PiperazinesAscaris: A genus of nematodes of the superfamily ASCARIDOIDEA whose species usually inhabit the intestine.Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.Designer Drugs: Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.Receptors, sigma: A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.Serotonin Receptor Agonists: Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.Antinematodal Agents: Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.Receptors, Serotonin: Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.Pyronine: Xanthene dye used as a bacterial and biological stain. Synonyms: Pyronin; Pyronine G; Pyronine Y. Use also for Pyronine B. which is diethyl-rather than dimethylamino-.Mitragyna: A plant genus of the family RUBIACEAE. Members contain antimalarial (ANTIMALARIALS) and analgesic (ANALGESICS) indole alkaloids.Prochlorperazine: A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)Serotonin Antagonists: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.Receptors, Serotonin, 5-HT1: A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to GI-GO G-PROTEINS resulting in decreased intracellular CYCLIC AMP levels.8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)Catatonia: A neuropsychiatric disorder characterized by one or more of the following essential features: immobility, mutism, negativism (active or passive refusal to follow commands), mannerisms, stereotypies, posturing, grimacing, excitement, echolalia, echopraxia, muscular rigidity, and stupor; sometimes punctuated by sudden violent outbursts, panic, or hallucinations. This condition may be associated with psychiatric illnesses (e.g., SCHIZOPHRENIA; MOOD DISORDERS) or organic disorders (NEUROLEPTIC MALIGNANT SYNDROME; ENCEPHALITIS, etc.). (From DSM-IV, 4th ed, 1994; APA, Thesaurus of Psychological Index Terms, 1994)N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.Dopamine Uptake Inhibitors: Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.Delavirdine: A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Receptors, Dopamine D3: A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.Anthelmintics: Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.Pyrantel: A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)Piperidines: A family of hexahydropyridines.Ascariasis: Infection by nematodes of the genus ASCARIS. Ingestion of infective eggs causes diarrhea and pneumonitis. Its distribution is more prevalent in areas of poor sanitation and where human feces are used for fertilizer.Serotonin 5-HT1 Receptor Agonists: Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.Trimetazidine: A vasodilator used in angina of effort or ischemic heart disease.Radioligand Assay: Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Receptor, Serotonin, 5-HT1A: A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN RECEPTOR AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.Receptors, Dopamine D2: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.Dopamine Plasma Membrane Transport Proteins: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Isocyanates: Organic compounds that contain the -NCO radical.Bisbenzimidazole: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.3,4-Methylenedioxyamphetamine: An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons and has been used for that purpose experimentally.Monoacylglycerol Lipases: An enzyme that catalyzes the hydrolysis of glycerol monoesters of long-chain fatty acids EC 3.1.1.23.Anti-Anxiety Agents: Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.Tetrahydronaphthalenes: Partially saturated 1,2,3,4-tetrahydronaphthalene compounds.Diethylcarbamazine: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Biogenic Monoamines: Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Muscle Tonus: The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.Membrane Transport Proteins: Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.Receptor, Serotonin, 5-HT2A: A serotonin receptor subtype found widely distributed in peripheral tissues where it mediates the contractile responses of variety of tissues that contain SMOOTH MUSCLE. Selective 5-HT2A receptor antagonists include KETANSERIN. The 5-HT2A subtype is also located in BASAL GANGLIA and CEREBRAL CORTEX of the BRAIN where it mediates the effects of HALLUCINOGENS such as LSD.1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Motor Activity: The physical activity of a human or an animal as a behavioral phenomenon.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Alkylation: The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.Behavior, Animal: The observable response an animal makes to any situation.Chromatography, Liquid: Chromatographic techniques in which the mobile phase is a liquid.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.Anti-Infective Agents: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Isoquinolines: A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.Spectrometry, Mass, Electrospray Ionization: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.Muscles: Contractile tissue that produces movement in animals.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Simple N-substituted piperazines are found in numerous drug molecules. Sigma-Aldrich has a large selection of piperazine ... Learn More about Piperazines
piperazines.html>Piperazines ... The piperazine scaffold has been classified as a privileged structure and is frequently found in biologically active compounds ... Simple N-substituted piperazines are found in numerous drug molecules. Sigma-Aldrich has a large selection of piperazine ...
  • Recent studies have suggested that GR-89696 and related κ2-selective agonists may be useful for preventing the itching which is a common side effect of conventional opioid analgesic drugs, without the additional side effects of non-selective kappa agonists. (chemchart.com)
  • API Intermediates (4-Chloro Benzhydryl Piperazine, 4-Chloro Benzhydryl Chloride, 2-Thienylethamino (2-Chlorophenyl) Acetate Hydrochloride, Chlorophenyl Glycine Methyl Ester Tartrate Salt, Ethyl Methyl Pyrroline Carboxamide Ethyl Benzene Sulfonamide) Manufacturing and Exporting Unit, Established in 2007, Located at GIDC Panoli, Ankleshwar (The Chemical Hub of India) of Gujarat, India. (karuneshremedies.co.in)
  • Brito AF, Martins JLR, Fajemiroye JO, Galdino PM, De Lima TC, Menegatti R, Costa EA (2012) Central pharmacological activity of a new piperazine derivative: 4- (1-phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester. (springer.com)
  • If you are going to wholesale cheap and high purity 1-[2(2-hydroxyethoxy)ethyl]piperazine dihydrochloride from one of the leading China 1-[2(2-hydroxyethoxy)ethyl]piperazine dihydrochloride manufacturers and factory, please feel free to contact Pharm-Drugs. (royalpharms.net)
  • In addition to their antihistamine effects, H1-receptor antagonists possess pharmacological properties that are not uniformly distributed among this class of drugs, such as anti-inflammatory, anti-allergic and antiplatelet activities. (sigmaaldrich.com)
  • Piperazine-based CCR5 antagonists as HIV-1 inhibitors. (nih.gov)
  • Truncation of the original piperidino-2(S)-methyl piperazine lead structure 2, from a family of muscarinic antagonists, gave compound 8 which has improved selectivity for the HIV-1 co-receptor CCR5 over muscarinic receptors. (nih.gov)
  • The results showed that substitution of phenyl by tolyl, anisol and cumene groups in piperazine family could remarkably decrease acute inflammation in these new drugs. (sigmaaldrich.com)
  • Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive dis. (nih.gov)
  • Boissier JR, Dremont C, Robins R, Pagny J (1961) Tentative de pharmacology previsionelle dans de domain des neuroleptique: actions sedative centralle et adrenolytique de la N (dimethoxy-3,4 phenethyl) N (chloro-2 phenyl) piperazine. (springer.com)
  • The present disclosure provides a deuterium substituted 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine compound with a structure represented by formula. (patents.com)
  • The stimulant effects of piperazines are similar to MDMA ( ecstasy ) but dose for dose they are not as potent. (talktofrank.com)
  • Although banned in a number of countries, they are currently legally available in New Zealand where they are marketed as 'safe' alternatives' to 'illicit' drugs often used in the dance scene such as MDMA and amphetamines. (erowid.org)
  • Club drugs range from entactogens such as MDMA ("ecstasy"), 2C-B ("nexus") and inhalants (e.g., nitrous oxide and poppers) to stimulants (e.g., amphetamine and cocaine), depressants/sedatives (Quaaludes, GHB, Rohypnol) and psychedelic and hallucinogenic drugs (LSD and DMT). (wikipedia.org)
  • Other club drugs, such as amphetamine or MDMA are generally illegal, unless the individual has a lawful prescription from a doctor. (wikipedia.org)
  • Some club drugs can cause adverse health effects which can be harmful to the user, such as the dehydration associated with MDMA use in an all-night dance club setting. (wikipedia.org)
  • MDMA (ecstasy) is a popular club drug in the rave and electronic dance music scenes and in nightclubs. (wikipedia.org)
  • MDMA is sometimes taken in conjunction with other psychoactive drugs, such as LSD, DMT, psilocybin mushrooms and 2C-B. Users sometimes use mentholated products while taking MDMA for its cooling sensation. (wikipedia.org)
  • Deputy Brian O'Shea asked the Minister for Health and Children the substances that have been added to the list of scheduled substances under the Misuse of Drugs Act 1977. (drugsandalcohol.ie)
  • Cocaine is generally acknowledged as one of the most addictive substances ( Das, 1993 ), and drug abuse with cocaine continues to be a major public health concern ( Musto, 1992 ). (aspetjournals.org)
  • The controlled drug 3,4-methylenedioxybenzylpiperazine (3,4-MDBP) has regioisomeric and isobaric substances of mass equivalence, which have similar analytical properties and thus the potential for misidentification. (auburn.edu)
  • The chemical composition of substances sold as piperazines are changing all the time, which is why you can never be sure of what you're getting and how it could affect you. (talktofrank.com)
  • Mixing piperazines with alcohol can be particularly dangerous - the effects of these two substances interact, and you may also be less in control, making use much riskier. (talktofrank.com)
  • The creation of new substances to exploit loopholes in drug control legislation has been a problem since the international drug control system was first established. (drugwarfacts.org)
  • More recently, a number of piperazines, synthetic cathinones and synthetic cannabinoids emerged, which were marketed as 'legal' alternatives to controlled substances. (drugwarfacts.org)
  • In the operating guidelines on the early warning system, EMCDDA [European Monitoring Centre on Drugs and Drug Addiction] made it explicit that 'the term 'new' did not refer to newly invented, but rather 'newly misused'' substances as 'most of the drugs in question were first created many years ago. (drugwarfacts.org)
  • In the profiles of 'new drugs', EMCDDA lists plant-based substances such as Salvia divinorum and khat. (drugwarfacts.org)
  • By the end of December 2017, the EMCDDA was monitoring more than 670 new substances that have appeared on Europe's drug market over the past 20 years. (drugwarfacts.org)
  • It also marked the first time when the new opioids were the single largest group of new substances to appear on the drug market in any one year - a position that has previously been dominated by the cannabinoids and cathinones. (drugwarfacts.org)
  • How long the effects last and the drug stays in your system depends on how much you've taken, your size, whether you've eaten and what other drugs you may have also taken. (talktofrank.com)
  • Did you experience many side effects while taking this drug? (rxwiki.com)
  • In the rave environment, the sensory effects from the music and lighting are often highly synergistic with the drug. (wikipedia.org)
  • Some users enjoy the feeling of mass communion from the inhibition-reducing effects of the drug, while others use it as "party fuel" for all-night dancing. (wikipedia.org)
  • Specifically, the effects of unilateral lesions of nigrostriatal DA neurons on oral dyskinesia and Fos protein expression induced by the non-selective 5-HT(2C) agonist 1-(m-chlorophenyl)piperazine (m-CPP) were examined. (mendeley.com)
  • It includes coverage of dosage and length of time before the drug takes effect, side effects, special precautions, interactions with other food and drugs, standards for use by different age groups, and much more. (google.com)
  • Currently, popular ones have effects profiles similar to stimulants, empathogens, hallucinogens, and cannabis.Little or no formal research has been done on the toxicology or pharmacology of these drugs. (slideshare.net)
  • With support from Doblin, the couple successfully petitioned the Food and Drug Administration to allow them to test the effects of the drug on people who suffered from PTSD. (drugs-forum.com)
  • The pharmaceutical companies and defaulters are playing with the lives of thousands of people who are not aware of the harmful effects of the drugs they sell. (ezsoftech.com)
  • Thanks to a virtually "absent" adverse drug reaction mechanism in the country, drugs like Analgin, Cisapride, Nimesulide and Piperazine, discarded worldwide due to serious side effects are among the bestsellers in India. (ezsoftech.com)
  • India's contribution to the worldwide collection of data on the side effects of different drugs is dismal. (ezsoftech.com)
  • Assessing adverse drug reaction is not an easy task and in a developed country like the US not more than 10% of the side effects are recorded. (ezsoftech.com)
  • Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats. (mendeley.com)
  • Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family which behaves as a serotonin and norepinephrine releasing agent and potent 5-HT2A, 5-HT2B, and 5-HT2C agonist. (chemchart.com)
  • But the results from the cotton pellet-induced granuloma formation in rats showed that none of drugs (I-VIII) were effective to reduce the chronic inflammation. (sigmaaldrich.com)
  • Knowledge of the major pathway for GBR12909 metabolism is important for prediction of the likelihood of drug-drug interactions, which may affect the therapeutic clinical outcome, when this agent is used in cocaine-dependent individuals receiving multiple drug therapy. (aspetjournals.org)
  • It is important to determine which enzymes are responsible for the metabolism of medications during drug development to be able to effectively plan clinical trials and ultimately produce a more informed drug label. (aspetjournals.org)
  • Incubation of new drug candidates with substrates/inhibitors of specific cytochrome P450 isoforms with human liver microsomes and hepatocytes is a powerful tool in the characterization of their P450-mediated metabolism. (aspetjournals.org)
  • BZP may be one of the ingredients in packs of " bath salts "-illicit drugs that are labeled "for a stimulating bath" to evade seizure by law enforcement. (narconon.org)
  • But now bath salts are becoming the next big drug menace . (metafilter.com)
  • Some manufacturers are making designer drugs being sold as bath salts, said Wendy Stephan, health educator with the Florida Poison Information Center in Miami. (metafilter.com)
  • and R 2 is halogen, an aliphatic group having a terminal tertiary amino nitrogen group, an aliphatic group having a terminal piperidine substituent, or an aliphatic group having a piperazine substituent, said combination being effective to produce hypothermia or poikilothermia. (google.com)
  • and R 2 is halogen, an aliphatic group having a terminal tertiary amino nitrogen group, an aliphatic group having a terminal piperidine substituent, or an aliphatic group having a piperazine substituent. (google.com)
  • Results from this trial suggest that single-dose treatment with triclofenol piperazine could be used advantageously for mass therapy. (ajtmh.org)
  • Amine blends that are activated by concentrated piperazine are used extensively in commercial CO2 removal for carbon capture and storage (CCS) because piperazine advantageously allows for protection from significant thermal and oxidative degradation at typical coal flue gas conditions. (wikipedia.org)
  • The new narrow group 'Cathinones' groups all of these drugs together. (abs.gov.au)
  • The proposed mechanism for GBR12909 effect involves slow dissociation of GBR12909 from the DA transporter, which prolongs the action of drug and may be useful as a cocaine antagonist. (aspetjournals.org)
  • Further optimization for pharmacokinetic properties afforded Sch-350634 (1), a prototypical piperazine-based CCR5 antagonist, which is a potent inhibitor of HIV-1 entry and replication in PBMCs. (nih.gov)
  • A selective Histamine-1 antagonist drug used in allergic rhinitis and chronic urticaria. (drugbank.ca)
  • Simple N -substituted piperazines are found in numerous drug molecules. (sigmaaldrich.com)
  • Due to its ability to detect different types of molecules in single cells in situ the method presented here can contribute to a deeper understanding of cell-to-cell variations and can be applied to e.g. pinpoint effector sites of drugs in a signaling pathway. (nih.gov)
  • Piperazines are taken as pills that come in various forms, colours and shapes. (talktofrank.com)
  • In this Harm Reduction Digest Sheridan, Butler, Wilkins and Russell address the emergent phenomenon of so-called 'legal party pills' which have become a significant drug issue in New Zealand and elsewhere. (erowid.org)
  • No evidence of intolerance of the drug was observed in children during therapy with high dosage. (ajtmh.org)
  • Dosage is established depending on the patient's general health status and age, the type of antihelminthic drug used, and the type of parasitic infestation being treated. (encyclopedia.com)
  • Therefore it is necessary to assess the enzymatic pathways (inhibition spectrum) for drug candidates such as GBR12909, which could become an effective treatment for cocaine addiction. (aspetjournals.org)
  • Further we applied drugs disrupting the PDGFRβ signaling pathway at various sites to show that this combined method can concurrently monitor the molecular effect of the drugs, i.e. inhibition of downstream signaling from the targeted node in the signaling pathway. (nih.gov)
  • Piperazines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This group of drugs are also called "designer drugs", as most are synthesized in chemical lab (e.g. (wikipedia.org)
  • The amine (2) was prepared starting from 1-(4-fluorophenyl) piperazine via two steps, and then converted to the corresponding hydrazide (4). (eurekaselect.com)
  • nonetheless, the CO2 absorption rate, heat of absorption, and solvent capacity are increased through the addition of piperazine to amine gas treating solvents, the most common of which is MDEA due to its unmatched high rate and capacity efficiency. (wikipedia.org)