Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
SURFACE-ACTIVE AGENTS that induce a dispersion of undissolved material throughout a liquid.
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.
The branch of medicine concerned with the application of NANOTECHNOLOGY to the prevention and treatment of disease. It involves the monitoring, repair, construction, and control of human biological systems at the molecular level, using engineered nanodevices and NANOSTRUCTURES. (From Freitas Jr., Nanomedicine, vol 1, 1999).
Relating to the size of solids.
Nanometer-sized, hollow, spherically-shaped objects that can be utilized to encapsulate small amounts of pharmaceuticals, enzymes, or other catalysts (Glossary of Biotechnology and Nanobiotechnology, 4th ed).
Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
A biocompatible polymer used as a surgical suture material.
The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
The application of suitable drug dosage forms to the skin for either local or systemic effects.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.
Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)
A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
Uptake of substances through the SKIN.
The adaptation of drug administration to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.
Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.
The chemical and physical integrity of a pharmaceutical product.
Tailored macromolecules harboring covalently-bound biologically active modules that target specific tissues and cells. The active modules or functional groups can include drugs, prodrugs, antibodies, and oligonucleotides, which can act synergistically and be multitargeting.
Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)
Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer.
Application of pharmaceutically active agents on the tissues of the EYE.
Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.
Hard or soft soluble containers used for the oral administration of medicine.
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
Tree-like, highly branched, polymeric compounds. They grow three-dimensionally by the addition of shells of branched molecules to a central core. The overall globular shape and presence of cavities gives potential as drug carriers and CONTRAST AGENTS.
Spherical particles of nanometer dimensions.
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
A polyester used for absorbable sutures & surgical mesh, especially in ophthalmic surgery. 2-Hydroxy-propanoic acid polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with 1,4-dioxane-2,5-dione copolymer of molecular weight about 80,000 daltons.
Substances that cause the adherence of two surfaces. They include glues (properly collagen-derived adhesives), mucilages, sticky pastes, gums, resins, or latex.
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
Characteristics or attributes of the outer boundaries of objects, including molecules.
Delivery of the FETUS and PLACENTA under the care of an obstetrician or a health worker. Obstetric deliveries may involve physical, psychological, medical, or surgical interventions.
The giving of drugs, chemicals, or other substances by mouth.
Strongly cationic polymer that binds to certain proteins; used as a marker in immunology, to precipitate and purify enzymes and lipids. Synonyms: aziridine polymer; Epamine; Epomine; ethylenimine polymer; Montrek; PEI; Polymin(e).
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.
Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
Dynamic and kinetic mechanisms of exogenous chemical and DRUG LIBERATION; ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and DRUG TOXICITY as a function of dosage, and rate of METABOLISM. LADMER, ADME and ADMET are abbreviations for liberation, absorption, distribution, metabolism, elimination, and toxicology.
Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Manufacturing technology for making microscopic devices in the micrometer range (typically 1-100 micrometers), such as integrated circuits or MEMS. The process usually involves replication and parallel fabrication of hundreds or millions of identical structures using various thin film deposition techniques and carried out in environmentally-controlled clean rooms.
An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
A cell line derived from cultured tumor cells.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Synthesized magnetic particles under 100 nanometers possessing many biomedical applications including DRUG DELIVERY SYSTEMS and CONTRAST AGENTS. The particles are usually coated with a variety of polymeric compounds.
Nanometer-sized tubes composed mainly of CARBON. Such nanotubes are used as probes for high-resolution structural and chemical imaging of biomolecules with ATOMIC FORCE MICROSCOPY.
A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.
The application of high intensity ultrasound to liquids.
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
A network of cross-linked hydrophilic macromolecules used in biomedical applications.
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
Polysaccharide gums from PLANTS.
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.
Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.
A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986)
Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.
Submicron-sized fibers with diameters typically between 50 and 500 nanometers. The very small dimension of these fibers can generate a high surface area to volume ratio, which makes them potential candidates for various biomedical and other applications.
Nanometer-scale composite structures composed of organic molecules intimately incorporated with inorganic molecules. (Glossary of Biotechnology and Nanobiotechology Terms, 4th ed)
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.
A property of the surface of an object that makes it stick to another surface.
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.
Technique whereby the weight of a sample can be followed over a period of time while its temperature is being changed (usually increased at a constant rate).
Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.
Method of using a polycrystalline powder and Rietveld refinement (LEAST SQUARES ANALYSIS) of X-RAY DIFFRACTION or NEUTRON DIFFRACTION. It circumvents the difficulties of producing single large crystals.
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
Regular insulin preparations that contain the SUS SCROFA insulin peptide sequence.
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.
A polyhedral CARBON structure composed of around 60-80 carbon atoms in pentagon and hexagon configuration. They are named after Buckminster Fuller because of structural resemblance to geodesic domes. Fullerenes can be made in high temperature such as arc discharge in an inert atmosphere.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
The concept concerned with all aspects of providing and distributing health services to a patient population.
The thermodynamic interaction between a substance and WATER.
Polymerized forms of styrene used as a biocompatible material, especially in dentistry. They are thermoplastic and are used as insulators, for injection molding and casting, as sheets, plates, rods, rigid forms and beads.
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
A subfield of acoustics dealing in the radio frequency range higher than acoustic SOUND waves (approximately above 20 kilohertz). Ultrasonic radiation is used therapeutically (DIATHERMY and ULTRASONIC THERAPY) to generate HEAT and to selectively destroy tissues. It is also used in diagnostics, for example, ULTRASONOGRAPHY; ECHOENCEPHALOGRAPHY; and ECHOCARDIOGRAPHY, to visually display echoes received from irradiated tissues.
The insertion of drugs into the vagina to treat local infections, neoplasms, or to induce labor. The dosage forms may include medicated pessaries, irrigation fluids, and suppositories.
A salt produced by the reaction of zinc oxide with acetic acid and used as an astringent, styptic, and emetic.
A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.
An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.
Acrylic acids or acrylates which are substituted in the C-2 position with a methyl group.
Methods of creating machines and devices.
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Small encapsulated gas bubbles (diameters of micrometers) that can be used as CONTRAST MEDIA, and in other diagnostic and therapeutic applications. Upon exposure to sufficiently intense ultrasound, microbubbles will cavitate, rupture, disappear, release gas content. Such characteristics of the microbubbles can be used to enhance diagnostic tests, dissolve blood clots, and deliver drugs or genes for therapy.
Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Introduction of substances into the body using a needle and syringe.
The contribution to barometric PRESSURE of gaseous substance in equilibrium with its solid or liquid phase.
A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.
Devices used in a technique by which cells or tissues are grown in vitro or, by implantation, in vivo within chambers permeable to diffusion of solutes across the chamber walls. The chambers are used for studies of drug effects, osmotic responses, cytogenic and immunologic phenomena, metabolism, etc., and include tissue cages.
Devices that cause a liquid or solid to be converted into an aerosol (spray) or a vapor. It is used in drug administration by inhalation, humidification of ambient air, and in certain analytical instruments.
A health care system which combines physicians, hospitals, and other medical services with a health plan to provide the complete spectrum of medical care for its customers. In a fully integrated system, the three key elements - physicians, hospital, and health plan membership - are in balance in terms of matching medical resources with the needs of purchasers and patients. (Coddington et al., Integrated Health Care: Reorganizing the Physician, Hospital and Health Plan Relationship, 1994, p7)
Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.
The generic term for salts derived from silica or the silicic acids. They contain silicon, oxygen, and one or more metals, and may contain hydrogen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th Ed)
The study of the deformation and flow of matter, usually liquids or fluids, and of the plastic flow of solids. The concept covers consistency, dilatancy, liquefaction, resistance to flow, shearing, thixotrophy, and VISCOSITY.
A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Persistent pain that is refractory to some or all forms of treatment.
Generally refers to the digestive structures stretching from the MOUTH to ANUS, but does not include the accessory glandular organs (LIVER; BILIARY TRACT; PANCREAS).
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
Elements of limited time intervals, contributing to particular results or situations.
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.
A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
Chemical reaction in which monomeric components are combined to form POLYMERS (e.g., POLYMETHYLMETHACRYLATE).
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Uptake of substances through the lining of the INTESTINES.
Polysaccharides composed of repeating galactose units. They can consist of branched or unbranched chains in any linkages.
Sharp instruments used for puncturing or suturing.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Peptides that have the ability to enter cells by crossing the plasma membrane directly, or through uptake by the endocytotic pathway.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Peptides composed of between two and twelve amino acids.
A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
The rate dynamics in chemical or physical systems.
Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Transmission of energy or mass by a medium involving movement of the medium itself. The circulatory movement that occurs in a fluid at a nonuniform temperature owing to the variation of its density and the action of gravity. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed; Webster, 10th ed)
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Injections made into a vein for therapeutic or experimental purposes.
Extraction of the FETUS by means of abdominal HYSTEROTOMY.
Use of ultrasound to increase the percutaneous adsorption of drugs.
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
A peptide which is a homopolymer of lysine.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
The relationship between the dose of an administered drug and the response of the organism to the drug.
An estrogen responsive cell line derived from a patient with metastatic human breast ADENOCARCINOMA (at the Michigan Cancer Foundation.)
Complex compounds in which a dumbbell shaped molecule is encircled by a macrocycle. They are named after rota (wheel) and axis (axle). Notation with a prefix is used to indicate the number of interlocked components. They have potential use in NANOTECHNOLOGY. Rotaxanes have been made with CYCLODEXTRINS and CYCLIC ETHERS.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.

Transdermal photopolymerization for minimally invasive implantation. (1/6144)

Photopolymerizations are widely used in medicine to create polymer networks for use in applications such as bone restorations and coatings for artificial implants. These photopolymerizations occur by directly exposing materials to light in "open" environments such as the oral cavity or during invasive procedures such as surgery. We hypothesized that light, which penetrates tissue including skin, could cause a photopolymerization indirectly. Liquid materials then could be injected s.c. and solidified by exposing the exterior surface of the skin to light. To test this hypothesis, the penetration of UVA and visible light through skin was studied. Modeling predicted the feasibility of transdermal polymerization with only 2 min of light exposure required to photopolymerize an implant underneath human skin. To establish the validity of these modeling studies, transdermal photopolymerization first was applied to tissue engineering by using "injectable" cartilage as a model system. Polymer/chondrocyte constructs were injected s.c. and transdermally photopolymerized. Implants harvested at 2, 4, and 7 weeks demonstrated collagen and proteoglycan production and histology with tissue structure comparable to native neocartilage. To further examine this phenomenon and test the applicability of transdermal photopolymerization for drug release devices, albumin, a model protein, was released for 1 week from photopolymerized hydrogels. With further study, transdermal photpolymerization potentially could be used to create a variety of new, minimally invasive surgical procedures in applications ranging from plastic and orthopedic surgery to tissue engineering and drug delivery.  (+info)

Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. (2/6144)

Cancer therapies using genes and other macromolecules might realize their full clinical potential if they could be delivered to tumor tissue in optimal quantities. Unfortunately, the compromised circulation within tumors poses a formidable resistance to adequate and uniform penetration of these agents. Previously, we have proposed elevated interstitial fluid pressure (IFP) as a major physiological barrier to delivery of macromolecules. Here we postulate that modulation of tumor microvascular pressure (MVP) and associated changes in IFP would enhance macromolecular delivery into a solid tumor. To test our hypothesis, we altered tumor MVP by either periodic injection or continuous infusion of angiotensin II (AII) and measured the resulting changes in IFP and uptake of macromolecules. We used the nicotinyl hydrazine derivative of human polyclonal IgG (HYNIC-IgG) as a nonspecific macromolecule and CC49 antibody as a specific macromolecule. We found that both chronic and periodic modulation of tumor MVP enhances transvascular fluid filtration, leading to a 40% increase in total uptake of the specific antibody within 4 hr of its administration. Conversely, neither continuous nor periodic infusion of AII induced any increase in uptake of nonspecific antibodies. Strategies to improve delivery of macromolecules and limitations of this approach are identified.  (+info)

Oxidized low-density lipoprotein as a delivery system for photosensitizers: implications for photodynamic therapy of atherosclerosis. (3/6144)

Photodynamic therapy is a promising new strategy in the treatment of cardiovascular diseases. Photodynamic therapy for vascular diseases may be improved by the specific delivery of photosensitizers to the atherosclerotic lesion. In this study, we studied whether oxidatively modified low-density lipoprotein (OxLDL) could be used as a specific carrier for photosensitizers, thereby using the scavenger receptor expressed on macrophages as a target. The photosensitizer aluminum phthalocyanine chloride (AlPc) was incorporated into OxLDL, and its photodynamic effects were studied. Macrophages (RAW 264.7) were incubated with various concentrations of OxLDL-AlPc for different periods. After illumination of the cells with red light, cytotoxicity was observed that was dependent on the time of illumination and incubation. Macrophages incubated with OxLDL-AlPc that were not illuminated revealed no cytotoxicity. The uptake of the OxLDL-AlPc complexes was mediated by scavenger receptors expressed on macrophages. In the presence of the polyanion polyinosinic acid, a specific ligand for scavenger receptors, no cytotoxicity could be observed. Serum incubations of the OxLDL-AlPc complexes revealed that these complexes stay intact after incubation. No redistribution of AlPc to other plasma (lipo-) proteins could be detected, and 80-90% of the AlPc remained associated with the OxLDL particle. These results indicate that OxLDL may function as a specific delivery system for photosensitizers to the scavenger receptors expressed on the macrophages in the atherosclerotic lesion, increasing the beneficial effects of photodynamic therapy for cardiovascular diseases.  (+info)

Early use of inhaled nedocromil sodium in children following an acute episode of asthma. (4/6144)

BACKGROUND: Current guidelines on the treatment of childhood asthma recommend the introduction of an anti-inflammatory drug in children who have persistent symptoms and require regular treatment with a bronchodilator. The efficacy and safety of inhaled nedocromil sodium (Tilade Mint aerosol) administered using a Fisonair spacer at a dose of 4 mg three times daily was compared with placebo in the treatment of asthmatic children aged 6-12 years who are symptomatic and recovering from an acute exacerbation of asthma. METHODS: A group comparative, double blind, placebo controlled trial was performed in children who were recovering from an acute episode of asthma following treatment in the emergency department of the hospital or in children referred from their general practitioner following a wheezing episode and documented evidence of at least two previous episodes of wheezing. A two week baseline period on existing bronchodilator treatment was followed by a 12 week treatment period on either nedocromil sodium (2 mg/puff) or placebo. Both treatments were administered using a Fisonair spacer at a dose of two puffs three times daily. Changes from baseline values in daytime asthma and night time asthma symptom scores, usage of rescue bronchodilators, mean peak expiratory flow (PEF) recorded twice daily on diary cards, patients' opinion of treatment, and withdrawals due to treatment failure were measured during the primary treatment period (last six weeks of treatment). RESULTS: One hundred and forty two children aged 6-12 years entered the baseline period. Sixty three were withdrawn due to failure to meet the entry criteria (18) or the criteria for asthma symptom severity (15) or reversibility (9), because they developed uncontrolled asthma (2), because they took disallowed treatment (2), or for other non-trial related reasons (17). Seventy nine patients (46 boys) of mean age 8. 8 years entered the treatment period. There were significant differences in the changes from baseline values during the last six weeks of treatment in favour of nedocromil sodium compared with placebo in the primary variables of daytime asthma and night time asthma, morning and evening PEF, and the usage of rescue inhaled bronchodilators; 53% of patients reported nedocromil sodium to be very or moderately effective compared with 44% placebo. Improvement in asthma symptoms, PEF, and reduction in use of rescue bronchodilators did not reach statistical significance until after six weeks of treatment. Twenty two patients were withdrawn or dropped out during the treatment phase, 12 due to uncontrolled asthma or persistence of asthma symptoms, four due to suspected adverse drug reactions (nedocromil sodium 3 (headaches 2, angio-oedema/urticaria 1), placebo 1(persistent cough)), and six due to non-treatment related reasons. Seventy one adverse events were reported by 27 patients in the nedocromil group and 75 by 30 patients in the placebo group. CONCLUSIONS: Asthma symptoms, use of bronchodilators, and lung function can be improved significantly in children recovering from an acute exacerbation of asthma or wheeze and currently receiving treatment with bronchodilators alone by the addition of inhaled nedocromil sodium at a dose of 4 mg three times daily administered using a Fisonair holding chamber.  (+info)

Photochemical internalization: a novel technology for delivery of macromolecules into cytosol. (5/6144)

The therapeutic usefulness of macromolecules, such as in gene therapy, is often limited by an inefficient transfer of the macromolecule to the cytosol and a lack of tissue-specific targeting. The possibility of photochemically releasing macromolecules from endosomes and lysosomes into the cytosol was examined. Endocytosed macromolecules and photosensitizer were exposed to light and intracellular localization and the expression of macomolecules in the cytosol was analyzed. This novel technology, named photochemical internalization (PCI), was found to efficiently deliver type I ribosome-inactivating proteins, horseradish peroxidase, a p21ras-derived peptide, and a plasmid encoding green fluorescent protein into cytosol in a light-dependent manner. The results presented here show that PCI can induce efficient light-directed delivery of macromolecules into the cytosol, indicating that PCI may have a variety of useful applications for site-specific drug delivery, e.g., in gene therapy, vaccination, and cancer treatment.  (+info)

Nucleotide exchange in genomic DNA of rat hepatocytes using RNA/DNA oligonucleotides. Targeted delivery of liposomes and polyethyleneimine to the asialoglycoprotein receptor. (6/6144)

Chimeric RNA/DNA oligonucleotides have been shown to promote single nucleotide exchange in genomic DNA. A chimeric molecule was designed to introduce an A to C nucleotide conversion at the Ser365 position of the rat factor IX gene. The oligonucleotides were encapsulated in positive, neutral, and negatively charged liposomes containing galactocerebroside or complexed with lactosylated polyethyleneimine. The formulations were evaluated for stability and efficiency in targeting hepatocytes via the asialoglycoprotein receptor. Physical characterization and electron microscopy revealed that the oligonucleotides were efficiently encapsulated within the liposomes, with the positive and negative formulations remaining stable for at least 1 month. Transfection efficiencies in isolated rat hepatocytes approached 100% with each of the formulations. However, the negative liposomes and 25-kDa lactosylated polyethyleneimine provided the most intense nuclear fluorescence with the fluorescein-labeled oligonucleotides. The lactosylated polyethyleneimine and the three different liposomal formulations resulted in A to C conversion efficiencies of 19-24%. In addition, lactosylated polyethyleneimine was also highly effective in transfecting plasmid DNA into isolated hepatocytes. The results suggest that both the liposomal and polyethyleneimine formulations are simple to prepare and stable and give reliable, reproducible results. They provide efficient delivery systems to hepatocytes for the introduction or repair of genetic mutations by the chimeric RNA/DNA oligonucleotides.  (+info)

Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. (7/6144)

Poly(ethylenimine) (PEI) is one of a number of polycations that has been used successfully to transfer genes into living cells. Although PEI shows promise in the field of gene therapy, to date no rigorous proof of mechanism has been published regarding the fate of PEI/DNA administered for transfection. Here we show, by using fluorescent labeling and confocal microscopy, the paths of PEI/DNA complexes from endocytosis to gene expression. We found that complexes attach to cell surfaces and migrate into clumps that are endocytosed. The endocytotic vesicles grow in number and size and are occasionally seen to lyse. Most interesting is the fact that endocytosed PEI, whether administered with or without DNA, undergoes nuclear localization in the form of ordered structures.  (+info)

Intranuclear delivery of an antiviral peptide mediated by the B subunit of Escherichia coli heat-labile enterotoxin. (8/6144)

We report an intracellular peptide delivery system capable of targeting specific cellular compartments. In the model system we constructed a chimeric protein consisting of the nontoxic B subunit of Escherichia coli heat-labile enterotoxin (EtxB) fused to a 27-mer peptide derived from the DNA polymerase of herpes simplex virus 1. Viral DNA synthesis takes places in the nucleus and requires the interaction with an accessory factor, UL42, encoded by the virus. The peptide, designated Pol, is able to dissociate this interaction. The chimeric protein, EtxB-Pol, retained the functional properties of both EtxB and peptide components and was shown to inhibit viral DNA polymerase activity in vitro via disruption of the polymerase-UL42 complex. When added to virally infected cells, EtxB-Pol had no effect on adenovirus replication but specifically interfered with herpes simplex virus 1 replication. Further studies showed that the antiviral peptide localized in the nucleus, whereas the EtxB component remained associated with vesicular compartments. The results indicate that the chimeric protein entered through endosomal acidic compartments and that the Pol peptide was cleaved from the chimeric protein before being translocated into the nucleus. The system we describe is suitable for delivery of peptides that specifically disrupt protein-protein interactions and may be developed to target specific cellular compartments.  (+info)

The Report Ocular Drug Delivery Technology Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2017 - 2025 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - This report on the Global Ocular Drug Delivery Technology market analyzes the current and future scenario of the global market. Rise in private and public funding for R&D of novel drug delivery technologies, increase in prevalence of macular degeneration & diabetic retinopathy, and favorable regulatory scenario for introduction of innovative technologies are boosting the growth of the Global Ocular Drug Delivery Technology market. Rising demand for targeted drug delivery to the affected ocular tissue, and elimination of drug due to nasolacrimal drainage system when administered via topical route are some of the factors expected to drive the growth of Global Ocular Drug Delivery Technology market during the forecast ...
Plants are natures remedies and have been used by human beings on earth since ancient times for food and medicine. Today there are global movements towards finding of herbal medicaments in plants to bring them in market via a suitable drug delivery system for mankind. The basic thought behind it is treatment of each disease is hidden in nature. However, delivery of herbal drugs also requires modification with the purpose to achieve sustain release, to increase patient compliance etc. previously herbal drugs could not attract scientists towards the modifications of novel drug delivery systems due to processing, standardizing, extracting and identification difficulties. But now days with the advancement in the technology, novel drug delivery systems (NDDS) open the door towards the development of herbal novel drug delivery system. With use of advance techniques protection from toxicity, enhancement in stability, improved bioavailability of herbal formulations, protection from physical and ...
The Center for Business Intelligence (CBI) Summit on Novel Drug Delivery Strategies will convene industry leaders in the drug delivery, business development, lifecycle management and the commercialization arena to discuss the growing drug delivery market. The conference will examine the effects of incorporating a novel drug delivery system into the product lifecycle in early stages of development by assessing markets prior to commercialization.. Novel drug delivery systems are brought to the market through strategic alliances between pharmaceutical, biotech and drug delivery companies. Licensing agreements are an integral part of that process and their complexity varies with the value of the technology and the stage of development it is introduced. On Day 1 of the conference, Foley & Lardner LLP Associate Michael Yamauchi will lead the session, Analyzing Licensing Agreement Strategies through Interactive Mock Case Study Discussions. This executive exchange facilitates open discussion on key ...
Further in the Controlled-Release Drug Delivery Technology Market research report, following points are included along with in-depth study of each point:. • Production Analysis- Production of the Controlled-Release Drug Delivery Technology is analysed with respect to different regions, types and applications. Here, price analysis of various Controlled-Release Drug Delivery Technology Market key players is also covered.. • Sales and Revenue Analysis- Both, sales and revenue are studied for the different regions of the global Controlled-Release Drug Delivery Technology Market. another major aspect, price, which plays important part in the revenue generation is also assessed in this section for the various regions.. • Supply and Consumption- In continuation with sales, this section studies supply and consumption for the Controlled-Release Drug Delivery Technology Market. This part also sheds light on the gap between supple and consumption. Import and export figures are also given in this ...
Market experts suggest that, There is a continuous growth in the market of drug delivery systems and will continue to grow at an impressive rate in future also. The novel drug delivery technologies enable to formulate the novel drug delivery devices by incorporating the drug molecules into new delivery systems, thus providing numerous therapeutic and commercial advantages. It was observed that NDDS market was segmented on the basis of route of administration, type of carrier and geographical region. In route of administration segment, injectable drug delivery system was observed as the largest market in 2015 followed by oral drug delivery system. Injectable drug delivery system comprises of several benefits over other dosage forms in cases such as unconsciousness, nausea, in emergency clinical episodes. The injectable administration route is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. On the basis ...
Michael J. Rathbone This two volume Second Edition of Modified-Release Drug Delivery Technology describes the anatomical, physiological, pharmaceutical, and technological aspects of oral, colonic and rectal, ocular, oral mucosal, dermal and transdermal, nasal, vaginal, and pulmonary delivery routes.. Modified-Release Drug Delivery Technology provides insight and critical assessment of the many available and emerging modified release drug delivery systems for their current and future value.. Modified-Release Drug Delivery Technology is available as a 2-volume set or each volume may be purchased individually.. Contents and information on Volume One ...
A team of UC Davis scientists has shown in experimental mouse models that a new drug delivery system allows for administration of three times the maximum tolerated dose of a standard drug therapy for advanced bladder cancer, ...
Scientists in Syracuse Universitys Chemistry Department have created a new drug delivery system expected to advance the effectiveness of cancer-killing drugs. It uses gold nanoparticles with attached DNA that binds to a proven anti-cancer drug, Doxorubicin or DOX.
Novel drug delivery systems are now a days is creating a new interest in development of drug deliveries. Vesicular drug delivery system is also a part of these novel drug delivery systems. TDDS is the permeability of the skin, it is permeable to small molecules, lipophilic drug and highly impermeable to the macromolecules and hydrophilic drugs. Recent approaches have resulted in design of two vesicular carriers, ethosomes and ultra flexible lipid based elastic vesicles, transferosomes. Transferosomes have recently been introduced, which are capable of transdermal delivery of low as well as high molecular weight drugs. This offers several potential advantages over conventional routes like avoidance of first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half life drugs, improving physiological and pharmacological response and have been applied to increases the efficiency of the material transfer across the intact skin, by the use of
Summary. Latest report, Global Drug Delivery Technologies - Innovation Driven by Rapidly Expanding Injectables Market and Increasing Usage of Complex Biologics during the Forecast Period discusses the drug delivery technologies and trends in the market and the evolving business strategies being adopted and leveraged by companies globally.. The ultimate goal of drug delivery research is to develop formulations and devices that can be used in clinical applications to treat various diseases. Delivering a drug with the desired release kinetics requires an understanding of the underlying physicochemical properties of the drug, which determine the type of delivery material and drug release mechanism.. Numerous parameters need to be considered, and their inter-dependence has to be taken into account to develop successful drug delivery systems for the intended applications. It is important to understand the complexity associated with the development of a drug delivery system that can ultimately be ...
TY - JOUR. T1 - Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer. AU - Cheng, Yu. AU - Samia, Anna C.. AU - Meyers, Joseph D.. AU - Panagopoulos, Irene. AU - Fei, Baowei. AU - Burda, Clemens. PY - 2008/8/13. Y1 - 2008/8/13. N2 - A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible cage that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.. AB - A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was ...
The global novel drug delivery systems (NDDS) in cancer therapy market size was valued at USD 4.31 billion in 2016 and is projected to grow at a CAGR of 22.9% during the forecast period. Worldwide increasing incidence of cancer, availability of research funding, increase in awareness about alternative methods for treatment, and favorable reimbursement scenarios in developed nations are some of the key drivers of this market.
World Congress on Pharmaceutics & Novel Drug Delivery Systems on Jun 15, 2020 in Zurich, Switzerland at Zurich, Switzerland. Ology Mavens is hosting...
Novel Drug Delivery Systems Market Was Valued At USD 165.4 Bn In 2015, And Is Expected To Reach USD 202.5 Bn By 2022, Expanding At A CAGR Of 2.7% From 2016 To 2022 Drug delivery technologies alter the release of drug so as to facilitate optimum efficacy and safety.Such technologies simplify the dosing regimen and reduce side-effects, thus boosting patient compliance. The global drug delivery market is divided into nine segments, namely, oral, pulmonary, transdermal, injectable, ocular, nasal, topical, implantable,andtransmucosal. Drug delivery technologies have grown phenomenally from plain drug reformulation and release technologies to innovative platforms that hold a huge potential for the effective delivery of biologicals and novel drugs.. The major drivers of this market are patent expiries of certain blockbuster drugs, growing demand for self administration and home healthcare devices, rising incidence of chronic diseases such as cardiovascular diseases, diabetes and cancer, growing focus on pediatric and geriatric patients, and advancing technology.However, ...
TY - JOUR. T1 - Standpoint on the priority of TNTs and CNTs as targeted drug delivery systems. AU - Ranjous, Yasmin. AU - Regdon, Géza. AU - Pintye-Hódi, K.. AU - Sovány, Tamás. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Conventional drug delivery systems have limitations according to their toxicity and poor solubility, bioavailability, stability, and pharmacokinetics (PK). Here, we highlight the importance of functionalized titanate nanotubes (TNTs) as targeted drug delivery systems. We discuss the differences in the physicochemical properties of TNTs and carbon nanotubes (CNTs) and focus on the use of functionalization to improve their characteristics. TNTs are promising materials for drug delivery systems because of their superb properties compared with CNTs, such as their processability, wettability, and biocompatibility. Functionalization improves nanoparticles (NPs) via their surface modification and enables them to achieve the targeted therapy.. AB - Conventional drug delivery systems have ...
Niosomes are non-ionic surfactant based liposomes. Niosomes, the novel drug delivery system are self assembled vesicles primarily of synthetic surfactant incorporated with cholesterol as an excipient. They are the vesicles formed by hydrating the cholesterol and non-ionic surfactant. The main aim of niosome includes use of drug in efficient manner which includes reduced dose, reduced side effect, reduced dosage frequency, greater patient compliance and maximum concentration at the site of action so, that under exposure to the entire body. It includes higher therapeutic efficiency and reduced side effect. Niosomes are thought to be the better candidates drug delivery system due to the various factor like cost, stability, etc. various types of drug delivery is possible using niosomes like targetting drug action, ophthalmic, topical, parenteral, etc. Drug delivery potential of niosomes can be enhanced by using novel concept like proniosomes, discomes and aspasomes. Niosomes serves better aid in ...
DUBLIN, May 21, 2021 /PRNewswire/ -- The Cardiovascular Drug Delivery - Technologies, Markets & Companies report from Jain PharmaBiotech has been added to ResearchAndMarkets.coms offering. The cardiovascular drug delivery markets are estimated for the years 2018 to 2028 on the basis of epidemiology and total markets for cardiovascular therapeutics.. The estimates take into consideration the anticipated advances and availability of various technologies, particularly drug delivery devices in the future. Markets for drug-eluting stents are calculated separately. The role of drug delivery in developing cardiovascular markets is defined and unmet needs in cardiovascular drug delivery technologies are identified.. Drug delivery to the cardiovascular system is approached at three levels: (1) routes of drug delivery; (2) formulations; and finally (3) applications to various diseases.. Formulations for drug delivery to the cardiovascular system range from controlled release preparations to delivery of ...
The promise of drug delivery strategies is in their potential to improve current treatments and create opportunities for experimental therapy. Drugs that ...
ABSTRACT. Development of new drug delivery system has become the requirement of todays pharmaceutical industry. As the number of off-patent drugs and cost of new drug development increases, pharmaceutical companies are managing the life cycles of their products (from product launch to their withdrawal from the market) by adopting new and innovative delivery systems. This gives the pharmaceutical industry another chance to make the most of their current products. Oral route is the most preferred route for administration of drugs as the administration is easy and economic. But the problem is the loss of their functions due to the short residence in the body. About 80% of the administered drugs are excreted without being absorbed. This article comprehensively explains need of hydrogels and its modifications to prolong the residence time of drugs in the body, with brief introduction of associated other drug delivery systems.. Keywords: Superporous Hydrogels, Absorption Window, Stomach Specific Drug ...
drug delivery system for sale - 107901 - drug delivery system wholesalers & drug delivery system manufacturers from China manufacturers.
Adult neural stem cells to develop a new stem cell-based drug delivery therapy that may ultimately help treat a variety of inherited genetic disorders like Hunter syndrome.
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Wim Jiskoot graduated as a pharmacist in 1987 and received his PhD degree in 1991 at Utrecht University on pharmaceutical aspects of monoclonal antibodies. As a postdoctoral fellow at the University of Utah (1991-1993) he studied protein-ligand interactions using biophysical techniques. From 1994-1998 he was head of the Department of Bacterial Vaccine Development at the National Institute of Public Health and the Environment (RIVM), Bilthoven. In 1998 he became a staff member at the Department of Pharmaceutics, Utrecht University, where he focused his research on formulation and physicochemical characterization of therapeutic proteins and vaccines. In March 2006 he was appointed as full professor at the Division of Drug Delivery Technology, LACDR, and as the coordinator of the Biologics Research Platform Leiden (BRPL). His current research is concentrated on two themes: (1) formulation and unwanted immunogenicity of therapeutic proteins and (2) vaccine delivery.. ...
Wim Jiskoot graduated as a pharmacist in 1987 and received his PhD degree in 1991 at Utrecht University on pharmaceutical aspects of monoclonal antibodies. As a postdoctoral fellow at the University of Utah (1991-1993) he studied protein-ligand interactions using biophysical techniques. From 1994-1998 he was head of the Department of Bacterial Vaccine Development at the National Institute of Public Health and the Environment (RIVM), Bilthoven. In 1998 he became a staff member at the Department of Pharmaceutics, Utrecht University, where he focused his research on formulation and physicochemical characterization of therapeutic proteins and vaccines. In March 2006 he was appointed as full professor at the Division of Drug Delivery Technology, LACDR, and as the coordinator of the Biologics Research Platform Leiden (BRPL). His current research is concentrated on two themes: (1) formulation and unwanted immunogenicity of therapeutic proteins and (2) vaccine delivery.. ...
MUNICH, Germany, June 6, 2017 - Brainlab and Medicenna Therapeutics Corp (the Company or Medicenna; TSXV MDNA) jointly announced today that recurrent Glioblastoma (rGB) patients in a Phase 2b clinical trial of MDNA55, a targeted immunotherapy agent, have been treated at three clinical centers in the United States using innovative drug delivery technology from Brainlab. The investigators used convection enhanced delivery (CED) to inject MDNA55, together with an imaging agent, directly into the tumor. When combined with real-time image guided MRI, CED allows delivery of MDNA55 at high concentrations into the tumor tissue while avoiding exposure to the rest of the body. The current Phase 2b clinical trial plans to enroll 43 adult patients with rGB at leading brain cancer centers in the United States.. Precise targeting is an integral part in the treatment of brain tumors to achieve significant coverage. iPlan® Flow planning software from Brainlab helps determine trajectories for drug ...
Adherence is crucial in medical glaucoma therapy, although half of the patients skip eyedrops. In recent years alternative drug-delivery systems have been developed. One of the most promising seems the contact lens (CL). This systematic review aims to present the in vivo efficacy of different CL drug-delivery systems. A total of 126 studies were identified following a literature search adhering to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. After full-text evaluation, 19 studies about CL drug-delivery systems were included. To date, the following drug-delivery systems have been investigated in vivo: drug-soaked CL, CL with physical barriers (vitamin E), molecularly imprinted CL, CL with implants, and nanoparticle-loaded CL. Nanoparticle-loaded CL and CL with implants seem the most promising drug-delivery systems, although initial burst drug release and patient acceptance may limit their widespread use in current practice. Clinical trials are warranted to
New drug delivery methods have potential to improve compliance through ease of use, but have brought up some new questions. Is reconfiguring an injected insulin into an inhaled version, for example, just a way to relaunch a product, or does the invention provide more than a me-too product? adds a report on 2016 Global Drug Delivery Technologies Market Status, 2011-2022 Market Historical and Forecasts, Professional Market Research Report. This research study is segmented on the bases of applications, technology and geography.
London (PRWEB) October 29, 2013 -- Report Details Drug delivery technology - discover technological and commercial prospects What does the future hold for
Research and Markets has announced the addition of the "Global Drug Delivery Technologies - Innovation Driven by Rapidly Expanding Injectables Ma
Global Nasal Drug Delivery Technologies Market key players are Merck & Co., Inc., Novartis AG, J & J, Pfizer Inc., AstraZeneca, AptarGroup and others.
The global nasal drug delivery technology market is projected to reach USD 64.20 billion by 2021 from USD 44.00 billion in 2016, at a CAGR of 6.5%
A dispense interface for use with a drug delivery device. The dispense interface comprises a main outer body and an inner body. The inner body may be configured for connection to a drug delivery device and defines a first reservoir and a second reservoir. A first piercing needle is in fluid communication with the first reservoir and positioned for piercing a first cartridge of a drug delivery device. A second piercing needle is provided and in fluid communication with the second reservoir and positioned for piercing a second cartridge contained with a drug delivery device. A manifold is positioned adjacent the inner body and comprises a fluid groove arrangement. A valve arrangement is positioned between the inner body and the manifold and controls fluid communication of a first fluid contained in the first cartridge and a second fluid contained in the second cartridge by way of the fluid groove arrangement to a holding chamber. The dispense interface may further comprise a lockout preventing dispense
The present invention relates to a drug delivery system with two-step targeting, which comprises a combination: (a) a lipid carrier provided with cell targeting agent(s) to target the drug delivery system to specific cells or tissues; and (b) a drug enclosed in said lipid carrier and provided with a DNA targeting agent to target the drug to the nuclei of specific target cells. Furthermore, the invention relates to a method of cancer therapy in which the above drug delivery system is administered to a cancer patient. The goal is to treat or analyse both large tumour masses as well as small tumour cell clusters and single spread tumour cells. According to the invention, drug uptake in tumours will be markedly increased at the same time as the interaction of the drug with healthy organs and tissues can be minimized. The invention gives potential to convert palliative into curative treatment.
The global Pulmonary Drug Delivery Systems Market report provides an accurate investigation of the different patterns and parameters affecting the industrial growth of the Pulmonary Drug Delivery Systems market at a global level. An assessment of the effect of the current situation and trends in the market is additionally included to provide an overview of the markets future position. The report provides the detailed information related to the global Pulmonary Drug Delivery Systems market dynamics and demonstrates superior forecast for the development of the market and its key competitors 3M, GSK, AstraZeneca, Cipla, Chiesi, Boehringer Ingelheim, Aptar, Novartis, Philips Respironics, Omron Healthcare, PARI, Skyepharma, CareFusion, Shanghai Huarui, Taian Character, Chia Tai Tianqing based on consistent information.. Apply here for the sample copy of the report @: Furthermore, The report presents a detailed segmentation Nebulizers, Dry ...
An extended release gastro-retentive drug delivery system of Valsartan. The drug delivery system contains a release portion containing the Valsartan, a gastro-retentive portion for retaining the drug
Research in novel drug delivery systems is being explored competitively in order to attain maximum therapeutic effect while minimizing the adverse effects. Despite several advancements in pharmaceutical formulations, one of the major challenges still persisting is sustained drug release. Microencapsulation enacts as an intelligent approach with a strong therapeutic impact and is in demand globally in medical technology due to its specific and attractive properties, including biocompatibility, stability, target specificity, uniform encapsulation, better compliance, and controlled and sustained release patterns that are responsible for diminishing the toxicity and dosage frequency. Microparticles are successful delivery systems that encapsulate both water-insoluble and sparingly water-soluble agents to elicit their efficacy with a great potential attributed to their unique properties: particle size, shape, structure, drug loading, entrapment efficiency, porosity, and release profile. Several ...
Designing new drug delivery systems requires tight control of drug release kinetics. Historically, polymers have been strong contenders in the field. However, achieving a narrow polydispersity and reducing batch-to-batch variability in synthesis can be difficult. Therefore researchers have expanded to other materials such as lipids, which mat have more favorable drug release properties. Lipids are a chemically unique category of molecules that plays a role in functionality and architecture of all living cells. Thus when used as materials for design of drug delivery systems, they will be considered biodegradable and biocompatible. In addition they offer more robust control over design of molecular architecture and thus directly impact the release kinetics of model drugs. The aim of this study was to better understand the mass transport mechanism involved in controlled release of a model drug from lipid based parenteral delivery systems. A family of dihydroxyacetone (DHA) derived symmetrical ...
This is part of the CCB Spring Seminar Series 2016.. Abbi Abdel Rehim/Sabrya Carim, University of Manchester A Novel Approach for Attaching Targeting Ligands to Liposomal Drug Delivery Systems/IPIP, a novel player in cell division Lab: Stephen High/Martin Lowe. ...
The invention relates to a process for preparing a time controlled, immediate release drug delivery system for oral administration of a first active ingredient to a subject in need thereof. The invention additionally relates to a dual drug delivery device, comprising the time controlled, immediate release drug delivery system according to the invention, further comprising a spray coating comprising a testosterone.
Scientific, peer-reviewed Dermatology article, indexed with MEDLINE/PubMed: Delivery Technologies Matter: Maximizing Efficacy and Minimizing Side Effects : No abstract available
To prevent water from flooding the structure and causing an immediate release of the drug, Grinstaff and his colleagues designed the air-filled, mesh-like material to be superhydrophobic-so water-resistant that droplets of water barely touch the surface, forming beads similar to those that appear on a freshly waxed car. They produced the porous polymer mesh using a process called electrospinning, which overlays micron-sized fibers upon one another. To control the rate of drug release, they adjusted chemical and physical properties of the material so that the entrapped air is loosely or tightly held. The more tightly held the air is within the structure, the harder it is for water to displace it, the slower the release, and the longer the treatment duration. Loaded with a widely used anti-cancer drug called SN-38 in in vitro experiments, the polymer mesh and internal air pocket proved to be robust and effective against lung cancer cells in solution for more than 60 days, indicating its ...
Lumenis Ltd. introduced an ophthalmic laser delivery technology and slit lamp biomicroscope system (InSight) at the recent annual meeting of the American Academy of Ophthalmology.
Now a day the use of herbal medicines has been increased all over the world due to their excellent and miraculous therapeutic effects and fewer side effects as compared to the modern medicines. Most of phytoconstituents of herbal extracts are water soluble and poorly miscible with oils and other lipids. Lipid solubility and molecular size of phytoconstituents are the major limiting factors for molecule to pass the biological membrane to be absorbed systemically following the oral or topical administration. The bioavailability of phytoconstituents can be increased by use of novel drug delivery system, which can increase the phytoconstituents solubility in gastrointestinal fluid as well as capacity to cross lipid rich biological membrane. Complexation of phytoconstituents with phospholipids or phosphotidylcholine results in novel drug delivery system called Phytosomes. The term phytosomes is coined from two different terms: phyto meaning plant and some meaning cell like. Phytosomes are small in size
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MDC Connects 2021. In this webinar, you will hear from the pioneers developing complex medicines and the challenges presented and overcome.
Local drug delivery medical devices are utilized to deliver therapeutic dosages of drugs, agents or compounds directly to the site where needed. The local drug delivery medical devices utilize various materials and coating methodologies to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
Global Intranasal Drug Delivery Devices Market by Manufacturers, Countries, Type and Application, Forecast to 2023. Intranasal drug delivery system is a medical device used for the administration of drugs for the treatment of local diseases in the nose and paranasal sinus such as allergic and non-allergic rhinitis and sinusitis. Intranasal Drug Delivery Devices are medical devices used for drug delivery through noses. Scope of the Report: This .... February 2018 , $3480 ,View Details>> ...
This independent 125 pages report guarantees you will remain better informed than your competition. With over 170 tables and figures examining the Sustained Release Ocular Drug Delivery Systems market, the report gives you a visual, one-stop breakdown of the leading products, submarkets and market leaders market revenue forecasts as well as analysis to 2025.. The report provides a basic overview of the Sustained Release Ocular Drug Delivery Systems industry including definitions, classifications, applications and industry chain structure. And development policies and plans are discussed as well as manufacturing processes and cost structures.. Primary sources are mainly industry experts from core and related industries, and suppliers, manufacturers, distributors, service providers, and organizations related to all segments of the industrys supply chain. The bottom-up approach was used to estimate the Global market size of Sustained Release Ocular Drug Delivery Systems Market based on end-use ...
A multidisciplinary approach is increasingly being adapted by the Pharmaceutical industry to tackle several challenges in developing efficacious treatment solutions. The field of Ophthalmology is no less different. Treatise on Ocular Drug Delivery is a unique collection of information put together by various experts in the field. One of the major goals behind this volume is to link clinical information with the current strategies employed in ocular drug delivery. This monograph covers a range of topics on ocular pharmacology. Chapters in the e-book cover several aspects of drug delivery research such as the biochemical background of specific eye diseases, challenges for ocular drug delivery, the role of influx and efflux transporters, novel drug delivery systems, pharmacokinetics, regulatory aspects, and patenting opportunities for researchers. This E-Book would serve as a suitable reference for pharmacy graduates, medical students, professional scientists and ophthalmic clinicians in academic ...
According to a new market report published by Transparency Market Research Pulmonary Drug Delivery Systems Market(Products- Metered Dose Inhalers, Dry Powder Inhalers and Nebulizers; Applications- Asthma, COPD and Cystic Fibrosis) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019, the global pulmonary drug delivery systems market was valued at USD 21.03billion in 2012 and is expected to grow at a CAGR of4.5% from 2013 to 2019, to reach an estimated value of USD 28.70billion in 2019.. Browse Global Pulmonary Drug Delivery Systems Market Report with Full TOC at Pulmonary drug delivery systems use the respiratory tract to deliver medications to treat diseases such as asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The history of use of these systems dates back to over 60 years ago, when these systems were initially indicated for treating only respiratory ...
Principal Investigator:KUZUYA Masayuki, Project Period (FY):1992 - 1993, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Physical pharmacy
Carboxymethyl-chitosan/Poly(amidoamine) Dendrimer Nanoparticles as Intracellular Drug Delivery Systems in Central Nervous System Regenerative Medicine: Effects on Neurons/Glial Cell Viability/Proliferation and Internalization Efficiency ...
Global Drug Delivery Technologies Market Size, Status and Forecast 2025 is a market research report available at US $3300 for a Single User PDF License from RnR Market Research Reports Library.
Various efforts in ocular drug delivery have been made to improve the bioavailability and to prolong the residence time of drugs applied topically onto the eye. . The present presentation includes | Basics of drug delivery systems | General aspects for design and development of DDS | General concepts of ocular drug delivery routes | various pros and cons of ocular drug therapy
TY - JOUR. T1 - Liposomal drug delivery system. AU - Maruyama, Kazuo. AU - Kennel, Stephen. AU - Huang, Leaf. PY - 1990/8/1. Y1 - 1990/8/1. N2 - We have recently described an immunoliposome targeting system which involves the use of monoclonal antibodies specific for the pulmonary endothelial cells. We have employed the antibodies, 34A and 201B, which bind to a surface glycoprotein, gp112, which is specifically expressed in high concentrations in the capillary endothelial cells of the mouse lung. Intravenously injected immunoliposomes (34A- or 201B-liposomes) to the mice gain direct access and bind efficiently to the lung. Approximately 50% of the injected dose was accumulated in the lung for 34A-liposomes which contained an average of 935 antibody molecules per liposome. Lung accumulation of 34A-liposomes is completely blocked by a preinjection of free antibody 34A, indicating that the immunoliposome accumulation at the target site is immunospecific. The level of lung accumulation increases ...
A transdermal drug delivery device for the controlled transdermal delivery of an active pharmaceutical agent. The device comprises a drug delivery device comprising an active pharmaceutical agent and a means for its controlled delivery through the skin; and (B) a silicone pressure sensitive adhesive for maintaining contact between the device and the skin of a wearer. The silicone pressure sensitive adhesive comprises silicone resin copolymer and a polydiorganosiloxane and has a silanol concentration in the range of between about 8000 and about 13,000 ppm. The present invention also relates to methods for producing the above silicone pressure sensitive adhesive compositions.
Based on the results, drug loaded solid lipid nanoparticles can provide an alternative to the current available therapy in hypertension by solving the practical problems of poor solubility, low oral absorption and reduced bioavailability
TY - JOUR. T1 - Sustained release nitric oxide releasing nanoparticles. T2 - Characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites. AU - Friedman, Adam J.. AU - Han, George. AU - Navati, Mahantesh S.. AU - Chacko, Manju. AU - Gunther, Leslie. AU - Alfieri, Alan. AU - Friedman, Joel M.. N1 - Funding Information: The work was partially supported by DOD Grant DAMD17-03-1-0127. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2008/8. Y1 - 2008/8. N2 - A new platform using biocompatible materials is presented for generating powders comprised of nanoparticles that release therapeutic levels of nitric oxide (NO) in a controlled and sustained manner. The capacity of these particles to retain and gradually release NO arises from their having combined features of both glassy matrices and hydrogels. This feature allows both for the generation of NO through the thermal reduction of added nitrite by glucose and for the retention of the ...
Nanoparticles have attracted increasing attention for local drug delivery to the inner ear recently. Bovine serum albumin (BSA) nanoparticles were prepared by desolvation method followed by glutaraldehyde fixation or heat denaturation. The nanoparticles were spherical in shape with an average diameter of 492 nm. The heat-denatured nanoparticles had good cytocompatibility. The nanoparticles could adhere on and penetrate through the round window membrane of guinea pigs. The nanoparticles were analyzed as drug carriers to investigate the loading capacity and release behaviors. Rhodamine B was used as a model drug in this paper. Rhodamine B-loaded nanoparticles showed a controlled release profile and could be deposited on the osseous spiral lamina. We considered that the bovine serum albumin nanoparticles may have potential applications in the field of local drug delivery in the treatment of inner ear disorders.
...NEW YORK April 5 2011 /- announces tha...a href href report deals with transdermal drug delivery - an approach used to...,Reportlinker,Adds,Transdermal,Drug,Delivery,-,Technologies,,Markets,,and,Companies,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
Discuss and stay updated on the latest in drug development, diagnostics at clinical pharmacy events, industrial pharmacy conferences, medicinal chemistry meetings at Abu Dhabi in 2020, 2021 from Thailand, Russia, India, Philippines, China
Access submits additional patent applications for Cobalamin-mediated oral medication delivery technology ACCESS PHARMACEUTICALS, INC. , a biopharmaceutical firm leveraging its proprietary drug-delivery platforms to build up treatments in regions of oncology, cancers supportive diabetes and care, announced it has submitted extra patent applications, covering its Cobalamin-mediated oral drug delivery technology formulations of many global best-100 injectable drugs, as a result of the growing curiosity surrounding the companys proprietary oral delivery technology. The CobOral branding and additional patent filings reflect the high level of interest from partners in our CobOral and CobaCyte medication delivery platforms, stated Jeffrey B. Davis, President and CEO, Gain access to Pharmaceuticals, Inc. Related StoriesNew RNA check of blood platelets can be used to identify location of cancerStudy shows rare HER2 missense mutations usually do not spread breasts cancer on their ownSausages With ...
1.2.5 Nanotubes. 1.2.6 Others. 1.3 Applications of Nanotechnology Drug Delivery. 1.3.1 Neurology. 1.3.2 Oncology. 1.3.3 Cardiovascular/Physiology. 1.3.4 Anti-inflammatory/Immunology. 1.3.5 Anti-infective. 1.3.6 Others. 1.4 Market Segment by Regions. 1.4.1 North America. 1.4.2 China. 1.4.3 Europe. 1.4.4 Southeast Asia. 1.4.5 Japan. 1.4.6 India. 2 Manufacturing Cost Structure Analysis of Nanotechnology Drug Delivery. 2.1 Raw Material and Suppliers. 2.2 Manufacturing Cost Structure Analysis of Nanotechnology Drug Delivery. 2.3 Manufacturing Process Analysis of Nanotechnology Drug Delivery. 2.4 Industry Chain Structure of Nanotechnology Drug Delivery. Send An Enquiry Request @ 3 Technical Data and Manufacturing Plants Analysis of Nanotechnology Drug Delivery. 3.1 Capacity and Commercial Production Date of Global Nanotechnology Drug Delivery Major Manufacturers in 2016. 3.2 Manufacturing Plants Distribution of Global Nanotechnology Drug ...
Liposomes have been evolving as unique drug carriers for realizing enhanced efficacy and/or reduced toxicity.1) Currently, several liposomal drug delivery systems are on the market, and practically all of them are administered parenterally. Liposomes are also investigated for oral delivery, especially for active ingredients with extremely low oral bioavailability, such as poorly soluble compounds. The aim of this project is to study the mechanisms underlying the bioavailability improvement of poorly soluble compounds entrapped in liposomes as oral drug delivery systems. We will start by studying the mechanisms of liposome digestion and drug solubilization and the efficiency of subsequent association of the entrapped compounds into mixed micelles, using a highly relevant in vitro human digestion model and dedicated analysis methods.2)3)4) In the second part of the project, we will study the permeability of the compounds after in vitro digestion, using an in vitro permeability model consisting of ...
Article Preparation and characterisation of 5-fluorouracil containing PLGA nanospheres coated with chitosan, for drug delivery. The aim of this study was to design a new Drug Delivery System (DDS) based on poly (lactide-co-glycolide) (PLGA) biodegrad...
The present invention comprises a transdermal drug delivery device comprising a reservoir comprising a releasably stored dosage of a pharmaceutically active agent and a translucent film adjacent to at least a portion of the reservoir, wherein the translucent film comprises at least one inorganic ultraviolet-absorbing compound. The present invention also comprises a method of drug delivery to a mammal using such devices.
Objective: Biologicals targeting epidermal growth factor (EGF) and interleukin 13 receptors not only react with overexpressed markers on cancer cells but also react with receptors on normal cells. Because we developed novel bispecific ligand-directed toxins synthesized by cloning EGF and interleukin 13 on the same molecule with toxin, our objective was to determine whether we could block normal receptors while still targeting receptors overexpressed on cancer cells, thereby decreasing toxicity while maintaining efficacy. Methods: A method, toxicity blocking (ToxBloc), was developed in which a bolus intraperitoneal dose of recombinant EGF13 (without toxin) was given to mice approximately 15 to 20 minutes before DTEGF13. Experiments were then performed to determine whether the maximal tolerated dose (MTD) was reduced and whether we were still able to eliminate progression of aggressive human, metastatic, pancreatic cancer induced by orthotopic injection (OT) in nude mice. Results: ToxBloc ...
New drug-delivery systems have remained a challenge for pharmaceutical scientists due to the use of expensive polymers and the low loading capacity of prepared nanoparticles. There is pressure to develop formulations that contain not only cheaper materials but also have controlled-release properties. Halloysite nanotubes (HNTs) are a naturally occurring clay mineral similar to kaolin, possessing a special particle shape in the form of an ultramicroscopic multilayered hollow cylinder. Its uses encompass a wide range in anticancer therapy, sustained- and controlled-release drug-delivery systems, cosmetics, delivery of proteins, vaccines and genes. These advantages are due to its biocompatibility, significant mechanical strength and natural availability. The surfaces of the tubules can be modified by coating different polymers for application in the drug-delivery system. This review is focused on the various aspects of HNTs such as structure, properties, loading methods, applications and ...
Pulmonary segment covers metered dose inhalers, dry-powder inhalers and nebulizers; this segment is growing at the highest CAGR of 11.8%. The transdermal technology market is divided into two types, namely, passive drug delivery and active drug delivery. Passive delivery is further categorized into reservoir system and matrix system, while active delivery is further categorized into iontophoresis, microporation and other technologies such as electroporation, sonophoresis and dermal ablation. Injectable technology market is classified as conventional injection, self injection, and other injection devices. Conventional devices include fillable syringes and prefilled syringes, whereas self injection devices include needle free injectors, auto-injectors, and pen injectors ...
Lectins are carbohydrate recognizing proteins originating from diverse origins in nature, including animals, plants, viruses, bacteria and fungus. Due to their exceptional glycan recognition property, they have found many applications in analytical chemistry, biotechnology and surface chemistry. This manuscript explores the current use of lectins for cancer diagnosis and therapy. Moreover, novel drug delivery strategies aiming at improving lectins stability, reducing their undesired toxicity and controlling their non-specific binding interactions are discussed. We also explore the nanotechnology application of lectins for cancer targeting and imaging. Although many investigations are being conducted in the field of lectinology, there is still a limited clinical translation of the major findings reported due to lectins stability and toxicity concerns. Therefore, new investigations of safe and effective drug delivery system strategies for lectins are warranted in order to take full advantage of these
In this work, new efficient drug delivery systems based on cellulose nanofiber-titania nanocomposites grafted with three different types of model drugs such as diclofenac sodium, penicillamine-D and phosphomycin were successfully synthesized and displayed distinctly different controlled long-term release pro
Doctors in Boston may have found a way around one of the biggest limitations of chemotherapy in patients with malignant mesothelioma.
9780444820273 Advances in Drug Delivery Systems, 6: Proceedings of the Sixth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City,,books, textbooks, text book
Pioneering new treatment category - site-specific delivery of drugs to the brain MIDDLEBURG, Va., and DENVER, April 28, 2011 /PRNewswire-USNewswire/ -- Epilepsy Therapy Project (ETP), a non-profit
ABSTRACT. Buccal administration of drug provides a convenient route of administration for both systemic and local drug actions. The preferred site for retentive oral transmucosal delivery systems and for sustained and controlled release delivery device is the buccal mucosa. Rapid developments in the field of molecular biology and gene technology resulted in generation of many macromolecular drugs including peptides, proteins, polysaccharides and nucleic acids in great number possessing superior pharmacological efficacy with site specificity and devoid of untoward and toxic effects. However, the main impediment for the oral delivery of such drugs as potential therapeutic agents is their extensive presystemic metabolism, instability in acidic environment resulting into inadequate and erratic oral absorption. Direct access to the systemic circulation through the internal jugular vein bypasses drug from the hepatic first pass metabolism leading to high bioavailability. The objective of this article ...
Infections caused by microorganisms like bacteria, fungi, etc. are the main obstacle in healing processes. Conventional antibacterial administration routes can be listed as oral, intravenous/intramuscular, topical and inhalation. These kinds of drug administrations are faced with critical vital issues such as; more rapid delivery of the drug than intended which can result in bacterial resistance, dose related systemic toxicity, tissue irritation and finally delayed healing process that need to be tackled. Recently, studies have been focused on new drug delivery systems, overcoming resistance and toxicological problems and finally localizing the molecules at the site of action in a proper dose. In this regard, many nanotechnological approaches such as nanoparticulate therapeutic systems have been developed to address accompanying problems mentioned above. Among them, drug loaded electrospun nanofibers propose main advantages like controlled drug delivery, high drug loading capacity, high ...
The present work aims at computational analysis of environmentally responsive hydrogels with enormous prospective in the formulation aspect of drug delivery systems. The drug delivery potential of hydrogels to the targets is owing to the specific stimuli responsive nature of the hydrogels. The environmental factors looked upon in the study are changes in pH, alteration of temperature and glucose concentration rise originated in the body as a result of various disease conditions. Polymers, synthetic polypeptides and dendrimers have been used in the present work to study the feasibility of drug delivery. The computational methods have been used to formulate polymer properties, pharmacokinetics and toxicity studies. Diverse interactions approximating electrostatic, hydrophobic and hydrogen bond interactions acquire place during incorporation of drugs within the polymer and dendrimers. The covalent and electrostatic interactions between a drug and the surface of polymer and dendrimer have been ...
TY - JOUR. T1 - Excipient-free porphyrin/SN-38 based nanotheranostics for drug delivery and cell imaging. AU - Yuan, Ye. AU - Bo, Ruonan. AU - Jing, Di. AU - Ma, Zhao. AU - Wang, Zhongling. AU - Lin, Tzu yin. AU - Dong, Lijie. AU - Xue, Xiangdong. AU - Li, Yuanpei. PY - 2020/1/1. Y1 - 2020/1/1. N2 - Nanotheranostics with comprehensive diagnostic and therapeutic capabilities show exciting cancer treatment potentials. Here, we develop an excipient-free drug delivery system for cancer diagnosis as well as therapy, in which a near infra-red photosensitizer and a chemotherapeutic drug can be self-delivered without any carriers. The building block of the drug delivery system was synthesized by covalently conjugating four anticancer drugs (7-ethyl-10-hydroxy-camptothecin, SN-38) with a photosensitizer (porphyrin) via hydrolyzable ester linkage, which endows the drug delivery system with 100% active pharmaceutical ingredients, excellent imaging, and therapeutic functionalities. The conjugates can ...
Tumor-targeted drug delivery systems and uses thereof - The present invention relates to targeted delivery systems for delivering therapeutic agents to tumor. The invention further relates to methods of delivering a therapeutic agent to a tumor for the prevention and treatment of cancer by killing tumor cells and tumor-associated endothelial cells. In particular, the present invention provides a tumor-targeted drug delivery system comprising a NGR-containing molecule linked to a delivery vehicle encapsulating a therapeutic agent, preferably a drug, such as a cytotoxic agent or a chemotherapeutic agent. Specifically, the delivery systems of the present invention are capable of delivering an increased amount of therapeutic agent to a tumor as compared to other delivery systems. In particular, the delivery systems of the present invention are capable of accumulating a higher amount of therapeutic agent in a tumor, or in the vicinity of a tumor cell or tumor-supporting cell, resulting in exposure of ...
Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients average 5 year survival rate from 20% to 70% in the past 30 years. However, for patients who progress after chemotherapy, its effectiveness diminishes due to the emergence of multi-drug resistance (MDR) after prolonged therapy. Methodology/Principal Findings: In order to overcome both the dose-limiting side effects of conventional chemotherapeutic agents and the therapeutic failure resulting from MDR, we designed and evaluated a novel drug delivery system for MDR1 siRNA delivery. Novel biocompatible, lipid-modified dextran-based polymeric nanoparticles were used as the platform for MDR1 siRNA delivery; and the efficacy of combination therapy with this system was evaluated. In this study, multi-drug resistant osteosarcoma cell lines (KHOSR2 and U-2OSR2) were treated with the MDR1 siRNA nanocarriers and MDR1 protein (P-gp) expression, drug retention, and immunofluoresence were analyzed. Combination therapy of
0006] According to one aspect an assembly for a drug delivery device is provided. The assembly may comprise a housing. The assembly may comprise a rotation member. The rotation member may be adapted to be rotated with respect to the housing in a first rotational direction for delivering a dose of a drug. The first rotational direction may be counter-clockwise, for example. The assembly may comprise a drive member. The drive member may be, preferably releasably, coupleable to the rotation member for delivering the dose. The assembly may comprise at least one correction member. In a delivery mode, the drive member and the rotation member are expediently coupled such that the drive member follows rotational movement of the rotation member in the first rotational direction due to mechanical interaction of the rotation member and the drive member, e.g. the rotation member and the drive member may be rotationally locked. In the delivery mode, the rotation member and, hence, the drive member may rotate ...
In this work, novel nanostructured core-shell poly(ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ζ potential of the pure nanostructured core-shell PEG-POSS and the corresponding insulin-loaded PEG-POSS nanoparticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that insulin was well-protected inside PEG-POSS nanoparticles at gastric pH for 2hrs, and was released at intestinal pH (pH 6-7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems.
The explicit use of colon-specific drug delivery systems is for the local treatment of colon diseases such as ulcerative colitis. Some efficient therapeutic systems, primarily prodrugs and polymeric carriers of salicylate derivatives, have been developed and commercialized during the past 20 years. Speculating that the colon is a superior organ for peptide drug absorption after oral ingestion, many studies indicate that colon-specific drug carriers may potentially be used for the delivery of peptide drugs to that organ. This notion stems from the assumption that the overall proteolytic activity in the colon is lower than and different from the proteolytic activity in the small intestine. For example, it has been found that the degradation rate of albumin, azoalbumin casein, azocasein and collagen in human ileal effluent was faster than the degradation rate in fecal slurries. Other studies, in which the degradation rates of insulin and insulin B-chain in the small and large intestine of the ...
SMi Group announces the 15th Annual Controlled Release Delivery Conference in London on March 21st - 22nd 2018. As physicians continue to request drugs which have a reduced dosage requirement, higher action times and assist in simplifying treatment schedules for patients, the focus of the pharmaceutical industry is continually moving towards innovative controlled release delivery technologies, which improve drug transport to the target.. This years event will bring together industry experts from pharmaceutical companies, regulatory agencies and biotechs to analyze and evaluate the latest advancements in Controlled Release Delivery, including the addressing formulation challenges of Abuse-Deterrent and oral lipid based Formulations, targeting controlled release delivery with Polymer Nanoparticles and how to overcome the additional challenges in controlled release delivery for pediatric medicine.. With the Oral Controlled Release Drug Delivery Technology Market expected to be worth $ 50,000 Mn in ...
Global market for implantable drug delivery devices was calculated at USD 11.6 billion and is expected to grow at a CAGR of 8.8% from 2012 to 2018, to reach an estimated value of USD 21.1 billion in 2018. The North American implantable drug delivery devices market share held majority of the market share in 2011.
Objectives: Direct pulp capping is a treatment for preserving the vital pulp. However, a satisfactory material for caries-exposed inflamed pulp in permanent teeth is not currently available. Thus, a biologically-based material that promotes the continued formation of a new dentin-pulp complex is needed. A hydrogel drug delivery vehicle is a promising material, however its cytotoxicity has barely been explored. The aim of this study is to evaluate the cytotoxicity of a hydrogel drug delivery vehicle and its components in a cell culture system in vitro. Methods: The hydrogel solution was prepared by mixing poly(ethylene glycol)maleate-citrate (45% w/v)[PEGMC], acrylic acid (5% w/v)[AA], 2,2-Azobis(2-methylpropionamidine) dihydrochloride photoinitiator (0.1% w/v)[AAPH], and deionized water. Various concentrations of the hydrogel and its components were prepared in the cell culture medium. L929 cells were seeded into 96-well plates at 3x103 cells/well and cultured with each concentration of the ...
Photodynamic therapy of a 2-methoxyestradiol tumor-targeting drug delivery system mediated by Asn-Gly-Arg in breast cancer Jinjin Shi, Zhenzhen Wang, Lei Wang, Honghong Wang, Lulu Li, Xiaoyuan Yu, Jing Zhang, Rou Ma, Zhenzhong ZhangSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of ChinaAbstract: Fullerene (C60) has shown great potential in drug delivery. In this study we exploited modified fullerene (diadduct malonic acid-fullerene-Asn-Gly-Arg peptide [DMA-C60-NGR]) as an antitumor drug carrier in order to build a new tumor-targeting drug delivery system. We also investigated the synergistic enhancement of cancer therapy using photodynamic therapy (PDT) induced by DMA-C60-NGR and 2-methoxyestradiol (2ME). Cytotoxicity tests indicated that DMA-C60-NGR had no obvious toxicity, while our drug delivery system (DMA-C60-2ME-NGR) had a high inhibition effect on MCF-7 cells compared to free 2ME. The tumor-targeting drug delivery system could efficiently cross cell
Inorganic matrices and biopolymers have been widely used in pharmaceutical fields. They show properties such as biocompatibility, incorporation capacity, and controlled drug release, which can become more attractive if they are combined to form hybrid materials. This work proposes the synthesis of new drug delivery systems (DDS) based on magnesium phyllosilicate (Talc) obtained by the sol-gel route method, the biopolymer chitosan (Ch), and the inorganic-organic hybrid formed between this matrix (Talc + Ch), obtained using glutaraldehyde as a crosslink agent, and to study their incorporation/release capacity of amiloride as a model drug. The systems were characterized by X-ray diffraction (XRD), Therma analysis TG/DTG, and Fourier-transform infrared spectroscopy (FTIR) that supported the DDSs formation. The hybrid showed a better drug incorporation capacity compared to the precursors, with a loading of 55.74, 49.53, and 4.71 mg g-1 for Talc + Ch, Talc, and Ch, respectively. The release assays ...
University of Delaware Professor Kristi Kiick is leading collaborative research to create new drug delivery systems with the potential to improve treatment for diseases that affect connective tissues, such as osteoarthritis or rheumatoid arthritis, which is an autoimmune disease.. The UD researchers have devised tiny cargo-carrying systems many times smaller than a human hair. These systems, or carriers, are made from molecules called peptides that help provide structure for cells and tissues.. The research team is working to program these nanoparticle carriers to selectively bind to degrading collagen in the body. Collagen is a protein that helps plump up or provide structure to connective tissue-everything from our skin to our bones, tendons and ligaments.. When collagen degrades, as a result of disease or injury, the nanoparticles designed by the Kiick lab can attach and remain at the injury site longer than many current treatment options. This allows for the possibility of delivering ...
Grant Number: JPMJER1101. The biologics including proteins, nucleic acids and extracellular vesicles (exosomes) have been attracted attention as innovative pharmaceutical products in advanced nanomedicine. In this project, new bio-nanotransporters (bio-inspired nanoparticles) have been developed for new drug delivery systems(DDS) especially for such biologics to apply cancer immuno-therapies, vaccines and tissue engineering. We proposed nanogel tectonics using self-assembled nanogels as building blocks to construct multi functional well-controlled gel biomaterials, e.g. artificial cellular matrix and tissue scaffold. Proteoliposomes were efficiently prepared by cell-free membrane protein synthesis with liposome chaperone (artificial cell method) for bio-analysis and DDS. New strategy for functionalization of exosomes has been developed by fusion with nanogel engineering and liposome engineering. Functions of T cell derived exosomes for cancer microenvironment were newly found and the exosomes ...
Nanomedicine is an emerging area in the medical field, particularly in the treatment of cancers. Nanostructured lipid carrier (NLC) was shown to be a good nanoparticulated carrier for the delivery of tamoxifen (TAM). In this study, the tamoxifen-loaded erythropoietin-coated nanostructured lipid carriers (EPO-TAMNLC) were developed to enhance the anti-cancer properties and targetability of TAM, using EPO as the homing ligand for EPO receptors (EpoRs) on breast cancer tissue cells. Tamoxifen-loaded NLC (TAMNLC) was used for comparison. The LA7 cells and LA7 cell-induced rat mammary gland tumor were used as models in the study. Immunocytochemistry staining showed that LA7 cells express estrogen receptors (ERs) and EpoRs. EPO-TAMNLC and TAMNLC significantly (p|0.05) inhibited proliferation of LA7 in dose- and time-dependent manner. EPO-TAMNLC induced apoptosis and G0/G1 cell cycle arrest of LA7 cells. Both drug delivery systems showed anti-mammary gland tumor properties. At an intravenous dose of 5 mg kg-1
Tamara Minko is Professor of Pharmaceutics at the Ernest Mario School of Pharmacy in the Department of Pharmaceutics at Rutgers, The State University of New Jersey. Prof. Minkos research interests include drug delivery; biopharmaceutics; nanotechnology for cancer detection and treatment; molecular targeting; antisense oligonucleotides, siRNA and peptides in cancer therapy; mechanisms of multidrug resistance; intracellular fate and molecular mechanisms of action of anticancer drugs: apoptosis and necrosis, signal transduction, antiapoptotic cellular defensive mechanisms; use of macromolecules for drug delivery; preclinical evaluation of anticancer drugs; tumor hypoxia; modulation of cell death mechanisms during hypoxia.Speaking in the special symposium on Nanotechnology for Cancer Prevention, Diagnosis and Treatment.
CORVALLIS, Ore. - Researchers have developed a new drug delivery system that allows inhalation of chemotherapeutic drugs to help treat lung cancer, and in laboratory and animal tests it appears to reduce the systemic damage done to other organs while significantly improving the treatment of lung tumors.. This advance in nanomedicine combines the extraordinarily small size of nanoparticles, existing cancer drugs, and small interfering RNA (siRNA) that shut down the ability of cancer cells to resist attack.. The combination of these forces resulted in the virtual disappearance of lung tumors in experimental animals.. Lung cancer is the leading cancer killer in both men and women. Despite advances in surgery, chemotherapy still plays a major role in its treatment. However, that treatment is constrained by the toxic effects of some drugs needed to combat it and the difficulty of actually getting those drugs into the lungs.. The findings were made by Oleh Taratula at Oregon State University and ...
This chapter aims to provide the readers a comprehensive review of the current trends and approaches used in the development of ocular drug delivery systems. After the introduction to the topic, the c
... "smart drug delivery" originated. Encapsulated within the idea of smart drug delivery is the use of gated delivery systems. ... Gated drug delivery systems are a recent innovation in the field of drug delivery and pose as a promising candidate for future ... These smart drug delivery systems are able to delivery the drug with minimal leakage, can be actively or passively targeted to ... The history of gated drug delivery systems starts in the mid-1960s when the concept of zero order controlled drug delivery was ...
The exact biological mechanisms by which dextran-based drug delivery systems act on the drug target must be elucidated as well ... Microspheres composed of dextran have several advantages as a drug delivery system including controlled drug release, localized ... These drug-polymer complexes have advantages such as longer drug half-life and improved targeted drug delivery. Dextran ... Dextran-based drug delivery systems have an enormous potential for clinical use in the treatment of a variety of disease states ...
... the development of stimuli-responsive drug delivery systems has created the ability to tune drug delivery systems to achieve ... Redox-responsive drug delivery systems are also used in the delivery of DNA and siRNA for gene therapy.. Redox-responsive drug ... pH-responsive drug delivery systems are particularly suitable for the design of chemotherapeutic delivery systems due to the ... As a result, the drug is released from the system. pH responsive drug delivery systems are typically synthesized from pH- ...
A self-microemulsifying drug delivery system (SMEDDS) is a drug delivery system that uses a microemulsion achieved by chemical ... "Self-emulsifying drug delivery systems in oral (poly)peptide drug delivery". Expert Opin Drug Deliv. 12 (11): 1703-1716. doi: ... "Self-nano-emulsifying drug delivery systems: an update of the biopharmaceutical aspects". Expert Opinion on Drug Delivery. 12 ( ... Attama AA; Nkemnele MO (November 2005). "In vitro evaluation of drug release from self micro-emulsifying drug delivery systems ...
The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release ... Targeted drug delivery systems have been developed to optimize regenerative techniques. The system is based on a method that ... The goal of a targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with the ... Active targeting can also be achieved through peptide based drug targeting system. There are different types of drug delivery ...
... drug-targeting Drug delivery to the brain Drug carrier Magnetic drug delivery Neural drug delivery systems Retrometabolic drug ... design Self-microemulsifying drug delivery system Tecrea Thin film drug delivery "Drug Delivery Systems (definition)". www. ... drug carriers, 3D printing, and the delivery of biologic drugs. Targeted drug delivery is the delivery of a drug to its target ... Jain, Kewal K. (2020), Jain, Kewal K. (ed.), "An Overview of Drug Delivery Systems", Drug Delivery Systems, Methods in ...
Kreuter, Jörg (2001). "Nanoparticulate systems for brain delivery of drugs". Advanced Drug Delivery Reviews. 47 (1): 65-81. doi ... "Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?". Advanced Drug Delivery Reviews. 71: ... PBCA, chitosan, and PLGA nanoparticles were used as delivery systems for these drugs. Overall, the results from each drug ... Metal nanoparticles are promising as carriers for drug delivery to the brain. Common metals used for nanoparticle drug delivery ...
"Intracochlear drug delivery systems: a novel approach whose time has come". Expert Opinion on Drug Delivery. 15 (4): 319-324. ... "Non-dermal applications of microneedle drug delivery systems". Drug Delivery and Translational Research. doi:10.1007/s13346-021 ... Kim YC, Park JH, Prausnitz MR (November 2012). "Microneedles for drug and vaccine delivery". Advanced Drug Delivery Reviews. 64 ... "Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery". Drug Delivery and Translational ...
Abdus, S., Y. Sultana, and M. Aqil, Liposomal Drug Delivery Systems: An Update Review. Current Drug Delivery, 2007. 4(4): p. ... Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled ... Ma, Y., R.J.M. Nolte, and J.J.L.M. Cornelissen, Virus-based nanocarriers for drug delivery. Advanced Drug Delivery Reviews, ... Current nanoparticle drug delivery systems can be cataloged based on their platform composition into several groups: polymeric ...
Nervous System Drug Delivery. Academic Press. pp. 3-20. doi:10.1016/b978-0-12-813997-4.00001-3. ISBN 978-0-12-813997-4. S2CID ... February 2016). "Systems Proteomics View of the Endogenous Human Claudin Protein Family". Journal of Proteome Research. 15 (2 ... A recent review discusses evidence regarding the structure and function of claudin family proteins using a systems approach to ... Hou J (2019-01-01). "Chapter 7 - Paracellular Channel in Organ System". In Hou J (ed.). The Paracellular Channel. Academic ...
Nervous System Drug Delivery. Academic Press. pp. 3-20. doi:10.1016/b978-0-12-813997-4.00001-3. ISBN 978-0-12-813997-4. S2CID ... Within the Sertoli cells of the male reproductive system, JAM-3 interacts with JAM-2 to influence the polarity of both round ... 3 has been shown to be a primary regulator of the development of spermatids as well as the rest of the male reproductive system ...
His research is focused on the design and physicochemical characterisation of advanced polymeric drug delivery systems for ... "Mucoadhesive drug delivery systems". Journal of Pharmacy and Bioallied Sciences. 3 (1): 89-100. doi:10.4103/0975-7406.76478. ...
The first modern remote drug-delivery system was invented by scientists at the University of Georgia in the 1950s, and was the ... "Remote Drug Delivery Systems". Journal of Zoo and Wildlife Medicine. 23 (2): 159-180. JSTOR 20095205. С. Успенский. ... If you shot somebody who was big or had drugs in their system, it might not do anything." says Newett, of the Justice ... "Drugged beverages are so much easier to conceal," explains Dr. Theodore Davantzis. The only person who has been suspected to ...
... in drug delivery systems, the mucus layer must be penetrated in order to effectively transport micro- or nanosized drug ... "Nasal mucoadhesive drug delivery: Background, applications, trends and future perspectives". Advanced Drug Delivery Reviews. 57 ... Boddupalli, Bindu M.; Mohammed, Zulkar N.K.; Nath, Ravinder A.; Banji, David (2010). "Mucoadhesive drug delivery system: An ... Bernkop-Schnürch, A; Dünnhaupt, S (August 2012). "Chitosan-based drug delivery systems". Eur J Pharm Biopharm. 81 (3): 463-469 ...
Burgess, A., & Hynynen, K. (2016). Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System. ... of drugs from accessing the central nervous system, so FUS has the potential to address a major challenge in intracranial drug ... "Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for ... "Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for ...
Researchers have devised ways to use smart polymers to control the release of drugs until the delivery system has reached the ... Many creative approaches to targeted drug delivery systems that self-regulate based on their unique cellular surroundings, are ... recognition and finally produced awareness systems and polymer carriers to facilitate drug delivery in the body system. Several ... Polymers for drug delivery systems. HHS Author Manuscripts. Journal List. PMC. (Articles needing additional references from ...
Robb Pharmaceutical Systems for Drug Delivery, David Jones; Chien YW. 2nd ed. New York: Marcel Dekker, Inc; 1993. Novel drug ... meaning delivery of the drug settles to a constant rate. This is crucial in drug delivery and is used in cases such as the ... Medical Uses: Permeation can also be seen in the medical field in drug delivery. Drug patches made up of polymer material ... delivery systems. O.V. Malykh, A.Yu. Golub, V.V. Teplyakov, "Polymeric membrane materials: New aspects of empirical approaches ...
Neurotoxicity concern about the brain targeting delivery systems". In Gao H, Gao X (eds.). Brain Targeted Drug Delivery System ... FUCCI is a system that takes advantage of cell cycle phase-specific expression of proteins and their degradation by the ... Hydroxyurea (HU) is a small molecule drug that inhibits the enzyme ribonucleotide reductase (RNR), preventing the catalysis of ... Xu K, Schwarz PM, Ludueña RF (Feb 2002). "Interaction of nocodazole with tubulin isotypes". Drug Development Research. 55 (2): ...
Gupta S, Dhanda S, Sandhir R (2019). "Anatomy and physiology of blood-brain barrier". Brain Targeted Drug Delivery System. ... Mechanisms for drug targeting in the brain involve going either "through" or "behind" the BBB. Modalities for drug delivery to ... to overcome this barrier some peptides able to naturally cross the BBB have been widely investigated as a drug delivery system ... Silva GA (December 2008). "Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS". BMC ...
... s have been investigated for drug delivery. Polymeric drug delivery systems have overcome challenge due to their ... "Physical hydrogels with self-assembled nanostructures as drug delivery systems". Expert Opinion on Drug Delivery. 8 (9): 1141- ... Qiu Y, Park K (December 2001). "Environment-sensitive hydrogels for drug delivery". Advanced Drug Delivery Reviews. 53 (3): 321 ... Sustained-release drug delivery systems. Ionic strength, pH and temperature can be used as a triggering factor to control the ...
Polymers for Drug Delivery Systems. 97, Part B (Pt B): 338-349. doi:10.1016/j.ejpb.2015.05.017. PMID 26614556. Blacklow, S.; Li ... Advanced Drug Delivery Reviews. Matrices and Scaffolds for Drug Delivery in Tissue Engineering. 59 (4-5): 263-273. doi:10.1016/ ... Current research efforts focus on water-based applications like drug delivery systems, tissue engineering, bioseparation (see ... Kretlow, James D.; Klouda, Leda; Mikos, Antonios G. (May 30, 2007). "Injectable matrices and scaffolds for drug delivery in ...
Ranade VV, Cannon JB (2011). Drug Delivery Systems (3rd ed.). CRC Press. p. 337. ISBN 978-1-4398-0618-0. Archived from the ... Srikrishna S, Cardozo L (April 2013). "The vagina as a route for drug delivery: a review". International Urogynecology Journal ... Human female reproductive system, Mammal female reproductive system, Women and sexuality, Women's health, Anatomy, Gynaecology) ... The opening to the vagina is normally obscured by the labia minora (vaginal lips), but may be exposed after vaginal delivery. ...
Chu, Dafeng; Dong, Xinyue; Shi, Xutong; Zhang, Canyang; Wang, Zhenjia (2018). "Neutrophil-Based Drug Delivery Systems". ... "Multifunctional Bacteria-Driven Microswimmers for Targeted Active Drug Delivery". ACS Nano. 11 (9): 8910-8923. doi:10.1021/ ... "Bioadhesive Bacterial Microswimmers for Targeted Drug Delivery in the Urinary and Gastrointestinal Tracts". Advanced Science. 4 ... Finally, excitable systems operating close to bifurcations may admit limit cycles, which manifest as repetitive or rhythmic ...
Tønnesen, Hanne Hjorth; Karlsen, Jan (1 January 2002). "Alginate in Drug Delivery Systems". Drug Development and Industrial ... Alginates are the natural product of brown algae and have been used extensively in wound dressing, drug delivery and tissue ...
Transdermal and Topical Drug Delivery Systems. Informa Health Care. ISBN 1-57491-041-8. American Society of Health-System ... Fentanyl Transdermal System (marketed as Duragesic and generics)". US Food and Drug Administration Postmarket Drug Safety ... patches sold under the brand name Salonpas are approved by the Food and Drug Administration under a New Drug Application (NDA) ... Levy, Sandra (10 December 2001). "External painkillers lead sales in analgesics market". Drug Topics. Retrieved 2010-03-24. ...
Yoo JW, Lee CH (May 2006). "Drug delivery systems for hormone therapy". J Control Release. 112 (1): 1-14. doi:10.1016/j.jconrel ... as well as intrauterine devices More recently developed forms of drug delivery are alleged to have increased local effect lower ... The long-term effects of HRT on most organ systems vary by age and time since the last physiological exposure to hormones, and ... The U.S. Congress did grant the FDA explicit but limited oversight of compounded drugs in a 1997 amendment to the Federal Food ...
... drug delivery systems Pentoxifylline "dextrans". The IUPAC Compendium of Chemical Terminology. 2014. doi:10.1351/ ... As of 2017 several uses for drug delivery had been explored in vitro and a few had been tested in animal models. ... Dextran 70 is on the WHO Model List of Essential Medicines, the most important medications needed in a health system. ...
"Drug delivery from gelatin-based systems. , SpringerLink". Expert Opinion on Drug Delivery. 12 (9): 1547-1563. doi:10.1517/ ... Advanced Drug Delivery Reviews". Advanced Drug Delivery Reviews. Clinical Developments in Drug Delivery Nanotechnology. 60 (8 ... Sripriyalakshmi, S.; Jose, Pinkybel; Ravindran, Aswathy; Anjali, C. H. (September 2014). "Recent trends in drug delivery system ... "Protein-based nanocarriers as promising drug and Gene Delivery Systems. , Journal of Controlled Release". Journal of Controlled ...
... drug delivery systems". Nanoscale. 5 (4): 1273-1283. Bibcode:2013Nanos...5.1273P. doi:10.1039/C2NR32600K. PMID 23166050. ... "Multifunctional Bacteria-Driven Microswimmers for Targeted Active Drug Delivery". ACS Nano. 11 (9): 8910-8923. doi:10.1021/ ... Motile systems have developed in the natural world over time and length scales spanning several orders of magnitude, and have ... Some of the smallest known motile systems are motor proteins, i.e., proteins and protein complexes present in cells that carry ...
Yang, Jia (2021). "Self-Assembled Peptide Drug Delivery Systems". ACS Appl. Bio. Mater. 4 (1): 24-46. doi:10.1021/acsabm. ...
Franklin reorganized the service's accounting system and improved speed of delivery between Philadelphia, New York and Boston. ... Merchants in all thy ports are encouraged by thy laws to continue a commerce whereby so many hundreds of thousands are dragged ... The newly established postal system became the United States Post Office, a system that continues to operate today. From the ... His most notable service in domestic politics was his reform of the postal system, with mail sent out every week. In 1751, ...
The 1985 maximum power allowed by the U.S. Food and Drug Administration (FDA) of 180 milliwatts per square cm is well under the ... A short cervix preterm is associated with a higher risk for premature delivery: At 24 weeks' gestation, a cervix length of less ... When attempting to obtain fetal heart rate with a diagnostic ultrasound system, the AIUM recommends using M-mode at first ... 1996). "The Length of the Cervix and the Risk of spontaneous Premature Delivery". New England Journal of Medicine. 334 (9): 567 ...
The Sun Metro Mass Transit System operates a system of medium- to large-capacity natural gas-powered buses all around the city ... Also headquartered in El Paso are the Drug Enforcement Administration domestic field division 7, El Paso Intelligence Center, ... who hire a manager to carry out its directives and oversee the delivery of public services. The current city manager is Tommy ... As of 2016[update], construction of the system was projected to cost $97 million. In 2019, it was reported that the system is ...
The Huayra's designer Horacio Pagani states that it has a variable drag coefficient of between .31 and .37. The system also ... Upon delivery of the car, Kris Singh was reportedly upset at some small details not being as he specified. Angry at Pagani, he ... The entire system weighs less than 10 kg (22 lb). The Pagani Huayra is different from its predecessor in that it incorporates ... The behavior of the flaps is managed by a dedicated control unit that is fed information from systems such as the ABS and ECU, ...
In 1978, William H. Sanders adapted Froseth's program for delivery using the PLATO IV system. Sanders transferred the slides to ... and Bugs-n-Drugs (a medical variation)-all presaging MUDs (Multi-User Domains) and MOOs (MUDs, Object Oriented) as well as ... the last system that ran the PLATO software system on a CDC Cyber mainframe, from active duty. Existing PLATO-like systems now ... The underlying operating system is NOS 2.8.7, the final release of the NOS operating system, by permission of Syntegra (now ...
... a low-noise air conditioning system has also been fitted. The Class 175 is furnished with a passenger information system, ... After FTPE took delivery of faster Class 185 DMUs, this arrangement ceased during December 2006. During December 2003, all of ... Its launch operator stated that the train possessed both reduced drag and improved fuel efficiency over its existing rolling ... The suspension system involved a dual air-and-spring arrangement that has been claimed to provide a smoother ride than the ...
Intravascular therapeutic Microbot Lab - Microrobot moving controlled through blood vessel for drug delivery and treatment of ... Stem Cell-based Biomedical Microrobot: Mesenchymal stem cell delivery scaffold with magnetic actuating system for articular ... Automatic Grinding Robot system for Metal Faucets : It is an automatic system grinding the sophisticated 3D shape of faucet ... Master and Slave System with force reflection control & image guided surgical robot system) Robotic Couch for Heavy Ion Therapy ...
Additionally, there are no living animals with a delivery system analogous to the proposed system for Euchambersia (most ... Furthermore, grooved and ridged teeth in non-venomous snakes are used to reduce suctional drag when capturing slippery prey ... Mitchell, J.S.; Heckert, A.B.; Sues, H.-D. (2010). "Grooves to tubes: evolution of the venom delivery system in a Late Triassic ... "The comparative method and the inference of venom-delivery systems in fossil mammals". Journal of Vertebrate Paleontology. 27 ( ...
... as well as effectively balancing out induced drag from operating the BLC system. It featured a variable incidence tailplane ... The Buccaneer stood down from its reserve nuclear delivery duties in 1991. The Buccaneer took part in combat operations during ... For redundancy, the Buccaneer featured dual busbars for electrical systems, and three independent hydraulic systems. The ... a self-trimming system was interconnected with the BLC system, and additional blowing of the wing's leading edge was also ...
In civil law systems, similar provisions are usually part of the civil code or criminal code and are often known collectively ... 10709, The Effect of Malpractice Liability on the Delivery of Health Care (August 2004). Daniel P. Kessler & Mark McClellan, ... Supreme Court on Drugs, Medical Laws And Medical Negligence (2014 ed.). EBC. ISBN 9789350288504. Rashidi v. Moser, 339 P.3d 334 ... Medical malpractice#Arguments about the medical liability system GAO-03-702 Medical Malpractice Insurance: Multiple Factors ...
UAVs are emerging as a new way for drug cartels to smuggle illegal drugs into the United States from Mexico. 21 January ... 29 July Aircraft wreckage which appears to be a flaperon - part of the flap system - of a Boeing 777 is found washed up on a ... The last Boeing C-17 Globemaster III, intended for delivery to the United Arab Emirates Air Force in 2017, takes off from the ... Suspected drug traffickers open fire on a patrolling Mexican Navy helicopter as it approaches a group of their vehicles near ...
The healthcare system in Afghanistan is also not at a level to properly care for pregnant mothers. Every two hours there is a ... Some reasons that lead women to pursue abortions to avoid being ostracized include drug and/or alcohol addicted husbands, ... but aid workers are being sent to many regions of the country after receiving training on deliveries and care for newborns. ...
by Harris M. Lentz (Routledge, 2013) p192 Peter Temin, with Louis Galambos, The Fall of the Bell System: A Study in Prices and ... Austria received its first deliveries of natural gas from the Soviet Union with the opening of a pipeline across the ... American drag racer and 2001 NHRA Rookie of the Year; in Houston (killed in accident, 2004) Leah Pinsent, Canadian television ... and Mikhail Ya Marov, Soviet Robots in the Solar System: Mission Technologies and Discoveries (Springer, 2011) pp174-175 From ...
Active management is the administration of a uterotonic drug within one minute of fetal delivery, controlled traction of the ... A scoring system called a Bishop score can be used to judge the degree of cervical ripening in order to predict the timing of ... Early supporters believed that the drugs used during deliveries interfered with "happy childbirth" and could negatively impact ... In some cases twin delivery is done in a larger delivery room or in an operating theatre, in the event of complication e.g. ...
... and Adolescent Mental Health Services Childhood obesity Childhood obesity follow-up 2019 Dentistry Services Drugs policy Drugs ... partnerships and systems inquiry Kark Report Long term funding of adult social care Long-term Sustainability of the NHS ... funding and delivery Suicide prevention Sustainability and Transformation Plans Work of the Secretary of State for Health 2013 ... opened 1 December 2021 Integrated Care Systems: autonomy and accountability, opened 6 July 2022 Independent Medicines and ...
His recent work extended the Biopharmaceutics Classification System, leading to the Biopharmaceutics Drug Disposition ... Career Achievement Award in Oral Drug Delivery (Controlled Release Society, 2004) Paul Ehrlich Magic-Bullet Lifetime ... and transporter-transporter interplay for new molecular entities and drug-drug interactions for already marketed drugs. Benet ... "Effects of Uremic Toxins on Transport and Metabolism of Different Biopharmaceutics Drug Disposition Classification System ...
Royal Columbian was among the better performing hospitals due to its filing systems and regular meetings. A major development ... Royal Columbian Hospital Redevelopment moves forward Chan, Kenneth (29 July 2020). "$259-million mental health, drug abuse ... "PRAISE AND CHARITY AFTER PREMATURE DELIVERY". Royal Columbian Hospital Foundation. 30 January 2017. Retrieved 17 November 2020 ...
... ultrasound contrast agents can be turned into drug delivery vehicles, so that we can try and combine measurement with treatment ... Hall's research "is focused on understanding how biology can be interfaced with electronic, mechanical and optical systems to ... Sometimes, we find that we can use our knowledge to make hybrid systems: for example, ... as well as other measure environment from the molecular level to a whole system (living or abiotic). She has a special interest ...
The whole international drug control system envisages in its penal provisions the illicit traffic in drugs; this also holds ... delivery on any terms whatsoever, brokerage, dispatch, dispatch in transit, transport, importation and exportation of drugs ... drugs) Drug policy Illegal drugs trade War on drugs: Mexican drug war; Philippine drug war; Plan Colombia "Single Convention on ... Drugs in Schedule II are regulated only slightly less strictly than Schedule I drugs. The Commentary confirms, "Drugs in ...
Antiviral drugs, cidofovir and tecovirimat, vaccinia immune globulin and the smallpox vaccine may be used during outbreaks. The ... Cases may be severe, especially in children, pregnant women or people with suppressed immune systems. The disease is caused by ... for delivery in 2023 and 2024. Should the second option be exercised, it would work out to approximately 13 million doses. ... Better understanding of the new monkeypox variant is important for accelerating the development of vaccines and drugs. The UK ...
Whitehead KA, Dahlman JE, Langer RS, Anderson DG (2011). "Silencing or stimulation? siRNA delivery and the immune system". ... These PEGylated drugs are injected once weekly, rather than administering two or three times per week, as is necessary for ... "System-level comparison of protein-protein interactions between viruses and the human type I interferon system network". ... Both hepatitis B and hepatitis C are treated with IFN-α, often in combination with other antiviral drugs. Some of those treated ...
This novel structure system has inspired ongoing research in nanotechnology, drug delivery, and therapeutics. In nature, the ... "Stable RNA nanoparticles as potential new generation drugs for cancer therapy". Advanced Drug Delivery Reviews. 66: 74-89. doi: ... Φ29's DNA packaging system, using pRNA, incorporates a motor for the delivery of therapeutic molecules like ribozymes and ... The three-way junction in the Φ29 DNA packaging motor can help sensitize TNBC cells to chemotherapy using a siRNA drug delivery ...
The program provides 350 impoverished families with two monthly deliveries of nutritious food. Participating families are ... styling and make-up groups for former drug addicted women, and many others, all designed to empower these marginalized women ... Teenage Girls assistgirls who engage in destructive behaviors and are at great risk of falling through the gaps in the system ...
Multibase delivery for long reads in sequencing by synthesis protocols, (2012). Methods and systems for detecting genetic ... The Food and Drug Administration granted Guardant360 Expedited Access Pathway status in 2018. GuardantOMNI, an expanded testing ... Eltoukhy's doctoral thesis, "An integrated system for de novo DNA sequencing" research was completed in the laboratory of Abbas ... "Guardant Health to Develop Blood-Based CDx for AstraZeneca Drugs". GenomeWeb. 13 Dec 2018. Retrieved 10 Nov 2019 ...
It is managed by life prolonging drugs known as Antiretroviral drugs (ARVs). TB was discovered by Robert Koch in 1882. It is ... Malnutrition, the immune system, and infectious diseases operate in a cyclical manner: infectious diseases have deleterious ... infection is one of special concern because it is associated with a heightened risk for contracting HIV and pre-term deliveries ... Of 1393 new drugs brought into use over a period of 25 years (1975-1999), only a total of thirteen, less than 1%, related to ...
Others have a much more pluralistic delivery system, based on obligatory health with contributory insurance rates related to ... at which time coverage was extended to include drugs and sickness compensation, as well. Kuhnle, Stein; Hort, Sven E.O. ( ... Almost all European systems are financed through a mix of public and private contributions. Most universal health care systems ... "OECD Reviews of Health Systems OECD Reviews of Health Systems: Russian Federation 2012": 38. {{cite journal}}: Cite journal ...
Sedan Deliveries by the Dozens, Collectible Automobile, vol. 15, no. 6, pp. 86-89. Doty, Dennis. 2000a. Shades of Difference, ... The cars came in boxes brightly colored in the "Rapid Transit System" graphics of that time when cars were actively marketed to ... Examples include Dick Branstner's 'Little Red Truck' (based quite broadly on his 'Color Me Gone' Dodge Truck); the Super Drag ... One difference between the Coronet promo and contemporary AMT products was that MPC exhaust systems and rear suspension parts ...
Nottingham study will look at how to boost COVID vaccination protection in people with suppressed immune systems due to drugs; ... "Petrol deliveries: Supply remains critical in south-east England, say retailers". BBC News. 2 October 2021. Retrieved 2 October ... Ronapreve, a drug that uses a pair of laboratory created COVID antibodies to treat the virus, is approved for use in the UK. It ... The anti-COVID drug Paxlovid, which can cut hospitalisation in vulnerable people by as much as 89%, is approved for use in the ...
... and a fuel delivery system with two sources. He developed dynamometer testing for nitromethane. Some innovations later outlawed ... He began drag racing in NHRA's Northwest division in a Chevrolet Z-11 in the B/Factory Experimental class in a front-ended ... In 1957, he began drag racing the car on a dragstrip at an airport near Calgary. It took him five attempts to make a 60-mile- ... In 2001, the NHRA ranked him tenth on their Top Fifty drag racers of all time. He was inducted into the Motorsports Hall of ...
USAF weapon systems officer Captain Jeffrey Feinstein became the fifth and last U.S. ace of the war when he and his pilot shot ... The move was seen as an effort by the PAVN to match U.S. equipment deliveries before any ceasefire in place. North Vietnam ... Sylvan Fox (17 December 1972). "Drug feared sent in bodies of G.I.s". The New York Times. p. 21. "Saigon reporting an enemy ... The team consisted of two UH-1B helicopters each mounting the XM26 TOW weapons system.: 215 Da Nang Air Base was hit by PAVN ...
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X ...
An advanced mode of drug delivery system has been developed to overcome the major drawbacks associated with conventional drug ... of drug delivery system has been developed to overcome the major drawbacks associated with conventional drug delivery systems. ... As a drug delivery system they enhance the therapeutic efficacy of the drug and minimize adverse effect and toxic reactions. ... Pouton CW (1997) Formulation of selfemulsifying drug delivery systems. Adv Drug Deliv Rev 25:47-58 ...
Action programme on essential drugs and vacines: progress report by the Executive Board Ad Hoc Committee on Drug Policies  ... Action Programme on Essential Drugs: progress report by the Director-General submitted to the Committee on Drug Policies  ... Action Programme on Essential Drugs: orientation document for programme review  Executive Board, 95 (‎World Health ... Action programme on essential drugs and vacines (‎draft resolution proposed by the chairman of the ad hoc committee and the ...
MIT develops new jet injection system for drug delivery. .legacy #content.article .image-holder # ... The device is small, but powerful magnet surrounded by a coil of wire with a piston attached inside the drug ampoule. The ... The researchers are developing a version of the device for delivering drugs found in a powdered form. In this instance, the ... That is a significant improvement over jet injection systems that are available right now. Different medications have to be ...
Special Issue in Pharmaceutics: Additive Manufacturing Approaches to Produce Drug Delivery Systems Volume II. Special Issue in ... Special Issue in Pharmaceutics: Additive Manufacturing Approaches to Produce Drug Delivery Systems Volume II. Special Issue in ... Editorial for Special Issue: "Additive Manufacturing Approaches to Produce Drug Delivery Systems" by Joana F. A. Valente ... Here, we have explored whether it can be used as a controlled local delivery system for antibiotic drugs. An easy loading ...
... *. ... ABBOTT VASCULAR XIENCE ALPINE DRUG ELUTING CORONARY STENT DELIVERY SYSTEM Back to Search Results. ... U.S. Food and Drug Administration. 10903 New Hampshire Avenue Silver Spring, MD 20993 Ph. 1-888-INFO-FDA (1-888-463-6332). ...
"Synthesis and Biological Activity of Drug Delivery System Based on Chitosan Nanocapsules" written by Mohamed Gouda, Usama ... Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery. Pharmaceutics, 2019. DOI: ... Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery ...
Drug development technology in Pharmaceutical Industry with innovations in formulation development have recei ... Current Status of Drug Delivery Systems During the past two decades, ... Particulate Oral Drug Delivery System In any drug delivery system the use of carriers to convey a certain dose of the drug is ... context controlled drug delivery along with targeted drug delivery forms the essence of modern and future drug delivery systems ...
Chlorambucil-Iron Oxide Nanoparticles as a Drug Delivery System for Leukemia Cancer Cells ... Polymer-lipid hybrid nanoparticles: a novel drug delivery system for enhancing the activity of Psoralen against breast cancer. ... Chlorambucil-Iron Oxide Nanoparticles as a Drug Delivery System for Leukemia Cancer Cells ... Chloramb-CS-IONPs nanocomposite is biocompatible with normal cells and would be very useful for use as a drug delivery system. ...
Persons tagged with «Drug delivery systems». Name. Phone. E-mail. Tags. Zaytseva-Zotova, Daria Postdoctoral Fellow +47 45381833 ... Biomaterials, 3D cell culture, Drug delivery systems, Hydrogels, Natural polymers, Biomaterials, Cell-biomaterial interactions ...
Give aerosol drug easily and accurately for asthma and respiratory distress *No break in airway circuit; no lost drug if ... Resuscitator and Rapid Drug Delivery System  ... Immediate medicine delivery in emergency situations *All ... Administer drug therapy without disconnecting resuscitator from ET Tube * ...
For reconstitution of powdered drug with a diluent prefilled syringe. ... Drug Reconstitution device enables the easy preparation of lyophilized drugs. ... The system is a single unit for reconstituting a powder drug with a diluent prefilled syringe. Upon reconstitution, the drug is ... Lyophilized drugs supplied with prefilled diluent syringes. Information herein is for use only in countries with applicable ...
Talks were on the areas related to scaling up of controlled delivery systems, drug eluting stents, leveraging drug delivery ... Seminar on "Controlled Release Drug Delivery Systems: Scale up, Commercialization and Entrepreneurship Opportunities" *AICTE- ... One-day seminar on "Controlled Release Drug Delivery Systems: Scale up, commercialization and Entrepreneurship Opportunities" ... Seminar on "Controlled Release Drug Delivery Systems: Scale up, Commercialization and Entrepreneurship Opportunities" ...
HYMADE focuses on the development of capsules and engineered colloidal particles for drug delivery combining mesoporous ... drug release, degradation and therapeutical efficiency of the drug delivery systems will be studied in vitro and in vivo with ... Hybrid Drug Delivery Systems upon Mesoporous Materials, Self Assembled Therapeutics and Virosomes. ... HYMADE aims to profit from the combination of hybrid materials to fabricate advanced drug delivery systems with controlled ...
Novel Drug Delivery Systems Market Research Report by Route of Administration, Mode, End-User, Region - Global Forecast to 2027 ... Novel Drug Delivery Systems Market Research Report by Route of Administration, Mode, End-User, State - United States Forecast ... Europe Novel Drug Delivery System (NDDS) Market - Growth, Trends, and Forecasts (2020 - 2025) * Report ... North America Drug Delivery Systems Market to 2027 - Regional Analysis and Forecasts by Route of Administration; Distribution ...
Improved efficacy and dosing convenience are the aims of a new drug delivery system incorporating a cationic polymer and ... It incorporates a cationic polymer to achieve sustained and enhanced ocular delivery of drugs. Both the original system and its ... Improved efficacy and dosing convenience are the aims of a new drug delivery system incorporating a cationic polymer and ... New drug delivery system aims to increase tissue penetration. .social-ris-container { display: flex; justify-content: space- ...
The purpose of this research was to develop the pseudo-ternary phase diagrams for a model drug delivery system consisting of ... phenomenon of phase inversion from W/O microemulsion to O/W microemulsion was also investigated for the drug delivery system ... Ziheng Wang (2009). PSEUDO-TERNARY PHASE DIAGRAMS OF A DRUG DELIVERY SYSTEM. UWSpace. ... The model drug (vitamin E) was loaded in the oil phase. The effects of different surfactants (pure and mixed) on the phase ...
Injectable and Needle-Free Delivery Systems With pharmaceutical companies increasingly looking for ways to extend the revenue- ... Table The Worldwide Market for Injectable/Implantable Drug Delivery Systems by Pharmaceutical and Drug Delivery Component 2003- ... Kaloramas Drug Delivery Markets: Implantable / Injectable and Needle-Free Delivery Systems provides detail for business ... Drug Delivery Markets: Implantable / Injectable and Needle-Free Delivery Systems. Lowest Prices Guaranteed. Length. Publisher. ...
is Signing a Strategic Agreement to Provide Drug Delivery Systems to ICAHRIS in Canada. Strategic agreement for the development ... The center has expertise in medicine, advanced nanoparticle development, targeted delivery systems for drugs and biologics, and ...
Twenty-four counties have now been approved to deliver services through the Drug Medi-Cal Organized Delivery System Waiver, ... We provide the leadership, advocacy, training and tools that empower Californias hospitals and health systems to do their best ...
... and systems for transporting a pharmaceutical compound within the body some time suppor.. ... Drug Delivery Systems. Drug delivery refers to approaches, formulations, technologies, and systems for transporting a ... its generally involved with each amount and duration of drug presence. Drug delivery is usually approached via a drugs ... Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the advantage of improving ...
Design and synthesis of new s-triazine polymers and their application as nanoparticulate drug delivery systems† ... Design and synthesis of new s-triazine polymers and their application as nanoparticulate drug delivery systems S. N. Khattab, S ... The feasibility of the synthesized polymers as drug nanodelivery systems was investigated. The nanoparticles were loaded with ... with good drug loading in the range 1.58-4.19%. After 48 h, 46.90, 64.20, 57.81, 53.95, and 49.43% of CXB was released from ...
As for drug delivery system, Chapter 4 and Chapter 5 focus on the development of biocompatible microgels-based systems for ... the cell scaffold and the drug delivery system. As for the cell scaffold, it can be realized by colloidal supra-structure ... gel shell can trigger the drug release by local temperature change, offering sustained drug release profiles. In Chapter 5, ... The constructed colloidal supra-structure can be regarded as a model system for a new class of cell scaffolds. ...
The reviews are at the cutting edge of the science underpinning drug discovery, written by experts in their respective fields ... The journal covers the whole of the preclinical drug discovery process, from target identification and validation, through hit ... through the most innovative computational approaches drug design, the science driving medicinal chemistry and the translation ... and cover all aspects of drug discovery from state-of-the-art genomic and proteomic approaches to target identification, ...
Advanced BBB drug delivery technologies essentially produce central nervous system (CNS) drugs that can pass the BBB using a ... Advantages of advanced drug delivery systems over traditional systems are more convenient routes of administration, greater ... GLOBAL DELIVERY MARKET - Advanced Drug Delivery Systems: mAb, RNAi, & Breaking the Blood-Brain Barrier. ... A significant challenge for both drug and drug delivery companies is to produce existing and emerging drug technologies in a ...
Studies investigating the preparation of solid core drug delivery systems for oral delivery of γ-globulin via supercritical ... Solid core drug delivery systems (SCDDS) allow for immobilization of these molecules on a solid surface to improve and maintain ... The aim of this research was to develop a SCDDS for the oral delivery of peptide/protein-based drugs, using inorganic/organic ... protein therapeutics has led to the growing research in the development of novel carrier systems particularly for oral delivery ...
In addition, introduction of a novel drug delivery systems in CNS also offers ample growth opportunities to the central nervous ... Insights on the Central Nervous Disorders Therapeutics Global Market to 2030 - Introduction of a Novel Drug Delivery Systems in ... The central nervous system (CNS) is a complex system that regulates and coordinates body activities. Central nervous system ( ... Furthermore, increase in prevalence of CNS disorders and presence of strong pipeline drugs are some of the factors, which are ...
The studied systems exhibited fine-tuned sustained release features, which may provide a continuous delivery of the drug at ... Validation of smart nanoparticles as controlled drug delivery systems: loading and pH-dependent release of pilocarpine. ... Hence, the studied NPs proved to behave as smart controlled drug delivery systems capable of responding to changes in pH. ... Micelles are good devices for use as controlled drug delivery systems because they exhibit the ability to protect the ...
  • Toward this goal, novel iron oxide nanoparticles (IONPs) coupled with leukemia anti-cancer drug were prepared and assessed. (
  • Drug delivery refers to approaches, formulations, technologies , and systems for transporting a pharmaceutical compound within the body some time supported nanoparticles as needed to soundly achieve its desired therapeutic effect. (
  • In Chapter 5, additionally embedded of magnetic Fe3O4 nanoparticles enable such hybrid nanogels to delivery pharmaceuticals to a specific site of the body by applying a gradient magnetic field. (
  • Additionally, the introduction of fluorescent Ag nanoparticles (NPs) to the microgels can realize the integration of optical glucose detection and self-regulated insulin delivery into a single nano-object. (
  • The present work assesses loading kinetics of a hydrophobic drug, pilocarpine, in polymeric micellar nanoparticles (NPs) and its pH-dependent release in hydrophilic environments. (
  • Nanoparticles are currently being used as carriers to deliver drugs to the tumor site. (
  • To circumvent these challenges, a wide range of synthetic delivery vectors ( liposomes , lipid nanoparticles , polymer micelles, inorganic nanoparticles, dendrimers, etc.) have been developed over the past few decades, some of which have been clinically approved. (
  • We herein construct an efficient cell-targeting drug delivery system (Sgc8-MSN/Dox) based on aptamer-modified mesoporous silica nanoparticles that relies on the tumor-targeting ability of the aptamer Sgc8 to deliver doxorubicin (Dox) to leukemia cells in a targeted way, thereby improving therapeutic efficacy and reducing toxicity. (
  • The resulting Sgc8-MSN/Dox showed good morphology and size for drug delivery, and the nanoparticles were taken up selectively by leukemia cells in culture, leading to effective killing of tumor cells. (
  • The purpose of this study is to try to reveal that aptamer-modified meso porous silica nanoparticles can not only target the diagnosis of tumors, but also kill tumors by loading drugs, so as to provide ideas for tumor-targeting theranostics. (
  • Schematic illustration of Sgc8 aptamer-modified mesoporous silica nanoparticles for an efficient cell-targeting drug delivery system. (
  • To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. (
  • 2018) Ultrasound mediated delivery of enzyme sensitive nanoparticles in human prostate cancer xenografts. (
  • 2016) Ultrasound-mediated delivery of novel bio-responsive nanoparticles. (
  • To date, we have worked with a wide variety of nanotherapeutics from lipidic nanoparticles to polymeric and from virosomes to exosomes for the delivery of diagnostics, small molecules, biopharmaceuticals, biopolymers and nucleic acids. (
  • Interaction of nanomaterials with the human immunological & haematological systems , pathways of cellular uptake of nanoparticles (both receptor and non-receptor mediated), nanotoxicity of nanomaterials and interaction of nanoparticles with plasma proteins (biomolecular corona). (
  • The definition of dose for nanoparticles in an in vitro system is particles in vitro. (
  • Scientific technology company Renishaw is being supported by the Horizon 2020 programme for its trials of a new drug delivery system aiming to help treat Parkinson's disease. (
  • The global microneedle drug delivery systems market is estimated to garner a revenue of ~USD 1300 million by the end of 2035 by growing at a CAGR of ~7% over the forecast period, i.e., 2023 - 2035. (
  • The global microneedle drug delivery systems market is also estimated to witness growth on account of the rising number of minimally invasive cosmetic surgery procedures worldwide. (
  • Growth of the Healthcare Industry - microneedle drug delivery systems offer various advantages compared to conventional hypodermic injections such as enhanced efficacy, self-administration, and quick onset of action. (
  • The increasing research and development by large firms and business organizations in microneedles to improve their stability is estimated to fuel the growth of the microneedle drug delivery systems market in the coming years. (
  • Transdermal drug delivery systems (TDDSs) are discrete dosage forms that are designed to deliver therapeutically effective amount of drug through intact skin to the systemic circulation. (
  • The objective of the course is to provide knowledge and understanding of skin physiology, topical and transdermal drug delivery systems, formulations and manufacturing technologies, excipients in use, different strategies for skin penetration enhancing and analytical method for skin penetration determination. (
  • Skin tolerability associated with transdermal drug delivery systems: an overview. (
  • First it involves transport of the drug to particular part of the body and the second function is that of the controlled release. (
  • For controlled release systems, the oral route has by far received most attention and success because of the fact that gastro-intestinal physiology offers more flexibility in dosage form design than other routes 6 . (
  • The release of the drug from the nanocomposite was found to be of a controlled-release manner with around 89.9% of the drug was released within about 5000 min and governed by the pseudo-second order. (
  • One-day seminar on "Controlled Release Drug Delivery Systems: Scale up, commercialization and Entrepreneurship Opportunities" was organized by CRS-Indian Local Chapter, Mumbai and Manipal Academy of Higher Education [MU] at Bengaluru Campus, Manipal Academy of Banking, Bengaluru on 5 December 2015. (
  • Talks were on the areas related to scaling up of controlled delivery systems, drug eluting stents, leveraging drug delivery strategies to drive innovation, different controlled release dosage forms, hot melt extrusion technology, etc. (
  • HYMADE aims to profit from the combination of hybrid materials to fabricate advanced drug delivery systems with controlled release and targeting efficiency of biological entities. (
  • With the development of technology, controlled release technologies are now able to achieve not only slow release of drugs, but also more precise and intelligent regulation of the space, time and release profile of drugs. (
  • The aim of this chapter is to review the literature for SMART nanocarrier-based delivery systems and extended controlled release DDSs which maintain the concentration of the drug within the therapeutic window for a longer time, thereby lowering the frequency of administration. (
  • Polymers, such as pegylated drugs, have essayed a crucial part in the progress of drug delivery technology by creating opportunities for controlled release of therapeutic drugs in continual doses over a long duration of time. (
  • Nanoemulsions are nano-sized emulsions, which are manufactured for improving the delivery of active pharmaceutical ingredients. (
  • During the past two decades, Drug development technology in Pharmaceutical Industry with innovations in formulation development have received a lot of attention. (
  • West products promote the efficiency, reliability and safety of the world's pharmaceutical drug supply. (
  • With pharmaceutical companies increasingly looking for ways to extend the revenue-earning lifetime of their biggest products, drug delivery has become an important focus of the industry. (
  • Product developer Antares Pharma and Teva Pharmaceutical announced recently a new needle-free injector system called Tjet used to administer the growth hormone product Tev-Tropin to children. (
  • Indeed, research-based pharmaceutical companies are continuously working toward the discovery and development of new drug delivery systems. (
  • Transdermal technologies alone have opened new doors for pharmaceutical partners seeking to create delivery mechanisms for existing molecules with no viable delivery system and existing drugs that could benefit from additional delivery systems, such as compounds that were previously unable to be delivered through the skin. (
  • Having evolved from a producer of pharmaceutical glass to a full solution provider, Stevanato Group understands how a pharmaceutical product, container, closure and drug delivery device interact with each other and work together to form a cohesive system. (
  • In order to evaluate the feasibility of the microwave crosslinking process for pharmaceutical applications, both the drug loading and the drug release processes were evaluated using diclofenac as drug model, either as acidic form or as sodium salt. (
  • Evonik provides pharmaceutical and biotechnology companies with a strong portfolio of functional polymers , proprietary technologies and formulation expertise to enable and enhance colon targeted drug delivery for oral solid dosage forms. (
  • Furthermore, I learned about regulations in the pharmaceutical industry, good manufacturing practice (GMP), and tests that are required to bring a drug to market. (
  • The ongoing trend of the pharmaceutical industry is shifting toward pre-filled syringes (PFS) as the optimal delivery system for many drug products. (
  • His interests include drug delivery and targeting, nanomedicine, multifunctional and stimuli-sensitive pharmaceutical nanocarriers, biomedical polymers, experimental cancer therapy. (
  • He is Editor-in-Chief of Current Drug Discovery Technologies, Drug Delivery, and OpenNano, Co-Editor of Current Pharmaceutical Biotechnology and on the Editorial Boards of many other journals. (
  • The project also aims to gain understanding of the self assembly process of hybrid materials and the transport properties of the drug delivery systems.The biological fate, drug release, degradation and therapeutical efficiency of the drug delivery systems will be studied in vitro and in vivo with state of the art imaging techniques. (
  • However, several physicochemical and biological barriers pose as a challenge for the use of biomolecules as oral drug therapies. (
  • One factor to consider in Drug Delivery System (DDS) development is drug encapsulation efficiency, since exosomes are biological products derived from cellular activity, they have less freedom to adapt to their lipid membranes and internal composition compared to liposomal delivery systems. (
  • Design, synthesis, & biological evaluation of nanoparticle drug delivery systems. (
  • The sound waves can be applied from outside the head to target an area where epileptic seizures can start, and will release the drug from tiny biological packages circulating in the blood stream as they pass through the area, to suppress the seizure activity," he says. (
  • Noticing SPM fixation varieties over a continuum of spatiotemporal scales, from a couple of meters to a few kilometers, and from hours to years, works on how we might interpret the design and working of near shore marine biological systems. (
  • In any case, the improvement of calculations explicitly adjusted to turbid waters is a significant necessity for hydroponics the executives and shellfish biological systems studies since clam cultivating destinations are regularly situated inside sloppy intertidal conditions described by significant and exceptionally factor SPM focuses. (
  • In Biomechanics, engineering principles taken from the traditional disciplines of mechanics and materials are applied to biological systems, with applications in biology, biotechnology and medicine. (
  • We are utilising a number of approaches to understand how nanomaterials interact with biological systems. (
  • In the three-arm preclinical pharmacokinetic study, formulations of ketorolac with the new system achieved a concentration in the aqueous humor of the eye of more than two and four times that of ketorolac with the older system or ketorolac alone, respectively. (
  • A few review articles have focused on clinical findings and pharmacogenetics of NTX, advantages and limitations of sustained release systems as well as pharmacological studies of NTX depot formulations for the treatment of alcohol and opioid dependency. (
  • Conventional formulations are associated with poor drug solubility, toxic side effects, lack of site selectivity, uncontrollable release profile, and low bioavailability. (
  • This multi-layer combination creates a range of formulation opportunities to improve drug efficacy, including the creation of once daily dosing formulations, the reduction of the total dose, and more constant plasma concentrations. (
  • Compared with conventional drug formulations, hydrogels are able to be administered intraoperatively and directly release the entrapped therapeutic agents to the unresectable tumor sites. (
  • Among all the formulations F7 formulation showed maximum % drug release i.e., 98.62% in 60 min hence it is considered as optimized formulation. (
  • Drug delivery is usually approached via a drug's chemical formulation, however it's going to additionally involve medical devices or drug-device combination merchandise . (
  • Customers can source their glass primary packaging, assess their formulation stability through analytical testing services, select one of the many proprietary drug delivery devices or even develop a new breakthrough device, and have their combination product manufactured to the highest standard using state-of-the-art injection moulding and automated assembly equipment with integrated inspection technologies. (
  • It is non-toxic, biodegradable, biocompatible, and acts as a bioadhesive with otherwise unstable biomolecules - making it a valuable component in the formulation of biopharmaceutical drugs. (
  • Chitosan-Based Systems for Biopharmaceuticals is an important compendium of fundamental concepts, practical tools and applications of chitosan-based biopharmaceuticals for researchers in academia and industry working in drug formulation and delivery, biopharmaceuticals, medicinal chemistry, pharmacy, bioengineering and new materials development. (
  • Wilmington, Delaware, United States, Sept. 29, 2022 (GLOBE NEWSWIRE) -- Transparency Market Research Inc. - In 2021, the value of global smart drug delivery systems market size was clocked at US$ 8.7 Bn. (
  • The growth rate of smart drug delivery systems market is estimated to be 15.2% CAGR during the forecast period, from 2022 to 2031. (
  • Chiavacci R (2022) The Impact of Drug and Alcohol Intoxication on Glasgow Coma Scale Assessment. (
  • The Biojector 2000 is a popular system for vaccine delivery, the SeroJet has been used for delivering hormone treatments for HIV-associated wasting, and the PenJet has been used for multiple applications. (
  • The report features an extensive study of the current landscape and the likely future opportunities associated with novel vaccine delivery devices, over the next 10-12 years. (
  • A detailed assessment of the overall novel vaccine delivery devices market landscape, featuring an elaborate list of device developers engaged in the development of novel vaccine delivery devices. (
  • A detailed competitiveness analysis of novel vaccine delivery devices, taking into consideration the supplier power and key product specifications. (
  • A detailed list of marketed and pipeline vaccine candidates that are anticipated to be developed in combination with novel vaccine delivery devices in the near future. (
  • Elaborate profiles of prominent product developers engaged in the novel vaccine delivery devices domain ( shortlisted on the basis of the number of pipeline products ). (
  • The as-prepared IONPs were found to be magnetite (Fe 3 O 4 ) and were coated by the CS polymer/Chloramb drug for the formation of the Chloramb-CS-IONPs. (
  • Improved efficacy and dosing convenience are the aims of a new drug delivery system incorporating a cationic polymer and formulated with ketorolac. (
  • It incorporates a cationic polymer to achieve sustained and enhanced ocular delivery of drugs. (
  • A previous paper dealt with the preparation of an in vitro programmable zero-order drug delivery system in which the area of the surface exposed to the dissolution medium and the macromolecular relaxation of polymer controlled the release of the drug. (
  • The results indicate that the synchronization of the movement of swelling and eroding fronts at the solvent-system interface determines the achievement of the linear-release kinetics of such swelling activated systems and that the swelling and dissolution characteristics of the polymer employed for core preparation govern front movement. (
  • The proprietary system consists of an outer layer of an enteric polymer and an inner layer of a sustained release polymer. (
  • The dual-layer colon targeted drug delivery system consists of an outer layer of a pH-dependent soluble coating for enteric protection and colon targeting such as EUDRAGIT® FS 30 D, and an inner layer coating of a sustained release polymer such as EUDRAGIT® RL or EUDRAGIT® RS. (
  • Nanoemulsions are a colloidal particulate system in the submicron size range acting as carriers of drug molecules. (
  • A number of drug delivery platform technologies currently exist that may be adapted to various drug molecules to yield superior medicines. (
  • Solid core drug delivery systems (SCDDS) allow for immobilization of these molecules on a solid surface to improve and maintain their stability, followed by the enteric coating to achieve targeted/sustained release. (
  • On the other hand, electrostatic interactions between the adsorbent surface and the adsorbing molecules were suggested to largely influence y-globulin immobilization on PCL-ES100 systems. (
  • C. Drug delivery potential of exosomes: Exosomes can be used to deliver a variety of drugs such as RNA, proteins, and small molecules. (
  • During my PhD, my research work was focused on improving the drug delivery of hydrophobic drugs using carrier molecules such as polymeric micelles and surface active ionic liquid mixed micelles. (
  • Kalorama's Drug Delivery Markets: Implantable / Injectable and Needle-Free Delivery Systems provides detail for business planners on the market for implantable / injectable delivery system markets. (
  • Kalorama's trusted information-gathering process provides most accurate study of the implantable/injectable delivery drug market available today. (
  • In its report Drug Delivery Markets: Implantable / Injectable and Needle-Free Systems, Kalorama says a recent convergence of synthetic materials and computerized design software will propel the market for such product delivery systems to 9.7% annual growth over the next five years. (
  • More information on needle-free systems can be found in Kalorama Information's new report Drug Delivery Markets: Implantable / Injectable and Needle-Free Systems, which provides an in-depth breakdown of the global market for these devices. (
  • In this review, we summarize the latest clinical data on commercially available injectable and implantable NTX-sustained release systems and discuss their safety and tolerability aspects. (
  • Presently, there are many smart versions of medication inhalers , handheld / wearable injectors , drug delivery pumps, and implantable devices, in the market. (
  • In terms of delivery mode, in 2021, the injectable category commanded a sizeable market share owing to the advantages of injections, which include lower dosage frequency, simplicity in use, improved patient compliance, and less discomfort. (
  • The application of modern technology in the field of drugs administered via oral, parenteral, pulmonary and intra-ocular finds a newer, better than the conventional dosage forms is an important era in the drug delivery. (
  • Hydrophobic drugs can be dissolved in these systems, enabling them to be administered as a unit dosage form for per-oral administration. (
  • The field of nanomedicine employs novel drug delivery systems (NDDSs) to overcome the limitations of traditional dosage forms. (
  • Antibody levels are also a factor when calculating the dosage of therapeutic drugs. (
  • The rising interest in protein therapeutics has led to the growing research in the development of novel carrier systems particularly for oral delivery. (
  • Over the years, central nervous disorders therapeutics market has shown huge growth due to advancements in diagnostics, treatment, and drug discovery techniques. (
  • In addition, introduction of a novel drug delivery systems in CNS also offers ample growth opportunities to the central nervous disorders therapeutics market. (
  • Innovative drug delivery technologies can aid drug manufacturers to improve patent protection, to distinguish between novel therapeutics and existing ones. (
  • These can come in the form of the use of nasal delivery systems for vaccines, drug patches, or oral medications. (
  • Beginning December 1, 2018 , the National Institute for Occupational Safety and Health (NIOSH) will accept applications to implement the coordinated regulatory process to exempt a subset of filtering facepiece respirators (FFRs) from Food & Drug Administration (FDA) premarket notification requirements. (
  • Current data from both the International Safety Center Exposure Prevention Information Network (EPINet®)(2019) and the Massachusetts Department of Public Health Sharps Injury Surveillance System (2018) collected from U.S. hospitals, show that the devices most frequently involved in sharps injuries are disposable hypodermic syringes (19.5 and 34% respectively) and suture needles (22% in each system). (
  • Cannabis is the most widely used illicit drug in the U.S. In 2018, 16% of Americans aged 12 years or older reported using cannabis. (
  • The project comprised the analysis of the effectiveness of polymeric nanocarriers for the delivery of hydrophobic drugs. (
  • Synthesis and characterization of highly surface active ionic liquids and their mixed micellization behavior with different amphiphilic block copolymers for the solubilization of hydrophobic drugs. (
  • A novel smart nanoparticle-based system has been developed for tracking intracellular drug delivery through surface-enhanced Raman scattering (SERS). (
  • The market for smart drug delivery systems was led by North America in 2021, and this dominance is anticipated to continue throughout the forecast period. (
  • 2021) Ultrasound and microbubble treatment for improved delivery of nanomedicine to tumours and the brain. (
  • Hydrogels , as novel local drug delivery systems , presented excellent biocompatibility, high drug loading capacity and sustained drug release property. (
  • With the first oral drug product utilizing EUDRATEC® COL having reached the market in 2017, the technology represents a reliable and commercially proven system to enable colon targeted drug delivery. (
  • The expected action date by the FDA under the Prescription Drug User Fee Act (PDUFA) is May 29, 2017. (
  • Drug delivery may be a thought heavily integrated with dose kind and route of administration, the latter typically even being thought of a part of the definition. (
  • Drug delivery system (DDS) is a technology system that comprehensively regulates the distribution of drugs in organisms in space, time and dose. (
  • Smart drugs would be able to deliver the most accurately therapeutic dose of medication. (
  • On the heels of the Food and Drug Administration's emergency use authorization of a third dose - or "booster shot" - of the Pfizer-BioNtech vaccine for certain Americans, on Oct. 20, the agency also gave emergency authorization to a third Moderna shot and a second dose of the Johnson & Johnson vaccine . (
  • A dose form that is an assembly of components for transdermal delivery driven by external forces. (
  • 2005), delivery are accounted for, trends and magnitude of the cellular dose little attention has been devoted to a critical examination of their as a function of particle size and density differ significantly from those implied by ``concentration'' doses. (
  • HYMADE focuses on the development of capsules and engineered colloidal particles for drug delivery combining mesoporous colloids, the Layer by Layer (LbL) technique and virosomes. (
  • The constructed colloidal supra-structure can be regarded as a model system for a new class of cell scaffolds. (
  • The zeta potential (ZP) of colloidal systems and nano-medicines, as well as their particle size exert a major effect on the various properties of nano-drug delivery systems. (
  • Due to the similarity between liposomes and exosomes, physicochemical properties and drug delivery capabilities of the two will be compared next. (
  • hydrophilic drugs can be loaded in the lumen of liposomes. (
  • A device would be connected to the head of the patient, and drug-containing liposomes - a drug delivery vehicle - will be injected into the blood stream. (
  • 2019) Intratumoral microdistribution and therapeutic response of enzyme sensitive liposomes in human prostate cancer xenografts after ultrasound mediated delivery. (
  • Increase in the incidence of chronic diseases and growing patient demand for advanced drug delivery systems is projected to fuel growth of smart drug delivery systems market. (
  • The health scenario in India demands Novel Drug Delivery Systems (NDDS) for more than 20 diseases and conditions for which rationale for such system is established. (
  • Although the drug delivery concept is not new, a great progress has recently been done in the treatment of variety of diseases. (
  • Leukemia is one of the hematologic malignancies diseases which is most common in adults which affects the bone marrow, lymphatic system and blood cells. (
  • These factors, along with new developments in targeted drug delivery, are aiding localized treatment of diseases with minimized harm to healthy surrounding cells. (
  • Central nervous system (CNS) disorders, also known as central nervous system diseases. (
  • Accordingly, EUDRATEC® COL can help to enable and enhance the localized treatment of colonic diseases such as Inflammatory Bowel Disease or colon cancer, as well as the systemic delivery for sensitive APIs where absorption in the colon is desirable. (
  • Increase in global prevalence of chronic diseases that require novel drug delivery technologies for treatment is expected to boost the market. (
  • The team, from Eindhoven University of Technology in the Netherlands, believes this new method will lead to the development of smart drugs that more effectively treat autoimmune diseases like rheumatoid arthritis and Crohn's disease. (
  • 2019) Ultrasound-mediated delivery of nanomedicine for improved treatment of cancer and brain diseases. (
  • Drug delivery as an opportunity to extend product life cycles has indeed proved its place in the market with significant advantages of therapeutic gains as well as commercial success. (
  • Advantages of advanced drug delivery systems over traditional systems are more convenient routes of administration, greater efficacy and duration of drug activity, decreased dosing frequency, improved targeting, as well as reductions in toxic metabolites. (
  • Therefore, hydrogel -based local drug delivery systems have their unique advantages especially in sensitizing postoperative radiotherapy . (
  • This market analysis does not include drug-eluding stents or prefilled or regular syringes. (
  • It was also established that the manufacture of different drug delivery systems such as insulin pumps, API infused contact lenses and drug-coated stents by different medical devices companies are common in Ireland, and some of these devices are being sold globally. (
  • Liposomal drug delivery systems: from concept to clinical applications. (
  • By affecting the absorption, distribution, metabolism and elimination of drug compounds, various drug delivery technologies improve the therapeutic effect at the intended site of action while minimizing possible adverse effects. (
  • The amount of drug delivered via the temporal pressure method was also comparable to the amount delivered by a microneedle patch - dozens of needles smaller than the width of a human hair made from biocompatible compounds, commonly used to deliver small amounts of drugs through the skin over time. (
  • We also assessed messages discussing synthetic cannabinoid-related compounds, a class of drugs distinct from cannabis that also interact with the human endocannabinoid system. (
  • But understanding how the immune system works can help bring clarity to the reasons some people could benefit from the authorized shots. (
  • The immune system quickly recognizes that these foreign proteins do not belong, and it generates an immune response to fight them off. (
  • Alongside, models are developed and tested in order to understand and predict phenomena subsequent to light absorption, covering a wide variety of processes such as molecular reactivity, the responses of the immune system, drug-delivery and gene therapy. (
  • Yet, the driving applications (e.g., efficient lab-on-a-chip applications, artificial immune system, targeted and coordinated drug delivery, and continuous health monitoring) require coordination and communication of nodes at small scales. (
  • Many aspects of the immune system and mechanisms of immune-modulated therapies remain to be elucidated in order to exploit fully the emerging opportunities. (
  • Many nanomaterials have been shown to interact with the immune system by either stimulating or suppressing various responses through their interaction with proteins found within blood. (
  • The mRNA vaccines by Pfizer-BioNTech and Moderna provide the blueprint for the spike protein in the form of mRNA in a drug-delivery system called a lipid nanoparticle . (
  • An analysis evaluating the effectiveness of various vaccines delivery devices in order to compare their respective strengths and capabilities based on a variety of parameters. (
  • The feasibility of the synthesized polymers as drug nanodelivery systems was investigated. (
  • In the present study, the preparation of similar delivery systems is described, in which differing drugs and polymers were used to ascertain the mechanism governing the drug-release kinetics. (
  • We aim at the development of new polymeric materials including cellulose-based polymers functionalization, conducting and luminescent sensing polymers and bio-hydrogels for drug delivery and water remediation. (
  • This is complemented by a background on transport property analysis, involving inter-, intra- and thermal diffusion of multicomponent systems in aqueous solution and through polymers. (
  • New York, September 10, 2009 - Many of the novel biopharmaceutical drugs developed now can only be delivered by injection, and this has biologic manufacturers seeking out the most patient-friendly options, including needle-free systems. (
  • Doxorubicin, as a model anticancer drug, was employed to compare SERS with conventional fluorescence tracing approaches. (
  • Future work is also needed to develop advanced analytic approaches such as machine learning, natural language processing, or topic modeling-based strategies to prospectively detect emerging trends with high fidelity from background noise, including identifying specific adverse drug reactions. (
  • ABSTRACT This review describes systems-level innovations that may enhance accessibility, economy and integration of treatment services for substance-related disorders. (
  • As a drug delivery system they enhance the therapeutic efficacy of the drug and minimize adverse effect and toxic reactions. (
  • however, the process of drug delivery plays an essential role in influencing the safety and efficacy of the drug. (
  • An advanced mode of drug delivery system has been developed to overcome the major drawbacks associated with conventional drug delivery systems. (
  • The valuable role of immunotherapy in oncology is increasingly recognized alongside conventional chemo- and radio-therapies, and the US Food and Drug Administration has approved the use of immunotherapy in melanoma, leukemias, lymphomas and myelomas, and in breast, cervical, ovarian, kidney, prostate and colorectal cancers. (
  • Compared to conventional injection where the skin has to be penetrated and there is a risk of a hypoglycaemia effect - when the injected insulin acts too fast and the patient gets dizzy - the new method is able to slowly deliver drugs over time without breaking the skin, thus causing less pain. (
  • Drug delivery technologies modify drug release profile, absorption , distribution and elimination for the advantage of improving product efficacy and safety, as well as patient convenience and compliance. (
  • The colon therefore represents an ideal absorption site for sensitive drugs such as peptides and proteins. (
  • A recent research led by Sylvain Martel, Ph.D., Director of the Polytechnique Montréal NanoRobotics Laboratory, and funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) has shown that magnetic bacteria may be used as drug delivery vehicles for delivering tumor-fighting drugs. (
  • Novel drug delivery systems : fundamentals, developmental concepts, biomedical assessments / Yie W. Chien, with the assistance of Bernard E. Cabana and Stanley E. Mares. (
  • Lead author of the paper, Dr Daniel Lio , who did this research as part of his doctoral thesis at NTU's School of Chemical and Biomedical Engineering, Interdisciplinary Graduate Programme , said that while needles and microneedle injections damage the skin, micropores could pave the way towards painless transdermal delivery of drugs such as insulin. (
  • Assoc Prof Wang Xiaomeng from the NTU Lee Kong Chian School of Medicine, and Assistant Prof Xu Chenjie from the School of Chemical and Biomedical Engineering, tested the delivery of insulin through the skin of mice using the new method. (
  • The new platform, based on the company's original delivery system (DuraSite), is designed to permit increased tissue penetration for topically delivered ocular drugs, with the aim of improved efficacy and dosing convenience. (
  • We believe [it] could be critical in optimizing the profile of approved and future ocular drugs, extending the drug retention on the eye and reducing dosing frequency and the amount of drug needed to achieve efficacious results. (
  • In India drug development technology is still in nascent stage with academia and research institutes collaboration as main stay of the development of novel products. (
  • The purpose of this research was to develop the pseudo-ternary phase diagrams for a model drug delivery system consisting of vitamin E (model drug) + soybean oil + surfactant + co-surfactant (anhydrous glycerol) + water. (
  • According to BCC Research (, the global market for advanced drug delivery systems was valued at $151.3 billion in 2013. (
  • Research is going on using transgenic plants as a source for expression systems, thus changing the way antibodies are produced and bringing growth in the market. (
  • The aim of this research was to develop a SCDDS for the oral delivery of peptide/protein-based drugs, using inorganic/organic particles as core, gamma globulin (γ-globulin) as a model drug, fatty acid (FA) as a shell material and SCFT as the processing method. (
  • For the present research, three systems were validated, two of them with cross-linked cores and the other without chemical stabilization. (
  • Drug delivery system research includes not only the drug itself, but also the carrier materials and devices for the drug, as well as the technologies related to physicochemical modification and modification of the drug or carrier. (
  • Emphasis is also laid on recent developments in the area of nanodrug delivery such as NTX-loaded micelles and nanogels as well as related research avenues. (
  • Nano-enabled drug delivery systems for brain cancer and Alzheimer's Disease: Research patterns and opportunities. (
  • Research will now focus on developing the system to make it safe and ready for human use. (
  • Previous research has focused on creating a machine that is recognized by the body, similar to the way a security system would recognize an authorized person. (
  • Its mission is to promote excellence in research in the Chemical Sciences, by elucidating and controlling molecular mechanisms, developing new fundamental theories, and meeting the evolving technological needs of our society through the design and synthesis of new molecular systems and devices. (
  • His research has elevated food from more than simply a source of calories to being recognized as an exceptionally powerful drug. (
  • This research is based on using wearable devices in controlled drug delivery and the challenges involved in the design, manufacturing, and sales of the devices. (
  • This research aims at exploring how wearables devices can be incorporated in the control of drug delivery systems. (
  • 1. To define the process involved in the research, development, manufacture, and sale of the wearable device-controlled drug delivery system in Ireland. (
  • His research focused on drug and gene delivery systems. (
  • Scientists from Nanyang Technological University , Singapore (NTU Singapore) and the Agency for Science, Technology and Research (A*STAR) have showed that applying "temporal pressure" to the skin of mice can create a new way to deliver drugs. (
  • Based on region, the global drug delivery technology market can be divided into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. (
  • North America is expected to dominate the global drug delivery technology market during the forecast period. (
  • It improves the bioavailability of drug (Kim et al. (
  • Self-emulsifying drug delivery systems are a vital tool in solving low bioavailability issues of poorly soluble drugs. (
  • This results in low drug bioavailability and poor selectivity for diseased cells over normal ones, increasing the risk of serious adverse reactions and drug resistance. (
  • To date, there are data on the creation of delivery systems based on glycyrrhizic acid (GA) and its derivatives, but such a delivery system has not been used for allergen-specific therapy until now. (
  • Topics addressed include fundamental studies involving photophysical processes in various systems including indigo derivatives, and practical applications. (
  • Chitosan-Based Systems for Biopharmaceuticals provides a concise and up-to-date overview of the application of chitosan and its derivatives in the development and optimization of biopharmaceutical medicinal products. (
  • Cutaneous are under investigation because of the challenges of leishmaniasis is a vector-borne parasitic disease caused antimoniate derivatives, including injection site pain, by different Leishmania species and transmitted through high cost, severe adverse effects, variable efficacy and sand fly bites, specifically in uncovered parts of the drug resistance. (
  • Onpattro is the first siRNA-loaded lipid nanoparticle approved by the U.S. Food and Drug Administration (FDA) and consists of ionizable lipids, cholesterol, PEGylated lipids, and helper lipids. (
  • In contrast to soluble chemicals, cadmium oxide particles on a cm2/ml media basis, but are only ~50 particles can settle, diffuse, and aggregate differentially accord- times more potent when differences in delivery to adherent cells are ing to their size, density, and surface physicochemistry. (
  • How to deliver chemotherapeutic drugs efficiently and selectively to tumor cells to improve therapeutic efficacy remains a difficult problem. (
  • Renishaw's drug delivery system will be used in partnership with pharma company Herantis Pharma's drug CDNF in p phase 1-2 clinical trials. (
  • Increasing number of clinical trials, rising investments by key players in this region, low labor costs, and large patient pools are some key factors that are expected to drive the drug delivery technology market. (
  • A prospective randomized clinical trial of chronic CME found that combination therapy with ketorolac 0.5% and prednisolone acetate 1.0% 4 times a day was more effective than either drug alone in improving visual acuity. (
  • However, nanocarriers rely on the body's circulatory system to carry them to the tumor and a large percentage of them are filtered out of the body before reaching the tumor site. (
  • This new drug delivery system (DDS) shows targeted cytotoxicity towards cancer cells via pH-cleavable covalent carboxylic hydrazone links and the SERS tracing capability based on [email protected] nanocarriers. (
  • Drug products topically administered via the skin fall into two general categories, those applied for local action and those for systemic effects. (
  • In the animal experiments, two magnets were used to apply pressure on the mouse dorsal skin for 1 or 5 minutes, depending on how fast the drug delivery is needed, before being removed and the drug is then topically applied like a cream. (
  • According to the experimental results, the drug is released from gelatin microspheres according to the drug loading and the drug solubility. (
  • Dendrimers have the ability to encapsulate and bind the guest molecule can be used for solubility enhancement, sustained release and various drug delivery applications. (
  • The center has expertise in medicine, advanced nanoparticle development, targeted delivery systems for drugs and biologics, and has developed novel transfection and transport platforms. (
  • The oral drug delivery segment is expected to hold a dominant share of the drug delivery technology market owing to factors such as their noninvasive nature, ease of storage, cost effectiveness, and easy portability. (
  • This laboratory develops processes for drug synthesis, namely photosensitizers and potential antibiotics to inactivate viruses and bacteria by photodynamic therapy. (
  • Chapter 6 investigated a class of well-defined glucose-sensitive microgels as an insulin drug release carrier, obtained via polymerization of 4-vinylphenylboronic acid (VPBA), 2-(dimethylamino) ethyl acrylate (DMAEA), and andoligo(ethylene glycol)methyl ether methacrylate (MEO5MA). (
  • Alameda, CA -InSite Vision has introduced a next-generation delivery system (DuraSite 2) as a platform for emerging ophthalmic drugs. (
  • Technological advancements are aiding in further investigation and development of novel antibody drugs, including antibody drug conjugates and bi-specific antibodies that attack the proteins present inside a cancerous cell. (
  • In the United States, more than a dozen needle-free jet injectors have been licensed by the Food and Drug Administration and are on the market. (
  • Major application includes treatment of infection of the reticuloendothelial system (RES), enzyme replacement therapy in the liver, treatment of cancer, and vaccination. (
  • The use of such advanced drug delivery devices has, so far, been demonstrated to improve disease management at home, enabling healthcare professional to periodically monitor compliance to therapy. (
  • Also, based on findings on cell functions at the tissue level obtained by the analysis of the organ on a chip, cell delivery therapy was investigated. (
  • To improve current cancer therapy, the delivery of drug-loaded NPs has to be enhanced. (
  • Antimicrobial therapy using a local drug delivery system (Arestin) in the treatment of peri-implantitis. (
  • In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of ACE-inhibitors with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. (
  • while thermo-sensitive nonlinear poly(ethylene glycol) (PEG) gel shell can trigger the drug release by local temperature change, offering sustained drug release profiles. (
  • The original delivery system is used in two commercial products for the treatment of bacterial eye infections, azithromycin (AzaSite, Merck) and besifloxacin (Besivance, Bausch + Lomb). (
  • Both imaging and drug release could thus be achieved by a single US modality, enabling in situ treatment guided by real-time imaging. (
  • Medical treatment of chronic postoperative CME typically begins with a course of anti-inflammatory drugs such as topical corticosteroids and/or NSAIDs. (
  • Laboratory testing focussed on epileptic seizures in particular because of the challenges of long-term treatment with current anti-epileptic drugs and the large number of patients with drug-resistant epilepsy. (
  • Objectives: We aimed to evaluate the pharmacological potential of Lavandula stoechas L. extracts for anti-ulcer activity, and compare with the standard drugs and to explore novel treatment for peptic ulcer. (
  • While it is convenient to receive treatment at home without having to travel to a healthcare facility, the notion of administering drug injections, or even the sight of needles, can be intimidating to many individuals. (
  • delivery systems and to continue regular treatment. (
  • After introducing a conceptual model to describe the resources, qualities and effectiveness of drug treatment services, evidence is reviewed in three areas (primary care, criminal justice, and mental health) that illustrate how systems-level concepts can be used to organize services to maximize their population impact. (
  • He holds 13 U.S. Patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease. (
  • This webinar will introduce the current treatment therapies and update on the progress on development and application of advanced biosensors, drug delivery systems and other advances for CNS-TB. (
  • Six times greater quantity of drug diffused through the skin of mice with the micropores compared to the skin of mice which did not receive the temporal pressure treatment. (
  • Sustained-release drug delivery systems for the treatment of glaucoma. (
  • MARLBOROUGH, Mass.--( BUSINESS WIRE )-- Sunovion Pharmaceuticals Inc. (Sunovion) today announced that the U.S. Food and Drug Administration (FDA) has accepted for review the New Drug Application (NDA) for SUN-101 (glycopyrrolate), a nebulized long-acting muscarinic antagonist (LAMA), delivered via PARI's innovative investigational eFlow ® closed system nebulizer, for the long-term, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD). (
  • The innovative, proprietary eFlow ® nebulizer system, developed by PARI Pharma GmbH, is a unique closed system delivery device currently in development for the treatment of moderate-to-very severe COPD. (
  • By combining glycopyrrolate, a proven therapeutic option for COPD, with an advanced, handheld nebulizer delivery system designed to reduce the amount of time required for a treatment, SUN-101/eFlow ® has the potential to be a valuable alternative therapeutic option for patients who suffer from COPD. (
  • While these data support the NDA filing which has been accepted by the U.S. Food and Drug Administration (FDA), acceptance of the NDA does not mean that SUN-101/eFlow ® will be approved by the FDA for the treatment of adults with COPD. (
  • The investigational combined product, consisting of SUN-101 and the eFlow ® closed system nebulizer which has been optimized for SUN-101 delivery, has not been approved by the U.S. Food and Drug Administration (FDA) for the treatment of COPD. (
  • treatment and care-delivery strategies are needed. (
  • New treatment strategies, such as the use of technology and Center for Prevention and innovative means of health-care delivery that rely on health professionals other than physicians, represent promising Wellness, George Washington options, particularly for patients with overweight and patients with mild to moderate obesity. (
  • This leads to in situ solubilization of drug that can subsequently be absorbed by lymphatic pathways, bypassing the hepatic first-pass effect. (
  • New and emerging delivery systems - including rectal, vaginal, lymphatic implanted, or transdermal applications - for traditional pharmaceuticals are more effective and cause fewer side effects if delivered in forms that allow a continuous or extended release of the drug. (
  • The approach could overcome intrinsic mismatch of key metrics (e.g., pharmacokinetics, selectivity, biodistribution) between imaging and therapeutic agents, thereby allowing for precise, imaging-guided drug delivery. (
  • Due to their ability to increase the therapeutic index and to improve the selectivity of drugs (targeted delivery), nanodrug delivery systems are considered as promising sustainable drug carriers for NTX in addressing opiate and alcohol dependence. (
  • The new delivery system "has surpassed our expectations, achieving multifold tissue penetration and positive safety results in a well-designed, large-scale preclinical study," said Lyle Bowman, PhD, vice president of development of InSite Vision. (
  • To comprehensively evaluate any therapeutic delivery vehicle, detailed testing of pharmacodynamics and pharmacokinetics in preclinical models similar to the human condition is critical. (
  • More importantly, the application of high acoustic pressure bursts MBs, which releases therapeutic Lipos and further enhances their intracellular delivery through sonoporation effect. (
  • The use of topical medications does not result in significant drug concentrations in the blood and other tissues, and causes fewer adverse reactions. (