Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
Biocompatible materials placed into (endosseous) or onto (subperiosteal) the jawbone to support a crown, bridge, or artificial tooth, or to stabilize a diseased tooth.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
Implants used to reconstruct and/or cosmetically enhance the female breast. They have an outer shell or envelope of silicone elastomer and are filled with either saline or silicone gel. The outer shell may be either smooth or textured.
Artificial substitutes for body parts and materials inserted into organisms during experimental studies.
Insertion of an implant into the bone of the mandible or maxilla. The implant has an exposed head which protrudes through the mucosa and is a prosthodontic abutment.
Rounded objects made of coral, teflon, or alloplastic polymer and covered with sclera, and which are implanted in the orbit following enucleation. An artificial eye (EYE, ARTIFICIAL) is usually attached to the anterior of the orbital implant for cosmetic purposes.
Devices, usually alloplastic, surgically inserted into or onto the jawbone, which support a single prosthetic tooth and serve either as abutments or as cosmetic replacements for missing teeth.
A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)
A prosthesis that gains its support, stability, and retention from a substructure that is implanted under the soft tissues of the basal seat of the device and is in contact with bone. (From Boucher's Clinical Dental Terminology, 4th ed)
Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.
Surgical insertion of an electronic hearing device (COCHLEAR IMPLANTS) with electrodes to the COCHLEAR NERVE in the inner ear to create sound sensation in patients with residual nerve fibers.
The plan and delineation of dental prostheses in general or a specific dental prosthesis. It does not include DENTURE DESIGN. The framework usually consists of metal.
Endosseous dental implantation where implants are fitted with an abutment or where an implant with a transmucosal coronal portion is used immediately (within 1 week) after the initial extraction. Conventionally, the implantation is performed in two stages with more than two months in between the stages.
A general term for the complete loss of the ability to hear from both ears.
Natural teeth or teeth roots used as anchorage for a fixed or removable denture or other prosthesis (such as an implant) serving the same purpose.
The plan and delineation of prostheses in general or a specific prosthesis.
Removable prosthesis constructed over natural teeth or implanted studs.
Surgical insertion of a prosthesis.
Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.
Holding a DENTAL PROSTHESIS in place by its design, or by the use of additional devices or adhesives.
Devices implanted to control intraocular pressure by allowing aqueous fluid to drain from the anterior chamber. (Hoffman, Pocket Glossary of Ophthalmologic Terminology, 1989)
A ready-made or custom-made prosthesis of glass or plastic shaped and colored to resemble the anterior portion of a normal eye and used for cosmetic reasons. It is attached to the anterior portion of an orbital implant (ORBITAL IMPLANTS) which is placed in the socket of an enucleated or eviscerated eye. (From Dorland, 28th ed)
Chronic inflammation and granuloma formation around irritating foreign bodies.
Synthetic organosiloxane gels that are formed from synthetic polymers of silicone oxide with organic sidechains (polydimethylsiloxane) by lengthening the polymer chains. Unlike silicone elastomers, they are not treated with amorphous silica. They are used as fillers in breast implants.
An anabolic steroid used mainly as an anabolic agent in veterinary practice.
Absence of teeth from a portion of the mandible and/or maxilla.
A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
The process whereby an utterance is decoded into a representation in terms of linguistic units (sequences of phonetic segments which combine to form lexical and grammatical morphemes).
Inability or inadequacy of a dental restoration or prosthesis to perform as expected.
The shrinkage of the foreign body encapsulation scar tissue that forms around artificial implants imbedded in body tissues.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
An inflammatory process with loss of supporting bone in the tissues surrounding functioning DENTAL IMPLANTS.
Procedures for correcting HEARING DISORDERS.
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
Replacement for a hip joint.
The plan and delineation of DENTAL IMPLANT fitting with DENTAL ABUTMENT.
Preprosthetic surgery involving rib, cartilage, or iliac crest bone grafts, usually autologous, or synthetic implants for rebuilding the alveolar ridge.
Characteristics or attributes of the outer boundaries of objects, including molecules.
Surgical insertion of an inert sac filled with silicone or other material to augment the female form cosmetically.
Prostheses used to partially or totally replace a human or animal joint. (from UMDNS, 1999)
A mixture of metallic elements or compounds with other metallic or metalloid elements in varying proportions.
Partial hearing loss in both ears.
A non-steroidal estrogen analog.
The surgical removal of the inner contents of the eye, leaving the sclera intact. It should be differentiated from ORBIT EVISCERATION which removes the entire contents of the orbit, including eyeball, blood vessels, muscles, fat, nerve supply, and periosteum.
The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.
Tantalum. A rare metallic element, atomic number 73, atomic weight 180.948, symbol Ta. It is a noncorrosive and malleable metal that has been used for plates or disks to replace cranial defects, for wire sutures, and for making prosthetic devices. (Dorland, 28th ed)
Persons with any degree of loss of hearing that has an impact on their activities of daily living or that requires special assistance or intervention.
Replacement for a knee joint.
A partial denture attached to prepared natural teeth, roots, or implants by cementation.
Removal of an implanted therapeutic or prosthetic device.
Specialized devices used in ORTHOPEDIC SURGERY to repair bone fractures.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Replacement of the hip joint.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Multi-channel hearing devices typically used for patients who have tumors on the COCHLEAR NERVE and are unable to benefit from COCHLEAR IMPLANTS after tumor surgery that severs the cochlear nerve. The device electrically stimulates the nerves of cochlea nucleus in the BRAIN STEM rather than the inner ear as in cochlear implants.
Devices, usually incorporating unidirectional valves, which are surgically inserted in the sclera to maintain normal intraocular pressure.
A complete denture replacing all the natural mandibular teeth and associated structures. It is completely supported by the oral tissue and underlying mandibular bone.
Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.
Infections resulting from the implantation of prosthetic devices. The infections may be acquired from intraoperative contamination (early) or hematogenously acquired from other sites (late).
Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
Partial or total replacement of a joint.
The surgical removal of the eyeball leaving the eye muscles and remaining orbital contents intact.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.
Attachment of orthodontic devices and materials to the MOUTH area for support and to provide a counterforce to orthodontic forces.
The grafting of bone from a donor site to a recipient site.
The joining of objects by means of a cement (e.g., in fracture fixation, such as in hip arthroplasty for joining of the acetabular component to the femoral component). In dentistry, it is used for the process of attaching parts of a tooth or restorative material to a natural tooth or for the attaching of orthodontic bands to teeth by means of an adhesive.
A vinyl polymer made from ethylene. It can be branched or linear. Branched or low-density polyethylene is tough and pliable but not to the same degree as linear polyethylene. Linear or high-density polyethylene has a greater hardness and tensile strength. Polyethylene is used in a variety of products, including implants and prostheses.
Devices which are used in the treatment of orthopedic injuries and diseases.
A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
The air space located in the body of the MAXILLARY BONE near each cheek. Each maxillary sinus communicates with the middle passage (meatus) of the NASAL CAVITY on the same side.
Internal devices used in osteosynthesis to hold the position of the fracture in proper alignment. By applying the principles of biomedical engineering, the surgeon uses metal plates, nails, rods, etc., for the correction of skeletal defects.
The audibility limit of discriminating sound intensity and pitch.
One of a pair of irregularly shaped bones that form the upper jaw. A maxillary bone provides tooth sockets for the superior teeth, forms part of the ORBIT, and contains the MAXILLARY SINUS.
A computer based method of simulating or analyzing the behavior of structures or components.
Tests of the ability to hear and understand speech as determined by scoring the number of words in a word list repeated correctly.
Ability to make speech sounds that are recognizable.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body.
Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading.
Elements of limited time intervals, contributing to particular results or situations.
Specific alloys not less than 85% chromium and nickel or cobalt, with traces of either nickel or cobalt, molybdenum, and other substances. They are used in partial dentures, orthopedic implants, etc.
A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Synthetic thermoplastics that are tough, flexible, inert, and resistant to chemicals and electrical current. They are often used as biocompatible materials for prostheses and implants.
A prosthetic restoration that reproduces the entire surface anatomy of the visible natural crown of a tooth. It may be partial (covering three or more surfaces of a tooth) or complete (covering all surfaces). It is made of gold or other metal, porcelain, or resin.
Materials used in the production of dental bases, restorations, impressions, prostheses, etc.
Surgery necessary for a denture to rest on a firm base, free from marked osseous protuberances or undercuts, and devoid of interfering muscle attachments, excess mucoperiosteum, hyperplasias, and fibrous or papillary growths.

Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets. (1/1204)

A long-acting thymidine pellet consisting of 190 mg of cholesterol and 60 mg of thymidine has been developed for the study of thymidine metabolism and reutilization in vivo. Implantation of such a pellet s.c. in adult mice will maintain the blood plasma concentration of thymidine at levels between 40 and 8 X 10(-6) M, which are from 36 to 7 times those of normal mice, for periods up to 48 hr. During this period, in vivo uptake and reutilization of [125I]iododeoxyuridine, a thymidine analog, into intestinal and tumor DNA were almost completely suppressed. While iododeoxyuridine reutilization is not large in normal proliferative tissue even in the absence of pellet implants, reutilization of over 30% was measured in large, rapidly growing ascites tumors. The inhibition of iododeoxyuridine incorporation by elevated thymidine blood levels is directly proportional to serum concentration. This appears to be due to a thymidine pool in rapid equilibrium with blood thymidine. This pool is at least 10 times larger than the 4-nmole pool of extracellular thymidine.  (+info)

The effects of levonorgestrel implants on vascular endothelial growth factor expression in the endometrium. (2/1204)

Vascular endothelial growth factor (VEGF) expression and the microvascular density of the endometrium were studied in Norplant users and normal controls, using immunohistochemistry on formalin-fixed paraffin-embedded endometrial sections. The VEGF staining index was quantified using computerized image analysis. The VEGF staining index between stages of the menstrual cycle and between normal and Norplant endometria were compared. Norplant VEGF staining index was analysed for correlation with microvascular density, duration of Norplant use, the number of bleeding/spotting days in the reference period up to 90 days prior to biopsy, and the length of time since the last bleeding/spotting episode. The results showed that immunoreactive VEGF was detected predominantly in endometrial glands but weakly expressed in the stroma throughout the menstrual cycle, and also in Norplant users. Large variation in the VEGF staining index between individuals was observed and no significant difference in the VEGF staining index was detected between stages of the menstrual cycle for the glands and stroma. The glandular and stromal VEGF staining indices were significantly higher in Norplant than in normal endometrium (P<1x10(-4)). No correlation was found between the Norplant VEGF staining index and endometrial microvascular density, duration of Norplant use, the number of bleeding/spotting days in the reference period, and the length of time since the last bleeding/spotting episode. The VEGF staining index was higher in glands than stroma for both normal and Norplant endometrium. The results suggest a differential control of endometrial glandular versus stromal VEGF expression, and possible positive effects of levonorgestrel on VEGF expression.  (+info)

Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly. (3/1204)

Proper dorsal-ventral patterning in the developing central nervous system requires signals from both the dorsal and ventral portions of the neural tube. Data from multiple studies have demonstrated that bone morphogenetic proteins (BMPs) and Sonic hedgehog protein are secreted factors that regulate dorsal and ventral specification, respectively, within the caudal neural tube. In the developing rostral central nervous system Sonic hedgehog protein also participates in ventral regionalization; however, the roles of BMPs in the developing brain are less clear. We hypothesized that BMPs also play a role in dorsal specification of the vertebrate forebrain. To test our hypothesis we implanted beads soaked in recombinant BMP5 or BMP4 into the neural tube of the chicken forebrain. Experimental embryos showed a loss of the basal telencephalon that resulted in holoprosencephaly (a single cerebral hemisphere), cyclopia (a single midline eye), and loss of ventral midline structures. In situ hybridization using a panel of probes to genes expressed in the dorsal and ventral forebrain revealed the loss of ventral markers with the maintenance of dorsal markers. Furthermore, we found that the loss of the basal telencephalon was the result of excessive cell death and not a change in cell fates. These data provide evidence that BMP signaling participates in dorsal-ventral patterning of the developing brain in vivo, and disturbances in dorsal-ventral signaling result in specific malformations of the forebrain.  (+info)

Cephalosporin and aminoglycoside concentrations in peritoneal capsular fluid in rabbits. (4/1204)

To study the penetration of antibiotics into peritoneal tissue fluid, a subcutaneous tissue capsule model was modified by implanting multiple, perforated spherical capsules in the peritoneal cavity of rabbits. Capsules became vascularized, encased in connective tissue, and filled with fluid having a mean protein concentration of 3.6 g/100 ml. Capsular fluid was obtained by percutaneous needle aspiration and assayed for antibiotic by the disk plate bioassay technique. Cephalosporins were administered intramuscularly at a dose of 30 mg/kg. Mean peak concentrations of cephaloridine and cefazolin were significantly higher than cephalothin and cephapirin in capsular fluids, but the percent penetration (ratio of capsular mean peak to serum mean peak) ranged from 8.7 to 16.9% and was not significantly different among the cephalosporins. At 24 h the capsular concentration of cefazolin was significantly greater than for the other cephalosporins (P < 0.001). Lower rabbit serum protein binding observed at high in vivo concentrations may have enabled cefazolin to penetrate capsular fluid, but in vitro protein binding studies did not confirm a decrease in serum protein binding at high concentrations within the clinical range. Kanamycin and amikacin showed comparable capsular fluid peak concentrations as did gentamicin and tobramycin. The percent penetration ranged from 15.2 to 34.5% for the aminoglycosides. The only statistical difference was that amikacin penetration was significantly higher than that for tobramycin. Mean capsular concentrations of amikacin, cefazolin, and cephaloridine compared most favorably with the minimum inhibitory concentration of gram-negative bacilli at the dosages used in this study.  (+info)

Synchronization of estrus in beef cattle with norgestomet and estradiol valerate. (5/1204)

Fifty-six cows received a norgestomet implant and an injection of norgestomet and estradiol valerate; half (n = 28) received 500 IU equine chorionic gonadotrophin (eCG) at implant removal, 9 d later. A third group (n = 25) received 2 doses of cloprostenol (500 micrograms) 11 d apart. Estrous rate was higher (P < 0.05) for cows given norgestomet and estradiol plus 500 IU eCG (75.0%) than for those receiving cloprostenol (44.0%); for those receiving norgestomet and estradiol alone, it was intermediate (67.8%). Pregnancy rates to artificial insemination (after estrus or timed) were higher (P < 0.05) for cows given norgestomet and estradiol than for those given cloprostenol (23 of 28, 82.1% vs 13 of 25, 52.0%), and intermediate (67.8%) for those given norgestomet and estradiol plus eCG. In a second experiment, for heifers treated with norgestomet and estradiol plus eCG (n = 15) or with 2 doses of cloprostenol (n = 16), estrous rates were 66.7% vs 56.2% (P > 0.5), ovulation rates were 100.0% vs 81.2% (P = 0.08), intervals from implant removal or cloprostenol treatment to estrus were 48.0 +/- 4.4 hours vs 61.3 +/- 7.0 hours (P = 0.12) and to ovulation were 70.4 +/- 4.4 hours vs 93.2 +/- 7.5 hours (P < 0.01), respectively; pregnancy rates were 41.7 and 35.7%, respectively (P > 0.5). Norgestomet and estradiol were as good as (heifers) or superior to (cows) a 2-dose cloprostenol regimen. In cows given norgestomet and estradiol, injecting eCG at implant removal did not significantly improve estrous or pregnancy rates.  (+info)

Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study Group. (6/1204)

BACKGROUND: The intraocular ganciclovir implant is effective for local treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome (AIDS), but it does not treat or prevent other systemic manifestations of cytomegalovirus infection. METHODS: Three hundred seventy-seven patients with AIDS and unilateral cytomegalovirus retinitis were randomly assigned to one of three treatments: a ganciclovir implant plus oral ganciclovir (4.5 g daily), a ganciclovir implant plus oral placebo, or intravenous ganciclovir alone. The primary outcome measure was the development of new cytomegalovirus disease, either contralateral retinitis or biopsy-proved extraocular disease. RESULTS: The incidence of new cytomegalovirus disease at six months was 44.3 percent in the group assigned to the ganciclovir implant plus placebo, as compared with 24.3 percent in the group assigned to the ganciclovir implant plus oral ganciclovir (P=0.002) and 19.6 percent in the group assigned to intravenous ganciclovir alone (P<0.001). As compared with placebo, oral ganciclovir reduced the overall risk of new cytomegalovirus disease by 37.6 percent over the one-year period of the study (P=0.02). However, in the subgroup of 103 patients who took protease inhibitors, the rates of new cytomegalovirus disease were low and of similar magnitude, regardless of treatment assignment. Progression of retinitis in the eye that initially received an implant was delayed by the addition of oral ganciclovir, as compared with placebo (P=0.03). Treatment with oral or intravenous ganciclovir reduced the risk of Kaposi's sarcoma by 75 percent (P=0.008) and 93 percent (P<0.001), respectively, as compared with placebo. CONCLUSIONS: In patients with AIDS and cytomegalovirus retinitis, oral ganciclovir in conjunction with a ganciclovir implant reduces the incidence of new cytomegalovirus disease and delays progression of the retinitis. Treatment with oral or intravenous ganciclovir also reduces the risk of Kaposi's sarcoma.  (+info)

17 beta-estradiol reduces glycoxidative damage in the artery wall. (7/1204)

Glycoxidative damage in the vasculature has been linked to atherosclerotic cardiovascular disease. Estrogens protect against the development and progression of atherosclerosis. Because estrogens are potent antioxidants that also effect glucose metabolism, part of their protection against atherosclerosis could be through attenuation of glycoxidative damage in the vascular wall. In this study, we tested the hypothesis that chronic estradiol administration is associated with decreased levels of glycoxidative damage in arterial walls. We harvested and examined iliac arteries from ovariectomized, 8-month-old rats that had been implanted for 6 months with 1 of the following subcutaneous hormone pellets: low estradiol (2.5 mg estradiol), high estradiol (25 mg estradiol), P4 (200 mg progesterone), low estradiol and P4, placebo (no hormone), or control (no implant). Using pentosidine as a biomarker of glycoxidative damage, we found that all vessels from rats receiving estradiol (low estradiol, high estradiol, and low estradiol+P4) exhibited a 50% reduction in glycoxidative damage compared with P4, placebo, and control vessels (P<0.05). Consistent with this finding, we observed that estradiol-treated rats had a 30% decrease in tissue levels of hydroperoxides, a marker of oxidative stress. Finally, estradiol-treated rats had a small, but significant, decrease in plasma glucose levels (P<0.01). In summary, we report the novel finding that chronic estrogen administration is associated with significant decreases in glycoxidative damage and oxidative stress in the arterial wall. It seems likely that these actions may constitute a mechanism by which estrogen attenuates the progression of atherosclerosis.  (+info)

Millimeter-scale positioning of a nerve-growth-factor source and biological activity in the brain. (8/1204)

Toxicity prevents the systemic administration of many therapeutic proteins, and attempts at protein targeting via the circulatory system (i.e., "magic bullets") have failed in all but a few special cases. Direct administration at the target site is a logical alternative, particularly in the central nervous system, but the limits of direct administration have not been defined clearly. Nerve growth factor (NGF) enhances survival of cholinergic neurons and, therefore, has generated considerable interest for the treatment of Alzheimer's disease. We tested the effectiveness of local delivery by implanting small polymer pellets that slowly released NGF into the central nervous system of adult rats at controlled distances from a target site containing transplanted fetal cholinergic cells. NGF-releasing implants placed within 1-2 mm of the treatment site enhanced the biological function of cellular targets, whereas identical implants placed approximately 3 mm from the target site of treatment produced no beneficial effect. Effective NGF therapy required millimeter-scale positioning of the NGF source, and efficacy correlated with the spatial distribution of NGF concentration in the tissue; this result suggests that NGF must be delivered within several millimeters of the target to be effective in treating Alzheimer's disease. Because the human brain is divided into functional regions that are typically several centimeters in diameter and often irregular in shape, new methods for sculpting larger-scale drug fields are needed. We illustrate a concept, called pharmacotectonics, in which drug-delivery systems are arranged spatially in tissues to shape concentration fields for potent agents.  (+info)

Purpose: To evaluate the anatomical and functional efficacy of a single injection of dexamethasone intravitreal implant 0.7mg (Ozurdex, Allergan) for diabetic macular edema (DME).. Methods: We administered a single dose of dexamethasone intravitreal implant in 18 eyes of 18 consecutive patients with type 2 diabetes and cystoid macular edema. Of these 18 eyes, 10 eyes (Group 1) had DME refractory to previous intravitreal anti-VEGF treatment (plus focal laser in 3 eyes), and 8 eyes received dexamethasone implant as a first line therapy (Group 2). Follow up was scheduled 1 week after injection and than monthly for four months. We measured variations in foveal thickness (FT) and macular volume (MV) at SD-OCT, changes in ETDRS visual acuity, intraocular pressure and lens opacity (LOCS chart III) in phakic eyes. Patients were further divided in two sub-groups based on glycated haemoglobin (HbA1c) ± 8.5%.. Results: Changes in FT and MV between preop and follow up visits were statistically similar in ...
Ozurdex (dexamethasone) is used to certain eye conditions. Learn side effects, dosage, drug interactions, warnings, patient labeling, reviews, and more.
Purpose : Elevated intraocular pressure (IOP) is a well-known possible adverse event associated with steroid treatments, such as dexamethasone intravitreal implant (DEX-I). We performed a prospective study to evaluate the safety of DEX-I (0.7 mg, Ozurdex®, Allergan) in the treatment for persistant diabetic macular edema (DME). Methods : We included a total of 32 eyes of 24 patients with persistant DME. Inclusion criteria: patients ≥18 years, with diagnosis of type 2 diabetes, DME resistant to previous treatments, BCVA (ETDRS) in the study eye between 34 and 79 letters, CRT (SD-OCT) ≥300 mm. Data were pooled for analysis in order to obtain median values and standard deviations. Exclusion criteria: uncontrolled diabetes (HbA1c ,10%), blood pressure ,160/100 mmHg, treatment with intravitreal anti-VEGF within 3 months of study entry, treatment with intravitreal triamcinolone within 6 months of study entry, current use or anticipated use of systemic steroids during the study, uncontrolled ...
Evidence-based recommendations on dexamethasone intravitreal implant (Ozurdex) for treating macular oedema secondary to retinal vein occlusion
TY - JOUR. T1 - Multicenter study of intravitreal dexamethasone implant in non-infectious Uveitis. T2 - Indications, outcomes and reinjection frequency. AU - Zarranz-Ventura, Javier. AU - Carreño, Ester. AU - Johnston, Robert L. AU - Mohammed, Quresh. AU - Ross, Adam H. AU - Barker, Carl. AU - Fonollosa, Alex. AU - Artaraz, Joseba. AU - Pelegrin, Laura. AU - Adan, Alfredo. AU - Lee, Richard W. AU - Dick, Andrew D. AU - Sallam, Ahmed. N1 - Copyright © 2014 Elsevier Inc. All rights reserved.. PY - 2014/9/8. Y1 - 2014/9/8. N2 - PURPOSE: To identify clinical outcomes and treatment patterns of intravitreal dexamethasone implant (Ozurdex®) in non-infectious uveitis in the clinical setting.DESIGN: Multicenter retrospective cohort study.METHODS: 82 eyes (63 patients) receiving 142 implant injections over 35 months were included. Treatment indication, uveitis diagnosis, visual acuity, intraocular pressure, vitreous haze score, central retinal thickness by optical coherence tomography, phakic status, ...
A 62 year old man with cystoid macular edema secondary to a branch retinal vein occlusion received an uneventful dexamethasone intravitreal implant 3 months earlier. The macular edema of the patient had reduced following the implant. However, because there was a recurrence of edema within 3 months, reinjection of a dexamethasone intravitreal implant was planned. The injection procedure of the second implant was performed in the same manner and approximately at the same site (4 mm inferotemporal to limbus) as the first implant. While performing the procedure with the aid of a microscope, the surgeon noticed a small, thinner implant floating posterior to the new one in the vitreous cavity (Figure 3). This seemed to be a result of dislodgement of the partially biodegraded matrix of the first implant, which had become relatively fixed in the peripheral vitreous base near the injection site; the pressure from the new implant was posited as the cause of its dislodgement. The concern of the operating ...
Morphological and functional changes in recalcitrant diabetic macular oedema after intravitreal dexamethasone implant. Dan Calugaru, Mihai Calugaru Department of Ophthalmology, Univ of Medicine Cluj-Napoca/Romania Re: Morphological and functional changes in recalcitrant diabetic macular oedema after intravitreal dexamethasone implant. Iacono et al. Br J Ophthalmol 2016;http:/ Dear Editor We would like to address several challenges that have arisen from the study by Iacono et al (1), which can be specifically summarized below. 1. The study was uncontrolled and was carried out on a small study population. There was a selection bias attributable to the heterogeneous prior treatments administered to the patients, namely, panretinal photocoagulation (PRP), grid photocoagulation, focal laser photocoagulation, and anti-vascular endothelial growth factor (VEGF) injections. Nothing was stated regarding the existence of a washout period between previous PRP, ...
Macular oedema is an accumulation of fluid within the central part of the retina (the macula). This can lead to loss of the normal architecture and function of the macula causing distortion and deterioration of central vision. Macular oedema results from a breakdown in the blood-retinal barrier, with fluid accumulating both interstitially and within the retinal glial cells (Müller cells). It can occur in patients with diabetic retinopathy, retinal vein occlusions or ocular inflammation (uveitis). Macular oedema is diagnosed clinically and monitored with optical coherence tomography (Box 1, Figure 1 and Figure 2).. ...
What is this medicine? DEXAMETHASONE (dex a METH a sone) is a corticosteroid. It is placed in the eye during a procedure and is used to help treat swelling in
Visit your doctor or health care professional for regular checks on your progress. You will need to have regular eye exams after your procedure.. Make sure to follow all of the instructions given to you by your health care provider after your procedure. Because you may have blurred vision or a temporary change in vision after the procedure, follow all directions regarding driving or operating machinery.. ...
A study of eyes with persistent diabetic macular edema after multiple anti-vascular endothelial growth factor injections indicates that a dexamethasone implant combined with bevacizumab improves visual acuity and macular morphology significantly.
Smith, R. P., Khanna, A., Coward, R. M., Rajanahally, S., Kovac, J. R., Gonzales, M. A. and Lipshultz, L. I. (2013), Factors Influencing Patient Decisions to Initiate and Discontinue Subcutaneous Testosterone Pellets (Testopel) for Treatment of Hypogonadism. Journal of Sexual Medicine, 10: 2326-2333. doi: 10.1111/jsm.12226 ...
PDF Similar Articles Mail to Author Mail to Editor Dexamethasone Intravitreal Implant in Patients with Macular Edema Due to Retinal Vein Occlusion: 6 months results Alper ŞENGÜL1, Özgür ARTUNAY2, Esra TÜRKSEVEN KUMRAL3, Melda YENEREL4, Rıfat RASİER1, Emine SAVRAN ELİBOL5, Nejla TÜKENMEZ DİKMEN5, Şahin SEVİM4 Turkish Abstract Abstract ...
PDF Similar Articles Mail to Author Mail to Editor Dexamethasone Intravitreal Implant in Patients with Macular Edema Due to Retinal Vein Occlusion: 6 months results Alper ŞENGÜL1, Özgür ARTUNAY2, Esra TÜRKSEVEN KUMRAL3, Melda YENEREL4, Rıfat RASİER1, Emine SAVRAN ELİBOL5, Nejla TÜKENMEZ DİKMEN5, Şahin SEVİM4 Turkish Abstract Abstract ...
PDF Similar Articles Mail to Author Mail to Editor Dexamethasone Intravitreal Implant in Patients with Macular Edema Due to Retinal Vein Occlusion: 6 months results Alper ŞENGÜL1, Özgür ARTUNAY2, Esra TÜRKSEVEN KUMRAL3, Melda YENEREL4, Rıfat RASİER1, Emine SAVRAN ELİBOL5, Nejla TÜKENMEZ DİKMEN5, Şahin SEVİM4 Turkish Abstract Abstract ...
In this article Dr Anat Lowenstein explains that the benefits of treatment with a dexamethasone intravitreal implant for DME were observed across a variety of demographic characteristics.
Dexamethasone (dex-a-METH-a-sone) Treats macular edema, uveitis, and diabetic macular edema. This medicine is a corticosteroid. Brand Name(s): Ozurdex
Results There was no statistically significant difference of mean change of the logarithm of the minimum angle of resolution BCVA between IVB and IVD groups at monthly visits, up to 12 months (all p,0.05); however, there was a trend towards greater BCVA gain in the IVB group than in the IVD group at 6 months (p=0.053). Additionally, 52.6% in the IVB group and 50% in the IVD group gained two or more lines of Snellen visual acuity at 12 months (p=0.85). The mean CFT decreased by 160 µm for the IVB group and by 140.7 µm for the IVD group at 12 months. Both the IVB group and the IVD group achieved statistically similar improvement of CFT at monthly visits, up to 5 months (all p,0.05); however, the CFT began to deteriorate after 5 months in the IVD group, and at 6 months, improvement in the IVB group was significantly greater than that in the IVD group (p=0.007). After a second IVD injection at 6 months, the IVD group showed significant improvement of CFT, and there was no significant difference of ...
An effective sustained release method of drug administration, using methylprednisolone incorporated into acrylic bone cement, has been developed. The effect of this form of treatment on peripheral...
Dexamethasone implants (Ozurdex®) should be considered as an effective alternative for the treatment of postoperative macular oedema (Irvin-Gass Syndrome), especially in refractory cases with severe reduction in visual acuity and very high values of central retinal thickness (CRT). Close observation of these patients is required to reduce the risk of vision loss and prevent permanent damage of visual function due to changes in the multi-layer structure of neuro-sensory retina NRR and retinal pigment epithelium RPE caused by a large postoperative macular oedema.. Back to previous ...
A system and device for maintaining and/or creating patency in airways is disclosed. The methods of using the system and device are also disclosed. The system includes a power source that energizes a electro-active polymer implant. The energized polymer implant provides stiffness and shape to the airway, thereby minimizing collapse or deformation of the airway. A method of making the device is also disclosed.
A novel biodegradable polymeric implant material (Polyepsiloncaprolacton-Butylacrylat, PCL-BA) was used for the reconstruction of a complete defect of the gastric wall in Sprague-Dawley-Rats (n = 42). ). In the control group the defect of the gastric wall was closed by primary wound closure (n = 21). In the baseline group (n = 21) the animals were kept under same conditions without any surgical procedure. This group was used for reference values. In another implantation group the gastric wall defect was closed by using Poly-L-Lactid (PLL). These experiments had to interrupt after 15 animals (n = 15) because of serious complications like perforation of the gastric wall, fistula and peritonitis. The implantation time was 7 days, 4 weeks and 6 months in all animals. In the PCL-BA and in the control group as well as in the baseline group no complications were detected. After explantation different parameters of the immune respone (C5b, C3b, CD2, CD14, CD68 and IgG) have been detected by ...
It sounds counterintuitive, and possibly illogical: a drug implant to combat the addiction of drugs? But, the U.S. Food and Drug Administration (FDA) recen | Clinical And Molecular Dx
Addbio has developed a solution to solve the real problem in the implant industry - weak bone. By coating any implant on the market with its proprietary bioactive nanolayer with a bone-strengthening drug, the bone grows stronger which stabilises the implant, thereby reducing the risk of complication...
To test the efficacy of a 0.7 mg intravitreal dexamethasone implant (Ozurdex®) on macular function and recalcitrant macular edema associated with retinal vein
RETISERT (fluocinolone acetonide intravitreal implant) 0.59 mg is used to treat an inflammation in the back of the eye that is not caused by an infection, called chronic non-infectious uveitis
Evidence-based recommendations on fluocinolone acetonide intravitreal implant (Iluvien) for chronic diabetic macular oedema after prior therapy
Uncommon Macular Holes and How to Treat Them -Jerzy Nawrocki, MD, PhD Alls Well That Ends Well: A Case of Impacted Intraocular Foreign Body (IOFB) With Retinal Detachment - Srinivas Joshi, MD Slurry Kenalog®: How to Concentrate Triamcinolone Acetonide for Intraocular Injection: A Lower Cost, Quick and Easy Alternative for Long-Term Intraocular Steroid Delivery - Susan M. Malinowski, MD Surgeons Point-of-View Intraoperative Video Recording in Ocular Oncology - Dilraj S. Grewal, MD. Do It Yourself Pick-Your Way Out in Difficult Situations - Hemanth Murthy, MBBS, MD. Extreme Retina - I Still Belief in 99% Perspiration & 1% Inspiration - Subhendu Kumar Boral, MBBS, MD(AIIMS), DNB(OPHTHALMOLOGY) Frag Bag: A Novel Technique For Removal of Retained Lens Material - Sharon Fekrat, MD, FACS Vitreoretinal Surgery in Retinal Capillary Hemangiomas - Mudit Tyagi, MS. A Novel Way to Inject Dexamethasone Intravitreal Implant (Ozurdex) - Michael A. Singer, MD. Star Wars. Episode IV: The IOFB Strikes Back ...
Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results. Haller JA, Bandello F, Belfort R Jr, Blumenkranz MS, Gillies M, Heier J, Loewenstein A, Yoon YH, Jiao J, Li XY, Whitcup SM; Ozurdex GENEVA Study Group, Li J.. ...
Aim To investigate late changes in peripheral ischemia in patients affected by diabetic macular edema (DME) and treated with repeated dexamethasone (DEX) intravitreal implants over a 1-year period.
In final draft guidance, the National Institute for Health and Clinical Excellence (NICE) here has recommended an intravitreal implant that delivers 0.7 mg of dexamethasone via an applicator (Ozurdex, Allergan) for the treatment of macular edema (ME) due to central retinal vein occlusion and also for branch retinal vein occlusionin cases in which laser photocoagulation is neither beneficial nor appropriate.
Objective was to evaluate the efficacy and safety of the histrelin acetate subdermal implant (originally versus Lupron Depot-3 Month) in male patients with advanced prostate cancer during 52 weeks of treatment with the implant. After consultation w/ FDA, design was modified to eliminate the Lupron arm and continued the study as an open-label non-randomized study.. Primary endpoint was testosterone suppression, as assessed by the percent of patients whose testosterone indicated chemical castration levels (,=50 ng/dL) through 52 weeks of treatment with an implant. ...
It is concerning that the recent research on naltrexone implants in Australia has not followed usual scientific processes. In particular, naltrexone implants have not been subject to the usual rigorous scrutiny required for new drug products seeking registration in this country. Nevertheless, they are available through the TGA Special Access Scheme; there is no requirement for TGA approval for access to unapproved goods in Australia for Category A patients under this Scheme, and no apparent requirement for collection of efficacy or safety data. Supporters of the naltrexone implant have argued that heroin injectors meet the criteria for Category A patients under the Scheme as persons who are seriously ill with a condition from which death is reasonably likely to occur within a matter of months, or from which premature death is reasonably likely to occur in the absence of early treatment ...
A group of 97 spring-calving beef cows were initially oestrus synchronised with controlled internal drug release (CIDR) intravaginal progesterone implants inserted for nine days and a prostaglandin injection on day 7. Approximately half the cows were given 10 μg buserelin when the implants were inserted, and they all received a single fixed-time artificial insemination (Al) 56 hours after the withdrawal of the implants. The overall pregnancy rate to the first synchronised Al was 55 per cent, the buserelin-treated cows having a pregnancy rate of 63 per cent compared with 47 per cent in the untreated cows (P,0.05). Sixteen days after the first synchronised Al all the cows were re-implanted with used CIDR implants which were removed five days later, and the cows received a second synchronised Al on days 23 to 24. Cows which received the second Al were implanted with new CIDR devices 16 days later and these were removed after five days and the non-pregnant cows received a third synchronised Al. The ...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
Long-term Stability of Soft Tissue Esthetic Outcomes Following Conventional Single Implant Treatment in the Anterior Maxilla: 10-12 Year Results
Alany Raid (2010) Transdermal delivery of bioidentical progesterone with a steroid. Progesterone Implant Menopause what can cause bloating and weight gain? can last how during long Enlarged Blood Uterus Vessels glycosylation in the endocervical mucus during the menstrual cycle. These results were robust to changes in the baseline assumptions of the model. A lower dose may be necessary in the elderly and in children and patients with Side Effects: Hypersensitivity reactions thrombocytopenia (usually reversible. some oviparous) reptiles in places from which the eggs have been shed at ovulation.. Rogers I Han R Savouret JF Casper RF: Resveratrol a natural aryl. enzyme immunoassay kit USA and Canada) respectively. I go to the gym but nothings help this thal body. or most commonly seen class effect toxicities are noted. It has been claimed that the menopausal syndrome is related more to personal It has been shown dosage premenopause andropause causes that symptom prevalence does not necessarily ...
come from London being using heroin for 10 … 12 years … I wanted to try some Naltrexone implants cause I want to take away the option of preemptive to get drugs and use them. So I check the internet and found doctor Aleksej here in Belgrade … and I turned up this morning and its all done. Its very easy and everything is cool here and it didnt hurt. So you get my recommendation.. In our hospital for naltrexone implant we had patients from all over the world: London, Dublin, Belfast, Manchester, Coventry, Nottingham, Sunderland, Brighton, Salford, Oxford, Canterbury, St Albans, Preston, Lancaster, Norwich, Cambridge, Glasgow, Edinburgh, Aberdeen, Cardiff, Dublin, UK, England, Scotland, Ireland, Wales, Europe, Norway, Italy, Switzerland, United states, Australia, Canada.... ...
This study was conducted to assess the impact of implanting intact beef males with protein anabolic agents at varying intervals throughout life. Ninety-six intact males were assigned to three implant treatments: 1) not implanted, 2) implanted at 9 wk of age, weaning and at 56-d intervals thereafter with a 36-mg zeranol implant or 3) estradiol implant at 9 wk of age and 68 d post-weaning. During the 118-d, post-weaning growing period, eight animals per treatment (one replication) were castrated. After a 114-d finishing period, cattle were slaughtered (average age of 13 to 14 mo). Feedlot performance, carcass and palatability data were obtained. Average daily gains and feed efficiency did not differ (P|.05) between zeranol and estradiol-implanted intact males. Regardless of implant treatment, steers had lighter carcass weights (P|.05) and higher (P|.01) quality grades than intact males. Implanting either intact males or steers with zeranol or estradiol resulted in higher (P|.05) numerical yield grades.
Macular Disease Foundation Australia welcomes the news that Ozurdex® (dexamethasone implant) will be listed on the Pharmaceutical Benefits Scheme (PBS) from 1 November 2016. The PBS listing allows Ozurdex to be used in people with diabetic macular oedema who have already had cataract surgery or are scheduled to have cataract surgery, and:
Of 138 patients who received an implant, one discontinued prior to Day 28 when the implant was expelled on Day 15. Three others did not have an efficacy measurement for the Day 28 visit. Otherwise serum testosterone was suppressed to below the castrate level (≤ 50 ng/dL) in all 134 evaluable patients (100%) on Day 28. All three patients with missing values at Day 28 were castrate by the time of their next visit (Day 56).. Once serum testosterone concentrations at or below castrate level (≤ 50 ng/dL) were achieved, a total of 4 patients (3%) demonstrated breakthrough during the study. In one patient, a serum testosterone of 63 ng/dL was reported at Week 44. In another patient, a serum testosterone of 3340 ng/dL was reported at Week 40. This aberrant value was possibly related to lab error. In two patients, serum testosterone rose above castrate level and the implant could neither be palpated nor visualized with ultrasound. In the first patient, serum testosterone was 669 ng/dL at Week 8 and ...
Visit your doctor or health care professional for regular checks on your progress. You will need to have regular eye exams after your procedure.. Make sure to follow all of the instructions given to you by your health care provider after your procedure. Because you may have blurred vision or a temporary change in vision after the procedure, follow all directions regarding driving or operating machinery.. ...
Naltrexone implant is an opiate blocker that is inserted beneath the skin of opiate users to reduce the chances of relapse once the person has detoxed.
Drug and Alcohol Findings Effectiveness Bank analysis titled: Naltrexone implant for the treatment of polydrug dependence: a randomized controlled trial
Great Prices For Bulk Orders. Savings On Brand & Generic Drugs. Naltrexone Implant Canada. Buy Lows Drugs Is A Licensed Canadian Online Pharmacy Providing Mail Order.
Joshi, L, Yaganti, S, Gemenetzi, M, Lightman, S, Lindfield, D, Liolios, V, Menezo, V, Shao, E and Taylor, SRJ (2013) Dexamethasone implants in retinal vein occlusion: 12-month clinical effectiveness using repeat injections as-needed ...
What is this medicine? GANCICLOVIR (gan SYE kloe veer) is an antiviral medicine. It is used to treat infections caused by certain kinds of viruses.
Connective tissue progenitors (CTP) can act as a pluripotent source of reparative cells during injury and therefore have great potential in regenerative medicine and tissue engineering. However, the response of CTP to most growth factors and cytokines is unknown. Many envisioned applications of CTP, such as treating large defects in bone, involve in vivo implantation of CTP attached to a scaffold, a process that creates an acute inflammatory environment that may be hostile to CTP survival. This project entails the design of a two-component polymeric implant system to aid in the healing process of bony defects by influencing cell behaviors at the implant site through the covalent modification of the implant surface with selected ligands. We investigate cellular responses of CTP on a biomaterial surface covalently modified with epidermal growth factor (EGF) and find that surface-tethered EGF (tEGF) promotes both cell spreading and survival more strongly than saturating concentrations of soluble ...
Histrelin has a molecular formula of C66H86N18O12, a.a. sequence of Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt and having a Mw of 1323.32 Dalton.
Scientists from the Oak Crest Institute of Science, in Pasadena, CA, report that they have developed a matchstick size implant, similar to a contraceptive implant, that successfully delivers a controlled, sustained release of ARV drugs for up to 40 days in dogs with no adverse side effects. To our knowledge this is the first implant to be used for this purpose, says Dr. Marc Baum, president and founder of Oak Crest. Daily administration of oral or topical ARV drugs to HIV negative individuals in vulnerable populations is a promising strategy for HIV prevention. However, adherence to the dosing regimen has emerged as a critical factor in determining effective outcomes in clinical trials. This novel device will revolutionize how we treat or prevent HIV/AIDS as it delivers powerful HIV-stopping drugs and eliminates one of the key obstacles in HIV/AIDS prevention -- adherence to proper dosing regimens, he adds. ...
Savvas, M., et al. Increase on bone mass after one year of percutaneous oestradiol and testosterone implants in post-menopausal women who have previously received long-term oral oestrogens. British Journal of Obstetrics and Gynaecology, Vol. 99. September 1992. Page 757-760 ...
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Detailed Histrelin dosage information for adults and children. Includes dosages for Prostate Cancer and Precocious Puberty; plus renal, liver and dialysis adjustments.
Find information on Histrelin (Supprelin LA, Vantas) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
Supprelin is a long-lasting histrelin implant used to block puberty in individuals with precocious puberty or who are transgender.
By Gene H. Deutscher, Extension Beef Specialist. This guide discusses the benefits and concerns in the use of growth implants with beef heifers.
Jamey Summers of Northampton is in a good mood for someone about to have surgery. He is sitting in an exam chair in Dr. Kate Atkinsons office in Amherst while the doctor and her staff go over the procedure. They will insert four small rods containing...
Ozurdex official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
Would these two componets work at all if made into transdermals with either T-Gel or transport matrix. I know they are best if injected but I was just
I have been up and down the last year, just cant get my numbers in range, or they get in range and then fall off. Then my E2 shoots up, and
"International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 8 December 2016.. ... Nexplanon, another subdermal contraceptive implant. References[edit]. *^ a b c d e f g Shoupe, Donna; Jr, Daniel R. Mishell ( ... Levonorgestrel-releasing implant is implanted under the skin in the upper arm of a woman, by creating a small incision and ... Jadelle and Sino-implant (II), and 1-rod implants, Implanon and Nexplanon/Implanon NXT-are easier to insert and remove.. ...
FDA Backgrounder on Platinum in Silicone Breast Implants. U.S. Food and Drug Administration. [2008-09-09]. (原始内容存档于2008-07-24). ... Wheate, NJ; Walker, S; Craig, GE; Oun, R. The status of platinum anticancer drugs in the clinic and in clinical trials. Dalton ... Platinum in silicone breast implants. Biomaterials. 2006, 27 (17): 3274-3286. PMID 16483647. doi:10.1016/j.biomaterials.2006.01 ...
Soundrapandian, C; Datta S; Sa B (2007). "Drug-eluting implants for osteomyelitis". Critical Reviews in Therapeutic Drug ... Risks for developing osteomyelitis include diabetes, intravenous drug use, prior removal of the spleen, and trauma to the area ... When adults are affected, it may be because of compromised host resistance due to debilitation, intravenous drug abuse, ... Local and sustained availability of drugs have proven to be more effective in achieving prophylactic and therapeutic outcomes. ...
FDA Executive Summary Memorandum - Metal-on-Metal Hip Implant System (PDF) (Report). Food and Drug Administration. 27 June 2012 ... "Metal-on-Metal Hip Implants". Food and Drug Administration. February 10, 2011. Retrieved January 4, 2012. "FDA seeks more ... "Concerns about Metal-on-Metal Hip Implants". Food and Drug Administration. 17 January 2013. Retrieved 15 March 2013. 2018 ... On February 10, 2011, the U.S. FDA issued a patient advisory on metal-metal hip implants, stating it was continuing to gather ...
PCL has been widely used in long-term implants and controlled drug release applications. However, when it comes to tissue ... A variety of drugs have been encapsulated within PCL beads for controlled release and targeted drug delivery. In dentistry (as ... PCL has been approved by the Food and Drug Administration (FDA) in specific applications used in the human body as (for example ... a drug delivery device, suture, or adhesion barrier. PCL is used in the rapidly growing field of human esthetics following the ...
It is having a rapid growth in the prosthesis, medical implants, novel drug formulations and the bioprinting of human tissues ... It can be used to produce specialized splints, prostheses, parts for medical devices and inert implants. The end goal of 3D ... Besides, 3D printing will be more useful in medical implants. An example includes a surgical team that has designed a tracheal ... For instance, AI is important in drug discovery because it can search relevant studies and analyze different kinds of data. In ...
Merck is developing a subdermal drug-eluting implant to administer islatravir. Islatravir has activity against HIV in animal ... "Someday, an Arm Implant May Prevent H.I.V. Infection for a Year". New York Times. July 23, 2019. "Merck Presents Early Evidence ... Islatravir (4′-ethynyl-2-fluoro-2′-deoxyadenosine, EFdA, or MK-8591) is an investigational drug for the treatment of HIV ... Roy M. Gulick (2018). "Investigational Antiretroviral Drugs: What is Coming Down the Pipeline". Top Antivir Med. 25 (4): 127- ...
"Tiny implant opens way to deliver drugs deep into the brain". AP NEWS. 2018-01-24. Retrieved 2020-02-10. "Women in Engineering ... Existing pharmacologic treatments, however, often rely on systemic drug administration, which result in broad drug distribution ... This technology could extend the battery life of implanted electronics or eliminate the need for battery replacement, sparing ... Given that many key neural circuitries have sub-cubic millimeter volumes and cell-specific characteristics, small-volume drug ...
Drug interactions: It is possible that the implant has similar drug interactions as combined oral contraceptives.[13] However, ... In some cases, a fibrous sheath may have formed around the implant, in which case the sheath must be incised.[13] The implant ... "International Drug Price Indicator Guide. Retrieved 8 December 2016.. *^ Winner, B; Peipert, JF; Zhao, Q; Buckel, C; Madden, T ... and the implant.[22] However, these concerns are less for the implant and POP and more for DMPA injection. ...
Treatment consists of Anti-VEGF drugs like Lucentis or intravitreal steroid implant (Ozurdex) and Pan-Retinal Laser ... A systematic review studied the effectiveness of the anti-VEGF drugs ranibizumab and pagatanib sodium for patients suffering ...
Nanoporous materials are emerging throughout the biomedical industry in drug delivery, implants, and tissue engineering. The ... especially regarding devices that are implanted in the body. A material interacts with the environment at its surface, so the ...
Pedersen, Amanda (22 August 2011). "NewCo on the block: Intersect ENT wins PMA for drug-releasing implant". Medical Device ... It manufactures drug-delivery devices used by Ear, Nose & Throat (ENT) clinicians in the treatment of sinusitis. Intersect ENT ... Its most known device is the Propel mometasone furoate implant that is used after sinus surgery to keep the sinus passageways ... Fink, Jennifer L. W. (December 2011). "Drug-Eluting Sinus Stent Hits the Market: May help maintain patency after FESS". ENT ...
More recently developed forms of drug delivery include suppositories, subdermal implants, skin patches and gels. They have more ... "Therapeutic Advances in Drug Safety. 6 (2): 45-56. doi:10.1177/2042098614568300. ISSN 2042-0986. PMC 4406918 . PMID 25922653.. ... Subcutaneous implant (surgically-inserted pellets placed into fat tissue). *Other less common routes like sublingual, buccal, ... Fraser IS, Mansour D (March 2006). "Delivery systems for hormone replacement therapy". Expert Opin Drug Deliv. 3 (2): 191-204. ...
Fair Price Shops aim to reduce the costs of medicines, drugs, implants, prosthetics, and orthopedic devices. Currently, there ... Furthermore, the drugs are unbranded and must be prescribed by their generic name. As there is less advertising required for ... This right was used in 2012, when Natco was allow to produce Nexavar, a cancer drug. In 2005, new legislation stipulated that a ... As doctors prescribe 60% generic drugs, the cost of treatment has been reduced by this program. This is a solution to ...
"Oregon DOJ case means doctors could tell patients ties to drug, implant makers". Retrieved 22 April 2016. " ... The following year, BIOTRONIK released Orsiro to the market-the world's first hybrid drug-eluting stent with a bio-absorbable ... Since its start, more than 19 million BIOTRONIK devices in over 100 countries have been implanted. In 1976, the company moved ... Meier, Barry (April 2, 2011). "Tipping the Odds for a Maker of Heart Implants". International New York Times. "Lake Oswego ...
They also created implants made of silk and drug compounds which can be implanted under the skin for steady and gradual time ... They are implanted during reconstructive surgery to support or restructure damaged ligaments, tendons, and other tissue. ... including pharmacological drugs, in the place of silk proteins. Bombyx mori females are also one of the few organisms with ...
However, Chávez discovers that the horses were surgically implanted with drugs, matching Kevin's story. Chávez now believes ... Kevin shows Chávez a herd of horses that he claims the Alcorta family use for drug smuggling. Gómez arrives on the scene and ...
The U.S. Food and Drug Administration has estimated that 416,000 AICDs were implanted between 1990 and 2002 in the United ... An implantable defibrillator is a device implanted under the skin through an incision in the shoulder. Leads from the implanted ... implanted the first AICD in a human patient in February 1980. At the time of the implantation, Mirowski and Mower had ... In fact, the implanted defibrillator system represents an imperfect solution in search of a plausible and practical application ...
"FDA Backgrounder on Platinum in Silicone Breast Implants". U.S. Food and Drug Administration. Archived from the original on 24 ... The Food and Drug Administration and other institutions have reviewed the issue and found no evidence to suggest toxicity in ... Platinum drugs are used to treat a wide variety of cancers, including testicular and ovarian carcinomas, melanoma, small-cell ... Apps, Michael G; Choi, Eugene H Y; Wheate, Nial J (August 2015). "The state-of-play and future of platinum drugs". Endocrine- ...
Additional work involved Dow Corning breast implants, the diet drug Fen-phen, Brown & Williamson tobacco and popcorn flavoring ...
Reclassification of Implanted Blood Access Devices". Food and Drug Administration. 25 July 2014. Dr Lowri Bowen (2019). "Huber- ... Intravenous drug use: If an intravenous drug user is discharged to be treated with a port in place to be treated on an ... The side of the patients' chest the port is implanted in will usually be chosen to avoid damage to the port and the veins by ... Under the skin, the port has a septum (a silicone membrane) through which drugs can be injected and blood samples can be drawn ...
This drug can be administered remotely through an implanted intravenous line or an intracerebroventricular injection. Self- ... especially reinstatement of drug-seeking after extinction. Drugs with this effect may be useful for treating people with drug ... exposure to a reinforcing drug after the extinction of drug-seeking operant behavior can often reinstate drug-seeking, and can ... In many cases, it appears that social stress can potentiate drug reinstatement just as strongly as exposure to the drug itself ...
The U.S. Food and Drug Administration gave U.S. approval for a collagen meniscus implant (CMI) device designed by Stone in 2008 ... the Collagen Meniscus Implant, the first successful and commercialized tissue-engineering template for re-growing the meniscus ... Juice products are available nationwide at major warehouse clubs, grocery stores and drug stores.[18][19] ... The process allows the tissues to be implanted in people leading to the first successful xenograft ligament for ACL ...
In the medical field, PBS could be used as biodegradable drug encapsulation systems, and is also investigated for implants. In ... as drug encapsulation systems". Colloids and Surfaces B:Biointerfaces. 84 (2): 498-507. doi:10.1016/j.colsurfb.2011.02.005. hdl ...
The game also manages numerous other mechanics about the player including drug addiction, mutations, broken limbs, and bionic ... implants. The world can be persistent between games. When starting a new character after the death of a previous character, the ...
Additionally, borosilicate tubing is used as the feedstock for the production of parenteral drug packaging, such as vials and ... cochlear implants, and physiological sensors. During the mid-20th century, borosilicate glass tubing was used to pipe coolants ... Applications include veterinary tracking devices, neurostimulators for the treatment of epilepsy, implantable drug pumps, ... thus making it well suited for injectable-drug applications. This type of glass is typically referred to as USP / EP JP Type I ...
"Intarcia raises $75M, touts final data as it preps to launch once-yearly diabetes drug implant". " ... the therapeutic consists of exenatide delivered via its Medici Drug Delivery System, "a drug delivery platform that stabilizes ... where it discovers and develops peptides for its drug delivery system. In 2005, the executive leadership of Intarcia was ...
Retrieved May 14, 2018.CS1 maint: multiple names: authors list (link) "Urogynecologic Surgical Mesh Implants". Food and Drug ... Boston Scientific is primarily known for the development of the Taxus Stent, a drug-eluting stent which is used to open clogged ... It was the second drug-eluting stent approved in the United States. In April 2004 the company announced that it had exercised ... Scott Pelley (May 13, 2018). "Gynecological mesh: The medical device that has 100,000 women suing, A common surgical implant ...
The M117D is released in a high-drag configuration for a ground implant or shallow water mining. It detonates when an object ... The M117 can be configured with a conical low-drag tail for medium and high altitude deliveries or a high-drag tail fin for low ... M117R The M117R (R - Retarded) uses a special fin assembly providing either high-drag or low-drag release options. For low ... MAU-91A/B High-drag tail assembly utilized to drastically reduce the free-fall speed of the M117 and when utilized in low-level ...
... s are used as hydrophobic implant materials for drug depots for continuous drug delivery by surface erosion. The ... Such drug implants are particularly suitable for applications on the eye, where no sudden release occurs by diffusion (initial ... Polyorthoesters type IV are considered the most promising members of this class as implant materials for controlled drug ... Biodegradable Polymers as Drug Delivery Systems, in Drugs and the Pharmaceutical Sciences, 45, Marcel Dekker, Inc., 1990, ISBN ...
The Medicaid Drug Rebate Program and the Health Insurance Premium Payment Program (HIPP) were created by the Omnibus Budget ... implants and grafts.[78] ... "Medicaid Drug Rebate Program Overview". HHS. Archived from the ... This program was formed due to the costs that Medicaid programs were paying for outpatient drugs at their discounted prices.[14 ... The most provided services are intermediate care for mentally handicapped, prescription drugs and nursing facility care for ...
Illegal - various gaseous, vaporised or aerosolized recreational drugs Medical use[edit]. Diagnostic[edit]. Various specialized ... Gases and other drugs used in anaesthesia include oxygen, nitrous oxide, helium, xenon, volatile anaesthetic agents. Medication ...
U.S. Food and Drug Administration. Retrieved 2010-10-15.. *^ "Title 21-Food and drugs: Chapter i-Food and drug administration: ... Of the more than 1,100 predicate implants that the new implants were substantially equivalent to, only 3% had any publicly ... U.S. Food and Drug Administration. Retrieved 2010-10-15.. *^ a b c d e f "General and Special Controls". Medical Devices. U.S. ... United States (Food and Drug Administration)Edit. Section 201(h) of the Federal Food Drug & Cosmetic (FD&C) Act[6] defines a ...
Further in the future, stem cell biotechnology may also make this possible, with no need for anti-rejection drugs. ... hair implants, and breast augmentation are also aesthetic components of their surgical treatment. ... may eventually make childbearing possible by using a donor uterus long enough to carry a child to term as anti-rejection drugs ...
" 3 January 2018. Retrieved 5 January 2018.. *^ O'Toole, S.; Mullan, F. (2018). "The role of the diet in tooth wear" ( ... and particularly is not recommended during pregnancy or when prescription drugs are used; comfrey is not recommended for oral ...
Biomaterials are also used every day in dental applications, surgery, and drug delivery. For example, a construct with ... or may be bioactive with a more interactive functionality such as hydroxylapatite coated hip implants. ... plastic which is used extensively as the glide rails for industrial equipment and the low-friction socket in implanted hip ... impregnated pharmaceutical products can be placed into the body, which permits the prolonged release of a drug over an extended ...
For years, the concept of harvesting stem cells and re-implanting them into one's own body to regenerate organs and tissues has ... This treatment has been approved by the Food and Drug Administration in 2016 for adult treatment only. Autologous matrix- ... The implanted chondrocytes then divide and integrate with surrounding tissue and potentially generate hyaline-like cartilage. ... The cells grow in self-organized spheroid matrices which are implanted via injected fluid or inserted tissue matrix. ...
2.0 2.1 U.S. Department of Health and Human Services.FDA approves implanted brain stimulator to control tremors. Retrieved ... DBS was approved in the United States by the Food and Drug Administration for the treatment of Parkinson's in 2002.[2] DBS ... Implant boosts activity in injured brain. Nature news (August 1, 2007). Retrieved on August 1, 2007 ... The Food and Drug Administration approved DBS as a treatment for tremors in 1997, for Parkinson's disease in 2002,[2] Tourette ...
This phalloplasty procedure involves the insertion of a subcutaneous soft silicone implant under the penile skin. [7][8][9][10] ... Three days prior to the procedure, a patient is placed on oral fluoroquinolone, an antibacterial drug. During this time, the ... Penile implants require a neophallus of appropriate length and volume in order to be a safe option. The long term success rates ... Muench, Peter J. (2013). "Infections Versus Penile Implants: The War on Bugs". Journal of Urology. 189 (5): 1631-1673. doi: ...
Men who wear clothing associated with femininity are often called cross-dressers.[126] A drag queen is a man who wears ... Cross-dressing and drag are two public performances of femininity by men that have been popularly known and understood ...
Mason, M; Welsh, EJ; Smith, I (May 31, 2013). "Drug therapy for obstructive sleep apnoea in adults". The Cochrane Database of ... Neurostimulation is currently being studied as a method of treatment;[63] an implanted hypoglossal nerve stimulation system ... Temporary spells of OSA syndrome may also occur in individuals who are under the influence of a drug (such as alcohol) that may ... This can be caused by drugs or alcohol, or it can be caused by neurological problems or other disorders. Some people have more ...
GnRH agonists are pregnancy category X drugs. Side effects[edit]. Side effects of the GnRH agonists are signs and symptoms of ... Implant; Injection. 2005a. 9,190 Buserelin. Suprefact. Breast cancer; Endometrial hyperplasia; Endometriosis; Female ... Nasal spray; Injection; Implant. 1984. 253,000 Deslorelin. Ovuplant; Suprelorin. Veterinary medicine (assisted reproduction; ... GnRH agonists can be administered by injection, by implant, or intranasally as a nasal spray. Injectables have been formulated ...
The first implant took place in March 1960, with two further implants the following month. These three patients made good ... The patient may be given a drug for relaxation before the surgery as well. An antibiotic is typically administered to prevent ... The other end of a pacemaker lead is actually implanted into the heart muscle. In addition leads that have been implanted for a ... The first use of transvenous pacing in conjunction with an implanted pacemaker was by Parsonnet in the United States,[44][45][ ...
Sometimes injections of hyaluronidase can be used to speed the dispersal of the fluid/drug. Infiltration is one of the most ... Removal of a port is usually a simple outpatient procedure; however, installation is more complex and a good implant is fairly ... Wanger and colleagues had in effect invented the modern I.V.-drip method of drug delivery [...]. ... The peripheral veins of intravenous drug addicts, and of cancer patients undergoing chemotherapy, become sclerotic and ...
Examples of radiosensitizing drugs include: Cisplatin, Nimorazole, and Cetuximab. The effect of radiotherapy on control of ... Another technique is the real-time tracking and localization of one or more small implantable electric devices implanted inside ... In 2002, the United States Food and Drug Administration (FDA) approved ibritumomab tiuxetan (Zevalin), which is an anti-CD20 ... A third technique is to enhance the radiosensitivity of the cancer by giving certain drugs during a course of radiation therapy ...
"US Food and Drug Administration. 15 May 2019. Retrieved 31 July 2019.. ... There are a number of methods of removing or occluding the fallopian tubes, some of which rely on medical implants and devices ... to the effectiveness of long-acting reversible contraceptives such as intrauterine devices and contraceptive implants, and ...
In addition to drugs being specific to a certain kind of organism (bacteria, fungi, etc.), some drugs are specific to a certain ... Some bacteria are able to form biofilms by adhering to surfaces on implanted devices such as catheters and prostheses and ... Additionally, strains of an organism may be resistant to a certain drug or class of drug, even when it is typically effective ... Whilst drug resistance typically involves microbes chemically inactivating an antimicrobial drug or a cell mechanically ...
Implantation of loop recorders (implanted ECG recorders for long-term monitoring of ECG to allow for diagnosis of an arrhythmia ... Therapeutic modalities employed in this field include antiarrhythmic drug therapy and surgical implantation of pacemakers and ... Electrophysiologists are often involved when severe or life-threatening arrhythmias are being treated, or when multiple drugs ... Initial administration and monitoring of the effect of drugs for treatment of heart rhythm disorders. ...
In 1935, certain strains of L. acidophilus were found very active when implanted in the human digestive tract.[58] Trials were ... In the United States, the Food and Drug Administration (FDA) and Federal Trade Commission (FTC) have issued warning letters and ... "Compliance Branch, Inspections, Compliance, Enforcement, and Criminal Investigations, US Food and Drug Administration. Archived ... "Compliance Branch, Inspections, Compliance, Enforcement, and Criminal Investigations, US Food and Drug Administration and ...
Because the drug was too expensive to obtain on his own, and because the pharmacist who discovered and sold the drug had no ... Institutional autonomy is having the capacities as a legislator to be able to implant and pursue official goals. Autonomous ... Brainwashing or drugging criminals into being law-abiding citizens would be immoral as it would not be respecting their ...
Jason travels the world to see how the belief in God may be implanted into our brains. ... Drugs, Inc. (since 2010). *Wicked Tuna (since 2012). *Life Below Zero (since 2013) ...
The last surgical procedure that can be done to help prevent the reoccurrence of seizures in the frontal lobes is to implant a ... Drugs such as Topiramate cause problems such as mental blunting, word retrieval difficulties and irritability. Phenobarbital, ... Hormonal changes and pregnancy can shift seizure activity and the use of antiepileptic drugs can alter the efficacy of hormones ... Medications such as anti-epileptic drugs can typically control the onset of seizures, however, if medications are ineffective ...
Oxygen in these higher percentages is classified as a drug with too much oxygen being potentially harmful to a patient's health ...
For the development of the modern cochlear implant - a device that bestows hearing to individuals with profound deafness.[18] ... For the discovery of artemisinin, a drug therapy for malaria that has saved millions of lives across the globe, especially in ... The discovery of the statins-drugs with remarkable LDL-cholesterol-lowering properties that have revolutionized the prevention ...
An implant is inserted, then the person wears a conformer shield and later the person will have their prosthesis made and ... Kim JW, Abramson DH, Dunkel IJ (2007). "Current management strategies for intraocular retinoblastoma". Drugs. 67 (15): 2173- ...
Nonproprietary drug name (USP format) Common chemical name Acronym Comments Technetium Tc 99m lidofenin hepatobiliary ... Journal of Long-Term Effects of Medical Implants. 15 (3): 329-338. doi:10.1615/JLongTermEffMedImplants.v15.i3.90. PMID 16022643 ...
"FDA approves new drug for advanced prostate cancer" (Press release). Food and Drug Administration. 15 May 2013. Archived from ... Brachytherapy with implanted seeds (for prostate cancer) was first described in 1983.[173] ... Seruga B, Ocana A, Tannock IF (January 2011). "Drug resistance in metastatic castration-resistant prostate cancer". Nature ... "U.S. Food and Drug Administration. 2011-04-28. Archived from the original on 2013-09-22.. ...
US Food and Drug Administration. Retrieved 2016-01-21.. *^ "Baclofen Overdose: Drug Experimentation in a Group of Adolescents ... a chronic intrathecal catheter is inserted from the spine through the abdomen and attached to the pump which is implanted under ... " Retrieved 3 March 2019.. *^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March ... Recent Patents on CNS Drug Discovery. 1 (1): 113-18. doi:10.2174/157488906775245291. PMID 18221197. Archived from the original ...
Drug Induced Hair Loss', American Hair Loss Association: "American Hair Loss Association - Drug Induced Hair Loss". Archived ... Hair transplants, takes tiny plugs of skin, each which contains a few hairs, and implants the plugs into bald sections. The ... "Drug-Induced Hair Loss". Archived from the original on 2013-08-24.. Cite uses deprecated parameter ,deadurl=. (help). ... "Drug-Induced Hair Loss". Archived from the original on 2013-07-26.. Cite uses deprecated parameter ,deadurl=. (help). ...
Goserelin Implant: learn about side effects, dosage, special precautions, and more on MedlinePlus ... An implant with 3.6 mg of goserelin is usually inserted every 4 weeks. An implant with 10.8 mg of goserelin is usually inserted ... Goserelin implant may harm the fetus.You should not plan to become pregnant while using goserelin implant or for 12 weeks after ... Goserelin implant may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *headache ...
Histrelin Implant: learn about side effects, dosage, special precautions, and more on MedlinePlus ... the current implant should be removed and can be replaced with another implant to continue treatment. Histrelin implant ( ... Histrelin implant (Vantas) is used to treat the symptoms associated with advanced prostate cancer. Histrelin implant (Supprelin ... If you miss an appointment to receive an implant of histrelin or to have histrelin implant removed, you should call your ...
Provided by Stedmans medical dictionary and Includes medical terms and definitions. ... Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ... provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and ... supraperiosteal implant. Definition: an alloplastic graft inserted superficial to the periosteum to change the contour of an ...
Experts in Australia say the use of naltrexone implants to treat drug dependency should be stopped because of a number of ... Posted in: Drug Trial News. Tags: Alcohol, Alcohol Dependence, Dehydration, Heroin, Hospital, Implants, Naltrexone, Research, ... Experts say naltrexone implants for drug dependency are risky. *Download PDF Copy ... Experts in Australia say the use of naltrexone implants to treat drug dependency should be stopped because of a number of ...
Researchers from Tufts University have demonstrated an electronic implant - composed of silk and magnesium - that eliminated ... In lab settings, devices were implanted in vivo (within the living) in S. aureus bacteria-infected tissue and activated by a ... These wireless strategies could help manage post-surgical infection or pave the way for eventual wi-fi drug delivery, he ... Devices completely dissolved after 15 days, and magnesium levels at the implant site and surrounding areas were comparable to ...
These implants undergo surface erosion, achieving tightly controlled and reproducible drug release kinetics in vitro. As an ... Here, the authors report on drug delivery implants formed solely from corticosteroid dimers, which demonstrate controlled ... based on a discovery that low molecular weight corticosteroid dimers can be processed into drug delivery implant materials ... dexamethasone dimer intravitreal implants demonstrate predictable pharmacokinetics and significantly extend drug release ...
The seton implant is positioned through the trabecular meshwork so that an inlet end of the seton implant is exposed to the ... which involve bypassing diseased trabecular meshwork with the use of a seton implant. The seton implant is used to prevent a ... The surgical method and novel implant are addressed to the trabecular meshwork, which is a major site of resistance to outflow ... Ocular implants deployed in schlemms canal of the eye. US9549846. Jul 27, 2015. Jan 24, 2017. Novartis Ag. Drug delivery ...
Easy-to-read patient leaflet for Carmustine Intracranial Implant. Includes indications, proper use, special instructions, ... Generic Name: Carmustine Intracranial Implant (kar MUS teen). Brand Name: Gliadel. Medically reviewed by Last ... You must check to make sure that it is safe for you to take carmustine intracranial implant with all of your drugs and health ... Keep all drugs out of the reach of children and pets. *Throw away unused or expired drugs. Do not flush down a toilet or pour ...
... implanted in a matchstick-sized rod under the skin, holds promise for shielding people from HIV. But it is years from market. ... Merck released research showing a potent new drug, ... The new drug, islatravir, and the implant were developed by the ... The new implant prototype provided a continuous drug dose high enough to shield against the virus for three months, Hanna said ... Another four test subjects received a placebo, in an early study designed to assess the safety of the drug and implant. They ...
The surgery involves implanting a device that acts as a kind of pacemaker for the brain. But some argue the human testing ... Experimental brain implants studied as drug addiction treatment. The surgery involves implanting a device that acts as a kind ... China has a long, if troubled, history of brain surgery for drug addiction. Even today, Chinas punitive anti-drug laws can ... Years of drug use cost him his wife, his money and his self-respect, before landing him in this drab yellow room at a Shanghai ...
Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Visit ... Reported Side Effects for Nexplanon Contraceptive Implant. Close Inability To Sleep Incidence: ,5.0%* Severity: MILD Onset: ... Visit the Drug Summary page where you can: *Get answers to Frequently Asked Questions (FAQs) ... This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience ...
Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Visit ... Visit the Drug Summary page where you can: *Get answers to Frequently Asked Questions (FAQs) ... Avoid - This drug is known to cause harm to infants when taken by nursing mothers. ... This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience ...
There have been a number of well-controlled studies on drug-eluting implants in the paranasal sinuses, specifically implants ... Sinus implants for chronic rhinosinusitis: technology evaluation. Expert Opin. Drug Deliv. (2013) 10(12).. Li PM, Downie D, ... ARS POSITION STATEMENT ON DRUG-ELUTING IMPLANTS. September 14, 2016. The American Rhinologic Society endorses the utilization ... Rizzo J, Rudmik L, Mallow P, Palli S. Budget impact analysis of bioabsorbable drug-eluting sinus implants following endoscopic ...
Upon implantation of the implant within a body, the therapeutic agent is released and the bioerodible metal portion erodes to ... A medical implant can include a bioerodible metal portion and a coating overlying the bioerodible metal portion. The coating ... Medical devices with drug-eluting coating. US8382824. 3 Oct 2008. 26 Feb 2013. Boston Scientific Scimed, Inc.. Medical implant ... A medical implant can replace, support, or act as a missing biological structure. Some examples of medical implants can include ...
Source Reference: Prieto-Alhambra D, et al "Bisphosphonate use and improved implant survival: a nationwide cohort study" BSR ... Among 80,000 patients ages 40 and up who had received joint implants between 1998 and 2007, 1,950 had used bisphosphonates for ... Because bisphosphonates seemed to help preserve implant survival through anti-osteoclast effects in an earlier U.K. cohort, his ... Be aware that the overall rate of implant failure was very low, limiting the power of subgroup analyses. ...
... are twice as likely to have dental implants fail as those who are not taking SSRIs. ... To read the full text "Selective Serotonin Reuptake Inhibitors and the Risk of Osseointegrated Implant Failure, A Cohort Study" ... "Even so, we were surprised to discover that the negative effect of SSRIs on dental implants was so strong, almost equal to that ... Follow-ups took place with the patients between three and 67 months after the implant was done to see whether it had been ...
University of British Columbia researchers have developed a magnetic drug implant -- the first of its kind in Canada -- that ... "Drug implants can be safe and effective for treating many conditions, and magnetically controlled implants are particularly ... The drug is injected into the device and then surgically implanted in the area being treated. Passing a magnet over the ... University of British Columbia researchers have developed a magnetic drug implant--the first of its kind in Canada--that could ...
Used to deliver drug directly into a brain tumor site and typically implanted post-surgically, the wafer is made of a ... Used to deliver drug directly into a brain tumor site and typically implanted post-surgically, the wafer is made of a ... The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or ... carmustine implant A synthetic, biodegradable wafer containing the agent carmustine with antineoplastic activity. ...
Used to deliver drug directly into a brain tumor site and typically implanted post-surgically, the wafer is made of a ... Used to deliver drug directly into a brain tumor site and typically implanted post-surgically, the wafer is made of a ... The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or ... polifeprosan 20 with carmustine implant. US brand name:. Gliadel. Gliadel wafer. Abbreviation:. Gliadel. ...
home drugs a-z list Implanon(Etonogestrel Implant) side effects drug center ... In some cases implants have been found within the vasculature including the pulmonary artery. Some cases of implants found ... Our Implanon Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects ... Related Drugs. Annovera Aurovela * Health Resources. Birth Control Options (Types and Side Effects) Pregnancy Test Birth ...
Can Implants Cause Breast Cancer?. Refinery 29 UK via Yahoo Sports· 2 years ago. On Wednesday, the Food and Drug Administration ... The risk of developing cancer from breast implants is high enough that the Food and Drug ... Breast implants linked to rare cancer recalled, US says. AFP via Yahoo News· 2 years ago. Breast implant maker Allergan has ... These Breast Implants Have Been Recalled Because of Their Link to a Rare Cancer. Self via Yahoo News· 2 years ago. "The U.S. ...
A removable balloon is as good as a permanent stent implant for opening small blocked arteries, according to late breaking ... Drug coated balloons are as good as stent implants for treating small blocked arteries. *Download PDF Copy ... BASKET-SMALL 2 is the largest randomized trial to examine whether drug coated balloons are as good as drug-eluting stents for ... Patients were randomized to receive drug coated balloon angioplasty (382 patients) or second-generation drug-eluting stent ...
... by Tristan Greene - in Science ... developed a novel system of drug delivery using deep-brain implant technology. This may solve the problems of unwanted ... Its not perfect though, theres a lot of work to be done before the implants are ready for prime-time. For one, just because ... One of the problems with central nervous system drugs is that theyre not specific, and if youre taking them orally they go ...
... wirelessly controlled implant that delivers individually sealed doses of medication has been tested in humans for the first ... The implant was used to deliver 20 individually sealed doses of an osteoporosis drug called teriparatide (parathyroid hormone). ... Scientists report proof-of-concept trial of wireless drug delivery implant. 16/02/2012 ... You can do remote control delivery, you can do pulsatile drug delivery, and you can deliver multiple drugs. ...
Drug delivery devices and methods. US8672870. 17 Jul 2008. 18 Mar 2014. Transcend Medical, Inc.. Ocular implant with hydrogel ... Ocular implant for controlling glaucoma. US5882327 *. 17 Abr 1997. 16 Mar 1999. Jacob; Jean T.. Long-term glaucoma drainage ... Ocular implant with stiffness qualities, methods of implantation and system. US8172899. 26 Sep 2011. 8 May 2012. Transcend ... Ocular implant with stiffness qualities, methods of implantation and system. US8262726. 5 Oct 2010. 11 Sep 2012. Transcend ...
... wireless device the width of a human hair that can be implanted in the brain and activated by remote control to deliver drugs. ... Read more about New brain implant delivers drugs via remote control on Business Standard. Researchers have developed a new ... New brain implant delivers drugs via remote control Press Trust of India , Washington. Last Updated at July 17, 2015 13:48 IST ... "With one of these tiny devices implanted, we could theoretically deliver a drug to a specific brain region and activate that ...
Researchers at USC are testing an implant that could control blood pressure without medication. Grandfather Tim Shockley is one ...
Remote-controlled drug delivery implant size of grape may help management of chronic diseases like arthritis, diabetes and ... New drug implant kept under the skin helps to individualize the drug dosage and schedule to every patient and it delivers drugs ... Drug Toxicity. Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, ... The drug dosage and schedule can be tailored to each patient, and the implant delivers the drugs for many months, even a year, ...
... to produce effective drug delivery devices and implants that are both identifiable, as well as traceable. Drug delivery devices ... a patient-specific drug delivery device can be custom-designed and additively manufactured in the form of an implant that can ... The identification and traceability of additively manufactured implants can be administered through radiofrequency ... identify, trace, and dispense a drug to the vicinity of a selected target tissue as a patient-specific function of time for ...
Cordis, a Cardinal Health company, and Medinol today announced that the first commercial cases using the EluNIR drug-eluting ... Cordis and Medinol Announce First U.S. Commercial Implants of Innovative EluNIR Drug-Eluting Stent. Deliverability of EluNIR ... Cordis, a Cardinal Health company, and Medinol today announced that the first commercial cases using the EluNIR drug-eluting ...
  • They were randomised to receive either the daily tablet plus a placebo implant or daily placebo tablets plus a naltrexone implant inserted subcutaneously in the abdominal under local anesthesia. (
  • The drug is injected into the device and then surgically implanted in the area being treated. (
  • Drugs can be injected into the sponge layer, which is surrounded by a polymer, allowing it to be surgically implanted into the body. (
  • A surgically implanted pump delivers medication in small, regular doses to maintain pain control. (
  • Dr. Paul Haber, Head of Drug Health Services at Royal Prince Alfred Hospital studied 12 patients who were admitted to hospital soon after receiving naltrexone in oral or implant form. (
  • Scientists in Europe have struggled to recruit patients for their DBS addiction studies, and complex ethical, social and scientific questions have made it hard to push forward with this kind of work in the United States, where the devices can cost $100,000 to implant. (
  • Nine years later, doctors at a military hospital in Xi'an reported that roughly half of the 1,167 patients who had their brains lesioned stayed off drugs for at least five years. (
  • The American Rhinologic Society thus feels strongly that drug-eluting implants are not investigational and should be available to our patients, when selected by the physician, in order to maximize outcomes. (
  • Among patients who took bisphosphonates, 1.88% had revision surgery during a median follow-up of 2.6 years compared with 4.36% of those not taking the drugs (HR 0.62, 95% CI 0.43 to 0.88), according to Daniel Prieto-Alhambra, PhD, of the University of Oxford, and colleagues. (
  • Because bisphosphonates seemed to help preserve implant survival through anti-osteoclast effects in an earlier U.K. cohort, his group conducted a validation study, analyzing outcomes among patients enrolled in national registries in Denmark. (
  • Among 80,000 patients ages 40 and up who had received joint implants between 1998 and 2007, 1,950 had used bisphosphonates for at least 6 months. (
  • Follow-ups took place with the patients between three and 67 months after the implant was done to see whether it had been successful. (
  • Unfortunately, because this study was based on data collected after the implants had been done rather than through interviews with incoming patients, it is impossible right now to determine the kind of SSRI dosage that could have this effect," says Tamimi. (
  • University of British Columbia researchers have developed a magnetic drug implant--the first of its kind in Canada--that could offer an alternative for patients struggling with numerous pills or intravenous injections. (
  • The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. (
  • Patients were randomized to receive drug coated balloon angioplasty (382 patients) or second-generation drug-eluting stent implantation (376 patients). (
  • Results show the device delivered dosages that were comparable to regular injections, with patients experiencing no adverse side-effects and many forgetting the implants were there. (
  • The nDS device provides controlled release of drugs without the use of pumps, valves or a power supply for possibly up to year without a refill for some patients. (
  • Some chronic disease drugs have the greatest benefit of delivery during overnight hours when it's inconvenient for patients to take oral medication. (
  • The FDA said Thursday that it had found a possible association between saline and silicone gel-filled breast implants and a rare cancer called anaplastic large-cell lymphoma, and that patients with implants may have a "very small but significant" risk of ALCL in the scar capsule adjacent to the implant. (
  • So far, the Microchips implant has been successfully used to dispense drugs to osteoporosis patients. (
  • While drug-eluting stents have been used successfully in millions of patients, evidence suggests that the body sometimes reacts to the stent with local inflammation that increases the risks of delayed healing and the formation of blood clots, a process known as stent thrombosis, which can lead to dangerous adverse events such as myocardial infarction (heart attack). (
  • Our results seem to suggest that differences are most prominent when use of dual antiplatelet therapy is low, which leads us to postulate that it may prove important for clinicians to ensure that patients who receive stent implants strongly inhibiting cell proliferation also receive an appropriate duration of dual antiplatelet therapy. (
  • The company says that oral epilepsy treatment is ineffective in 20% of patients, and that 30% to 40% of them are noncompliant with their drug regimen. (
  • The study found that the implant containing sustained-release naltrexone, a drug that blocks the effects of opiates and reduces cravings, was superior to daily oral naltrexone (the formulation currently approved by the Commonwealth Therapeutic Drugs Administration) in reducing relapse to regular heroin use among previously heroin dependent patients, according to the first randomised, placebo controlled study of this drug formulation. (
  • Intravitreal, subconjunctival, and peri-ocular routes of administration for these implants are quickly becoming popular among ophthalmic providers and their patients. (
  • Major concerns have been raised with regard to the safety of drug-eluting stents (DES) in patients with ST-elevation acute myocardial infarction (STEMI). (
  • The objective of this prospective study is to measure the completeness of strut coverage and vessel wall response to the ENDEAVOR zotarolimus-eluting stent vs the DRIVER stent (bare metal stent of identical metallic platform) implanted in STEMI patients. (
  • In turn, the researchers hoped that their findings would facilitate more accurate evidence-based counseling about implants between doctors and patients. (
  • While they acknowledged that the absolute risk was low, researchers encouraged doctors to closely monitor their breast implant patients for any signs of BIA-ALCL. (
  • They also strongly suggested that doctors discuss the risk of BIA-ALCL with patients who are considering breast implants. (
  • This randomized controlled trial compares postoperative pain and swelling after placing dental implants in patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs) versus NSAIDs and corticosteroids. (
  • Thirty patients received 5 dental implants each in the interforaminal region of the mandible. (
  • An injectable in situ forming implant with tuneable drug release kinetics would allow patients to replace some of their daily pills with a single infrequent injection. (
  • Aerie's first product, Rhopressa ® (netarsudil ophthalmic solution) 0.02%, a once-daily eye drop approved by the U.S. Food and Drug Administration (FDA) for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, was launched in the United States in April 2018. (
  • Over one third of patients receive insufficient benefit from oral anti-epileptic drug (AED) therapy, and continue to experience seizures whilst on medication. (
  • Fortis Health Care Ltd. And Another ( "the Petitioners" ) filed an application before the Excise & Taxation Commissioner, Punjab, Patiala Division, Patiala ( "the Commissioner" ), seeking advance determination of the question whether medicines, drugs, stents etc., administered to patients during a medical procedure ( "impugned goods" ) are a 'Sale', under the Punjab VAT Act, 2005( "Punjab VAT Act" ). (
  • Gothenburg, Sweden - Bacterial infections relating to medical implants place a huge burden on healthcare and cause great suffering to patients worldwide. (
  • Biofilms are more resistant than other bacteria, and the infections are therefore often difficult to treat, leading to great suffering for patients, and in the worst cases, necessitating removal or replacement of the implants. (
  • From January 2007 to January 2013, the dental research associations studied 916 dental implants in 490 patients who were treated with dental implants. (
  • These patients had a total of 94 implants. (
  • The Probuphine implant is designed to provide a constant, low-level dose of buprenorphine for six months in patients who are already stable on low-to-moderate doses of other forms of buprenorphine, as part of a complete treatment programme. (
  • PALO ALTO, Calif.--( EON: Enhanced Online News )--Intersect ENT, Inc., an innovator in treatment alternatives for ear, nose and throat clinicians and patients, today announced that the U.S. Food and Drug Administration (FDA) has approved the company's Premarket Approval (PMA) application for the Propel™ mometasone furoate implant offering localized, controlled drug delivery for chronic sinusitis patients. (
  • Safety and efficacy of the Propel implant has been studied in three prospective clinical trials conducted in the United States enrolling a total of 205 patients. (
  • Intersect ENT Inc., located in Palo Alto, Calif., is an innovator in local drug delivery focused on advancing clinically proven therapy alternatives that improve quality of life for ear, nose and throat patients. (
  • The company's initial focus is a dissolvable steroid-releasing implant to treat patients with chronic sinusitis, a common condition that affects one out of seven adults in the U.S. and greatly impacts quality of life. (
  • The company's drug-eluting device is designed to treat nasal polyp disease in patients who have undergone previous sinus surgery. (
  • This does not help the thousands of patients who have already suffered or have undergone (or will need to undergo) hip replacement revision surgery to replace the faulty implants. (
  • Patients suffered pain, immobility, or even hip implant revision surgery after being fitted with a potentially defective Wright Conserve hip. (
  • The implants have reportedly significantly alleviated pain in some patients. (
  • Pain patients considering requesting these implants should speak with their physicians to determine their suitability as candidates for this type of surgical procedure. (
  • Dr. Stuart Goodman, a neurosurgeon who has performed implant procedures, believes the technology also shows promise in assisting some Parkinson's Disease sufferers and some patients with peripheral neuropathies. (
  • The Zimmer NexGen CR-Flex implant was designed to give patients better range of motion than the customary NexGen device. (
  • Interestingly, the U.S. Food and Drug Administration did not make it a requirement for Zimmer to test the NexGen CR-Flex artificial knee implant system in patients prior to putting it on the market. (
  • In 2005, Dr. Berger, implanted the NexGen CR-Flex products in 125 patients. (
  • Within a year after implantation, these patients reported unusual pain associated with their NexGen CR-Flex knee implants. (
  • In 2006, Dr. Berger began noting evidence that the Zimmer knee implants were failing in his patients when X-rays showed evidence of loosening and failure of the implant. (
  • Several of his patients underwent revision surgeries that year due to failure of their knee implants. (
  • Angiographic and clinical outcomes of patients implanted with ultrathin, biodegradable polymer sirolimus-eluting stents versus durable polymer drug-eluting stents for percutaneous coronary intervention: an updated meta-analysis based on randomized controlled trials. (
  • In some subpopulations, including intravenous drug users and splenectomized patients, Gram-negative bacteria, including enteric bacteria, are significant pathogens. (
  • Recent research has indicated that mammograms should not be done with any greater frequency than that used in normal procedure in patients undergoing breast surgery, including breast implant, augmentation, mastopexy, and breast reducation. (
  • This Monday, Oct. 29, 2018, photo shows a brain scan of a methamphetamine user with the path of electrodes that doctors at Ruijin Hospital in Shanghai, China implanted to stimulate an area of the brain associated with addiction. (
  • A removable balloon is as good as a permanent stent implant for opening small blocked arteries, according to late breaking results from the BASKET-SMALL 2 trial presented in a Hot Line Session today at ESC Congress 2018 and simultaneously published in The Lancet. (
  • The most recent study, titled ' Breast Implants and the Risk of Anaplastic Large-Cell Lymphoma in the Breast ,' was published on January 4, 2018, and comes from researchers who analyzed the population-based nationwide Dutch pathology registry. (
  • A 2018 CBS News investigation found medical industry insiders claiming that doctors made up to $30,000 conducting a simple, 30-minute outpatient procedure implanting a small pellet. (
  • She told CBS News in 2018 that her son, Brennen, texted her to tell her he had a drug problem. (
  • By Keith Epps The Free Lance-Star July 12, 2018 A confidential police informant purchased drugs from a Fredericksburg pharmacy. (
  • In addition to the eye being a sensitive area, the likelihood of complications increases when multiple surgeries are performed to remove the implant as well as insert it. (
  • In some cases the physician will place a drug delivery implant with pain medication during surgery to lessen post-operative pain, but then will remove the implant in the office as part of the post-operative care services. (
  • The disadvantage is at some time the physician must either remove the implant or remove and reinsert an implant. (
  • Additionally, the formation of a solid implant offers the opportunity to remove the implant in the event of adverse effects, an option that it not possible for injectable depot formulations. (
  • There is no practical way to remove the implant and misuse it. (
  • The US Drug Watchdog says, 'A landmark settlement has been reached on the recalled DePuy ASR metal on metal hip implant, we want to do everything possible to make certain all recipients are included in this settlement, and we want them to call us at 866-714-6466. (
  • The US Drug Watchdog says, 'The DePuy Pinnacle Hip Implant is a metal-on-metal hip implant, and we want to get every DePuy Pinnacle metal on metal hip implant recipient identified just in case the device fails in the future. (
  • If you, or a loved one has had a hip replacement involving the metal-on-metal hip implant called the DePuy Pinnacle please call us immediately at 866-714-6466, and we do not care of the hip implant device has failed yet, or not. (
  • We do not want any metal on metal hip implant recipient left holding the bag for something that should have never been their problem-but now is, and we want all DePuy Pinnacle metal on metal hip implant recipients to start getting blood tests for elevated levels of cobalt, and chromium in their blood. (
  • The US Drug Watchdog says, 'For more information about the DePuy Pinnacle hip implant, and issues related to metal on metal hip implants please call the US Drug Watchdog at 866-714-6466, and we really cannot emphasize enough how important it is to have family members, or friends to ask artificial hip implant recipients if they have a DePuy Pinnacle metal on metal hip implant. (
  • The US Drug Watchdog says, 'Symptoms of a DePuy Pinnacle metal on metal hip implant failure include pain, problems walking, swelling of the hip, lack of flexibility, or elevated levels of cobalt, or chromium in the recipients blood. (
  • These wireless strategies could help manage post-surgical infection or pave the way for eventual 'wi-fi' drug delivery, he added. (
  • The surgical method and novel implant are addressed to the trabecular meshwork, which is a major site of resistance to outflow in glaucoma. (
  • Effect of Steroid-Releasing Sinus Implants on Post-Operative Medical and Surgical Interventions: An efficacy meta-analysis. (
  • But what this study tells us is both that further work needs to be done in the field and that whether they are planning to have dental implants or hip or knee prostheses, SSRI users should consult their physicians and plan carefully to ensure that the surgical treatment is successful. (
  • Inserted by a physician to maintain the surgical opening, the spring-like implant expands to prop open the sinus and gradually delivers an advanced corticosteroid with anti-inflammatory properties directly to the sinus lining as the implant dissolves, according to the company. (
  • This emphasized the assumption that collagen extrudates could be used in vivo without surgical removal after drug depletion. (
  • Ophthalmologists use these types of implants for ocular disease treatment and surgical treatment enhancement options. (
  • Certain bacteria can form impenetrable surface layers, or 'biofilms', on surgical implants, such as dental and other orthopaedic implants, and represent a major problem for healthcare globally. (
  • You will receive this implant with a minor surgical procedure in a clinic or doctor's office. (
  • In surgical practice, for the reconstruction of a breast, the tissue expander device is a temporary breast prosthesis used to form and establish an implant pocket for the future permanent breast implant. (
  • However, these polymer-based systems often have limited drug-loading capacity, suboptimal release kinetics, and/or promote adverse inflammatory responses. (
  • Polymers such as polycaprolactone and poly(lactic-co-glycolic acid) (PLGA) have long been held as the gold standard polymer carrier systems for controlled drug delivery applications. (
  • Researchers in the U.K. have developed a technique to better predict results in liver cancer when drug-laden polymer beads are used to deliver medicines. (
  • The injectable implant is comprised of three elements - an organic solvent, a polymer, and the drug or drugs that need to be delivered. (
  • The AR-13503 implant is a bio-erodible polyesteramide polymer implant that provides controlled release of AR-13503 over a sustained period. (
  • polymer-based implants" by Amy J. Halliday, Simon E. Moulton et al. (
  • For example, an aqueous based medicament will degrade a biodegradeable polymer implant. (
  • Medical devices decorated with salicylic acid-based polymer chains (polymeric prodrug) that slowly release this anti-inflammatory and anti-biofilm drug at the implantation site were designed. (
  • The Iluvien device is a sustained release implant that delivers fluocinolone acetonide and is indicated to treat diabetic macular edema in people who have been previously given corticosteroids and did not have a clinically significant rise in intraocular pressure. (
  • Histrelin comes as an implant (a small, thin, flexible tube containing medication) that is inserted by a doctor on the inside of the upper arm. (
  • The doctor will use a medication to numb the arm, make a small cut in the skin, then insert the implant subcutaneously (just under the skin). (
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (
  • An early test of a new drug and method of blocking HIV infection suggests they could overcome one of the biggest obstacles to combating the virus by keeping people on their medication, according to research released Tuesday. (
  • The approach uses a small implant the size of a matchstick, inserted in the upper arm, to slowly release a new medication that appears to block the virus for a year or more. (
  • Once the medication runs out, the implant can be removed and replaced in a visit to a doctor's office, he said. (
  • Merck is also looking into the possibility of using the same drug as an oral medication to treat HIV infections, Hanna said. (
  • Our Implanon Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (
  • Drug delivery devices can potentially be used for drug release in the direct vicinity of target tissues or the selected medication route in a patient-specific manner as required. (
  • Goserelin implant may also be used for purposes not listed in this medication guide. (
  • Due to the size and constraints of the eye, an ophthalmologist can use a non-biodegradeable implant reservoir or a sub-conjunctival, intrascleral, or intravitreal implant to deliver a drug or medication directly to targeted areas within the eye and/or the surrounding eye structures. (
  • Non-biodegradeable implants offer the advantage of a constant or steady controlled release of a drug or medication for a long or extended period of time, ranging from days to years. (
  • The self-expanding implant conforms to the highly variable sinus anatomy then effectively delivers anti-inflammatory medication where it's needed most as the implant dissolves. (
  • Goserelin comes as an implant to be inserted with a syringe subcutaneously (under the skin) in your stomach area by a doctor or nurse in a medical office or clinic. (
  • The present invention relates to a device for inserting or implanting a solid or semisolid drug or cell delivery implant subcutaneously, interstitially or intramuscularly. (
  • Birth Control Implant is a long-acting birth control contraceptive inserted into the arm. (
  • Such an implant could be used to dispense a whole range of useful drugs - but in this case, one of the first commercial applications will be the contraceptive hormone levonorgestrel, which is already used by a number of female birth control methods. (
  • currently, no implanted contraceptive works for more than five years. (
  • Now, with the Gates Foundation getting involved, the new contraceptive version of the implant is being developed. (
  • The subdermal contraceptive implant and the 52-mg levonorgestrel intrauterine device are currently Food and Drug Administration approved for 3 and 5 years of use, respectively. (
  • We sought to evaluate the effectiveness of the contraceptive implant and the 52-mg hormonal intrauterine device in women using the method for 2 years beyond the current Food and Drug Administration-approved duration. (
  • We are enrolling women using the contraceptive implant or 52-mg levonorgestrel intrauterine device for a minimum of 3 and 5 years, respectively (started intrauterine device in ≥2007 or implant in ≥2009). (
  • This study indicates that the contraceptive implant and 52-mg hormonal intrauterine device continue to be highly effective for at least 2 additional years of use. (
  • 1 68-mg implant, contraceptive effect lasts for 3 yr. (
  • If switching from a progestin-only method, insert any day of the mo when switching from a progestin-only pill (do not skip any days between last pill and insertion), on the same day as contraceptive implant removal, on the same day as removal of a progestin-containing IUD, or on the day when the next contraceptive injection would have been. (
  • Norplant : contraceptive subdermal implants, manual for clinicians. (
  • Norplant : contraceptive subdermal implants : guide to effective counseling. (
  • Choice and challenge : global teamwork in developing a contraceptive implant. (
  • Norplant contraceptive subdermal implants : managerial and technical guidelines. (
  • What is new and promising with drug-eluting stents in sinus surgery? (
  • Trends in the use of stents and drug-eluting stents in sinus surgery. (
  • BASKET-SMALL 2 is the largest randomized trial to examine whether drug coated balloons are as good as drug-eluting stents for opening small arteries that have become blocked for the first time. (
  • The study, which is being presented at the European Society of Cardiology (ESC) 2012 Annual Congress, examined the effects in the patient of two drug-eluting stents with different healing characteristics (the Endeavor™ zotarolimus-eluting stent, E-ZES, and the Cypher™ sirolimus-eluting stent, C-SES). (
  • These scaffold-like medical devices are placed into narrowed arteries to prevent the artery from becoming blocked, and, unlike earlier devices (so-called bare metal stents) which provided purely structural support, are able to slowly release a drug that reduces the cell proliferation, which may otherwise lead to an exuberant scar formation at the site of the stent and narrowing or even occlusion of the vessel. (
  • In addition, the authors have dispelled the misconception that the in-stent tissue growth (thickening of the arteries) associated with less effective drug eluting stents confers lower risk for stent thrombosis. (
  • Whether sirolimus -eluting stents constituted with ultrathin-strut and biodegradable polymers (BP-SESs) can achieve a preferable effect over current drug-eluting stents with durable polymers (DP-DESs) remains highly controversial. (
  • Because many addicts do not stick to the regular doses prescribed the effectiveness of the drug is often compromised. (
  • The implant was used to deliver 20 individually sealed doses of an osteoporosis drug called teriparatide (parathyroid hormone). (
  • Continuous, fixed doses of chronic disease medications used for arthritis, diabetes and heart disease were successfully delivered with the help of grape-sized drug implant by the researchers from Houston Methodist using a nanochannel delivery system (nDS) that was remotely controlled by Bluetooth technology. (
  • The MIT team's next-generation approach: a customizable deep-brain implant that can deliver varying doses of more than one drug on demand. (
  • Instead of relying on the patient to take the correct medications, this tiny implanted pharmacy can be programmed to deliver drugs automatically in the right doses at the right times. (
  • Best of all, the implant can be controlled wirelessly, allowing the Doctor to change dosage or the timing of doses at any time. (
  • The implants, called Probuphine, were approved by the FDA in 2016. (
  • In 2016, the World Health Organization (WHO) validated the FDA's suspicions, designating BIA-ALCL as a T-cell lymphoma that can develop from breast implants. (
  • Saliva enters the reservoir via a membrane, dissolves part of the solid drug and flows through a small duct into the mouth cavity, where it is absorbed by the mucous membranes in the patient's cheeks. (
  • Given by subcutaneous injection, the biodegradable implant slowly dissolves, delivering therapeutic levels of the drug continuously over a period of 12 weeks. (
  • Interested in a Discount on Carmustine Implant? (
  • ALIM ) said last month that it won approval in Canada for its intravitreal implant designed to treat diabetic macular edema. (
  • The U.S. Food and Drug Administration (FDA) sounded the alarm on July 6, 2019. (
  • In March of the same year, the FDA held a public advisory committee meeting to further explore the many concerns stemming from this issue, and on July 24, 2019, the agency requested a voluntary recall of breast implant maker Allergan's textured breast implants, noting that the risk of BIA-ALCL with these medical devices was six times higher than with those from other manufacturers. (
  • Using COMSOL® Multiphysics, we modeled the delivery of betamethasone phosphate (BP) from a biodegradable implant that is placed in the scleral layer of a human eye. (
  • Report the insertion and/or removal of the non-biodegradable implant separately. (
  • Researchers from Tufts University have demonstrated an electronic implant - composed of silk and magnesium - that eliminated bacterial infection in mice by delivering heat to infected tissue when triggered by a remote wireless signal. (
  • The new drug, islatravir, and the implant were developed by the drug company Merck and described at a news conference at an international gathering of HIV researchers in Mexico City. (
  • The researchers reached this conclusion by looking back over the records of dental implants done over a six-year period, between 2007 - 2013, in a clinic in Moncton, New Brunswick. (
  • The researchers tested their device on animal tissue in the lab using the prostate cancer drug docetaxel. (
  • Researchers have developed a new wireless device the width of a human hair that can be implanted in the brain and activated by remote control to deliver drugs. (
  • As part of the study, the researchers showed that by delivering a drug to one side of an animal's brain, they could stimulate neurons involved in movement, which caused the mouse to move in a circle. (
  • A proof-of-concept paper recently published in Lab on a Chip explains how the Houston Methodist nanomedicine researchers accomplished long-term delivery of drugs for rheumatoid arthritis and high blood pressure, medications that are often administered at specific times of the day or at varying dosages based on patient needs. (
  • Researchers at the University of British Columbia (UBC) have developed Canada's first magnetic drug implant as an alternative mode of drug delivery. (
  • In testing the device, the researchers found that it was able to repeatedly deliver the drug every time the magnet was passed over the animal tissue. (
  • These researchers also found that 82% of the women in the study with BIA-ALCL had 'macrotextured' implants, while the remaining 18% had 'microtextured' implants. (
  • The results of the Dutch researchers also echoed those of previous studies as regards the relatively low overall risk of developing BIA-ALCL after breast implants. (
  • Researchers at Houston Methodist Hospital in Texas have developed a remote-controlled nanofluidic drug delivery implant, the nanochannel delivery system (nDS), for treatment of chronic diseases. (
  • Researchers implanted the needle into a movement-related brain region that Parkinson's disease damages. (
  • UNC researchers have created an injectable multi-drug delivery system that is removable, biodegradable and effective for up to a year in some cases. (
  • Targeting HIV treatment and prevention, researchers across multiple departments at the University of North Carolina at Chapel Hill collaborated on a seven-year study in animals to make a better injectable drug implant that can combine multiple drugs and is ultra-long-acting, while also addressing many of the challenges faced with current HIV treatment and prevention methods. (
  • Researchers plan to continue developing and improving this multi-drug delivery system, observing its effects in relevant in vivo models and eventually humans. (
  • The researchers also told MNT that the technology could be used in controlled drug release. (
  • Histrelin implant (Vantas) is used to treat the symptoms associated with advanced prostate cancer. (
  • Histrelin implant (Supprelin LA) when used in children with precocious puberty, will likely be stopped by your child's doctor before 11 years of age in girls and 12 years of age in boys. (
  • Sometimes histrelin implant is hard to feel under the skin so the doctor may have to use certain tests, such as ultrasound or MRI scans (radiology techniques designed to show the images of body structures) to find the implant when it is time to remove it. (
  • Occasionally, histrelin implant may come out through the original insertion site on its own. (
  • What is Histrelin (Implant)(Subcutaneous) used for? (
  • Can I take Histrelin (Implant)(Subcutaneous) if I'm pregnant or breastfeeding? (
  • Use Histrelin (Implant)(Subcutaneous) exactly as directed on the label, or as prescribed by your doctor. (
  • The histrelin implant is inserted using a special tool that pushes the implant into place through the incision in your skin. (
  • Polymeric drug carriers are widely used for providing temporal and/or spatial control of drug delivery, with corticosteroids being one class of drugs that have benefitted from their use for the treatment of inflammatory-mediated conditions. (
  • This manuscript investigates and describes a strategy for achieving controlled delivery of corticosteroids, based on a discovery that low molecular weight corticosteroid dimers can be processed into drug delivery implant materials using a broad range of established fabrication methods, without the use of polymers or excipients. (
  • In this study, we report on the use of low molecular weight corticosteroid dimers that possess many qualities required of an ideal drug delivery system. (
  • Actively controlling drug delivery is particularly relevant for conditions like diabetes, where the required dose and timing of insulin varies from patient to patient, said co-author John K. Jackson, a research scientist in UBC's faculty of pharmaceutical sciences. (
  • Active regulation of on-demand drug delivery by magnetically triggerable microspouters" was recently published online in the journal Advanced Functional Materials . (
  • Scientists at the Massachusetts Institute of Technology (MIT) developed a novel system of drug delivery using deep-brain implant technology. (
  • The new tech is called the 'miniaturized neural drug delivery system' (MiNDS). (
  • You can do remote control delivery, you can do pulsatile drug delivery, and you can deliver multiple drugs. (
  • Current drug delivery devices, such as pain or insulin implants, rely on pumping mechanisms or external ports and typically need refills every couple of months. (
  • The purpose of this study is to demonstrate the ability of additive manufacturing, also known as 3D printing, to produce effective drug delivery devices and implants that are both identifiable, as well as traceable. (
  • As a result of this study, a patient-specific drug delivery device can be custom-designed and additively manufactured in the form of an implant that can identify, trace, and dispense a drug to the vicinity of a selected target tissue as a patient-specific function of time for bodily treatment and restoration. (
  • Akmal JS, Salmi M, Mäkitie A, Björkstrand R, Partanen J. Implementation of Industrial Additive Manufacturing: Intelligent Implants and Drug Delivery Systems. (
  • I believe the combination of minimally invasive techniques and local drug delivery will be the wave of the future in sinus treatment. (
  • Besides this, collagen was physically or chemically cross-linked in some experiments to further restrict collagen digestion and drug delivery. (
  • It was shown that model compounds like BSA or FITC dextran 20, 70 and 150, respectively, could be incorporated and that their delivery could be controlled by the used collagen matrix material, e.g. animal source or cross-linking degree, the matrix dimensions (length or diameter of the extrudates), the molecular weight of the incorporated model compound and the drug load. (
  • The in vitro release of FITC dextrans and BSA was investigated and delivery of 80% model drug was in the range between 7h and 5d. (
  • A new drug delivery alliance aims to overcome the obstacle by bypassing it all together. (
  • Infusion pump specialist Flowonix Medical of Mount Olive, NJ, just announced that it aims to develop an implanted drug delivery system for direct administration of Cerebral Therapeutics' small molecule candidates into the brain. (
  • It appears that refractory epilepsy will be the main target of the drug delivery alliance. (
  • Cerebral Therapeutics chose to work with Flowonix because the Prometra and Prometra II infusion pumps offer a patented valve-gated drug delivery system which allows for very precise dosing of medicine,' said Cerebral CEO Dr. Dan Abrams in a statement. (
  • He added that clinical trials will be needed to demonstrate the benefits of targeted drug delivered directly to the brain, and said intraspinal delivery has shown the advantages of a direct approach to administration. (
  • Currently, most ocular implants that are used for sustainable drug delivery are non-biodegradable. (
  • We used a 2D axisymmetric geometry to represent the eye with the implant and focused on the delivery of BP to the retina. (
  • Upon finding that BP concentration exceeded the desired range in the retina, we optimized the location and size of our implant for drug delivery in the human eye. (
  • Our results suggest that this biodegradable ocular implant is a viable option for drug delivery in the human eye. (
  • Drug delivery implants are designed to provide active pharmaceuticals to a targeted area in into the patient's body for a certain length of time site. (
  • Coders continue to struggle with coding for drug delivery implants. (
  • Although CPT ® did not make many changes to these codes for 2012, coders must understand how to correctly report drug delivery implant codes. (
  • In the orthopedic specialty, physicians commonly use drug delivery implants. (
  • Many of the new implanted non-biodegradeable delivery systems use a nonreactive outer shell, such as silicon or ethylene vinyl acetate (EVA) to house the drugs such as antibiotics, anti-inflammatories (steroids), and antivirals. (
  • If you choose to use an unlisted CPT code, be prepared to document why the unlisted code is a better choice than using a CPT code designated for the use of a drug delivery implant. (
  • This small nDS is powered by battery, wireless Bluetooth is used to control drug delivery once it is implanted under the skin, and the electric charge can be modified to increase or decrease the concentration driven diffusion across a nanofluidic membrane. (
  • The plan: Thread the pumps somewhere under the skin for a fully implantable system, dubbed MiNDS for miniaturized neural drug delivery system. (
  • There is no FDA-approved or marketed technology for long-acting prevention of HIV, and we are the first to use this delivery method with multiple antiretroviral drugs," said Rahima Benhabbour, PhD, MSc, first author of the study and assistant professor in the UNC_NCSU Joint Department of Biomedical Engineering. (
  • Because one of the biggest difficulties associated with HIV prevention is lack of adherence to drug treatment, we wanted to create a drug delivery system that essentially solved this problem," said senior author J. Victor Garcia, PhD, professor of medicine at UNC School of Medicine, director of the International Center for the Advancement of Translational Science and member of the UNC Center for AIDS Research. (
  • The injectable drug implant created by UNC's research team is the first to address several drawbacks to the current method of long-acting drug delivery for HIV - namely the ability to remove it and quickly eliminate the presence of residual drug(s) in the system. (
  • The eye presents several anatomic and physiologic barriers that pose a major challenge for targeted drug delivery. (
  • Thus, the development of effective delivery systems depends upon the understanding of how the ocular barriers affect the pharmacokinetics of drugs. (
  • In Part 1, investigation of the barriers to transscleral drug delivery was performed in a rabbit model, and the model demonstrated that the conjunctival lymphatic and blood vessels may be a predominant barrier to the delivery of triamcinolone acetonide to the vitreous. (
  • A range of technologies have been developed to provide long acting drug delivery, these include microparticles, 7 nanoparticles, 8 nanosuspensions, 9,10 oils 4 and in situ forming implants. (
  • ISFIs are an attractive approach to providing long-acting drug delivery as they are easily administered and can be tuned to provide varying rates of drug release. (
  • The AR-13503 implant marks our second foray into the retina space, with this product candidate leveraging both our scientific leadership in the creation of small-molecule kinase inhibitors for disease intervention along with our proprietary ophthalmic drug delivery platform. (
  • Future designs for drug delivery system and aqueous humor shunting between the vitreous cavity to the subarachnoidal space and orbit deserves to be explored. (
  • More particularly, the invention relates to a device for loading a solution, suspension, a flowable phase or a solid into a delivery implant at the time of use followed by implantation of the implant under the surface of the skin or within the muscle of a human or animal. (
  • The implant-mediated drug delivery system (IMDDS) is a novel, innovative device that allows drug delivery through bone marrow. (
  • Modified titanium implant as a gateway to the human body: the implant mediated drug delivery system. (
  • New application of endosseous implants-implant mediated drug delivery system (IMDDS). (
  • Novel route of insulin delivery using an implant-mediated drug delivery system. (
  • Dexamethasone delivery by an implant-mediated drug delivery system in the canine mandible. (
  • The sustained effects on tear volume of pilocarpine hydrochloride in gelatin by hydrogel administered by an implant-mediated drug delivery system. (
  • Weiss M, Fischer J, Neff T, Baenziger O. The effects of syringe plunger design on drug delivery during vertical displacement of syringe pumps. (
  • Need Drug Delivery Business News in a minute? (
  • Drug Delivery Enewsletters get you caught up on all the mission critical news you need in med tech. (
  • New drug implant kept under the skin helps to individualize the drug dosage and schedule to every patient and it delivers drugs for long duration of time even upto a year, before refills are needed. (
  • The drug dosage and schedule can be tailored to each patient, and the implant delivers the drugs for many months, even a year, before refills are needed. (
  • In today's Save Our Bones Bulletin, you'll read about a new experimental implant that delivers electric currents to muscles, aiming to increase bone density. (
  • Dr. Haber says such severe adverse events challenge the notion that naltrexone implants are a safe procedure and says there is a need for careful case selection, careful clinical management, and for closer regulatory monitoring. (
  • There are eight registered DBS clinical trials for drug addiction being conducted in the world, according to a U.S. National Institutes of Health database. (
  • In February, the U.S. Food and Drug Administration greenlighted a clinical trial in West Virginia of DBS for opioid addiction. (
  • This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. (
  • Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and challenges. (
  • Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. (
  • Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. (
  • This is a long-awaited milestone in clinical evidence for the drug coated balloon technique, which so far has primarily been used for the treatment of in-stent restenosis. (
  • The implant provides an extended therapeutic period during which heroin addicts can alter their lifestyle, said lead author, Winthrop Professor Gary K. Hulse, Professor of Addiction Medicine, School of Psychiatry and Clinical Neurosciences, at The University of Western Australia. (
  • Do not drop these on the floor," she says, ribbing her two clinical assistants as they pass her the implants. (
  • as well as] increased clinical awareness, comprehensive registration of implants and complications, and stimulation of alternative cosmetic/reconstructive procedures. (
  • We are now planning trials where we will explore binding other hydrophobic molecules and drugs with even greater potential to treat or prevent various clinical infections," says Santosh Pandit. (
  • Last week, the FDA gave Titan the green light to conduct clinical trials of the ropinirole implant. (
  • The surgery involves implanting a device that acts as a kind of pacemaker for the brain. (
  • Passing a magnet over the patient's skin activates the device by deforming the sponge and triggering the release of the drug into surrounding tissue through a tiny opening. (
  • The drug also produced an effect on cancer cells comparable to that of freshly administered docetaxel, proving that drugs stored in the device stay effective. (
  • The Houston Methodist device is implanted under the skin and uses a nanofluidic membrane made with similar technology used in the silicon semiconductor industry. (
  • According to Bloomberg Business week on November 12th 2013, 'Johnson & Johnson (JNJ) will pay more than $4 billion to resolve thousands of lawsuits over its recalled hip implants in the largest settlement of U.S. legal claims for a medical device.The accord will resolve more than 7,500 lawsuits in federal and state courts against J&J's DePuy unit. (
  • The implanted device, developed by the rather unimaginatively named Microchips in Lexington, is 20mm (0.8in) square and 7mm thick. (
  • Contained within the device is a microchip (thus the company's amazing name) that contains a series of drug reservoirs. (
  • The US Drug Watchdog is the premier medical device, and pharmaceutical watchdog, and advocate in the United States. (
  • The group says, 'We want to make certain all metal-on-metal DePuy Pinnacle hip implant victims get to the actual trial law firms, or attorneys, that have the best record in achieving superior results for their clients, in these types of medical device lawsuits. (
  • In the Refusal to File letter, the FDA indicated among other things, that XARACOLL should be characterized as a drug/device combination, which would require that the Company submit additional information. (
  • The amount of drug released by the device is controlled by passing a magnet over the site of implantation. (
  • The magnet triggers the release of the drug from the spongey interior, which flows into the surrounding tissue through a small opening in the device. (
  • They also found that the effectiveness of the drug was not diminished despite being stored in the implanted device. (
  • According to the most recent BIA-ALCL update from the FDA , 414 medical device reports (MDRs) related to breast implants and ALCL have been filed. (
  • Sign up for our e-mail newsletter for a weekly dose of drug-device news. (
  • According to a recent press release by MIT News an implantable, microchip-based device may soon replace the injections and pills now needed to treat chronic diseases: Earlier this month, MIT spinout Microchips Biotech partnered with a pharmaceutical giant to commercialize its wirelessly controlled, implantable, microchip-based devices that can store and release drugs inside the body over many years. (
  • In some cases, the only way to alleviate the symptoms of Wright hip implant failure is to remove and replace the faulty device in a painful and costly operation. (
  • The Zimmer NexGen Knee Implant is not a specific device, but rather a family of devices. (
  • Within this NexGen device family, there are different models of implants: NexGen CR-Flex, NexGen LPS-Flex, NexGen High Flex, NexGen LPS, NexGen MIS. (
  • The agency had received 573 medical device reports (MDRs) of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). (
  • An early version of the implant has been trialled on seven women with the bone-thinning disease osteoporosis, with the results published in the journal Science Translational Medicine. (
  • The implants are usually inserted into the abdominal wall and release the drug over several months. (
  • These implants undergo surface erosion, achieving tightly controlled and reproducible drug release kinetics in vitro. (
  • Beginning in the 1960's, biostable and biodegradable polymers were introduced to formulate drugs into implants with controlled release profiles. (
  • There have been a number of well-controlled studies on drug-eluting implants in the paranasal sinuses, specifically implants that release steroids to the local tissues. (
  • Upon implantation of the implant within a body, the therapeutic agent is released and the bioerodible metal portion erodes to release polyvalent metal cations capable of re-cross-linking the polysaccharide matrix. (
  • Video shows a magnetically triggered, controlled drug release. (
  • To prove the technology worked as planned, the microchip was programmed for three different drug release settings - standard, decreased and increased. (
  • With each setting, a specific voltage was applied to a silicon nanochannel within the implant to control drug release. (
  • The developed collagen devices were used to investigate the enzymatic collagen matrix degradation and the release of higher molecular weight drugs, e.g. proteins. (
  • Based on the obtained in vitro results a mathematical model was developed to describe drug release from collagen matrices undergoing enzymatic degradation. (
  • Equations for the collagen degradation and the drug release were implemented, adsorption and diffusion phenomena were incorporated and a mixture of experimentally determined and fitted parameters was used to feed the model. (
  • They contain the opioid dependence treatment drug buprenorphine and release it in a slow, steady dose over the course of six months. (
  • The implant's bulk erosion and mass transfer dynamics resulted in an initial spike of BP release followed by a slow, gradual depletion of the remaining drug. (
  • The model was validated with experimental data for BP release from implants in the rabbit eye, which is an accurate model for drug pharmacokinetics in the human eye. (
  • In this study, sol-gel titania implants used in the controlled rate of drug release of valproic acid to the temporal lobe of the brain were optimized to insure that the correct drug dose is delivered. (
  • In previous studies we have reported that the rate of drug release to the temporal lobe of Wistar rats is dependent on (a) porosity and, (b) chemical linteractions between valproic acid and the surface hydroxyl groups of titania. (
  • Characterization studies were performed using both TEM and BET. Kinetic studies on the rate of drug release were also performed. (
  • It can provide the continuous controlled release of drugs without the use of pumps, valves or a power supply potentially for up to 12 months. (
  • In this study six antiretroviral drugs were tested, and all kept their physical and chemical properties within the formulation and upon release. (
  • In this work, we investigate how the size of poly( N -isopropylacrylamide) (polyNIPAm) nanogels influences the long-acting release behaviour of the HIV drug lopinavir from an in situ forming implant. (
  • The drug release behaviour and stability of these nanocomposite implants were then assessed in vitro over 360 hours. (
  • All samples displayed a single phase of drug release and application of the Ritger-Peppas equation indicated Fickian diffusion. (
  • These results show an attractive method for tuning the release of lopinavir from in situ loading implants with high drug loadings. (
  • Glaucoma drainage devices (GDD) pose an opportunity to introduce a drug-eluting mechanism for long term release of low dose antifibrotics. (
  • It may therefore be useful for drug-release applications in GDD. (
  • A system for injecting controlled release medicinal implants has a syringe-like injector body with a lumen and plunger. (
  • The release patterns of each group were monitored for 2 weeks by measuring the plasma concentration of the drug. (
  • Both groups showed sustained release of drug. (
  • The incorporation of a SAP active plunger component in the IMDDS resulted in an increase in initial release of drug and higher bioavailability within the observation period of 2 weeks after dexamethasone administration. (
  • Our aimed was to identify a new preventive strategy to control drug release, biofilm formation and contamination of medical devices with microbes. (
  • Purpose: To determine local ocular tissue levels of the bile acid, tauroursodeoxycholic acid (TUDCA), in the pig model using oral, intravenous (IV), intravitreal injection (IVitI) and low- and high-dose suprachoroidal, sustained-release implants (SCI-L or SCI-H). Methods: Forty-six pigs (92 globes) were included in the study. (
  • Goserelin implant is used in combination with radiation therapy and other medications to treat localized prostate cancer and is used alone to treat the symptoms associated with advanced prostate cancer. (
  • Goserelin implant is in a class of medications called gonadotropin-releasing hormone (GnRH) agonists. (
  • An implant with 3.6 mg of goserelin is usually inserted every 4 weeks. (
  • Your doctor will determine how long you should use goserelin implant. (
  • Goserelin may cause an increase in certain hormones in the first few weeks after insertion of the implant. (
  • Goserelin implant should not be used in pregnant women, except for treatment of advanced breast cancer. (
  • Goserelin implant may harm the fetus.You should not plan to become pregnant while using goserelin implant or for 12 weeks after your treatment. (
  • Your doctor may perform a pregnancy test or tell you to begin your treatment during your menstrual period to be sure that you are not pregnant when you begin using goserelin implant. (
  • You will need to use a reliable nonhormonal method of birth control to prevent pregnancy while you are using goserelin implant and for 12 weeks after your treatment. (
  • You should not breast-feed during your treatment with goserelin implant. (
  • If you miss an appointment to receive an implant of goserelin, you should call your healthcare provider right away to reschedule your appointment. (
  • Goserelin implant may cause side effects. (
  • Goserelin implant is used in men to treat symptoms of prostate cancer . (
  • Goserelin implant is used in women to treat breast cancer or endometriosis . (
  • Unless you are being treated for advanced breast cancer, you should not use a goserelin implant during pregnancy. (
  • Goserelin implant is inserted through a needle into the skin of your upper stomach, once every 28 days. (
  • The new formation, 10.8 mg goserelin acetate implant given every three months, offers greater convenience to subjects choosing treatment with a luteinizing-hormone-releasing hormone (LHRH) analogue. (
  • The 3-month formulation of Zoladex is a cylindrical implant with a 1.5 mm diameter that contains 10.8 mg of goserelin. (
  • I like trying new things," Atkinson says of her decision to learn the Probuphine implant procedure. (
  • The Probuphine implant consists of four, one-inch-long rods that are implanted under the skin on the inside of the upper arm and provides treatment for six months. (
  • The FDA is requiring postmarketing studies to establish the safety and feasibility of placing the Probuphine implants for additional courses of treatment. (
  • The Delray Center now offers Probuphine implants for the treatment for opioid dependence. (
  • Probuphine is the first and only Buprenorphine implant that lasts 6-months. (
  • Once a patient has reached at least 3 months of abstinence from illicit drugs and is stable on 8mg a day of buprenorphine, they are a candidate for Probuphine. (
  • Probuphine consists of 4 small rod shaped implants that are placed under the skin on the inside of the arm below the biceps. (
  • Implant technology, which has been used in other medical treatments for a number of years, has been combined with Buprenorphine to create Probuphine. (
  • The Probuphine implant consists of 4 soft, flexible rods, that are 26mm (approximately 1 inch) in length each. (
  • The Probuphine implant is removed after 6 months. (
  • Never try to remove the Probuphine implant on your own. (
  • Opioid withdrawal will also develop after the Probuphine implant is removed, if it is not replaced with a new implant. (
  • Drinking alcohol with a Probuphine implant can lead to drowsiness , slowed reaction time, slowed breathing, fainting, and possibly death. (
  • If you have more questions about Probuphine implants for the treatment for opioid dependence, please contact our office. (
  • Upon implantation of the implant within a body, the therapeutic. (
  • Thousands of women over the years have undergone a non-invasive procedure to receive an Essure birth control implant. (
  • If you are one of thousands of women negatively impacted by the Essure birth control implant , you may be entitled to compensation for medical expenses and more from the manufacturer. (
  • 0.01), bone augmentation (P=0.04), and small implant diameters (P=0.01 for 4mm or less). (
  • In reconstructive plastic surgery, breast implants can be placed to restore a natural looking breast following a mastectomy, to correct congenital defects and deformities of the chest wall or, cosmetically, to enlarge the appearance of the breast through breast augmentation surgery. (
  • The operating room (OR) time of post-mastectomy breast reconstruction, and of breast augmentation surgery is determined by the procedure employed, the type of incisions, the breast implant (type and materials), and the pectoral locale of the implant pocket. (
  • In Part 2, the pharmacokinetics of a cyclosporine episcleral implant for high-risk penetrating keratoplasties was also studied, and the implant was safe and effective at delivering therapeutic levels to the cornea and surrounding tissues. (
  • Implant users were offered periodic venipuncture for analysis of serum etonogestrel levels. (
  • Among implant users with serum etonogestrel results, the median etonogestrel level was 207.7 pg/mL (range 63.8-802.6 pg/mL) at the time of method expiration, 166.1 pg/mL (range 67.9 25.0-470.5 pg/mL) at the end of the fourth year, and 153.0 pg/mL (range 72.1-538.8 pg/mL) at the end of the fifth year. (
  • Sinus implants for chronic rhinosinusitis: technology evaluation. (
  • Palo Alto, CA-based Intersect ENT has earned FDA premarket approval for its Propel drug-eluting implant for treatment of chronic sinusitis. (
  • Chronic Pulmonary Silicone Embolism Related to Saline Breast Implants. (
  • Chronic silicone embolism syndrome due to PIP breast implant leakage - a new entity? (
  • Now, the development of innovative spinal cord stimulating implants offers hope for people seeking relief from certain types of chronic leg and lower back pain. (
  • According to court records there are approximately 30,000 US citizens who have the recalled DePuy ASR all metal hip implant, and according to the news article detailing the settlement only 7500 recipients have been identified by the court. (
  • The US Drug Watchdog has been urging recipients of the recalled Depuy ASR all metal hip implant to call them about suggested law firms so they could be included in a possible settlement for three years. (
  • A settlement has just been announced, and it is absolutely vital all recipients of the DePuy ASR all metal hip implant call them at 866-714-6466, if they have not already been identified by the federal court handling this litigation. (
  • The US Drug Watchdog says, 'According to court records 30,000 US citizens are recipients of the DePuy ASR all metal hip implant. (
  • Our hope is to get all recipients of the recalled DePuy ASR all metal hip implant identified, and compensated. (
  • In some cases, recipients of Wright hips have even been diagnosed with a dangerous form of metal toxicity known as metallosis, which is a result of small shards of chromium and cobalt entering the blood after they are released from the metal implant parts. (
  • It doesn't take much reading between the lines to realize that the exact cause of this lymphoma in breast implant recipients is still unknown. (
  • Drug Injury Watch: March 2017 FDA Report: Breast Implants Linked To Lymphoma Blood Cancer (
  • additional information on the risk of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) has been released. (
  • Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) is a type of non-Hodgkin's lymphoma, which is a cancer of the cells of the immune system. (
  • Dr. Kate Atkinson injects Jamey Summers with a local anesthetic to numb his arm before inserting four buprenorphine implants at her office in Amherst. (
  • Scientists have tested a wirelessly controlled microchip that is designed to be implanted into a patient's body and programmed to deliver drugs. (
  • The patient's body will not absorb a non-biodegradeable implant, and at some point in time, a physician will need to remove it from the body. (
  • We effectively gave people both an implant and an oral formulation where one was active and no one knew which formulation was given,' said Professor Hulse. (
  • 11 In situ forming implants (ISFIs) consist of an injectable drug formulation that solidifies after injection into the body to form a matrix with an embedded drug. (
  • The original 3.6 mg formulation of Zoladex has been available since 1989 as a monthly implant. (
  • One of the standard treatments for opening blocked arteries is to insert an expandable metal tube (stent) covered with drugs via a catheter. (
  • Balloons covered with drugs, also inserted using a catheter, are approved in Europe to reopen stented arteries that have become blocked a second time. (
  • The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. (
  • You will wear an abdominal binder for six weeks after surgery to promote proper healing of catheter placement and implanted pump. (
  • Do not start, stop, or change the dose of any drug without checking with your doctor. (
  • If you are a man and your sex partner gets pregnant while you take carmustine intracranial implant or within 3 months after your last dose, call your doctor right away. (
  • If you get pregnant while taking carmustine intracranial implant or within 6 months after your last dose, call your doctor right away. (
  • The new implant prototype provided a continuous drug dose high enough to shield against the virus for three months, Hanna said. (
  • Drug implants can be safe and effective for treating many conditions, and magnetically controlled implants are particularly interesting because you can adjust the dose after implantation by using different magnet strengths. (
  • Drug implants can be safe and effective for treating many conditions, and magnetically controlled implants are particularly interesting because you can adjust the dose after implantation by using different magnet strengths," said Ali Shademani , a PhD student in the biomedical engineering program at UBC. (
  • The implanted chip has dozens of sealed microreservoirs, each containing a concentrated dose of medicine. (
  • In-office use of a steroid-eluting implant for maintenance of frontal ostial patency after revision sinus surgery. (
  • As the plunger moves from the retracted position to the deployed position, it forces a medicament previously loaded into the injector body into the implant hollow and then pushes the implant out of the needle into the creature into which the needle has been inserted. (
  • The American Rhinologic Society endorses the utilization of drug-eluting implants into the sinus cavities. (
  • ADVANCE: a multi-site trial of bioabsorbable steroid-eluting sinus implants. (
  • RESOLVE: bioabsorbable steroid-eluting sinus implants for in-office treatment of recurrent sinonasal polyposis after sinus surgery: 6−month outcomes from a randomized, controlled, blinded study. (
  • Steroid-eluting sinus implant for in-office treatment of recurrent nasal polyposis: a prospective, multicenter study. (
  • ADVANCE II: A prospective, randomized study assessing safety and efficacy of bioabsorbable steroid-releasing sinus implants. (
  • Safety, feasibility, and efficacy of placement of steroid-eluting bioabsorbable sinus implants in the office setting: A prospective case series. (
  • Matheny K. Bioabsorbable steroid-releasing sinus implants in the frontal and maxillary sinuses: 2-year follow-up. (
  • Intersect ENT (NSDQ:XENT) launched its steroid-releasing sinus implant, Sinuva, in the U.S. today. (
  • This risk may be greater if you smoke, drink alcohol frequently, have a family history of osteoporosis , or use certain drugs such as seizure medications or steroids . (
  • This undated image provided by researcher Canan Dagdeviren in January shows an implant that can precisely drip medications deep into the brain by remote control. (
  • Scientists have created a hair-thin implant that can drip medications deep into the brain by remote control and with pinpoint precision. (
  • West Virginia retailers say drug dealers are having a tougher time getting their hands on over-the-counter medications containing pseudoephedrine. (
  • The implant can hold several different medications simultaneously, allowing complicated drug regimens to be followed with total accuracy. (
  • If 16 years of continued contraception wasn't cool enough, the implant can also be activated and deactivated wirelessly. (
  • As an example, when used as ocular implants in rats, a dexamethasone dimer implant is shown to effectively inhibit inflammation induced by lipopolysaccharide. (
  • The rising number of BIA-ALCL diagnoses prompted the need for additional study of the disease, as I discussed in my previous article, ' Breast Implant-Associated Lymphoma Diagnoses on the Rise . (
  • We will continue to monitor the medical literature concerning breast implants and this rare type of lymphoma, and report on new information as it becomes available. (
  • This rare T-cell lymphoma can develop as a result of breast implants, though the mechanism of injury is not fully understood at this time. (
  • As more information concerning the risks of BIA-ALCL becomes available, medical and regulatory agencies expect the number of these breast implant lymphoma diagnoses to continue to rise. (
  • If you--or someone you know--have been diagnosed with BIA-ALCL or some other lymphoma cancer as a result of breast implants, we encourage you to complete our free case evaluation . (
  • Do not breast-feed while you take carmustine intracranial implant. (
  • There are also famous people who have gotten their breast implants removed, like Crystal Hefner. (
  • Breast implant maker Allergan has issued a worldwide recall of its textured Biocell models, which. (
  • Two women have filed a class-action lawsuit against a major breast implant maker after hundreds of. (
  • The lawsuit comes after Allergan's Biocell breast implants were linked to a rare form of cancer. (
  • The FDA is asking surgeons to return their textured breast implants to Allergan, the manufacturer. (
  • Can Implants Cause Breast Cancer? (
  • It's been a controversial and emotional year for breast implant devices, and those who have received. (
  • SILVER SPRING, Md. - The safety of silicone breast implants has long been a subject of controversy, but a review by the Food and Drug Administration indicated another possible health risk. (
  • The agency is requesting reports of any confirmed cases of ALCL in women with breast implants and said it was working with manufacturers to update product labeling. (
  • You should not breast-feed while the implant is in place. (
  • Get the latest news about Breast Implants, Food And Drug Administration from the top newspapers and online news sites. (
  • The latest issue of Advanced Medical Technologies (AMDT) TechVision Opportunity Engine (TOE) profiles innovations that include the design of a low-energy implantable defibrillator, UV-based disinfection systems, a wearable orthopedic implant designing system, biomarker-detection of Alzheimer's, a deep learning system for breast cancer diagnosis, wearable cardiac monitoring devices, sticker-based vital signs monitoring devices, and drug-eluting stent for narrow blood vessels. (
  • In this particular study, the goal was to 'determine relative and absolute risks of breast-ALCL in women with breast implants. (
  • This information confirms previous theories that the textured surface of the breast implant provides a place for the bacteria to stick, and more surface area on the implant aids in the growth and proliferation of that bacteria. (
  • I]ncreased awareness [of BIA-ALCL] among the public, medical professionals, and regulatory bodies, promotion of alternative cosmetic procedures, and alertness to signs and symptoms of breast-ALCL in women with implants. (
  • A 20-year-old Panamanian woman was busted in Spain for trying to smuggle $6.6 million worth of cocaine in her breast implants. (
  • However, based on current data from the U.S. Food and Drug Administration (FDA), we do know that textured breast implants carry a greater risk of BIA-ALCL than smooth implants. (
  • Several lawsuits have already been filed this year on behalf of women who have been diagnosed with BIA-ALCL as a result of their breast implants. (
  • The Plaintiff had her 'Allergan Natrelle Silicone' breast implants for less than two years before her diagnosis. (
  • According to the Complaint , the 'Plaintiff maintains that Defendants' breast implants lacked proper warnings as to the dangers associated with their use. (
  • The lawsuit also alleges that the manufacturer of the breast implants failed to promptly and properly report the results of post-marketing studies that were required by the FDA. (
  • The Plaintiff in this case had the Mentor MemoryGel SILTEX breast implants for approximately eight years before her BIA-ALCL diagnosis. (
  • Pneumonitis caused by silicone gel following breast implant rupture. (
  • Although the FDA first identified a link between ALCL and breast implants in 2011, a lack of data restricted their statements to a call for more research into the connection. (
  • The surgeon laments the small data pool available for advancing the medical community's understanding of the condition and its association with breast implants, particularly the textured form of these devices. (
  • A breast implant is a prosthesis used to change the size, shape, and contour of a person's breast. (
  • Complications of implants may include breast pain, skin changes, infection, rupture, and a fluid collection around the breast. (
  • There are four general types of breast implants, defined by their filler material: saline solution, silicone gel, structured and composite filler. (
  • For the correction of male breast defects and deformities, the pectoral implant is the breast prosthesis used for the reconstruction and the aesthetic repair of a man's chest wall (see: gynecomastia and mastopexy). (
  • A mammoplasty procedure for the placement of breast implant devices has three purposes: primary reconstruction: the replacement of breast tissues damaged by trauma (blunt, penetrating, blast), disease (breast cancer), and failed anatomic development (tuberous breast deformity). (
  • In 2008, the longitudinal study Excess Mortality from Suicide and other External Causes of Death Among Women with Cosmetic Breast Implants (2007), reported that women who sought breast implants are almost 3 times as likely to commit suicide as are women who have not sought breast implants. (
  • Moreover, additional to the suicide-risk, women with breast implants also faced a trebled death-risk from alcoholism and the abuse of prescription and recreational drugs. (
  • In the future, it should be possible to manufacture therapeutic drugs that could be activated with light," said co-principal investigator Michael R Bruchas, associate professor of anesthesiology and neurobiology at Washington University. (
  • To tackle these sight-threatening diseases, a number of therapeutic methods have been investigated, ranging from topical eye drops to injections and implants. (
  • Associate Professor Robert Ali, Director of the Drug Alcohol Services Council in Adelaide, and his co-authors in research published in the Medical Journal of Australia, says that naltrexone is in theory an attractive treatment because it is inexpensive, long-acting, and generally well tolerated. (
  • A medical implant can include a bioerodible metal portion and a coating overlying the bioerodible metal portion. (
  • 2 . The medical implant of claim 1 , wherein the polyvalent metal cations of the coating are the same element as the polyvalent metal cations released by the bioerodible metal portion upon implantation. (
  • 3 . The medical implant of claim 1 , wherein polyvalent metal cations of the coating are selected from the group consisting of Mg 2+ , Zn 2+ , Ca 2+ , Ba 2+ , Fe 2+ , Fe 3+ , Al 3+ , Bi 4+ , and combinations thereof. (
  • 5 . The medical implant of claim 1 , wherein the polyvalent cations in the matrix have a valence of 3 or greater. (
  • 7 . The medical implant of claim 1 , wherein the polysaccharide comprises alginate. (
  • 8 . The medical implant of claim 1 , wherein the bioerodible metal portion comprises a metal selected from the group consisting of magnesium, iron, zinc, and alloys thereof. (
  • 9 . The medical implant of claim 1 , wherein the bioerodible metal portion comprises magnesium or an alloy thereof. (
  • 11 . The medical implant of claim 1 , wherein the bioerodible metal portion comprises MgO, FeCl 3 , or a combination thereof. (
  • 12 . The medical implant of claim 1 , wherein the medical implant is a stent. (
  • Cordis, a Cardinal Health company, and Medinol today announced that the first commercial cases using the EluNIR drug-eluting stent (DES) in the United States were performed at New York-Presbyterian Hospital/Columbia University Medical Center in New York City and the Piedmont Heart Institute in Atlanta. (
  • As with any medical implant, my mind readily races towards possible flaws and misuses of the Microchips technology. (
  • The Save Our Bones Bulletin: Implant That Builds Bone, Merck's New Drug Destroys Bone Density, Medical Establishment Retracts Deceptive Bisphosphonate Benefit, And More! (
  • Usnic acid was tested for its resistance to the pathogenic bacteria Staphylococcus aureus and Staphylococcus epidermidis , two common culprits for biofilm formation on medical implants. (
  • This blog chronicles legal and scientific news relating to personal injuries caused by defective drugs and medical devices. (
  • Justinian C. Lane is a personal injury attorney who focuses his practice on helping individuals injured by prescription drugs and medical devices. (
  • Published in 2009, medical researcher Joshua J. Jacobs wrote a report titled " Metal on Metal Bearing Surfaces ", that outlines some of the problems currently associated with hip implants. (
  • Disclosed are self-expanding medical implants for placement within a lumen of a patient. (
  • 2. The medical implant of claim 1, wherein said tubular structure comprises at least 32 strands. (
  • 15. The medical implant of claim 1, wherein said second conformal coating has a thickness up to 8 microns. (
  • Medical News Today has already reported on the use of 3D technology to make part of a sternum that surgeons successfully implanted into a cancer patient. (
  • Because of this, individuals who have suffered pain or hip implant revision surgery due to the Stryker ABG II are eligible to pursue compensation for their medical bills and other damages. (
  • The changes can even be made remotely by phone or computer, communicating with the implant over a secure radio band called the Medical Implant Communications Service. (
  • For the past 17 years, she has represented thousands of mass torts plaintiffs in both state and federal courts who have been injured by defective medical devices and drugs. (
  • The following drug information is obtained from various newswires, published medical journal articles, and medical conference presentations. (
  • Like previous studies on BIA-ALCL, this article found that textured implants are associated with BIA-ALCL, while smooth implants do not appear to be. (
  • Prospective, Randomized, Controlled Arm Study Comparing the Coverage of the Zotarolimus-eluting Stent vs Bare Metal Stent Implanted in ST- Elevation Myocardial Infarction (STEMI). (

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