Drug Contamination
Equipment Contamination
Food Contamination
Food Microbiology
Decontamination
Disinfection
Water Microbiology
Drug Packaging
Containers, packaging, and packaging materials for drugs and BIOLOGICAL PRODUCTS. These include those in ampule, capsule, tablet, solution or other forms. Packaging includes immediate-containers, secondary-containers, and cartons. In the United States, such packaging is controlled under the Federal Food, Drug, and Cosmetic Act which also stipulates requirements for tamper-resistance and child-resistance. Similar laws govern use elsewhere. (From Code of Federal Regulations, 21 CFR 1 Section 210, 1993) DRUG LABELING is also available.
Water Supply
Environmental Monitoring
Water Pollutants, Chemical
Soil Pollutants
Air Microbiology
Food Handling
Environmental Pollution
Colony Count, Microbial
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Water Pollutants
Sterilization
Water Pollution, Chemical
Cesium Radioisotopes
Dental Equipment
Hand Disinfection
Metals, Heavy
Contaminations occurring in fungal PCR assays. (1/744)
Successful in vitro amplification of fungal DNA in clinical specimens has been reported recently. In a collaboration among five European centers, the frequency and risk of contamination due to airborne spore inoculation or carryover contamination in fungal PCR were analyzed. The identities of all contaminants were specified by cycle sequencing and GenBank analysis. Twelve of 150 PCR assays that together included over 2,800 samples were found to be contaminated (3.3% of the negative controls were contaminated during the DNA extraction, and 4.7% of the PCR mixtures were contaminated during the amplification process). Contaminants were specified as Aspergillus fumigatus, Saccharomyces cerevisiae, and Acremonium spp. Further analysis showed that commercially available products like zymolyase powder or 10x PCR buffer may contain fungal DNA. In conclusion, the risk of contamination is not higher in fungal PCR assays than in other diagnostic PCR-based assays if general precautions are taken. (+info)Variation of hepatitis C virus following serial transmission: multiple mechanisms of diversification of the hypervariable region and evidence for convergent genome evolution. (2/744)
We have studied the evolution of hepatitis C virus (HCV) from a common source following serial transmission from contaminated batches of anti-D immunoglobulin. Six secondary recipients were each infected with virus from identifiable primary recipients of HCV-contaminated anti-D immunoglobulin. Phylogenetic analysis of virus E1/E2 gene sequences [including the hypervariable region (HVR)] and part of NS5B confirmed their common origin, but failed to reproduce the known epidemiological relationships between pairs of viruses, probably because of the frequent occurrence of convergent substitutions at both synonymous and nonsynonymous sites. There was no evidence that the rate at which the HCV genome evolves is affected by transmission events. Three different mechanisms appear to have been involved in generating variation of the hypervariable region; nucleotide substitution, insertion/deletion of nucleotide triplets at the E1/E2 boundary and insertion of a duplicated segment replacing almost the entire HVR. These observations have important implications for the phylogenetic analysis of HCV sequences from epidemiologically linked isolates. (+info)Postsurgical Candida albicans infections associated with an extrinsically contaminated intravenous anesthetic agent. (3/744)
From 16 to 30 April 1990, four of 364 (1%) postsurgical patients at one hospital developed Candida albicans fungemia or endophthalmitis. The case patients' surgeries were clustered on two days. To identify risk factors for C. albicans infections, we conducted a cohort study comparing these 4 patients with 67 control patients who had surgeries on the same days but did not acquire C. albicans infections. The participation of anesthesiologist 9 (relative risk [RR], undefined; P < 0.001) and receipt of intravenous propofol, an anesthetic agent without preservative, which was administered by an infusion pump (RR, 8.8; P = 0.048) were identified as risk factors for C. albicans infections. The anesthetic had been recently introduced in the hospital. Hand cultures of 8 of 14 (57%) anesthesiologists were positive for Candida species; one yielded C. albicans. Anesthesiologist 9 was the only one to use stored syringes of propofol in the infusion pump and to reuse propofol syringes. DNA fingerprinting with a digoxigenin-labeled C. albicans repetitive element 2 probe and electrophoretic karyotyping showed two distinct banding patterns among patient isolates. We hypothesize that extrinsic contamination of propofol by anesthesiologist 9 likely resulted in C. albicans infections. These data suggest that strict aseptic techniques must be used when preparing and administering propofol. (+info)GB virus C/hepatitis G virus infection in HIV infected patients with haemophilia despite treatment with virus inactivated clotting factor concentrates. (4/744)
AIM: To determine the frequency of GB virus C (GBV-C)/hepatitis G virus (HGV) infection before and after switch to the use of virus inactivated concentrates in haemophiliac patients infected with human immunodeficiency virus (HIV). PATIENTS AND METHODS: Initial and follow up sera from 49 children with haemophilia were analysed for the presence of GBV-C/HGV RNA and antibodies to HGV (anti-HGV). All patients had been infected with HIV while receiving concentrates without virus inactivation before 1984 and were subsequently treated with virus inactivated concentrates. RESULTS: In the first available serum sample (1987 or later), two of 49 patients were GBV-C/HGV RNA positive and two further patients were anti-HGV positive. During follow up (mean, 6 years), 14 patients developed markers of GBV-C/HGV infection. Eleven of these had received no blood products except clotting factor concentrates that had been prepared with virus inactivation. CONCLUSIONS: Despite being treated with virus inactivated clotting factor concentrates, HIV positive patients with haemophilia are at an increased risk of manifesting GBV-C/HGV infection. We hypothesise that GBV-C/HGV is transmitted by these clotting factor concentrates. However, we cannot rule out the emergence of markers of GBV-C/HGV infection as a result of the progression of immune impairment in the course of HIV infection. (+info)Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. Irish Hepatology Research Group. (5/744)
BACKGROUND AND METHODS: In February 1994, batches of anti-D immune globulin used in Ireland during 1977 and 1978 to prevent Rh isoimmunization were found to be contaminated with hepatitis C virus (HCV) from a single infected donor. In March 1994, a national screening program was initiated for all women who had received anti-D immune globulin between 1970 and 1994. Of the 62,667 women who had been screened when this study began, 704 (1.1 percent) had evidence of past or current HCV infection, and 390 of those 704 (55 percent) had positive tests for serum HCV RNA on reverse-transcription-polymerase-chain-reaction analysis. All 390 were offered a referral for clinical assessment and therapy. We evaluated 376 of these 390 women (96 percent); the other 14 were not seen at one of the designated treatment centers. RESULTS: The mean (+/-SD) age of the 376 women was 45+/-6 years at the time of screening. They had been infected with hepatitis C for about 17 years. A total of 304 women (81 percent) reported symptoms, most commonly fatigue (248 [66 percent]). Serum alanine aminotransferase concentrations were slightly elevated (40 to 99 U per liter) in 176 of 371 women (47 percent), and the concentrations were 100 U per liter or higher in 31 (8 percent). Liver biopsies showed inflammation in 356 of 363 women (98 percent); in most cases the inflammation was slight (41 percent) or moderate (52 percent). Although the biopsy samples from 186 of the 363 women (51 percent) showed evidence of fibrosis, only 7 women (2 percent) had probable or definite cirrhosis. Two of the seven reported excessive alcohol consumption. CONCLUSIONS: Most of the women with HCV infection 17 years after receiving HCV-contaminated anti-D immune globulin had evidence of slight or moderate hepatic inflammation on liver biopsy, about half had fibrosis, and 2 percent had probable or definite cirrhosis. (+info)Cluster of postinjection abscesses related to corticosteroid injections and use of benzalkonium chloride. (6/744)
Benzalkonium chloride (BC) is an unreliable disinfectant. A matched case-control study and environmental investigation were conducted to determine the cause of and risk factors for a cluster of postinjection abscesses at a private medical clinic where BC was used as a disinfectant. Twenty-eight case-patients who had an abscess at the injection site were matched with 126 control patients who had received an intramuscular injection at the clinic on the same day. Risk factors for abscess development in a multivariable logistic model were corticosteroid injection and being female. All case-patients had received a corticosteroid injection from a multidose vial. Cultures of abscesses from 20 of 23 case-patients grew Pseudomonas aeruginosa. Cultures of BC prepared at the clinic also grew P aeruginosa, suggesting that BC was the source of infection. Injection site cleaning with BC did not appear to be the route of infection since use of BC at the time of injection was not associated with abscess development. A more likely route of infection was injection of contaminated corticosteroid from multidose vials that could have been inoculated with pseudomonads via needle puncture after vial septa were wiped with contaminated BC. Benzalkonium chloride should not be used to clean injection vial septa or injection sites. (+info)Peripheral blood stem cell contamination in mantle cell non-Hodgkin lymphoma: the case for purging? (7/744)
Intensification using peripheral blood stem cells collected after chemotherapy followed by growth factors is being increasingly investigated as an alternative to conventional chemotherapy for mantle cell non-Hodgkin lymphoma. We investigated 14 grades III-IV, t(11;14)-positive cases for contamination of PBSC collected after a polychemotherapy regimen followed by G-CSF. Patients were first treated with a polychemotherapy regimen. There were four CR, seven PR, two refractory and one early death. Seven patients have been transplanted, in whom PBSC were mobilized, using either cyclophosphamide/VP16 or Dexa-BEAM followed by G-CSF. For all patients, whether actually autografted or not, PB cells were tested at the time of regeneration on G-CSF after the first polychemotherapy or after the mobilizing regimen. PCR evaluation of contamination was performed first by a semi-quantitative approach, using serial dilutions of initial DNA, then confirmed using a limiting-dilution analysis. Two patients were not informative (one early death and one without an available molecular marker). PB cells collected at regeneration contained at least one log more lymphoma cells than steady-state blood or marrow, apart from in two cases. Moreover, where a mobilizing treatment diminished tumor burden in the patient, at the same time it increased PB contamination in most cases. We conclude that advanced mantle cell NHL appears to be largely resistant to significant in vivo purging by conventional chemotherapy. Where treatment brings benefits by reducing tumor load, it may at the same time negate it by mobilizing malignant cells into the collections used to intensify. Although the clonogenic potential of this massive infiltration is unknown (only gene marking studies could provide a definitive answer regarding the source of relapses), strategies aimed at reducing the level of contamination in the graft should be considered when designing future protocols. (+info)Inhibition of P-glycoprotein-mediated transport by a hydrophobic contaminant in commercial gluconate salts. (8/744)
The substitution of gluconate for Cl- is commonly used to characterize Cl- transport or Cl--dependent transport mechanisms. We evaluated the effects of substituting gluconate for Cl- on the transport of the P-glycoprotein substrate rhodamine 123 (R123). The replacement of Ringer solution containing Cl- (Cl--Ringer) with gluconate-Ringer inhibited R123 efflux, whereas the replacement of Cl- by other anions (sulfate or cyclamate) had no effect. The inhibition of R123 efflux by gluconate-Ringer was absent after chloroform extraction of the sodium gluconate salt. The readdition of the sodium gluconate-chloroform extract to the extracted gluconate-Ringer or to cyclamate-Ringer inhibited R123 efflux, whereas its addition to Cl--Ringer had no effect. These observations indicate that the inhibition of P-glycoprotein-mediated R123 transport by gluconate is due to one or more chloroform-soluble contaminants and that the inhibition is absent in the presence of Cl-. The results are consistent with the fact that P-glycoprotein substrates are hydrophobic. Care should be taken when replacing ions to evaluate membrane transport mechanisms because highly pure commercial preparations may still contain potent contaminants that affect transport. (+info)
List of food contamination incidents
2004 - Organic free-range chicken was found to contain traces of the banned veterinary drug, nitrofuran. Up to 23 tonnes of ... 2013 aflatoxin contamination - Contamination with aflatoxins results in a milk recall in Europe and a dog food recall in the ... 2018 Australian strawberry contamination, where strawberries were found to contain needles. 2019 - Dioxin contamination of eggs ... 1989 - Milk contamination with dioxin in Belgium 1993 - Jack in the Box E. coli outbreak - Escherichia coli O157:H7 bacterium ...
List of medicine contamination incidents
... so this kind of contamination may be more widespread and undetected in generic drugs. List of food contamination incidents List ... Generic drug manufacturers often change the way in which prescription drug ingredients are made in order to lower costs of ... Food and Drug Administration, Poisons, Lists of disasters in the United States, Drug safety, Medical scandals, Lists of ... from 2012 until the drugs were recalled from the world drug market in 2018. The problem began in 2012, when the process for ...
Contamination
Ogbede, J.U., Giaever, G. & Nislow, C. A genome-wide portrait of pervasive drug contaminants. Sci Rep 11, 12487 (2021). https ... This sort of contamination can result in the decertification of a farm. This sort of contamination can at times be difficult to ... Paull, J. (2014). "Editorial: Organic Versus GMO Farming: Contamination, What Contamination?". Journal of Organic Systems. 9 (1 ... Contamination may be recognized or not and may become an issue if the impure chemical causes additional chemical reactions when ...
Michael Riconosciuto
No drug-lab contamination was found at the laboratory site and a member of the DOE's Hazardous Spill Response Team asserted ... "No Drug-lab Contamination Found". The Wenachee World. 1991-05-14. "Analysis of Noble Metals". Academic Press. 1977. Bua report ... "Defendant Says Government Drug Charges Are Part Of Vendetta". Seattle Times Company. Associated Press. 1992-01-02. Retrieved ... During his trial, Riconosciuto accused the Drug Enforcement Administration of stealing two copies of his tape. Riconosciuto ...
Pavle Jovanovic (bobsledder)
Such contamination has been a common problem. Bad labeling, lying, intentional or accidental cross-contamination, and poor ... In an interview, he pulled items out of a bag and showcased them, referring them as "illegal drugs" and as would "a lawyer ... Jovanovic returned to bobsleigh in 2003 and was drug-free as of 2006[update]. The suspension of Jovanovic for the use of ... However, he failed a drug test on December 29, 2001, for ingesting Nitro Tech, a nutritional supplement he purchased at a ...
Ameridose
"FDA Finds Contamination Issues at Ameridose." USA Today. Gannett, 13 Nov. 2012. Establishment Inspection Report, Food and Drug ... and green were observed in several hoods where drugs are made Drugs were shipped out before sterility tests were complete ... Due to pressure from the state and the U.S. Food and Drug Administration (FDA) because of growing concern of their association ... "Ex-Workers Cite Safety Concerns At a Drug Firm." The New York Times. The New York Times, 13 Oct. 2012. Web. 04 Jan. 2013. ...
Antidepressant
Part II: the antidepressant drug fluoxetine". Archives of Environmental Contamination and Toxicology. 52 (2): 163-170. doi: ... "Top 200 generic drugs by units in 2010" (PDF). Archived from the original (PDF) on 15 December 2012."Top 200 brand drugs by ... Media related to Antidepressants at Wikimedia Commons Antidepressants Drug classes defined by psychological effects Drugs by ... Clomipramine, a TCA drug, is considered effective and useful for OCD, however it is used as a second line treatment because it ...
Metalaxyl
Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 1058 Sukul, P; Spiteller, M (2000 ... "Metalaxyl: persistence, degradation, metabolism, and analytical methods". Reviews of Environmental Contamination and Toxicology ...
Clevidipine
Do not use if contamination is suspected. Once the stopper is punctured, use or discard within 12 hours. No clinical drug ... American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions. 9 (2): 117-34. doi:10.1007/BF03256583. PMID ... Titrate drug depending on the response of the individual patient to achieve the desired blood pressure reduction. Monitor blood ... Clevidipine is used IV only and practitioners titrate this drug to lower blood pressure. It has a half-life of approximately ...
Clenbuterol
Duchaine popularized the drug in the bodybuilding community, and was the first to suggest the drug had muscle-building ... Not just athletes are affected by contamination. In Portugal, 50 people were reported as affected by clenbuterol in liver and ... FDA's Prohibited Drug List, Food Animal Residue Avoidance & Depletion Program "Animal Drugs @ FDA". www.accessdata.fda.gov. ... Clenbuterol is not an ingredient of any therapeutic drug approved by the US Food and Drug Administration[citation needed] and ...
Composition of electronic cigarette aerosol
Contamination with various chemicals have been identified. Some products contained trace amounts of the drugs tadalafil and ...
Ataxia
Other examples include various prescription drugs (e.g. most antiepileptic drugs have cerebellar ataxia as a possible adverse ... Reviews of Environmental Contamination and Toxicology. Vol. 198. pp. 111-32. doi:10.1007/978-0-387-09647-6_3. ISBN 978-0-387- ... Some drug treatments that have been used to control ataxia include: 5-hydroxytryptophan (5-HTP), idebenone, amantadine, ... A review of a new anticonvulsant drug". Archives of Neurology. 33 (5): 326-332. doi:10.1001/archneur.1976.00500050012003. PMID ...
Polonium
Internal Radioactive Contamination - Development of Decorporation Agents" (PDF). US Food and Drug Administration. Retrieved 7 ... Baselt, R. Disposition of Toxic Drugs and Chemicals in Man Archived 2013-06-16 at the Wayback Machine, 10th edition, Biomedical ... and strict handling procedures to avoid any contamination. Alpha particles emitted by polonium will damage organic tissue ...
Polychlorinated biphenyl
The PCB contamination has spread to the soil, and to the river, where locals will sometimes fish unaware of the danger. In 1976 ... "Nearly a Decade After Spill, Cleanup of Toxic Site Drags On With PM-Rusted Legacy II". AP NEWS. Retrieved 2020-02-19. " ... "Contamination of rice bran oil with PCB used as the heating medium by leakage through penetration holes at the heating coil ... The contamination was so severe that cleanup efforts kept the building closed for 13 years. One of the largest deliberate PCB ...
New England Compounding Center meningitis outbreak
Fungal contamination in relation to sterile drug recalls represents the second-most common form of microbiological ... Drug, and Cosmetic Act to grant the FDA more authority to regulate and monitor the manufacturing of compounding drugs. The Drug ... When FDA scientists tested samples of the drug collected in New York, though, they found bacterial contamination in four of 14 ... and drugs to treat glaucoma, asthma, and erectile dysfunction, and 10 of the 29 drugs failed one or more quality tests. However ...
2007 Chinese export recalls
China's current food and drug safety situation is not very satisfactory because supervision of food and drug safety started ... The prime suspect was contamination indicated by the presence of melamine, an industrial chemical found in plastics and resins ... Its foundation is weak so the supervision of food and drug safety is not easy," said Yan Jiangying, deputy policy director of ... "The nest of corruption in the food and drug administration has done incalculable harm to the state and people," China Daily ...
Contaminated currency
The contamination of paper money is not limited to simply that of cocaine and other illicit drugs. Health officials in the UK ... Additionally, paper money in other parts of the world show a similar drug contamination, and studies indicate that they might ... The drug content is generally too low for prosecution but high enough to trigger response to drug-sniffing dogs. This has been ... Jenkins AJ (1 October 2001). "Drug contamination of US paper currency". Forensic Science International. 121 (3): 189-93. doi: ...
Medical glove
In March 2016, the United States Food and Drug Administration (FDA) issued a proposal to ban their medical use and on December ... Medical gloves are recommended to be worn for two main reasons: To reduce the risk of contamination of health-care workers ... "User Labeling for Devices that Contain Natural Rubber (21 CFR 801.437); Small Entity Compliance Guide". Food and Drug ... Medical Glove Powder Report (Report). U.S. Food and Drug Administration. September 1997. Retrieved June 2, 2016. Lan, Jian. " ...
Drug recall
List of withdrawn drugs Contamination control "Safety Recall Definitions". US Food and Drug Administration. Retrieved 20 ... Drug recalls in the United States are made by the FDA or the creators of the drug when certain criteria are met. When a drug ... the drug is removed from the market and potential legal action can be taken depending on the severity of the drug recall. Drug ... "Number of Drug Recalls Surges at FDA, Led by Mid-Level Concerns". "Number of Drug Recalls Surges at FDA, Led by Mid-Level ...
Shane Kenny
Raidió Teilifís Éireann (1991). Annual Report 1989 (PDF). p. 7. "Former RTE presenter, Shane Kenny: 'These drugs, the family of ... O'Sullivan, Kevin (14 August 2020). "Shane Kenny convinced Achill water contamination triggered medical relapse". The Irish ...
2008 Chinese heparin adulteration
The U.S. Food and Drug Administration was quoted as stating that at least 81 deaths were believed to be linked to a raw heparin ... List of medicine contamination incidents "Heparin's Deadly Side Effects". Time magazine. 2008. Archived from the original on 21 ... "Blood-thinning drug under suspicion". Archived from the original on 2012-10-23. FDA informational page with information and ... This caught the attention of the media and the USA Food and Drug Administration leading to numerous ongoing lawsuits. The raw ...
Breast milk
The amount of drug bound by maternal plasma proteins, the size of the drug molecule, the pH of the drug, and the lipophilicity ... Keim SA, Hogan JS, McNamara KA, Gudimetla V, Dillon CE, Kwiek JJ, Geraghty SR (November 2013). "Microbial contamination of ... retrieved 2019-08-05 Drugs, Committee on (2001-09-01). "The Transfer of Drugs and Other Chemicals Into Human Milk". Pediatrics ... Drug Interactions with Human Milk Human milk and lactation by Carol L. Wagner (Overview article, eMedicine, December 14, 2010) ...
Red Hill water crisis
Two of the three wells supplying the Navy water system were shut down due to contamination, but the third well was able to ... Blair, Allyson (September 12, 2022). "As Red Hill crisis drags on, Board of Water Supply races to drill new wells". Hawaii News ... Two other BWS wells were also shut down on December 8 after contamination was found in a second Navy water well. Shutting down ... Camp Lejeune water contamination Flint water crisis Jedra, Christina (January 11, 2022). "Navy Agrees To Comply With Hawaii's ...
2007 pet food recalls
The contamination was caused by melamine in the affected foods. The Chinese company behind the contaminated wheat gluten has ... Wikinews has related news: US Food and Drug Administration reports melamine found in contaminated pet food FDA Food Recall Page ... Possibility of cross-contamination to "safe" pet foods". Pet Super Store Dog Food Recall Page (Articles with short description ... Beginning in March 2007, there was a widespread recall of many brands of cat and dog foods due to contamination with melamine ...
Salmonellosis
Internal contamination can be the result of penetration through the eggshell or by direct contamination of egg contents before ... A similar approach was considered in the United States, but the Food and Drug Administration decided not to mandate vaccination ... to determine the percentage of yolk contamination (a measure used to determine egg contamination resistance, with numbers lower ... South Africa reported contamination of its poultry carcasses by Salmonella. Egypt showed that Salmonella was predominant in ...
Glycerol
"FDA Advises Manufacturers to Test Glycerin for Possible Contamination". U.S. Food and Drug Administration. 4 May 2007. Archived ... On 4 May 2007, the US Food and Drug Administration advised all US makers of medicines to test all batches of glycerol for the ... "Glycerin Enema". Drugs.com. Archived from the original on 6 November 2012. Retrieved 17 November 2012. "glycerin enema". NCI ... In 1937, more than one hundred people died in the United States after ingesting DEG-contaminated elixir sulfanilamide, a drug ...
Unused drug
The improper disposal of unused drugs could be the reason for the contamination of Surface, Ground and Drinking Water. ... Also, drug recycling might be a possibility. Collection of unused drugs, also called drug return or drug take-back, is any ... Storing unused drugs at home can be a safety hazard. Drug disposal is often the right choice for consumers. Some regions offer ... An unused drug or leftover drug is the medicine which remains after the consumer has quit using it. Individual patients may ...
Phytotoxicity
Heavy metal contamination occurs from both natural and anthropogenic sources. The most notable natural source of heavy metals ... Nanotechnology is a rapidly growing industry with many applications, including drug delivery, biomedicines, and electronics. As ...
Dietary exposure assessments in the United States
Global Monitoring System - Food Contamination Monitoring and Assessment Program. [1] "Total Diet Study". Food and Drug ... The World Health Organization implements the Global Environment Monitoring System - Food Contamination Monitoring and ...
Timeline of the 2007 pet food recalls
Melamine contamination is confirmed after a sample was sent to a laboratory at University of California at Davis. United States ... Zheng Xiaoyu, the head of the Chinese State Food and Drug Administration from its founding in 1998 until 2005 receives the ... They found no acetaminophen contamination in three cans of the same food that tested positive for acetaminophen at a Texas ... "Joint Update: FDA/USDA Trace Adulterated Animal Feed to Poultry". USDA and U.S. Food and Drug Administration. April 30, 2007. ...
Norovirus
A 2006 study found the virus remained on surfaces used for food preparation seven days after contamination. Routine protocols ... Ali ES, Rajapaksha H, Jillian MC, Petrovsky N (2016). "Norovirus drug candidates that inhibit viral capsid attachment to human ... Transmission routes are fecal-oral and contamination. When a person becomes infected with norovirus, the virus replicates ... by reverse transcription polymerase chain reaction are being employed by governmental laboratories such as the Food and Drug ...
100,000,000 Guinea Pigs
Many people were shocked at the extent of food contamination and drug side-effects, and 100,000,000 Guinea Pigs, along with ... The book goes on to state that the Pure Food and Drug Act of 1906 is not effective in arresting these trends, and real reform ... "The Story Of The Laws Behind The Labels Part II: 1938--The Federal Food, Drug, and Cosmetic Act". Centre for Food Safety and ... 100,000,000 Guinea Pigs: Dangers in Everyday Foods, Drugs, and Cosmetics is a book written by Arthur Kallet and F.J. Schlink ...
Illicium anisatum
This contamination hospitalized many people with epilepsy, hallucinations, and nausea all as a result of the toxin anisatin, ... FDA Issues Advisory on "Teas": Teas Made from Star Anise Were Associated With Illnesses Including Seizures, US Food and Drug ... In 2001, there was a large outbreak of toxicity in the Netherlands due to accidental contamination of a tea blend containing ...
Scuba set
... which means that the cylinder and cylinder valve have had any non-oxygen-compatible components replaced and any contamination ... An excess of tubes and connections passing through the water tend to decrease swimming performance by causing hydrodynamic drag ...
2022 monkeypox outbreak
Antiviral drugs, cidofovir and tecovirimat, vaccinia immune globulin and the smallpox vaccine may be used during outbreaks. The ... News article: "The contamination of surfaces in hospital rooms housing monkeypox patients". News-Medical.net. 6 July 2022. ... Better understanding of the new monkeypox variant is important for accelerating the development of vaccines and drugs. The UK ... Contaminated surfaces within hospitals and households may be infectious, with widespread contamination of surface and air ...
Yellow fever vaccine
Since 1971, screening technology for HBV has been available and is routinely used in situations where HBV contamination is ... "YF-Vax". U.S. Food and Drug Administration (FDA). 6 August 2019. Retrieved 28 December 2019. World Health Organization (July ... Yellow Fever Vaccine at the US National Library of Medicine Medical Subject Headings (MeSH) "Yellow Fever Vaccine". Drug ... Drugs that are a vaccine, All articles with unsourced statements, Articles with unsourced statements from December 2019, ...
Flexible tanks
For transport in the US, the materials used in the production of flexi-bags must meet the US Food and Drug Administration, EU ... Advantages over rigid storage systems include low cost, less algae growth, lower groundwater contamination, and less ...
Aspiration pneumonia
Sputum cultures are not used for diagnosing aspiration pneumonia because of the high risk of contamination. Clinical symptoms ... Others: Age, male gender, diabetes mellitus, malnutrition, use of antipsychotic drugs, proton pump inhibitors, and angiotensin- ...
2022 in the United States
August 4 Phoenix Mercury star Brittney Griner is found guilty on drug charges in a Russian court and is subsequently sentenced ... Thousands of Capri Sun pouches are also recalled by The Kraft Heinz Company over the possible contamination with a cleaning ... "U.S. basketball star Griner goes on trial in Russia on drug charges". Reuters. July 1, 2022. Murphy, Tim (July 2, 2022). " ... Federal judge Reed O'Connor issues a ruling that the Affordable Care Act's requirement to cover HIV-prevention drugs are ...
Rope
Previous falls arrested by a rope, damage to its sheath, and contamination by dirt or solvents all weaken a rope and can render ... Ropes have tensile strength and so can be used for dragging and lifting. Rope is thicker and stronger than similarly ... allowing each to stay straighter and reduce both individual and total rope drag. Twin ropes are thin ropes which must be ...
Cultured neuronal network
It has been used not only in the study of neuronal plasticity and information processing but also in drug and toxin effects on ... Additionally, when coupled with a sealed incubation chamber this device greatly reduces the risk of culture contamination by ...
Herbal medicine
"Herb-Drug Interactions". NCCIH. 10 September 2015. Retrieved 26 June 2019. Kuhn MA (April 2002). "Herbal remedies: drug-herb ... Newmaster SG, Grguric M, Shanmughanandhan D, Ramalingam S, Ragupathy S (October 2013). "DNA barcoding detects contamination and ... Some prescription drugs have a basis as herbal remedies, including artemisinin, digitalis, quinine and taxanes. In 2015, the ... Certain herbs as well as common fruit interfere with cytochrome P450, an enzyme critical to much drug metabolism. In a 2018 ...
Surface metrology
Contact methods involve dragging a measurement stylus across the surface; these instruments are called profilometers. Non- ... which may alter the surface and/or stylus and cause contamination. Furthermore, due to the mechanical interaction, the scan ...
Ramapough Mountain Indians
The paint sludge has been linked to contamination of food and water sources with lead and benzene. The contamination has been ... They claimed that Out of the Furnace portrays a gang of criminals living in the Ramapo Mountains who are "lawless, drug- ...
Lyme disease
It was granted fast track designation by the U.S. Food and Drug Administration in July 2017. In April 2020 Pfizer paid $130 ... by detection of debris of dead Borrelia cells or specimen contamination. Even when properly performed, PCR often shows false- ... On 21 December 1998, the Food and Drug Administration (FDA) approved LYMErix on the basis of these trials for persons of ages ... Pain associated with Lyme disease may be treated with nonsteroidal anti-inflammatory drugs (NSAIDs). Corticosteroid joint ...
Antimicrobial
Antibacterials are among the most commonly used drugs and among the drugs commonly misused by physicians, for example, in viral ... or other chemical substances from contamination, fouling, or deterioration caused by bacteria, viruses, fungi, protozoa, algae ... Many antiviral drugs are designed to treat infections by retroviruses, including HIV. Important antiretroviral drugs include ... Some of these side effects can be life-threatening if the drug is not used properly.[citation needed] As well as their use in ...
July 1969
Training Drug Use in America: Problem in Perspective (National Commission on Marihuana and Drug Abuse, 1973) p175 "U.S. ... for 17 days as a precaution against having brought any contamination from the Moon back to Earth. U.S. President Nixon, who was ... "War on Drugs" began as U.S. President Nixon sent a message to Congress calling for "a comprehensive legislative proposal" to ... drunk and drugged'", "From the Guardian archive", 8 July 2011, TheGuardian.com "Woman Slain, Friend Is Shot", San Francisco ...
Digital autopsy
... drug-related, or otherwise suspicious deaths. Digital Autopsy tries to answer the same investigative questions without actual ... It is impossible to preserve the body after dissection and gather the findings with non-destructive and contamination-free ...
Rolling-element bearing
Contamination in the lubricant is abrasive and greatly reduces the operating life of the bearing assembly. Another major cause ... Overall, these cause bearing drag. Roller bearings are the earliest known type of rolling-element-bearing, dating back to at ... With all this, GBLM includes the effects of lubrication, contamination, and raceway surface properties, which together ... such as contamination or a failure of lubrication. A new model of bearing life was put forward by FAG and developed by SKF as ...
Sistine Chapel
To the right are those who are assigned to Hell and are dragged down by demons. The Last Judgement was an object of a bitter ... and all of the overpainted areas were contamination of one sort or another: smoke deposits, earlier restoration attempts, and ...
Lockheed SR-71 Blackbird
The angle of incidence of the delta wings could be reduced for greater stability and less drag at high speeds, and more weight ... Metallurgical contamination was another problem; at one point, 80% of the delivered titanium for manufacture was rejected on ... The Blackbird landed at over 170 knots (200 mph; 310 km/h) and deployed a drag parachute to stop; the chute also acted to ... The rotating machinery had become a drag item and the engine thrust at high speeds came from the afterburner temperature rise. ...
Biomedical Tissue Services
... are processed in a way that prevents communicable disease contamination and cross-contamination." To conceal their practices, ... Food and Drug Administration Order to Cease Manufacturing and to Retain HCT/Ps (Webarchive template wayback links, IMDb ID not ... Food and Drug Administration (FDA) on October 8, 2005, after its president, Dr. Michael Mastromarino, and two other employees ...
Hemolysis
Difficult collections, unsecure line connections, contamination, and incorrect needle size, as well as improper tube mixing and ... drug-induced hemolytic anemia, atypical hemolytic uremic syndrome (aHUS)), some genetic disorders (e.g., Sickle-cell disease or ... and drug development". Frontiers in Physiology. Frontiers Media SA. 5: 415. doi:10.3389/fphys.2014.00415. ISSN 1664-042X. PMC ...
Petri dish
They are usually covered, or placed upside-down, to lessen the risk of contamination from airborne spores. Virus or phage ... and medicinal drugs). The agar and other ingredients are dissolved in warm water and poured into the dish and left to cool down ... Petri dishes can be used to visualize the location of contamination on surfaces, such as kitchen counters and utensils, ... 2019): "Product PD1504700 MilliporeSigma PetriSlide for contamination analysis". Fischer Scientific online catalog. Accessed on ...
Heparinoid
Current USP standards for heparin limit levels of contamination with dermatan, chondroitin, and over-sulfated chondroitin ... Carbohydrates in Drug Design. pp. 277-308. ISBN 0-8247-9982-8. {{U.S. Pharmacopeia Heparin Stage Two Monograph Revisions Open ... Clinical Drug Investigation. 28 (10): 603-614. doi:10.2165/00044011-200828100-00001. PMID 18783299. S2CID 31783368. Mehta PP, ...
Cattle feeding
Regulations on veterinary drug use in food animals and drug-residue testing programs ensure that the product in the grocery ... there is still the possibility of cross-contamination of feed going to cattle. Since only a tiny amount of the contaminating ... all veterinary drugs used in food production processes are required to pass tests and regulations set by the Veterinary Drugs ... Cattle feed may also include various substances such as glycerol, veterinary drugs, growth hormones, feed additives or ...
Sonogashira coupling
Drug Dev. Res. 45 (1): 10-16. doi:10.1002/(SICI)1098-2299(199809)45:1. 3.0.CO;2-G. Parkinson Study, Group (14 February 2006). " ... above as less expensive alternatives to palladium catalysts have shown a poor track record of success due to contamination of ...
Fodder
The US Department of Health and Human Services regulates drugs of the Veterinary Feed Directive type that can be present within ... spread through the inclusion of ruminant meat and bone meal in cattle feed due to prion contamination. This practice is now ...
Biofouling
... leading to increased drag of up to 60%. The drag increase has been seen to decrease speeds by up to 10%, which can require up ... Medical devices used in operating rooms, ICUs, isolation rooms, biological analysis labs, and other high-contamination-risk ... The additional drag can decrease speeds up to 10%, which can require up to a 40% increase in fuel to compensate. With fuel ... since fouling on a ship's hull significantly increases drag, reducing the overall hydrodynamic performance of the vessel, and ...
Māngere Inlet
However, the inlet also acts as a natural sedimentation sink, thus being especially at risk of contamination. It is surrounded ... and drag them overland to the other coast, thus avoiding having to paddle around Cape Reinga. This made the area of immense ... However, industrial sewage mixed with stormwater overflows, and other contamination still leads to above-average traces of ...
Protecting Healthcare Workers by Detecting Contamination from Hazardous Antineoplastic Drugs
Antineoplastic drugs, also known as anti-cancer drugs or chemotherapy, are used in the treatment of many types of cancer. ... Protecting Healthcare Workers by Detecting Contamination from Hazardous Antineoplastic Drugs. ... Exposure of healthcare workers to antineoplastic drugs from contaminated surfaces and drug vials in hospitals and pharmacies is ... CDC initially developed the lateral flow immunoassay that allows sampling of surfaces to assess drug contamination. CDC NIOSHs ...
Browsing EB124 by Subject "Drug Contamination"
First-in-human trial of oral drug to remove radioactive contamination begins | National Institutes of Health (NIH)
The Food and Drug Administration has approved two products for removing internal radioactive contamination. These drugs, both ... First-in-human trial of oral drug to remove radioactive contamination begins. NIH-funded clinical trial will determine safety, ... tolerability of experimental drug.. What. A first-in-human clinical trial of an experimental oral drug for removing radioactive ... In contrast, HOPO 14-1 has been formulated as an oral capsule, which would be easier than an intravenous drug to stockpile and ...
First-in-Human Trial of Oral Drug to Remove Radioactive Contamination Begins | NIH: National Institute of Allergy and...
The trial is testing the safety, tolerability and processing in the body of escalating doses of the investigational drug ... A first-in-human clinical trial of an experimental oral drug for removing radioactive contaminants from inside the body has ... The Food and Drug Administration has approved two products for removing internal radioactive contamination. These drugs, both ... First-in-Human Trial of Oral Drug to Remove Radioactive Contamination Begins. NIH-Funded Clinical Trial Will Determine Safety, ...
Quantifying How Cocaine Users Respond to Fentanyl Contamination in Cocaine (NIH HEAL Initiative) | National Institute on Drug...
Quantifying How Cocaine Users Respond to Fentanyl Contamination in Cocaine (NIH HEAL Initiative) ... Quantifying How Cocaine Users Respond to Fentanyl Contamination in Cocaine (NIH HEAL Initiative) ... will quantify for the first time how cocaine users respond to fentanyl contamination in cocaine. This study aims to 1) ...
Liquid Multis, Vitamin D & More Recalled Due to Potential Bacterial Contamination - August 9, 2016 - ConsumerLab.com
Generic Drug Problem Report. If you believe that a generic drug has not acted like the original drug, we would like to know ... Liquid Multis, Vitamin D & More Recalled Due to Potential Bacterial Contamination. On August 8, 2016, PharmaTech, LLC issued a ... Liquid Multis, Vitamin D & More Recalled Due to Potential Bacterial Contamination www.consumerlab.com/recalls/12982/liquid- ... If you have experienced an unexpected and adverse reaction to a dietary supplement, nutritional product, or generic drug, we ...
Subjects: Drug Contamination - Digital Collections - National Library of Medicine Search Results
Drug Contamination. Food Contamination 5. Drugs vs. public health Author(s): Runnels, Moses T. (Moses Thurston), 1849- author ... Food Contamination. Drug Contamination 2. Examinations of drugs, medicines, chemicals, &c., as to their purity and ... Start Over You searched for: Subjects Drug Contamination ✖Remove constraint Subjects: Drug Contamination ... Silver Spring, MD : Center for Drug Evaluation and Research, September 2017 Subject(s): Drug Approval. Drug Contamination. ...
Monterey County reveals contamination in illicit marijuana samples
Carnival Cruise Line embarking drug dogs to stop onboard weed use * Marijuana , ... Monterey County reveals contamination in… Share this:. *Click to share on Facebook (Opens in new window) ... of products failed official laboratory testing due to contamination. A total of 58% failed in total or part due to signs of ... to announce the results of a yearlong effort to test illicit cannabis samples pulled from across the county for contamination ...
Contamination 3d pathway - Safe Handling of Hazardous Drugs
Hazardous drugs must be stored separately from non-hazardous drugs in a manner that prevents contamination and personnel ... Drug administration. A nurse is administering a carcinogenic drug to a patient. The drug is in close proximity to the nurse ... Drug delivery to the wards. Hazardous drugs are transported to wards by a health care worker. Hazardous drug containers can ... Hazardous drugs include carcinogens, mutagens, reprotoxic substances, antiviral drugs, hormones, some bioengineered drugs, and ...
Wisconsin considers banning new drug plant
Dakota County closes Schulze Lake after possible contamination, outbreak. Dakota County closes Schulze Lake after possible ... ND police break down drug laws as MN readies for legal marijuana. ND police break down drug laws as MN readies for legal ... Wisconsin drivers can now legally use the drug and drive. Sue Nowak is a drug prevention specialist with North Central Health ... Marijuana and non-medical use of prescription drugs remain the most popular forms of drug abuse, she said. ...
CBRNE - Chemical Decontamination: Overview, Purpose of Chemical Decontamination, Recognizing a Chemical Contamination
For example, local supplies of drugs, such as atropine, amyl nitrite, and thiosulfate, will be exhausted rapidly in a mass ... Recognizing a Chemical Contamination. Before chemical decontamination can occur, chemical contamination must be recognized. The ... Mismanagement may result in illness in healthcare providers and contamination of the ED; severe ED contamination may ... Greater contamination or exposure more likely results in victims who require early intubation and ventilation. Conversely, ...
Early Release - Posttransfusion Sepsis Attributable to Bacterial Contamination in Platelet Collection Set Manufacturing...
US Food and Drug Administration. Bacterial risk control strategies for blood collection establishments and transfusion services ... Identifying the source of platelet contamination was challenging. We initially hypothesized the contamination was an isolated ... Jones SA, Jones JM, Leung V, Nakashima AK, Oakeson KF, Smith AR, et al. Sepsis attributed to bacterial contamination of ... Bacterial contamination of blood components. Clin Microbiol Rev. 2005;18:195-204. DOIPubMedGoogle Scholar ...
Results of search for 'su:{Drug contamination.}'
›
WHO HQ Library catalog
Drug Injury
Contamination. Many drugs are supposed to be manufactured in sterile environments. If foreign substances come into contact with ... Some drugs are marketed to treat conditions that havent been approved the U.S. Food and Drug Administration. When drugs are ... Drug Manufacturer Responsibilities. Its the drug manufacturers responsibility to ensure their medications are safe to use and ... At Rainwater, Holt & Sexton, our Arkansas drug injury lawyers fight to protect patients like you from negligent drug ...
Pesticide Production Leaves a Legacy of Poisoning and Contamination - eNews Park Forest
Member of Violent Chicago Street Gang Convicted in Federal Racketeering and Drug Trafficking Probe. 4976 views ... Pesticide Production Leaves a Legacy of Poisoning and Contamination. by Gary Kopycinski on June 30, 2014. ... Situations like the poisoning and contamination of Montague, MI by a chemical company producing chemicals used in pesticides or ... has resulted in contamination and hardship. Beyond Pesticides has long advocated for the elimination of hazardous synthetic ...
Direct Reading Detection Kits for Surface Contamination by Anti-Neoplastic (Anti-Cancer) Drugs | Technology Transfer
These detectors are incorporated into kits that allow workers to sample surfaces to assess drug contamination in near real-time ... Anti-neoplastic drugs, also known as anti-cancer drugs or chemotherapy, are used in the treatment of many types of cancer. ... Environmental sampling / detection kit for surface contamination by anti-neoplastic (anti-cancer) drugs in hospitals and ... Direct Reading Detection Kits for Surface Contamination by Anti-Neoplastic (Anti-Cancer) Drugs ...
overdose deaths
Drug Overdose Deaths Increase by More Than 20% in Maine The number of drug overdose deaths in Maine increased by nearly a ... Hartford School Closed Again Tuesday After Fentanyl Contamination, Student Overdose The Sport and Medical Sciences Academy in ... In US First, NYC Opening Supervised Drug Injection Sites Mayor Bill de Blasio announced Tuesday that overdose prevention center ... Chris Sununu and other state officials issued a warning Friday after a recent increase in fatal drug overdoses in the state. ...
FDA Asks Five Companies to Recall Metformin | Ashcraft & Gerel
The FDA requested that five pharmaceutical firms recall the diabetes drug Metformin due to high levels of NDMA. Learn more at ... NDMA Contamination Discovered in Diabetes Drug. In December 2019, the U.S. Food and Drug Administration (FDA) began an ... This is not the first time the FDA has been forced to issue a formal warning about NDMA contamination in common medications. In ... Valisure alerted FDA last year of similar NDMA contamination and cancer risks associated with Zantac. ...
Nitrosamines as Impurities in Drugs; Health Risk Assessment and Mitigation Public Workshop - 03/29/2021 - 03/30/2021 | FDA
... including presentations on introductory concepts followed by an overview of the nitrosamine contamination in pharmaceuticals. ... Nitrosamines as Impurities in Drugs; Health Risk Assessment and Mitigation Workshop, ... The Food and Drug Administration (FDA) is announcing a virtual public workshop entitled: ... Discuss the recent drug contamination with nitrosamines.. DESCRIPTION. This public workshop is scheduled and planned as a ...
Images From the History of the Public Health Service: Index of Images
drugs:. adulteration, 108. atomic contamination, 114. cosmetics and drugs, 112. drug abuse, 121, 128 to 134. drug inspectors, ... food and drugs, 105. food safety, 104. pure food and drugs, 103. vaccines and serums, 53 rehabilitation:. drug addicts, 132. ... over-the-counter drugs, 120. patent medicine, 106, 107. pure food and drugs, 103. research, 101. safety of drugs, 105 to 107. ... drugs, 105, 112. interstate commerce, 108. of food, 104. medical devices, 115. over, to, the-counter drugs, 111, 112, 120. ...
PetArmor Fastact Plus Flea & Tick Spray for Dogs and Cats - Drugs.com
Avoid contamination of food and foodstuffs.. HAZARDS TO DOMESTIC ANIMALS. FOR USE ON CATS AND DOGS: Do not apply to dogs or ... Subscribe to Drugs.com newsletters Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, ... Drugs.com Mobile Apps The easiest way to lookup drug information, identify pills, check interactions and set up your own ... Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and ...
Contamination and Cross-Contamination Control Strategy in Shared Facilities for High Potent Products | Pharmaceutical...
The ISPE Drug Shortages Initiative Team conducted a webinar on 9 February 2023 to discuss regulatory and industry insights on ... Contamination and Cross-Contamination Control Strategy in Shared Facilities for High Potent Products. ... Contamination and Cross-Contamination Control Strategy in Shared Facilities for High Potent Products ... Contamination and Cross Contamination Control, Robotics, and Sustainability during the 2-day knowledge exchange and welcome you ...
Cooking utensils and nutrition: MedlinePlus Medical Encyclopedia
Browsing EB144 by Subject
Dangers of Drug-Resistant Bacteria in Our Food
The source wasnt human contamination of the meat at slaughter, or when it was packaged for retail sale." ... Before you reach for that hamburger… Did you know that up to 47% of commercial meat products could contain multi-drug resistant ... 52% of the isolates were resistant to at least three antibiotics that are used commonly in both veterinary and human drug ... On the level of the microbe, studies are finding that they contaminate the environment with drug-resistant bacteria. ...
DailyMed - PROPOFOL injection, emulsion
Do not use if contamination is suspected. Discard unused drug product as directed within the required time limits. There have ... Discard unused drug product. Do not use if contamination is suspected (5.2) ... Common Drugs Used as Premedication or Drugs Used During Anesthesia or Sedation ... 9 DRUG ABUSE AND DEPENDENCE 9.2 Abuse 10 OVERDOSAGE 10.1 Symptoms 10.2 Treatment 11 DESCRIPTION 12 CLINICAL PHARMACOLOGY 12.1 ...
The nitrosamine contamination of drugs, part 3: Quantification of 4-Methyl-1-nitrosopiperazine in rifampicin capsules by LC-MS...
The nitrosamine contamination of drugs, part 3: Quantification of 4-Methyl-1-nitrosopiperazine in rifampicin capsules by LC-MS/ ... The nitrosamine contamination of drugs, part 3: Quantification of 4-Methyl-1-nitrosopipera ... A significant contamination with MeNP was found in all samples, ranging from 0.7 to 5.1 ppm and exceeding the acceptable intake ... Upon emergence of nitrosamines in various drugs, e.g in valsartan, metformin and ranitidine, 4-methyl-1-nitrosopiperazine (MeNP ...
Medicines | Special Issue : Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity
Special Issue in International Journal of Molecular Sciences: Molecular Toxicity of Drugs in Human and Animal Organs. Special ... contamination, and adulteration; and liver histology with its potential contribution to clinical assessment, prognosis, and ... Special Issue in International Journal of Molecular Sciences: Molecular Research on Drug Induced Liver Injury. Special Issue in ... Special Issue in International Journal of Molecular Sciences: Molecular Toxicology of Drug Induced Liver Injury. Special Issue ...
Cross-contaminationBacterialMicrobialWater ContaminationRisksResiduesNitrosamineAntineoplasticPesticidesExposures to hazardous drugsContaminantsHazardousFoodborneBirth defectsHealthcareCompany'sChemotherapy drugsOccurExposureLaboratoryRoutineCommonly2020CulturesSterileResultsOfficialsMedicationsDosesCompoundingPreventionSubstancesFoodCommonRiskLawsuitsSourcesIncludeFirmProtectPotentiallyInjuryInfectionMultipleMarijuanaStopRecentCancer
Cross-contamination3
- Engineering controls are required to protect the preparation from cross-contamination and microbial contamination (if preparation is intended to be sterile) during all phases of the compounding process (Compounding, USP 800). (safehandlingofhazardousdrugs.com)
- Contamination can be introduced through human interaction, cross-contamination with an already infected culture, poor lab techniques, and contaminated raw materials, just to name a few. (corning.com)
- Therefore, everyone is encouraged to have good personal hygiene, use of hand-sanitizers, hand-washing before and after the use of door handles and routine surface disinfection of door handles in order to prevent cross contamination. (who.int)
Bacterial9
- In the United States, bacterial contamination of platelet blood components is well documented and largely a consequence of room temperature storage during their 5-7-day shelf life ( 1 - 3 ). (cdc.gov)
- Published data from active and passive surveillance indicate bacterial contamination of platelet components (1:2,500‒1:5,000) is more frequent than transfusion-transmitted sepsis (1:10,000‒1:100,000) ( 5 ). (cdc.gov)
- Bacterial contamination of platelet components most commonly occurs during blood collection and typically involves either a single identified species of gram-positive bacteria associated with normal skin microflora or, less commonly, gram-negative bacteria from asymptomatic donor bacteremia. (cdc.gov)
- However, multiple episodes of polymicrobial contamination with identical bacterial species in platelet components across different states is exceedingly rare, suggesting a possible common source of contamination. (cdc.gov)
- Strategies to mitigate sepsis risk caused by bacterial contamination of platelets include bacterial cultures incubated before release for transfusion, secondary rapid testing after bacterial culture with a bacterial detection device, and pathogen reduction after platelet collection ( 8 ). (cdc.gov)
- In our group we always use aseptic techniques and fresh media but we still have bacterial contamination, with media turbidity and pH decrease. (corning.com)
- Plasmid profile revealed plasmid fragments in all the bacterial isolates, with most of the isolates, being multi-drug resistant. (who.int)
- The FDA is working closely with officials at the Centers for Disease Control and Prevention and Texas state officials to investigate the cause of these bacterial infections and to determine the scope of the contamination. (medscape.com)
- VIM-GES-CRPA recovered from opened bottles could represent either bacterial contamination during use or during the manufacturing process. (cdc.gov)
Microbial1
- The incidence of foodborne and waterborne diarrhoea is estimated at five episodes of diarrhoea per child per year.4 Due to microbial contamination, introduction of complementary foods is associated with increased diarrhoea.5 The estimated annual mortality rate for diarrhoea in all ages is around 700 000. (who.int)
Water Contamination1
- Baron & Budd is investigating claims of water contamination at the Marine Corps Base Camp Lejeune and Marine Corps Air Station New River in Onslow County in southeastern North Carolina. (baronandbudd.com)
Risks4
- Nevertheless, the extent of contamination is alarming, and countermeasures are needed to minimize public health risks . (bvsalud.org)
- Valisure alerted FDA last year of similar NDMA contamination and cancer risks associated with Zantac. (ashcraftandgerel.com)
- Exposure risks can be greatly reduced by (1) making sure that engineering controls such as a ventilated cabinet are used and (2) using proper procedures and protective equipment for handling hazardous drugs. (cdc.gov)
- Persons exposed only to arsine gas pose no serious risks of secondary contamination to personnel outside the Hot Zone. (cdc.gov)
Residues2
- Personal Protective Equipment (PPE) provides worker protection to reduce exposure to hazardous drug aerosols and residues. (safehandlingofhazardousdrugs.com)
- Outbreaks of cholera, which occurs due to contaminated water, are common in the Region and available data show an upward trend.2,3 Foodborne zoonotic diseases and chemical contamination of food from pesticides and veterinary drug residues are also of concern. (who.int)
Nitrosamine3
- The nitrosamine contamination of drugs, part 3: Quantification of 4-Methyl-1-nitrosopiperazine in rifampicin capsules by LC-MS/HRMS. (bvsalud.org)
- Topics to be addressed include nitrosamines as chemicals present in the environment, in food and, more recently, detected as impurities in drugs, nitrosamine pharmacokinetics, carcinogenesis, mutagenesis, (Q)SAR, and health risk assessment and mitigation. (fda.gov)
- In addition, the panelists will be asked to identify data gaps and research needs to address uncertainties in nitrosamine safety assessment and how to prevent or minimize their presence in drugs. (fda.gov)
Antineoplastic10
- Antineoplastic drugs, also known as anti-cancer drugs or chemotherapy, are used in the treatment of many types of cancer. (cdc.gov)
- Exposure of healthcare workers to antineoplastic drugs from contaminated surfaces and drug vials in hospitals and pharmacies is a continuing problem since the drugs can cause skin problems, birth defects, reproductive issues, and increased risk of various cancers. (cdc.gov)
- CDC researchers at the National Institute for Occupational Safety and Health (NIOSH) developed technology to rapidly detect three commonly used antineoplastic drugs. (cdc.gov)
- The technology is applicable to many types of antineoplastic drugs. (cdc.gov)
- Currently, an estimated 8 million U.S. healthcare workers are potentially exposed to antineoplastic drugs. (cdc.gov)
- Workers prepare, administer, or dispose of antineoplastic drugs when providing chemotherapy to cancer patients. (cdc.gov)
- CDC and the partner's new technology empowers healthcare workers to test surfaces when and where needed - and quickly determine the level of contamination in areas where hazardous antineoplastic drugs are present. (cdc.gov)
- 2016). NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings, 2016. (safehandlingofhazardousdrugs.com)
- Despite the prevention efforts to date, workplace contamination has been well documented by research on a small percentage of antineoplastic, or cancer-killing drugs. (cdc.gov)
- Some classes of drugs are more hazardous than others and, as a group, antineoplastic drugs have been shown in animal studies to be some of the most potent teratogenic agents known, at doses typically used in cancer treatment. (cdc.gov)
Pesticides2
- The production by the Hooker Chemical Company of C-56, the progenitor of many now banned organochlorine pesticides, has resulted in contamination and hardship. (enewspf.com)
- As a result, saliva has been suggested as an alternative biological matrix for the evaluation of a broad range of biomarkers such as environmental contaminants, drugs of abuse, hormones, chemotherapeutics, heavy metals, and pesticides. (cdc.gov)
Exposures to hazardous drugs2
- A containment primary engineering control (C-PEC) is a ventilated device designed and operated to minimize worker and environmental exposures to hazardous drugs by controlling emissions of airborne contaminants (Compounding, USP 800). (safehandlingofhazardousdrugs.com)
- Published studies have shown that workplace exposures to hazardous drugs can cause both acute and chronic health effects such as skin rashes, adverse reproductive outcomes (including infertility, spontaneous abortions, and congenital malformations), and possibly leukemia and other cancers. (cdc.gov)
Contaminants2
- It's the drug manufacturer's responsibility to ensure their medications are safe to use and free from contaminants or defects. (callrainwater.com)
- There are multiple sources of contamination from the environment, and contaminants could enter food during production, harvest, storage, retailing and preparation for consumption. (who.int)
Hazardous16
- Hazardous drugs are transported from the loading dock into the storage area of the hospital pharmacy. (safehandlingofhazardousdrugs.com)
- Transportation of hazardous drugs causes the risk of exposure to all those in close proximity. (safehandlingofhazardousdrugs.com)
- Reducing the Risk of Hazardous Drug Exposure to Health Care Workers. (safehandlingofhazardousdrugs.com)
- Hazardous drugs are stored on shelves in the pharmacy storage unit before they are prepared by the pharmacist. (safehandlingofhazardousdrugs.com)
- For hazardous drug handling outside of drug compounding, the hospital's standard operating procedures (SOP) must describe the appropriate PPE to be worn based on its occupational safety plan and assessment of risk (Personal Protective Equipment, USP 800). (safehandlingofhazardousdrugs.com)
- 2017). USP General Chapter Hazardous Drugs -Handling in Healthcare Settings. (safehandlingofhazardousdrugs.com)
- A hazardous drug is being prepared by compounding in a biological safety cabinet (BSC) by a pharmacist. (safehandlingofhazardousdrugs.com)
- Sterile and nonsterile hazardous drugs must be compounded within a C-PEC located in a C-SEC (Compounding, USP 800). (safehandlingofhazardousdrugs.com)
- In honor of these nurses and all who work with hazardous drugs (many of which are used in the treatment of cancer) we are posting this blog on how to safely prepare, administer or otherwise handle these drugs. (cdc.gov)
- Hazardous drugs can include those used for cancer therapy, some antiviral drugs, hormone agents, and bioengineered drugs. (cdc.gov)
- Reproductive health is one of the most vulnerable end points because many hazardous drugs used for cancer treatment target rapidly dividing cells in the same way teratogens target rapidly dividing embryonic cells. (cdc.gov)
- A complete list of prevention recommendations can be found in the Alert on Hazardous Drugs including detailed recommendation for receiving, storage, preparation and administration of hazardous drugs. (cdc.gov)
- However, while new advances in engineering controls and facility design help to protect workers who mix or compound hazardous drugs, there is not similar protection available for nursing personnel who administer these drugs to patients. (cdc.gov)
- Since the release of the NIOSH Alert on Hazardous Drugs in 2004, nearly 300 papers have been published on hazardous drugs and several new advancements such as CSTDs and robotic systems have come on the market. (cdc.gov)
- When finalized, the Alert will be available on the NIOSH Hazardous Drugs Topic Page . (cdc.gov)
- NIOSH has been updating its list of hazardous drugs every two years based on new FDA drug approvals and new warnings on existing drugs. (cdc.gov)
Foodborne2
- Contamination on farms and in processing facilities from bacteria, such as Salmonella , E. coli , and Listeria are often behind the large foodborne outbreaks and recalls, but food contamination can occur anywhere along the way from the farm to the fork. (cdc.gov)
- As an example of contamination in the kitchen, consider norovirus infection, the most common foodborne illness. (cdc.gov)
Birth defects1
- Studies have shown that prolonged exposure to such chemical contamination can lead to birth defects. (theborneopost.com)
Healthcare5
- This can be the first point of exposure for pharmacists and other healthcare professionals as there could be leakage or traces of the drug on the packaging. (safehandlingofhazardousdrugs.com)
- In that same announcement, the FDA also warned diabetes patients and healthcare providers about the cancer risk associated with NDMA contamination in Metformin. (ashcraftandgerel.com)
- There is also evidence of worker exposure based on measurable amounts of the drugs in the urine of the healthcare workers studied. (cdc.gov)
- The US Food and Drug Administration (FDA) has advised healthcare professionals not to use any sterile products supplied by Specialty Compounding. (medscape.com)
- Patients and healthcare providers should immediately discontinue using EzriCare artificial tears pending additional guidance from CDC and the Food and Drug Administration (FDA). (cdc.gov)
Company's1
- In this video, Dr. Andrea Ballagi, VP Sales and Marketing, Olink Proteomics, shares her thoughts on winning this prized award, why promoting customer success is important for Olink Proteomics and the scientific community, and how the company's technology will help advance future drug discovery. (selectscience.net)
Chemotherapy drugs1
- The resulting tool can analyze samples for doxorubicin and methotrexate (two common chemotherapy drugs) and provide reliable results in less than 10 minutes. (cdc.gov)
Occur3
- Before chemical decontamination can occur, chemical contamination must be recognized. (medscape.com)
- In recent years, reports about Tylenol and combination drugs that contain acetaminophen - from over-the-counter cough syrup to prescription painkillers - suggest that acetaminophen overdose can occur easily and accidentally. (stromlaw.com)
- For example, contamination can occur in the field, or if foods are washed with contaminated water during harvest or processing, or even during preparation. (cdc.gov)
Exposure2
Laboratory4
- Traditional sampling methods to test for surface contamination produce results in several weeks, involve significant expense, and require analysis in a laboratory. (cdc.gov)
- Of the 55 random samples of illegal cannabis pulled from across the county, 84% of products failed official laboratory testing due to contamination. (mercurynews.com)
- Laboratory and cell culture contamination is a serious risk for research labs, process development labs and biomanufacturing. (corning.com)
- Laboratory studies have demonstrated that many chemotherapeutic drugs are teratogenic (can interfere with the development of a fetus), often in more than one animal species. (cdc.gov)
Routine2
- Unfortunately, contamination is a routine threat. (corning.com)
- The contamination was discovered during routine testing by the Food and Drug Administration. (foodsafetynews.com)
Commonly1
- In December 2019, the U.S. Food and Drug Administration (FDA) began an investigation into Metformin, a drug commonly used to treat type-2 diabetes. (ashcraftandgerel.com)
20202
- Upon emergence of nitrosamines in various drugs , e.g in valsartan , metformin and ranitidine , 4-methyl-1-nitrosopiperazine (MeNP) was found in rifampicin in August 2020. (bvsalud.org)
- In April 2020, the FDA asked all manufacturers to recall Zantac (ranitidine) after independent research showed NDMA levels can increase when the drug is exposed to heat. (ashcraftandgerel.com)
Cultures3
- We concluded our Ask the Expert session on how to minimize contamination risk and protect your cultures. (corning.com)
- In addition, contamination isn't always easy to detect, which means that contamination can spread to multiple cultures before the problem is identified. (corning.com)
- With contamination lurking everywhere, it may feel daunting to think about protecting precious cultures. (corning.com)
Sterile1
- Many drugs are supposed to be manufactured in sterile environments. (callrainwater.com)
Results3
- Results of search for 'su:{Drug contamination. (who.int)
- Monterey County District Attorney Jeannine Pacioni joins officials from local and state agencies and departments on Monday to announce the results of a yearlong effort to test illicit cannabis samples pulled from across the county for contamination. (mercurynews.com)
- Contamination can compromise cell culture and experiment results, thus wasting valuable resources conducting experiments that ultimately aren't accurate. (corning.com)
Officials1
- After a year of seizing samples of illicit cannabis from unlicensed cannabis cultivations, clandestine concentrate laboratories and unlicensed distributors, Monterey County officials gathered Monday morning to announce the outcome of testing the collection of products for contamination. (mercurynews.com)
Medications2
- When drugs are used to treat off-label conditions, they may be ineffective or cause dangerous interactions with other medications. (callrainwater.com)
- This is not the first time the FDA has been forced to issue a formal warning about NDMA contamination in common medications. (ashcraftandgerel.com)
Doses1
- If foreign substances come into contact with the area where the drug is manufactured, it can cause contamination that can affect millions of doses. (callrainwater.com)
Compounding1
- During the compounding stage, the drug is out of packaging and exposed to personnel and the environment. (safehandlingofhazardousdrugs.com)
Prevention1
- Sue Nowak is a drug prevention specialist with North Central Health Care, which provides drug counseling, treatment and detoxification services for several northern Wisconsin counties. (twincities.com)
Substances1
- The federal Drug Enforcement Administration is looking into whether the herb belongs on its controlled substances list. (twincities.com)
Food5
- Some drugs are marketed to treat conditions that haven't been approved the U.S. Food and Drug Administration. (callrainwater.com)
- In the United States, a pathogen-reduction device for platelets that uses synthetic psoralen and ultraviolet light to inactivate microorganisms was approved by the US Food and Drug Administration (FDA) in 2014 and adopted voluntarily by some blood establishments. (cdc.gov)
- Only use KI products that have been approved by the Food and Drug Administration (FDA). (cdc.gov)
- The U.S. Food and Drug Administration explains that it infects pigs. (product-reviews.net)
- This study will help them prioritize their efforts on preventing food contamination. (cdc.gov)
Common1
- According to the National Institutes of Health, acetaminophen overdose is one of the most common drug poisonings worldwide. (stromlaw.com)
Risk4
- For this Ask the Expert Session, we assembled a team of experts to answer questions on contamination and minimizing risk. (corning.com)
- The Money Times reports that there is no evidence that PCV1 offers any risk to children - this has not stopped the FDA from asking for a suspension of the drug. (product-reviews.net)
- This year's Scientists' Choice Award for Drug Discovery & Development Article of the Year went to an interview with Prof. Leo A. B Joosten, Radboudumc, detailing how Olink Proteomics multiplex immunoassay technology enabled identification of biomarkers to predict patient risk of COVID-19. (selectscience.net)
- The FDA believes that use of these products would create an unacceptable risk for patients," Janet Woodcock, MD, director of the FDA's Center for Drug Evaluation and Research, said. (medscape.com)
Lawsuits1
- At Ashcraft & Gerel, our attorneys have been leaders in this area for more than 65 years and have successfully won verdicts in many defective drug lawsuits. (ashcraftandgerel.com)
Sources2
- [ 2 ] Any plan must include contingencies for contamination sources within the hospital and for ED evacuation. (medscape.com)
- Experts discussed spotting and eliminating sources of contamination, including testing raw materials and in-process testing strategies. (corning.com)
Include1
- The workshop will include presentations on nitrosamines chemistry and toxicology and, on the finding of nitrosamines as impurities in drugs. (fda.gov)
Firm2
- The Little Rock drug injury lawyers at our firm are dedicated to one thing: helping injured victims like you move forward with their lives. (callrainwater.com)
- The personal injury attorneys at the Strom Law Firm, based in Columbia, SC, are now investigating and evaluating cases against Tylenol®, the popular Acetaminophen drug . (stromlaw.com)
Protect1
- At Rainwater, Holt & Sexton, our Arkansas drug injury lawyers fight to protect patients like you from negligent drug manufacturers. (callrainwater.com)
Potentially1
- severe ED contamination may necessitate departmental closure, which is potentially catastrophic in a mass casualty incident. (medscape.com)
Injury1
- We'll do everything in our power to investigate your drug injury claim and build a strong case against the manufacturer. (callrainwater.com)
Infection1
- Giving a patient a contaminated injectable drug could result in a life-threatening infection. (medscape.com)
Multiple1
- Often cabinets and incubators can be a source of contamination since these are often shared among multiple people/research groups. (corning.com)
Marijuana1
- Marijuana and non-medical use of prescription drugs remain the most popular forms of drug abuse, she said. (twincities.com)
Stop1
- As a first step, the FDA has asked doctors to stop prescribing combination drugs with more than 325 mg of acetaminophen. (stromlaw.com)
Recent1
- Discuss the recent drug contamination with nitrosamines. (fda.gov)
Cancer1
- In addition, there are numerous new drugs that have been approved for cancer treatment. (cdc.gov)