Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
The action of a drug in promoting or enhancing the effectiveness of another drug.
Therapy with two or more separate preparations given for a combined effect.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173)
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).
The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
A cell line derived from cultured tumor cells.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
6-(Methylthio)-9-beta-D-ribofuranosylpurine. An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position.
A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
Phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy.
One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic.
A generic name for film produced from wood pulp by the viscose process. It is a thin, transparent sheeting of regenerated cellulose, moisture-proof and sometimes dyed, and used chiefly as food wrapping or as bags for dialysis. (Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few side effects.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Tailored macromolecules harboring covalently-bound biologically active modules that target specific tissues and cells. The active modules or functional groups can include drugs, prodrugs, antibodies, and oligonucleotides, which can act synergistically and be multitargeting.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A 4-aminoquinoline compound with anti-inflammatory properties.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
Inorganic or organic compounds that contain the basic structure RB(OH)2.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A family of diphenylenemethane derivatives.
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.
The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
Tests that demonstrate the relative effectiveness of chemotherapeutic agents against specific parasites.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Compounds that include the amino-N-phenylamide structure.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
Substances that reduce the growth or reproduction of BACTERIA.
An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE.
Simultaneous resistance to several structurally and functionally distinct drugs.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.
Substances that are destructive to protozoans.
The process of finding chemicals for potential therapeutic use.
Elements of limited time intervals, contributing to particular results or situations.
Organic salts and esters of benzenesulfonic acid.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
A pyrazine that is used therapeutically as an antitubercular agent.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
A class of weak acids with the general formula R-CONHOH.
Antimetabolites that are useful in cancer chemotherapy.
A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Heterocyclic rings containing three nitrogen atoms, commonly in 1,2,4 or 1,3,5 or 2,4,6 formats. Some are used as HERBICIDES.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
A family of hexahydropyridines.
Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
Benzene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.
Agents that inhibit PROTEIN KINASES.
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
An organoplatinum compound that possesses antineoplastic activity.
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
A group of compounds that contain the structure SO2NH2.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.
Compounds with a BENZENE fused to IMIDAZOLES.
Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.
The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
Tumors or cancer of the human BREAST.
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
Tumors or cancer of the LUNG.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
The giving of drugs, chemicals, or other substances by mouth.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Established cell cultures that have the potential to propagate indefinitely.
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An anti-inflammatory 9-fluoro-glucocorticoid.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
The observable response an animal makes to any situation.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Antibodies produced by a single clone of cells.
The return of a sign, symptom, or disease after a remission.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A malignant epithelial tumor with a glandular organization.
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The rate dynamics in chemical or physical systems.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

Persistent damage to Enterocytozoon bieneusi, with persistent symptomatic relief, after combined furazolidone and albendazole in AIDS patients. (1/7446)

AIM: To investigate morphological changes in Enterocytozoon bieneusi and the duration of symptomatic relief after combination treatment with furazolidone and albendazole in AIDS patients. METHODS: Four severely immunocompromised AIDS patients with symptomatic E bieneusi infection of the gut received an 18 day course of combined furazolidone and albendazole (500 + 800 mg daily). All patients were monitored for parasite shedding in stool by light microscopy at the end of treatment and monthly during follow up. At the end of treatment, duodenal biopsy specimens obtained from three patients were studied by transmission electron microscopy by two pathologists blind to the patients' treatment or clinical outcome. Duodenal biopsy specimens obtained from one of the patients two months after completion of treatment were also studied electronmicroscopically. RESULTS: All patients had long lasting symptomatic relief, with a major decrease--or transient absence--of spore shedding in stools from completion of treatment. After treatment, changes in faecal spores were persistently found by light microscopy in all cases, and there was evidence of both a substantial decrease in the parasite load and ultrastructural damage in the parasite in all biopsy specimens. The treatment was well tolerated, and no patient had clinical or parasitological relapse during follow up (up to 15 months). CONCLUSIONS: The long lasting symptomatic relief observed in all four treated patients correlated with the persistent decrease in parasite load both in tissue and in stool, and with the morphological changes observed in the life cycle of the protozoan. These data suggest that combined treatment with furazolidone and albendazole is active against E bieneusi and may result in lasting remission even in severely immunocompromised patients.  (+info)

Emergent immunoregulatory properties of combined glucocorticoid and anti-glucocorticoid steroids in a model of tuberculosis. (2/7446)

In Balb/c mice with pulmonary tuberculosis, there is a switch from a protective Th1-dominated cytokine profile to a non-protective profile with a Th2 component. This switch occurs while the adrenals are undergoing marked hyperplasia. Treatment with the anti-glucocorticoid hormones dehydroepiandrosterone or 3 beta, 17 beta-androstenediol, during the period of adrenal hyperplasia, maintains Th1 dominance and is protective. We investigated the effects of these hormones as therapeutic agents by administering them from day 60, when the switch to the non-protective cytokine profile was already well established. Given at this time (day 60), doses that were protective when given early (from day 0) were rapidly fatal. A physiological dose of the glucocorticoid corticosterone was also rapidly fatal. However when the corticosterone and the anti-glucocorticoid (AED or DHEA) were co-administered, there was protection, with restoration of a Th1-dominated cytokine profile, enhanced DTH responses, and enhanced expression of IL-1 alpha and TNF alpha. Therefore this combination of steroids has an emergent property that is quite unlike that of either type of steroid given alone. It may be possible to exploit the ant-inflammatory properties of glucocorticoids while preserving a Th1 bias, by combining glucocorticoids with DHEA or suitable metabolites.  (+info)

Precocious estrus and reproductive ability induced by PG 600 in prepuberal gilts. (3/7446)

A total of 29 SPF Large White prepuberal gilts (mean age 152 days at treatment) were examined for estrous and ovulatory responses after PG 600 treatment. After treatment, 85.2% of the gilts showed standing estrus within 6 days. Whereas the treatment-to-estrus interval and duration were 3.7 and 1.9 days respectively. As ovulation occurred on Day 5 to 6, appropriate timing of artificial insemination would be about 4 days after treatment. Fertility of gilts revealed to be excellent, giving rise to a high percentage of normal embryos, 85.3%. Meanwhile, development and growth of fetuses were mostly normal. Other reproductive performances recorded were: mean litter size 6.8; mean birth weight 1.26 kg; weaning-to-return estrus interval 5 to 8 days. In conclusion, PG 600 was found to be useful in inducing fertile estrus in prepuberal gilts, a result which will be of interest for commercial pig farms.  (+info)

Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation. (4/7446)

Although young mice homozygous for the osteopetrosis (op) mutation usually developed prominent osteopetrosis, its severity was markedly reduced in aged op/op mice. This age-associated reversal of osteopetrosis was accompanied by the expansion of bone marrow cavities and increased numbers of tartrate-resistant acid phosphatase (TRAP)-positive cells and of macrophages in the bone marrow. The TRAP-positive cells were mononuclear and developed ruffled borders and numerous vesicles, vacuoles, and granules. Enzyme-linked immunosorbent assay demonstrated a significant elevation of serum granulocyte/ macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-3 levels in the aged op/op mice. To examine whether GM-CSF and/or IL-3 could correct osteopetrosis in young op/op mice, 5 ng of recombinant murine (rm)GM-CSF and/or 100 ng of rmIL-3 were injected daily into young op/op mice. In these treated young op/op mice, the bone marrow cavities were expanded significantly at 2 weeks after administration, associated with significantly increased numbers of TRAP-positive cells and bone marrow macrophages. TRAP-positive cells increased in number with days after injection. These results suggest that GM-CSF and IL-3 induce the development of osteoclasts to correct osteopetrosis in the op/op mice with aging.  (+info)

Transforming growth factor-alpha acting at the epidermal growth factor receptor reduces infarct volume after permanent middle cerebral artery occlusion in rats. (5/7446)

Transforming growth factor-alpha (TGF-alpha) is a ligand for the epidermal growth factor (EGF) receptor (EGFR), and is more abundant than EGF in the brain. The authors studied whether administration of exogenous TGF-alpha into the brain can protect neurons against ischemia in a model of permanent middle cerebral artery (MCA) occlusion in the rat, and whether any effect of TGF-alpha was mediated by EGFR by administering 4,5-dianilinophthalimide (DAPH), a protein-tyrosine kinase inhibitor with high selectivity for EGFR. Rats received either TGF-alpha (10 or 25 ng), DAPH (100 ng), DAPH plus TGF-alpha (25 ng), or vehicle in the ipsilateral first ventricle. Drugs were administered twice: 30 minutes before and 30 minutes after MCA occlusion, and infarct volume was evaluated 24 hours later. Transforming growth factor-alpha at the dose of 25 ng caused a statistically significant reduction of infarct volume (60%) in relation to ischemic rats administered vehicle. This reduction was no longer seen when TGF-alpha was administered in combination with DAPH. The present results show that TGF-alpha can protect neurons from ischemic damage, and that this effect is mediated by EGFR. It is suggested that activation of EGFR-mediated intracellular signalling pathways contributes to the survival of neural cells susceptible to ischemic injury.  (+info)

Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine. (6/7446)

Morphine (Mor) tolerance has been attributed to a reduction of opioid-adrenergic antinociceptive synergy at the spinal level. The present experiments tested the interaction of intrathecally (i.t.) administered Mor-clonidine (Clon) combinations in mice made acutely or chronically tolerant to Mor. ICR mice were pretreated with Mor either acutely (40 nmol i.t., 8 h; 100 mg/kg s.c., 4 h) or chronically (3 mg/kg s.c. every 6 h days 1 and 2; 5 mg/kg s.c. every 6 h days 3 and 4). Antinociception was detected via the hot water (52.5 degrees C) tail-flick test. After the tail-flick latencies returned to baseline levels, dose-response curves were generated to Mor, Clon, and Mor-Clon combinations in tolerant and control mice. Development of tolerance was confirmed by significant rightward shifts of the Mor dose-response curves in tolerant mice compared with controls. Isobolographic analysis was conducted; the experimental combined ED50 values were compared statistically against their respective theoretical additive ED50 values. In all Mor-pretreated groups, the combination of Mor and Clon resulted in significant leftward shifts in the dose-response curves compared with those of each agonist administered separately. In all tolerant and control groups, the combination of Mor and Clon produced an ED50 value significantly less than the corresponding theoretical additive ED50 value. Mor and Clon synergized in Mor-tolerant as well as in control mice. Spinally administered adrenergic/opioid synergistic combinations may be effective therapeutic strategies to manage pain in patients apparently tolerant to the analgesic effects of Mor.  (+info)

Persistent induction of apoptosis and suppression of mitosis as the basis for curative therapy with S-1, an oral 5-fluorouracil prodrug in a colorectal tumor model. (7/7446)

In an effort to improve the therapeutic selectivity of 5-fluorouracil (FUra) against colorectal cancer, S-1, a combination agent including a prodrug of FUra with two modulators, was recently developed by Taiho Pharmaceuticals Co. S-1 is a combination of tegafur (FT), 5-chloro-2,4-hydroxypyridine, and potassium oxonate in the molar ratio of 1.0:0.4:1.0, with the latter two components as inhibitors of dihydropyrimidine dehydrogenase and phosphoribosylpyrophosphate transferase, respectively. In this study, the therapeutic selectivity and efficacy of S-1 (oral) was compared with FT (oral) and FUra (i.v. infusion) in rats bearing advanced colorectal cancer by using clinically relevant schedules. The maximum tolerated doses (MTDs) of S-1, FT, and FUra were 31.5, 200, and 25 mg/kg/d for 7 days and 22.5, 150, and 12.5 mg/kg/d for 28 days, respectively. The therapeutic index of S-1 was 4- to 5-fold higher than that of either FT or FUra. S-1 achieved 100% complete tumor regression (CR) at its MTD in both 7-day and 28-day schedules. Furthermore, the high incidences of stomatitis, alopecia, and diarrhea observed with FUra and FT, were not observed with S-1. In an attempt to understand the basis for the observed superior therapeutic selectivity with S-1, we studied pharmacokinetic analysis of FUra, drug-induced apoptosis, suppression of mitosis, and inhibition of thymidylate synthase (TS) after S-1, FUra, or FT administration. The peak plasma FUra concentrations derived from FUra or S-1 (FT) at comparable MTDs were similar, but the plasma level of FUra was higher with S-1 than with FUra. Induction of high and sustained apoptosis was achieved with S-1. Although the initial level of apoptosis induced by FUra was comparable to S-1, it was not sustained. The sustained level of apoptosis appears to correlate with tumor growth inhibition. Mitotic figures were more greatly suppressed with S-1 treatment than with FUra. Studies on TS inhibition indicated that, although both S-1 and FUra caused a 4- to 6-fold induction of total TS protein, single oral administration of S-1 was superior to 24-h infusion of FUra in suppressing free TS. The data are consistent with the observation that the therapeutic efficacy of S-1 (100% cure) over FUra is associated with high and sustained levels of drug-induced apoptosis, greater suppression of mitosis, and inhibition of free TS in tumor tissues.  (+info)

Growth hormone-releasing peptide-2 infusion synchronizes growth hormone, thyrotrophin and prolactin release in prolonged critical illness. (8/7446)

OBJECTIVE: During prolonged critical illness, nocturnal pulsatile secretion of GH, TSH and prolactin (PRL) is uniformly reduced but remains responsive to the continuous infusion of GH secretagogues and TRH. Whether such (pertinent) secretagogues would synchronize pituitary secretion of GH, TSH and/or PRL is not known. DESIGN AND METHODS: We explored temporal coupling among GH, TSH and PRL release by calculating cross-correlation among GH, TSH and PRL serum concentration profiles in 86 time series obtained from prolonged critically ill patients by nocturnal blood sampling every 20 min for 9 h during 21-h infusions of either placebo (n=22), GHRH (1 microg/kg/h; n=10), GH-releasing peptide-2 (GHRP-2; 1 microg/kg/h; n=28), TRH (1 microg/kg/h; n=8) or combinations of these agonists (n=8). RESULTS: The normal synchrony among GH, TSH and PRL was absent during placebo delivery. Infusion of GHRP-2, but not GHRH or TRH, markedly synchronized serum profiles of GH, TSH and PRL (all P< or =0.007). After addition of GHRH and TRH to the infusion of GHRP-2, only the synchrony between GH and PRL was maintained (P=0.003 for GHRH + GHRP-2 and P=0.006 for TRH + GHRH + GHRP-2), and was more marked than with GHRP-2 infusion alone (P=0.0006 by ANOVA). CONCLUSIONS: The nocturnal GH, TSH and PRL secretory patterns during prolonged critical illness are herewith further characterized to include loss of synchrony among GH, TSH and PRL release. The synchronizing effect of an exogenous GHRP-2 drive, but not of GHRH or TRH, suggests that the presumed endogenous GHRP-like ligand may participate in the orchestration of coordinated anterior pituitary hormone release.  (+info)

ABSTRACT. In India. Fixed Dose Combinations(FDCs) have drawn the attention of health service providers and the service recipients. Therefore, the development of fixed dose combinations (FDCs) is becoming increasingly important from a public health perspective. The objective was to study the prescribing pattern and to assess the rationality of fixed dose combinations using seven point criteria. During the study period a total of 100 patients were enrolled based on inclusion and exclusion criteria. The study population includes an overall 56% male with an average age of 46.15 ± 19.33 years. A total of 538 drugs were prescribed to the patient with a mean of 5.38±5.77.The major therapeutic category of drugs prescribed were antibiotics (30.03%), antihypertensives (12.63%) and others (13.01%).The study population had 130 FDCs in which again antibiotics topped the list, followed by Anti-diabetics. Among these 92 contributed to antibiotic FDCs belonging to 15 different groups. The average interaction ...
TB, HIV and Malaria are three major infectious diseases of global health importance where predefined combinations of drugs is standard recommendation for treatment. For example, for drug sensitive TB the recommended treatment is a four-drug combination of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol for two months, followed by 4 months of Isoniazid and Rifampicin (2HRZE/4HR). For multidrug-resistant TB, recommendations include six drugs for 4-6 months followed by four drugs during 5 months. Similarly, HIV is treated with a combination of four antiretrovirals and Malaria is treated with combinations with Artemisin. In these cases fixed dose combinations are recommended in the World Health Organization (WHO) treatment guidelines, and several generics have been pre-qualified by WHO as well.. As the treatment periods are long with several drugs, recommendations include using fixed dose combinations or daily dose bags to improve compliance to treatment. This has indeed been a very important ...
The purpose of this study is to compare the safety and pharmacokinetics between co-administration and fixed dose combination of DWC20155 and DWC20156 in
This trial will compare the efficacy of fixed combination levamlodipine/telmisartan with levamlodipine in patients with stage 2 hypertension. The primary
Pharmacokinetic (PK) Parameter: AUCtau of SOF, its Major Metabolite (GS-331007), VEL and VOX. [ Time Frame: Cohorts 1 and 2 (6 to , 18 years of age): predose, 0.5, 1, 2, 3, 4, 6, 8, and 12 hours postdose at Week 2 or 4; Cohort 3 (3 to , 6 years of age): predose, 0.5, 1, 2, 3, 4, 8, and 12 hours postdose at Week 2 or 4 ...
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The UNITY study has introduced the promising new drug combination of umbralisib plus ublituximab as a CLL treatment option. Learn more!
This eMedTV segment wraps up this look at drugs that may interfere with Loryna, such as protease inhibitors. However, because not all interactions may have been included in this article, this page reminds readers to discuss the issue with their doctor.
Learn about how drug mixing can heighten the effects of the individual drugs as well as contribute to the development of additional health issues.
Serious Adverse Events are reported by treatment group (Combination/Tablet+Capsule [N=38] or Tablet+Capsule/Combination [N=39]). For Other Adverse Events, the Combination/Tablet+Capsule group includes all subjects who received Combination Tablet (N=76) and the Tablet+Capsule/Combination group includes all subjects who received Tablet+Capsule (N=77 ...
PubMed journal article: The Bioequivalence and Effect of Food on the Pharmacokinetics of a Fixed-Dose Combination Tablet Containing Rosuvastatin and Ezetimibe in Healthy Japanese Subjects. Download Prime PubMed App to iPhone, iPad, or Android
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Fixed-dose combination drugs have been used for some time in certain therapeutic categories such as antihypertensives, although they were often reserved for second- or third-line therapy. With the revolution in the survival rates of patients suffering from human immunodeficiency virus (HIV) infection that occurred with the implementation of fixed-drug combination products for this, this delivery technology received a boost of confidence as well as an influx of creative applications to other diseases. For the past several years, a number of fixed-dose combination drugs have been introduced for a variety of diseases, some for the first time in a particular disease category. With this in mind, this STIX Market Research report focuses on the impact of fixed-dose combination drug technology on various therapeutic categories, as well as providing assessments and projections of this technology overall and the impact on the patient compliance and effectiveness.. Specifically the aim of this report is to ...
A phase III trial for the fixed-combination netarsudil/latanoprost agent (Roclatan, Aerie Pharmaceuticals)reports positive results. The company plans to submit a NDA for the drug in early 2018.
U.S. Food & Drug Administration (FDA), April 5, 2016.. On April 4, 2016 FDA approved DESCOVY, a two-drug fixed dose combination tablet containing 2 HIV nucleoside analog reverse transcriptase inhibitors (NRTIs), emtricitabine (FTC) and tenofovir alafenamide (TAF). Each DESCOVY tablet contains 200 mg of FTC and 25 mg of TAF (equivalent to 28 mg of tenofovir alafenamide fumarate).. DESCOVY is not a complete regimen for the treatment of HIV-1 infection and must be combined with other antiretroviral agents to form a complete regimen.. The approval is based on a relative bioavailability trial demonstrating FTC and TAF exposures were similar between DESCOVY and GENVOYA (elvitegravir/cobicistat/FTC/TAF). A clinical trial to evaluate the efficacy and safety of DESCOVY was not required because the safety and efficacy of FTC and TAF was established previously in clinical trials with GENVOYA.. TAF 25 mg provides for TAF exposures that match or exceed those observed in patients receiving GENVOYA, ensuring ...
wp-content/uploads/2014/11/clear-box.png 0 0 admin /wp-content/uploads/2014/11/clear-box.png admin2014-08-13 20:29:332014-12-09 02:37:05The Oupicky lab received a new NIH R01 grant on combination drug/siRNA delivery ...
How is Diazepam and Methohexital (drug combination) abbreviated? D-M stands for Diazepam and Methohexital (drug combination). D-M is defined as Diazepam and Methohexital (drug combination) very rarely.
Fixed-dose drug combinations are used to treat conditions like Parkinson s, HIV, malaria and tuberculosis, but these drugs lack approval and could put patients lives at risk.
Today the norm in modern cancer treatment is to use different forms of drug combinations. Recently anti-cancer treatment using drug combinations has gained increased attention due to the outstanding pharmacotherapeutic opportunities provided by combination therapies. However, the potential of this field is largely unexplored, partly due to the complexities associated with the astronomical number of possible combinations and partly due to the lack of means for quantifying clinically relevant adverse side effects in the early stages of the combination discovery and development process. This has resulted in relatively limited progress in this area. Motivated by this unfortunate state-of-affairs, the research reported in this thesis was aimed at developing and implementing computational and experimental methods to facilitate and accelerate the discovery and development of anti-cancer therapies. In paper I, the largely overlooked concept of therapeutic synergy is re-introduced and demonstrated to be ...
Thousands of fixed dose combination (FDC) drugs - where two or more drugs are combined in a set ratio in a single dose form, usually a tablet or capsule - are formulated, made and sold within India.
These so-called epigenetic therapy drugs, used together, achieved robust anti-tumor responses in human cancer cell lines and mice.
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The extracellular matrix (ECM) is a complex material that serves to stabilize tissues, promote cell attachment, and modulate cell functionality by specifically interacting with cell surface receptors. This material has been shown to play structural, bioch...
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Since Gilead is the most active sponsor, it follows that one of their drugs also tops the list of most commonly evaluated compounds. However, its interesting that the already approved sofosbuvir (SOF) is evaluated in 44 ongoing trials (Figure 3) while Gilead is only involved in 33 (Figure 2). SOF, which is already quite successful as the approved Sovaldi®, continues to undergo evaluation with other compounds from Gilead as well as in combination with drugs from other sponsors. Most SOF trials are Gilead sponsored and evaluate the drug as a fixed dose combination (FDC) with ledipasvir as the already approved combination known as Harvoni® or with the yet unnamed GS-5816. Some examples where SOF is co-administered with drugs from other sponsors include Mercks studies with their FDC of elbasvir + grazoprevir and BMS with their FDC of asunaprevir + daclatasvir + beclabuvir (data not shown).. FDCs continue to be of high interest for various reasons. They minimize the pill burden for patients to ...
Click to launch & play an online audio visual presentation by Prof. Ying Yuan on Design early phase drug combination trials: methods, part of a collection of online lectures.
Atazanavir (ATV) (or Reyataz) is generally used in combination with the boosting agent, ritonavir (ATV/r), and is currently being developed as a fixed-dose combination with the boosting agent cobicistat (ATV/cobi).
sciencehabit writes Pharmaceuticals often have side effects that go unnoticed until theyre already available to the public. Doctors and even the FDA have a hard time predicting what drug combinations will lead to serious problems. But thanks to people scouring the web for the side effects of the d...
In the first clinical trial in humans, researchers test a promising drug combination that could help fight the effects of cellular aging.
The abortion pill RU-486 has claimed two more lives, as informed by regulators who issued a warning that brought renewed calls for pulling the drug combination from the market.
Most study participants fulfilled ACR criteria for knee osteoarthritis,10 illustrating that this is a common and underdiagnosed condition within the community. The use of two combination tablets of ibuprofen/paracetamol was associated with significant improvements in pain relief, function and patient quality of life compared with paracetamol monotherapy for both short and long-term use. A significantly greater proportion of patients taking two combination tablets were responders at day 10 compared with paracetamol monotherapy, but not at study end. The level of absolute pain reduction achieved with one or two combination tablets was modest but of an order considered clinically relevant.32 33 The dose of ibuprofen used in this study was moderate, reflecting the non-prescription dose, the observed improved efficacy with the combination could therefore be due to paracetamol adding further cyclooxygenase inhibition to that provided by ibuprofen alone.. This combination tablet is designed for ...
Clinical trial: Crossover Study to Evaluate the Comparative Bioavailability of Two Fixed Dose Combination Tablet Formulations of Extended Release Metformin and Extended Release Glimepiride in Health Volunteers
The World Health Organization (WHO) recommends artemisinin combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria. The present study investigated the efficacy and safety of fixed dose combination (FDC) of arterolane maleate 37.5 mg and piperaquine phosphate (PQP) 187.5 mg dispersible tablets in paediatric patients aged 6 months to 12 years. Male and female patients aged 6 months to 12 years who were confirmed cases of P. falciparum mono-infection with fever or documented history of fever in the previous 24 h were included. The patients were administered FDC of arterolane maleate and PQP as single daily doses for three consecutive days based on their age. The primary efficacy outcome was proportion of patients with polymerase chain reaction (PCR)-corrected adequate clinical and parasitological response (ACPR) on day 28. Safety was analysed based on adverse events (AE), laboratory abnormalities and abnormalities on electrocardiograph. A total of 141 eligible paediatric
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BACKGROUND: The fixed-dose combination of any two antihypertensive drugs from different drug classes is typically more effective in reducing blood pressure than a dose increase of component monotherapy. We assessed the efficacy and safety of a fixed-dose combination of a vasodilating β blocker (nebivolol) and an angiotensin II receptor blocker (valsartan) in adults with hypertension.. METHODS: We did an 8-week, phase 3, multicentre, randomised, double-blind, placebo-controlled, parallel-group trial at 401 US sites. Participants (age ≥18 years) with hypertension but with blood pressure less than 180/110 mm Hg were randomly assigned (2:2:2:2:2:2:2:1) by a 24-h interactive web response system in blocks of 15 to 4 weeks of double-blind treatment with nebivolol and valsartan fixed-dose combination (5 and 80 mg/day, 5 and 160 mg/day, or 10 and 160 mg/day), nebivolol (5 mg/day or 20 mg/day), valsartan (80 mg/day or 160 mg/day), or placebo. Doses were doubled in weeks 5-8; results are reported ...
Sulfadoxine-Pyrimethamine Indo Farma is a medicine available in a number of countries worldwide. A list of US medications equivalent to Sulfadoxine-Pyrimethamine Indo Farma is available on the website.
If all three of the above are present a combination product delivering a twice-daily dose of 100 micrograms of fluticasone and 50 micrograms of salmeterol can be used for initial treatment. This is equivalent to two doses twice a day of the pMDI and one dose twice a day of the DPI. If any of the criteria above are not present a standard inhaled corticosteroid, for example beclometasone, should be used for initial treatment.. Once control is attained with the approach outlined above treatment should be reviewed and consideration given to stepping down to an inhaled corticosteroid alone in place of the combination product.. Action: Healthcare professionals should be aware of this change. This combination can be used to rapidly control asthma in suitable patients but treatment should be reviewed and stepped down once control is achieved.. ...
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respectively. The MAA for F/TAF is supported by data from Phase 3 clinical studies evaluating the safety and efficacy of E/C/F/TAF for the treatment of HIV-1 infection among treatment-naïve adults, in which the F/TAF-based regimen (administered as E/C/F/TAF) resulted in non-inferior efficacy and improved renal and bone laboratory parameters as compared to F/TDF-based therapy (administered as E/C/F/TDF or Stribild®). The MAA is also supported by data from additional Phase 3 studies evaluating the F/TAF-based regimen (administered as E/C/F/TAF) among virologically suppressed adults who switched regimens and adults with mild-to-moderate renal impairment. Lastly, bioequivalence studies demonstrated that the formulation of the fixed-dose combinations of F/TAF achieved the same drug levels in the blood as in E/C/F/TAF. Review of the MAA will be conducted by the EMA under the centralized procedure, which, when finalized, may lead to the grant of marketing authorization by the ...
To evaluate perindopril 3.5 mg/amlodipine 2.5 mg once daily, a novel fixed-dose combination adapted for first-step treatment in patients with hypertension. This fixed dose had to be equivalent to amlodipine 5 mg in terms of blood pressure effic
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Author(s): Renslo, Adam; Mott, BT; Eastman, RT; Guha, R; Sherlach, KS; Siriwardana, A; Shinn, P; McKnight, C; Michael, S; Lacerda-Queiroz, N; Patel, PR | Abstract: Drug resistance in Plasmodium parasites is a constant threat. Novel therapeutics, especially new drug combinations, must be identified at a faster rate. In response to the urgent need for new antimalarial drug combinations we screened a large collection of
Generic Amlodipine & Losartan Combination tablets are used for treating hypertension, high blood pressure and heart diseases. Order more than 30 tablets at our pharmacy and save upto $26.40 at .
US regulators have rejected Schering-Plough and Merck & Cos bid to get approval for a combination tablet of the firms big-selling Claritin and Singulair. - News - PharmaTimes
Quinine is a prescription drug used to treat uncomplicated (or mild) malaria. This eMedTV page offers more information on quinine, explaining the drugs dosing guidelines, possible side effects, and what your doctor needs to know prior to treatment.
WASHINGTON -- An investigational single-pill regimen for HIV -- the first to be based on a protease inhibitor -- was less toxic than a similar regimen using separate drugs, a researcher said.
Before deciding to treat uncomplicated appendicitis with antibiotics, all of the options should be mentioned as part of the shared decision-making process.
NEW YORK (Reuters Health) - Outcomes among tuberculosis patients treated with a fixed-dose combination of four drugs are similar to those in patients treated with the same four drugs given separately, an international team reports in the Journal of the American Medical Association for April 13. The researchers explain that fixed-dose...
5592 Abstract Although a number of methods for assessing drug interactions are available, most methods lack a means of selecting combinations of doses efficiently in planning such experiments. The power-maximized design, derived based on the uniform measures of all possible dose combinations of interest, is able to select the drug combinations (doses of each constituent drug) and to determine the required number of replicates at each combination in order to detect synergy, additivity or antagonism, with pre-specified statistical power for the experiment. An F-test is proposed to detect departures from additivity for combinations of two drugs. To explore the joint effect of the combination, a 3-dimensional combination index surface characterizes the interaction of a two-drug combination estimated using the B-splines. Synergism is manifested as a substantial drop in the combination index which is a 2-dimensional slice of the combination index surface. These methods were applied to evaluate SAHA ...
In a move that could lead to a new milestone for treatment in the evolution of the worldwide AIDS epidemic, a Food and Drug Administration (FDA) panel ...
Hello and thanks for posting. Yes, it can be entirely appropriate to change the dose or dose frequency of medications for people with kidney disfunction. Fixed dose combinations, like Epzicom...
If one were taking over-the-counter fish oil to achieve all the benefits of Omega-3s, would a better choice be the prescription fish oil, Omacor? Cost is not a factor, nor is lowering triglycerides. Th...
Preventative Bioregulatory Medicine strengthens health and prevents the advancement of disease. It treats constitutional and acquired weaknesses by addressing multiple self-regulating psychological and physiological mechanisms.
Bristol Myers Squibb (NYSE BMY) today announced primary results from the Phase 2 3 RELATIVITY-047 (CA224-047) trial evaluating the fixed-dose combination of rel
The fixed-dose combination of sacubitril and valsartan has been approved since November 2015 for adults with symptomatic chronic heart failure with reduced pump function.
This page contains brief information about the drug combination called PAD. The drugs in the combination are listed, and links to individual drug summaries are included.
This page contains brief information about the drug combination called CHLORAMBUCIL-PREDNISONE. The drugs in the combination are listed, and links to individual drug summaries are included.
Combination with other drugs[edit]. A confounding factor in cannabis research is the prevalent usage of other recreational ... Public opinion on drugs and drug policy Archived 2014-07-15 at the Wayback Machine.. Transform Drug Policy Foundation: Fact ... Lisbon: European Monitoring Centre for Drugs and Drug Addiction. doi:10.2810/13807. ISBN 978-92-9168-312-3.. [page needed] ... "Information on Drugs of Abuse". Commonly Abused Drug Chart. 2018-07-02.. ...
J04AM Combinations of drugs for treatment of tuberculosis[edit]. J04AM01 Streptomycin and isoniazid. J04AM02 Rifampicin and ... J04B Drugs for treatment of lepra[edit]. J04BA Drugs for treatment of lepra[edit]. J04BA01 Clofazimine. J04BA02 Dapsone. ... "WHO Collaborating Centre for Drug Statistics Methodology.. *^ "ATCvet Index 2018: code QJ04". WHO Collaborating Centre for Drug ... 2 J04B Drugs for treatment of lepra *2.1 J04BA Drugs for treatment of lepra ...
Combination drugs[edit]. Some of the DPP-4 inhibitor drugs have gotten approval from the FDA to be used with metformin ... Oral anti-diabetic drugs, insulins and insulin analogs, and other drugs used in diabetes (A10) ... "Pancreatic Safety of Incretin-Based Drugs - FDA and EMA Assessment - NEJM".. *^ Monami M, Dicembrini I, Mannucci E (January ... FDA has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl ...
"WHO Collaborating Centre for Drug Statistics Methodology.. *^ "ATCvet Index 2018: code QA16". WHO Collaborating Centre for Drug ... QA16QA52 Sodium propionate, combinations. References[edit]. *^ "ATC/DDD Index 2018: code A16". ... QA16AA51 Levocarnitine, combinations. A16AB Enzymes[edit]. A16AB01 Alglucerase. A16AB02 Imiglucerase. A16AB03 Agalsidase alfa. ... QA16QA Drugs for prevention and/or treatment of acetonemia[edit]. QA16QA01 Propylene glycol. QA16QA02 Sodium propionate. ...
Sigmamycine was a combination drug of oleandomycin and tetracycline that was supported by a major marketing campaign. It was in ... Podolsky SH, Greene JA (August 2011). "Combination drugs--hype, harm, and hope". The New England Journal of Medicine. 365 (6): ... By the early 1970s, Pfizer's combination drugs were withdrawn from the market. Oleandomycin is a bacteriostatic agent. Like ... Public interest in oleandomycin peaked when Pfizer introduced the combination drug Sigmamycine into the market in 1956. ...
R03AH Combinations of adrenergics[ویرایش]. R03AK Adrenergics in combination with corticosteroids or other drugs, excl. آنتی ... ۱.۴ R03AH Combinations of adrenergics. *۱.۵ R03AK Adrenergics in combination with corticosteroids or other drugs, excl. آنتی ... R03DA55 Aminophylline, combinations. R03DA57 Theobromine, combinations. R03DA74 Theophylline, combinations with psycholeptics. ... R03DA20 Combinations of xanthines. R03DA51 Diprophylline, combinations. R03DA54 Theophylline, combinations excluding ...
Cancer cells divide rapidly, and drugs that interfere with folate metabolism are used to treat cancer. The antifolate drug ... "Sulfonamides and Sulfonamide Combinations". Merck Veterinary Manual. Kenilworth, NJ: Merck & Co., Inc. Retrieved 10 October ... Gonen N, Assaraf YG (August 2012). "Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance". Drug ... A number of drugs interfere with the biosynthesis of THF from folic acid. Among them are the antifolate dihydrofolate reductase ...
"Combination Products". Office of Combination Products. U.S. Food and Drug Administration. 101st U.S. Congress (August 2, 1989 ... U.S. Food and Drug Administration. March 12, 2000. Retrieved March 23, 2013. CS1 maint: discouraged parameter (link) "Premarket ... U.S. Food and Drug Administration. September 3, 2010. Retrieved March 20, 2013. CS1 maint: discouraged parameter (link) Samuel ... or drug product. The Act of Congress transferred the electronic product radiation control provisions established by the ...
Common adverse drug reactions (ADRs) associated with the use of dicloxacillin include: diarrhoea, nausea, rash, urticaria, pain ... Moellering RC (August 1983). "Rationale for use of antimicrobial combinations". The American Journal of Medicine. 75 (2A): 4-8 ... LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of ... Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 491. ISBN 9783527607495. Dicloxacillin. ...
Mismatched drug combinations, for example having an 'unprotected' period where one drug dominates can seriously increase the ... The combinations of drugs currently[when?] prescribed can be divided into two categories: non-artemesinin-based combinations ... It is now suggested that it is used in combination with other antimalarial drugs to extend its effective usage. Popular drugs ... This can involve the drug intake, combination and interactions as well as the drug's pharmacokinetic and dynamic properties. ...
This drug combination is commonly called co-amoxiclav. It is a moderate-spectrum, bacteriolytic, β-lactam antibiotic in the ... Use of the amoxicillin/clavulanic acid combination for more than one week has caused a drug-induced immunoallergic-type ... "International brand names for amoxicillin". Archived from the original on 29 May 2016. Retrieved 15 ... other drug combinations are also effective. Amoxicillin is effective for treatment of early cutaneous Lyme borreliosis; the ...
... is one of the most used drugs in pregnancy, and has been found to be generally harmless both by the Food and Drug ... It is sometimes used in combination with other antibiotics that have different mechanisms of action, like vancomycin, linezolid ... "Drug interactions between ampicillin and cholera vaccine, live". Archived from the original on 23 February 2018. ... "Drug interactions between ampicillin and typhoid vaccine, live". Archived from the original on 23 February 2018. ...
Ladiges W, Liggitt D (2017). "Testing drug combinations to slow aging". Pathobiology of Aging & Age-related Diseases. 8 (1): ... "Acarbose". Drug Information Portal. U.S. National Library of Medicine. "Probing the Pancreas" - by Craig D. Reid, Ph.D. (US FDA ... The combination of acarbose with metformin results in greater reductions of HbA1c, fasting blood glucose and post-prandial ... Drug Therapy in Nursing, 2nd Edition. Scheen AJ (September 1998). "Clinical efficacy of acarbose in diabetes mellitus: a ...
Lange, Joep (1995). "Combination Antiretroviral Therapy". Drugs. 49 (Supplement 1): 32-37. doi:10.2165/00003495-199500491-00008 ... During the mid-1990s, Lange began advocating for the use of combination therapy in the management of HIV/AIDS. He argued that ... He found that a baby's chance of contracting HIV falls to less than 1% if they receive anti-retroviral drugs while being nursed ... The institute is meant to continue the unique combination of scientific research, pragmatism and action that characterised Joep ...
... the drug may find use as initial single therapy or as an adjuvant to reduce tumor load prior to combination with HCST. Ongoing ... That is, many types of these disorders are remarkably susceptible to relatively non-toxic drugs. Hematopoietic stem cells give ... The tyrosine kinase inhibitor Ponatinib has been used as mono-therapy and subsequently used in combination with intensive ... PDGFRA fusion gene-induced diseases generally respond well to the first line treatment drug, tyrosine kinase inhibitor, ...
Many medicinal drugs can lead to pulmonary toxicity. A few medicinal drugs can lead to pulmonary toxicity frequently (in ... Any combination is also possible, of course. Pulmonary toxicity is possible due to many chemical compounds. However, the most ... The treatment of pulmonary toxicity due to medicinal drugs is to discontinue (= to stop taking) the medicinal drug in question ... These medicinal drugs can include gold and nitrofurantoin, as well as the following drugs used in chemotherapy for cancer: ...
US Food and Drug Agency. 27 March 2013. Archived (PDF) from the original on 4 October 2013. Retrieved 5 April 2013.. "NDA ... The cause of MS is unknown; however, it is believed to occur as a result of some combination of genetic and environmental ... US Food and Drug Agency. 27 March 2013. Archived (PDF) from the original on 4 October 2013. Retrieved 5 April 2013.. ... "Press Announcements - FDA approves new oral drug to treat multiple sclerosis". Retrieved 22 April 2019.. ...
Brochado, Ana (4 July 2018). "Species-specific activity of antibacterial drug combinations". Nature. 559 (7713): 259-263. ... A. H. van Assendelft, "Adverse drug reactions checklist" in the British Medical Journal, February 28th, 1987, pp. 576-577. ...
Roe, Sam; Long, Ray; Kin, Karisa (December 15, 2016). "Pharmacies miss half of dangerous drug combinations". Chicago Tribune. ... "Pharmacies miss half of dangerous drug combinations", December 1, 2016 2017: "Allegiant Air" by William R. Levesque, Nathaniel ... Roe, Sam; King, Karisa (February 11, 2016). "Big data offers new way to find hidden drug interactions". Chicago Tribune. ... "Big data offers new way to find hidden drug interactions", February 11, 2016 "Mix of medications leaves woman fighting for life ...
"Drug Approval Package: Hyrimoz". U.S. Food and Drug Administration (FDA). 21 March 2019. Retrieved 17 December 2019. "Drug ... combination therapy and monotherapy; various diseases, etc. on the purpose to verify comparability in pharmacokinetics of the ... "Drug Approval Package: Herzuma". U.S. Food and Drug Administration (FDA). 7 February 2019. Retrieved 17 December 2019. "Drug ... "Drug Approval Package: Eticovo". U.S. Food and Drug Administration (FDA). 18 June 2019. Retrieved 17 December 2019. "Drug ...
Hilton SE, Maradit H, Möller HJ (1997). "Serotonin syndrome and drug combinations: focus on MAOI and RIMA". Eur Arch Psychiatry ... An update on drug interactions". Drug Saf. 14 (4): 219-27. doi:10.2165/00002018-199614040-00002. PMID 8713690.. ... Serotonin syndrome has been reported when moclobemide has been taken in combination with other serotonin enhancing drugs; ... The combination of moclobemide with prescription or over the counter sympathomimetic drugs is not recommended due to the ...
"GSK melanoma drugs add to tally of U.S. drug approvals". Reuters. May 30, 2013. Archived from the original on September 24, ... "Combination of dabrafenib and trametinib delays development of treatment resistance in MM patients". News Medical. October 1, ... Yervoy Archived 2011-08-09 at the Wayback Machine *^ Robert C, Thomas L, Bondarenko I, et al. (June 2011). " ... The drug's brandname is Yervoy.[147][160] Surveillance methods[edit]. Advances in high resolution ultrasound scanning have ...
The drug causes a delay in the onset, and decrease in the duration of REM sleep. Following discontinuation of the drug, REM ... Alcohol in combination with nitrazepam may cause a synergistic enhancement of the hypotensive properties of both ... The drug was recommended to join the barbiturates in not being prescribed to the elderly. Only nitrazepam and lorazepam were ... It is a popular drug of abuse in countries where it is available. Doses as low as 5 mg can impair driving skills. Therefore, ...
The use of lenalidomide combined with other drugs was evaluated. It was seen that the drug combinations of lenalidomide plus ... In 2006, lenalidomide received U.S. Food and Drug Administration (FDA) clearance for use in combination with dexamethasone in ... Cochrane Haematology Group) (November 2019). "Multiple drug combinations of bortezomib, lenalidomide, and thalidomide for first ... In March 2008, the U.S. Food and Drug Administration (FDA) included lenalidomide on a list of twenty prescription drugs under ...
Furthermore, combination chemotherapy allows multiple independently-acting drugs to be administered at their maximum dose, ... VAMP regimen or VAMP chemotherapy is a four-drug combination chemotherapy regimen, used today in the treatment of Hodgkin ... Combining multiple chemotherapeutic drugs into one treatment helps overcome the problem of drug resistance. ... confirming the effectiveness of combination chemotherapy and leading to the use of combination chemotherapy regimens to treat ...
"Zeposia: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 27 March 2020. "U.S. Food and Drug ... The cause of MS is unknown; however, it is believed to occur as a result of some combination of genetic and environmental ... "FDA approves new oral drug to treat multiple sclerosis". U.S. Food and Drug Administration (Press release). Retrieved 22 April ... Many of the newest drugs as well as those under development are probably going to be evaluated as therapies for PPMS or SPMS. ...
FDA Professional Drug Information for Lenvima. "Lenvatinib in combination with Everolimus". U.S. Food and Drug Administration ( ... "Lenvatinib". Drug Information Portal. U.S. National Library of Medicine. "Lenvatinib mesylate". Drug Information Portal. U.S. ... Food and Drug Administration (FDA) approved it (in combination with everolimus) for the treatment of advanced renal cell ... The drug is also approved in the US and in the European Union for hepatocellular carcinoma that cannot be removed surgically in ...
"Clindamycin hydrochloride". Drug Information Portal. U.S. National Library of Medicine. International Drug Names Medicine ... The combination of clindamycin and quinine is the standard treatment for severe babesiosis. Clindamycin may also be used to ... American Academy of Pediatrics Committee on Drugs (September 2001). "Transfer of drugs and other chemicals into human milk". ... "Breastfeeding and maternal medication : recommendations for drugs in the Eleventh WHO Model List of Essential Drugs". World ...
Burk, Jeff (July 1988). "Eddie Hill's Four-Second Combination". Drag Racing magazine. Peterson Publishing Company. p. 83. " ... He started racing drag boats after attending a drag boat event in 1974 and he won championships in all of the major boat drag ... He quit water drag racing after he suffered broken bones at a crash in Arizona and returned to land drag racing in 1985. ... Hill decided to come back into drag racing for 1985. He purchased Dan Pastorini's Top Fuel car and salvaged the drag boat ...
"Combination Therapy and Drug Interactions". In Levy RH, Mattson RH, Meldrum BS, Perucca E (eds.). Antiepileptic drugs (5th ed ... Center for Drug Evaluation and Research. "Drug Interactions & Labeling - Drug Development and Drug Interactions: Table of ... "Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers". Park JY, Kim KA, Kim SL (November 2003 ... Flockhart DA (2007). "Drug Interactions: Cytochrome P450 Drug Interaction Table". Indiana University School of Medicine. ...
This finding was applied to humans in 1971 when Sterman trained an epileptic to control her seizures through a combination of ... 70% of sufferers saw a 50% or more reduction in their migraines following combined neurotherapy and drug treatment, as opposed ... allowing the patient to greatly reduce the drug therapy necessary for him to function successfully in school and offering a ... to 50% undergoing only traditional drug therapy.[8] Autism[edit]. The term autism encompasses a wide range of syndromes, such ...
Drug, and Cosmetic Act"(FDCA).[2] The applicant must provide scientific data from any combinations of over 100 different tests ... Under Section 408 of the Federal Food, Drug, and Cosmetic Act (FFDCA), the EPA can also regulate the amount of pesticide ... any nitrogen stabilizer, except that the term "pesticide" shall not include any article that is a "new animal drug" within the ... that has been determined by the Secretary of Health and Human Services not to be a new animal drug by a regulation establishing ...
Staff (29 January 2013) FDA approves new orphan drug Kynamro to treat inherited cholesterol disorder U.S. Food and Drug ... They are used in combination with statins.. ResearchEdit. Investigational classes of hypolipidemic agents: *CETP inhibitors ( ... They are called lipid-lowering drugs. These are drugs which lower the level of lipids and lipoproteins in blood. ... Hypolipidemic agents, cholesterol-lowering drugs or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are ...
The development of type 2 diabetes is caused by a combination of lifestyle and genetic factors.[25][28] While some of these ... Izzedine H, Launay-Vacher V, Deybach C, Bourry E, Barrou B, Deray G (November 2005). "Drug-induced diabetes mellitus". Expert ... In those with impaired glucose tolerance, diet and exercise either alone or in combination with metformin or acarbose may ... Krentz AJ, Bailey CJ (February 2005). "Oral antidiabetic agents: current role in type 2 diabetes mellitus". Drugs. 65 (3): 385- ...
It is soluble white powder administered orally in combination with other antiviral drugs. The drug prevents protease from ... It is normally used as one of the three drugs in a triple-combination therapy for the HIV virus.[1] ... After 38 weeks, 6% of the people in the three-drug group died while 11% of the people died in the two-drug group. There were ... Viral resistance to the drug leads to the drug becoming useless since the virus evolves to have cells that are able to resist ...
"Pol Pot died after ingesting a lethal dose of a combination of Valium and chloroquine".[400] In May, Pol Pot's widow and Tep ... "Pol Pot 'killed himself with drugs'". The Guardian. Retrieved 8 August 2014 ...
This condition is called "sarcopenia". The exact cause of sarcopenia is unknown, but it may be due to a combination of the ... A novel class of drugs, called SARM (selective androgen receptor modulators) are being investigated with promising results. ...
... so each individual may find the combination that best suits their build and playing style. The search for the ideal combination ... and dragged détaché (détaché traîné) where smooth bow changes leave no audible gap between each note.[2] ...
... drug occupancy at a purported site of action can be inferred indirectly by competition studies between unlabeled drug and ... Combination of PET with CT or MRIEdit. Main articles: PET-CT and PET-MRI ... Pharmacokinetics: In pre-clinical trials, it is possible to radiolabel a new drug and inject it into animals. Such scans are ... The uptake of the drug, the tissues in which it concentrates, and its eventual elimination, can be monitored far more quickly ...
"U.S. Food and Drug Administration (FDA).. *Ebola: What You Need to Know - Scientific American articles related to Ebola; note ... The combination of severe vomiting and diarrhoea often leads to severe dehydration.[29] Next, shortness of breath and chest ... "U.S. Food and Drug Administration (FDA) (Press release). 14 October 2020. Retrieved 14 October 2020.. This article incorporates ... "U.S. Food and Drug Administration (FDA) (Press release). 20 December 2019. Retrieved 22 December 2019.. ...
"Drug Trials Snapshots: Aklief". U.S. Food and Drug Administration (FDA). 11 October 2019. Archived from the original on 19 ... Combination therapy[edit]. Combination therapy-using medications of different classes together, each with a different mechanism ... Aslam I, Fleischer A, Feldman S (March 2015). "Emerging drugs for the treatment of acne". Expert Opinion on Emerging Drugs. 20 ... Aslam I, Fleischer A, Feldman S (March 2015). "Emerging drugs for the treatment of acne". Expert Opinion on Emerging Drugs ( ...
Hepatitis E infection is normally an acute infection, suggesting the drug in combination with lymphoma may have weakened the ... Rituximab Information from the US Food and Drug Administration. *U.S. National Library of Medicine: Drug Information Portal - ... In 2014 Genentech reclassified rituxan as a specialty drug, a class of drugs that are only available through specialty ... "International Drug Price Indicator Guide. Retrieved 28 November 2015.. *^ British national formulary : BNF 69 (69 ed.). British ...
The epidemic in Nepal is driven by injecting drug users, migrants, sex workers and their clients, and MSM. Results from the ... they often appear in combination. Even moderately acute and severely acute malnourished children are more likely to die from ...
Drug risks[edit]. Filgrastim is typically dosed in the 10 microgram/kg level for 4-5 days during the harvesting of stem cells. ... In allogeneic transplants a combination of cyclophosphamide with total body irradiation is conventionally employed. This ... Immunosuppressive drugs are given for a minimum of 6-months after a transplantation, or much longer if required for the ... G-CSF drugs include filgrastim (Neupogen, Neulasta), and lenograstim (Graslopin). ...
In 1998, the National Drug Policy was approved, whose purpose is to ensure safety, efficacy, and quality of drugs, as well as ... Pre-hospital emergency medical services use a combination of basic ambulances staffed by technicians and advanced units with ... In 2000, there were 14 industries authorized to produce generic drugs and about 200 registered generic drugs were being ... Brazil is among the greatest consumers markets for drugs, accounting for 3.5% share of the world market. To expand the access ...
"Synthroid (Levothyroxine Sodium) Drug Information: Uses, Side Effects, Drug Interactions and Warnings". RxList. Archived from ... Combination of levothyroxine with ketamine may cause hypertension and tachycardia;[25] and tricyclic and tetracyclic ... "International Drug Price Indicator Guide. Retrieved 8 December 2016.. *^ Hamilton, Richart (2015). Tarascon Pocket ... "Levothyroxine (Lexi-Drugs)". LexiComp. Archived from the original on 29 September 2014. Retrieved 20 April 2014.. ...
... and finding a suitable drug or drug combination that is effective for a particular patient may require trial and error. The use ... using various drugs such as SSRI or tricyclic antidepressants,[17][18] Nonsteroidal anti-inflammatory drugs (NSAIDs),[19] ... Drugs in R&D. 8 (1): 51-7. doi:10.2165/00126839-200708010-00005. PMID 17249849.. ...
It is thought that through a combination of biochemical and biophysical stimuli, the uncommitted stem cells of the embryo will ... fluid space geometry and dimension results in a profound underprediction of nano-microscale stresses imparted by fluid drag on ... Via different signalling molecules and combinations the osteochondroprogenitor will differentiate into either osteoblasts or ...
Pharmacology is the study of drugs and their actions.. *Photobiology is the study of the interactions between non-ionizing ... In recent centuries, since the advent of modern science, most medicine has become a combination of art and science (both basic ... of Essential Drugs and Medicines Policy (2002). "Traditional medicine: growing needs and potential". World Health Organization. ... Medications (Rx): what drugs the patient takes including prescribed, over-the-counter, and home remedies, as well as ...
Open skin from intravenous drug use often exacerbates the problem.[citation needed] Skin lesion Odom, Richard B.; Davidsohn, ... Antibiotics: In early stages, penicillin or metronidazole are used in combination with topical antiseptic. Improved nutrition ...
That begins when increasing rainfall drags with it an area of quickly descending air known as the rear flank downdraft (RFD). ... Popularly reported sounds include a freight train, rushing rapids or waterfall, a nearby jet engine, or combinations of these. ... and the subjects of the video remained safe due to an unlikely combination of events: the storm in question was a weak tornado ... This downdraft accelerates as it approaches the ground, and drags the supercell's rotating mesocyclone towards the ground with ...
Drug Testing and Analysis. 11 (1): 140-156. doi:10.1002/dta.2471. hdl:10072/382912. PMID 30109771.. ... and restrictions upon smoking in public places reduce general smoking rates through a combination of stigmatisation and ... Drug and Alcohol Review. 37 (7): 912-921. doi:10.1111/dar.12848. PMID 30051520.. ... "What a drag … Iceland considers prescription-only cigarettes". The Guardian. Guardian News. Retrieved 14 March 2014 ...
"Infection and Drug Resistance. 8: 119-128. doi:10.2147/IDR.S66739. PMC 4440423. PMID 26028977.. ... Diagnosis is based upon a combination of symptoms, history of tick exposure, and possibly testing for specific antibodies in ... A hexavalent (OspA) protein subunit-based vaccine candidate VLA15 was granted fast track designation by the U.S. Food and Drug ... disease-modifying antirheumatic drugs (DMARDs), or arthroscopic synovectomy.[30] Physical therapy is recommended for adults ...
... that the use of spine manipulation in clinical practice is a cost-effective treatment when used alone or in combination with ... American chiropractors found that a slight majority favored allowing them to write prescriptions for over-the-counter drugs.[37 ...
In the Grand Prix jump-off of 16 combinations, Lantinus was early to jump and took the lead, but they were eventually beaten by ... O'Connor won an individual showjumping gold medal with his horse Waterford Crystal but was later stripped of it because of drug ... "Showjumper Lynch withdraws after positive drug test". Irish Independent. 21 August 2008. Retrieved 22 August 2008.. ... In an interview with the Irish Independent Pat Hickey accused the show-jumping industry of dragging Irish sport "through the ...
The authorities also recognize that some devices are provided in combination with drugs, and regulation of these combination ... U.S. Food and Drug Administration. Retrieved 2010-10-15.. *^ "Title 21-Food and drugs: Chapter i-Food and drug administration: ... U.S. Food and Drug Administration. Retrieved 2010-10-15.. *^ a b c d e f "General and Special Controls". Medical Devices. U.S. ... United States (Food and Drug Administration)Edit. Section 201(h) of the Federal Food Drug & Cosmetic (FD&C) Act[6] defines a ...
... colliding with Schrader and dragging his car up the track. Earnhardt collided head-on into the retaining wall at a critical ... concluded that Earnhardt's death was the result of a combination of factors, which included the last-second collision with ...
Hans Winkler, Professor of Botany at the University of Hamburg, Germany, as a combination of the words gene and chromosome.. . ... Drug Discov Today. 8(24):1121-7. PubMed. *Witzany G. 2007. Natural genome editing competences of viruses. Acta Biotheoretica. [ ...
Treatment may include some combination of surgery, radiation therapy and chemotherapy.[1] Anticonvulsant medication may be ... The toxicity and many side effects of the drugs, and the uncertain outcome of chemotherapy in brain tumors puts this treatment ... Although there is no specific or singular clinical symptom or sign for any brain tumors, the presence of a combination of ... They can be treated with surgical resection, chemotherapy, radiotherapy or a combination. For some suspected low-grade (grade ...
"Men Just Weren't Made to do This: Performances of Drag at 'Walk a Mile in Her Shoes' Marches." Gender and Society, vol. 24, no ... The 1790s continued this trend, but added combinations of color. Additionally, throughout all of these decades, there was no ...
Hydrocodone Combination Products: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Hydrocodone combination products may be habit forming. Take your hydrocodone combination product exactly as directed. Do not ... Some hydrocodone combination products are used to relieve moderate-to-severe pain. Other hydrocodone combination products are ... Hydrocodone is available in combination with other ingredients, and different combination products are prescribed for different ...
Targeting leukemia with drug combinations. Cancer researchers have devised a way to rapidly screen combinations of drugs to ... Posts Tagged drug combinations. Zeroing in on drug combos against a formidable form of leukemia. Targeted cancer therapies ... Tags: AML, drug combinations, ex vivo assay, hematologic malignancies, leukemia, targeted therapy ... work by singling out gene mutations that drive tumor growth, then using a drug to block the effects of the mutant gene. But ...
Cholesterol drug combinations could cut health risk for European patients Peer-Reviewed Publication Imperial College London ... According to the authors, the findings highlight the potential for combinations of lipid lowering drugs to help close the gap ... Cholesterol drug combinations could cut health risk for European patients. Imperial College London ... risk patients achieve 2019 recommended goals and to improve this will require use of combination therapy of more than one drug ...
Thats how many of people who read a City Paper article last month are paying members. Those readers make everything free for everyone else. If you value honest, independent reporting on the real D.C., will you step up and join them in supporting local news?. ...
... a combination of four or more antibiotics can effectively kill bacteria. ... On the flip side, the researchers also found that 2,331 four-drug combinations and 5,199 five-drug combinations were less ... they also found 1,676 four-drug combinations and 6,443 five-drug combinations to be equally effective. ... We shouldnt limit ourselves to just single drugs or two-drug combinations in our medical toolbox. We expect several of these ...
Belladonna Alkaloid Combinations and Phenobarbital: learn about side effects, dosage, special precautions, and more on ... you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug ... Take belladonna alkaloid combinations and phenobarbital exactly as directed. Do not take more or less of it or take it more ... a yellow dye in some processed foods and drugs), or any drug. ... Belladonna alkaloid combinations and phenobarbital are used to ...
It covers more than 559 companies plus partners who are today developing 1365 combination therapy drugs in oncology drugs where ... Combination Therapy Analysis. * Indication Selection & Expansion Analysis. * First-in-Class Analysis. * Drug Repositioning. * ... They are designed to empower biotech/pharma professionals from a business development, drug development or investment ...
Compare miscellaneous antihypertensive combinations. View important safety information, ratings, user reviews, popularity and ... Having a combination of drugs in one pill may better control hypertension by improving compliance. Classes of antihypertensive ... Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ... provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and ...
Easy-to-read patient leaflet for Vitamin B Complex Combinations Liquid. Includes indications, proper use, special instructions ... Vitamin B Complex Combinations Liquid. Generic Name: Vitamin B Complex Combinations Liquid (VYE ta min bee KOM pleks kom bi NAY ... You must check to make sure that it is safe for you to take vitamin B complex combinations liquid with all of your drugs and ... For some drugs it does not matter. Check with your pharmacist about how to take vitamin B complex combinations liquid. ...
The Radiotherapy-Drug Combinations Consortium (RaDCom) was established by CTRad and the Cancer Research UK (CRUK) Centre for ... engage with industry on a strategic level as a key source of expertise for preclinical radiotherapy-drug combination work. ... ensure areas of need are addressed by monitoring the existing radiotherapy-drug combination preclinical and early phase ... Investigators are invited to contact RaDComs steering group to discuss proposals for preclinical radiotherapy-drug combination ...
Vertex plans to start phase 3 clinical trials of compounds called VX-659 and VX-445 as part of two different triple combination ... Vertex chooses two drugs to advance in cystic fibrosis triple combinations. Published Wed, Jan 31 20187:36 PM EST. Updated Thu ... Vertex Pharmaceuticals said its chosen two medicines to move into final stage testing in combination with two other drugs for ... said its chosen which two medicines to move into the final stage of testing in combination with two other drugs for cystic ...
In this example, to reach 50% inhibition, only 4 μM of Drug A and 2 μM of Drug B were required in combination, compared to ,41 ... Synergistic drug combinations tend to improve therapeutically relevant selectivity.. Lehár J1, Krueger AS, Avery W, Heilbut AM ... Drug combinations are a promising strategy to overcome the compensatory mechanisms and unwanted off-target effects that limit ... We highlight six combinations whose selective synergy depends on multitarget drug activity. For one anti-inflammatory example, ...
Filed Under: Drug-Device Combinations, Drug-Eluting Stents, Featured, Food & Drug Administration (FDA), Wall Street Beat ... Filed Under: 510(k), Drug Pumps, Drug-Device Combinations, Food & Drug Administration (FDA), Pharmaceuticals, Regulatory/ ... Filed Under: Drug-Device Combinations, Food & Drug Administration (FDA), Legal News Tagged With: Ocular Therapeutix ... Filed Under: Blog, Diabetes, Drug Pumps, Drug-Device Combinations, Featured, News Well, Research & Development Tagged With: ...
This combination was tried on mice models with Pseudomonas infections and the results showed that the combination was more ... 2019, July 08). Antibiotic combination effective against drug-resistant Pseudomonas. News-Medical. Retrieved on July 02, 2020 ... (accessed July 02 ... ...
A drug that cuts off the blood supply feeding tumours may boost the survival of patients with glioblastoma multiforme (GBM), a ... Publishing their findings in the Journal of Clinical Oncology, they reveal that out of 35 patients given the drug combination, ... Lead investigator Dr James Vredenburgh, a neurooncologist at Duke University, said: We found that this drug combination could ... A drug that cuts off the blood supply feeding tumours may boost the survival of patients with glioblastoma multiforme (GBM), a ...
An experimental drug from Roche helped people with an advanced form of skin cancer live longer without their disease worsening ... when used in combination with another treatment, the Swiss drugmaker said on Monday. ... Pharmaceutical companies are looking to combination therapy to yield better results and drug cocktails are expected to be ... ZURICH (Reuters) - An experimental drug from Roche helped people with an advanced form of skin cancer live longer without their ...
A new drug combination may be effective in treating men with metastatic prostate cancer. Preliminary results of this new ... A new drug combination may be effective in treating men with metastatic prostate cancer. Preliminary results of this new ... The Drug Combination Actually Tested to Treat Metastatic Prostate Cancer (IMAGE) view more ... Promising drug combination for advanced prostate cancer. University of Montreal Hospital Research Centre (CRCHUM) ...
Delivering a combination of antibiotic drugs and probiotics can eradicate two strains of drug-resistant bacteria that often ... Drug-Resistant Bacteria Zapped by Probiotic-Antibiotic Combination. October 18, 2018. 0 ... Scientists at MIT report that by delivering a combination of antibiotic drugs and probiotics, they could eradicate two strains ... When MRSA and Pseudomonas aeruginosa growing in a lab dish were exposed to the combination of encapsulated Bio-K+ and ...
The journal serves researchers from academia and industry, and will publish articles ranging from basic biology of drug and ... Articles describing drug dosage forms will be considered. ... Journal of Drug Delivery is a peer-reviewed, Open Access ... Figure 2: Combination drug delivery systems based on liposomes. (a) Combination of drugs encapsulated in the hydrophilic core ... Combination Drug Delivery Systems Based on Water-Soluble Polymer Conjugates. Polymer-drug conjugates are drug delivery systems ...
We make thousands of confident predictions, including structures for known protein-drug interactions lacking a structure (e.g. ... Author Summary Predicting drug-target interactions is a hot topic, and many efforts have been undertaken to do this, many using ... 2008) DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res 36(Database issue): D901-906. * ... Protein-drug selectivity is an important issue, since non-selective drugs can have undesired side-effects. The problem is ...
... and drug y (fay) individually. The experimentally observed fraction affected by a combination of drug x and drug y (faxy, O) ... predicted fraction affected by a combination of drug x and drug y given the experimentally observed fraction affected for drug ... combinations. Utilizing ex vivo assays for intracellular HIV-1 mRNA and virion production, we compared 2-drug combinations of ... then the combined effect of the 2 drugs is less than that predicted by the Bliss model and the drug combination displays ...
... a new resource that provides data showing how well pairs of FDA-approved cancer drugs performed in killing tumor cells from NCI ... The results from this work were convincing enough that we launched phase I clinical trials of both drug combinations at the NIH ... Based on whats known about how the individual drugs in these combinations work, its highly unlikely that many of these ... Using the NCI ALMANAC, we identified several different drug combinations that have never before been tested together in humans ...
Each rat was given at various times SGS742, Aricept à ®, a combination of the two drugs or no drugs at all, and was tested on ... New Memory Drug Works Best in Combination with Older Remedy. by Sam Savage ... improved memory to a larger degree than either drug alone, implying a potential for future combination therapy protocols. ... An experimental drug combined with an already-popular memory-enhancing compound may further delay memory loss in patients with ...
... *Download PDF Copy ... From the very first time we tested this drug combination on just a few animals, we saw a huge improvement, says Martinez- ... To test the applicability of the drug combination to humans, the team treated isolated human articular cartilage cells with ... They also will study whether the combination of drugs can prevent the development of osteoarthritis before symptoms develop. ...
Combination drug demonstrates 100 perfect effectiveness in adolescents with hepatitis C virus (HCV). The study, led by William ... Combination Drug "Cures" Hepatitis C in Children and Adolescents. No Trace of Virus Found in Blood of Patients After Treatment ... The combination drug showed that all patients were "cured," meaning that HCV was not detected in the blood 12 weeks after ... The first pediatric study of a combination drug to treat the hepatitis C virus (HCV) infection in children and adolescents ...
... pharmaceutical giant Abbott Laboratories is among 344 drug combinations that have been banned by the Indian health authorities. ... A powerful antibiotic combination that is marketed in India by U.S. ... Fixed-dose combination drugs, or FDCs, combine two or more drugs in a single pill. In India, many pharmaceutical companies have ... Besides antibiotic combinations, the list of banned drugs also included analgesic combinations containing nimesulide, and ...
... of California San Diego School of Medicine and Moores Cancer Center looked for combinations of mutated genes and drugs that ... The study, published July 21 in Molecular Cell, uncovered 172 new combinations that could form the basis for future cancer ... Home / Newsroom / Releases / Researchers ID Cancer Gene-Drug Combinations Ripe for Precision Medicine ... Researchers ID Cancer Gene-Drug Combinations Ripe for Precision Medicine Yeast, human cells and bioinformatics help develop one ...
... 08.07.2008. A combination drug taken within an hour after the start of ... The drug combines sumatriptan, a migraine-specific drug that affects the constriction of blood vessels, with naproxen sodium, a ... Two hours after the dose was given, about 50 percent of those who received the drug were free of any pain, compared to about 16 ... Half of the people were given the sumatriptan/naproxen drug within an hour after migraine pain started and while the pain was ...
As a leading expert in the manufacturing of combination products and drug-eluting combination products, we partner with ... Advantages of combination products Combination products offer several advantages when compared with drug delivery via oral, ... Combination Products Innovative drug-eluting devices combining silicone with pharmaceutical ingredients. Trelleborg Healthcare ... Combination Products. Start-to finish drug eluting product development and manufacturing in an FDA compliant facility ...
This combination is made of epigenetic inhibitors and B-cell lymphoma 2 (BCL-2) inhibitors. BCL-2 inhibitors are already ... Researchers create novel combination as potential therapy for high-risk neuroblastoma. ... approved by the U.S. Food and Drug Administration. ... New Drug Combination for High-Risk Neuroblastoma. by Chrisy ... Drug Toxicity. Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, ...
  • Cancer researchers have devised a way to rapidly screen combinations of drugs to identify pairs of agents most likely to work synergistically against some of the most difficult to treat forms of leukemia. (
  • In total, the researchers tested 18,278 combinations. (
  • The team of researchers used ceftazidime-avibactam - a combination that is being used against serious bacterial infection and fosfomycin that is used in treatment of urinary tract infections. (
  • The team of researchers used this combination of antibiotics to destroy the enzymes present in the cell walls of the bacteria. (
  • The combination led to reduced " P . Aeruginosa colony-forming units (CFUs)", the researchers added. (
  • Researchers at Duke University found that Bevacizumab (Avastin), a drug that stunts the growth of blood vessels that feed a tumour's growth and spread, may increase the amount of time that patients can survive without tumour growth if given in conjunction with a standard chemotherapy drug. (
  • In a Phase 1 clinical trial, researchers tested the safety of a preliminary combination treatment of abiraterone acetate and another drug not yet approved for market, JNJ-56021927. (
  • If shown to be successful in future tests in animals and humans, the probiotic/antibiotic combination could be incorporated into dressings for wounds, where it could help heal infected chronic wounds, the researchers say. (
  • If you ask most cancer researchers how we can achieve greater therapeutic gains for patients, they will almost certainly cite the need to find effective combinations of treatments. (
  • Now, NCI has released a new, easy-to-use resource to help researchers identify potentially promising combinations of cancer drugs. (
  • With this new resource, we've done some heavy lifting for the research community, performing a resource-intensive, robust drug screen to generate data that can provide researchers with new hypotheses to advance to the next stage of investigation. (
  • Based on these data, the NCI researchers conducted more in-depth analyses of this combination, including testing in different triple-negative breast cancer mouse models and performing molecular analyses of tumor samples from treated mice. (
  • An experimental drug combined with an already-popular memory-enhancing compound may further delay memory loss in patients with Alzheimer's disease and other dementias, Johns Hopkins University scientists, in collaboration with researchers from University of North Carolina, have found. (
  • The team compared SGS742 with Aricept à ® (generic name: donepezil), an approved and frequently used treatment for Alzheimer's disease manufactured by Eisai Inc. Ltd. The Johns Hopkins researchers found in animal studies that a combination of SGS742 and Aricept à ® improved memory to a larger degree than either drug alone, implying a potential for future combination therapy protocols. (
  • Now, Salk researchers have discovered that a powerful combination of two experimental drugs reverses the cellular and molecular signs of osteoarthritis in rats as well as in isolated human cartilage cells. (
  • The researchers also observed that two drugs which have since been withdrawn due to side-effects - sibutramine and rimonabant - were also effective at promoting weight loss. (
  • In an effort to expand the number of cancer gene mutations that can be specifically targeted with personalized therapies, researchers at University of California San Diego School of Medicine and Moores Cancer Center looked for combinations of mutated genes and drugs that together kill cancer cells. (
  • The researchers first used yeast to quickly and cheaply screen 169,000 interactions between yeast versions of human tumor-suppressor genes and genes that can be inhibited with drugs, sometimes called "druggable" targets. (
  • The researchers ended up with 172 drug-gene mutation combinations that successfully killed both yeast and human cancer cells. (
  • But 172 combinations is a lot, more than a single lab can test, the researchers say. (
  • Although the combination of lenvatinib and pembrolizumab was associated with some notable side effects, these adverse events are often adequately managed" the researchers said. (
  • Many fixed-dose drug combinations widely sold in India to treat some conditions lack the necessary central regulatory approval, say British researchers. (
  • Using information from CDSCO on FDC formulations approved between 1961 and 2013, and FDC sales data between 2007 and 2012 from PharmaTrac (a database of drug sales in India), the researchers analyzed approval status and sales volumes of FDCs in four therapeutic areas. (
  • It could also help researchers find better combinations of drugs to treat complex diseases. (
  • With this, MIT researchers propose that combining kinase inhibitors with experimental drugs called ribonucleases can result in improved medical treatments. (
  • However, following the successful reactions seen on human cells within the laboratory, the researchers have developed a ribonuclease drug. (
  • The drug targets neuroinflammation, and researchers think this could halt further neuronal loss in Parkinson's disease. (
  • Researchers were hopeful that the combination treatment could extend survival times of patients with this aggressive cancer. (
  • Furthermore, researchers from the University of Sydney have found that other anti-cancer drugs may also provide the key to treating aggressive diseases and cancers. (
  • These are no longer the only options as researchers continue to develop new drugs. (
  • The researchers, led by Lynda Chin, M.D., chair of the Department of Genomic Medicine and scientific director of the Institute for Applied Cancer Science, at MD Anderson - together with colleagues from the Dana-Farber Cancer Institute at Harvard Medical School and from Boston University - discovered that the two drugs, which inhibit Mek and Cdk4, complement one another by targeting unique cancer features. (
  • Researchers must first know what an effective treatment actually looks like before they can identify and develop effective drug combinations. (
  • The researchers speculated that comparing the molecular effects of a drug versus genetically switching off mutant NRAS would reveal what mechanism(s) the drug lacks to be effective. (
  • The researchers used Mek inhibitors as a starting point because these drugs are already in late stage clinical development in which they have been shown to slow tumor growth without shrinking them. (
  • Researchers at the University of Sheffield carried out a study to find out whether a combination of the chemotherapy drug doxorubicin and the bone-protecting drug zoledronic acid had a beneficial effect on the growth of breast tumours. (
  • Researchers from the Icahn School of Medicine at Mount Sinai achieved significant beta cell proliferation using a combination of pharmacologic and genetic inhibition. (
  • At the same time, researchers agreed that the record of the past decade-every company running negative, single-drug trials on their own-calls for change. (
  • A three-drug cocktail could be "life-changing" for patients with cystic fibrosis, researchers reported Thursday. (
  • Researchers tested two experimental Vertex drugs among patients taking another dual combination of the drugs lumacaftor and tezacaftor. (
  • The value of the third drug is that it helps correct a genetic malfunction by adding a synergistic effect to the dual combinations, the researchers said. (
  • The researchers added that the tendency of youth to skip medications demonstrates the need for more contact with clinical staff during therapy, and for the development of strategies to ensure that at-risk youth take the drug as prescribed. (
  • In an MD Anderson-led study presented at the San Antonio Breast Cancer Symposium today, researchers presented new data about a combination drug therapy for women with metastatic breast cancer. (
  • A team of researchers from Florida State University, Johns Hopkins University and the National Institutes of Health has found existing drug compounds that can both stop Zika from replicating in the body and from damaging the crucial fetal brain cells that lead to birth defects in newborns. (
  • All of the researchers are continuing the work on the compounds and hope to begin testing the drugs on animals infected with Zika in the near future. (
  • The US Food and Drug Administration (FDA) has approved the use of a two-drug combination developed by researchers at Rational Therapeutics Institute (Long Beach, Calif) for the treatment of ovarian cancer. (
  • Researchers believe that blocking that interaction sensitized ACC cancer cells to cisplatin--a drug that under normal conditions, wouldn't work. (
  • The researchers, led by Andrzej J. Jakubowiak, MD, PhD, professor of medicine and director of the multiple myeloma program at the University of Chicago Medical Center, found that combining carfilzomib, a next generation proteasome inhibitor, with two standard drugs -- lenalidomide and low-dose dexamethasone compared favorably to other frontline regimens. (
  • The study's methods draw on the researchers' previous findings that combination therapy may be effective even when bacteria become resistant to colistin, which is considered a treatment agent of last resort that can punch holes in the tough outer shell of Gram-negative bacteria. (
  • Researchers at the National Institutes of Health have discoveredthat a combination of protease inhibitors and other anti-HIV drugsused to treat people with AIDS can prevent or delay the progression ofcytomegalovirus (CMV) retinitis, a potentially blinding eyecomplication of AIDS. (
  • The Chicago Tribune, in a unique collaboration with data scientists, pharmacologists and cellular researchers at Columbia University Medical Center, set out to see if these same novel techniques could be used in the hunt for risky drug pairs. (
  • The team next turned to Columbia cellular researchers, who tested one of the drug combinations on individual cells. (
  • Typically, researchers trying to spot drug interactions analyze the FDA archive and scientific literature for signs that a pair of medications is causing harm. (
  • The researchers could use the side effects to lead them to drug pairs that might be risky. (
  • With the American Cancer Society estimating 192,000 new cases of breast cancer this year, researchers at The Cancer Institute of New Jersey (CINJ) have announced a clinical trial which will evaluate a new drug combination for breast cancer patients who are set to undergo surgery to remove the tumor. (
  • Researchers say that if successful, the drug could improve doctors' ability to reduce the size of breast cancer tumors. (
  • In a paper published in the journal JCI Insights on September 21, researchers report that a combination of toll-like receptors (TLR) agonists - specialized proteins that initiate immune response to foreign pathogens or, in this case, cancer cells - and other immunotherapies injected directly into a tumor suppresses tumor growth throughout the whole body. (
  • Targeted cancer therapies work by singling out gene mutations that drive tumor growth, then using a drug to block the effects of the mutant gene. (
  • New findings from a large European study of patients in 18 countries, including the UK, show that while many patients are able to reduce their risk through taking statins, those at the highest risk of cardiovascular events may benefit from combinations of lipid-lowering therapies. (
  • Indeed, combination therapies are viewed as a central way to overcome one of the most vexing issues in cancer therapy: treatment resistance. (
  • The study, published July 21 in Molecular Cell , uncovered 172 new combinations that could form the basis for future cancer therapies. (
  • H3K27 demethylation inhibition is a promising therapeutic target to treat high-risk neuroblastoma, and H3K27 demethylation can be part of rational combination therapies to induce anti-neuroblastoma activity ," Faber said. (
  • This finding allows us to identify and validate antihypertensive combinations, offering a generic, powerful network methodology to identify efficacious combination therapies in drug development. (
  • New BRAF inhibitor drugs are effective against BRAF-mutant melanoma, but no comparable therapies are currently available against NRAS-mutant melanoma. (
  • Combination therapies are found to show better efficacy than monotherapies. (
  • Previous smaller clinical trials of anti-clotting therapies failed to show that these drugs improve AV graft patency or that they could be used safely in dialysis patients. (
  • In November 1995, Rational Therapeutics received emergency approval from the FDA to use the platinum-plus-gemcitabine combination to treat a late-stage ovarian cancer patient who had failed all conventional therapies. (
  • Combination therapies are emerging as superior treatment options for many diseases, including oncology. (
  • To facilitate combination therapies, multiple drug pump devices may be assembled into a larger system. (
  • Meheus shows that combination therapies (the use of multiple drugs ) is a cost-effective alternative to the current first-line treatments. (
  • Currently less than 10% of very-high risk patients in Europe receive some form of combination therapy, 9% with ezetimibe and 1% with PCSK9 inhibitors. (
  • These treatments, such as ezetimibe, bempedoic acid, or PCSK9 inhibitors, can be used in combination with statins to further reduce LDL-cholesterol levels. (
  • Just 9% of patients were prescribed ezetimibe with moderate intensity statins and just 1% of patients used PCSK9 inhibitors in combination with statins and/or ezetimibe. (
  • Classes of antihypertensive combinations include ACE inhibitors with calcium channel blocking agents, ACE inhibitors with thiazides, angiotensin II inhibitors with calcium channel blockers, angiotensin II inhibitors with thiazide, antiadrenergic agents (central) with thiazide, antiadrenergic agents (peripheral) with thiazide, beta blockers with calcium channel blockers, beta blockers with thiazides and potassium sparing diuretics with thiazides. (
  • The combination is made of epigenetic inhibitors and B-cell lymphoma 2 (BCL-2) inhibitors. (
  • BCL-2 inhibitors are already approved by the U.S. Food and Drug Administration. (
  • However, standard-of-care options now include treatment with immune checkpoint inhibitors, either as a combination of two checkpoint inhibitors or a checkpoint inhibitor plus a kinase inhibitor. (
  • The drug combination uses protein kinase inhibitors. (
  • Recent studies of drug combinations , including protease inhibitors, have indicated they can reduce levels of the AIDS virus in patients' blood. (
  • Dr. Stewart et al then hypothesized that combination treatment with harmine and drugs that inhibit SMAD might be able to further increase the rate of replication found with harmine monotherapy, so they focused on transforming growth factor beta superfamily (TGFβSF) receptor inhibitors, which regulate SMADs, in this latest study. (
  • This is a pilot study to determine the safety, toxicity, virologic and immunologic effects of combination therapy with hydroxyurea, a cytostatic chemotherapeutic agent, two nucleoside reverse transcriptase inhibitors and a non-nucleoside reverse transcriptase inhibitor in children with HIV infection. (
  • Exposure was the number of preventive drugs (antiplatelet agents, statins and β blockers or ACE inhibitors) used for at least 70% of the time. (
  • Protease inhibitors are aclass of promising drugs recently introduced that, when taken withother HIV-fighting medications, have shown success in prolonging thelives of people with AIDS. (
  • They explain that even among patients who are already receiving optimal doses of statins, greater use of other, non-statin cholesterol-lowering drugs could help to further reduce cholesterol levels and potentially improve health outcomes for those most at risk. (
  • Only one in five very-high risk patients achieve 2019 recommended goals and to improve this will require use of combination therapy of more than one drug. (
  • While diet and lifestyle are important factors in reducing LDL cholesterol, many patients are at increased risk - such as those with diabetes, inherited conditions or who have previously had heart attack or stroke - and are prescribed cholesterol-lowering drugs, like statins, to reduce their cholesterol. (
  • According to the authors, the findings highlight the potential for combinations of lipid lowering drugs to help close the gap and reduce the risk for millions of patients across Europe. (
  • Vertex Pharmaceuticals said it's chosen which two medicines to move into the final stage of testing in combination with two other drugs for cystic fibrosis, a key step to extending potential treatment options to 90 percent of patients with the devastating genetic disease. (
  • The company already has two medicines for CF on the market that can treat about 30,000 of the 75,000 people with the disease worldwide based on their genetic mutations, and in July saw its stock soar on initial data on three-drug combos that could treat more patients. (
  • A drug that cuts off the blood supply feeding tumours may boost the survival of patients with glioblastoma multiforme (GBM), a deadly form of brain cancer . (
  • Publishing their findings in the Journal of Clinical Oncology, they reveal that out of 35 patients given the drug combination, almost half saw no tumour progression after six months, and nearly 80 per cent were still alive six months after being diagnosed. (
  • Cobimetinib, which is being developed in collaboration with Exelixis Inc, is designed to be used with another Roche drug called Zelboraf for patients with tumors that have a mutation in a gene known as BRAF that allows melanoma cells to grow. (
  • Results of a Phase III study involving 495 patients previously untreated for advanced melanoma found those taking both drugs lived significantly longer without their disease worsening compared to those taking Zelboraf alone. (
  • say that CAV could be a safer option for pregnant women and HIV-infected patients, and that clinical trials are the next step to test the drug combination. (
  • Therefore it is important to understand the patients' treatment goals and the need for aggressive therapy including combination therapy [ 4 ]. (
  • Yet, based on further mechanistic and animal model studies for two of these combinations, NCI investigators have launched two phase I clinical trials to test these respective drug pairs in patients with advanced cancer. (
  • By augmenting the brain's memory-making ability, drugs could be used to treat this symptom and to improve the quality of life for patients who have a disease that has a slow progression over years. (
  • That's not the same as showing how these drugs affect the knee joint in humans, but we think it's a good sign that this could potentially work for patients,' says Martinez-Redondo. (
  • If approved for use in teens, ledipasvir-sofosbuvir (a combination of two anti-viral agents marketed as Harvoni®) could dramatically improve care for patients who currently have limited treatment options. (
  • The combination drug showed that all patients were "cured," meaning that HCV was not detected in the blood 12 weeks after treatment. (
  • While combination drugs are used worldwide to improve patients' compliance, in India they have proliferated to the point where in 2014 nearly half the drugs on the market were combinations. (
  • Here's one example of how this information might be useful for doctors and patients: Irinotecan is a drug only indicated by the FDA for use in colon cancer. (
  • This study also examines how well patients follow the dosing schedules for these drugs. (
  • Newswise - BOSTON - Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute , reporting results from a phase 3 clinical trial. (
  • Another group of patients received a combination of lenvatinib and everolimus, a drug that targets a protein, mTOR. (
  • The comparison drug was sunitinib, an inhibitor that targets multiple kinases and has been the standard treatment in these patients with advanced kidney cancer, which carries a poor prognosis. (
  • These combinations have achieved improved outcomes for advanced kidney cancer patients compared with sunitinib. (
  • In addition to lenvatinib plus pembrolizumab, the clinical trial also tested the combination of lenvatinib and everolimus, which is approved for patients with advanced kidney cancer whose disease progresses following sunitinib treatment. (
  • The CLEAR trial is the last of the clinical trials that were launched to compare immunotherapy and targeted drug combinations to sunitinib, and sunitinib will not be the comparison drug in future trials because the combinations have proven superior in these advanced kidney cancer patients, said Choueiri. (
  • One might think the risk of drug interactions would be lower in the hospital, where patients are under close medical supervision, but the opposite is true: The problem is even greater for people admitted to a hospital. (
  • In 2012, the Parliamentary Standing Committee on Health & Family Welfare has tabled before Parliament a unanimous 118-page report on the state of drug regulation in India and the manner in which it severely compromises the safety of Indian patients. (
  • When we looked at how well the high-risk patients were doing on ibrutinib - even though it was a small number - we saw a great opportunity to find out if combining the two drugs would have a positive impact on these patients," Burger said. (
  • One version of such drug has already made it to phase 1 clinical trial, stabilizing the disease in about 20 percent of patients. (
  • Results from a recent Phase II clinical trial found that adding bevacizumab to the common mesothelioma treatment combination of gemcitabine and cisplatin did not improve survival times for malignant mesothelioma patients. (
  • For example, mesothelioma experts like Raffit Hassan have stated that breakthrough drugs like SS1 may be able to add months to patients' lives if correct combinations are discovered. (
  • A new study published online in Nature Medicine, led by scientists at The University of Texas MD Anderson Cancer Center, describes the discovery of a novel drug combination aimed at a subset of melanoma patients who currently have no effective therapeutic options. (
  • The lack of a drug like the BRAF inhibitor that works against NRAS means that there is still no effective treatment option for NRAS-mutant patients to fall back on," said Chin. (
  • Developing an effective combination using existing drugs or drugs already in clinical development is a path to address this unmet need for this population of melanoma patients. (
  • Eli Lilly and Co. today announced that the U.S. Food and Drug Administration (FDA) has approved its gastric cancer drug Cyramza (ramucirumab) in combination with paclitaxel (a type of chemotherapy) for the treatment of advanced or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma in patients whose cancer has progressed on or after prior fluoropyrimidine- or platinum-containing chemotherapy. (
  • In the RAINBOW study, the combination treatment of Cyramza plus paclitaxel extended median overall survival of patients 9.6 months, while the treatment of placebo plus paclitaxel extended it 7.4 months. (
  • Finally, more patients responded to the combination treatment than to the treatment with paclitaxel and the placebo. (
  • In a majority of cases, combination drugs don't make any clinical difference for patients, yet pharmaceutical companies charge a significantly higher price for them. (
  • That's when manufacturers take two generic drugs, smash them together, and slap a new brand name on the old-yet-new medication, even if the dosing changes don't make any clinical difference for patients. (
  • Combination drugs do have some benefits for some patients, as taking one medication is easier than two or more. (
  • He estimated that the drug combinations fail because of drug resistance in as many as 50 percent of patients in some populations. (
  • Unfortunately, patients may take only one drug (monotherapy) when more than one is prescribed. (
  • Toca 511 and Toca FC, the company's lead investigational combination product, is being evaluated in clinical trials in patients with recurrent high grade glioma (such as glioblastoma multiforme). (
  • Within 24 hours of taking the pill combination, patients were puffing less, their sinuses were clearer, they had more energy," one researcher said. (
  • They found that adding a third drug to an existing combination of two drugs could improve the symptoms of cystic fibrosis patients, and might even help some of them live longer. (
  • Within 24 hours of taking the pill combination, patients were puffing less. (
  • One two-drug combination won FDA approval earlier this year for patients with specific mutations. (
  • In both trials, patients around the world got either the combination with one of the two new drugs, or a placebo. (
  • The company has been working to develop drugs that address other mutations, and has been testing them in various patients groups to get approval to use the drugs to treat more people. (
  • Patients were not warned of dangerous drug interactions. (
  • Finally, the secret patients (in this case, the investigative reporters) should have been warned that the combination was risky if not downright life threatening. (
  • These health professionals get a warning on their computers every time deadly drug combinations appear in patients' records. (
  • There may not be an FDC available with the appropriate drugs and/or in the most appropriate respective strength(s) for a given patient, which can lead to some patients getting too much of an ingredient and others getting too little, as the AAO notes that FDCs "limit clinicians' ability to customize dosing regimens. (
  • Pharmaceutical compounding is the practice of preparing individualized drug products for individual patients, which can aid with polypharmacy. (
  • This is still early work so we'll need more years of research to test the drug combination - checking that it's safe for patients and finding the right dose - before it could be used routinely in the clinic. (
  • All patients will also take hydroxyurea twice a day, but some will take a low dose of the drug, while others will take a high dose. (
  • When you get news of an existing approved drug most possibly being able to stop a dangerous virus from spreading, without dangerous side-effects, the right thing to do is to prescribe it immediately to all patients and not have doubts about it-they can be saved for later. (
  • CHICAGO -- A study in which women with breast cancer were given two chemotherapy drugs simultaneously was cut short after the combination contributed to the deaths of two patients and caused life-threatening complications in an alarming number of others. (
  • This drug combination provides a modest but important new therapy to keep AV grafts in good working order so patients can get the dialysis they need," said NIDDK Director Griffin P. Rodgers, M.D. "But clearly more research is needed to extend the useful life of AV grafts. (
  • To determine the effect of the number of different drugs with adherence to medication of at least 70% on recurrent admission for myocardial infarction (MI) in patients with a history of MI. (
  • Multiple drug treatment decreases admissions for recurrent MI in patients with a history of MI. (
  • A combination of docetaxel, cisplatin, and trastuzumab has shown excellent survival outcomes for patients with human epidermal growth factor receptor 2 (HER2)-positive, locally advanced breast cancer (LABC), according to a study published in the Journal of Clinical Oncology (JCO). (
  • During a conference call with investors today, CEO Barry Quart says Ardea's chief focus is on developing RDEA 594 as an add-on or alternative for patients who do not respond adequately to existing drugs. (
  • Quart says the potential market for RDEA 594 remains quite large since 60 percent of gout patients do not fully improve on the mainstay drug allopurinol. (
  • Every patient received all three drugs and the carfilzomib dose levels were increased twice for new patients as the study progressed. (
  • Most patients responded rapidly to the combination and continued to improve. (
  • Although more evaluation is needed to find out if these combinations would be effective for patients, their activity at low concentrations in the lab is promising, suggesting that they may have clinical activity at levels that are not toxic," said Brennan-Krohn. (
  • Scientists comparing treatments for gonorrhoea have identified a drug combination that could be an effective back-up for patients not responding to current therapy. (
  • To determine the clinical efficacy of indinavir sulfate or placebo in combination with zidovudine ( AZT ) and lamivudine ( 3TC ) in AIDS patients. (
  • It is hoped that combination therapy using a number of molecularly targeted drugs may decrease the chance of patients developing resistance to any individual drug. (
  • In Canada, there are currently no drugs or drug combinations with a market authorization for the treatment of patients with relapsed and refractory multiple myeloma to both lenalidomide and bortezomib. (
  • Results of a Phase III clinical trial showed that a simple drug regimen of two anti-clotting drugs - clopidogrel and aspirin - lowered the risk of stroke by almost one-third, compared to the standard therapy of aspirin alone, when given to patients who had minor or transient stroke symptoms to prevent subsequent attacks. (
  • Overall, 8.2 percent of patients taking both drugs suffered subsequent strokes in the three months of follow-up compared to 11.7 percent of patients taking aspirin alone. (
  • AMGN ) today announced the submission of a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) to expand the Prescribing Information for KYPROLIS ® (carfilzomib) to include a once-weekly dosing option in combination with dexamethasone (Kd) for patients with relapsed or refractory multiple myeloma. (
  • The minimum inhibitory concentrations (MICs) and fractional inhibitory concentration (FIC) index was performed to assess the efficacy of the antibiotics alone and in combination. (
  • They studied commercially available CAV (a duo of ceftazidime and avibactam) and compared its effectiveness to other first-line regimens using a screening tool endorsed by the FDA (called the hollow fiber system model, which allows for a quick examination of drug efficacy based on human lung pharmacokinetics). (
  • But this study suggests that this class of drugs should be evaluated for efficacy in any tumor with a mutation that inhibits RAD17 , a tumor-suppressor gene that normally helps cells fix damaged DNA. (
  • Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an important role in treating multiple complex diseases. (
  • The efficacy and tolerability of Artesunate-Mefloquine fixed-dose combination (ASMQ FDC) was tested in children under 5 years of age with uncomplicated falciparum malaria. (
  • Nasdaq: CPXX), a biopharmaceutical company that is transforming the science of combination therapy and developing products to improve patient outcomes in cancer, announced their successful R&D efforts to apply the CombiPlex technology platform to optimize the efficacy of anticancer drug combinations incorporating molecularly targeted agents (MTAs). (
  • an agent patented by the company for its efficacy against cold viruses, and Xylometazoline - a well-known drug that targets inflamed nasal mucous membranes. (
  • The combination of p53 activation and Bcl-2 inhibition reciprocally overcomes apoptosis resistance and leads to synergistic efficacy in acute myeloid leukemia. (
  • Utilizing drug combinations, clinicians can boost efficacy of lead compounds or overcome drug resistance mechanisms. (
  • Specific combinations of these probes were synergistic in enhancing efficacy. (
  • We have observed excellent efficacy, the best reported to date, and very good tolerability, including limited peripheral neuropathy that has been problematic with other drug combinations. (
  • The combination of multiple drugs enhances clinical efficacy and may delay the development of resistance of parasites. (
  • The FDA generally requires only simple bioequivalence tests to ensure that drug dosing is consistent with the individual medicines, and, at most, a small human trial to prove similar efficacy. (
  • Laboratory experiments and computational analyses reveal over 8,000 antibiotic combinations that can treat resistant bacteria. (
  • Besides antibiotic combinations, the list of banned drugs also included analgesic combinations containing nimesulide, and codeine-based drugs. (
  • Doctors and health experts say the spread and misuse of antibiotic combinations may be contributing to antibiotic resistance in India. (
  • Kirby and Thea Brennan-Krohn, MD, a post-doctoral research fellow in Kirby's lab, used a modified inkjet printer to test the activity of 20 antibiotic combinations, 18 of which contained colistin, against the Nevada strain. (
  • Currently used combination treatments in metastatic breast cancer will be discussed with their challenges leading to the introduction of novel combination anticancer drug delivery systems that aim to overcome these challenges. (
  • Current treatments for damaged osteoarthritic joint cartilage include the use of disease-modifying drugs and ultimately joint arthroplasty as unavoidable surgical intervention due to the limited ability of articular cartilage to self-regenerate. (
  • A new combination of treatments that includes a drug used to prevent bone loss may stop breast tumour growth, British scientists have found. (
  • Dr Joanna Peak, science information officer at Cancer Research UK, said: "Establishing the most effective combinations of drug treatments and the timings in which they are given is an important area of clinical research. (
  • To explain this, he said that it is believed that drug-induced beta cell regeneration would need to be accompanied by treatments that are able to prevent the autoimmunity associated with T1D, 2 a major current goal of diabetes research. (
  • Scientists have shown that a drug combination slows cancer cell growth in a type of non small cell lung cancer when tested in the lab, offering potential for developing new treatments in the future, according to a Cancer Research UK funded study published in the British Journal of Cancer today. (
  • They immediately delved into follow-up work and teamed with NIH's Zheng, an expert on drug compounds, to find potential treatments for the disease. (
  • This difference in the mechanism of action is one reason why Ardea believes combination drug treatments make sense. (
  • Sensing potential opportunity in gout, a disease with few approved treatments, the company did some further research and learned that a metabolite of the HIV drug-a molecule shed when the HIV drug broke down in the body-was responsible. (
  • The move will increase patient access to trials of potential new cancer treatments that combine molecularly targeted experimental drugs developed and owned by AstraZeneca. (
  • The charity will also hold workshops with the ECMC Network and AZ to identify promising combinations of experimental treatments to trial. (
  • The collaboration with Cancer Research UK and the ECMCs provides a key opportunity to redefining our solutions to cancer through combination treatments. (
  • Using the NCI ALMANAC, we identified several different drug combinations that have never before been tested together in humans but that nevertheless had powerful cell-killing effects in a number of the NCI-60 cell lines. (
  • The inkjet technology dispenses uniform bacterial samples into each of the 96 wells in a standard lab testing plate to allow for rapid and consistent testing of different drug combinations. (
  • New agents and combination regimens clearly have the potential to significantly improve clinical outcomes, yet they also create new challenges including limited patient population, tolerability, and compliance issues [ 11 ]. (
  • In fact, there are countless possible treatment regimens because drugs are frequently used in combination. (
  • Find information about a chemotherapy drug or combination regimen through our A-Z list. (
  • ANN ARBOR -- An experimental drug combined with the traditional chemotherapy drug cisplatin, when used in mice, destroyed a rare form of salivary gland tumor and prevented a recurrence within 300 days, a University of Michigan study found. (
  • Research and Markets( ) has announced the addition of the 'Global Cephalosporin Drugs Market 2015-2019' report to their offering. (
  • The report, Global Cephalosporin Drugs Market 2015-2019, has been prepared based on an in-depth market analysis with inputs from industry experts. (
  • One pill or dose form contains more than one class of drug, which is indicated to treat hypertension. (
  • Do not start, stop, or change the dose of any drug without checking with your doctor. (
  • Using large scale simulations of bacterial metabolism and 94,110 multi-dose experiments relevant to diverse diseases, we provide evidence that synergistic drug combinations are generally more specific to particular cellular contexts than are single agent activities. (
  • Single agent (horizontal frames) and fixed dose ratio combination curves (diagonal frames) are extracted from both dose matrices. (
  • Fixed-dose combination drugs, or FDCs, combine two or more drugs in a single pill. (
  • Two hours after the dose was given, about 50 percent of those who received the drug were free of any pain, compared to about 16 percent of those who got the placebo. (
  • It is hypothesized that a fixed-dose 3TC/ZDV tablet given bid in combination with a protease inhibitor is clinically equivalent in its effect on plasma HIV-1 RNA level to a conventional regimen of 3TC, ZDV, and a protease inhibitor. (
  • India needs to ban the sale and manufacturing of fixed-dose drug combinations not approved by the CDSCO beginning with those which include drugs banned or unapproved internationally and, therefore, most likely to be harmful," explained Patricia McGettigan who led the study at Queen Mary University of London. (
  • The development of fixed-dose combination drugs is becoming increasingly important from a public health perspective and they are commonly used to manage some of the world's most infectious diseases. (
  • Sydney, Australia- If a single dose of one drug doesn't effectively lower blood pressure or creates intolerable side effects, the solution might be to give less instead of more. (
  • Specifically, a report in the journal Hypertension finds that quarter-dose combinations of blood pressure-lowering medications appear to work better. (
  • Results indicate that two medications in combination, each at a quarter dose, was just as effective as one blood pressure-lowering medication at a standard dose. (
  • The study also determined that four medications in combination, each at a quarter dose, was nearly twice as effective as taking one blood pressure-lowering medication at the standard dose. (
  • In addition, they said, few low-dose combinations are currently available. (
  • Fixed-dose combinations with two or more antituberculous drugs in one capsule or tablet are available to prevent this. (
  • In the United States in 1993, however, only 15% to 18% of rifampin was sold in the form of fixed-dose combinations. (
  • To correct this deficiency, fixed-dose combinations should be widely promoted and accepted as a primary way to prevent drug-resistant tuberculosis. (
  • First, many fixed-dose combinations, especially those in developing countries, achieve inadequate blood levels of one or more of the component drugs, especially rifampin. (
  • Moulding T, Dutt AK, Reichman LB. Fixed-dose combinations of antituberculous medications to prevent drug resistance. (
  • The inhaler segment is further segmented into drug powder inhaler (DPI), metered dose inhaler (MDI), and soft mist inhaler (SMI). (
  • FDA also recommends that when a pharmacist receives a prescription for a combination product with more than 325 mg of acetaminophen per dosage unit that they contact the prescriber to discuss a product with a lower dose of acetaminophen. (
  • A combination drug or a fixed-dose combination (FDC) is a medicine that includes two or more active ingredients combined in a single dosage form. (
  • Note that when a combination drug product (whether fixed-dose or not) is a "pill" (i.e., a tablet or capsule), then it is also a kind of "polypill" or combopill. (
  • Initially, fixed-dose combination drug products were developed to target a single disease (such as with antiretroviral FDCs used against AIDS). (
  • On January 25, 2018, FDA issued draft guidance on developing fixed-dose combination drugs for treating hypertension. (
  • For combination antihypertensive drugs, the guidance recommends selecting previously approved antihypertensive drugs with reasonably distinct mechanisms of action to increase additive blood pressure effects while reducing dose-related adverse effects. (
  • 2) In a factorial study comparing A+B to A and to B, at the highest doses planned for the fixed combination, showing that each component contributes to the blood pressure effect, provided that other evidence supports dissimilar mechanisms of action and the doses in the combination are reasonably high on their dose-response curves. (
  • If you are taking these drugs together, your healthcare provider may need to adjust your dose of propranolol. (
  • During the acute and subacute phases of shoulder impingement syndrome, it is appropriate to use a short course of nonsteroidal anti-inflammatory drugs (NSAIDs) for analgesic and anti-inflammatory effects as an adjunct to the therapy program and other treatment modalities. (
  • NSAIDs are the most widely used drugs in the world, exhibiting anti-inflammatory, antipyretic, and analgesic activities. (
  • The context specificity of synergistic combinations creates many opportunities for therapeutically relevant selectivity and enables improved control of complex biological systems. (
  • Antihypertensive combinations have agents that control blood pressure. (
  • Antihypertensive combinations that do not fall into these classes are classified as miscellaneous antihypertensive combinations. (
  • The American Society of Hypertension (ASH) and the International Society of Hypertension (ISH) have jointly recommended initiating treatment with two antihypertensive drugs if a patient's untreated blood pressure is at least 20/10 mmHg above the target blood pressure. (
  • For clinical trial design, the guidance provides that a single phase 3, double-blind, randomized trial would generally be sufficient to demonstrate effectiveness of a combination of previously approved antihypertensive drugs. (
  • Antibiotic , or antimicrobial, resistance occurs when bacteria or viruses - sometimes called superbugs - genetically mutate and become immune to drugs. (
  • It is this enzyme that leads to the development of multi-drug resistance (MDR) in pseudomonas they wrote. (
  • The research also demonstrated that the drug combination can also aid in preventing tumors from developing drug resistance. (
  • If there is no resistance then usually a three drug combination of NRTIs with either a NNRTI or PI would be used. (
  • In those with increasing resistance other drugs are often included in the mix. (
  • The treatment of tuberculosis requires at least two drugs to retard the development of drug resistance. (
  • However, new therapeutic strategies are required in order to overcome innate and acquired resistance to these drugs and thus expand the array of cancers that could benefit from them. (
  • Our results show that combination of vorinostat and ABT-888 could potentially prove useful for treatment of cancer with innate resistance to PARPis due to active HRR machinery, while the combination of vorinostat and 6-TG could potentially overcome innate or acquired resistance to PARPis due to secondary or reversal BRCA mutations, to decreased PARP-1 level or to increased expression of multiple drug resistant proteins. (
  • The study also indicates that current widely used treatment of 1 gram azithromycin, used in combination with both drugs, is probably not enough to prevent resistance developing , and its use globally as part of dual combination therapy for gonorrhoea should be reviewed. (
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (
  • Subscribe to newsletters for the latest medication news, new drug approvals, alerts and updates. (
  • People who wish to lose weight may benefit from a combination of anti-obesity medication and lifestyle advice, scientists say. (
  • In the search for medication against Alzheimer's disease, scientists have focused - among other factors - on drugs that can break down Amyloid beta (A-beta). (
  • Combination drugs are typically new medications that are made by combining two or more generic drugs into one medication. (
  • A recent NBC News investigation highlighted the cost of one combination medication, Zegerid. (
  • Lewis says she can tell customers if there are generics available when the prescription calls for a more costly combination drug, and can call the doctor to break up the medication if cost is an issue. (
  • Similarly, the lack of HIV infection among participants who had sufficiently high blood levels of medication is consistent with studies in adults and suggests that the drug can be effective in this population when taken appropriately. (
  • increasing in frequency as people with AIDS live longer, with up to40% of all adults with AIDS eventually developing the disease.Standard treatment for CMV retinitis, which can cause blindness ifleft untreated, requires life-long medication with a variety ofanti-CMV drugs that can be cumbersome, costly, and toxic. (
  • The tests found that combination - ceftriaxone, a popular antibiotic, and lansoprazole, a former blockbuster heartburn medication best known by the brand name Prevacid - blocked an electrical channel crucial to the heart, providing a biological explanation for why these drugs might be interacting. (
  • It covers more than 559 companies plus partners who are today developing 1365 combination therapy drugs in oncology drugs where of are active in developmental projects in cancer across 555 different targets. (
  • For one anti-inflammatory example, we show how such selectivity is achieved through differential expression of the drugs' targets in cell types associated with therapeutic, but not toxic, effects and validate its therapeutic relevance in a rat model of asthma. (
  • The findings in laboratory animals "" both improved memory in our tests and evidence that the drug targets the biology for making memories in the brain "" places this drug on solid footing as a candidate therapeutic agent," said the study's lead author, Michela Gallagher. (
  • Next the team prioritized 21 drugs for which the yeast druggable targets were involved in the greatest number of cell-lethal interactions. (
  • Kalinina OV, Wichmann O, Apic G, Russell RB (2011) Combinations of Protein-Chemical Complex Structures Reveal New Targets for Established Drugs. (
  • The phase 3 CLEAR study results showed significant benefits from the combination comprised of lenvatinib, an oral kinase inhibitor that targets proteins involved in the formation of blood vessels supplying a tumor, and pembrolizumab, a checkpoint inhibitor given by infusion that helps the immune system attack the cancer. (
  • By quantifying the network-based relationship between drug targets and disease proteins in the human protein-protein interactome, we show the existence of six distinct classes of drug-drug-disease combinations. (
  • Relying on approved drug combinations for hypertension and cancer, we find that only one of the six classes correlates with therapeutic effects: if the targets of the drugs both hit disease module, but target separate neighborhoods. (
  • An example graph of polypharmacy side effects derived from genomic and patient population data, protein-protein interactions, drug-protein targets, and drug-drug interactions encoded by 964 different polypharmacy side effects. (
  • Vorinostat also sensitized PARPis insensitive cancer cell lines to 6-thioguanine (6-TG)-a drug that targets PARPis sensitive cells. (
  • Having a combination of drugs in one pill may better control hypertension by improving compliance. (
  • Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or has had an overdose, or if you have or have ever had depression or another mental illness. (
  • Taking certain medications with a hydrocodone combination product may increase the risk of serious or life-threatening breathing problems, sedation, or coma. (
  • If you take a hydrocodone combination product with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. (
  • Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with a hydrocodone combination product increases the risk that you will experience these serious, life-threatening side effects. (
  • Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment. (
  • Millions of people take up to five or more medications a day, but doctors have no idea what side effects might arise from adding another drug. (
  • Pharmaceutical companies are making billions of dollars a year charging higher prices for combination drugs that aren't any more effective than separate medications. (
  • Some of those medications include new twists on old, trusted medications called combination drugs. (
  • Dr. Robert Greenfield , a double board certified cardiologist and lipidologist and medical director of noninvasive cardiology and cardiac rehabilitation at MemorialCare Heart and Vascular Institute at Orange Coast Medical Center in Fountain Valley, California, says combination medications increase adherence and compliance, as there are fewer pills to take or doses to remember. (
  • That's the most criticized aspect of combination medications. (
  • Joanna Lewis , a pharmacist based in Jacksonville, Florida, says one such example is common blood pressure medications that are formulated into a branded combination drug. (
  • Data presented at a medical meeting in Philadelphia today showed the Ardea drug was no better at controlling gout than existing medications, including allopurinol, a cheap generic. (
  • Our findings suggest that the combination of proteaseinhibitors and other anti-HIV medications can restore the immunesystem to a point where it can fight the CMV retinitis infection onits own," said Dr. Scott Whitcup, clinical director of NEI andfirst author of the JAMA letter. (
  • For decades, scientists have wrestled with the problem that trusted prescription medications can combine in dangerous ways, often placing Americans at risk when they take more than one drug. (
  • The drugs include several widely prescribed medications, none of them linked to the cardiac condition on its own. (
  • Here we propose a network-based methodology to identify clinically efficacious drug combinations for specific diseases. (
  • Dr. Nagourney added, 'Clinically validated drug testing assays hold much promise as a means to guide drugs through the phase I-phase II transition, which is an especially costly and time-consuming part of the drug development process. (
  • Interestingly, contrary to other bacterial systems, Tmp did not show synergy in drug combinations with the three sulfa drugs at their clinically relevant serum concentrations against B. burgdorferi. (
  • While taking hydrocodone combination products, discuss with your healthcare provider your pain treatment goals, length of treatment, and other ways to manage your pain. (
  • New research has revealed that, contrary to traditional beliefs in the medical community, four- or five-drug combinations can be effective in treating infection with treatment-resistant bacteria. (
  • ZURICH (Reuters) - An experimental drug from Roche helped people with an advanced form of skin cancer live longer without their disease worsening when used in combination with another treatment, the Swiss drugmaker said on Monday. (
  • Roche is also investigating cobimetinib in combination with other experimental medicines, including an immunotherapy for the treatment of non-small cell lung cancer and colorectal cancer. (
  • The combined drugs are well tolerated and the treatment appears effective," said Dr. Saad. (
  • They hope this first combination treatment will successfully delay progression of the disease and prolong life. (
  • A brief summary of drug-resistant tuberculosis and new insight into treatment. (
  • Pairing the antibiotic ceftazidime with the enzyme inhibitor avibactam may be an effective treatment for drug-resistant tuberculosis, a new study reports. (
  • While newer antibiotics like bedaquiline and delamanid have improved patient outcomes, they are still associated with a 24-month treatment failure rate of 38% in those with extensively drug-resistant Mtb. (
  • Although in theory a combination drug therapy has advantages over single-agent therapy, no appreciable survival enhancement is generally reported whereas increased toxicity is frequently seen in combination treatment especially in chemotherapy. (
  • Among those were genes involved in inflammation and immune responses, suggesting some pathways by which the combination treatment works. (
  • In its investigation, Reuters interviewed former and current medical representatives for Abbott who said Zimnic AZ had been promoted and administered as a treatment for a broad array of illnesses, including colds, fevers, urinary tract infections, drug-resistant typhoid and sexually transmitted diseases. (
  • A new drug-combination for the treatment of high-risk neuroblastoma has been identified. (
  • A new drug-combination for the treatment of high-risk neuroblastoma using an already approved drug has been identified along with a new target for therapy. (
  • Pro-differentiation drugs have long been used as part of treatment for high-risk neuroblastoma. (
  • An intralumen medical device comprising anti-proliferative and anti-thrombotic or anti-coagulant drugs, agents or compounds may be utilized in the treatment of vascular disease. (
  • With diagnostic testing and treatment moving from the hospital laboratory to the physician's office, ambulance, or even the home, the number of combination products coming to market is on the rise. (
  • These have been reported as the most effective class of drugs in the treatment of melanoma. (
  • Because of the facial disfigurement that leprosy causes, a treatment that works faster than the standard drug combinations do would be welcome, Gelber says. (
  • To move forward, "we need to develop a means to target the combination treatment specifically to pancreatic beta cells, so as to exert maximal benefit without risking stimulating the proliferation of other, non-beta cells. (
  • These products lead to safer, effective management, and treatment of several disorders, owing to precise drug delivery, local administration, and individualized treatment. (
  • One of the drugs is already on the market as a treatment for tapeworm. (
  • To calculate the market size, the report considers revenue generated from the sales of various prescription drugs along with the generic drugs used for the treatment of various infectious diseases caused by the different strains of bacteria. (
  • The DAC trial found that the combination treatment decreased the rate of loss of primary unassisted graft patency - the useful life of a graft before it becomes blocked the first time - by 18 percent and the rate of developing significant stenosis by 28 percent, compared to placebo. (
  • This new approval covers the use of gemcitabine (Gemzar) in combination with carboplatin to treat women who've suffered an ovarian cancer relapse at least 6 months after initial treatment. (
  • Professor Jonathan Ross, chief investigator of the Birmingham trial, said: "Our current antibiotic treatment for gonorrhoea is beginning to fail and experience with previous drugs strongly suggests that this could become a widespread problem. (
  • New research led by scientists at the University of California, Los Angeles (UCLA) reveals that combining four or five antibiotics can prove surprisingly effective in killing off or slowing down the progression of drug-resistant bacteria. (
  • They expected some of these combinations to perform well against bacteria - but surprisingly, they also found 1,676 four-drug combinations and 6,443 five-drug combinations to be equally effective. (
  • I was blown away by how many effective combinations there are as we increased the number of drugs," says Prof. Savage. (
  • This combination was tried on mice models with Pseudomonas infections and the results showed that the combination was more effective in killing the bacteria compared to either antibiotic alone. (
  • A new drug combination may be effective in treating men with metastatic prostate cancer. (
  • The idea behind the NCI ALMANAC is simple: use the NCI-60 to determine whether specific drugs are more effective when used together in combination than when used alone. (
  • Analysis revealed that the combination of drugs and lifestyle guidance was effective, both at reducing weight and lowering BMI. (
  • A combination drug taken within an hour after the start of a migraine is effective in relieving symptoms, according to research published in the July 8, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology. (
  • The new study suggests that combining venetoclax with the new epigenetic drug may be even more effective. (
  • Yet, our ability to identify and validate effective combinations is limited by a combinatorial explosion, driven by both the large number of drug pairs as well as dosage combinations. (
  • A new drug combination, which is effective against the skin cancer, could save millions of lives each year. (
  • In the model, activating mutant NRAS caused melanomas to form, while turning it off caused the melanomas to shrink - exactly what an effective drug therapy should do. (
  • to guide us toward effective drug combinations. (
  • The process requires little scrutiny from the Food and Drug Administration because the ingredients have already been shown to be safe and effective, while bringing something - technically - new to the market. (
  • The rule governing fixed-combination prescription drugs, 21 CFR § 300.50, provides that each component must make a contribution to the claimed effects, and that the dosage of each component be such that the combination is safe and effective for the intended patient population. (
  • Quantitative Systems Pharmacology (QSP) is a drug discovery approach that integrates computational and experimental methods in an iterative way to gain a comprehensive, unbiased understanding of disease processes to inform effective therapeutic strategies. (
  • It's our belief that by combining conventional chemotherapy with MI-773, a drug that kills more cancer stem cells, we can have a more effective surgery or ablation. (
  • Most drugs were effective in combinations when used in standard doses. (
  • The purpose of this study is to see if it is safe and effective to give an anti-HIV drug combination of indinavir (IDV) plus stavudine (d4T) plus lamivudine (3TC) to HIV-infected children. (
  • The combination therapy was more effective than either agent alone. (
  • The team carried out many experiments in the laboratory and designed a mathematical framework - called mathematical analysis for general interactions of components (MAGIC) - that enabled them to study multiple drug combinations and anticipate their results. (
  • And since many of the cancer-killing interactions we discovered involve already FDA-approved drugs, it may mean they could reach clinical translation rapidly. (
  • Predicting drug-target interactions is a hot topic, and many efforts have been undertaken to do this, many using large interaction networks. (
  • We make thousands of confident predictions, including structures for known protein-drug interactions lacking a structure (e.g. topoisomerase-2/radicicol) and many new interactions. (
  • Large biological networks have been used previously to suggest protein-protein interactions [1] , phosphorylation events [2] and most recently drug-protein interactions. (
  • The network contains many thousands of protein-protein and protein-chemical interactions, of which several hundred involve drugs. (
  • Although not all potential drug interactions result in a bad outcome, drug interactions contribute to an increased risk of an adverse event. (
  • On average, a person who enters the hospital is treated with 10 drugs and has about a 20% probability of having a reaction caused by drug interactions. (
  • With all of the drugs on the market today, how many drug interactions are possible? (
  • Fortunately, while there are a lot of potential drug interactions, not all of them result in adverse drug reactions. (
  • He is an expert on dangerous drug interactions. (
  • You might think that doctors would catch dangerous or deadly drug interactions before they reached the pharmacy. (
  • Since FDCs are reviewed by regulating agencies (such as the Food and Drug Administration in the United States), the active ingredients used in the FDCs are unlikely to exhibit adverse drug interactions with each other. (
  • However, FDCs may interact with other drugs that a patient is taking, so the usual medical and pharmaceutical precautions against drug-drug interactions or DDIs remain warranted. (
  • 3 of 5 Using a wall he coated with special white-board paint, Columbia University data scientist Nick Tatonetti (center) works through calculations crucial to the algorithms needed to find hidden drug interactions. (
  • They are designed to empower biotech/pharma professionals from a business development, drug development or investment perspective. (
  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( ) or by phone (1-800-332-1088). (
  • The investigation is believed to be the first time anyone has discovered a potential drug interaction by searching for signals in the Food and Drug Administration's complaint archive, then confirming the findings through patient records and cellular testing. (
  • Widely studied drug delivery systems such as liposomes, dendrimers, polymeric nanoparticles, and water-soluble polymers can concurrently carry multiple anticancer drugs in one platform. (
  • Pharmaceutical companies are looking to combination therapy to yield better results and drug cocktails are expected to be crucial as oncologists seek to block cancer on multiple fronts. (
  • We are excited to continue refining this promising combination therapy for human use. (
  • As personalized medicine moves from the present emphasis on diagnosis and prognosis to therapy, the problem of searching for optimal drug combinations uniquely suited to the genetic and molecular profile of each patient will need to be solved. (
  • We all believe combination therapy will be the way forward, but we have to be scientifically driven," said Rachel Schindler at Pfizer. (
  • The study, known as Breast Cancer Trials of Oral Everolimus (BOLER0-2 ), found that combining everolimus, with hormonal therapy drug exemestane, resulted in a two-fold increase in progression-free survival for postmenopausal women who received prior endocrine therapy. (
  • Our trial results show that we now have a drug therapy that significantly prolongs the viability of AV grafts," said Bradley S. Dixon, M.D., of the University of Iowa College of Medicine, Iowa City, and lead author of the study. (
  • We have been pursuing two strategies - combination therapy and repurposing of older antibiotics - to address the challenges posed by Gram-negative infections and, as soon as this pathogen became available for research experiments, we wanted to test whether these strategies would work against the otherwise untreatable Nevada strain. (
  • Sponsors of products that combine two or more previously marketed drugs or biologics may be able to rely on existing clinical and nonclinical safety data before proceeding with clinical trials of the proposed combination therapy, according to a new FDA guidance. (
  • The drug-device products segment, for instance, covers the submarkets for antimicrobial catheters, advanced wound care products, bone graft substitutes, antibiotic bone cement, drug eluting stents, photodynamic therapy, closed loop glucose monitor and insulin pump, steroid eluting electrodes and others. (
  • The Drug Information Handbook for Oncology is designed to meet the needs of all oncology professionals involved in prescribing, preparing and administering therapy. (
  • This new drug therapy may lead to asignificant improvement in the quality of life for people with AIDSwho have CMV retinitis. (
  • The combination therapy with TLR agonist and anti-PD-1 agent activates CD8+ T cells (red) in the tumors. (
  • In addition, Cohen suggests studying these agents with other combinations such as chemotherapy and radiation therapy. (
  • The global drug-device combination products market was valued at $81,374 million in 2017 and is projected to reach $139,193 million by 2025 at a CAGR of 6.9% from 2018 to 2025. (
  • The study provides an in-depth analysis of the global drug-device combination products market with the current trends and future estimations from 2017 to 2025 to elucidate the imminent investment pockets. (
  • Lead author of the study Krisztina M. Papp-Wallace, assistant professor of medicine at the School of Medicine and a research scientist at the Cleveland VA Medical Center explained, "By successfully combining these two drugs against this widespread form of bacteria, we hope to lay a foundation for eventually eradicating the infection. (
  • The approach combines several drugs and attacks the cancer on several fronts," said Dr. Fred Saad, researcher at the University of Montreal Hospital Research Centre (CRCHUM) and principal investigator of the study. (
  • Given these encouraging results, the U.S. Food and Drug Administration and Health Canada authorized the start of a Phase 3 clinical study. (
  • Dr. Fred Saad is principal investigator of the trial entitled "A Phase 3 Randomized, Placebo-controlled Double-blind Study of JNJ-56021927 in Combination with Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Subjects with Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC) who did not Receive any Chemotherapy. (
  • They also will study whether the combination of drugs can prevent the development of osteoarthritis before symptoms develop. (
  • The first pediatric study of a combination drug to treat the hepatitis C virus (HCV) infection in children and adolescents demonstrated 100 percent effectiveness in adolescents who completed the 12-week, phase II clinical trial. (
  • The purpose of this study is to compare the safety and effectiveness of taking lamivudine (3TC) plus zidovudine (ZDV) plus a protease inhibitor (PI) with taking the 3TC/ZDV combination tablet (Combivir) plus a PI. (
  • The results of the CLEAR study showed that those receiving the combination of lenvatinib and pembrolizumab not only had longer overall survival but also longer progression-free survival - the period before their disease worsened - and a higher response rate. (
  • In a recent study done in six European countries, investigators reviewed the medicines taken by about 1600 people and found that 46% were taking at least one pair of drugs that could interact. (
  • Our research wholly supports the need for a complete overhaul of the new Drugs Bill and we urge the government of India to make this a priority," noted professor Allyson Pollock, global health expert and study co-author. (
  • The study , conducted by professor Des Richardson of the Sydney Medical School, illustrate that drugs can control the spread and growth of cancer cells. (
  • This study was conducted to evaluate and compare two drug combinations of TIVA using propofol-ketamine and propofol-fentanyl and to study the induction, maintenance and recovery characteristics following anesthesia with these techniques. (
  • This is reflected in the findings of an in vitro study which will form the basis for developing a single drug that combats viral infections as well as freeing up blocked airways. (
  • Lead author, Dr Udai Banerji, Cancer Research UK Reader at the Institute of Cancer Research, said: "There aren't yet any drugs to treat cancers with the KRAS mutation, so our study has given us a direction to focus future research on. (
  • A National Institutes of Health network study has confirmed that a combination of two drugs taken daily to reduce the chances of HIV infection among high-risk adults also works well and appears safe in males ages 15 to 17 years. (
  • The study published in JAMA Pediatrics, was funded by NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Drug Abuse, and National Institute of Mental Health. (
  • Youth with poor kidney function and a history of bone fractures were excluded from the study because the drug combination may sometimes stress the kidneys and cause bone loss. (
  • In general, study participants tolerated the drug well, and there were no reports of effects on the kidneys or bones. (
  • The authors concluded that the lack of significant adverse health events during the study indicates that the drug is safe for males under age 18. (
  • This study will test the safety and effectiveness of hydroxyurea, an anti-cancer drug, given together with the anti-HIV drugs didanosine, stavudine and efavirenz for treating children infected with human immunodeficiency virus (HIV). (
  • Upon completing either of the above factorial studies, a sponsor would not need to study combinations of lower approved doses to satisfy the combination rule, because the drugs' independent effects at lower doses can be assumed. (
  • For the first time, a combination of aspirin and the anti-platelet drug dipyridamole has been shown to significantly reduce blockages and extend the useful life of new artery-vein access grafts used for hemodialysis, according to a study by the Dialysis Access Consortium (DAC). (
  • an early-stage study is being conducted in 54 healthy volunteers to look at the safety of the drug combination. (
  • The purpose of this study is to compare the effectiveness of various combinations of anti-HIV drugs in HIV-positive men and women. (
  • This study will also see how a combination of st. (
  • In this study, we evaluated the relative activity of three commonly used sulfa drugs, sulfamethoxazole (Smx), dapsone (Dps), sulfachlorpyridazine (Scp), and also trimethoprim (Tmp), and assessed their combinations with the commonly prescribed Lyme antibiotics for activities against B. burgdorferi stationary phase cells. (
  • The Columbia scientists cautioned that the study, published earlier this month in the journal Drug Safety, does not prove cause and effect and that the results are preliminary. (
  • In this study, the combination of immunotherapy drugs resulted in the complete elimination of cancer cells and even when re-challenged the tumors did not recur. (
  • The next step should be to study these drugs in a clinical setting for head and neck cancer using FDA-approved immunotherapy. (
  • NCI ALMANAC provides data showing how well pairs of FDA-approved cancer drugs kill tumor cells from the NCI-60 Human Tumor Cell Lines. (
  • This resource, called the NCI ALMANAC , provides data showing how well pairs of Food and Drug Administration-approved cancer drugs performed in killing tumor cells from the NCI-60 Human Tumor Cell Lines , a library of cancer cell lines maintained by NCI. (
  • The NCI ALMANAC includes data on more than 5,000 pairs of FDA-approved drugs that were tested against the NCI-60-a total of 300,000 experiments. (
  • We began by conducting follow-up experiments on a subset of drug pairs identified in the database that exhibited potent cell-killing effects. (
  • With his colleague, Dan Malone, RPh, PhD, Dr. Horn advised the Chicago Tribune which drug pairs represented either a serious problem or a potentially deadly combination. (
  • In an ideal world, no pharmacy would have dispensed any of these drug pairs, period! (
  • The team then used 380,000 electronic hospital patient files to confirm which drug pairs were indeed associated with an increased risk. (
  • Atripla is a combination pill of viread (tenofovir), FTC ( emtricitabine , emtriva) and the NNRTI sustiva (efavirenz). (
  • Truvada, a single pill containing the drugs tenofovir and emtricitabine (TDF/FTC), is currently approved for daily use in adults. (
  • The synergy score S = ln f X ln f Y Σ doses max(0, Z data ) ( Z data − Z model ) sums up the excess inhibition over the HSA model with weights to account for drug dilution factors f X , f Y , and favor synergy at high inhibition levels. (
  • And each drug in each pair was tested at different doses, producing nearly 3 million data points. (
  • Trelleborg Healthcare & Medical partners with pharmaceutical companies to design and manufacture drug-device combination products . (
  • As a leading expert in the manufacturing of drug-eluting combination products, Trelleborg Healthcare & Medical partners with the pharmaceutical and medical device industries to design and manufacture the optimum product to meet all requirements. (
  • The development of combination products leads to better management of chronic disorders, reduces the levels of pain, minimizes hospital stays, and provides better healthcare cost efficiency. (
  • The growth of the Global Drug-device Combination Products Market is driven by rise in incidence of chronic diseases such as diabetes, cancer, and respiratory problems, increase in casualties owing to accidents and trauma, rise in geriatric population, growth in home-based healthcare market, and technological advancements such as development of prefilled syringes. (
  • If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood, especially when you are starting or stopping Luvox. (
  • They tested these drugs one at a time for lethal interaction with 112 different tumor-suppressor gene mutations in human cancer cells growing in the lab. (
  • This article explains why and how medicines can interact and what a drug interaction may mean for you and your health care. (
  • The most common form of drug interaction occurs when one drug interferes with another drug's elimination from the body. (
  • This newspaper sent investigative reporters to 255 pharmacies in consultation with a renowned drug-interaction expert. (
  • The medical literature suggests that prescribers frequently override drug interaction alerts that pop up on their smart phones or computers. (
  • Such combined profiles can also include effects caused by interaction between the individual drugs that may be omitted in individual drug profiles. (
  • This drug MI-773 prevents that interaction, so p53 can induce cell death," Nör said. (
  • These combinations were tested for their antitumor activity in several mouse models of human tumors, and additional experiments were performed to investigate the mechanisms by which these combinations kill tumor cells. (
  • Chemotherapy is the use of drugs to kill cancer cells and shrink tumors. (
  • First, they treated tumors in mice with a combination of MI-773 and cisplatin, and tumors shrank from about the size of an acorn to nearly zero. (
  • Research is still too early-stage to know how humans will respond, and the drug will work primarily in tumors where p53 is normal. (
  • Pazopanib, which is not yet approved by the U.S. Food and Drug Administration, has potential to block new blood vessel growth in cancer tumors, as well as targeting and halting certain proteins that help cancer cells grow. (
  • The nonsteroidal anti-inflammatory drugs (such as ibuprofen), anticoagulants , diuretics, and drugs to treat diabetes are on this list. (
  • it seeks to work with UK-based investigators to develop and deliver high quality preclinical projects evaluating specific radiotherapy-drug combinations, to provide the necessary evidence base for early phase clinical trials. (
  • The results from this work were convincing enough that we launched phase I clinical trials of both drug combinations at the NIH Clinical Center. (
  • Looking forward, Faber said that he and his research team will continue to collaborate with AbbVie Inc., the pharmaceutical company responsible for manufacturing venetoclax, to transition the combination of venetoclax and epigenetic drugs into clinical trials for neuroblastoma. (
  • The drug AZD2014 is experimental and still in clinical trials to treat solid tumours (all cancer types except leukaemia, lymphoma or myeloma). (
  • CANCER RESEARCH UK's drug development office (DDO) has signed a Strategic Combinations Alliance with AstraZeneca to take combinations of experimental cancer drugs into early phase clinical trials. (
  • Cancer Research UK and the ECMC Network have established clear processes to run early phase combination clinical trials through the ECMC Network. (
  • Drugs may be taken by pill, or administered via injection. (
  • Truvada is a combination pill of viread and FTC. (
  • This pill would contain aspirin, a cholesterol-lowering statin, the vitamin folic acid, and three blood pressure drugs - a diuretic, a beta blocker, and an ACE inhibitor. (
  • On 27 October, the California company submitted an application to the US Food and Drug Administration ( FDA ) for its four-in-one HIV pill, which, if approved, would contain more medicines than any pill currently on the US market. (
  • The so-called 'Quad' pill promises the same virus-controlling ability as the four drugs separately but should be easier to use for people with the infection. (
  • The intralumen medical device is selectively coated with the drugs, agents or compounds for local delivery, thereby increasing. (
  • The selective coating is utilized to ensure that the specific drugs, agents or compounds come into contact with or are delivered to the appropriate tissues and/or fluids for maximum effectiveness. (
  • One of the identified compounds is the basis for a drug called Nicolsamide, a U.S. Food and Drug Administration approved drug that showed no danger to pregnant women in animal studies. (
  • With our platform, you can profile your compounds as single agents or combinations across hundreds of well-annotated cancer cell lines, and gain actionable insights in a short period of time. (
  • 1-2 customer compounds in combination with a 100-200 oncocentric compound library. (
  • The report from our NCI group in Cancer Research provides an ideal case report of what the NCI ALMANAC results might mean for advancing new drug combinations into human trials. (
  • That meeting focused in particular on running Phase 2 trials on a continuous, adaptive platform that could test both combinations and single drugs against a shared control group. (
  • The U.S. Food and Drug Administration, which dispatched 10 representatives to the D.C. meeting, demonstrated strong support for combination trials, along with a willingness to be flexible on requirements. (
  • If a drug performs well, it returns to the company, which can then run proprietary confirmatory Phase 3 trials. (
  • In the two trials of the two experimental Vertex drugs, lung function improved by between 11 percent and 13 percent, the two teams reported. (
  • The trials will be managed and run through the Cancer Research UK/ UK Health Departments Experimental Cancer Medicine Centre (ECMC) Network* at hospitals across the UK with support from Cancer Research UK's Drug Development Office. (
  • Dr Sally Burtles, director of the Experimental Cancer Medicine Network, said: "It is incredibly exciting to have the opportunity to run trials of these promising new drugs which could potentially be used to treat a range of different cancers. (
  • Nano-scale delivery systems coordinate the pharmacokinetics (PK) of drug combinations after administration so that the optimal ratio of the two drugs is exposed to tumor cells for prolonged times while reducing drug exposure and toxicity to normal tissues. (
  • The findings go against the prevalent view that such drug combinations are ineffective, or that mixing different antibiotics leads to the drugs' benefits canceling each other out. (
  • Yeh comments on the findings, saying, "There is a tradition of using just one drug, maybe two. (
  • Lead author Dr Laura Gray, whose findings are published in the journal Obesity Review, said: 'This is the first review to combine all available evidence for anti-obesity drugs in a single analysis. (
  • As potential Alzheimer's disease drugs continue to post disappointing Phase 2 and 3 results, many in the field are considering upping the artillery by testing experimental drugs in combination. (
  • The drug is the cornerstone of pre-exposure prophylaxis ( PrEP ), a strategy in which healthy people at risk for HIV infection take one or more anti-HIV drugs to reduce this risk. (
  • Some studies have found that hydroxyurea may help certain anti-HIV drugs to work better and that the virus does not become resistant to it, as it does other drugs. (
  • others will not start hydroxyurea until after they have taken the anti-HIV drugs for 5 weeks. (
  • Previous research had pinpointed two molecules, alpha-KLOTHO and TGF beta receptor 2 (TGFβR2), as potential drugs to treat osteoarthritis. (
  • There are no drugs that are currently approved to treat MYCN-amplified disease, which represents about one-fourth of all neuroblastomas and has a survival rate below 50 percent. (
  • It is estimated that people over 65 take an average of seven drugs at any one time to treat a variety of illnesses. (
  • The double-blind, randomized, placebo-controlled test was designed to determine whether bevacizumab could increase the effectiveness of gemcitabine and cisplatin, two chemotherapy drugs that have been used to treat mesothelioma for years. (
  • This category of prescription drugs combines acetaminophen with another ingredient intended to treat pain (most often an opioid), and these products are commonly prescribed to consumers for pain, such as pain from acute injuries, post-operative pain, or pain following dental procedures. (
  • Trametinib has been licensed for use in the UK in combination with dabrafenib to treat metastatic melanoma in adults with a BRAF mutation. (
  • She is understood to have taken Xanax, a drug used to treat anxiety and panic disorders. (
  • The two drugs are frequently used alone to treat breast cancer. (
  • FDA approval of the carboplatin-plus-gemcitabine combination affirms the utility of ex vivo drug induced cell death analysis as a tool to guide drug development for other difficult-to-treat cancers. (
  • orphan drug one that has limited commercial appeal because of the rarity of the condition it is used to treat. (
  • In combination with other anti-malarials, they have been used effectively for several years to treat multiple-drug -resistant malaria. (
  • While lifestyle advice alone was associated with weight loss at six and 12 months, the results were less impressive than those achieved with anti-obesity drugs. (
  • The FDA based its latest approval of the drug on results from a Phase III trial referred to as RAINBOW, which compared Cyramza plus paclitaxel to placebo plus paclitaxel. (
  • Dr. Nagourney used the results of the EVA analysis to identify the combination for this patient, resulting in a remission that lasted several years. (
  • If results are good, Ardea will test the drug combination in people with gout. (
  • Two years later, the results are in: The team has identified four drug combinations associated with a heart condition that can lead to a potentially fatal arrhythmia. (
  • The present work assesses, in vitro, the effect of combining the antiretroviral drug nelfinavir (NFV - a drug used against HIV but also a strong in vitro inhibitor of the growth of Leishmania promasti. (
  • Future studies are needed to evaluate and optimize the sulfa drug combinations in vitro and also in animal models. (
  • But some drugs are not supposed to be taken simultaneously, and doctors and pharmacists don't always notice when a person is taking dangerous or risky drug combinations. (
  • To find the potentially risky combinations, the Tribune enlisted the help of scientists at Columbia, who used sophisticated algorithms to analyze a massive government database of drug complaints for signs of the heart condition. (
  • The team found that when they used the ceftazidime-avibactam-fosfomycin combination, the progression of the bacteria multiplication was significantly halted. (
  • Scientists at MIT report that by delivering a combination of antibiotic drugs and probiotics, they could eradicate two strains of drug-resistant bacteria that often infect wounds. (
  • When MRSA and Pseudomonas aeruginosa growing in a lab dish were exposed to the combination of encapsulated Bio-K+ and tobramycin, all of the pathogenic bacteria were wiped out. (
  • Because bacteria - especially Gram-negative strains - are becoming increasingly resistant to current antibiotics, investigators are studying the potential of combining two or more drugs to work together to combat resistant bacterial pathogens. (
  • The Radiotherapy-Drug Combinations Consortium (RaDCom) was established by CTRad and the Cancer Research UK (CRUK) Centre for Drug Development (CDD) in 2013. (
  • In addition, emerging bioprinting technologies in combination with implemented manufacturing techniques such electrospinning or cryogelation processes have permitted the development of new tissue substitutes with precise control of sizes and shapes to recreate the complex physiological, biomechanical and hierarchical microstructure of osteochondral interphases. (
  • C-Path is an applied research organization that facilitates precompetitive drug development. (
  • Formulation scientists experience challenges in the development stages of multi-drug formulations such as compatibility issues among active ingredients and excipients affecting solubility and dissolution If one drug is contraindicated for a patient, whole FDC cannot be prescribed(Kennedy Seele,2020) Collier, Roger (2012). (
  • The guidance concerns development of combinations of two or more previously approved drugs, but does not address combinations that include unapproved drugs. (
  • Metabolic plasticity in cancer has been linked to the development of drug-tolerant populations. (
  • The pressure has never been greater for life science organizations to shorten the development cycle for new drugs and devices. (
  • Cancer Research UK's Drug Development Office is adding value by mediating between the cross company partners and across the ECMCs. (
  • The rate of responses and complete responses, and the progression-free survival were the longest we have seen to date in a phase 3 combination of a targeted VEGF inhibitor and an immune checkpoint inhibitor," said Choueiri. (
  • So in addition to insulin or diabetes pills, other drugs are often needed to control these problems - statins for high cholesterol , diuretics or beta-blockers for high blood pressure, antidepressants for depression or neuropathy pain, and a daily aspirin to prevent a heart attack. (
  • We expect several of these combinations, or more, will work much better than existing antibiotics. (
  • Using these tools, Tekin and colleagues examined how every possible combination of four and five antibiotics affected a strain of Escherichia coli . (
  • They found that there were mutations that caused it to be resistant to beta lactam antibiotics like penicillins and cephalosporin group of drugs. (
  • A Reuters investigation revealed in December that a unit of Abbott in India was selling a combination of the antibiotics cefixime and azithromycin without approval from the central government. (
  • Investigators at Beth Israel Deaconess Medical Center (BIDMC) have now demonstrated that existing antibiotics, some of which have been in use for decades, may have potent activity against such strains when used in combination. (
  • We found that sulfa drugs combined with other antibiotics were more active than their respective single drugs and that four-drug combinations were more active than three-drug combinations. (
  • tell your doctor and pharmacist if you are allergic to belladonna, any barbiturate medicine, tartrazine (a yellow dye in some processed foods and drugs), or any drug. (
  • Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins ) and health problems. (
  • The next steps will be to test these combinations in more human cancer cell types and eventually in mouse models. (
  • WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. (
  • Is Your Pharmacist Dispensing Deadly Drug Combinations? (
  • Deadly drug combinations should never be dispensed. (
  • What they discovered is shocking: over half of the pharmacies visited dispensed dangerous or even deadly drug combinations. (
  • The experiment began with thousands of patient files, millions of prescription orders, billions of clinical measurements and a single question: Could big data be used to discover deadly drug combinations? (
  • In this model, different companies provide investigational drugs after internal Phase 1 testing. (
  • Investigational drug pazopanib to be evaluated before and after surgery. (
  • The trial will look at the effects of the investigational drug, pazopanib, when given with chemotherapy before surgery and when given without chemotherapy after surgery. (
  • Drug combinations are a promising strategy to overcome the compensatory mechanisms and unwanted off-target effects that limit the utility of many potential drugs. (
  • The rise in spending for medicine, according to the Centers for Medicare and Medicaid Services, is being partially driven by the increase of new drugs being introduced to the market. (
  • Other companies are talking privately to regulators as well as to AD consortia and research centers about testing combinations. (