Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)Hydromorphone: An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.Disease Outbreaks: Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.History, 19th Century: Time period from 1801 through 1900 of the common era.Communicable Diseases, Emerging: Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Liver Neoplasms: Tumors or cancer of the LIVER.WalesEnglandLiver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Liver Diseases: Pathological processes of the LIVER.Technology Assessment, Biomedical: Evaluation of biomedical technology in relation to cost, efficacy, utilization, etc., and its future impact on social, ethical, and legal systems.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Hemorrhagic Fever, Ebola: A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.Ebolavirus: A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.Ebola Vaccines: Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Drug Discovery: The process of finding chemicals for potential therapeutic use.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Motion Perception: The real or apparent movement of objects through the visual field.Aminophenols: Phenols substituted in any position by an amino group.Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.Cystic Fibrosis Transmembrane Conductance Regulator: A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.Sweat: The fluid excreted by the SWEAT GLANDS. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products.Respiratory System Agents: Drugs used for their effects on the respiratory system.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Cannabis: The plant genus in the Cannabaceae plant family, Urticales order, Hamamelidae subclass. The flowering tops are called many slang terms including pot, marijuana, hashish, bhang, and ganja. The stem is an important source of hemp fiber.Dronabinol: A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.Anorexia: The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.Anorexia Nervosa: An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)Weight Loss: Decrease in existing BODY WEIGHT.Marijuana Abuse: The excessive use of marijuana with associated psychological symptoms and impairment in social or occupational functioning.Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Mycology: The study of the structure, growth, function, genetics, and reproduction of fungi, and MYCOSES.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Fungi: A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Anti-Asthmatic Agents: Drugs that are used to treat asthma.MycosesGeriatrics: The branch of medicine concerned with the physiological and pathological aspects of the aged, including the clinical problems of senescence and senility.Geriatric Assessment: Evaluation of the level of physical, physiological, or mental functioning in the older population group.Geriatric Nursing: Nursing care of the aged patient given in the home, the hospital, or special institutions such as nursing homes, psychiatric institutions, etc.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Health Services for the Aged: Services for the diagnosis and treatment of diseases in the aged and the maintenance of health in the elderly.Geriatric Psychiatry: A subspecialty of psychiatry concerned with the mental health of the aged.Foraminotomy: Surgical enlargement of the intervertebral foramina to relieve NERVE ROOT COMPRESSION.Extensively Drug-Resistant Tuberculosis: Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.MarylandTuberculosis, Multidrug-Resistant: Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.Tuberculosis: Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.Tuberculosis, Pulmonary: MYCOBACTERIUM infections of the lung.Antitubercular Agents: Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.Mycobacterium tuberculosis: A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
Drugs[edit]. The drugs used by the Siddhars could be classified into three groups: thavaram (herbal product), thadhu (inorganic ... They make a diagnosis after a patient's visit and set about to refer to their manuscripts for the appropriate remedies, which a ... drugs which are soft), and ghandhagam (drugs which are insoluble in water, like sulphur).[15] ... water-soluble inorganic substances or drugs that give out vapour when put into fire), pashanam (drugs not dissolved in water ...
Public opinion on drugs and drug policy Archived 2014-07-15 at the Wayback Machine.. Transform Drug Policy Foundation: Fact ... the patient's response is not always truthful".[72] ... "Information on Drugs of Abuse". Commonly Abused Drug Chart. nih ... Lisbon: European Monitoring Centre for Drugs and Drug Addiction. doi:10.2810/13807. ISBN 978-92-9168-312-3.. [page needed] ... Psychoactive drug. References[edit]. *^ Aizpurua-Olaizola, Oier; Soydaner, Umut; Öztürk, Ekin; Schibano, Daniele; Simsir, ...
Patients with mixed intoxications (e.g. with other CNS active drugs) may show severe or life-threatening symptoms and should be ... An update on drug interactions". Drug Saf. 14 (4): 219-27. doi:10.2165/00002018-199614040-00002. PMID 8713690.. ... Less than 1 percent of the drug is excreted unchanged; 92 percent of the metabolised drug is excreted within the first 12 hours ... Prog Drug Res. 38. pp. 171-297. doi:10.1007/978-3-0348-7141-9_3. ISBN 978-3-0348-7143-3. PMID 1609114.. ...
In one case, hemodialysis was used to reduce bromide's half-life to 1.38h, dramatically improving the patient's condition. ... Olson, Kent R. (1 November 2003). Poisoning & drug overdose (4th ed.). Appleton & Lange. pp. 140-141. ISBN 978-0-8385-8172-8. ...
"International Drug Price Indicator Guide. Retrieved 27 November 2015.. *^ a b c d e "Lariam". The American Society of Health- ... Administration of mefloquine seemed to eliminate the virus from the patient's body and prevented further neurological ... " Retrieved 31 March 2019.. *^ a b c d e Croft, AM (2007). "A lesson learnt: the rise and fall of Lariam and Halfan". ... Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: ...
Individualized Drug Therapy for Patients. Boston: Academic Press. pp. 373-382. ISBN 978-0-12-803348-7.. ... Vardanyan, Ruben; Hruby, Victor (2016). "Chapter 32: Antimicobacterial Drugs". Synthesis of Best-Seller Drugs. Boston: Academic ... Side Effects of Drugs Annual. A worldwide yearly survey of new data in adverse drug reactions. 33: 509-540. doi:10.1016/B978-0- ... Analytical Profiles of Drug Substances. Analytical Profiles of Drug Substances. 12: 37-71. doi:10.1016/S0099-5428(08)60163-X. ...
"Patient UK.. *^ Sejben, István; Rácz, András; Svébis, Mihály; Patyi, Márta; Cserni, Gábor (August 2012). "Petroleum jelly- ... This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.. *v ... Retrieved from "" ...
" Patient UK. Archived from the original on 15 September 2015. Retrieved 11 February 2016.. ... Smyth, Hugh D.C. (2011). Controlled pulmonary drug delivery. New York: Springer. pp. Chapter 2. ISBN 978-1-4419-9744-9. .. ... Drugs and other substances can be absorbed, modified or excreted in the lungs.[48][58] The lungs filter out small blood clots ...
In patients with end-stage cancer, death is a very likely outcome and whether the drug is the cause or a bystander is often ... Drug-drug and food-drug interactions may occur, and so-called "natural drugs" used in alternative medicine can have dangerous ... In terms of drugs, adverse events may be defined as: "Any untoward medical occurrence in a patient or clinical investigation ... Patient Safety Network - includes a glossary and articles on adverse effects, drug reactions, medical error, iatrogenesis, ... Fludroxycortide *^ Fludroxycortide *^ Haelan Tape Summary of Product Characteristics ... This dermatologic drug article is a stub. You can help Wikipedia by expanding it.. *v ...
... drug discovery, development and delivery; infectious diseases; natural products; neuroscience; patient safety; ... Specific research programs include: Lipid and polymer-based drug delivery systems, targeted drug delivery, pharmacokinetic ... rational drug use and distribution, socioeconomic and cultural issues related to drug use. Medicinal Chemistry: Research in ... The College reflects the diverse composition of its host city as well as the UIC patients it serves. The UIC Urban Health ...
Henriksson P (1991). "Estrogen in patients with prostatic cancer. An assessment of the risks and benefits". Drug Saf. 6 (1): 47 ... "Drugs@FDA: FDA Approved Drug Products: Estradurin". United States Food and Drug Administration. Retrieved 24 June 2018.. ... Muller (19 June 1998). European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. pp. 455-. ISBN 978-3-7692- ... Deepinder F, Braunstein GD (2012). "Drug-induced gynecomastia: an evidence-based review". Expert Opinion on Drug Safety. 11 (5 ...
Patients may also present with hypothermia. Mechanism[edit]. See also: Alcohol (drug) § Pharmacology ... "Drug and Therapeutics Bulletin. 41 (2): 49-52. doi:10.1136/dtb.2003.41749. PMC 3099359. PMID 21960817.. ... Schuckit, Marc A. (2013). Drug and Alcohol Abuse: A Clinical Guide to Diagnosis and Treatment. Springer Science & Business ... Belenko, Steven; Spohn, Cassia (2014). Drugs, Crime, and Justice. SAGE Publications. p. PT21. ISBN 9781483355429. .. ...
Wortelboer, U.; Cohrs, S.; Rodenbeck, A.; Rüther, E. (2002). "Tolerability of hypnosedatives in older patients". Drugs & Aging ... may also be a drawback with these particular drugs. While addiction does not seem to be an issue with this class of drugs, they ... "Pharmacoepidemiology and Drug Safety. 25 (6): 637-45. doi:10.1002/pds.3951. PMC 4889508 . PMID 26711081. Archived from the ... Best Buy Drugs. Consumer Reports: 3, 8, 11. Archived (PDF) from the original on 9 December 2013. Retrieved 4 June 2013.. ...
Patients taking both drugs achieve only 13% adherence.[73]. Hypertension[edit]. *Hypertension non-compliance (93% in US, 70% in ... Drug withdrawal. References[edit]. *^ a b c d e f World Health Organization (2003). Adherence to long-term therapies: evidence ... Level of drug metabolite in urine. Level lower than expected. 42% ALL. Level of drug metabolites in blood. Level lower than ... Patients can be routinely defined as being 'Adherent Patients' if the amount of medication furnished is at least 80% based on ...
Zamula, Evelyn (June 1991). "A New Challenge for Former Polio Patients". FDA Consumer. Food and Drug Administration. 25 (5).. " ... In the United States, a mechanical heart is used for the first time in a human patient. ...
... even if the patient becomes asymptomatic. If the patient is institutionalised, monitoring of behaviour and serum sodium levels ... It is important to note that the majority of psychotropic drugs (and a good many of other classes) can cause dry mouth as a ... If the patient presents with acute hyponatraemia (overhydration) caused by psychogenic polydipsia, treatment usually involves ... Since primary polydipsia is a diagnosis of exclusion, the diagnosis may be made for patients who have medically unexplained ...
HIV drugs do not cure HIV infection, but the treatment aims at improving the quality of patients´ lives and decreased mortality ... Drug resistant HIV-strains emerge if the virus is able to replicate in the presence of the antiretroviral drugs. NNRTI- ... 25 antiretroviral drugs were available in 2009 for the treatment of HIV infection. The drugs belong to six different classes ... In 1987, the first drug for the treatment of HIV infection was approved by the U.S. Food and Drug Administration (FDA). This ...
"MethylPREDNISolone (Professional Patient Advice)". Retrieved 2019-05-26.. External links[edit]. *Medrol Prescribing ... "Methylprednisolone Use During Pregnancy ,". Archived from the original on 22 December 2016. Retrieved ... "International Drug Price Indicator Guide. Retrieved 8 December 2016.. *^ Hamilton, Richart (2015). Tarascon Pocket ... Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 486. ISBN 9783527607495. . ...
"Management of patients with thrombophilia". Drug and Therapeutics Bulletin. 33 (1): 6-8. 1995. doi:10.1136/dtb.1995.3316. PMID ... High platelet counts can occur in patients with polycythemia vera (high red blood cell counts), and is an additional risk ... A very small segment of patients report symptoms of erythromelalgia, a burning sensation and redness of the extremities that ... it can predispose to thrombosis in some patients. Thrombocytosis can be contrasted with thrombocytopenia, a loss of platelets ...
Copaxone satisfaction and usage data , Monitoring more than 2,100 patients , Drug safety information , MediGuard FDA Copaxone ... A 15-year followup of the original trial compared patients who continued with glatiramer to patients who dropped out of the ... 020622 at Drugs@FDA Ford C, Goodman AD, Johnson K, et al. (March 2010). "Continuous long-term immunomodulatory therapy in ... Myelin basic protein is the antigen in the myelin sheaths of the neurons that stimulates an autoimmune reaction in patients ...
The goal of such tailored therapy is that patients can be spared the toxicity and side effects of drugs that they do not ... "New drug provides alternative for post-menopausal patients". Lethbridge Herald. Lethbridge, Alberta, Canada. 27 June 2000. p. ... Habib, Marlene (4 April 1997). "New Drug Offers Patients Hope". Brandon Sun. Brandon, Manitoba, Canada. p. 11. Retrieved 2 ... The drug also prevented metastasis of the cancer to other regions of the body. Results from this clinical study were published ...
... and drug-drug interactions. PRIMA-eds is an algorithm that takes many patient factors into its calculations and can offer ... 15% of older adults are potentially at risk for a major drug-drug interaction. When a new drug is prescribed, the risk of ... Patients at greatest risk for negative polypharmacy consequences include the elderly, psychiatric patients, patients taking ... "Trends in polypharmacy and potential drug-drug interactions across educational groups in elderly patients in Sweden for the ...
... Retrieved 2015-12-06. "Alverine capsules - Spasmonal, Audmonal. Side effects; dosage , Patient". Patient. ... Alverine is a drug used for functional gastrointestinal disorders. Alverine is a smooth muscle relaxant. Smooth muscle is a ... The drug was firstly authorized for marketing on 03/06/2014. The marketing authorisation holder is Dr. Reddy's Laboratories (UK ... Women who are pregnant or breast-feeding should follow the instruction of doctors for the drug. The side effects of alverine ...
"Metronidazole". "Metronidazole". Drug Information Portal. U.S. National Library of Medicine. Pharmacy and ... Common adverse drug reactions (≥1% of those treated with the drug) associated with systemic metronidazole therapy include: ... Treatment for both the infected patient and the patient's sexual partner is recommended, even if asymptomatic. Therapy other ... "Metronidazole Use During Pregnancy ,". Archived from the original on 1 January 2017. Retrieved 1 ...
Staff (29 January 2013) FDA approves new orphan drug Kynamro to treat inherited cholesterol disorder U.S. Food and Drug ... the choice of an agent depends on the patient's cholesterol profile, cardiovascular risk, and the liver and kidney functions of ... They are called lipid-lowering drugs. These are drugs which lower the level of lipids and lipoproteins in blood. ... Hypolipidemic agents, cholesterol-lowering drugs or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are ...
All general psychiatrists are expected to be able to treat geriatric patients and many may see mainly geriatric patients but ... and a large number of concurrent medications and potential drug interactions. Within this broad scope of practice, geriatric ... Most geriatric psychiatrists require a referral from a family physician with whom they will share the care of the patient. In ... For many of these patients, their first encounter with mental health care occurs at an advanced age. A specific set of ...
For Alzheimers patients and their families, desperate for an effective treatment for the epidemic disease, theres hope from ... The third study drug could be Lillys BACE inhibitor, now in midstage testing in Alzheimers patients. The company expects by ... The key issue for all these drugs will be what side effects they cause, because patients would take them for many years. ... After safety testing of the drug MK-8931 in about 200 patients, the 78-week study, known by the acronym EPOCH, will quickly ...
A new drug that revs up the immune system to attack cancer cells extended the lives of people with advanced melanoma by an ... Patients have few treatment options. Chemotherapy drugs used to treat advanced melanoma shrink only about 15% of tumors. ... New Drug Extends Lives of Melanoma Patients. Study Shows Ipilimumab Helps Immune System Fight Deadly Skin Cancer ... In the meantime, the drug is available "on a compassionate basis" at many medical centers nationwide, so some patients may be ...
People with advanced liver cancer will not have access to the drug sorafenib after the National Institute for Health and ... It is particularly frustrating that cancer patients in the UK are unable to access this drug when it is routinely available ... as a large international trial has shown the drug to help patients with liver cancer to live longer. ... People with advanced liver cancer will not have access to the drug sorafenib after the National Institute for Health and ...
Patients leaving hospital may be being put at risk of harmful reactions to drugs due to poor communication between hospitals ... Patients leaving hospital may be being put at risk of harmful reactions to drugs due to poor communication between hospitals ... Prescribing errors and a failure to review medication after a patient leaves hospital are known to cause harm to patients every ... But the CQC said GPs were also at fault for not sharing data when patients were first admitted to hospital. ...
Gout sufferers with major pre-existing heart disease face a higher risk of death if they are treated with the drug febuxostat, ... Food and Drug Administration when the drug was approved in 2009. At the time, there was evidence suggesting that the drug was ... Most patients didnt stay on either drug - 57.3 percent stopped taking febuxostat and 55.9 percent discontinued their ... This study will define cardiovascular safety of these drugs in lower risk patients." ...
Ebola drug development is facing hurdles, but vaccine trials are moving at unprecedented rates, with trials that usually take ... Cite this: Ebola Drug Development Slowed by Lack of Patients - Medscape - Jun 05, 2015. ... Only seven patients are enrolled in the trial so far. Even if more patients become available, supplies are limited, with only ... Priority Drugs Among them is ZMapp (Mapp Biopharmaceutical, Inc), a drug cocktail comprising three monoclonal antibodies made ...
... the first evidence that a long-standing drug-supply problem probably has affected cancer treatment results in specific patients ... Young cancer patients who couldnt get a key medicine because of a national drug shortage were more likely to suffer a relapse ... Young cancer patients who couldnt get a key medicine because of a national drug shortage were more likely to suffer a relapse ... Doctors compared results among 181 Hodgkin lymphoma patients who received the drug to 40 others who were given a different ...
Chimerixs drug brincidofovir was approved for emergency use in treating Ebola patients, and is now being used on a case in ... Other Ebola patients soon could also be receiving the drug as a result of the Food and Drug Administrations decision to ... ZMapp was initially used in a few patients, but the supply of the drug produced by MAP Pharmaceuticals has run out. Tekmira ... because of the ethical issues of evaluating the drug in a placebo-controlled study, where some patients suffering from Ebola ...
... is already approved for treating such patients -- based on earlier results showing it can delay the progression of their cancer ... The drug, called Kisqali (ribociclib), is already approved for treating such patients -- based on earlier results showing it ... And, he added, it argues for giving the drug as a "first-line or second-line" treatment to these patients. ... "Is this an effect of the drug, or a drug-class effect?" Norton said. ...
Drug company Pfizer has announced it will extend its donations of antibiotics to treat the debilitating eye disease trachoma ... "This horrible disease can lead to enormous pain and eventual blindness, but can be easily prevented and treated with this drug ... Pfizer initially said its donation of the drug Zithromax would end in 2020, the target for the worldwide elimination of the ... Now it has said that the drugs will be available until 2025 "to help all endemic countries reach their targets". ...
... with 256 patients using it at a cost of £3.1 million to the medicines budget. This would have increased to 391 patients at a ... But drugs company Roche said the ruling was a "devastating blow" to Scottish breast cancer sufferers and pointed out National ... The agency, which decides which new drugs should be provided on the NHS, said it had rejected the treatment over concerns about ... Breast cancer sufferers in Scotland have been denied routine access on the NHS to an "innovative" new drug despite it being ...
... reduced the incidence of pulmonary flare-ups in cystic fibrosis patients by 55% compared with a placebo, trial results show. It ... Researchers are trying to develop drugs that would help bring that protein to the surface. Once a patient is on such a drug, ... The study of 161 patients also found that patients who took the drug saw their lung function improve 10.4% and gained nearly 6 ... The drug, called ivacaftor, cleared her lungs and allowed her to add a healthy 15 pounds to her 5-foot, 100-pound frame. On the ...
Despite big increases in heart patients on medication, most still have high blood pressure and nearly half have high ... but bad habits such as overeating and smoking are undermining the drugs, a new study says. ... European heart patients are taking more medication than ever before to lower their blood pressure and cholesterol, ... Researchers also found that the numbers of patients taking drugs to lower their cholesterol was seven times higher in 2006-2007 ...
... is for treating anorexia associated with weight loss in patients with AIDS and for treating nausea and vomiting associated with ... Cite this: FDA Clears Oral Cannabis Drug for AIDS, Cancer Patients - Medscape - Jul 06, 2016. ... Patients with a history of substance abuse or dependence should be assessed for risk for abuse or misuse prior to prescribing ... Such patients should be monitored for the development of associated behaviors or conditions, according to the company. If ...
... ruling that federal approval of a prescription drug does not provide a shield against lawsuits ... Supreme Court rules patients can sue drug makers. The justices, acting in a Vermont case, reject the Bush administrations ... Lawsuits not only compensate injured individuals, but they "uncover drug hazards and provide incentives for drug manufacturers ... ruling that federal approval of a prescription drug does not provide a shield against lawsuits from injured patients. ...
Study finds drug approved to treat metabolic acidosis intravenously might serve as an aerosol to reduce airway surface liquid ... The drug showed enhanced ability to kill bacteria in the airways of pigs and mucus samples from human patients with cystic ... "Cystic fibrosis patients may benefit from repurposed approved drug." Medical News Today. MediLexicon, Intl., 3 Jun. 2016. Web. ... Paddock, C. (2016, June 3). "Cystic fibrosis patients may benefit from repurposed approved drug." Medical News Today. Retrieved ...
However, 11 of the patients who received the drug left the trial before completion, some citing side effects that included ... After 32 weeks of treatment, 18 of the 29 patients (62 percent) who were randomized to receive the drug experienced significant ... It is these patients with severe asthma with fungal sensitization, or "SAFS", as the researchers named the syndrome, who are ... Some patients with severe asthma who also have allergic sensitivity to certain fungi enjoy great improvements in their quality ...
Total prescription drug spending. Spending on prescriptions by the Part D drug plans and their patients totaled $2,670 per ... Effective drug use was studied for three groups of Part D beneficiaries: patients who had a heart attack, patients ages 65-75 ... Drug therapies proven to be effective for patients who have suffered heart attacks, have diabetes, or have broken a bone; ... Patients in Manhattan (36%) were more than twice as likely to fill a prescription for a brand-name product than patients in La ...
Surgeons in Southampton are trialling a new drug based on a chemical found in broccoli to try to improve outcomes for brain ... "Surgeons trial new drug to help brain haemorrhage patients." Medical News Today. MediLexicon, Intl., 24 May. 2016. Web.. 17 Sep ... The drug is being developed by Evgen Pharma for breast cancer patients as a way of overcoming treatment resistance and relapse ... and his team will assess the effect of experimental drug SFX-01 on patients who have received treatment for a bleed on the ...
A drug that cuts off the blood supply feeding tumours may boost the survival of patients with glioblastoma multiforme (GBM), a ... A drug that cuts off the blood supply feeding tumours may boost the survival of patients with glioblastoma multiforme (GBM), a ... Publishing their findings in the Journal of Clinical Oncology, they reveal that out of 35 patients given the drug combination, ... the amount of time that patients can survive without tumour growth if given in conjunction with a standard chemotherapy drug. ...
Kennedy R.D. (1989) Drug Treatment of Hypertensive Geriatric Patients. In: Platt D. (eds) Gerontology. Springer, Berlin, ... Lawson DM, Jick H (1976) Drug prescribing in hospitals: a international comparison. Am J Public Health 66: 644-648PubMed ... A series of eight patients. Arch Intern Med 146: 1355-1357CrossRefGoogle Scholar ... Brown J, Dollery C, Valdes G (1986) Interaction of nonsteroidal anti-inflammatory drugs with anti-hypertensive and diuretic ...
See Patient Experience Data.. Patient partner: An individual patient, caregiver or patient advocacy group that engages other ... Patient-centered: See patient-focused. Patient-centered outcome: An outcome that is important to patients survival, ... Patient-Focused Drug Development Glossary This glossary defines terms that will be used in the series of methodological Patient ... Patient-focused drug development (PFDD) (also referred to as patient-focused medical product development: A systematic approach ...
Health authorities are working to identify people who may have been exposed to a patient with a drug-resistant form of ... Patient with drug-resistant tuberculosis being treated in Maryland. By Dana Ford and Debra Goldschmidt, CNN ... Health authorities are working to identify people who may have been exposed to a patient with a drug-resistant form of ... XDR-TB patients can be cured, but theirs odds are worse than patients with ordinary TB. ...
  • Researchers were frustrated this year by failures of two drugs that targeted amyloid beta - bapineuzumab from Pfizer Inc. and Johnson & Johnson, and solanezumab from Eli Lilly and Co. Both drugs are injected because their large molecules can't pass through the digestive tract into blood vessels. (
  • Researchers are trying to develop drugs that would help bring that protein to the surface. (
  • Researchers interviewed more than 8,500 patients in eight countries. (
  • Researchers also found that the numbers of patients taking drugs to lower their cholesterol was seven times higher in 2006-2007 than in 1995-1996. (
  • The researchers speculate that an aerosol version of Tham and hypertonic saline might be an effective treatment for helping clear mucus and infection in the airways of CF patients. (
  • For their study, the researchers investigated the effect of a drug called tromethamine (which they refer to as Tham) on the acidity of the ASL and its ability to kill bacteria. (
  • It is these patients with severe asthma with fungal sensitization, or "SAFS", as the researchers named the syndrome, who are most likely to enjoy marked improvement with the antifungal therapy. (
  • In their first look at prescription drug use, Dartmouth researchers also find that the health status of a region's Medicare population accounts for less than a third of the variation in total prescription drug use, and that higher spending is not related to higher use of proven drug therapies. (
  • Researchers at Duke University found that Bevacizumab (Avastin), a drug that stunts the growth of blood vessels that feed a tumour's growth and spread, may increase the amount of time that patients can survive without tumour growth if given in conjunction with a standard chemotherapy drug. (
  • FRIDAY, Aug. 11, 2017 (HealthDay News) -- Scientists experimenting with the marijuana compound cannabidiol as an epilepsy treatment must evaluate any interactions with other anti-seizure drugs patients are taking, researchers report. (
  • The researchers also found that adult patients taking clobazam reported feeling sedated more often. (
  • The drug also had a favorable safety profile compared with efavirenz, which is known for sometimes-difficult central nervous system side effects, researchers on the so-called THRIVE and ECHO trials reported. (
  • Patients with hepatitis C who suffer from advanced stages of liver disease have renewed hope, thanks to findings by researchers who have discovered that a new drug significantly reduces their risk of death and need for transplantation. (
  • The research team, led by clinical researchers at Intermountain Healthcare's Intermountain Medical Center in Salt Lake City, studied nearly 1,900 hep C patients and found that the number of patients needing transplants was reduced by 40 percent after they were given a regimen of the drug, sofosbuvir. (
  • Researchers studied longitudinal data to learn the impact sofosbuvir had in treating patients with advanced stages of cirrhosis. (
  • A DNA methyltransferase inhibitor that's effective against myelodysplastic syndrome also shows early promise in higher-risk older patients with acute myeloid leukemia (AML), researchers found. (
  • The researchers had previously studied decitabine using a 10-day schedule and found "promising" clinical activity in a similar cohort of older AML patients. (
  • The standard therapy for older AML patients unfit for intensive chemotherapy (low-dose cytarabine, Cytosar-U, DepoCyt) produced complete response in only 17% of patients with a median survival of three to four months, the researchers cited from a prior trial. (
  • Washington, Dec 18 (ANI): Researchers have suggested that cystic fibrosis (CF) patients with normal to mildly impaired lung function may benefit from a new investigational drug designed to help prevent formation of the sticky mucus that is a hallmark of the disease. (
  • Called denufosol, the investigational medication can be given early in the CF disease process, and may help delay the progression of lung disease in these patients, the researchers found. (
  • Researchers enrolled 352 cystic fibrosis patients 5 years of age or older, and enrolled them to receive either inhaled denufosol or placebo three times daily for 24 weeks, followed by a 24-week open-label period when all patients received denufosol. (
  • At the end of the 24-week period, researchers determined patients who received denufosol had better lung exhalation rates than those in the placebo group, whose exhalation volumes remained relatively unchanged from the start of the study. (
  • The drug, canagliflozin, also led to clinically meaningful drops in blood pressure and weight loss, both of which should be beneficial for diabetics at an elevated risk of heart problems, researchers said. (
  • As with prior canagliflozin studies, researchers did not see signs of the liver problems that contributed to an FDA rejection of dapagliflozin, a drug from AstraZeneca Plc and Bristol-Myers Squibb Co that belongs to the same SGLT2 class. (
  • The patients were followed for about 51 months, and during that time the researchers found that survival was not worse for patients who just took sunitinib. (
  • People who undergo kidney removal must heal before they can start targeted cancer drugs, often losing weeks they don't have to spare, the researchers noted. (
  • The researchers concluded that anti-PD-1 therapy may be considered for FDA approved indications in patients with HIV who are on antiretroviral therapy and have a CD4 count above a certain threshold (100 cells per microliter of blood). (
  • However, researchers are still uncertain how the drug works and exactly what it is affecting in the brain, which is the primary concern about its use. (
  • Researchers admit that the drug needs a lot more study before it could become a standard treatment for depression. (
  • In patients on the combination therapy, researchers found no progression of the cancer for an average of 7.3 months, as compared to 5.8 months for those treated with the single drug. (
  • Washington: Seeking new treatments to slow the progression of Alzheimer's disease, researchers found the blood pressure drug nilvadipine increased blood flow to the brain's memory without affecting other parts of the brain. (
  • Neither researchers nor the participants knew who received the drug or the placebo that was evenly divided among the two groups. (
  • Now, by sequencing the whole genomes of over 1,000 isolates of mycobacteria from 517 individuals attending CF specialist centres in Europe, the US and Australia, researchers have demonstrated that the majority of CF patients have acquired transmissible forms of M. abscessus that have spread globally. (
  • Using a combination of cell-based and mouse models, the researchers showed that the recently-evolved mycobacteria were more virulent, likely to cause more serious disease in patients. (
  • Researchers compared Avastin generically called bevacizumab to a placebo in more than 600 patients with glioblastoma and found similar survival rates. (
  • That was based on studies that showed apparent improvements when researchers looked at scans of the patients brains. (
  • The collaboration of faculty from dentistry and pharmacy to study potential cancer drugs for their effectiveness in treating a herpes virus is a classic example of what researchers say is a major strength of U-M: the ease of teaming with others outside their discipline to find new approaches to questions bigger than any one way of answering them. (
  • Researchers at Indiana University School of Medicine, led by Brenna McDonald, Psy.D., associate professor of radiology and imaging sciences, and Thomas McAllister, M.D., chairman of the Department of Psychiatry, compared the effectiveness of two forms of cognitive therapy with and without the use of methylphenidate, a drug used to treat attention-deficit/hyperactivity disorder. (
  • A combination of the stimulant drug methylphenidate with a process known as cognitive-behavioral rehabilitation is a promising option to help people who suffer from persistent cognitive problems following traumatic brain injury, researchers at Indiana University School of Medicine have reported. (
  • Only 7 percent of smokers picked up a prescription for a smoking cessation drug during the 90 days following their heart attacks, researchers found. (
  • From studying the biology of treatment targets in the lab, to developing new cancer drugs, our researchers are working hard to ensure more people survive cancer. (
  • People with heart failure and normal cholesterol may benefit from cholesterol-lowering drugs called statins, researchers report in today s rapid access issue of Circulation: Journal of the American Heart Association. (
  • To exclude statins well-known cholesterol-lowering properties, which may improve heart failure caused by coronary artery disease, the researchers limited the study to patients with idiopathic dilated cardiomyopathy, meaning their heart failure was due to viral or genetic causes rather than to blockage of heart vessels caused by high cholesterol. (
  • Researchers studied 51 patients in Japan, where lead author Koichi Node, M.D., Ph.D., is a professor of medicine in the cardiovascular division at Saga Medical School, Saga, Japan. (
  • However, researchers caution that larger studies with hard endpoints are needed before statins can be recommended to treat patients with this form of chronic heart failure. (
  • A three-drug cocktail could be "life-changing" for patients with cystic fibrosis, researchers reported Thursday. (
  • Nonetheless, the findings are exciting for researchers who treat cystic fibrosis, a rare genetic disease that causes lung and digestive problems and shortens the lives of patients. (
  • Researchers tested two experimental Vertex drugs among patients taking another dual combination of the drugs lumacaftor and tezacaftor. (
  • The value of the third drug is that it helps correct a genetic malfunction by adding a synergistic effect to the dual combinations, the researchers said. (
  • Researchers learned last week that they have been given a green light by the Drug Enforcement Administration to launch a clinical trial for MDMA in an effort to size up the drug's potential in assisting patients with life-threatening conditions come to grips with their end of life. (
  • Alzheimer's patients and their families, desperate for an effective treatment for the epidemic disease, there's hope from new studies starting up and insights from recent ones that didn't quite pan out. (
  • It's the first time any treatment has been shown to improve survival times in metastatic melanoma patients in rigorous late-stage clinical testing, he says. (
  • Patients have few treatment options. (
  • Tumors shrink in one in four patients with advanced melanoma who get this treatment, but only about 6% to 11% live for five years. (
  • All patients had failed to be helped by previous treatment. (
  • Fourteen patients (2.1%) in the study died because of reactions to the treatment, seven from immune system problems. (
  • The unexpected scarcity of human patients left to enroll in clinical trials - as opposed to the millions who as recently as last fall had been projected to be infected - adds to a series of stumbling blocks that have hindered efforts to develop an effective treatment. (
  • Even if more patients become available, supplies are limited, with only 15 courses of treatment produced every 6 weeks. (
  • Young cancer patients who couldn't get a key medicine because of a national drug shortage were more likely to suffer a relapse than others who were able to get the preferred treatment, doctors report. (
  • It's the first evidence that a long-standing drug-supply problem probably has affected cancer treatment results in specific patients. (
  • Reasons include manufacturing and contamination problems, plant shutdowns, and fewer makers and lower profits for certain drugs, especially generics infused during surgery or cancer treatment. (
  • But proving that the swaps led to poorer results has been tough, especially for cancer patients whose disease and response to treatment vary so much. (
  • Only 75 percent of those given the substitute drug stayed free of cancer for two years versus 88 percent who received the preferred treatment. (
  • After eight weeks of treatment with the preferred drug, "she was doing wonderfully," said her mother, Katie Alonzo. (
  • And, he added, it argues for giving the drug as a "first-line or second-line" treatment to these patients. (
  • Novartis says that as a precaution, Kisqali patients should have their heart activity checked before and during treatment. (
  • The agency, which decides which new drugs should be provided on the NHS , said it had rejected the treatment over concerns about its long-term survival benefits and not because of cost. (
  • Perjeta is used in combination with another drug and chemotherapy for the treatment of "locally advanced, inflammatory, or early stage breast cancer. (
  • According to the submission by Roche to the SMC, 426 women in Scotland would have been eligible for treatment in its first year, with 256 patients using it at a cost of £3.1 million to the medicines budget. (
  • He added: "It adds further insult to injury that patients in England, Wales and Northern Ireland receive access to this innovative treatment. (
  • The US Food and Drug Administration (FDA) has approved dronabinol oral solution ( Syndros , Insys Therapeutics, Inc) for the treatment of anorexia associated with weight loss in patients with AIDS and for nausea and vomiting associated with cancer chemotherapy in patients who fail to respond adequately to conventional antiemetic treatments, according to a company news release. (
  • New research suggests that a drug already approved for the treatment of metabolic acidosis - where the body has too much acid - could be repurposed and used to treat airway disease in patients with cystic fibrosis. (
  • After 32 weeks of treatment, 18 of the 29 patients (62 percent) who were randomized to receive the drug experienced significant improvements on their Asthma Quality of Life Questionnaires, and in runny nose and morning lung function. (
  • Diederik Bulters, a consultant neurosurgeon at Southampton General Hospital, and his team will assess the effect of experimental drug SFX-01 on patients who have received treatment for a bleed on the brain known as a subarachnoid haemorrhage (SAH), which is a type of stroke . (
  • The drug is being developed by Evgen Pharma for breast cancer patients as a way of overcoming treatment resistance and relapse. (
  • Despite the need, there have been no significant clinical developments since the introduction of nimodipine more than 20 years ago, so we are absolutely delighted to offer patients the opportunity to be involved with this exciting new treatment. (
  • It also follows our unit's landmark trial of nimodipine in the 1980s and we now hope to be able to continue this history of research into the condition and develop a further treatment for patients. (
  • Seven weeks after arriving, the patient -- who also spent time in Missouri and Tennessee -- sought treatment and was diagnosed with active tuberculosis. (
  • It can either develop in someone receiving treatment for active TB, when anti-TB drugs are misused, or it can spread from a patient already ill from XDR-TB. (
  • One of the patients, who ranged in age from 55 to 79, died, but the other three survived after intensive treatment in hospital emergency departments and intensive care units. (
  • These are serious, debilitating, life-shortening illnesses, and as the currently available treatments have high failure rates, psychedelics might offer alternative treatment strategies that could improve the well-being of patients and the associated economic burden on patients and society," they wrote in the journal Nature Neuroscience. (
  • And she doesn't remember how many patients she may have put at risk before getting into treatment. (
  • Patients have been left with an impossible choice: Take a drug that may be tainted, or discontinue treatment. (
  • It was later approved for treatment of those cancers in earlier stages, too, based on studies that had tested it in patients for 12 months. (
  • Dr. Harold Burstein, a breast cancer expert at Dana-Farber Cancer Institute in Boston, said shorter treatment may increase access to the drug in countries where many women can't afford it now, but that in the U.S., 'my guess is that people will continue to aim for a year of treatment' because of lingering concerns that longer use is better, as a smaller, previous study suggested. (
  • Dr. Jennifer Litton, a breast specialist at MD Anderson Cancer Center in Houston, said Herceptin was a true breakthrough, but scaling back treatment whenever possible is just as important to patients. (
  • Occasionally, they may be receiving inappropriate drugs or doses - or no treatment at all. (
  • The drug under study is currently approved only for the treatment of mild to moderate dementia from Alzheimer's disease. (
  • General practitioners may be asked to prescribe unlicensed or off label drugs by specialists or may consider initiating such treatment themselves. (
  • About 80 percent of the drugs in short supply are generic medicines for injection, including the chemotherapy treatment drug Doxil, WFTV reports. (
  • Only one of the patients who responded to the treatment has relapsed, Le said. (
  • Keytruda, currently approved by regulators for the treatment of advanced melanoma, is among the first in a new class of drugs that aim to trigger the body's immune system to attack a wide variety of tumors. (
  • Explain that the new non-nucleoside reverse transcriptase inhibitor rilpivirine had noninferior efficacy to efavirenz in viral suppression in treatment-naive, HIV-infected patients with fewer adverse effects. (
  • The recently approved anti-HIV drug rilpivirine (Edurant) is a new option for people starting treatment for the virus, according to investigators on two randomized controlled trials. (
  • The drug was noninferior to efavirenz (Sustiva), the preferred option for initial treatment of HIV infection, in suppressing viral replication, the industry-supported trials showed. (
  • The downside of rilpivirine, both studies found, was that it appeared slightly less effective than efavirenz when patients began treatment with a plasma viral load above 100,000 copies of HIV RNA per milliliter. (
  • In both studies, the primary objective was to show that the drug was noninferior to efavirenz in the percentage of patients with a plasma viral load of less than 50 copies per milliliter after 48 weeks of treatment. (
  • Caution interested patients that the study included no control group, so it is unclear how the treatment regimen used would really measure up to other regimens. (
  • A different decitabine regimen trial with an induction/consolidation approach of five days of treatment per cycle in a patient population similar to that in Croce's study yielded a 25% overall response rate, with 24% complete remissions and a median overall survival of 7.7 months. (
  • The multi centre double blind, randomised, parallel group study in 58 patients assessed the efficacy , safety and tolerability of Sativex®, a whole plant medicinal cannabis extract, compared with placebo for the treatment of pain caused by Rheumatoid Arthritis. (
  • While early detection of pancreatic cancer is difficult and only 20 to 30 percent of patients can have the cancer removed through surgery, administration of S-1 is expected to be a new recurrence prevention treatment for those who undergo surgery. (
  • Many patients continue to suffer progressive loss of lung function despite treatment of complications. (
  • The company said it would assess the potential for the treatment, Gocovri, in MS patients before determining its continued investment in the program. (
  • While a higher dose of the treatment taken at bedtime improved walking speed among patients with multiple sclerosis, it did not have any significant effect on secondary goals. (
  • The trial tested two different doses of the treatment and compared it with a placebo: patients who took the higher 274 mg dose showed a significant improvement 12 weeks after treatment. (
  • But Lotronex was the first drug made specifically to treat chronic diarrhea caused by irritable bowel syndrome, and these patients and their doctors say there is no other drug for them to switch to, no other effective treatment for their condition. (
  • Data from a limited number of patients studied (single case report) suggest that captopril may be beneficial for the treatment of hypertension secondary to scleroderma renal crisis [Collins . (
  • This treatment does not save lives, but it can prolong the lives of patients and also improve the quality of the time they have left. (
  • An experimental treatment for type 2 diabetes developed by Johnson & Johnson proved effective at reducing blood sugar in patients on long-term insulin therapy and at high risk for heart problems, according to a study presented on Tuesday. (
  • After 18 weeks of daily treatment, A1C - a common measure of blood sugar - was reduced by 0.65 percent in patients taking 100 mg of canagliflozin and by 0.73 percent at 300 mg versus virtually no change on placebo. (
  • The results from this sub study suggest that canagliflozin could provide an important new treatment option for higher risk adult patient with type 2 diabetes. (
  • 2 In 1994 treatment was started in a patient with pulmonary tuberculosis who was lost to follow-up. (
  • Our study suggests that in patients with heart failure and atrial fibrillation , catheter ablation is an effective alternative treatment that can help patients avoid or discontinue this drug to reduce the risk of these long-term side effects," said Di Biase, who is also a senior researcher at St. David's Medical Center in Austin, Texas. (
  • One patient who has benefited from the pioneering treatment is Mike Simpson. (
  • 40 per cent of patients had all signs of their terminal lymphomas removed from their body just 15 months after treatment. (
  • One patient with lung cancer had a complete response to treatment, and activity was also noted in important HIV-associated cancers, including non-Hodgkin lymphoma, Kaposi sarcoma and liver cancer. (
  • If you have patients that are likely to seriously injure themselves or kill themselves within a short period of time, and they've tried the standard treatments, how do you not offer this treatment? (
  • Sanacora and others feel that if the treatment can save a life, there is nothing unethical about prescribing the drug. (
  • This treatment undoubtedly will be evaluated carefully by the U.S. Food and Drug Administration and, if approved, will give women with ovarian cancer another much needed option, Monk added. (
  • Such a study is often the last step before a drug is reviewed by a regulatory agency like the FDA for approval as a safe, effective treatment. (
  • For those who had relapsed more than six months after the first-line therapy, the median progression-free time was 9.2 months for the combination treatment, as compared to 7.5 months for the other patients. (
  • Providers can monitor patient medication usage and ensure adherence to treatment. (
  • For a clinician to safely continue treatment and prescribe more medications, it is critical to understand the full scope of medication therapy the patient is taking from all of their providers. (
  • But gratitude is tinged with worry, because the Food and Drug Administration is considering the unusual step of revoking its approval of Avastin as a treatment for metastatic breast cancer. (
  • This is a boon to all those patients who do not react to Gleevec which is the treatment for Leukemia. (
  • A new genetic test of colon cancer tumors is able to predict with accuracy whether a patient will respond to treatment with the drug Erbitux, which blocks tumor growth. (
  • Even though no medical treatment is without risk, getting treatment for high blood pressure could be important to maintain brain health in patients with Alzheimer's disease," said study lead author Jurgen Claassen. (
  • The Food and Drug Administration has given its approval to use the drug in recurrent cases, when a patient already has gone through typical treatment and has a growing tumor. (
  • It is licensed by ViroPharma, which announced today that maribavir is headed for phase 2 clinical trials for the treatment of cytomegalovirus infection in stem cell transplant patients. (
  • But advances in treatment of HIV and AIDS patients temporarily slowed interest in the compound and development work ceased. (
  • An off-patent anti-viral drug, Favipiravir, originally discovered by Fuji Pharma in Japan, has shown promise in clinical trials for treatment of COVID-19 patients, especially in mild and moderate cases. (
  • Pharmaceutical firm Cipla is all set to launch Favipiravir, developed by the Council of Scientific and Industrial Research (CSIR) in a cost-effective process, for the treatment of COVID-19 patients, according to an official statement on Thursday. (
  • Deerfield, Ill., July 5 (Reuters) -- The US Food and Drug Administration approved the antifungal drug AmBisome for the treatment of cryptococcal meningitis in HIV-infected patients, Fujisawa Healthcare Inc. and Gilead Sciences Inc. said Wednesday. (
  • BOSTON - The criminal investigation of insurance fraud by a Brookline doctor has caused the collapse of his statewide chain of drug treatment clinics. (
  • The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. (
  • But the drugs, which held promise for replacing standard chemotherapy treatment, shrank tumors in only 15 to 20 percent of patients. (
  • The trial showed that treatment with the oral FGFR inhibitor erdafitinib (ERDA) was well-tolerated and achieved a robust response for patients with metastatic urinary tract cancers that harbor mutations in the FGFR3 gene. (
  • The targeted therapy also appeared effective in a subset of patients for whom immunotherapy had previously failed, suggesting ERDA may provide benefit for patients without further treatment options. (
  • Given the limited treatment options for urinary tract cancer, we still have a long way to go to benefit our patients," Siefker-Radtke says. (
  • DTG is a first-line drug used for HIV treatment in many countries with a high burden of tuberculosis. (
  • Triferic is a novel iron compound that has a unique mode of action in that it is delivered to the patient via their dialysis treatment as opposed to intravenous delivery. (
  • All these factors considered, the only significant one was the patients' duration of treatment. (
  • The study is significant because most private and government insurance programs only reimburse the patient for 30 days of addiction treatment. (
  • Aftercare is crucial once an individual has completed drug or alcohol treatment and is in recovery. (
  • Our study shows that the absence of such treatment after 30 days significantly reduces the chances of the patient maintaining their sobriety ,' says Akikur Mohammad, M.D., who led the study. (
  • The Affordable Care Act was the first significant federal legislation to recognize alcohol and drug addiction as a disease and to fund its treatment. (
  • FDA is interested in obtaining patient input on the impact of alopecia areata, including on daily life, patient views on treatment approaches, and decision factors taken into account when selecting a treatment. (
  • Medical professionals are scrambling to meet the growing demand for emergency room treatment, but they're hampered by the lack of a quick and easy test to screen patients for these "designer" drugs. (
  • He asked to be relocated to the Kenema Government Hospital to serve on the Ebola treatment ward after he heard reports that patients were being abandoned when health workers died from the virus. (
  • There is no cure for Ebola but with treatment of the symptoms, and proper hydration, patients have a chance of survival. (
  • There is a need to better understand "treatment resistance" and develop tools to reduce this rate of nonresponse, and by doing so, improve patients' lives. (
  • The Depression Center sees about 600 patients each year who are resistant to treatment for depression or bipolar disorder. (
  • Patients with this genetic variation who are treated with carbamazepine - which may be prescribed for bipolar disorder or epilepsy - should be tested before considering this treatment. (
  • This opens up a new treatment strategy for patients with heart failure, regardless of their cholesterol levels. (
  • ZURICH (Reuters) - Swiss drugmaker Roche's new treatment for advanced skin cancer helps patients live longer and also extends the period in which their disease does not get worse, a late-stage trial has shown. (
  • The folks at MAPS have studied the drug for over the past decade as a potential treatment for post traumatic stress disorder, even while the federal government has become increasingly hell bent on imposing stricter penalties on those who distribute and possess the drug. (
  • Ivacaftor affects a genetic mutation in 4% to 5% of cystic fibrosis patients that prevents a protein called CFTR from allowing enough chloride ions to exit a certain type of cell. (
  • The drug can't yet help the vast majority of cystic fibrosis sufferers: About 90% of them have a mutation in which the protein, once manufactured inside the cell, never even makes it to the cell surface where it is supposed to act as a chloride channel. (
  • It's creating such a sense of hope and optimism for all the cystic fibrosis patients because this approach will work,' said Robert Beall, president and chief executive of the Bethesda, Md.-based Cystic Fibrosis Foundation, which has spent millions funding such research. (
  • The drug showed enhanced ability to kill bacteria in the airways of pigs and mucus samples from human patients with cystic fibrosis. (
  • The drug is different from other CF medications, which primarily treat the symptoms rather than the underlying causes, said Accurso, who is also the director of University of Colorado's cystic fibrosis center. (
  • A multi-drug resistant infection that can cause life-threatening illness in people with cystic fibrosis (CF) and can spread from patient to patient has spread globally and is becoming increasingly virulent, according to new research published today in the journal Science . (
  • Dr Janet Allen, Director of Strategic Innovation at the CF Trust, said: "This paper highlights the risks posed through transmission of multi-drug resistant organisms between people with cystic fibrosis. (
  • They found that adding a third drug to an existing combination of two drugs could improve the symptoms of cystic fibrosis patients, and might even help some of them live longer. (
  • These results represent a major breakthrough in cystic fibrosis therapeutics, with the potential for improving health and possibly survival in all patients who carry the most common CFTR mutation," Dr. Fernando Holguin of the University of Colorado, who was not involved in the studies, said in a commentary published in the New England Journal of Medicine. (
  • The journal is carrying two reports about two experimental cystic fibrosis drugs, both developed by Vertex Pharmaceuticals. (
  • This approach has the potential to treat the underlying cause of cystic fibrosis in approximately 90 percent of patients," Taylor-Cousar and colleagues wrote. (
  • It was the first drug to address the underlying cause of cystic fibrosis symptoms. (
  • Swiss scientists suggested Wednesday that psychedelic drugs like LSD, ketamine and magic mushrooms could be combined with psychotherapy to treat people suffering from depression, compulsive disorders or chronic pain. (
  • Mental illnesses like depression are a growing health problem around the world and Vollenweider and Kometer said many patients with severe or chronic psychiatric problems fail to respond to medicines like serotonin reuptake inhibitors like Prozac or Paxil. (
  • The company aims to request regulatory approval for expanded use of the drug in chronic kidney disease over the next few months, said Mene Pangalos, the head of Astra's biopharmaceuticals research and development. (
  • The company Bristol-Myers Squibb Co at Boston told the press that the drug Dasatinib has led to reduction in the number of patients with Chronic myeloid leukemia (CML). (
  • Dasatinib was tried on all these stages of leukemia patients and the results were Out of the186 patients who are in the chronic stage, 45% of the patients attained complete elimination of the leukemia cells from the marrow. (
  • The toxicity level of Dasatinib is not more than Gleevec and it has to be brought in to the market for commercial use as the statistics show that in the current year the number of chronic CML patients to be 4600. (
  • In these patients, CMV can lead to conditions such as pneumonitis or hepatitis, or to complications such as acute or chronic rejection of a transplanted organ. (
  • Doctors at the North Shore-LIJ Health System, on Saturday, will present late-breaking data showing that an investigational drug Triferic is well tolerated and effective in treating iron deficiency in patients with chronic kidney disease undergoing dialysis. (
  • When chronic kidney failure reaches an advanced stage, dangerous levels of fluid, electrolytes and wastes can accumulate in the body, and a patient will need to undergo hemodialysis (dialysis) - a machine that filters wastes, salts and fluid from the blood. (
  • Up until now, iron deficiency in chronic kidney disease patients who undergo dialysis has been treated almost exclusively with intravenous iron, which injects a large amount of iron directly into the blood stream. (
  • Statins have already been shown to decrease the incidence of chronic heart failure in patients with coronary artery disease and high cholesterol. (
  • The Ebola victim being treated in Dallas is now receiving an experimental drug after federal authorities gave the go-ahead for its use in emergency cases, the hospital said Monday. (
  • But since she started taking an experimental drug as part of a closely watched clinical trial, her outlook has changed. (
  • CNN reported last August that "the Food and Drug Administration put the experimental drug esketamine (also known as ketamine) on the fast track to official approval for use in treating major depression. (
  • William Pooley, the first Briton to contract Ebola during this outbreak, has been given the experimental drug ZMapp. (
  • The experimental drug Mr Pooley is receiving was previously given to two American aid workers who have now recovered from the virus. (
  • The Roche/Plexxikon drug and ipilimumab, an experimental drug for advanced melanoma being developed by U.S. group Bristol-Myers Squibb, are providing the possibility of hope for patients who have previously had few options. (
  • That may not sound like much, but given that "average survival [for metastatic melanoma ] is six to nine months, on average, an additional four months is a very large difference for these patients," says one of the study's leaders, Steven O'Day, MD. He is director of the melanoma program at the Angeles Clinic and Research Institute in Los Angeles. (
  • A drug that cuts off the blood supply feeding tumours may boost the survival of patients with glioblastoma multiforme (GBM), a deadly form of brain cancer . (
  • By comparison, in a prior trial, just 10% of poor-risk patients treated nonintensively survived to one year while intensive chemotherapy did slightly better, with 30% one year survival. (
  • To improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction manifested as an ejection fraction of ≤40%, and to reduce the incidence of overt heart failure and subsequent hospitalizations for heart failure in these patients. (
  • Reuters) - AstraZeneca said its Farxiga drug improved survival chances for patients suffering from kidney disease, underscoring the medicine's role outside its established field of diabetes. (
  • But given the expense of Avastin at least $5,000 a month and the fact that survival isn t better for those treated right away with the drug, it isn t likely that doctors will continue to use it in those cases, he said. (
  • 1 The appropriateness of such prescribing is uncertain, and a high rate of adverse drug reactions has been observed in children prescribed such drugs. (
  • In THRIVE, 4% of rilpivirine patients and 7% of those getting efavirenz stopped therapy owing to adverse events. (
  • Both groups had similar numbers and types of adverse events, with the denufosol patients experiencing significantly fewer headaches and lower rates of sinusitis and runny nose. (
  • Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. (
  • Even modest amounts of the drug can have various adverse side effects such as nausea, vomiting, numbness, depression, amnesia, and even respiratory failure. (
  • Even then, these patients are closely monitored for adverse side effects, addiction, and more. (
  • 27 This adverse event has been the subject of a review by the US Food and Drug Administration and has captured the attention of authoritative bodies around the world. (
  • Black box warnings from the Food and Drug Administration (FDA) about adverse drug effects highlight the value of pharmacogenomic testing. (
  • Varenne O, Cook S, Sideris G et al (2018) Drug-eluting stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial. (
  • NEW ORLEANS, March 19, 2018 -- Drug overdoses are taking a huge toll on public health, with potent synthetic drugs posing a particular threat. (
  • Lawsuit: Memphis nursing home allegedly drugged patients to make them easier to manage A lawsuit unsealed in federal court in Memphis alleges that a Raleigh-area nursing home gave heavy anti-psychotic drugs to residents to keep them "docile. (
  • In return, the company's president, Damion Smith, allegedly sent residents to Kishore for drug testing. (
  • SFX-01 will be taken in capsule form, either by mouth or nasogastric tube, in 300mg doses in combination with nimodipine during the trial, which will involve 90 patients over two years. (
  • Mcr-1 provides relatively low resistance, and mcr-1 strains can still be treated with colistin, but at far higher doses, which is obviously detrimental to the patients as colistin is fairly toxic. (
  • However, they said that if doctors were to use them to treat psychiatric patients in the future, then it would be important to keep doses of the drugs low, and ensure they were given over a relatively short time period in combination with therapy sessions. (
  • Doses of the most effective drug to boost blood pressure in patients at risk of dying from infection-related shock were low at Johns Hopkins Hospital . (
  • The J&J drug also led to statistically significant reductions in systolic blood pressure at both doses (-2.6 mmHg and -4.4 mmHg), as well as reductions in diastolic blood pressure, or both ends of the blood pressure reading. (
  • According to NPR , "Gerard Sanacora, a professor of psychiatry at Yale University, has treated hundreds of severely depressed patients with low doses of ketamine . (
  • Berrey was referring to testing at the Viral Special Pathogens Branch of the federal Centers for Disease Control and Prevention and the NIH that showed brincidofovir had, in test tubes, showed 'activity' against the Ebola virus that was comparable to how the drug performed against other viral diseases, including smallpox and adenovirus. (
  • The patient traveled in April from India to the United States, through Chicago, the Centers for Disease Control and Prevention said Monday. (
  • The controversy centers on so-called specialty drugs, a somewhat imprecise term that generally encompasses products that can cost tens or even hundreds of thousands of dollars a year. (
  • In addition, 10 privately run nursing homes and rehabilitation centers also have treated patients with C. auris. (
  • Overdose deaths from all opioids -- which are responsible for two-thirds of drug overdose deaths -- more than doubled from 2006 to 2016, according to the U.S. Centers for Disease Control and Prevention. (
  • While nearly all surgeries provided medicines information to hospitals for non-emergency cases, a quarter were not systematically providing details on previous drug reactions, 14% on existing illnesses and 11% of known allergies, the report said. (
  • The report said primary care trusts, which are responsible for local health services, needed to do more to monitor and encourage hospitals and GPs to ensure drug information is shared properly. (
  • Lawson DM, Jick H (1976) Drug prescribing in hospitals: a international comparison. (
  • The drugs are among hundreds that have been in short supply at the nation's hospitals, and more recently, community pharmacies. (
  • Many drugs in short supply are given through injections or intravenously at hospitals, according to the FDA. (
  • Nearly 90 percent of the hospitals reported a drug shortage in the second half of 2010 that may have caused a patient safety issue, resulted in procedure's delay or cancellation, required expensive substitutes or resulted in a pharmacist compounding a drug. (
  • At hospitals across the country, 'scoring drugs' has taken on a new meaning. (
  • In many cases, hospitals have admitted to meeting drug needs by purchasing medicines on the "gray market," where prices are higher. (
  • If Hospitals Make Their Own Generics, Will Patients Benefit? (
  • A group of hospitals have joined together to make their own generic drugs in order to address rising prices and shortages. (
  • These issues do not just affect patients, but also hospitals trying to take care of them. (
  • Fed up by these problems, a group of hospitals and other organizations have joined together to form a nonprofit, generic drug company whose mission is to "ensure that essential generic drugs… are available and affordable to everyone. (
  • Right now, the effort is aimed at generic drugs used by hospitals for their patients, rather than drugs sold at pharmacies. (
  • But as Politico reports, this is only if hospitals pass the savings onto patients rather than just reducing their own bottom line. (
  • Drug shortages have become a huge problem in the United States, with hospitals struggling to find enough essential drugs like injectable morphine and sodium bicarbonate. (
  • Our first stop, however, was an Oct. 3 meeting with representatives from the Campaign for Sustainable Rx Pricing ( , a coalition of organizations representing physicians, employers, hospitals, nurses, patients, payers and pharmacists that seeks to address the causes of high drug prices through increased transparency and competition. (
  • Candida auris, also known as C. auris, is primarily found in hospitals and long-term health care sites, where it targets the most vulnerable patients with severe medical problems and compromised immune systems. (
  • Larger hospitals that provide more complex care are more likely to have patients with C. auris, because patients who are very sick are more likely to carry the fungus, he said. (
  • Hospitals can test for some drugs, like methamphetamine or cocaine, and those tests are pretty fast," Nicholas E. Manicke, Ph.D., says. (
  • Doctors for another Ebola patient, NBC News freelance cameraman Ashoka Mukpo, said they do not know if he will receive one of those drugs. (
  • It's good news, but it comes nearly two decades after the drug first went on the market and many patients have suffered that side effect. (
  • MONDAY, March 16, 2015 (HealthDay News) -- Patients with heart failure can sometimes also develop the dangerous irregular heartbeat known as atrial fibrillation , which can raise their odds for stroke . (
  • The drug in question, methylprednisone, is mostly used to treat older patients for lower back pain, according to an NBC News report . (
  • But a drug shortage that has worsened since 2009 is threatening that success rate, doctors report in Thursday's New England Journal of Medicine. (
  • It would require drug makers to notify the FDA of any event that could cause a shortage. (
  • Sen. Barbara Mikulski , a Maryland Democrat, signed on and said: 'The early warning system … makes sure providers and patients are the first to know when a drug shortage is about to occur. (
  • That advance notice will give them the time they need to adequately prepare and respond to a drug shortage. (
  • A nationwide drug shortage has left American hospital patients untreated and in pain. (
  • More than 100 drugs were put on the shortage list this year, prompting Congressional hearings and leading to an executive order by President Barack Obama, which forces drug companies to publicize their shortages.Health care workers have had no other option than to ration some medicines, giving it only to patients that need it most. (
  • Hurricane Sandy's aftermath has also increased the demand for certain drugs and contributed to the shortage. (
  • Update, the NYT has an editorial in their Sunday edition recommending the passage of two bills in congress requiring advanced notice from drug manufacturers in event of likely shortage. (
  • Three of every four drugs on the US government's shortage list were sterile injectable drugs, according to a report by HHS. (
  • At an online presentation for journalists in November, Valerie Jensen, associate director of the FDA's Drug Shortage Program, provided a casebook example. (
  • Many factors have been blamed for the shortage of generic drugs, including manufacturing and supply chain problems, as well as companies dropping drugs that don't make them enough money. (
  • Within weeks of the declaration of the Ebola epidemic, more than 250 possible drugs were proposed for clinical trials - far more than there were clinical trial sites available set up with the resources necessary to conduct the trials," he explained. (
  • The choices of drugs suitable for being prioritized in clinical trials were narrowed down by a WHO committee and were based on key criteria, including supportive preclinical evidence, which settled on drugs that had evidence of curing Ebola in nonhuman primates. (
  • The disclosure that Thomas Eric Duncan began receiving the drug brincidofovir came hours after its maker, Biopharma company Chimerix announced that the antiviral drug has been approved for emergency use in Ebola patients. (
  • Other Ebola patients soon could also be receiving the drug as a result of the Food and Drug Administration's decision to approve it on a compassionate-use basis. (
  • Brincidofovir joins two other experimental antiviral drugs that have already been deployed in the battle against Ebola. (
  • Tekmira Pharamceutical 's TKM-Ebola also has received clearance from the FDA for expanded access by doctors treating Ebola patients. (
  • Chimerix also said Monday it is 'working closely with the' FDA to finalize a protocol for a clinical trial early this week to assess the safety and efficacy of brincidofovir in patients confirmed to have Ebola. (
  • Chimerix also noted that clinical data collected during Phase 3 testing of brincidofovir for use in patients with cytomegalovirus and adenovirus infection have shown it be safe, which opened the door for an investigation into whether it is a potential therapy for Ebola. (
  • Also Monday, Leerink downgraded Tekmira Pharmaceuticals to 'market perform' from 'outperform' after re-evaluating the company's prospects with its Ebola drug following a more than 200-percent price rise in the stock price since July. (
  • The volunteer nurse from Eyke, Suffolk, was exposed to Ebola while working with patients in Sierra Leone. (
  • Desperate that his patients were dying from Ebola and running out of options, Dr. Gobee Logan from Liberia decided to try an HIV drug . (
  • He treated 15 Ebola patients with the drug, of which 13 survived. (
  • The idea to try the drug came from his reading of scientific studies and learning that HIV and Ebola have similarities in the way the replicate. (
  • Brown J, Dollery C, Valdes G (1986) Interaction of nonsteroidal anti-inflammatory drugs with anti-hypertensive and diuretic agents: control of vascular reactivity by endogenous prostanoids. (
  • Drugs like Copaxone that can modify the effects of the disease have been on a steep upward price trajectory in recent years, said Bari Talente, executive vice president for advocacy at the National Multiple Sclerosis Society. (
  • Patient advocates say that for some diseases, like multiple sclerosis, none of the drugs are inexpensive, making it impossible to avoid the high out-of-pocket costs unless people stop taking their medicine and endanger their health. (
  • Doctors are most excited about the possibility of combining ipilimumab with experimental targeted drugs called BRAF inhibitors that show promise in early studies , Hwu says. (
  • Nearly half of doctors also complained that it took too long for hospital discharge summaries to arrive, meaning patients were seen without a full set of records. (
  • Doctors sometimes substitute different drugs for ones in short supply. (
  • Doctors compared results among 181 Hodgkin lymphoma patients who received the drug to 40 others who were given a different chemotherapy, cyclophosphamide, when the first choice was unavailable. (
  • Investigation shows that more than 100,000 doctors, nurses, medical technicians and health care aides are abusing or dependent on drugs in a given year, and studies suggest the number could be far higher. (
  • A USA TODAY review shows more than 100,000 doctors, nurses, medical technicians and health care aides are abusing or dependent on prescription drugs in a given year, putting patients at risk. (
  • Pharmacists, doctors and advocacy groups say countless patients are getting less effective or more costly substitutes as a result. (
  • Once a drug reaches the market, aggressive promotion to doctors and advertising to consumers often lead to rapid growth in sales, so that, as in the case of Lotronex, hundreds of thousands of people are taking a new drug just months after its approval. (
  • At that price, insurance coverage is crucial, and patients and doctors fear that an FDA reversal will lead to most insurers no longer signing the checks. (
  • In terms of the lifestyles of patients with coronary disease, everything is moving in the wrong direction," said Dr. David Wood, one of the paper's authors and a professor of cardiovascular medicine at Imperial College in London. (
  • Leerink's downgrade was based on an analysis that Tekmira added $340 million in market valuation since the summer, which can only be justified if the company receives significantly more orders for stockpiling the drug than is likely at the moment. (
  • However, many people around the world who might benefit most from this therapy don't have access to it because the regulatory authorities haven't felt it safe for use in patients with advanced stages of liver disease due to hepatitis C. Our research shows the benefits of this drug include significantly improving the health of even the sickest patients, allowing them to return to their normal life sooner. (
  • But a major clinical trial has found that the risk of early menopause can be significantly reduced by adding a drug called goserelin to the chemotherapy regimen. (
  • For example, a serious, potentially life-threatening rash, Stevens-Johnson syndrome, that can be caused by carbamazepine therapy is significantly more common in patients who have the human leukocyte antigen allele HLA-B*1502 . (
  • The big catch: the current drugs already cost around $300,000 a year and adding a third drug would likely boost that cost significantly. (
  • Among them is ZMapp (Mapp Biopharmaceutical, Inc), a drug cocktail comprising three monoclonal antibodies made in plants, which is being studied in a clinical trial at sites in the United States and Sierra Leone. (
  • We believe the health changes associated with placebos should be better represented in the literature given to patients before they take part in a clinical trial. (
  • GW Pharmaceuticals plc announces positive preliminary results in a Phase II clinical trial in patients with pain caused by Rheumatoid Arthritis. (
  • He took part in the FOXTROT clinical trial, which used a drug called panitumumab. (
  • ZMapp was initially used in a few patients, but the supply of the drug produced by MAP Pharmaceuticals has run out. (
  • Pfizer initially said its donation of the drug Zithromax would end in 2020, the target for the worldwide elimination of the disease. (
  • Initially, patients who develop SAH, which is normally caused by a weakness in the wall of a blood vessel that bursts open, undergo a surgical procedure to repair the bleed. (
  • But with this drug some patients (20% of CML) did not respond to the drug or initially responded but later became resistant to the drug. (
  • The bug initially seems to have entered the patient population from the environment, but we think it has recently evolved to become capable of jumping from patient to patient, getting more virulent as it does so. (
  • Manicke says that initially, the device could be used to guide public health and public policy decisions, by shedding light on the types of drugs that are causing overdoses across Indiana. (
  • Initially, the drug will have to share the market with ipilimumab though longer term the drugs may be used in combination," Koch said. (
  • Miles Briggs, the Scottish Conservatives' public health spokesman said: "When the SNP set out on modifying the drugs approval system, it said it would reduce the chances of things like this happening. (
  • Anas Sarwar, Scottish Labour's health spokesman 'These cases are becoming more frequent and it is clear the system isn't working for patients. (
  • In a statement, the maker of Phenergan called the decision "disappointing, not only for Wyeth, for patients and public health in general. (
  • The report separates the country into 306 regional health care markets and examines variations among them in the quantity and quality of prescription drug use, spending, and use of brand name drugs. (
  • Health authorities are working to identify people who may have been exposed to a patient with a drug-resistant form of tuberculosis. (
  • She has an extensively drug-resistant form of tuberculosis, or XDR-TB, which is a relatively rare form of the disease that is resistant to at least four of the core anti-TB drugs, according to the World Health Organization . (
  • Dr. Michael E. Mullins of the Oregon Health Sciences University reported that four patients there went into shock within 12 hours after physicians switched them from Posicor to other calcium-channel blockers, such as felodipine and timolol. (
  • Given the dearth of new antibiotics in the pipeline, our best hope to avert the current public health crisis is to improve stewardship of existing drugs, by harnessing the potential of bacterial genome sequencing and translate it into improved surveillance and diagnostics tools," he added. (
  • America's prescription drug epidemic reaches deep into the health care community. (
  • A single addicted health care worker who resorts to "drug diversion," the official term for stealing drugs, can endanger thousands. (
  • oversight mechanisms to detect, report and address drug problems in health care settings are haphazard and limited. (
  • Still, a USA TODAY review of state and federal records identified hundreds of cases in recent years in which physicians and other health care practitioners were disciplined or prosecuted for drug diversion or other medical misconduct related to substance abuse. (
  • A nurse takes a blood sample for an HIV/AIDS test from patient Luis Antonio Marropquin, 53, at a health unit in San Salvador, Wednesday , June 27 , 2007. (
  • The drug company maintains it has been 'actively working' with health officials and that the risk from affected batches is actually low. (
  • However, placebos themselves have been shown to create substantial health changes in patients. (
  • She continues, "There is an important issue of consent here - patients should be fully aware of possible health changes from all treatments in a trial before agreeing to take part. (
  • Paul Davis, the chief of a rural ambulance squad in Ohio, told the New York Times that he was unable to give morphine to a woman with a broken leg because he was saving his last pills for patients he thought needed it more.Elsewhere, desperate health care workers are treating patients with expired drugs and less effective medicine. (
  • To combat the problem, the FDA has relaxed its restrictions on importing drugs and made it easier for manufacturers to get approval to make certain medicines.But this, too, has brought further problems to health care providers. (
  • In the worst known case, Alabama's public health department this spring reported nine deaths and 10 patients harmed due to bacterial contamination of a hand-mixed batch of liquid nutrition given via feeding tubes because the sterile pre-mixed liquid wasn't available. (
  • When serious side effects occur, especially with drugs being used on such an enormous scale, consumer advocates like Dr. Sidney Wolfe, who directs the Public Citizen Health Research Group in Washington, say that the only way to prevent further harm to patients is to get the drug off the market as quickly as possible. (
  • Patients who sign up for the 12-week support program linked to Lipitor receive a cookbook and weekly emails containing health advice. (
  • Health affairs discusses the increasingly frequent shortages of critical, life-saving, generic drugs. (
  • The bills aim to counter efforts by health plans to reduce the amount they pay for expensive medicines by making the patients pay a percentage, typically 20 to 35 percent, of the cost. (
  • Such drugs account for only 1 percent of total drug use, but 17 percent of drug spending by private insurers, according to IMS Health. (
  • In 2010, spending on specialty drugs jumped 17.4 percent, compared with only 1.1 percent for other drugs, according to Medco Health Solutions , a pharmacy benefits manager that merged this month with Express Scripts . (
  • Protecting the health and safety of Medicare patients is one of our primary concerns," Derrick L. Jackson of the HHS said in a statement. (
  • However, over 60 percent of patients consult a health care professional when selecting an OTC product,' she said. (
  • Improving compliance with prescribed regimens offers health care organizations--specifically, pharmaceutical companies, payers, providers and pharmacies--a significant opportunity to improve both the physical health of their patients and the financial health of their own institutions," says Boston Consulting Group Vice President Mark Lubkeman, one of the authors of the report. (
  • Seventeen health care facilities on Long Island have treated people with Candida auris, a deadly, drug-resistant fungus, according to state health officials. (
  • Seven of the Long Island facilities that have treated patients with C. auris infections are North Shore University Hospital, Glen Cove Hospital, Huntington Hospital and Southside Hospital, all operated by Northwell Health, as well as Mount Sinai South Nassau Hospital, NYU Winthrop Hospital and Stony Brook University Hospital. (
  • Drach, a biochemist and virologist who is a professor in the schools of dentistry and pharmacy, and Townsend, emeritus professor in chemistry and Pharmacy's medicinal chemistry, began researching cytomegalovirus in the 1980s, prompted by a National Institutes of Health call for proposals to find drugs to treat CMV infections. (
  • Founded in 1966, and with more than 14,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients. (
  • It modified the Controlled Substances Act, which requires the Drug Enforcement Administration (DEA) to identify "imminent danger to the public health and safety" before suspending the registration of a manufacturer, distributor, or dispenser for controlled substances privileges. (
  • Since it is toxic, the challenge is to figure out which patients will benefit most, Hwu says. (
  • But after carefully considering all the evidence, including the proposed 'patient access scheme' in which the manufacturer offered to provide every fourth pack free, sorafenib does not provide enough benefit to patients to justify its high cost. (
  • The new report offers an in-depth look at how prescription drugs are used by Medicare beneficiaries in the program's Part D drug benefit, which had 37 million enrollees in 2012. (
  • The 2006 introduction of the Medicare prescription drug benefit was a boon for beneficiaries, but the coverage had weak spots. (
  • We found the sicker a patient was, the more benefit they experienced by using sofosbuvir,' said Dr. Charlton. (
  • A Pfizer spokeswoman said the programs were designed to benefit patients rather than achieve commercial objectives. (
  • On the other hand, "there are those patients who are more likely to have rapidly growing disease, and therefore would more likely benefit from immediate systemic therapy," Cho added. (
  • Pharmaceutical companies would also benefit from such legislation because high co-payments discourage patients from taking their medicines. (
  • A steady supply of generic drugs should benefit all hospital patients who need them. (
  • We will need confirmation in future studies, but there may be more benefit from an FGFR-targeted therapy in patients with an FGFR alteration as compared to immunotherapy," Siefker-Radtke says. (
  • Tests found it could reduce the need for patients to undergo a mastectomy. (
  • The experts found that more young patients are smoking, and more patients are fatter and diabetic compared with similar groups from 12 years ago. (
  • Just as important, they found Tham boosted bacterial killing in the airways of pigs with CF and in sputum samples from human patients. (
  • Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. (
  • However, the drug has found another use outside of anesthesia and dangerous recreational use. (
  • OPTIMIZED OMEGA-3 A drug called Vascepa that contains a highly purified form of an omega-3 fatty acid found in fish oil reduced the risk of heart attack and stroke for some statin-taking patients. (
  • A shorter regimen for preventing tuberculosis has been found safe when co-administered with a new first-line HIV drug. (
  • Investigators for the Food and Drug Administration (FDA) found contamination in a sealed vial of the steroid at the company, the Post said. (
  • Farxiga is among AstaZeneca's five best-selling drugs and brought in revenues of $1.54 billion in 2019 for treating diabetes. (
  • People with high blood pressure who stop taking the anti-hypertension drug Posicor, which was withdrawn from the market June 8 by its manufacturer, risk going into shock if they begin taking certain other blood pressure drugs immediately, physicians warned Thursday. (
  • The optimal percutaneous coronary intervention (PCI) strategy and dual antiplatelet therapy (DAPT) duration in fragile patients remain unanswered. (
  • We assembled a prospective cohort of all patients undergoing percutaneous coronary intervention with either bare-metal or drug-eluting stents between Apr. (
  • The regions that excelled in beta blocker use did not necessarily achieve similar results with statin therapy, despite the fact that both beta blocker therapy and strict control of cholesterol levels are recommended by the National Committee for Quality Assurance (NCQA) for the same condition in the same patients. (
  • These results represent tremendous hope for these patients and their families. (
  • Detailed results of the studies appear in July 16 issue of The Lancet, although both trials have been discussed previously at medical meetings, and they formed the basis for the FDA approval of the drug in May. (
  • These single agent results "are comparable to those seen with more intensive chemotherapeutic regimens in this aged cohort of AML patients but with relatively low toxicity," they wrote online in the Proceedings of the National Academy of Sciences . (
  • The results were assessed using a timed test in which patients were asked to walk 25 feet as quickly and safely as possible. (
  • For the best results in these patients, kidney removal may be necessary. (
  • However, this trial was one of only two trials sponsored by the NCI to focus exclusively on patients living with HIV, and it has been the first prospective trial to report its results. (
  • Gleevec was a Swiss product and in 2001after approved by the Food and Drug Administration, made to the markets as the drug which attacks the BCR-ABL protein which results in the abnormal rise of leukocytes. (
  • The results presented at the Conference on Retroviruses and Opportunistic Infections, put to rest fears of potential drug interactions with DTG and pave way for scale-up of the 3HP regimen in high-burden TB countries. (
  • Psychedelics can give patients a new perspective -- particularly when things like suppressed memories come up -- and then they can work with that experience," Franz Vollenweider of the Neuropsychopharmacology and brain imaging unit at Zurich's University Hospital of Psychiatry, told Reuters. (
  • Some people believe that large kidney tumors actually suppress the immune system and are not very responsive to immunotherapy drugs, Cho said. (
  • When a new class of cholesterol drugs called PCSK9 inhibitors was introduced three years ago, it was heralded as a potential breakthrough, particularly for people at high risk of heart attack or stroke. (
  • There is also a looming practical issue - PCSK9 inhibitors cost nearly $14,000 a year, and insurers have largely balked at paying, unless a patient is deemed to be high risk and still has elevated LDL cholesterol while on the highest tolerated conventional lipid-lowering therapy. (
  • Farxiga, like other drugs in the so-called class of SGLT2 inhibitors, helps type-2 diabetics by prompting the kidneys to expel excess blood glucose through the urine. (
  • Astra is ahead of other makers of SGLT2 inhibitors - Eli Lilly and partner Boehringer Ingelheim with their drug Jardiance, and Johnson & Johnson with Invokana - in widening the drugs' use beyond diabetes. (
  • The NCI has generally allowed patients with HIV to enroll on the immuno-oncology studies that it sponsors with PD-1 and PD-L1 inhibitors. (
  • For a time this year, a psychiatric hospital run by the state of Maryland didn't have enough injectable drugs for schizophrenia patients who refused to take pills. (
  • Maintaining sterility during the manufacturing of injectable drugs can be particularly difficult, industry officials said. (
  • With such consolidation as well as tight inventory management practices, the specialized manufacturers of injectable drugs lack the flexibility to adapt to manufacturing disruptions. (
  • Because of this, the pancreas fails soon after birth, patients cannot properly digest food, and their airways fill with mucus, leaving them vulnerable to lung infections and other problems. (
  • The mcr-1 gene makes bacteria resistant to colistin, which is one of the very few drugs effective against multi-drug resistant infections. (
  • With the recent increase in antibiotic resistance, it has now become widely prescribed in the clinic as a last-line drug for infections such as E. coli and Klebsiella pneumoniae . (
  • Drugs for chemotherapy, infections, pain management and extreme high blood pressure are among those in short supply. (
  • The most common side effect was genital infections, which Matthews said occurred in about 10 percent of women and six percent of men taking the drug. (
  • CDC officials said based on a limited number of patients, 30% to 60% of people with C. auris infections have died, but they point out many of those patients were also seriously ill and had a higher risk of death. (
  • Most commonly, patients suffer from frequent lung infections and a buildup of mucus that makes it hard to breathe. (
  • The average Medicare Part D patient filled 49 standardized 30-day prescriptions in 2010. (
  • With the cost of specialty drugs increasing, some Medicare beneficiaries could owe thousands of dollars in out-of-pocket drug costs every year for a single drug. (
  • In a standard Medicare drug plan, beneficiaries pay 25 percent of the price of their brand-name drugs until they reach $5,100 in out-of-pocket costs. (
  • Delegates also referred to the Board a resolution advocating for prescription drug cost-saving measures for Medicare. (
  • According to a recent Kaiser Family Foundation poll ( , nearly 90 percent of Americans think drug companies should be more transparent about how they set prices, more than 80 percent think the federal government should be allowed to negotiate with manufacturers for better drug prices for Medicare beneficiaries, and nearly 80 percent think prescription drug prices are unreasonable. (
  • Had the court agreed that the FDA's approval shields the drug makers from lawsuits, the ruling likely would have ended tens of thousands of pending legal claims, industry experts said. (
  • The FDA and provider trade groups also say industry consolidation is a factor, as are makers who discontinue less profitable generic drugs or whose plants fail safety inspections. (
  • The makers of the drug, Eli Lilly, said it will appeal against the decision. (
  • Civica Rx will either directly manufacture the generic drugs or subcontract with other generic drug makers. (
  • Also, last year, 45 states and the U.S. Justice Department accused generic drug makers of price fixing, saying it has cost U.S. businesses and consumers more than $1 billion . (
  • Takeda Pharmaceuticals, which sells febuxostat under the brand name Uloric, paid for the test, which was mandated by the U.S. Food and Drug Administration when the drug was approved in 2009. (
  • Last year, the U.S. Food and Drug Administration extended that approval to include younger, premenopausal women. (
  • Three years ago, the Bush administration switched long-standing Food and Drug Administration policy and announced that federal approval of a drug "preempts" or bars suits in state courts. (
  • Besides evolocumab, the U.S. Food and Drug Administration in 2015 also approved another PCSK9 inhibitor, alirocumab (Praluent). (
  • Lotronex was taken off the market on Nov. 28, less than 10 months after being approved by the Food and Drug Administration. (
  • In March, the U.S. Food and Drug Administration put Jardiance up for a speedy review but it has yet to receive approval. (
  • This prompted the Food and Drug Administration to set up a task force in July to address the issue. (
  • New drugs go through three phases of clinical trials before the Food and Drug Administration decides on their approval. (
  • Based on the 2013 ACC/AHA guidelines for the management of patients with ST-elevation acute coronary syndromes (STE-ACS), an ACE inhibitor should be initiated within the first 24 hours to all patients with STE-ACS with anterior location, HF, or left ventricular ejection fraction (LVEF) ≤40% unless contraindicated. (