Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)Leprostatic Agents: Substances that suppress Mycobacterium leprae, ameliorate the clinical manifestations of leprosy, and/or reduce the incidence and severity of leprous reactions.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Dapsone: A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)Leprosy, Multibacillary: A form of LEPROSY classified by the World Health Organization for the purpose of treatment, based on clinical manifestations and skin smear results. Patients with multibacillary leprosy have six or more lesions with or without positive skin smear results for the causative agent MYCOBACTERIUM LEPRAE. Multibacillary leprosy encompasses borderline lepromatous, midborderline, and lepromatous leprosy.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)Mycobacterium avium-intracellulare Infection: A nontuberculous infection when occurring in humans. It is characterized by pulmonary disease, lymphadenitis in children, and systemic disease in AIDS patients. Mycobacterium avium-intracellulare infection of birds and swine results in tuberculosis.Mycobacterium avium Complex: A complex that includes several strains of M. avium. M. intracellulare is not easily distinguished from M. avium and therefore is included in the complex. These organisms are most frequently found in pulmonary secretions from persons with a tuberculous-like mycobacteriosis. Strains of this complex have also been associated with childhood lymphadenitis and AIDS; M. avium alone causes tuberculosis in a variety of birds and other animals, including pigs.Drug Synergism: The action of a drug in promoting or enhancing the effectiveness of another drug.Leprosy: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.PhenazinesRifabutin: A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.Antitubercular Agents: Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.Pigmentation DisordersRoxithromycin: Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections.Erythema Nodosum: An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.Liquid Crystals: Materials in intermediate state between solid and liquid.Leprosy, Lepromatous: A chronic communicable infection which is a principal or polar form of LEPROSY. This disorder is caused by MYCOBACTERIUM LEPRAE and produces diffuse granulomatous skin lesions in the form of nodules, macules, or papules. The peripheral nerves are involved symmetrically and neural sequelae occur in the advanced stage.Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.Mycobacterium avium: A bacterium causing tuberculosis in domestic fowl and other birds. In pigs, it may cause localized and sometimes disseminated disease. The organism occurs occasionally in sheep and cattle. It should be distinguished from the M. avium complex, which infects primarily humans.Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.Arabinonucleosides: Nucleosides containing arabinose as their sugar moiety.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Viral Load: The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Anti-HIV Agents: Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.Nucleosides: Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Isospora: A genus of protozoan parasites found in the intestines of birds, amphibians, reptiles, and mammals, including man. The oocysts produce two sporocysts, each with four sporozoites. Many species are parasitic in wild and domestic animals.Encephalitozoon: A genus of FUNGI originally considered a member of the class SPOROZOEA but now recognized as part of the class MICROSPOREA.Cryptosporidium parvum: A species of parasitic protozoa that infects humans and most domestic mammals. Its oocysts measure five microns in diameter. These organisms exhibit alternating cycles of sexual and asexual reproduction.Isosporiasis: Infection with parasitic protozoa of the genus ISOSPORA, producing intestinal disease. It is caused by ingestion of oocysts and can produce tissue cysts.Encephalitozoonosis: Infection with FUNGI of the genus ENCEPHALITOZOON. Lesions commonly occur in the BRAIN and KIDNEY tubules. Other sites of infection in MAMMALS are the LIVER; ADRENAL GLANDS; OPTIC NERVES; RETINA; and MYOCARDIUM.Encephalitozoon cuniculi: A species of parasitic FUNGI. This intracellular parasite is found in the BRAIN; HEART; and KIDNEYS of several MAMMALS. Transmission is probably by ingestion of the spores (SPORES, FUNGAL).Cat-Scratch Disease: A self-limiting bacterial infection of the regional lymph nodes caused by AFIPIA felis, a gram-negative bacterium recently identified by the Centers for Disease Control and Prevention and by BARTONELLA HENSELAE. It usually arises one or more weeks following a feline scratch, with raised inflammatory nodules at the site of the scratch being the primary symptom.Branchioma: A tumor derived from branchial epithelium or branchial rests. (Dorland, 27th ed)Lymphadenitis: Inflammation of the lymph nodes.Mycobacterium Infections, Nontuberculous: Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae.Mycobacterium Infections: Infections with bacteria of the genus MYCOBACTERIUM.Bartonella henselae: A species of gram-negative bacteria that is the etiologic agent of bacillary angiomatosis (ANGIOMATOSIS, BACILLARY). This organism can also be a cause of CAT-SCRATCH DISEASE in immunocompetent patients.Immunocompetence: The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.Diarylquinolines: A class of quinoline compounds defined by the presence of two aromatic ring structures which are attached via a side chain to carbon 3 of the qunolinyl structure. The two aromatic moieties are typically NAPTHALENE and BENZENE. Several compounds in this class are used as ANTITUBERCULAR AGENTS.Tuberculosis, Multidrug-Resistant: Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.Tuberculosis, Pulmonary: MYCOBACTERIUM infections of the lung.Off-Label Use: The practice of prescribing or using a drug outside the scope of the drug's official approved label as designated by a regulatory agency concerning the treatment of a particular disease or condition.NitroimidazolesExtensively Drug-Resistant Tuberculosis: Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.
Sirturo is to be used in a combination therapy for patients who have failed standard treatment and have no other options. ... imipenem co-amoxiclav clofazimine prochlorperazine metronidazole On December 28, 2012 the U.S. Food and Drug Administration ( ... How many drugs the patient is given (patients treated with five or more drugs do better) Whether an injectable drug is given or ... When counting drugs, PZA and interferon count as zero; that is to say, when adding PZA to a four-drug regimen, another drug ...
It has been used studied in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in people ... Clofazimine produces pink to brownish skin pigmentation in 75-100% of patients within a few weeks, as well as similar ... Clofazimine was originally intended as an anti-tuberculosis drug but drug proved ineffective. In 1959, a researcher named Y. T ... Official FDA Drug Label RxList Clofazimine (most information taken from FDA) U.S. National Library of Medicine: Drug ...
Prophylaxis should be continued for the patient's lifetime unless multiple drug therapy for MAC becomes necessary because of ... Many clinicians have added one or more of the following as second, third, or fourth agents: clofazimine, rifabutin, rifampin, ... Postinfection treatment involves a combination of antituberculosis antibiotics, including rifampicin, rifabutin, ciprofloxacin ... and the possibility that the addition of another drug to the medical regimen may adversely affect patients' compliance with ...
... rifampicin is always used in combination with dapsone and clofazimine to avoid causing drug resistance. Rifampicin is sometimes ... This may also be used to monitor effective absorption of the drug (if drug color is not seen in the urine, the patient may wish ... Early detection of such multi-drug or extensively drug-resistant tuberculosis is critical in improving patient outcomes by ... Atlas of Drug Reactions. New York, NY: ChurchillLivingstone, 1985. pp. 123. Stockley, Ivan H. "Anticoagulant Drug Interactions ...
... clofazimine in combination with the antibiotics clarithromycin and rifabutin induced remission for about 2 years in patients ... progesterone and the anti-lepromatous drug clofazimine). Interestingly, the Kv1.3 blocker clofazimine has been reported to be ... "Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease". Gastroenterology ... controlled clinical trial of clofazimine compared with chloroquine in patients with systemic lupus erythematosus". Arthritis ...
Another was that by virtue of being of a combination drug, it was less likely to cause drug resistance. However, because ... Hypersensitivity reactions occur in some patients. This reaction may be more frequent in patients receiving multiple-drug ... Dapsone is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. It is also used to both ... This led GlaxoSmithKline to develop Lapdap, a combination drug consisting of chlorproguanil and dapsone. Lapdap was licensed in ...
If a patient has a QTcF of > 500ms or a significant ventricular arrythmia, bedaquiline and other QT prolonging drugs should be ... Other medications for tuberculosis that can prolong the QT interval include fluoroquinolones and clofazimine. Bedaquiline ... It is a component of the experimental BPaMZ combination treatment (bedaquiline + pretomanid + moxifloxacin + pyrazinamide). The ... Two new drug therapies might cure every form of tuberculosis. Feb 2017 Archived 2017-02-20 at the Wayback Machine. Drugs.com: ...
Its main usefulness lies in the fact that it has lesser drug interactions than rifampicin; therefore HIV infected patients on ... "Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease". Gastroenterology ... In a Phase III study administering sub-therapeutic doses of rifabutin in combination therapy to patients not identified with ... Rifabutin is well tolerated in patients with HIV-related tuberculosis (TB), but new findings suggest that patients with low CD4 ...
... is a combination of the antibiotics rifabutin, clarithromycin and clofazimine. The combination is envisaged as a new treatment ... is a combination of the anti-inflammatory drug olsalazine and the anti-gout drug colchicine. Picoconda is a bowel preparation ... In 2006 the results of a Phase II study of Heliconda in around 130 patients with resistant H. pylori infection was published. ... The company was founded in 2004 to commercialise a number of drug combinations developed by Professor Thomas Borody, a Sydney- ...
1981 - World Health Organisation (WHO) recommends a new combination drug treatment for leprosy, MDT (Multi Drug Therapy). ... 1980 - Vincent Barry and his team win the 1980 UNESCO Science Prize for their discovery of anti-leprosy drug clofazimine, ... Over the next 15 years, millions of patients are successfully treated. 1950s - The Mission's work is extended into Africa. 1954 ... The organisation is led by CEO Linda Todd, and staffed by a combination of paid staff and volunteers. This regional office ...
"Cannabis-based drugs could offer new hope for inflammatory bowel disease patients" Naftali, T; Lev, LB; Yablecovitch, D; Half, ... It is also effective when used in combination with antibiotics to treat active Crohn's disease. Budesonide is released in the ... Rifabutin, clarithromycin and clofazimine are antibiotics designed to attack mycobacterium avium subsp. paratuberculosis, which ... A pilot study found that Low-dose naltrexone, a very inexpensive drug, helped patients with active Crohn's disease. In the ...
... in combination with peginterferon or direct acting anti-viral medicines To be used in combination with ribavirin To be used in ... For use in high‐risk patients In acute diarrhoea, zinc sulfate should be used as an adjunct to oral rehydration salts ... Rose, K; Anker, JNVd (2010). Guide to Paediatric Drug Development and Clinical Research. Karger Medical and Scientific ... Pyrazinamide Rifabutin Rifampicin Rifapentine Amikacinα Bedaquilineα Capreomycinα Clofazimineα Cycloserineα Delamanidα ...
Several drugs can cause oral ulceration (e.g. nicorandil), and a trial substitution to an alternative drug may highlight a ... Hematinic deficiencies (vitamin B12, folic acid and iron), occurring singly or in combination, and with or without any ... However, common autoantibodies are not detected in most patients, and the condition tends to resolve spontaneously with ... Clofazimine, Levamisole, Montelukast, Sulodexide,. ...
... of Mycobacterium leprae are discharged from the intact skin of lepromatous patients; a preliminary report". Int J Lepr Other ... phenazine (Clofazimine)#. *pyrazine (Pyrazinamide#, Morinamide). *isoxazole (Terizidone). *Bedaquiline. Combinations. * ... "Effectiveness of single dose rifampicin in preventing leprosy in close contacts of patients with newly diagnosed leprosy: ...
When used in combination with daclatasvir *^ For the treatment of hepatitis C, in combination with direct acting anti-viral ... World Health Organization (1977). The selection of essential drugs : report of a WHO expert committee [meeting held in Geneva ... Atenolol should not be used as a first-line agent in uncomplicated hypertension in patients ,60 years ... Clofazimineα. *Cycloserineα[note 25]. *Delamanidα. *Ethionamideα[note 26] ...
To assess the tolerability of the combination regimen of clarithromycin plus ethambutol with or without clofazimine in patients ... Drug Information available for: Ethambutol Ethambutol hydrochloride Clarithromycin Genetic and Rare Diseases Information Center ... Patients with active opportunistic infections other than dMAC are permitted if dosage and clinical parameters have been stable ... Patients with the following prior conditions are excluded:. History of allergy or hypersensitivity to macrolides, ethambutol, ...
ClinicalTrials.gov summary of The Safety and Effectiveness of Clarithromycin Plus Ethambutol Used With or Without Clofazimine ... in the Treatment of MAC in Patients With AIDS ... Drug Therapy, Combination Ethambutol Clofazimine Acquired ... PRIMARY: To assess the tolerability of the combination regimen of clarithromycin plus ethambutol with or without clofazimine in ... Clofazimine ClinicalTrials.gov processed this data on August 16, 2019 This information is provided by ClinicalTrials.gov. ...
The Effectiveness of Three Drug Combinations in HIV-Infected Patients Who Have Taken Zidovudine for More Than 12 Weeks. The ... Patients are randomized in a blinded fashion to receive AZT or placebo in combination with open-label d4T or ddI for up to 48 ... phosphorylation in patients receiving a combination of zidovudine (ZDV) and d4T (ACTG 290). Conf Retroviruses Opportunistic ... Patients originally assigned to the d4T + AZT arm, which was closed 10/96, will be given the option of discontinuing AZT and ...
Data suggest that clarithromycin may have substantial activity in two- or three-drug combination regimens with clofazimine, ... Patients are randomized to one of three treatment arms containing clarithromycin in combination with ethambutol, rifabutin, or ... Drug: Indinavir sulfate Drug: Ritonavir Drug: Ethambutol hydrochloride Drug: Clarithromycin Drug: Rifabutin Phase 2 ... Data suggest that clarithromycin may have substantial activity in two- or three-drug combination regimens with clofazimine, ...
For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with ... 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. ... We report the experiences of 5 patients taking bedaquiline with delamanid in combination: ... Amk, amikacin; Amx/Clv, amoxicillin/Clavulanate; Bdq, bedaquiline; c+, culture positive; Cfz, clofazimine; Clr, clarithromycin ...
Clofazimine. Bedaquiline. Diarylquinolines. Prothionamide. Kanamycin. Norgestimate, ethinyl estradiol drug combination. ... Drug: Moxifloxacin Drug: Clofazimine Drug: Ethambutol Drug: Pyrazinamide Drug: Isoniazid Drug: Prothionamide Drug: Kanamycin ... Drug: Clofazimine Clofazimine, is an antileprosy and anti-bacterial agent. Its chemical name is 3-(p-chloroanilino)-10-(p- ... Drug: Clofazimine Clofazimine, is an antileprosy and anti-bacterial agent. Its chemical name is 3-(p-chloroanilino)-10-(p- ...
For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with ... 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. ... We report the experiences of 5 patients taking bedaquiline with delamanid in combination: ... patients 1 and 3) or clofazimine (patients 2, 4, and 5). Patient exposure to bedaquiline was 155-427 days, for a total duration ...
Management: Monitor patients for signs of methemoglobinemia (e.g., hypoxia, cyanosis) when nitric oxide is used in combination ... Clofazimine: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy ... Patient Education. • Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During ... Concurrent drug therapy issues:. • Drug-drug interactions: Potentially significant interactions may exist, requiring dose or ...
Clofazimine) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related ... The patient must remain under medical surveillance.. For advice about combination drug regimens, contact the USPHS Gillis W. ... home drugs a-z list side effects drug center lamprene (clofazimine) drug ... PATIENT INFORMATION. Patients should be warned that Lamprene (clofazimine) may cause a discoloration of the skin from red to ...
... it has been replaced by a combination of drugs. This combination, referred to as multiple drug therapy, has been highly ... Patients may take the drugs for as little as 6 months or as long as 2 years. Patients who have become disfigured or who ... The third drug, clofazimine may cause severe abdominal pain and diarrhea, as well as discoloration of the skin. Red to brownish ... Patients with MB leprosy are usually treated with all three drugs, while patients with PB leprosy are only given rifampin and ...
Patients with additional risk factors for QTc prolongation may be at even higher risk. Exceptions: Chloroquine; Clofazimine; ... Management: Consider alternatives to this drug combination. If combined, monitor for QTc interval prolongation and ventricular ... Patient Education. • Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During ... Concurrent drug therapy issues:. • Drug-drug interactions: Potentially significant interactions may exist, requiring dose or ...
... for patients in a clarithromycin and clofazimine group and 46% in a triple combination group. A more effective treatment is ... Patients who received higher daily doses of drug for longer periods of time were more likely to have a positive response. ... Combinations of drugs are usually prescribed and, if successful, require that treatment be continued for life. In a recent open ... Therapy is reported to be successful in about 40-60% of patients, with problems including drug toxicity particularly in ...
... can be cured with multi-drug therapy (MDT), a combination of three antibiotics: rifampin, clofazimine and dapsone. ... It was the main institution caring for leprosy patients in the continental United States; at its peak, it housed 400 patients. ... the new sulfone drugs were trialled on volunteer patients. Sulfone therapy proved to be the most effective leprosy treatment ... So, whats unique about armadillos that make them good carriers? Likely a combination of body temperature and the fragile ...
Resistant patients, who are unresponsive to drugs, suffer from increasingly ill health and may even die. In addition to skin ... The treatment for the disease-based on a combination of the antibiotics dapsone, rifampicin, and clofazimine-is simple, free, ... These three drugs have been used in combination in multidrug therapy since the 1980s. For many years, the strategy proved ... Resistant patients, who are unresponsive to drugs, suffer from increasingly ill health and may even die. In addition to skin ...
... clofazimine, and azithromycin. Gradual improvement occurred in all patients over a 3- to 18-month period. Two patients, however ... All patients received long-term antimycobacterial therapy with double or triple drug regimens. These included various ... combinations of clarithromycin, ethambutol, rifabutin, rifampin, ... Two patients underwent MR imaging of the head and neck on a 1.5 ... These patients had only 1- to 3-weeks duration of symptoms. One of these patients developed a right hemiplegia prior to ...
Leprosy is treated with a combination of three drugs: dapsone, rifampicin and clofazimine.... more January 2019. LepVax: safety ... patients will participate in one of the two trials. Subsequently, all patients will be categorized randomly into a group ... Leprosy is treated with a combination of three drugs: dapsone, rifampicin and clofazimine. People with dapsone allergy develop ... Leprosy patients who test positive will not be given dapsone, which will reduce the number of DHS cases. ...
Alone and in Combination, For Drug-Resistant Pulmonary Tuberculosis ... Requirement or expected requirement of clofazimine, a drug that might cause QT prolongation at current treatment doses on its ... A Patients Guide to Clinical Trials. MainTitle Evaluating the Safety, Tolerability, and Pharmacokinetics of Bedaquiline and ... Combining these two drugs, together with other anti-TB drugs, may improve outcomes for people with MDR-TB or RR-TB. The purpose ...
The drugs generally used and recommended by the World Health Organization are a combination of rifampicin, clofazimine and ... Lepromatous leprosy is much more serious; patients develop symmetric skin nodules loaded with the bacteria. These patients may ... Treatment with only one antileprosy drug will always result in drug resistance. Treatment with dapsone or any other antileprosy ... Moreover, such patients appear to become a welcome mat for trillions of foreign bacteria. Current Treatment. ...
... and to help overcome the problem of resistance they moved to combinations of three drugs, usually clofazimine, rifampicin, and ... The World Health Organization has an active campaign to get free drugs to patients around the world, yet every two minutes, a ... They were given untested drugs and were not told anything about the experiments or drugs. * Males and females were kept apart ... He announced that since this same bacterium was found in all of the leprosy patients he examined, it was likely to be the cause ...
Section I presents basic concepts of epidemiology, pathophysiology, diagnosis, medical and surgical therapy, drug-resistant ... contending with such growing challenges as drug resistance, immigration, immunosuppression, and nontuberculous mycobacterial ... Clofazimine is now available for MDR-TB treatment in the United States only from the manufacturer under an individual patient ... Fluoroquinolone drugs should always be protected by being given in combination with several other active agents, particularly ...
Combination therapy for Buruli ulcer (BU) is suboptimal. Here, Liu et al. show that the candidate drug TB47 has potent ... Existing treatments are lengthy and consist of drugs developed for tuberculosis. Here, we report that a pyrazolo[1,5-a]pyridine ... dapsone and with or without clofazimine14. Many patients experience side effects, toxicity, and potential drug resistance15,16 ... That study assessed activities of a panel of drugs with drugs with different mechanisms of actions and drug combinations and ...
Finally, the combination of these drugs may have increased their effectiveness.18 ... Patients and setting: All 40 patients with BU managed by staff of Barwon Healths Geelong Hospital (a public, secondary-level ... previous experience with the drug clofazimine has shown that antibiotics may not be effective against M. ulcerans in vivo, ... There were 40 patients, all of whom lived in the city of Geelong or on the Bellarine Peninsula. Twenty-three patients were ...
Interestingly, in the 1980s, when this drug (100-300 mg/day) was administered in a combination regimen with clofazimine as a ... Dose-limiting drug toxicity occurred in 8% of the clarithromycin-assigned patients and 6% of the placebo-assigned patients, ... with clofazimine vs 38% without clofazimine; p = .012).(69) Also, a randomized trial examining a 4-drug, oral antimycobacterial ... clarithromycin-containing combination regimens suggests that clofazimine compares poorly with ethambutol as a second drug added ...
The use of this drug in combination with existing drugs could provide new hope for MDR-TB patients with very few treatment ... While the numbers are small of patients taking clofazimine in Study C209, I think the large effect might put clofazimine high ... Single Patient Investigational New Drug) program. Clofazimine is available under SPIND for treatment of other mycobacterial ... make clofazimine an obvious drug to take extra precaution when combining with other anti-TB drugs that prolong the QT interval. ...
... a combination of three drugs.. *MDT effectively kills the pathogen and cures the patient. ... MDT comprises of three drugs, dapsone, rifampicin and clofazimine. Rifampicin and clofazimine were discovered in the early ... Since 1995, WHO has been providing free MDT for all patients in the world, initially through the drug fund provided by the ... MB patients treated with MDT are cured within 12 months. *There are virtually no relapses, i.e. no recurrences of the disease ...
RifampinRifampicin and clofazimineAntibioticsPyrazinamideLeprosy patientsRifabutinLinezolidDelamanid2017VitroInfectionWorld Health OrganAntibioticAntibacterialRelapseIndicationsSusceptibilityInjectableHypersensitivityResistantInhibitorHansen'sAntimicrobial drugMacrolidesErythema nodosum leprosumEfficacyToxicityB663Clinical trials2019MinocyclineInhibitBactericidal activityTherapeuticInteractionsAntimycobacterial drugsOrganismEffluxTumourEffective
- Leprosy can be cured with multi-drug therapy (MDT), a combination of three antibiotics: rifampin, clofazimine and dapsone. (thehorrorzine.com)
- The World Health Organization (WHO) recommends a combination of rifampin and streptomycin for 2 months for treatment of BU following evaluation of this regimen in a murine model of BU 3 . (nature.com)
- TB can usually be treated with a course of four standard, or first-line, anti-TB drugs (i.e., isoniazid, rifampin and any fluoroquinolone). (wikipedia.org)
- Treatment of MDR-TB requires treatment with second-line drugs, usually four or more anti-TB drugs for a minimum of 6 months, and possibly extending for 18-24 months if rifampin resistance has been identified in the specific strain of TB with which the patient has been infected. (wikipedia.org)
- clofazimine (CLO), 50 mg, administered daily (as well as a monthly supplemental dose of 300 mg), and rifampin (RMP), 600 mg, administered monthly ( 29 ). (asm.org)
- Single-dose treatment (rifampin, oflozacin, and minocycline ) exists only for patients with a single skin lesion. (aocd.org)
- The multi-drug therapy (MDT) recommended in 1982 by the World Health Organization (WHO) as the standard treatment for leprosy is a combination of dapsone, rifampin, and clofazimine . (internationaltextbookofleprosy.org)
- This discussion begins with the anti-leprosy drugs included in the standard WHO-recommended MDT treatment of leprosy: dapsone, rifampin, and clofazimine. (internationaltextbookofleprosy.org)
- Leprosy is treated with a combination of three drugs: dapsone, rifampicin and clofazimine. (turingfoundation.org)
- The treatment for the disease-based on a combination of the antibiotics dapsone, rifampicin, and clofazimine-is simple, free, and effective, but lengthy. (fapesp.br)
- MDT comprises of three drugs, dapsone, rifampicin and clofazimine. (who.int)
- Rifampicin and clofazimine were discovered in the early 1960s. (who.int)
- The 1980s saw the discovery of multi-drug treatment for leprosy: a combination of dapsone, rifampicin and clofazimine, given over six months to a year. (scidev.net)
- In the early 1960s, rifampicin and clofazimine, the other two components of recommended multidrug therapy (MDT), were discovered. (who.int)
- MDT consists of 3 drugs: dapsone, rifampicin and clofazimine and this drug combination kills the pathogen and cures the patient. (who.int)
- All patients improved in response to surgery and long-term antimycobacterial antibiotics. (ajnr.org)
- The most efficacious drugs for treatment are the newer macrolide antibiotics, clarithromycin and azithromycin. (ucsf.edu)
- To describe the effect of antibiotics on outcomes of treatment for Buruli or Bairnsdale ulcer (BU) in patients on the Bellarine Peninsula in south-eastern Australia. (mja.com.au)
- Drug-resistant TB therapy is more arduous, involving long-term, high-order combinations of antibiotics with severe side effects ( 4 ). (sciencemag.org)
- They are a unique class of antibiotics in which each member is a combination of at least two structurally unrelated components, groups A and B streptogramins. (asmscience.org)
- Leprosy is easily treated with a combination of antibiotics for 6 months to 2 years. (dmacdigest.com)
- Although currently recommended antibiotics for Lyme disease such as doxycycline or amoxicillin cure the majority of the patients, about 10-20% of patients treated for Lyme disease may experience lingering symptoms including fatigue, pain, or joint and muscle aches. (canlyme.com)
- It's a strong and tough infection to fight because many of the antibiotics that doctors give to patients to help them fight the infection stop working. (asu.edu)
- Efflux inhibitor drugs slow down the efflux of antibiotics like BDQ. (asu.edu)
- Blocking them could open the door for shortening the course of antibiotics and for restoring their activity against drug-resistant bacterial infections. (eurekalert.org)
- A combination of medications, called antibiotics, is used to kill the bacterium that causes leprosy. (themainstreetmarket.com)
- The project aims to detect leprosy at an early stage in leprosy patients' contacts and to better monitor the progression of the disease in leprosy patients being treated. (turingfoundation.org)
- In the earlier phase of the study, blood was collected from leprosy patients and their contacts using a finger prick. (turingfoundation.org)
- This sudy by Leiden University Medical Centre and Erasmus University Rotterdam is focused on determining the long-term effect of the BCG vaccination on leprosy patients. (turingfoundation.org)
- The second aim of the study is to test the effect of the antibiotic rifampicin on preventing leprosy from developing in new leprosy patients' contacts. (turingfoundation.org)
- In 1873, Danielson's son-in-law, Dr. Gerhard Hansen, found a bacterium in nodules of leprosy patients. (drmirkin.com)
- He announced that since this same bacterium was found in all of the leprosy patients he examined, it was likely to be the cause of the disease. (drmirkin.com)
- In 1894, the State of Louisiana followed Norway's example and established an isolation hospital for leprosy patients on an old sugar plantation in Carville. (drmirkin.com)
- Leprosy patients were brought from all over the country and dropped at Carville's gates. (drmirkin.com)
- An important element in this conclusion was the discovery of "small staff-like bodies, much resembling bacteria, lying within the cells [of leprosy patients]. (faqs.org)
- Despite this setback, he continued working to improve the conditions of leprosy patients until his death in Fluro, Norway, on February 12, 1912.In 1997, there were an estimated 1.2 million cases of leprosy worldwide, with an estimated half a million new cases occurring each year. (faqs.org)
- Status of free radicals and antioxidants in leprosy patients. (semanticscholar.org)
- Close to 16 million leprosy patients have been cured with MDT over the past 20 years. (who.int)
- The drugs used in MDT are a combination of rifampicin, clofazimine and dapsone for MB leprosy patients and rifampicin and dapsone for PB leprosy patients. (dmacdigest.com)
- ENL can affect up to 30% to 40% of leprosy patients, causing severe pain and disability. (renalandurologynews.com)
- Borderline and lepromatous leprosy patients are susceptible to ENL reactions, which can occur before, during or after treatment with multidrug treatment (MDT). (renalandurologynews.com)
- We conducted a retrospective and observational subanalysis of patients from the International Bedaquiline Study Group study who were undergoing treatment with bedaquiline and delamanid. (cdc.gov)
- We consecutively enrolled patients ≥15 years of age from the International Bedaquiline Study Group study who underwent treatment during January 1, 2008-August 30, 2016, on the basis of their exposure to both bedaquiline and delamanid during the intensive and/or continuation phase of the study. (cdc.gov)
- Delamanid will be administered with food as two 50 mg tablets (100 mg) by mouth twice a day for 24 weeks, for all study arms involving the use of this drug. (nih.gov)
- Bedaquiline and delamanid are likely to form the backbone of treatment for drug-resistant TB in some combination with other potentially cardiotoxic drugs despite these risks because the need for effective therapy is so great. (ghdonline.org)
- Two of these agents, the diarylquinoline bedaquiline (BDQ) and the nitroimidazo-oxazole delamanid, have received accelerated regulatory approval by the U.S. Food and Drug Administration (FDA) ( 7 ). (asm.org)
- The clinical trials that led to approval of bedaquiline and delamanid tested these drugs by adding one of them, for a duration of 24 weeks and 6-8 months, respectively, to optimised background [ 2 , 3 ]. (ersjournals.com)
- To date, only six cases treated with the bedaquiline−delamanid combination have been reported, mostly presenting interim results [ 4 - 6 ]. (ersjournals.com)
- Otherwise, it is recommended to start the two drugs sequentially after a washout period of 6 months, when switching from bedaquiline to delamanid, and 5 days, when switching from delamanid to bedaquiline [ 7 ]. (ersjournals.com)
- A multicentre case series was established including patients who started treatment for culture-proven MDR-TB from January 1, 2013 to August 31, 2015, and were exposed to the bedaquiline−delamanid combination for ≥30 days. (ersjournals.com)
- New drugs are being evaluated in clinical trials, but only bedaquiline and delamanid have entered the market to date. (ersjournals.com)
- Use of this technology enabled rapid (requiring only 3 s) and serial real-time monitoring of M. ulcerans in samples in vitro and in the same batch of small live animals for evaluation of drug activity. (nature.com)
- Clofazimine also showed a dosage-dependent inhibition of neutrophil motility, lymphocyte transformation, mitogen-induced PBMC proliferation and complement-mediated solubilization of pre-formed immune complexes in vitro. (wikipedia.org)
- Long-term aims of this R&D project were to: 1) Screen FRDC of clofazimine (B663) and the lead derivative (B4125) with etoposide, paclitaxel and vinblastine for synergistic drug interactions in vitro. (up.ac.za)
- Considering in vitro results and with the view to advance quickly to clinical studies, the already approved clofazimine (B663) was elected as the combination partner for paclitaxel (PTX). (up.ac.za)
- The results of this study serve to highlight the great potential of in vitro optimized synergistic FRDC against drug resistant cancers. (up.ac.za)
- 6-Mercaptopurine and its pro-drug azathioprine are widely used as immunomodulators in the treatmentof CD and have recently been shown to have anti-MAP activity in vitro. (medicpdf.com)
- Over a decade since joining the University of Sydney, he has developed a leading research program on aerosol drug delivery, ranging from in vitro , ranging from powder production by novel processes, particle engineering and aerosol formulation, to scintigraphic imaging of lung deposition and clinical outcome. (edu.au)
- These findings confirm and extend previous findings that certain drug combinations have superior activity against B. burgdorferi persisters in vitro , even when pre-treated with amoxicillin. (canlyme.com)
- In 2014, Professor Katanaev's team (at UNIL back then) had shown in vitro the inhibitory effect of clofazimine on the Wnt signalling pathway in triple negative breast cancer. (scienmag.com)
- BCCM/ITM has incorporated the first publically available in vitro selected reference strains for BDQ and Cfz, and is in the process of expanding these numbers, as well as adding reference strains for other recently discovered drugs. (belspo.be)
- The medical records and imaging examinations of those patients with NTM infection who were known to be immunocompetent and who had undergone either CT or MR imaging were reviewed. (ajnr.org)
- Lacking sensation of pain, patients have little regard for the dangers of infection, which results in raw, oozing sores and deformed hands and feet. (timesuniononline.com)
- however, MAC colonization of these sites indicates that patients are at increased risk for developing disseminated MAC infection. (ucsf.edu)
- 11 ) Whether MAC can be eradicated once disseminated infection has been established is uncertain, but there have been recent studies that suggest secondary prophylaxis may be discontinued in patients who have had sustained immunologic recovery. (ucsf.edu)
- The source of MAC infection in HIV-infected patients remains uncertain. (ucsf.edu)
- In 1994, the U.S. Public Health Service (USPHS) and the Infectious Diseases Society of America (IDSA) recognized that, although strategies were available to reduce the frequency of opportunistic infections in patients who have human immunodeficiency virus (HIV) infection, information regarding prevention of both exposure and disease often was published in journals not regularly reviewed by health-care providers. (cdc.gov)
- However, these decreases have not been observed among HIV-infected injecting-drug users, suggesting that more emphasis should be placed on providing currently recommended chemoprophylactic agents to all persons who have HIV infection and who meet appropriate criteria for prophylaxis for opportunistic infections. (cdc.gov)
- 3 Disseminated MAI infection not associated with AIDS has been reported in 13 patients by Horsburgh 4 and in 32 patients by Stone. (aappublications.org)
- T. cruzi infection results in a latent infection with approximately a third of latently infected patients developing chronic Chagas cardiomyopathy (CCM). (medworm.com)
- We know that the combination of available drugs might not work-well for these deadly bacilli, but for the time -being we can strictly follow international policy on TB infection control in health-care facilities, congregate settings and households. (atlasofscience.org)
- This is a good thing because you would like to treat the infection with the lowest concentration of drugs possible. (asu.edu)
- Cryptosporidiosis, a diarrheal disease usually caused by Cryptosporidium parvum or Cryptosporidium hominis in humans, can result in fulminant diarrhea and death in AIDS patients and chronic infection and stunting in children. (pubmedcentralcanada.ca)
- Conversion to culture-negative sputum samples was achieved in 10 (24%) patients after CFZ-containing antibiotic treatment, and during treatment, there were significant decreases in the positivity of semiquantitative sputum cultures for acid-fast bacilli in both the initial (P = 0.018) and salvage (P = 0.001) treatment groups. (yonsei.ac.kr)
- By studying the properties of clofazimine, a 70-year-old antibiotic, scientists from the Universities of Geneva (UNIGE) and Lausanne (UNIL), in Switzerland, demonstrate its effectiveness in stopping the progression of the disease in in vivo tests. (scienmag.com)
- The drug may also be used in antibiotic combination with other medicines to eliminate. (carbuyinghowto.com)
- Within the last decade, several components of this central pathway have been identified as antibacterial targets, and small-molecule inhibitors of oxidative phosphorylation are active against drug-sensitive and drug-resistant TB. (asm.org)
- Several new antibacterial candidates shared the stage with promising agents that augment antimicrobial drugs, combination agents that work better than their separate components, and antifungal candidate agents-presented this year during the poster summary session "Early New Antimicrobial Agents," convened at the 2016 ASM Microbe Meeting, held in Boston, Mass., in June. (asmscience.org)
- Clofazimine, an antibacterial agent used to fight leprosy, has been on the market for a long time and is, in fact, in the public domain. (scienmag.com)
- Therefore, strategies to reduce the dose of bedaquiline while retaining its antibacterial activity would provide significant benefits to patients. (eurekalert.org)
- [ 37 ] and their use in combination with antibacterial drugs such as metronidazole has been an effective treatment in several instances. (medscape.com)
- The patient is asked to return at once if there are any signs of relapse or reaction (WHO - 1988 recommendations). (yourarticlelibrary.com)
- Of 12 030 patients from 25 countries in 50 studies, 7346 (61%) had treatment success, 1017 (8%) had failure or relapse, and 1729 (14%) died. (drzarirudwadia.com)
- These CV structural analogues could be a starting point to design therapeutic alternatives to treat Chagas disease by finding new indications for old drugs. (medworm.com)
- The discovery of new indications for existing medications, known as drug repurposing (or repositioning), provides an attractive alternative ( 10 ) to de novo drug development. (pubmedcentralcanada.ca)
- Determination of drug susceptibility may be helpful for certain organism/drug combinations but can be done only in highly specialized laboratories. (msdmanuals.com)
- However, due to limitation of drug susceptibility test (DST) for second-line drugs, the practical definition for TDR is not available ( 5 ). (pedinfect.com)
- Secondly, surveillance data were available from a very small number of patients in only a few countries, and only those with extensive drug susceptibility testing (DST) capacity. (atlasofscience.org)
- All patients should receive a Group 2 injectable agent if susceptibility is documented or the drug is considered likely to be effective. (msf.org)
- Along with the introduction of these new drugs, comes the need for standardized drug-susceptibility testing methods and the use of appropriate reference strains. (belspo.be)
- 1 second-line injectable drugs) ( 1 , 2 ). (cdc.gov)
- For better estimation of XDR-TB prevalence, routine DST for second-line drugs (quinolones and injectable agents) must be performed. (pedinfect.com)
- If well tolerated it is used for the entire treatment, although patients doing well and with minimal lung disease can have it stopped with the injectable agent and continue with at least three likely effective drugs. (msf.org)
- Lamprene (clofazimine) is indicated in the treatment of lepromatous leprosy , including dapsone-resistant lepromatous leprosy and lepromatous leprosy complicated by erythema nodosum leprosum. (rxlist.com)
- Resistant patients, who are unresponsive to drugs, suffer from increasingly ill health and may even die. (fapesp.br)
- A possible explanation for the growing number of new cases is that the bacterium may be becoming resistant to drugs. (fapesp.br)
- To achieve global control of this epidemic, there is an urgent need for new anti-TB drugs that can target MDR and XDR strains and shorten treatment duration for both drug-sensitive and drug-resistant TB ( 4 - 6 ). (asm.org)
- Some forms of TB are also resistant to second-line medications, and are called extensively drug-resistant TB (XDR-TB). (wikipedia.org)
- Other mutations make the bacterium resistant to other drugs. (wikipedia.org)
- A complex of rapidly growing and frequently drug-resistant mycobacterial species. (unboundmedicine.com)
- Nevertheless, the most threatening issue is emerging of totally drug-resistant TB (TDR), which is defined as TB causes by a resistant strain to all available first- and second-line drugs ( 4 ). (pedinfect.com)
- Since the XDR-TB is resistant to first- and second-line drugs, the treatment options are seriously limited. (pedinfect.com)
- Even worse, there is a high fatality rate among those with drug-resistant TB. (ucla.edu)
- Cross section of cell wall of totally -drug resistant TB bacilli (TDR-TB cell) recorded by atomic force microcopy (AFM). (atlasofscience.org)
- Scientists investigated how the TB cells had become resistant to BDQ and if it should be prescribed with other drugs to help effectively treat TB. (asu.edu)
- Two years ago, bedaquiline became the first drug in the last four decades to be approved by the U.S. Food and Drug Administration for the treatment of multidrug-resistant TB. (eurekalert.org)
- Thus bactericidal drugs are used in combination and this reduces the chances of evolution of mutants that are resistant to any of the drugs in combination. (yourarticlelibrary.com)
- After their last intake of TMC207, all patients will continue to take their BR under the supervision of their treating physician or local health center/hospital in accordance with NTP guidelines and local multi-drug resistant (MDR) TB treatment practice (i.e., treatment may be extended for reasons of complicated lung disease, etc. (reaganudall.org)
- The regulatory approval of the ATP synthase inhibitor bedaquiline and the discovery of Q203, a candidate drug targeting the cytochrome bc 1 complex, have highlighted the central importance of this new target pathway. (asm.org)
- Clofazimine is also a FIASMA (functional inhibitor of acid sphingomyelinase). (wikipedia.org)
- Alexey Koval, a researcher at the CRTOH of the UNIGE at the Faculty of Biology and Medicine of the UNIL and co-first author of this study, analyses these results: "Clofazimine acts as an inhibitor of the Wnt signaling pathway: the sick cell can no longer divide, but does not die. (scienmag.com)
- Household contacts of most cases and the medical personnel caring for Hansen's disease patients are not at particular risk. (encyclopedia.com)
- Researchers had unsuccessfully attempted to induce the disease in animals by injecting them with cells from Hansen's patients. (faqs.org)
- Hansen's career at the Lungegard Hospital came to an end in 1880 when he inoculated one of his patients with live leprosy bacilli without obtaining her permission. (faqs.org)
- Clofazimine is taken to treat leprosy (Hansen's disease). (medypharma.com)
- Thus, it is important to understand how synergistic or antagonistic drug interactions affect the efficacy of combination therapies. (sciencemag.org)
- Therefore, it is important to understand how combining drugs changes treatment efficacy. (sciencemag.org)
- Treatments that include a synergistic combination achieve the same efficacy with a relatively lower total dose, potentially improving efficacy, alleviating side effects, and shortening treatment ( 1 , 2 ). (sciencemag.org)
- Term efficacy of varicocelectomy on serum phosphatases in metastatic patients, aging is the long. (bvbdallas.org)
- Where there is no difference in terms of efficacy and safety data, the listed medicine should be the one that is generally available at the lowest price, based on international drug price information sources. (who.int)
- Compared to other drugs in this group bedaquiline is the only one with proven efficacy against TB. (msf.org)
- However, the independent contribution of the investigational new drug pretomanid to the efficacy of BPaMZ has not been examined, and its contribution to BPaL has been examined only over the first 2 months of treatment. (asm.org)
- A combination of great efficacy! (scienmag.com)
- Evidence for efficacy is insufficient to support a recommendation for or against use, or evidence for efficacy might not outweigh adverse consequences (e.g., drug toxicity, drug interactions) or cost of the chemoprophylaxis or alternative approaches. (aafp.org)
- To overcome these constraints, new TB drugs were deemed essential and have been developed, yet their safety and efficacy are being assessed in Phase II and III clinical trials for patients with MDR-TB. (belspo.be)
- Nitazoxanide, the current standard of care, has limited efficacy in children and is no more effective than placebo in patients with advanced AIDS. (pubmedcentralcanada.ca)
- Nitazoxanide (NTZ), the current standard of care, exhibits only moderate clinical efficacy in immunocompetent adults and children, and it is not effective in patients with advanced AIDS ( 7 ). (pubmedcentralcanada.ca)
- Non-allergic drug eruptions may be due to idiosyncratic drug reactions, enzyme deficiencies, irritant dermatitis, and cumulative toxicity. (news-medical.net)
- The rash may be induced by toxicity, in which case it occurs in all people who take the drug at levels exceeding a critical dose, and may be severe enough to appear as sunburn. (news-medical.net)
- Clofazimine, initially known as B663, was first synthesised in 1954 by a team of scientists at Trinity College, Dublin: Frank Winder, J.G. Belton, Stanley McElhinney, M.L. Conalty, Seán O'Sullivan, and Dermot Twomey, led by Vincent Barry. (wikipedia.org)
- 1) were shown for various FRDC of the three standard chemotherapeutics tested (etoposide, paclitaxel and vinblastine) in combination with either B663 or B4125 against MDR neoplastic cell cultures. (up.ac.za)
- Importantly, all components (amphiphiles and drugs) used in assembly of Riminocelles are already individually approved for medicinal use - this promotes accelerated development towards advanced clinical trials and successful registration. (up.ac.za)
- These researchers can access and analyze data in aggregate, or filter and view individual patient-level data from seventeen clinical trials, including REMoxTB, RIFAQUIN and OFLUTUB. (c-path.org)
- Approved researchers can access patient-level data from seventeen clinical trials, including REMoxTB, RIFAQUIN and OFLOTUB. (c-path.org)
- Objetivo: Caracterizar aspectos clínicos de la lepra en el municipio Guantánamo en el periodo de 2015-2019. (bvsalud.org)
- the higher dosage of the combination displayed bactericidal activity which was significantly inferior to that of a single dose of RMP, whereas the lower dosage did not exhibit a bactericidal effect. (asm.org)
- The OFLO-MINO combination exhibited definite bactericidal activity in 7 of 10 patients but was less bactericidal than the RMP-OFLO-MINO combination. (asm.org)
- The strategic intent of this project was to attain improved therapeutic benefit for patients through gains in both pharmaco dynamic and pharmacokinetic specificity for cancer cells over what is currently available. (up.ac.za)
- This new drug was registered by the US FDA in December 2012 2 for MDR-TB patients with no other therapeutic options. (msf.org)
- We developed an efficient experimental sampling and scoring method [diagonal measurement of n -way drug interactions (DiaMOND)] to measure drug interactions for combinations of any number of drugs. (sciencemag.org)
- DiaMOND provides an efficient alternative to checkerboard assays, which are commonly used to measure drug interactions. (sciencemag.org)
- We established a geometric framework to factorize high-order drug interactions into lower-order components, thereby establishing a road map of how to use lower-order measurements to predict high-order interactions. (sciencemag.org)
- Our framework is a generalized Loewe additivity model for high-order drug interactions. (sciencemag.org)
- Efficient measurement and factorization of high-order drug interactions by DiaMOND are broadly applicable to other cell types and disease models. (sciencemag.org)
- In synergistic or antagonistic drug interactions, drugs in combination may be, respectively, more or less effective than what is expected from the individual drugs. (sciencemag.org)
- Tactically, this was driven through the use of synergistic Fixed-Ratio Drug Combinations (FRDC) encapsulated within tumour-targeting Nanoparticulate Drug Delivery Systems (NDDS). (up.ac.za)
- This formulation is therefore thought capable of CT imaging of tumour tissue and drug targeting after either intravenous or loco-regional injection. (up.ac.za)
- They now confirm this effect in vivo, in animal models of the disease: "With clofazimine, tumour growth is significantly reduced", says Vladimir Katanaev. (scienmag.com)
- Drugs were less effective in C3HeB/FeJ mice forming caseous granulomas. (nih.gov)
- MDT (Multi-Drug Thedrapy) remains highly effective and people are no longer infectious after the first monthly dose. (dmacdigest.com)
- The modes of action for most of the effective classes of drugs against M. leprae occur at the level of nucleic acid and protein synthesis. (internationaltextbookofleprosy.org)
- To identify more effective drugs with activity against the round body form of B. burgdorferi , we established a round body persister model induced by exposure to amoxicillin (50 μg/ml) and then screened the Food and Drug Administration drug library consisting of 1581 drug compounds and also 22 drug combinations using the SYBR Green I/propidium iodide viability assay. (canlyme.com)
- In addition, clofazimine is even more effective when administered in combination with doxorubicin, a conventional chemotherapeutic drug. (scienmag.com)
- How our current drugs work and the need to develop new and more effective drugs. (slideserve.com)
- The optimal number of effective drugs seemed to be five in the initial phase, and four in the continuation phase. (drzarirudwadia.com)