common and rare side effects information for consumers and healthcare professionals. ... Learn about the potential side effects of Eliquis (apixaban). ... Common adverse reactions were anemia, hemorrhage, and nausea.[ ... The most common adverse events were related to bleeding. ... Some side effects may not be reported. You may report them to ... may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical ...
Apixaban Side Effects in Detail - Drugs.com
Includes common and rare side effects information for consumers and healthcare professionals. ... Learn about the potential side effects of apixaban. ... drug interactions, allergic reactions, or adverse effects. If ... The most common adverse events were related to bleeding. Common adverse reactions were anemia, hemorrhage, and nausea.[Ref] ... Along with its needed effects, apixaban may cause some unwanted effects. Although not all of these side effects may occur, if ...
Executive Summary: Clinical Practice Guideline Safe Medicat... : Critical Care Medicine
critical care intensive care unit; drug-related side effects and adverse reactions; medication errors; patient safety; safety ... critical care intensive care unit, drug-related side effects and adverse reactions, medication errors, patient safety, safety ... Preventable adverse drug events in hospitalized patients: A comparative study of intensive care and general care units. Crit ... Medication errors (MEs) and adverse drug events (ADEs) are a common and significant concern in the ICU since they represent a ...
Side Effects of Serostim (Somatropin (rDNA origin)), Warnings, Uses
A comprehensive guide to side effects including common and rare side effects when taking Serostim (Somatropin (rDNA origin)) ... Breast-Related Terms: When grouped together, breast-related adverse reactions (e.g. nipple pain, gynecomastia, breast pain/mass ... Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking ... SIDE EFFECTS. The following important adverse reactions are also described elsewhere in the labeling:. Acute Critical Illness [ ...
Drug Toxicity - Categorization Of Drug Toxicity
Encyclopedia section of explains in brief about the adverse effects a drug creates on a person in normal dosage or over dosage ... Dose-related reactions are usually predictable, and those unrelated to dose are usually unpredictable. Side effects. Side ... Adverse Drug Reactions Gender as a Risk Factor. Every effort has been made to cover most of the aspects of Adverse Drug ... Drug Toxicity. All drugs are likely to have some side effects. Therapeutic monitoring of drugs is now readily available to make ...
Flupentixol | Davis's Drug Guide
... side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. ... Find information on Flupentixol in Daviss Drug Guide including dosage, ... risk of anticholinergic adverse reactions, including paralytic ileus when used concurrently with other anticholinergics or ... Geri: Consider age-related ↓ in renal, cardiac and hepatic function;. *OB: Use only if expected benefit outweighs potential ...
Perfil de segurança do uso de polivinilpirrolidona-iodo tópico como agente de pleurodese...
Drug-related side effects and adverse reactions. Pleural effusion. Pleurodesis. Povidone-iodine. Quality of life. Treatment ... We found 47 serious adverse events, possibly related to iodopovidone pleurodesis that occurred in 34 patients on 30 days follow ... CONCLUSIONS: Observed common and serious adverse events related to iodopovidone pleurodesis were pain, hypertension, and some ... All adverse events were graduated according to the Common Terminology Criteria for Adverse Events (CTCAEV). Efficacy was ...
Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful...
Key words: Drug-Related Side Effects and Adverse Reactions; Drug Interactions; Intensive Care Units ... these adverse drug events included treatment failure (16.7%) and adverse reactions (83.3%). Most of the adverse drug reactions ... Table 1 Adverse drug events related to drug-drug interactions in patients admitted to the ICU at INI (N=24). ... How many potential drug-drug interactions cause adverse drug reactions in hospitalized patients? Eur J Intern Med. 2013;24(1): ...
Toxicity and Sublethal Effects of Cantharidin on Musca domestica (Diptera: Muscidae).
Drug-related Side Effects And Adverse Reactions. Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. ... Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and ... It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects. ... the results of this study revealed the toxicity of cantharidin against house flies and the adverse effects of sublethal ...
Eliminating Risk of Preventable Adverse Drug Events at the Hospital-community Interface of Care
Analysis for a list includes factors such as DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS ... caused by an adverse drug effect. The adverse effect may result from a direct toxic effect of a drug or metabolite, or an ... Drug Discovery Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs ... Related Companies*Related Events*Related Clinical Trials*Related PubMed Entries*Related Medications ...
Drug Reactions: MedlinePlus
... be aware of possible drug reactions. Learn about drug interactions, side effects, and more. ... ClinicalTrials.gov: Drug-Related Side Effects and Adverse Reactions (National Institutes of Health) ... The drugs might not work, or you could get side effects.. Side effects are unwanted effects caused by the drugs. Most are mild ... Medication/Drug Allergy (National Jewish Health) * Medications and Drug Allergic Reactions (American Academy of Allergy, Asthma ...
Adverse drug reactions in neonates: a prospective study | Archives of Disease in Childhood
Most of the ADRs detected were related to feed intolerance, phlebitis and tachycardia. Most were acute (73%) and lasted between ... Aim To investigate the frequency and characteristics of adverse drug reactions (ADRs) in hospitalised neonates to obtain a ... Data were collected on 313 neonates and 2166 drug prescriptions. Clinical characteristics of patients, drugs administered and ... and reduce the drug dose in another 30 cases. An association was shown between the number of drugs prescribed and ADR onset. ...
Mark Anthony Perazella, MD > Internal Medicine | Yale School of...
Drug-Related Side Effects and Adverse Reactions ... Adverse renal effects of therapeutic agents and other drugs;. * ... Adverse renal effects of therapeutic agents and other drugs; Hypotension in ESRD patients during hemodialysis; HIV-related ... Izzedine H, El-Fekih RK, Perazella MA: The renal effects of ALK inhibitors. Invest New Drugs. 2016 Oct; 2016 Jul 29. PMID: ... Luciano RL, Perazella MA: Nephrotoxic effects of designer drugs: synthetic is not better! Nat Rev Nephrol. 2014 Jun; 2014 Mar ...
Program Members > Yale Cancer Center | Yale School of...
Mt-atp8 (mitochondrially encoded ATP synthase 8) - Rat Genome Database
Drug-Related Side Effects and Adverse Reactions ISO. RGD:1344922. 8554872. ClinVar Annotator: match by term: Brain ... Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & ... Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of ATP8 mRNA]. CTD. PMID:26980303. ... Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of ATP8 mRNA]. CTD. PMID:26980303. ...
Assessing the ability of the Drug-Associated Risk Tool (DART) questionnaire to stratify hospitalised older patients according...
drug-related side effects and adverse reactions. *surveys and questionnaires. *pharmacy service, hospital ... whereas the STOPP statements are associated with adverse drug events.22 The drug regimens were screened for drug-drug ... Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS One 2009;4:e4439.doi: ... Effect of an electronic medication reconciliation application and process redesign on potential adverse drug events: a cluster- ...
NauseaInteractionsAllergic reactionTherapeuticRashDosageToxicityMildAnaphylaxisHeadacheSymptomsMedicationDizzinessRenalDoseSeverePatientsHospitalizationADRsInhibitorsHypersensitivity reactionsClinical TrialsEventsRisksDiarrheaSeverityWARNINGSPatient'sConcurrentOccurPlaceboPharmacokineticsIncidencePharmacovigilanceAcuteHivesPharmacological effectDiseaseFrequentLiverGastrointestinalConcomitantPotential adverseIncludeCommonlyInfusionInterventionUndesirableNonsteroidalVaccine-relatedAnticholinergicImmuneIndicationDosesTreatmentCommon side effectsHigher risk for adverseOccurrenceProlongationSearchAllergyOpioidsPharmacologyInteraction
- Common adverse reactions were anemia, hemorrhage, and nausea . (drugs.com)
- Recognized adverse drug reactions associated with tramadol include dizziness, nausea, headaches and constipation - all common side effects of opioids. (newswise.com)
- Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g. bleeding when using the anticoagulant warfarin ) or a low therapeutic index of the drug (e.g. nausea from digoxin ), and they are therefore predictable. (wikipedia.org)
- Nitritoid reactions (symptoms of facial flushing, nausea , vomiting and hypotension ) may occur when injectable gold sodium aurothiomalate used in the treatment of rheumatoid arthritis , is combined with ACE inhibitors, including Zestril. (medicinenet.com)
- The common side effects of using low dose naltrexone include feeling dizzy, weariness, sleep-related disorders, headaches, abdominal problems such as nausea. (internationaldrugmart.com)
- Study patients experienced known side effects with temozolomide, including nausea, lymphopenia, thrombocytopenia and fatigue. (eurekalert.org)
- Elevated liver enzymes and digestive system conditions, such as constipation and nausea, are rare but possible side effects of statins. (reference.com)
- The elderly often use several drugs on a regular basis and are especially at risk for drug-related harm from side effects and interactions. (nih.gov)
- Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool? (scielo.br)
- The aim of this study was to develop a strategy to identify adverse drug events associated with drug-drug interactions by analyzing the prescriptions of critically ill patients. (scielo.br)
- In the first stage, three prescriptions administered throughout the entire duration of these patients' hospitalization were reviewed, with the Micromedex database used to search for potential drug-drug interactions. (scielo.br)
- With the monitoring of adverse drug events based on prescriptions, a combination of the evaluation of potential drug-drug interactions by clinical pharmacy services and the monitoring of critically ill patients is an effective strategy that can be used as a complementary tool for safety assessments and the prevention of adverse drug events. (scielo.br)
- Recent publications have shown that many potential drug-drug interactions (DDIs) can be identified using drug prescriptions ( 2 , 8 ). (scielo.br)
- Interactions can change the actions of one or both drugs. (medlineplus.gov)
- Multiple drug-drug interactions can be expected with drugs that share, inhibit, or induce these pathways. (thefreedictionary.com)
- Tables are available to check for drug interactions due to P450 interactions. (wikipedia.org)
- The risk of drug interactions is increased with polypharmacy . (wikipedia.org)
- All the guideline don't address adverse drug and disease interactions and they don't address disruption of daily routines, social activities and non-adherence. (myhealth.gov.my)
- Secondary drugs Interactions requires at least 2 drugs to cause interactions for example. (myhealth.gov.my)
- Avoid potential adverse drug interactions. (myhealth.gov.my)
- Drug interactions of Zestril include potassium supplements or diuretics that conserve potassium, for example, hydrochlorothiazide / triamterene , since blood potassium levels may rise to dangerous levels. (medicinenet.com)
- As much as I can appreciate the anecdotes of those who seem to have drug-related side-effects (or interactions), wouldn't it be potentially more productive to report them to an official adverse reactions database like MedWatch? (peoplespharmacy.com)
- Some disadvantages of antibiotics include ineffectiveness against viruses, potential drug interactions, frequent misuse, overuse and potential side effects. (reference.com)
- Drug interactions of meclofenamate sodium include warfarin , a blood thinner, because this may cause excessive bleeding as meclofenamate enhances the effect of warfarin. (medicinenet.com)
- Side effects are related to a variety of interlinked aspects such as chemical properties of drugs, drug-target interactions, pathways involved, and many more. (springer.com)
- Anaphylaxis , a serious allergic reaction, is more rare. (medlineplus.gov)
- Lisinopril should be stopped if there are symptoms or signs of an allergic reaction including feelings of swelling of the face, lips, tongue or throat. (medicinenet.com)
- Swollen lips, or lip edema, can be caused by an allergic reaction to certain medications, such as antibiotics, nonsteroidal anti-inflammatory drugs and ant. (reference.com)
- you have tendency of allergic reaction or hypersensitivity to any human derived injection. (news-medical.net)
- Some of the symptoms of allergic reaction may include skin rash, swelling of the face, lips or tongue, which may cause difficulty swallowing or shortness of breath, tightness of the chest. (news-medical.net)
- A severe allergic reaction may lead to life-threatening anaphylaxis. (livestrong.com)
- Signs and symptoms may not be related to an allergic reaction. (livestrong.com)
- One patient developed a grade 3 vaccine-related allergic reaction to the GM-CSF component of the vaccine. (eurekalert.org)
- When these symptoms occur in a cluster of people and is NOT indicative of the allergic reaction of ONLY one person. (cleaningpro.com)
- Allergic reaction wasn't reported in studies of Onfi. (healthline.com)
- Adverse drug reactions can be broadly defined as any undesirable response associated with therapeutic drug use. (clinicaltrials.gov)
- Toxicity, which occurs due to over dosage of the drug higher than the therapeutic range for a particular patient. (medindia.net)
- Therapeutic monitoring of drugs is now readily available to make some of the drugs even safer. (medindia.net)
- Thyroid hormones may ↓ therapeutic effects. (unboundmedicine.com)
- Nevertheless, when mean scores on a 100-mm visual analog scale for hot flushes and nocturnal sweating were combined, results showed that at the end of cycle 3, the therapeutic effect was similar for all titration groups. (eurekamag.com)
- Given its wide spectrum of activity, oral availability, and familiarity of administration, nelfinavir is a Food and Drug Administration-approved drug that could be repositioned as a cancer therapeutic. (elsevier.com)
- These have included cases of Stevens-Johnson syndrome, toxic epidermal necrolysis and hypersensitivity reactions characterized by rash, constitutional findings and visceral involvement. (who.int)
-  Combination with valproate is common, but this increases the risk of lamotrigine-induced rash , and necessitates reduced dosing due to the interaction of these drugs. (wikipedia.org)
- Effects related to drug allergy or hypersensitivity includes pruritis (itching, often related to hives), urticaria (hives), rash and swollen lips and face. (livestrong.com)
- Common side effects of Libtayo include fatigue, rash and diarrhea. (fda.gov)
- Side effects are Pharmacologic effect, which occurs even when taking normal dosage schedule. (medindia.net)
- Drug allergies are mostly common which is not dosage related, Toxicity is not related to dosage, drug allergy may cause serious toxicity. (medindia.net)
- Such reactions are usually due to inappropriate dosage, especially when drug elimination is impaired. (wikipedia.org)
- It is generally well-tolerated and has a mild side-effect profile, regardless of dosage, when it used as a progestin or antiandrogen in combination with an estrogen such as ethinylestradiol or estradiol valerate in women. (wikipedia.org)
- We determined nationally representative numbers and rates of emergency department (ED) visits for digoxin toxicity in the United States using 2005 to 2010 reports from the National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance project and the National Ambulatory (and Hospital Ambulatory) Medical Care Surveys. (nih.gov)
- Digoxin toxicity accounted for an estimated 1.0% (95% CI, 0.6%-1.4%) of ED visits for all adverse drug events among patients≥40 years, but an estimated 3.3% (95% CI, 2.3%-4.4%) of ED visits and 5.9% (95% CI, 4.0%-7.9%) of hospitalizations for all adverse drug events among patients≥85 years. (nih.gov)
- The severity of the toxicity is usually dose-related. (medindia.net)
- Toxicity may result from decrease in drug clearance in patients with impaired renal clearance. (medindia.net)
- Toxicity and Sublethal Effects of Cantharidin on Musca domestica (Diptera: Muscidae). (bioportfolio.com)
- In conclusion, the results of this study revealed the toxicity of cantharidin against house flies and the adverse effects of sublethal concentrations on biological parameters which may have positive implications for effective management of house flies. (bioportfolio.com)
- monitor closely for related toxicity. (clinicaladvisor.com)
- Certain antiretroviral (ARV) drugs, such as nevirapine and efavirenz, are known to cause toxicity. (scirp.org)
- Certain antiretroviral (ARVs) drugs have well known documented toxicity. (scirp.org)
- damaging the embryo (embryo-fetal toxicity) if the medical drug is used during pregnancy. (canceractive.com)
- Patients treated with the study drug (dose-intensified temozolomide and vaccines) were continuously monitored for toxicity and adverse events. (eurekalert.org)
- IFX-associated adverse events occurred in 29.2% of patients, with most being mild and transient. (nih.gov)
- While most reactions that kick in some hours after the shot is administered are likened to be mild, flu-like symptoms, certain adverse reactions, some of which also require hospitalization have also been reported, with most vaccines. (indiatimes.com)
- 02 /8 How does an adverse reaction differ from a mild one? (indiatimes.com)
- A mild side-effect with a COVID shot is an immune reaction that causes low levels of inflammation in the body, mostly causing reactions nearby to the site of injection. (indiatimes.com)
- Mild side-effects include running a fever, pain at the injection site, body pain, weakness and chills. (indiatimes.com)
- Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. (medlineplus.gov)
- They are dose-related and usually mild, although they may be serious or even fatal (e.g. intracranial bleeding from warfarin). (wikipedia.org)
- These reactions are generally mild and transient, resolving spontaneously within a few minutes to hours. (globalrph.com)
- Meclofenamate sodium is a non-steroidal anti-inflammatory drug ( NSAID ) used to relieve mild to moderate pain . (medicinenet.com)
- These drugs are used for the management of mild to moderate pain, fever, and inflammation. (medicinenet.com)
- Mild to severe muscle pain, weakness and fatigue are the most common side effects of statin use. (reference.com)
- Although 600 mg chinfloxacin had a mild effect on the prolongation of the QT/QTc interval, the effect was less pronounced than that of the positive control, 400 mg moxifloxacin. (asm.org)
- Like most drugs, Onfi may cause mild or serious side effects. (healthline.com)
- Here's a short list of some of the mild side effects that Onfi can cause. (healthline.com)
- To learn about other mild side effects, talk with your doctor or pharmacist, or read Onfi's medication guide . (healthline.com)
- Mild side effects of many drugs may go away within a few days or a couple of weeks. (healthline.com)
- To learn about other mild side effects, talk with your doctor or pharmacist, or read amitriptyline oral tablet's prescribing information . (healthline.com)
- Severe allergic reactions ( anaphylaxis ) and hives occasionally occur. (medicinenet.com)
- Rare side effects include headache, rhinitis (stuffy nose) and back pain. (livestrong.com)
- Headache, throat irritation, bronchitis, muscle pain and upset stomach are common side effects of Advair Diskus, according to WebMD. (reference.com)
- Common side effects associated with cholesterol-reducing statin drugs include difficulty sleeping, headache, drowsiness and flushing of the skin, according. (reference.com)
- Adverse drug events can manifest as numerous signs and symptoms depending on the drug. (oncologynurseadvisor.com)
- Drug withdrawal syndromes which can be of addictive and non-addictive withdrawal for examples B-blocker withdrawal causing angina symptoms or "Addictive drug" withdrawal syndromes from benzodiazepines or narcotics. (myhealth.gov.my)
- When people take cetirizine for allergy symptoms they do not think about side effects when they stop the drug. (peoplespharmacy.com)
- If you develop adverse reactions after you ingest a vitamin B-12 supplement, call your doctor for an evaluation of your symptoms. (livestrong.com)
- More severe symptoms include hives, difficulty breathing and swelling in the face, lips or tongue, according to Drugs.com. (livestrong.com)
- Despite some association with depression, the incidence of depression in women taking CPA in combination with an estrogen has been described by some researchers as "remarkably low", which they have said may be related to the positive psychological effects of the improvement in androgenic symptoms. (wikipedia.org)
- In contrast, the term 'building related illness' (BRI) is used when symptoms of diagnosable illness are identified and can be attributed directly to airborne building contaminants. (cleaningpro.com)
- It's a prescription drug used to relieve symptoms of major depressive disorder (MDD) in adults and some children. (healthline.com)
- Medication errors (MEs) and adverse drug events (ADEs) are a common and significant concern in the ICU since they represent a leading cause of iatrogenic errors in the critically ill population. (lww.com)
- Our Serostim [somatropin (rDNA origin) for injection] Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
- An ADE has been defined as "any injury occurring during the patient's drug therapy and resulting either from appropriate care or from unsuitable or suboptimal care" and includes adverse drug reactions (ADRs) during the recommended use of a medication and any harm secondary to a medication error ( 4 ). (scielo.br)
- The purpose of this study is to determine if a physician's use of electronic medication reconciliation software when writing a patient's discharge prescription will prevent adverse drug ev. (bioportfolio.com)
- Medication reconciliation (MR) at hospital admission, transfer, and discharge has been designated as a required hospital practice to reduce adverse drug events. (bioportfolio.com)
- Adverse drug events and medication problems in hospital at home patients. (bioportfolio.com)
- We did read the medication insert for this drug before starting it, and each time we picked up his next prescription, we compared it to the previous one to see if anything had changed. (latitudes.org)
- We discussed the side effects that were on the medication insert with the neurologist, but she downplayed them. (latitudes.org)
- The research team, led by senior author Ruben Abagyan, PhD, professor of pharmacy, analyzed more than 12 million reports from the FDA Adverse Effect Reporting System (FAERS) and Adverse Event Reporting System (AERS) databases, which chronicle voluntary reports of adverse effects while taking a medication. (newswise.com)
- An adverse drug reaction ( ADR ) is an injury caused by taking a medication . (wikipedia.org)
- Adverse effects may be local, i.e. limited to a certain location, or systemic, where a medication has caused adverse effects throughout the systemic circulation . (wikipedia.org)
- If medication related problems were ranked as a disease, it would be the 5th leading cause of death in the US! (myhealth.gov.my)
- When a side effect of a Migraine drug caused a death, it's written down as an adverse medication reaction. (healthcentral.com)
- You need to know more about the side effects and risks associated with micro-doses of naltrexone before starting your medication plan. (internationaldrugmart.com)
- METHODS A total of 578 consecutive elderly patients admitted to the medical emergency department were interviewed to determine the percentage of admissions due to adverse drug reactions or non-compliance with medication regimens, their causes, consequences, and predictors. (bmj.com)
- RESULTS Eighty three (14.4%) of the 578 admissions were drug related: 39 (6.7%) caused by adverse drug reactions and 44 (7.6%) caused by non-compliance with medication. (bmj.com)
- Factors associated with a higher risk of hospitalisation because of non-compliance were poor recall of the medication regimen, seeing numerous physicians, female sex, polypharmacy, drug costs, and switching over to non-conventional forms of treatment. (bmj.com)
- The drug does not cure the condition, however, and once the medication is stopped, the prostate may begin to enlarge once again. (livestrong.com)
- Because this infection is rare in the U.S., the drug is no longer approved by the Food and Drug Administration (FDA) and cannot be sold in the U.S. Physicians can obtain the medication from CDC after confirmed positive lab results. (cdc.gov)
- Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. (dreamcast-scene.com)
- Libtayo must be dispensed with a patient Medication Guide that describes uses of the drug and its serious warnings. (fda.gov)
- Amitriptyline oral tablets are a generic drug, which means it's an exact copy of the active drug in a brand-name medication. (healthline.com)
- The dizziness results from postural hypotension, a side effect of finasteride that causes blood pressure to drop upon standing. (livestrong.com)
- The renal effects of ALK inhibitors. (yale.edu)
- 8% renal excretion as unchanged drug. (thefreedictionary.com)
- Various diseases, especially those that cause renal or hepatic insufficiency, may alter drug metabolism. (wikipedia.org)
- dose adjustments required for age-related ↓ in renal function and body weight. (unboundmedicine.com)
- Imai E, Chan JC, Ito S et al (2011) Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy: a multicentre, randomised, placebo-controlled study. (springer.com)
- A simple and clinically useful classification is to divide adverse events into those that are dose-dependent and largely predictable from the known pharmacologic properties of the compound in question, and those that are dependent on characteristics unique to susceptible individuals, or idiosyncratic in nature. (clinicaltrials.gov)
- Most Adverse Drug reactions are related to dose. (medindia.net)
- Dose-related reactions are usually predictable, and those unrelated to dose are usually unpredictable. (medindia.net)
- Second endpoints were to describe dose-dependent relation to adverse events, procedure efficacy and patient's quality of life. (usp.br)
- After the occurrence of an ADR, it was necessary to initiate specific treatment in 44 cases, discontinue the drugs involved in 30 cases, and reduce the drug dose in another 30 cases. (bmj.com)
- Dose related response, with the side effects usually predictable but augmented. (brainscape.com)
- The population represented is the Safety Population, which includes any patient who received at least one dose of study drug. (fda.gov)
-  ADRs may occur following a single dose or prolonged administration of a drug or result from the combination of two or more drugs. (wikipedia.org)
- What are the side effects of low dose naltrexone? (internationaldrugmart.com)
- At nearly 1/11th of this standard dose - i.e., less than 5 mg, the drug is found to offer a wide range of benefits. (internationaldrugmart.com)
- In very remote instances, some people have however turned allergic to low dose equivalents of this drug. (internationaldrugmart.com)
- Although the five-milligram dose of finasteride is commonly prescribed for enlarged prostate, the drug is also available in a one-milligram dose to treat hair loss in men. (livestrong.com)
- An increased number of adverse effects were reported by patients who increased their dose. (eurekamag.com)
- Rhabdomyolysis is a life-threatening condition caused by either an excessive dose of statins or the interaction between statins and certain other drugs, explains Mayo Clinic. (reference.com)
- The single-dose pharmacokinetic study, a food effect study, and a multiple-dose pharmacokinetics study were conducted in parts B, C, and D, respectively. (asm.org)
- Part E was a randomized, placebo-controlled and positive-control single-dose, crossover study to evaluate the effect of chinfloxacin on thorough electrocardiographic QT/corrected QT (QTc) interval. (asm.org)
- While milder intensity reactogenic side-effects tend to resolve in a span of 2-3 days, severe, adverse reactions can come up a while later, and take a longer time to resolve, along with the need for a clinical check-up as well. (indiatimes.com)
- Nevirapine may cause severe and life-threatening skin reactions, including fatal cases, mainly during the first 6 weeks of therapy. (who.int)
- Adverse drug events are more frequent and severe in the critically ill population. (oncologynurseadvisor.com)
- The terms "severe" and "serious" when applied to adverse events are technically very different. (wikipedia.org)
- Now, seven years later, I have tried unsuccessfully at least 10 times to quit this drug, and the reaction is more severe each time. (peoplespharmacy.com)
- When I researched the severe itching and found out it was a withdrawal effect, I was shocked! (peoplespharmacy.com)
- Severe allergic reactions to finasteride require immediate medical attention. (livestrong.com)
- These reactions can sometimes become severe or life-threatening and can lead to death. (fda.gov)
- PURPOSE: This phase II trial is studying lisinopril and Coreg CR® to see how well they work compared with a placebo in reducing side effects in patients with HER2-positive breast cancer receiving trastuzumab. (clinicaltrials.gov)
- The purpose of the study is to establish drug-induced liver injury databases in China, make criteria for Chinese drug-induced liver injury patients and evaluate the application of certain circulating miRNA in diagnosis or treatment of drug-induced liver injury. (clinicaltrials.gov)
- Otherwise,collect blood sample or other sample of the patients and study certain miRNA in diagnosis or treatment of drug-induced liver injury. (clinicaltrials.gov)
- If blood samples are drawn from these patients for medical purposes not related to this study the residual blood sample will be recovered before it is discarded for use in genotyping analysis. (clinicaltrials.gov)
- 2. To determine if age-related differences exist regarding the ability of pediatric patients to bioactivate carbamazepine or valproate to reactive metabolites. (clinicaltrials.gov)
- A total of 186 drug prescriptions of 62 HIV/AIDS patients were analyzed. (scielo.br)
- Critically ill patients are at high risk of adverse drug events (ADEs) for several reasons, including the complexity of their clinical conditions, which can involve pharmacokinetic variations and concurrent treatment with multiple drugs ( 1 ). (scielo.br)
- Prospective validation of clinical criteria to identify emergency department patients at high risk for adverse drug events. (bioportfolio.com)
- Clinical characteristics of patients, drugs administered and ADRs were prospectively recorded and analysed. (bmj.com)
- Objectives The Drug-Associated Risk Tool (DART) has been developed as a self-administered questionnaire for patients with the aim of stratifying patients according to their risk of drug-related problems (DRPs). (bmj.com)
- Results Recruited patients had a median age of 79 years and were prescribed a median of 11 drugs. (bmj.com)
- Adverse events are under-appreciated negative consequences that are significant clinical problems for patients undergoing anti-MDR-TB treatment due to longer duration of treatment and more need for concurrent use of multiple second-line drugs. (medscimonit.com)
- 51(6.8%) patients required permanent discontinuation of the offending drug due to adverse events. (medscimonit.com)
- Monitor ECGs and electrolytes periodically in patients with congenital long QTc syndrome, CHF, electrolyte abnormalities, or those who are taking drugs known to prolong the QTc interval. (clinicaladvisor.com)
- Patients in the intensive care unit are at risk for adverse drug events because they are in a fast-paced environment, they receive about two times more medications and more high-risk medications than ward patients, they receive drugs administered intravenously and they have changing organ function that alerts the pharmacokinetics of medications. (oncologynurseadvisor.com)
- Common types of adverse drug events in critically ill patients are acute kidney injury (AKI), cognitive impairment, dysrhythmias and bleeding. (oncologynurseadvisor.com)
- This application allows the clinicians to capture details of Rheumatology patients' disease activity, drug history and drug intolerances in 'real time', thus supporting both the Clinicians' and Commissioners' data requirements. (nice.org.uk)
- b) It alerts clinical team to act on side effects and adverse drug reactions reported by the patients. (nice.org.uk)
- The information available to patients is continuously being updated with additions and deletions of side effects (drug companies have been known to hide information that might discourage patients from taking a drug. (latitudes.org)
- The article describes several cases of patients who developed serious skin reactions while receiving modafinil for sleep or attention-deficit hyperactivity disorders (ADHD). (ebscohost.com)
- The skin reactions presented by the patients include toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS) and. (ebscohost.com)
- HIV positive patients are receiving an array of drugs to treat and prevent opportunistic infection. (scirp.org)
- In clinical trials in patients with hypertension treated with Zestril, 5.7% of patients on Zestril discontinued with adverse reactions. (medicinenet.com)
- In patients with systolic heart failure treated with Zestril for up to four years, 11% discontinued therapy with adverse reactions. (medicinenet.com)
- As a result of all doses of AndroGel, patients showed significant increases in libido and degree of penile erection and significant positive effects on mood and fatigue. (centerwatch.com)
- Factors associated with an increased risk of admission because of an adverse drug reaction were patients with diabetes or neoplasms, and patients using numerous different medications. (bmj.com)
- 3 Although some studies have shown that the incidence of ADRs may be as high as 25%, a rate that is twofold or threefold higher than in younger patients, the notion that age is a critical predisposing determinant of adverse reactions is controversial. (bmj.com)
- 4 However, elderly patients may have multiple disease states and may use a wide variety of drugs, increasing the potential for altered responsiveness to drugs and a higher incidence of adverse effects compared with younger patients. (bmj.com)
- Cempra said solithromycin's performance was hampered by a supply shortage that led 5 patients who received its drug to drop out of the study. (fiercebiotech.com)
- In the trial, 34.3% of solithromycin patients experienced treatment-related adverse events compared with just 13.1% getting moxifloxacin, the company said. (fiercebiotech.com)
- The following adverse reactions were observed in clinical trials and included observations from more than 2,700 patients, 594 of whom were treated for one year and 248 for at least two years. (medicinenet.com)
- The FDA used its Adverse Event Reporting System (FAERS) to announce its concerns over the eye toxicities some patients experienced. (asbestos.com)
- Although none of the drugs have been approved for use with mesothelioma, select patients have been using them in clinical trials or as part of a limited-use program, and some very successfully. (asbestos.com)
- The Mayo Clinic notes that rarely patients report having had side effects associated with finasteride. (livestrong.com)
- All patients had been receiving nonlabeled fluorouracil until the peak of the inflammatory reaction occurred (2 to 3 weeks), ensuring that the time of maximum absorption was used for measurement. (nih.gov)
- Although the trial was small and not designed to evaluate efficacy, four of the 11 study patients survived for more than five years following treatment with a combination of vaccine and the drug temozolomide, a first-line chemotherapy drug for glioblastoma. (eurekalert.org)
- In patients with loiasis, DEC can cause serious adverse reactions, including encephalopathy and death. (cdc.gov)
- in 79% of patients (101 of 128), these events were considered related to the study drug. (eurekamag.com)
- Patients were randomized at a 2-1 ratio to receive either the study drug or placebo, respectively. (mdanderson.org)
- Some individuals have experienced disorientation and memory lapses while using statins, but studies also show that the drugs may improve cognitive function in dementia patients. (reference.com)
- HIV protease inhibitors are Food and Drug Administration approved for HIV patients. (elsevier.com)
- The U.S. Food and Drug Administration today approved Libtayo (cemiplimab-rwlc) injection for intravenous use for the treatment of patients with metastatic cutaneous squamous cell carcinoma (CSCC) or locally advanced CSCC who are not candidates for curative surgery or curative radiation. (fda.gov)
- Patients should also be monitored for infusion-related reactions. (fda.gov)
- The basic idea behind Generation Scotland is that by comparing the genes in large groups of people (such as patients and healthy people, or people who respond well to a medicine and people who do not) researchers will be able to work out which genetic factors contribute to our chances of becoming unwell or of suffering from drug-related side-effects. (wikipedia.org)
- A large proportion of ADRs are known and preventable, and such reactions are often attributable to the coadministration of drugs with an established interaction ( 6 ). (scielo.br)
- Aim To investigate the frequency and characteristics of adverse drug reactions (ADRs) in hospitalised neonates to obtain a better understanding of and improvement in neonatal healthcare. (bmj.com)
- Systemic antimicrobials and caffeine citrate were the drugs that most commonly caused ADRs. (bmj.com)
- Most of the ADRs detected were related to feed intolerance, phlebitis and tachycardia. (bmj.com)
- 1 Adverse drug reactions (ADRs) are an important cause of morbidity and hospital admissions among the elderly. (bmj.com)
- Adverse kidney effects of epidermal growth factor receptor inhibitors. (yale.edu)
- Other concomitant medications including NRTIs, tipranavir/ritonavir, nevirapine, raltegravir, enfuvirtide, and other drugs that are not strong inhibitors/inducers of CYP3A- 300 mg twice daily. (thefreedictionary.com)
- Metabolic side effects observed with protease inhibitors. (ebscohost.com)
- Reports on the metabolic side effects associated with the use of protease inhibitors, which were presented at the 5th Conference on Retroviruses and Opportunistic Infections. (ebscohost.com)
- The effects of ACE inhibitors are particularly beneficial to people with congestive heart failure . (medicinenet.com)
- There have been reports that aspirin and other nonsteroidal anti-inflammatory drugs ( NSAIDS ) such as ibuprofen , indomethacin , and naproxen may reduce the effects of ACE inhibitors. (medicinenet.com)
- Like all ACE inhibitors, lisinopril may cause a nonproductive cough that resolves when the drug is discontinued. (medicinenet.com)
- These three immunotherapy drugs are known as checkpoint inhibitors. (asbestos.com)
- Because these drugs cause toxicities that can be associated with inhibition of Akt, an emerging target in cancer, we assessed the potential of HIV protease inhibitors as anticancer agents. (elsevier.com)
- With the Libtayo approval, the FDA has approved six immune checkpoint inhibitors targeting the the PD-1 / PD-L1 pathway for treating a variety of tumors, from bladder to head and neck cancer, and now advanced CSCC," said Richard Pazdur, M.D., director of the FDA's Oncology Center of Excellence and acting director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research. (fda.gov)
- The long term objective of this research is to characterize the mechanisms responsible for the pathogenesis of idiosyncratic hypersensitivity reactions in children, particularly those involving carbamazepine and other aromatic anticonvulsants. (clinicaltrials.gov)
- The information provided in Snapshots highlights who participated in the clinical trials that supported the FDA approval of this drug, and whether there were differences among sex, race, and age groups. (fda.gov)
- Were there any differences in how well the drug worked in clinical trials among sex, race and age? (fda.gov)
- Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice. (medicinenet.com)
- Recent data on digoxin prescribing and adverse events are lacking but could help inform the management of digoxin in contemporary heart failure treatment. (nih.gov)
- Overall adverse events and relapse-related risk factors were also evaluated. (nih.gov)
- The most common adverse events were related to bleeding. (drugs.com)
- A análise de segurança foi baseada na ocorrência de eventos adversos, graduados de acordo com o Common Terminology Criteria for Adverse Events. (usp.br)
- Despite this, its safety has not been systematically evaluated and some authors have restrictions to its use because of reports of some adverse events related. (usp.br)
- OBJECTIVE: To describe the occurrence of common and serious adverse events after iodopovidone pleurodesis. (usp.br)
- We sought adverse events systematically with clinical and complementary evaluations since before pleurodesis and on several times postoperative. (usp.br)
- In the second stage, a search for adverse drug events in all available medical, nursing and laboratory records was performed. (scielo.br)
- The probability that a drug-drug interaction caused each adverse drug events was assessed using the Naranjo algorithm. (scielo.br)
- these adverse drug events affected 26% of the study population. (scielo.br)
- drug events and preventable drug-related health system utilization following hospital discharge. (bioportfolio.com)
- However, the incidence of adverse drug events in these programs is unknown. (bioportfolio.com)
- This study describes adverse drug events an. (bioportfolio.com)
- Adverse drug events (ADEs) impose a major clinical and cost burden on acute hospital services. (bioportfolio.com)
- Adverse drug events cause or contribute to one in nine emergency department presentations in North America, and are often misdiagnosed. (bioportfolio.com)
- The aim of this study was to determine the incidence of adverse events and their impact on MDR-TB therapy and treatment outcome, and to identify possible drug-event pairs in China. (medscimonit.com)
- Adverse events were determined according to laboratory results or clinical criteria. (medscimonit.com)
- Adverse events occurred commonly during MDR-TB treatment in China, and often resulted in MDR-TB treatment change. (medscimonit.com)
- The occurrence of adverse events affected MDR-TB poor outcome after treatment. (medscimonit.com)
- So, drug-induced events such as abnormal electrolyte values that have not yet resulted in injury (ie, arrhythmia) would not be considered an adverse drug event but are considered drug-related hazardous conditions, since they are an antecedent to injury. (oncologynurseadvisor.com)
- The key to the management of adverse drug events is to prevent the transition of an event such as a drug related hazardous condition from becoming patient injury or at minimum prevent temporary to permanent injury. (oncologynurseadvisor.com)
- A first step is to assure that the reason for the injury is identified, which includes differentiating drug-induced and disease-induced events. (oncologynurseadvisor.com)
- Assuring safety of preventive chemotherapy interventions for the control of neglected tropical diseases: practical advice for national programme managers on the prevention, detection and management of serious adverse events. (who.int)
- Once products are authorised, then PV requirements include the ongoing collection, analysis and reporting of adverse drug reactions, the periodic reporting of cumulative safety events and also the detection and analysis of safety signals for as long as the product is available in the market. (medindia.net)
- There were no treatment limiting adverse events and no adverse events related to the cellular portion of the vaccine. (eurekalert.org)
- The patient was able to continue vaccinations in which the GM-CSF was removed and had no subsequent adverse events. (eurekalert.org)
- While the COVID-19 vaccines we have right now have been found to be safe and effective for use, there have been rare incidental risks of adverse reactions noted. (indiatimes.com)
- The Snapshot is intended as one tool for consumers to use when discussing the risks and benefits of the drugs. (fda.gov)
- Always speak to your health provider about the risks and benefits of a drug. (fda.gov)
- The FDA issued a statement from Janet Woodcock, director of the FDA Center for Drug Evaluation and Research: "The FDA still believes the benefits of taking these drugs for their approved uses and as indicated in the labels continue to outweigh their risks. (asbestos.com)
- Potential Signals of Serious Risks/New Safety Information Identified by the FDA Adverse Event Reporting System. (asbestos.com)
- Apart from monitoring pharma products and their effects overtime, identifying possible risks and side effects and informing the public and medical professionals of updates, pharmacovigilance has to deal with the rising threat of counterfeit drugs flooding the online market and even creeping into some drugstores in some countries. (medindia.net)
- The process of looking for patterns in information to identify cause and effect or answer specific questions, such as whether a treatment or other intervention works and what the risks are. (nice.org.uk)
- What are the risks and side effects of the flu shot? (reference.com)
- Diarrhea is a common side effect in persons taking oral antibiotics due to killing of normal micro-flora of Gastro-intestinal tract in addition to killing pathogenic bacteria. (medindia.net)
- Common side effects associated with antibiotics include diarrhea, indigestion and bloating, loss of appetite and feeling sick, according to NHS Choices. (reference.com)
- or adverse reactions of Grade ≥3 severity. (clinicaladvisor.com)
- How can you classify reaction severity? (brainscape.com)
- Severity is a point on an arbitrary scale of intensity of the adverse event in question. (wikipedia.org)
- The risk and severity of the adverse reactions are related to Loa loa microfilarial density. (cdc.gov)
- The possible adverse reactions or side effects of the drug, warnings, and precautions are discussed. (ebscohost.com)
- Gilenya labelling already contained information on the possible risk of lymphoma, and warnings about how this drug reduces the body's ability to fight infection. (newswire.ca)
- Pharmacology, adverse reactions, warnings and side effects. (dreamcast-scene.com)
- For the eradication of H. pylori the selection of antibiotics should consider the individual patient's drug tolerance, and should be undertaken in accordance with national, regional and local resistance patterns and treatment guidelines. (medicines.org.uk)
- Concurrent use of diuretics and other drugs affecting electrolytes may ↑ risk of QT interval prolongation and serious arrthythmias. (unboundmedicine.com)
- Concurrent use of meclofenamate and cyclosporine , an immunosuppressant, can increase the risk of kidney damage (nephrotoxicity), as meclofenamate tends to increase cyclosporine-induced kidney damage by blocking certain prostaglandins that are important in preventing toxic effects on the kidney. (medicinenet.com)
- Although not all of these side effects may occur, if they do occur they may need medical attention. (drugs.com)
- This is not a complete list of side effects and others may occur. (rxlist.com)
- Hypoglycemia is often related to the treatment of diabetes, but can also occur in persons without diabetes. (newswise.com)
- Allergic and anaphylactoid reactions associated with lidocaine, although rare, can occur. (globalrph.com)
- Serious side effects are rare with most immunotherapy drugs, but they do occur and often prompt the FDA to act. (asbestos.com)
- Galactorrhea (milk outflow) can also occur in men, due to the strong progestogenic effects of CPA. (wikipedia.org)
- Serious side effects from Onfi can occur, but they aren't common. (healthline.com)
- It is not yet known whether lisinopril or Coreg CR® are more effective than a placebo in reducing side effects caused by trastuzumab. (clinicaltrials.gov)
- For those who received the study drug, the median progression-free survival rate was 18.3 months, compared with 3.6 months in those who received placebo. (mdanderson.org)
- Many medications need to be used with special caution because of age-related changes in pharmacokinetics (ie, absorption, distribution, metabolism, and excretion) and pharmacodynamics (the physiologic effects of the drug). (myhealth.gov.my)
- Liposomal formulations have lower incidence of nephrotoxicity and infusion-related reactions. (nih.gov)
- The importance of pharmacovigilance programs that monitor drug safety in the market to maintain the quality and safety of consumer medicines, can never be overstated. (medindia.net)
- Drug-Induced Acute Interstitial Nephritis. (yale.edu)
- Skin reactions, such as hives and rashes, are the most common type. (medlineplus.gov)
- In some cases, the reactions are not necessarily related to the drugs pharmacological effect e.g.dry mouth and tricyclic antidepressants. (brainscape.com)
- The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
- Paraprotein-Related Kidney Disease: Attack of the Killer M Proteins. (yale.edu)
- It is very important to differentiate the aged-related changes from true disease process so as to prevent iatrogenic problem. (myhealth.gov.my)
- As individuals age, they are more likely to suffer from disease, disability, and drug side effects. (bmj.com)
- Disease risk and drug response are examples of complex traits. (wikipedia.org)
-   These are mainly for drugs without much first-pass liver metabolism. (wikipedia.org)
- and other side effects such as vitamin B12 deficiency, weak glucocorticoid effects, and elevated liver enzymes. (wikipedia.org)
- These reactions include the risk of immune-mediated adverse reactions including lung problems (pneumonitis), intestinal problems (colitis), liver problems (hepatitis), hormone gland problems (endocrinopathies), skin (dermatologic) problems and kidney problems. (fda.gov)
- The most frequently reported adverse reactions associated with meclofenamate sodium involve the gastrointestinal system. (medicinenet.com)
- Avoid concomitant QT-prolonging drugs. (clinicaladvisor.com)
- The labels for all three drugs already list uveitis as a potential adverse reaction. (asbestos.com)
-  Serious side effects include lack of red blood cells , increased risk of suicide , Stevens-Johnson syndrome , and allergic reactions . (wikipedia.org)
- The most common side effects of KYBELLA include swelling, bruising, pain, numbness, redness and hardness in the area under the chin or lower jaw that was treated. (fda.gov)
- More serious but rarer adverse drug reactions include serotonin syndrome and increased seizure risk. (newswise.com)
- Side effects in men resulting from the antiandrogenic and antigonadotropic properties of CPA include physical demasculinization, sexual dysfunction (including loss of libido and erectile dysfunction), absence of ejaculate, impaired spermatogenesis, testicular atrophy, and reversible infertility. (wikipedia.org)
- These lists don't include all possible side effects. (healthline.com)
- Various types of ADR, few examples of drugs commonly encountered and the possible mechanisms have been included. (medindia.net)
- The only other drug identified with comparable effect was methadone, an opioid most commonly used to help persons reduce or quit addictions to heroin or other opiates. (newswise.com)
- By far the most commonly reported side effect of finasteride deals with sexual function. (livestrong.com)
- 46 of 228) were the most commonly reported side effects. (eurekamag.com)
- An unintended effect that is harmful or otherwise unwanted, and suspected to be related to, or caused by, a drug, treatment or intervention. (nice.org.uk)
- Any undesirable event experienced by a person while they are having a drug or any other treatment or intervention, regardless of whether or not the event is suspected to be related to or caused by the drug, treatment or intervention. (nice.org.uk)
- Adverse reactions are considered to be an 'undesirable' side-effect and can be local, systematic or allergic in nature. (indiatimes.com)
- Nonsteroidal antiinflammatory drugs (NSAIDs) used to treat pain and inflammation. (medicinenet.com)
- 04 /8 Who has a higher risk for adverse vaccine-related reactions? (indiatimes.com)
- risk of anticholinergic adverse reactions, including paralytic ileus when used concurrently with other anticholinergics or drugs with anticholinergic side effects . (unboundmedicine.com)
- A Health Canada safety review found that Gilenya, like other drugs that suppress the immune system, may increase the risk of lymphomas (lymphocyte cancer) and other cancers, particularly of the skin. (newswire.ca)
- These drugs essentially unmask the cancer cells and allow the immune system to destroy them. (asbestos.com)
- The vision loss was attributed to an immune-related adverse reaction to the drug. (asbestos.com)
- Numerous researches have reported that gold compounds, in addition to their widely studied cytotoxic antitumor effects, also reverse tumor immune escape and directly facilitate the functions of immune cells, leading to enhanced anticancer effects. (frontiersin.org)
- This review mainly summarizes our current understandings of antitumor effects of gold drugs and their relationships with various aspects of antitumor immunity, including innate immunity, adaptive immunity, immunogenic cell death, and immune checkpoints, as well as their roles in adverse effects. (frontiersin.org)
- it is taken for granted that the primarily effect of chemotherapy on the immune system is immunosuppression. (frontiersin.org)
- Hence, we propose a hypothesis that in addition to the classical DNA damage pattern of platinum complexes, the immune system may increase the antitumor activity of these drugs in a synergistic manner. (frontiersin.org)
- By blocking this pathway, the drug may help the body's immune system fight the cancer cells. (fda.gov)
- The multiple physicians they visited may prescribe drugs of similar indication but of different brand names. (myhealth.gov.my)
- ORLAAM (levomethadyl acetate) produces opioid effects and a high degree of opioid tolerance that inhibits drug-seeking behavior and blocks the euphoria produced by the usual doses of heroin . (rxlist.com)
- Upon discontinuation from high doses, CPA can produce adrenal insufficiency as a withdrawal effect. (wikipedia.org)
- ORLAAM (levomethadyl acetate) , used for the treatment of opiate addiction, shall be dispensed only by Opioid Treatment Programs (OTPs) certified by SAMHSA under 42 CFR Part 8, and registered by the Drug Enforcement Administration under 21. (rxlist.com)
- The University of North Carolina Department of Dermatology is conducting a clinical trial to evaluate a drug called cantharidin in the treatment of molluscum contagiosum. (bioportfolio.com)
- The article describes the case of a 65-year-old man who developed a cutaneous lymphoid perivascular reaction during treatment with the protease inhibitor bortezomib for multiple myeloma (MM). (ebscohost.com)
- However the treatment of illness in elderly is very challenging as it involved the patient, the prescriber and the drugs. (myhealth.gov.my)
- Gilenya is a prescription drug used in the treatment of relapsing-remitting multiple sclerosis (MS) to reduce the frequency of attacks (relapses) and delay the progression of physical disability. (newswire.ca)
- Although no non-platinum metal compounds have been approved for cancer treatment, a number of gold drug candidates are being considered. (frontiersin.org)
- A randomized controlled trial comparing the cognitive and emotional effects of GnRH agonists and CPA in 82 men with prostate cancer found no significant differences in scores on the Depression Anxiety Stress Scale-21 (DASS-21) after 6 months of treatment. (wikipedia.org)
- They'll monitor your risk before treatment with this drug. (healthline.com)
Common side effects3
Higher risk for adverse1
- Individuals who are taking several different cholesterol-lowering drugs and those of a small build have a higher risk for adverse reactions to statins. (reference.com)
- Safety signals are generally observed as a disproportional occurrence of certain adverse reactions associated with certain drugs. (medindia.net)
- Chinfloxacin at 400 mg had no effect on prolongation of QT/QTc intervals. (asm.org)
- 2) The rx list web site will open here with the drug search completed. (globalrph.com)
- Some reactions may be side effects rather than related to an allergy. (livestrong.com)
- Newswise - Since its approval in 1995, the opioid tramadol (marketed as ConZip and Ultram) has become a widely prescribed remedy for osteoarthritis and other painful indications, in part because it presents a lesser risk for some side effects and has a lower abuse potential when compared to other opioids. (newswise.com)
- Know the pharmacology of the drug(s). (myhealth.gov.my)